Jacob McPhail, PhD

Title(s)Professional Researcher, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #316
San Francisco CA 94158
PronounsHe/Him/His
ORCID ORCID Icon0000-0003-1490-808X Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms. Alzheimers Dement. 2024 Dec 23. Falkon KF, Danford L, Gutierrez Kuri E, Esquinca-Moreno P, Peña Señeriz YL, Smith S, Wickline JL, Louwrier A, McPhail JA, Sayre NL, Hopp SC. PMID: 39713861.
      View in: PubMed   Mentions:    Fields:    
    2. Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates. Sci Adv. 2023 11 17; 9(46):eadi7359. Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. PMID: 37967183; PMCID: PMC10651132.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Molecular mechanisms of PI4K regulation and their involvement in viral replication. Traffic. 2023 03; 24(3):131-145. McPhail JA, Burke JE. PMID: 35579216.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    4. Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. J Am Chem Soc. 2022 04 13; 144(14):6326-6342. Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP. PMID: 35353516; PMCID: PMC9011356.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    5. Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors. ACS Infect Dis. 2020 11 13; 6(11):3048-3063. Fienberg S, Eyermann CJ, Arendse LB, Basarab GS, McPhail JA, Burke JE, Chibale K. PMID: 32966036.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    6. Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections. Adv Exp Med Biol. 2020; 1274:203-222. McPhail JA, Burke JE. PMID: 32894512.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    7. Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication. EMBO Rep. 2020 02 05; 21(2):e48441. McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE. PMID: 31829496; PMCID: PMC7001497.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    8. (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J Med Chem. 2019 07 11; 62(13):6241-6261. Rageot D, Bohnacker T, Keles E, McPhail JA, Hoffmann RM, Melone A, Borsari C, Sriramaratnam R, Sele AM, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Burke JE, Wymann MP. PMID: 31244112.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria". Antimicrob Agents Chemother. 2018 11; 62(11). Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. PMID: 30355750; PMCID: PMC6201132.
      View in: PubMed   Mentions:    Fields:    
    10. Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5. Nat Commun. 2018 09 14; 9(1):3772. Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. PMID: 30217979; PMCID: PMC6138693.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    11. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother. 2018 09; 62(9). Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. PMID: 29941635; PMCID: PMC6125526.
      View in: PubMed   Mentions: 27     Fields:    
    12. The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3. Structure. 2017 01 03; 25(1):121-131. McPhail JA, Ottosen EH, Jenkins ML, Burke JE. PMID: 27989622.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    13. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20; 538(7625):344-349. Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. PMID: 27602946; PMCID: PMC5515376.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    14. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10; 59(5):1830-9. Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE. PMID: 26885694; PMCID: PMC5289284.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease. Biochem Soc Trans. 2016 Feb; 44(1):260-6. Dornan GL, McPhail JA, Burke JE. PMID: 26862213.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr; 25(4):826-39. Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. PMID: 26756197; PMCID: PMC4832280.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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