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Philip Rosenthal, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-8845
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1988 Medicine
    University of California, San Francisco Clinical Fellowship Infectious Diseases
    University of MichiganResidency School of Medicine

    Collapse Overview 
    Collapse Overview
    We have three main areas of interest, all involving malaria, one of the most important infections of humans. First, we study the basic biology of malaria parasites, including the biochemical properties and biological roles of parasite proteases and mechanisms of action of novel antimalarial agents. Second, in collaboration with industry and academic groups, we are pursuing drug discovery, evaluating protease inhibitors, oxaboroles, and other compounds as potential antimalarial drugs. Third, we study malaria in Africa, with translational and laboratory studies at UCSF and in Uganda and Burkina Faso evaluating antimalarial drug efficacy and resistance, the molecular epidemiology of malaria, the roles of host and parasite genetic polymorphisms in treatment outcomes, antimalarial pharmacokinetics and pharmacodynamics, and related areas. Finally, a new area of interest is using genetic tools to characterize causes of febrile illness in African children. In other activities, Dr. Rosenthal is Editor-in-Chief of the American Journal of Tropical Medicine and Hygiene; Chair, Scientific Advisory Committee, WorldWide Antimalarial Resistance Network; Member, Scientific Board, Infectious Diseases Data Observatory; and a member of the World Health Organization Technical Expert Group on Malaria Chemotherapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda
    NIH/NIAID U01AI141308Apr 15, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline
    NIH/NIAID R01AI139179Jun 22, 2018 - May 31, 2023
    Role: Principal Investigator
    Pharmacological insights into antimalarial exposure, clinical outcomes, and drug resistance in Africa
    NIH/NIAID R01AI117001Feb 10, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Discovery of Oxaboroles as New Antimalarial Agents
    NIH/NIAID R01AI095324Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Discovery of Oxaboroles as New Antimalarial Agents
    NIH/NIAID R56AI095324Sep 30, 2011 - Mar 31, 2012
    Role: Principal Investigator
    Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    NIH/NIAID R56AI075045Aug 1, 2008 - Jul 31, 2009
    Role: Principal Investigator
    Resistance of Malaria Parasites to Artemisinin-Based Therapies
    NIH/NIAID R01AI075045Jul 1, 2007 - Nov 30, 2019
    Role: Principal Investigator
    Training In Malaria Research in Uganda
    NIH/FIC D43TW007375Sep 16, 2005 - May 31, 2015
    Role: Principal Investigator
    Clinical &Molecular Studies of Drug Resistant Malaria
    NIH/NIAID U01AI052142Aug 15, 2003 - Feb 29, 2008
    Role: Principal Investigator
    TRAINING IN MALARIA RESEARCH IN UGANDA
    NIH/FIC D43TW001506Sep 29, 2000 - Feb 28, 2009
    Role: Principal Investigator
    MOLECULAR APPROACHES TO DRUG RESISTANT MALARIA
    NIH/NIAID R03AI043301Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH/NIAID P01AI035707May 1, 1995 - May 31, 2010
    Role: Co-Investigator
    PROTEINASE-LIKE MALARIAL ANTIGENS
    NIH/NIAID U01AI036463Sep 15, 1994 - Aug 31, 1998
    Role: Principal Investigator
    Falcipain Cysteine Proteases of Malaria Parasites
    NIH/NIAID R56AI035800Jul 1, 1994 - May 31, 2008
    Role: Principal Investigator
    EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    NIH/NIAID R01AI035800Jul 1, 1994 - May 31, 2005
    Role: Principal Investigator
    MALARIAL HEMOGLOBINASE
    NIH/NIAID R29AI035800Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    MOLECULAR APPROACHES TO A MALARIAL CYSTEINE
    NIH/NIAID K11AI000870Mar 1, 1988 - Feb 28, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatic Histology in Treatment-naïve Children With Chronic Hepatitis B Infection Living in the United States and Canada. J Pediatr Gastroenterol Nutr. 2020 Jul; 71(1):99-105. Rodriguez-Baez N, Murray KF, Kleiner DE, Ling SC, Rosenthal P, Carlin K, Cooper K, Schwarz KB, Schwarzenberg SJ, Teckman JH, Ghany MG, Alawad AS. PMID: 32265408.
      View in: PubMed   Mentions:    Fields:    
    2. Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cell Mol Immunol. 2020 Jun 15. Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F. PMID: 32541835.
      View in: PubMed   Mentions:    Fields:    
    3. Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean. Am J Trop Med Hyg. 2020 Jun 09. Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG, Rosenthal PJ, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG. PMID: 32524963.
      View in: PubMed   Mentions:    Fields:    
    4. Amalgamating Isatin/Indole/Nitro-imidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial and cytotoxic evaluation. Chem Biol Drug Des. 2020 Jun 08. Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. PMID: 32515142.
      View in: PubMed   Mentions:    Fields:    
    5. Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations. PLoS One. 2020; 15(5):e0233893. Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. PMID: 32470030.
      View in: PubMed   Mentions:    Fields:    
    6. Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3-11 Years with Hepatitis C Genotype 1a. Adv Ther. 2020 May 25. Rosenthal P, Narkewicz MR, Yao BB, Jolley CD, Lobritto SJ, Wen J, Molleston JP, Hsu EK, Jonas MM, Zha J, Liu L, Leung DH. PMID: 32451952.
      View in: PubMed   Mentions:    Fields:    
    7. The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. Am J Trop Med Hyg. 2020 May 18. Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G. PMID: 32431280.
      View in: PubMed   Mentions:    Fields:    
    8. Alanine Aminotransferase and Gamma Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis. Hepatology. 2020 May 16. Newton KP, Lavine JE, Wilson L, Behling C, Vos MB, Molleston JP, Rosenthal P, Miloh T, Fishbein MH, Jain AK, Murray KF, Schwimmer JB. PMID: 32416645.
      View in: PubMed   Mentions:    Fields:    
    9. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. J Med Chem. 2020 May 11. Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper R, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. PMID: 32390431.
      View in: PubMed   Mentions:    Fields:    
    10. Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS Infect Dis. 2020 May 05. Blank B, Gonciarz R, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR. PMID: 32369341.
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    11. COVID-19: Shining the Light on Africa. Am J Trop Med Hyg. 2020 May 05. Rosenthal PJ, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG. PMID: 32372749.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    12. The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). Am J Trop Med Hyg. 2020 05; 102(5):915-916. Rosenthal PJ. PMID: 32238224.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    13. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun. 2020 Apr 30; 11(1):2107. Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. PMID: 32355199.
      View in: PubMed   Mentions: 1     Fields:    
    14. Are three drugs for malaria better than two? Lancet. 2020 04 25; 395(10233):1316-1317. Rosenthal PJ. PMID: 32171077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020 01 28; 11(1). Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ. PMID: 31992618.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J. 2020 Jan 15; 19(1):21. Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I. PMID: 31941490.
      View in: PubMed   Mentions:    Fields:    
    17. Falcipain cysteine proteases of malaria parasites: An update. Biochim Biophys Acta Proteins Proteom. 2020 03; 1868(3):140362. Rosenthal PJ. PMID: 31927030.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights. ACS Med Chem Lett. 2020 Feb 13; 11(2):154-161. Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V. PMID: 32071682.
      View in: PubMed   Mentions:
    19. Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates. Molecules. 2019 Dec 12; 24(24). Aguiar L, Biosca A, Lantero E, Gut J, Vale N, Rosenthal PJ, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P. PMID: 31842498.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. Future Med Chem. 2020 Feb; 12(3):193-205. Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. PMID: 31802710.
      View in: PubMed   Mentions:    Fields:    
    21. Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. Malar J. 2019 Dec 03; 18(1):389. Oldenburg CE, Amza A, Cooley G, Kadri B, Nassirou B, Arnold BF, Rosenthal PJ, O'Brien KS, West SK, Bailey RL, Porco TC, Keenan JD, Lietman TM, Martin DL. PMID: 31796025.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    22. Malaria parasites fine-tune mutations to resist drugs. Nature. 2019 12; 576(7786):217-219. Tilley L, Rosenthal PJ. PMID: 31822828.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. Am J Trop Med Hyg. 2019 12; 101(6):1424-1433. Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS. PMID: 31595873.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-ß-carboline-4-aminoquinoline conjugates. Bioorg Med Chem Lett. 2020 01 15; 30(2):126810. Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V. PMID: 31740250.
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    25. Be Careful What You Eat! Am J Trop Med Hyg. 2019 11; 101(5):955-956. Rosenthal PJ. PMID: 31549613.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    26. [(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity. EXCLI J. 2019; 18:962-987. de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J, Rosenthal PJ, Gut J. PMID: 31762723.
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    27. The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda. Antimicrob Agents Chemother. 2019 10; 63(10). Conrad MD, Nsobya SL, Rosenthal PJ. PMID: 31358588.
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    28. Artemisinin Resistance in Eastern India. Clin Infect Dis. 2019 09 13; 69(7):1153-1155. Rosenthal PJ. PMID: 30541018.
      View in: PubMed   Mentions:    Fields:    
    29. Antimalarial drug resistance in Africa: the calm before the storm? Lancet Infect Dis. 2019 10; 19(10):e338-e351. Conrad MD, Rosenthal PJ. PMID: 31375467.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    30. Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention. Clin Pharmacol Ther. 2019 12; 106(6):1310-1318. Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT. PMID: 31173649.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. A shorter course for anti-relapse therapy against vivax malaria. Lancet. 2019 09 14; 394(10202):898-900. Rosenthal PJ. PMID: 31327565.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand? Clin Infect Dis. 2019 07 02; 69(2):287-289. Guler JL, Rosenthal PJ. PMID: 30304408.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    33. Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. Nat Commun. 2019 06 27; 10(1):2816. Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. PMID: 31249291.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    34. Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial. PLoS Med. 2019 06; 16(6):e1002835. Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD. PMID: 31237871.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    35. Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. PLoS One. 2019; 14(6):e0218318. Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL. PMID: 31220115.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. J Med Chem. 2019 07 11; 62(13):6137-6145. Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. PMID: 31177777.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    37. Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda. PLoS One. 2019; 14(6):e0217262. Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A. PMID: 31166968.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    38. Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States. Am J Trop Med Hyg. 2019 06; 100(6):1295-1296. Rosenthal PJ, Tan KR. PMID: 30927931.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. 2019 06 13; 62(11):5562-5578. Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ. PMID: 31062592.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation. Bioorg Chem. 2019 07; 88:102912. Rani A, Legac J, Rosenthal PJ, Kumar V. PMID: 30991190.
      View in: PubMed   Mentions: 1     Fields:    
    41. Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda. J Infect Dis. 2019 03 15; 219(7):1104-1111. Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B. PMID: 30383230.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    42. Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children. J Infect Dis. 2019 03 15; 219(7):1112-1120. Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ. PMID: 30418593.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    43. Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda. Antimicrob Agents Chemother. 2019 03; 63(3). Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ. PMID: 30559133.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. Malaria: How Are We Doing and How Can We Do Better? Am J Trop Med Hyg. 2019 02; 100(2):239-241. Rosenthal PJ, John CC, Rabinovich NR. PMID: 30628572.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    45. Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. Nat Commun. 2019 01 29; 10(1):480. Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J. PMID: 30696903.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. Antimicrob Agents Chemother. 2019 02; 63(2). Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. PMID: 30530597.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda. Clin Infect Dis. 2019 01 07; 68(2):313-320. Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG. PMID: 29868722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Volume 100 of the American Journal of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2019 01; 100(1):3-4. Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW. PMID: 30652665.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    49. Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria. Malar J. 2018 Dec 18; 17(1):476. Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G. PMID: 30563514.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Artemisinin Resistance Outside of Southeast Asia. Am J Trop Med Hyg. 2018 12; 99(6):1357-1359. Rosenthal PJ. PMID: 30426924.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    51. Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS One. 2018; 13(9):e0204347. Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. PMID: 30235327.
      View in: PubMed   Mentions: 2     Fields:    
    52. Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One. 2018; 13(9):e0203229. Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ. PMID: 30222732.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis. 2018 09 14; 67(7):1079-1088. Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT. PMID: 29547881.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. PMID: 30138453.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    55. Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis. 2018 07 02; 218(3):434-442. Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L. PMID: 29659945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    56. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6863-E6870. Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G. PMID: 29967165.
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    57. Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis. 2018 03 05; 217(6):964-972. Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM. PMID: 29272443.
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    58. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem. 2018 Apr 10; 149:69-78. Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. PMID: 29499488.
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    59. Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J. 2018 Feb 05; 17(1):67. Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. PMID: 29402282.
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    60. "The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health. Am J Trop Med Hyg. 2017 12; 97(6):1955-1957. Dunavan CP, Rosenthal PJ. PMID: 29187275.
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    61. Changing Antimalarial Drug Sensitivities in Uganda. Antimicrob Agents Chemother. 2017 12; 61(12). Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL, Rosenthal PJ, Cooper RA. PMID: 28923866.
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    62. Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2018 Jan 01; 143:150-156. Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V. PMID: 29174811.
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    63. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. J Infect Dis. 2017 11 15; 216(8):1008-1017. Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 28968782.
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    64. Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg. 2017 Nov; 97(5):1513-1523. Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C. PMID: 29016322.
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    65. Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda. Am J Trop Med Hyg. 2017 Nov; 97(5):1576-1580. Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ. PMID: 29016309.
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    66. Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Am J Trop Med Hyg. 2017 12; 97(6):1777-1781. Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. PMID: 29016335.
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    67. Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol. 2017 11; 55:281-287. Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. PMID: 28939159.
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    68. Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center. Am J Trop Med Hyg. 2017 09; 97(3):629-630. Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF. PMID: 28990909.
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    69. Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg. 2017 Sep; 97(3):753-757. Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ. PMID: 28990911.
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    70. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem. 2017 08 24; 60(16):6911-6923. Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. PMID: 28763614.
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    71. The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017 Aug 01; 65(3):486-494. Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal PJ. PMID: 28402391.
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    72. 4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation. Eur J Med Chem. 2017 Sep 29; 138:993-1001. Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V. PMID: 28756265.
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    73. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. Am J Trop Med Hyg. 2017 Sep; 97(3):696-701. O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM. PMID: 28722569.
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    74. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407. Blank BR, Gut J, Rosenthal PJ, Renslo AR. PMID: 28692297.
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    75. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. J Med Chem. 2017 07 13; 60(13):5889-5908. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J. PMID: 28635296.
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    76. Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Chem Biol Drug Des. 2017 Oct; 90(4):590-595. Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V. PMID: 28332319.
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    77. Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J. 2017 03 21; 16(1):125. Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ. PMID: 28327148.
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    78. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017 03 06; 8:14574. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. PMID: 28262680.
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    79. Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Mol Med. 2017 03; 9(3):385-394. Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. PMID: 28148555.
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    80. Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis. 2017 02 15; 215(4):631-635. Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 28039354.
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    81. Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J. 2017 02 10; 16(1):67. Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK. PMID: 28183299.
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    82. Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg. 2017 Jan 11; 96(1):5-6. Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. PMID: 28077738.
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    83. Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. Antimicrob Agents Chemother. 2017 01; 61(1). Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ. PMID: 27821443.
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    84. Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study. PLoS Med. 2016 Nov; 13(11):e1002167. Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Kamya MR, Dorsey G. PMID: 27824885.
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    85. The (International) American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2016 Nov 02; 95(5):980-982. Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. PMID: 27807294.
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    86. Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda. Open Forum Infect Dis. 2017; 4(1):ofw229. Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ. PMID: 28480232.
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    89. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 10; 60(10):5817-27. Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. PMID: 27431220.
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    90. 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2017 Jan 05; 125:269-277. Singh A, Gut J, Rosenthal PJ, Kumar V. PMID: 27688182.
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    91. Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. Malar J. 2016 09 15; 15:470. Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B. PMID: 27628178.
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    92. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016 10 06; 11(19):2194-2204. Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. PMID: 27538856.
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    93. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 08; 60(8):4886-95. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. PMID: 27270277.
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    94. Azithromycin for Malaria? Am J Trop Med Hyg. 2016 07 06; 95(1):2-4. Rosenthal PJ. PMID: 27215296.
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    95. Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorg Med Chem. 2016 Apr 15; 24(8):1786-92. Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM. PMID: 26968650.
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    96. Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Malar J. 2015 Dec 30; 14:528. Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG. PMID: 26714465.
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    97. Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial. J Infect Dis. 2016 Apr 01; 213(7):1134-42. Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. PMID: 26597254.
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    98. Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites. ChemMedChem. 2015 Dec; 10(12):2080-9. Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MM. PMID: 26525306.
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    99. Artefenomel: a promising new antimalarial drug. Lancet Infect Dis. 2016 Jan; 16(1):6-8. Rosenthal PJ. PMID: 26448142.
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    100. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. PMID: 26617969.
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    102. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):57-68. Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. PMID: 26259943.
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    103. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4438-47. Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B. PMID: 26216993.
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    104. Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. J Med Chem. 2015 Jul 09; 58(13):5344-54. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y. PMID: 26067904.
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    105. Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test. Am J Trop Med Hyg. 2015 Aug; 93(2):276-280. Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR. PMID: 26055736.
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    106. Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother. 2015 Aug; 59(8):5061-4. Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. PMID: 26033725.
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    107. Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2015 Aug; 59(8):4387-96. Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J, Rosenthal PJ, Sutherland C, Nosten F, Ouedraogo JB. PMID: 25918149.
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    109. Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates. Eur J Med Chem. 2015 May 05; 95:230-9. Raj R, Saini A, Gut J, Rosenthal PJ, Kumar V. PMID: 25817773.
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    110. Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids. ChemMedChem. 2015 May; 10(5):883-90. Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R. PMID: 25784585.
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    111. Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme. Arch Biochem Biophys. 2015 May 01; 573:92-9. Marques AF, Gomes PS, Oliveira PL, Rosenthal PJ, Pascutti PG, Lima LM. PMID: 25791019.
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    112. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg. 2015 May; 92(5):903-12. Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G. PMID: 25778501.
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    113. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015; 59(6):3018-30. Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, Greenhouse B, Nsobya SL, Rosenthal PJ. PMID: 25753626.
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    114. The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots. Am J Trop Med Hyg. 2015 May; 92(5):922-5. Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B. PMID: 25758652.
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    115. N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity. Bioorg Med Chem. 2015 Apr 01; 23(7):1530-9. Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. PMID: 25725608.
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    116. Perspectives on Ebola. Am J Trop Med Hyg. 2015 Feb; 92(2):219-220. Rosenthal PJ, Bausch DG. PMID: 25582689.
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    117. Reply to Goyal et al. J Infect Dis. 2015 May 15; 211(10):1687. Hsiang MS, Greenhouse B, Rosenthal PJ. PMID: 25512627.
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    118. Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem. 2014 Dec 26; 57(24):10557-63. Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ. PMID: 25412465.
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    119. Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. Eur J Med Chem. 2015 Jan 27; 90:507-18. Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. PMID: 25486422.
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    120. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. PMID: 25493596.
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    121. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. PMID: 25314098.
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    122. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis. 2015 Mar 01; 211(5):680-8. Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. PMID: 25180240.
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    123. Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. PLoS One. 2014; 9(8):e105690. Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. PMID: 25144768.
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    124. Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine. PLoS One. 2014; 9(8):e103200. Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. PMID: 25133389.
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    125. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med. 2014 Aug; 11(8):e1001689. Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. PMID: 25093754.
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    126. ß-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation. Eur J Med Chem. 2014 Sep 12; 84:566-73. Gut J, Rosenthal PJ, Kumar V. PMID: 25062007.
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    127. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am J Trop Med Hyg. 2014 Oct; 91(4):833-843. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, Sibley CH. PMID: 25048375.
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    128. Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity. Eur J Med Chem. 2014 Sep 12; 84:425-32. Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. PMID: 25038484.
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    129. Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum. J Enzyme Inhib Med Chem. 2015 Apr; 30(2):299-307. Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H. PMID: 24964346.
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    130. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. J Med Chem. 2014 Jun 12; 57(11):4916-23. Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F. PMID: 24824551.
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    131. Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria. Clin Infect Dis. 2014 Aug 15; 59(4):509-16. Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G. PMID: 24825870.
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    132. Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg. 2014 Jul; 91(1):54-61. Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ. PMID: 24799371.
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    133. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014 Oct 15; 210(8):1167-9. Hsiang MS, Greenhouse B, Rosenthal PJ. PMID: 24795471.
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    134. Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity. Eur J Med Chem. 2014 Jun 10; 80:523-34. Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R. PMID: 24813880.
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    135. Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis. 2014 Aug 01; 59(3):446-53. Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G. PMID: 24759826.
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    136. Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):535-41. Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J. PMID: 24326597.
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    137. Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem. 2014 Apr 24; 57(8):3295-313. Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. PMID: 24673163.
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    138. Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2014 Jul; 58(7):3660-5. Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ. PMID: 24733476.
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    139. Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. PLoS One. 2014; 9(4):e93008. Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R, Rosenthal PJ, Pandey KC. PMID: 24699522.
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    140. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections. Malar J. 2014 Mar 17; 13:102. Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC. PMID: 24636676.
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    141. 7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. Chem Biol Drug Des. 2014 May; 83(5):622-9. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V. PMID: 24341638.
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    142. Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J. 2014 Mar 14; 13:95. Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL, Rosenthal PJ. PMID: 24629020.
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    143. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis. 2014 May; 58(10):1404-12. Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR. PMID: 24621953.
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    144. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Am J Trop Med Hyg. 2014 May; 90(5):846-51. Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM. PMID: 24615132.
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    145. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis. 2014 Aug 01; 210(3):344-53. Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ. PMID: 24610872.
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    146. Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett. 2014 Mar 01; 24(5):1274-9. Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA. PMID: 24507921.
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    147. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis. 2014 Jul 01; 210(1):154-7. Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. PMID: 24446524.
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    148. 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):756-9. Raj R, Gut J, Rosenthal PJ, Kumar V. PMID: 24424135.
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    149. Changes at our journal. Am J Trop Med Hyg. 2014 Jan; 90(1):1-2. Rosenthal PJ. PMID: 24402700.
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    150. Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Bioanalysis. 2014; 6(23):3081-9. Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. PMID: 25529877.
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    151. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett. 2014 Feb 13; 5(2):108-12. Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. PMID: 24900781.
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    152. Urea/oxalamide tethered ß-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation. Eur J Med Chem. 2014 Jan; 71:128-34. Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V. PMID: 24287561.
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    153. 4-Aminoquinoline-ß-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. Chem Biol Drug Des. 2014 Feb; 83(2):191-7. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V. PMID: 24034147.
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    154. Novel anti-plasmodial hits identified by virtual screening of the ZINC database. J Comput Aided Mol Des. 2013 Oct; 27(10):859-71. Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC. PMID: 24158745.
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    155. Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. ACS Med Chem Lett. 2013 Dec 12; 4(12):1198-202. Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. PMID: 24900630.
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    156. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem. 2013 Oct 10; 56(19):7679-90. Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. PMID: 24020770.
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    157. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem. 2013 Nov; 69:872-80. Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F. PMID: 24125849.
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    158. Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents. Eur J Med Chem. 2013 Nov; 69:365-72. Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. PMID: 24077527.
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    159. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malar J. 2013 Sep 11; 12:317. Gong L, Parikh S, Rosenthal PJ, Greenhouse B. PMID: 24025776.
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    160. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 2013; 8(9):e73530. Prasad R, Kolla VK, Legac J, Singhal N, Navale R, Rosenthal PJ, Sijwali PS. PMID: 24023882.
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    161. The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol. 2013 Sep; 89(6):1025-38. Rosenthal PJ. PMID: 23899091.
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    162. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013 Dec; 96:347-52. Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H. PMID: 23863332.
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    163. An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. ChemMedChem. 2013 Sep; 8(9):1528-36. Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. PMID: 23853126.
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    164. Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorg Med Chem. 2013 Sep 01; 21(17):4904-13. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. PMID: 23896611.
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    165. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10; 12:234. Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR. PMID: 23841934.
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    166. An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. J Clin Virol. 2013 Sep; 58(1):276-8. Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C. PMID: 23827788.
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    167. Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites. Antimicrob Agents Chemother. 2013 Sep; 57(9):4245-4251. Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ. PMID: 23796921.
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    168. Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. Mol Inform. 2013 Jul; 32(7):659-70. Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F, Rosenthal PJ, Moreira R, Dos Santos DJ. PMID: 27481771.
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    169. Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. J Clin Microbiol. 2013 Aug; 51(8):2564-70. LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ. PMID: 23720790.
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    170. Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem. 2013 Jun 13; 56(11):4811-5. Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. PMID: 23701465.
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    171. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. ACS Med Chem Lett. 2013 Jul 11; 4(7):637-41. Njogu PM, Gut J, Rosenthal PJ, Chibale K. PMID: 24900723.
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    172. Synthesis, Antiplasmodial Activity, and ß-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. ACS Med Chem Lett. 2013 Jul 11; 4(7):642-6. Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K. PMID: 24900724.
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    173. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul; 57(7):3131-6. Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. PMID: 23629719.
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    174. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 01; 21(13):3667-73. Marques AF, Esser D, Rosenthal PJ, Kassack MU, Lima LM. PMID: 23680445.
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    175. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation. Eur J Med Chem. 2013 Apr; 62:590-6. Raj R, Singh P, Singh P, Gut J, Rosenthal PJ, Kumar V. PMID: 23434528.
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    176. Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. Am J Trop Med Hyg. 2013 Apr; 88(4):744-6. Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G. PMID: 23358639.
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    177. Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. Mol Biochem Parasitol. 2013 Feb; 187(2):111-6. Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML, Rosenthal PJ, Juliano L, Carmona AK. PMID: 23354130.
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    178. N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads. J Med Chem. 2013 Jan 24; 56(2):556-67. Pérez BC, Teixeira C, Albuquerque IS, Gut J, Rosenthal PJ, Gomes JR, Prudêncio M, Gomes P. PMID: 23273038.
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    179. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012 Dec 28; 11:435. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. PMID: 23273022.
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    180. In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. Bioorg Med Chem Lett. 2013 Feb 01; 23(3):610-3. Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J, Rosenthal PJ, Prudêncio M, Gomes P. PMID: 23290049.
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    181. Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. PLoS One. 2012; 7(12):e52571. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. PMID: 23285095.
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    182. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. Am J Trop Med Hyg. 2013 Feb; 88(2):289-91. Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. PMID: 23249688.
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    183. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. PMID: 23234548.
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    184. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29; 367(22):2110-8. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. PMID: 23190222.
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    185. Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo. Malar J. 2012 Nov 21; 11:382. Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ. PMID: 23171238.
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    186. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):310-6. Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT. PMID: 22918158.
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    187. 1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues. ACS Med Chem Lett. 2012 Dec 13; 3(12):1029-33. Lu X, Altharawi A, Gut J, Rosenthal PJ, Long TE. PMID: 24936235.
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    188. Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. ChemMedChem. 2012 Sep; 7(9):1537-40. Pérez B, Teixeira C, Gut J, Rosenthal PJ, Gomes JR, Gomes P. PMID: 22753234.
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    189. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):5046-50. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. PMID: 22749280.
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    190. Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials. Eur J Med Chem. 2012 Aug; 54:887-99. Pérez BC, Teixeira C, Figueiras M, Gut J, Rosenthal PJ, Gomes JR, Gomes P. PMID: 22683112.
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    191. Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins. Malar J. 2012 May 07; 11:156. Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML. PMID: 22564457.
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    192. Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis. J Chem Inf Model. 2012 Mar 26; 52(3):696-710. Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA. PMID: 22332946.
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    193. Phosphonium lipocations as antiparasitic agents. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2976-9. Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ. PMID: 22414614.
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    194. Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood. 2012 Apr 19; 119(16):3808-14. Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B. PMID: 22327223.
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    195. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr; 54(7):1001-9. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. PMID: 22308272.
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    196. How do we best diagnose malaria in Africa? Am J Trop Med Hyg. 2012 Feb; 86(2):192-193. Rosenthal PJ. PMID: 22302846.
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    197. The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012; 7(7):699-708. Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J. PMID: 23293660.
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    198. Novel potent metallocenes against liver stage malaria. Antimicrob Agents Chemother. 2012 Mar; 56(3):1564-70. Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal PJ, Prudêncio M, Gomes P. PMID: 22155838.
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    199. Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from ß-lactams and 7-chloroquinoline using click chemistry. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):57-61. Singh P, Singh P, Kumar M, Gut J, Rosenthal PJ, Kumar K, Kumar V, Mahajan MP, Bisetty K. PMID: 22172698.
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    200. Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. Am J Trop Med Hyg. 2011 Nov; 85(5):793-804. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ. PMID: 22049029.
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    201. The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Trans R Soc Trop Med Hyg. 2012 Jan; 106(1):35-42. Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ. PMID: 22018600.
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    202. Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. Bioorg Med Chem. 2011 Dec 15; 19(24):7635-42. Glória PM, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. PMID: 22071522.
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    203. Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 2011 Oct 01; 204(7):1120-4. Baliraine FN, Rosenthal PJ. PMID: 21881128.
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    204. Identification of new antimalarial leads by use of virtual screening against cytochrome bc1. Bioorg Med Chem. 2011 Nov 01; 19(21):6302-8. Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC. PMID: 21958736.
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    205. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Nov; 55(11):5073-7. Nsanzabana C, Rosenthal PJ. PMID: 21876053.
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    206. Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola. Malar J. 2011 Aug 24; 10:248. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 21864379.
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    207. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Chemother. 2011 Oct; 55(10):4698-706. Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. PMID: 21807973.
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    208. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants. Parasitol Res. 2012 Jan; 110(1):109-17. Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E, Rosenthal PJ. PMID: 21739316.
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    209. Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Acta Trop. 2012 Mar; 121(3):196-201. Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 21756863.
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    210. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis. 2011 Jul 01; 204(1):19-26. Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. PMID: 21628654.
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    211. Lessons from sickle cell disease in the treatment and control of malaria. N Engl J Med. 2011 Jun 30; 364(26):2549-51. Rosenthal PJ. PMID: 21714653.
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    212. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11405-10. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L. PMID: 21709259.
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    213. Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. ChemMedChem. 2011 Sep 05; 6(9):1581-6. Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C, Rosenthal PJ, Schmuck C. PMID: 21678556.
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    214. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24; 10:144. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. PMID: 21609473.
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    215. Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. J Med Chem. 2011 May 26; 54(10):3637-49. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. PMID: 21500839.
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    216. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521.
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    217. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. J Chem Inf Model. 2011 Apr 25; 51(4):852-64. Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA. PMID: 21428453.
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    218. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar; 121(3):184-95. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 21420377.
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    219. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2055-8. Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. PMID: 21376591.
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    220. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. PMID: 21262276.
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    221. Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol. 2011 Apr 12; 134(3):717-24. Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. PMID: 21256952.
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    222. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011 Mar; 46(3):927-33. Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R. PMID: 21295887.
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    223. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. PMID: 21207937.
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    224. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. ChemMedChem. 2011 Jan 03; 6(1):141-52. Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S, Rosenthal PJ, Gut J, Morschhäuser J, Bringmann G, Schirmeister T. PMID: 21082722.
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    225. Falcipains and other cysteine proteases of malaria parasites. Adv Exp Med Biol. 2011; 712:30-48. Rosenthal PJ. PMID: 21660657.
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    226. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. J Acquir Immune Defic Syndr. 2011 Jan 01; 56(1):44-50. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. PMID: 21099693.
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    227. FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. Int J Parasitol. 2011 Mar; 41(3-4):363-72. Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR. PMID: 21168413.
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    228. Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents. Bioorg Med Chem Lett. 2011 Jan 15; 21(2):644-51. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J. PMID: 21195617.
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    229. Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. Malar J. 2010 Dec 08; 9:355. Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F. PMID: 21143867.
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    230. Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. Parasitol Res. 2011 May; 108(5):1211-7. Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. PMID: 21107862.
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    231. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb; 55(2):615-22. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. PMID: 21078941.
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    232. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010 Nov 11; 53(21):7864-8. Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. PMID: 20945914.
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    233. Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Nov; 55(3):330-5. Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV. PMID: 20592617.
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    234. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorg Med Chem. 2010 Dec 01; 18(23):8243-56. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. PMID: 21044845.
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    235. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem. 2010 Nov 25; 53(22):8202-6. Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. PMID: 20979352.
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    236. Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. PLoS One. 2010 Oct 19; 5(10):e13438. Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG. PMID: 20976051.
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    237. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis. 2010 Oct 12; 4(10):e849. Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. PMID: 20967286.
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    238. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. PMID: 20863855.
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    239. Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series. J Med Chem. 2010 Aug 26; 53(16):6129-52. Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. PMID: 20672841.
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    240. Bis-alkylamine quindolone derivatives as new antimalarial leads. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5634-7. Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J, Rosenthal PJ, Moreira R, Paulo A. PMID: 20801652.
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    241. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS. 2010 Jul 31; 24(12):1945-52. Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED. PMID: 20543656.
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    242. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. PLoS One. 2010 Jul 30; 5(7):e11759. Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 20689585.
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    243. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. J Inorg Biochem. 2010 Oct; 104(10):1079-83. Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. PMID: 20621360.
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    244. Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Malar J. 2010 Jun 23; 9:177. Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G. PMID: 20573194.
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    245. Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. Malar J. 2010 Jun 18; 9:174. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 20565881.
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    246. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. PMID: 20485428.
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    247. Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS One. 2010 Apr 19; 5(4):e10227. Sijwali PS, Rosenthal PJ. PMID: 20419102.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    248. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. Antimicrob Agents Chemother. 2010 May; 54(5):1949-54. Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ. PMID: 20231394.
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    249. Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem. 2010 Mar 11; 53(5):1951-63. Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T. PMID: 20131843.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    250. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2234-7. Hans RH, Gut J, Rosenthal PJ, Chibale K. PMID: 20206517.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    251. Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda. Malar J. 2010 Jan 15; 9:19. Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B. PMID: 20074380.
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    252. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 2010 Mar; 54(3):1200-6. Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. PMID: 20065051.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCTClinical Trials
    253. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):942-4. Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. PMID: 20045640.
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    254. Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem. 2009 Dec 10; 52(23):7800-7. Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. PMID: 19799426.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    255. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 2009 Dec 01; 200(11):1650-7. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. PMID: 19905933.
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    256. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis. 2009 Dec 01; 49(11):1629-37. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. PMID: 19877969.
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    257. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J. 2009 Nov 14; 8:254. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D. PMID: 19912657.
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    258. Antimalarial activity of azadipeptide nitriles. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):252-5. Löser R, Gut J, Rosenthal PJ, Frizler M, Gütschow M, Andrews KT. PMID: 19913414.
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    259. Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Antimicrob Agents Chemother. 2010 Jan; 54(1):52-9. Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F. PMID: 19841149.
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    260. Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. PLoS One. 2009 Sep 30; 4(9):e7246. Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S. PMID: 19789650.
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    261. On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. J Med Chem. 2009 Sep 24; 52(18):5662-72. Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C. PMID: 19715342.
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    262. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials. 2010 Jan; 31(1):62-70. Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J. PMID: 19761871.
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    263. Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children. Malar J. 2009 Sep 15; 8:213. Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 19754955.
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    264. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. J Infect Dis. 2009 Aug 01; 200(3):430-8. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN. PMID: 19534596.
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    265. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009 Aug 01; 51(4):424-9. German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT. PMID: 19506482.
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    266. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ. 2009 Jul 21; 339:b2763. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO. PMID: 19622553.
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    267. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. PMID: 19620707.
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    268. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. PMID: 19648008.
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    269. Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. Malar J. 2009 Jun 29; 8:145. Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J, Rosenthal PJ. PMID: 19563665.
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    270. Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. PLoS One. 2009 May 27; 4(5):e5694. Pandey KC, Barkan DT, Sali A, Rosenthal PJ. PMID: 19479029.
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    271. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3476-80. Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. PMID: 19467600.
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    272. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. Bioorg Med Chem Lett. 2009 Jun 15; 19(12):3229-32. Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. PMID: 19435664.
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    273. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One. 2009; 4(4):e5156. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. PMID: 19357776.
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    274. Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet. 2009 May 09; 373(9675):1623-31. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ. PMID: 19362361.
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    275. Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo. Am J Trop Med Hyg. 2009 Apr; 80(4):555-8. Mobula L, Lilley B, Tshefu AK, Rosenthal PJ. PMID: 19346374.
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    276. Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. J Ethnopharmacol. 2009 Jun 25; 123(3):483-8. Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. PMID: 19442463.
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    277. Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C J Biosci. 2009 Mar-Apr; 64(3-4):210-4. Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J, Rosenthal PJ, Lobstein A, Tsamo E. PMID: 19526714.
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    278. Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis. 2009 Mar 01; 199(5):758-65. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 19199542.
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    279. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem. 2009 Feb 12; 52(3):852-7. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. PMID: 19128015.
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    280. The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda. AIDS Res Hum Retroviruses. 2009 Jan; 25(1):65-71. Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H. PMID: 19182922.
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    281. Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules. 2008 Dec 23; 14(1):19-35. Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C. PMID: 19104483.
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    282. Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec; 21(6):668-72. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. PMID: 18978536.
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    283. Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis. 2008 Nov 15; 198(10):1554-7. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ. PMID: 18808336.
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    284. Human genetics and malaria: relevance for the design of clinical trials. J Infect Dis. 2008 Nov 01; 198(9):1255-7. Parikh S, Rosenthal PJ. PMID: 18752442.
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    285. Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. Eur J Med Chem. 2009 Apr; 44(4):1457-62. Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J, Rosenthal PJ. PMID: 19036479.
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    286. Experimental malaria infection triggers early expansion of natural killer cells. Infect Immun. 2008 Dec; 76(12):5873-82. Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL. PMID: 18824529.
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    287. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis. 2008 Aug 01; 198(3):393-400. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 18522503.
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    288. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One. 2008 Jun 11; 3(6):e2390. Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H. PMID: 18545692.
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    289. Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J. 2008 Jun 11; 7:106. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG. PMID: 18547415.
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    290. Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J. 2008 Jun 11; 7:107. Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO. PMID: 18547416.
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    291. HIV RNA suppression among HIV-infected Ugandan children with measles. J Acquir Immune Defic Syndr. 2008 Jun 01; 48(2):225-7. Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV. PMID: 18520684.
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    292. Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4150-3. Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P. PMID: 18539459.
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    293. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One. 2008 May 21; 3(5):e2252. Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D. PMID: 18493601.
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    294. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4210-4. Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM. PMID: 18554905.
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    295. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 2008 Jun; 24(6):279-84. Dahl EL, Rosenthal PJ. PMID: 18450512.
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    296. Artesunate for the treatment of severe falciparum malaria. N Engl J Med. 2008 Apr 24; 358(17):1829-36. Rosenthal PJ. PMID: 18434652.
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    297. Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2008 Jun; 52(6):2212-22. Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA. PMID: 18411325.
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    298. High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008 Apr 01; 46(7):985-91. Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G. PMID: 18444813.
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    299. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar; 56(3):374-7. Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J, Rosenthal PJ. PMID: 18310952.
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    300. Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 09; 283(19):12870-6. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. PMID: 18308731.
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    301. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis. 2008 Feb 15; 197(4):510-8. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. PMID: 18240951.
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    302. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. Chem Pharm Bull (Tokyo). 2008 Feb; 56(2):222-6. Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E, Rosenthal PJ, Sewald N. PMID: 18239315.
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    303. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1378-81. Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. PMID: 18207399.
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    304. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics. 2008 Jan; 121(1):e58-64. Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J. PMID: 18166545.
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    305. HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. J Acquir Immune Defic Syndr. 2007 Dec 15; 46(5):624-30. Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G. PMID: 18043317.
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    306. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):485-8. Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. PMID: 18077165.
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    307. Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. J Trop Pediatr. 2008 Feb; 54(1):6-13. Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H. PMID: 17984125.
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    308. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis. 2007 Dec 01; 45(11):1453-61. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB. PMID: 17990228.
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    309. Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6434-8. Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K. PMID: 17949976.
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    310. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007 Oct 01; 21(15):2059-66. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. PMID: 17885296.
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    311. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007 Sep 06; 6:121. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. PMID: 17822535.
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    312. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother. 2007 Oct; 51(10):3485-90. Dahl EL, Rosenthal PJ. PMID: 17698630.
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    313. Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides. ChemMedChem. 2007 Aug; 2(8):1214-24. Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J, Rosenthal PJ, Schirmeister T. PMID: 17562535.
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    314. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrob Agents Chemother. 2007 Sep; 51(9):3096-103. Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 17591848.
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    315. Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. J Biol Chem. 2007 Aug 24; 282(34):24961-9. Subramanian S, Sijwali PS, Rosenthal PJ. PMID: 17565983.
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    316. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 2007 Aug; 51(8):3023-5. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. PMID: 17562798.
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    317. Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg. 2007 Jun; 76(6):1092-7. Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. PMID: 17556616.
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    318. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA. 2007 May 23; 297(20):2210-9. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. PMID: 17519410.
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    319. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials. 2007 May 18; 2(5):e20. Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. PMID: 17525792.
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    320. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
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    321. A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2. Protein Eng Des Sel. 2007 Apr; 20(4):171-7. Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ. PMID: 17430972.
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    322. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clin Infect Dis. 2007 Mar 15; 44(6):889-91. German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. PMID: 17304470.
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    323. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug; 82(2):197-203. Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. PMID: 17361129.
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    324. Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae). Chem Pharm Bull (Tokyo). 2007 Mar; 55(3):464-7. Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J, Rosenthal PJ, Donald Connolly J. PMID: 17329893.
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    325. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet. 2007 Feb 10; 369(9560):491-8. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. PMID: 17292769.
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    326. Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. Eur J Med Chem. 2007 Jun; 42(6):735-42. León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J, Rosenthal PJ, Domínguez JN. PMID: 17321641.
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    327. The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Malar J. 2006 Dec 14; 5:122. Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G. PMID: 17169157.
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    328. Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog. 2006 Nov; 2(11):e117. Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ. PMID: 17083274.
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    329. Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg. 2006 Nov; 75(5):836-42. Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G. PMID: 17123974.
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    330. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. Bioorg Med Chem. 2007 Jan 01; 15(1):273-82. Chipeleme A, Gut J, Rosenthal PJ, Chibale K. PMID: 17052908.
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    331. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep; 50(9):3124-31. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ. PMID: 16940111.
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    332. Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Am J Trop Med Hyg. 2006 Sep; 75(3):375-80. Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 16968909.
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    333. False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. J Clin Microbiol. 2006 Aug; 44(8):3021-4. Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED. PMID: 16891532.
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    334. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794.
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    335. Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):96-106. Sijwali PS, Koo J, Singh N, Rosenthal PJ. PMID: 16890302.
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    336. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg. 2006 Jul; 75(1):162-5. Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. PMID: 16837725.
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    337. Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin. Antimicrob Agents Chemother. 2006 Jun; 50(6):2207-9. Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE, Rosenthal PJ. PMID: 16723585.
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    338. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Trop Med Int Health. 2006 Jun; 11(6):789-99. Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G. PMID: 16771999.
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    339. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials. 2006 May; 1(1):e7. Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG. PMID: 16871329.
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    340. Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. Bioorg Med Chem Lett. 2006 Aug 01; 16(15):4115-9. Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. PMID: 16697641.
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    341. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorg Med Chem. 2006 Aug 15; 14(16):5605-15. Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. PMID: 16690319.
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    342. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 2006 May; 50(5):1893-5. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. PMID: 16641472.
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    343. Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg. 2006 May; 74(5):758-61. Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 16687676.
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    344. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15; 193(8):1160-3. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. PMID: 16544257.
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    345. Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem. 2006 Mar 09; 49(5):1576-84. Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M. PMID: 16509575.
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    346. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis. 2006 Apr 01; 193(7):978-86. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. PMID: 16518760.
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    347. CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006 Jan; 74(1):41-3. Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G. PMID: 16407344.
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    348. Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f. Phytochemistry. 2006 Feb; 67(3):302-6. Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J, Rosenthal PJ, Connolly JD. PMID: 16368120.
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    349. Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'. Exp Parasitol. 2006 Mar; 112(3):187-92. Singh N, Sijwali PS, Pandey KC, Rosenthal PJ. PMID: 16337629.
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    350. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis. 2006 Jan 01; 193(1):9-15. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. PMID: 16323126.
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    351. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Am J Trop Med Hyg. 2005 Nov; 73(5):826-32. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. PMID: 16282288.
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    352. Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Am J Trop Med Hyg. 2005 Aug; 73(2):256-62. Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G. PMID: 16103584.
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    353. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med. 2005 Jul; 2(7):e190. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. PMID: 16033307.
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    354. Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother. 2005 Jul; 49(7):2983-5. Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. PMID: 15980379.
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    355. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. PMID: 15964982.
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    356. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem. 2005 May 19; 48(10):3654-8. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. PMID: 15887974.
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    357. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005 May 02; 13(9):3249-61. Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. PMID: 15809160.
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    358. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg. 2005 May; 72(5):573-80. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. PMID: 15891132.
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    359. Synthesis and antimalarial activity of sulfonamide chalcone derivatives. Farmaco. 2005 Apr; 60(4):307-11. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. PMID: 15848205.
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    360. Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2005 Feb; 139(2):205-12. Dahl EL, Rosenthal PJ. PMID: 15664655.
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    361. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. PMID: 15582423.
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    362. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg. 2004 Dec; 71(6):758-63. Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ. PMID: 15642967.
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    363. Cysteine proteases of malaria parasites. Int J Parasitol. 2004 Dec; 34(13-14):1489-99. Rosenthal PJ. PMID: 15582526.
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    364. Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg. 2004 Dec; 71(6):750-3. Parikh S, Dorsey G, Rosenthal PJ. PMID: 15642965.
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    365. Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet. 2004 Nov 27-Dec 3; 364(9449):1950-7. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. PMID: 15567011.
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    366. Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors. Parasitol Res. 2004 Oct; 94(4):312-7. Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y. PMID: 15372231.
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    367. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2004 Sep; 48(9):3241-5. Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K. PMID: 15328079.
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    368. Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. Bioorg Med Chem Lett. 2004 Aug 02; 14(15):3901-5. Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. PMID: 15225694.
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    369. Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. J Biol Chem. 2004 Aug 20; 279(34):35236-41. Singh A, Rosenthal PJ. PMID: 15192087.
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    370. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
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    371. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004 Jun; 3(6):509-20. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. PMID: 15173840.
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    372. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8721-6. Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ. PMID: 15166288.
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    373. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis. 2004 Jun 15; 189(12):2220-6. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 15181569.
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    374. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health. 2004 May; 9(5):624-9. Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 15117308.
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    375. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4384-9. Sijwali PS, Rosenthal PJ. PMID: 15070727.
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    376. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J. 2004 Mar 01; 378(Pt 2):529-38. Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. PMID: 14629194.
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    377. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry. 2003 Dec; 64(7):1269-75. Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. PMID: 14599525.
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    378. Antimalarial activities of novel synthetic cysteine protease inhibitors. Antimicrob Agents Chemother. 2003 Dec; 47(12):3810-4. Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP, Rosenthal PJ. PMID: 14638488.
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    379. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrob Agents Chemother. 2003 Dec; 47(12):3806-9. Locher CP, Ruben PC, Gut J, Rosenthal PJ. PMID: 14638487.
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    380. Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J Biol Chem. 2004 Jan 30; 279(5):3484-91. Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ. PMID: 14625277.
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    381. Antimalarial drug discovery: old and new approaches. J Exp Biol. 2003 Nov; 206(Pt 21):3735-44. Rosenthal PJ. PMID: 14506208.
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    382. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 14505663.
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    383. Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. J Infect Dis. 2003 Oct 15; 188(8):1231-8. Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ. PMID: 14551894.
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    384. Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Am J Trop Med Hyg. 2003 Sep; 69(3):247-52. Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 14628939.
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    385. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg. 2003 Sep; 69(3):244-6. Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 14628938.
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    386. Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines. Bioorg Med Chem. 2003 May 15; 11(10):2293-9. Batra S, Sabnis YA, Rosenthal PJ, Avery MA. PMID: 12713840.
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    387. Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. Protein Sci. 2003 Mar; 12(3):501-9. Sabnis YA, Desai PV, Rosenthal PJ, Avery MA. PMID: 12592020.
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    388. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2003 Feb; 68(2):127-32. Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. PMID: 12641399.
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    389. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg. 2003 Feb; 68(2):133-9. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 12641400.
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    390. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrob Agents Chemother. 2003 Jan; 47(1):154-60. Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. PMID: 12499184.
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    391. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet. 2002 Dec 21-28; 360(9350):2031-8. Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ. PMID: 12504399.
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    392. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem J. 2002 Nov 15; 368(Pt 1):273-81. Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. PMID: 12169096.
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    393. Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases. Mol Biochem Parasitol. 2002 Jun; 122(1):99-104. Shenai BR, Rosenthal PJ. PMID: 12076775.
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    394. Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen. Bioorg Med Chem Lett. 2002 May 20; 12(10):1351-5. Park BS, Kim DY, Rosenthal PJ, Huh SC, Lee BJ, Park E-, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE. PMID: 11992775.
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    395. Stage-specific antimalarial activity of cysteine protease inhibitors. Biol Chem. 2002 May; 383(5):843-7. Shenai BR, Semenov AV, Rosenthal PJ. PMID: 12108550.
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    396. Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors. J Biomol Struct Dyn. 2002 Apr; 19(5):765-74. Sabnis Y, Rosenthal PJ, Desai P, Avery MA. PMID: 11922834.
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    397. Hydrolysis of erythrocyte proteins by proteases of malaria parasites. Curr Opin Hematol. 2002 Mar; 9(2):140-5. Rosenthal PJ. PMID: 11844998.
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    398. Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain. J Biol Chem. 2002 Apr 26; 277(17):14910-5. Sijwali PS, Shenai BR, Rosenthal PJ. PMID: 11827964.
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    399. Cysteine proteases of malaria parasites: targets for chemotherapy. Curr Pharm Des. 2002; 8(18):1659-72. Rosenthal PJ, Sijwali PS, Singh A, Shenai BR. PMID: 12132997.
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    400. Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem J. 2001 Dec 01; 360(Pt 2):481-9. Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ. PMID: 11716777.
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    401. The impact of whole genome sequence data on drug discovery--a malaria case study. Mol Med. 2001 Oct; 7(10):698-710. Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE. PMID: 11713369.
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    402. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Lancet. 2001 Aug 04; 358(9279):368-74. Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ. PMID: 11502317.
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    403. Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expr Purif. 2001 Jun; 22(1):128-34. Sijwali PS, Brinen LS, Rosenthal PJ. PMID: 11388810.
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    404. Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis. 2001 May 01; 183(9):1417-20. Dorsey G, Kamya MR, Singh A, Rosenthal PJ. PMID: 11294677.
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    405. Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum. Antimicrob Agents Chemother. 2001 Mar; 45(3):949-51. Singh A, Rosenthal PJ. PMID: 11181388.
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    406. The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Trans R Soc Trop Med Hyg. 2001 Jan-Feb; 95(1):50-5. Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Babirye JN, Staedke SG, Rosenthal PJ. PMID: 11280066.
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    407. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J Biol Chem. 2000 Sep 15; 275(37):29000-10. Shenai BR, Sijwali PS, Singh A, Rosenthal PJ. PMID: 10887194.
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    408. Difficulties in the prevention, diagnosis, and treatment of imported malaria. Arch Intern Med. 2000 Sep 11; 160(16):2505-10. Dorsey G, Gandhi M, Oyugi JH, Rosenthal PJ. PMID: 10979063.
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    409. Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2000 Jun; 62(6):686-92. Dorsey G, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET, Rosenthal PJ. PMID: 11304055.
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    410. Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. Bioorg Med Chem. 1999 Apr; 7(4):633-8. Olson JE, Lee GK, Semenov A, Rosenthal PJ. PMID: 10353642.
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    411. Proteases of protozoan parasites. Adv Parasitol. 1999; 43:105-59. Rosenthal PJ. PMID: 10214691.
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    412. Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):253-7. Rosenthal PJ, Semenov A, Ploplis VA, Plow EF. PMID: 9879906.
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    413. Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep; 42(9):2254-8. Semenov A, Olson JE, Rosenthal PJ. PMID: 9736544.
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    414. Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases. Mol Biochem Parasitol. 1998 Sep 01; 95(1):153-8. Gor DO, Li AC, Wiser MF, Rosenthal PJ. PMID: 9763298.
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    415. Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei. Vaccine. 1998 Jul; 16(11-12):1193-202. Gor DO, Li AC, Rosenthal PJ. PMID: 9682379.
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    416. Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum. J Infect Dis. 1998 Jul; 178(1):285-8. Gor DO, Rosenthal PJ. PMID: 9652457.
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    417. Proteases of malaria parasites: new targets for chemotherapy. Emerg Infect Dis. 1998 Jan-Mar; 4(1):49-57. Rosenthal PJ. PMID: 9452398.
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    418. Hemoglobin catabolism and iron utilization by malaria parasites. Mol Biochem Parasitol. 1996 Dec 20; 83(2):131-9. Rosenthal PJ, Meshnick SR. PMID: 9027746.
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    419. Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. Antimicrob Agents Chemother. 1996 Jul; 40(7):1600-3. Rosenthal PJ, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D. PMID: 8807047.
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    420. Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites. Blood. 1996 May 15; 87(10):4448-54. Gamboa de Domínguez ND, Rosenthal PJ. PMID: 8639807.
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    421. Conservation of key amino acids among the cysteine proteinases of multiple malarial species. Mol Biochem Parasitol. 1996 Jan; 75(2):255-60. Rosenthal PJ. PMID: 8992323.
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    422. Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. Infect Immun. 1995 Jun; 63(6):2120-5. Salas F, Fichmann J, Lee GK, Scott MD, Rosenthal PJ. PMID: 7768590.
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    423. Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. Exp Parasitol. 1995 Mar; 80(2):272-81. Rosenthal PJ. PMID: 7895837.
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    424. Anti-malarial drug development using models of enzyme structure. Chem Biol. 1994 Sep; 1(1):31-7. Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R, Rosenthal PJ. PMID: 9383368.
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    425. Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases. J Mol Biol. 1994 Aug 12; 241(2):312-6. Rosenthal PJ, Ring CS, Chen X, Cohen FE. PMID: 8057374.
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    426. A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue. Biochim Biophys Acta. 1993 Apr 29; 1173(1):91-3. Rosenthal PJ. PMID: 8485161.
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    427. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar; 91(3):1052-6. Rosenthal PJ, Lee GK, Smith RE. PMID: 8450035.
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    428. Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. Mol Biochem Parasitol. 1992 Mar; 51(1):143-52. Rosenthal PJ, Nelson RG. PMID: 1565129.
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    429. Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase. J Clin Invest. 1991 Nov; 88(5):1467-72. Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D. PMID: 1939639.
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    430. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15; 35(2):177-83. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. PMID: 2671722.
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    431. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov; 82(5):1560-6. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. PMID: 3053784.
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    432. Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome. Am J Med. 1988 Feb; 84(2):307-9. Rosenthal PJ, Chaisson RE, Hadley WK, Leech JH. PMID: 3407656.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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