Philip Rosenthal, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-8845
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1988 Medicine
    University of California, San Francisco Clinical Fellowship Infectious Diseases
    University of MichiganResidency School of Medicine

    Collapse Overview 
    Collapse Overview
    We have three main areas of interest, all involving malaria, one of the most important infections of humans. First, we study the basic biology of malaria parasites, including the biochemical properties and biological roles of parasite proteases and mechanisms of action of novel antimalarial agents. Second, in collaboration with industry and academic groups, we are pursuing drug discovery, evaluating protease inhibitors, oxaboroles, and other compounds as potential antimalarial drugs. Third, we study malaria in Africa, with translational and laboratory studies at UCSF and in Uganda and Burkina Faso evaluating antimalarial drug efficacy and resistance, the molecular epidemiology of malaria, the roles of host and parasite genetic polymorphisms in treatment outcomes, antimalarial pharmacokinetics and pharmacodynamics, and related areas. Finally, a new area of interest is using genetic tools to characterize causes of febrile illness in African children. In other activities, Dr. Rosenthal is Editor-in-Chief of the American Journal of Tropical Medicine and Hygiene; Chair, Scientific Advisory Committee, WorldWide Antimalarial Resistance Network; Member, Scientific Board, Infectious Diseases Data Observatory; and a member of the World Health Organization Technical Expert Group on Malaria Chemotherapy.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda
    NIH U01AI141308Apr 15, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline
    NIH R01AI139179Jun 22, 2018 - May 31, 2023
    Role: Principal Investigator
    Pharmacological insights into antimalarial exposure, clinical outcomes, and drug resistance in Africa
    NIH R01AI117001Feb 10, 2015 - Apr 30, 2025
    Role: Principal Investigator
    Discovery of Oxaboroles as New Antimalarial Agents
    NIH R01AI095324Apr 1, 2012 - Mar 31, 2019
    Role: Principal Investigator
    Discovery of Oxaboroles as New Antimalarial Agents
    NIH R56AI095324Sep 30, 2011 - Mar 31, 2012
    Role: Principal Investigator
    Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    NIH R56AI075045Aug 1, 2008 - Jul 31, 2009
    Role: Principal Investigator
    Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies in Uganda
    NIH R01AI075045Jul 1, 2007 - Aug 31, 2025
    Role: Principal Investigator
    Training In Malaria Research in Uganda
    NIH D43TW007375Sep 16, 2005 - Jan 31, 2021
    Role: Principal Investigator
    Clinical &Molecular Studies of Drug Resistant Malaria
    NIH U01AI052142Jul 1, 2002 - Aug 31, 2009
    Role: Principal Investigator
    TRAINING IN MALARIA RESEARCH IN UGANDA
    NIH D43TW001506Sep 29, 2000 - Feb 28, 2009
    Role: Principal Investigator
    MOLECULAR APPROACHES TO DRUG RESISTANT MALARIA
    NIH R03AI043301Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH P01AI035707May 1, 1995 - May 31, 2010
    Role: Co-Investigator
    PROTEINASE-LIKE MALARIAL ANTIGENS
    NIH U01AI036463Sep 15, 1994 - Aug 31, 1998
    Role: Principal Investigator
    Falcipain Cysteine Proteases of Malaria Parasites
    NIH R56AI035800Jul 1, 1994 - May 31, 2008
    Role: Principal Investigator
    EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    NIH R01AI035800Jul 1, 1994 - May 31, 2005
    Role: Principal Investigator
    MALARIAL HEMOGLOBINASE
    NIH R29AI035800Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    MOLECULAR APPROACHES TO A MALARIAL CYSTEINE
    NIH K11AI000870Mar 1, 1988 - Feb 28, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nat Commun. 2022 Apr 20; 13(1):2158. de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA, Rosenthal PJ, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. PMID: 35444200; PMCID: PMC9021288.
      View in: PubMed   Mentions:
    2. Malaria in 2022: Challenges and Progress. Am J Trop Med Hyg. 2022 Apr 12. Rosenthal PJ. PMID: 35413687.
      View in: PubMed   Mentions:
    3. Cooperation in Countering Artemisinin Resistance in Africa: Learning from COVID-19. Am J Trop Med Hyg. 2022 Apr 12. Rosenthal PJ, Björkman A, Dhorda M, Djimde A, Dondorp AM, Gaye O, Guerin PJ, Juma E, Kwiatkowski DP, Merson L, Ntoumi F, Price RN, Raman J, Roos DS, Ter Kuile F, Tinto H, Tomko SS, White NJ, Barnes KI. PMID: 35413688.
      View in: PubMed   Mentions:
    4. Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning. Malar J. 2022 Apr 12; 21(1):122. Das D, Vongpromek R, Assawariyathipat T, Srinamon K, Kennon K, Stepniewska K, Ghose A, Sayeed AA, Faiz MA, Netto RLA, Siqueira A, Yerbanga SR, Ouédraogo JB, Callery JJ, Peto TJ, Tripura R, Koukouikila-Koussounda F, Ntoumi F, Ong'echa JM, Ogutu B, Ghimire P, Marfurt J, Ley B, Seck A, Ndiaye M, Moodley B, Sun LM, Archasuksan L, Proux S, Nsobya SL, Rosenthal PJ, Horning MP, McGuire SK, Mehanian C, Burkot S, Delahunt CB, Bachman C, Price RN, Dondorp AM, Chappuis F, Guérin PJ, Dhorda M. PMID: 35413904; PMCID: PMC9004086.
      View in: PubMed   Mentions:
    5. Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity. Eur J Med Chem. 2022 Mar 28; 236:114324. Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM. PMID: 35390711.
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    6. Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr Open. 2022 Nov; 2. Huang L, Sok V, Aslam-Mir U, Marzan F, Whalen M, Rosenthal PJ, Aweeka F. PMID: 35531322; PMCID: PMC9068709.
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    7. Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0143721. Okitwi M, Orena S, Thomas K, Tumwebaze PK, Byaruhanga O, Nsobya SL, Conrad MD, Bayles BR, Rosenthal PJ, Cooper RA. PMID: 35266828; PMCID: PMC9017344.
      View in: PubMed   Mentions:
    8. Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues. ACS Chem Biol. 2022 03 18; 17(3):576-589. Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A, Rosenthal PJ, Schirmeister T, Bauer A, Schäberle TF. PMID: 35262340.
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    9. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. J Med Chem. 2022 03 10; 65(5):3798-3813. Taft BR, Yokokawa F, Kirrane T, Mata AC, Huang R, Blaquiere N, Waldron G, Zou B, Simon O, Vankadara S, Chan WL, Ding M, Sim S, Straimer J, Guiguemde A, Lakshminarayana SB, Jain JP, Bodenreider C, Thompson C, Lanshoeft C, Shu W, Fang E, Qumber J, Chan K, Pei L, Chen YL, Schulz H, Lim J, Abas SN, Ang X, Liu Y, Angulo-Barturen I, Jiménez-Díaz MB, Gamo FJ, Crespo-Fernandez B, Rosenthal PJ, Cooper RA, Tumwebaze P, Aguiar ACC, Campo B, Campbell S, Wagner J, Diagana TT, Sarko C. PMID: 35229610.
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    10. Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries. JAMA Pediatr. 2022 Mar 01; 176(3):e216436. Nachega JB, Sam-Agudu NA, Machekano RN, Rabie H, van der Zalm MM, Redfern A, Dramowski A, O'Connell N, Pipo MT, Tshilanda MB, Byamungu LN, Masekela R, Jeena PM, Pillay A, Gachuno OW, Kinuthia J, Ishoso DK, Amoako E, Agyare E, Agbeno EK, Martyn-Dickens C, Sylverken J, Enimil A, Jibril AM, Abdullahi AM, Amadi O, Umar UM, Sigwadhi LN, Hermans MP, Otokoye JO, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Zumla A, Sewankambo NK, Aanyu HT, Musoke P, Suleman F, Adejumo P, Noormahomed EV, Deckelbaum RJ, Fowler MG, Tshilolo L, Smith G, Mills EJ, Umar LW, Siedner MJ, Kruger M, Rosenthal PJ, Mellors JW, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on C. PMID: 35044430; PMCID: PMC8771438.
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    11. Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. J Infect Dis. 2022 Feb 15; 225(4):696-704. Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ. PMID: 34460932; PMCID: PMC8844592.
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    12. The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. J Infect Dis. 2022 Feb 01; 225(3):470-475. Johnson Valiente A, Liem KS, Schwarz KB, Rosenthal P, Murray KF, Mogul D, Teckman J, Rodriguez-Baez N, Schwarzenberg SJ, Feld JJ, Wong DK, Lewis-Ximenez LL, Lauer G, Hansen BE, Ling SC, Janssen HLA, Gehring AJ. PMID: 34286845.
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    13. Incidence and prediction of HBsAg seroclearance in a prospective multi-ethnic HBeAg-negative chronic hepatitis B cohort. Hepatology. 2022 03; 75(3):709-723. Terrault NA, Wahed AS, Feld JJ, Cooper SL, Ghany MG, Lisker-Melman M, Perrillo R, Sterling RK, Khalili M, Chung RT, Rosenthal P, Fontana RJ, Sarowar A, Lau DTY, Wang J, Lok AS, Janssen HLA. PMID: 34743343; PMCID: PMC8943823.
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    14. Lessons Learned from Children Enrolled into the Hepatitis B Virus Research Network Multi-Center Prospective Study. J Pediatr Gastroenterol Nutr. 2022 Jan 18. Schwarzenberg SJ, Ling SC, Rosenthal P, Murray KF, Teckman J, Mogul D, Rodriguez-Baez N, Schwarz K. PMID: 35045562.
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    15. Artemisinin resistance in Africa: How urgent is the threat? Med (N Y). 2021 12 10; 2(12):1287-1288. Fidock DA, Rosenthal PJ. PMID: 35005674; PMCID: PMC8729812.
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    16. Piperaquine induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women. Clin Infect Dis. 2021 Dec 02. Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR, Clark TD, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. PMID: 34864925.
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    17. Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children. Nat Commun. 2021 11 18; 12(1):6714. Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. PMID: 34795281; PMCID: PMC8602248.
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    18. Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing. Antimicrob Agents Chemother. 2022 01 18; 66(1):e0116321. Kanai M, Yeo T, Asua V, Rosenthal PJ, Fidock DA, Mok S. PMID: 34694871; PMCID: PMC8765236.
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    19. Are Artemisinin-Based Combination Therapies For Malaria Beginning To Fail in Africa? Am J Trop Med Hyg. 2021 09 07; 105(4):857-858. Rosenthal PJ. PMID: 34491214; PMCID: PMC8592154.
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    20. Liver transplant in children and adults with cystic fibrosis: Impact of growth failure and nutritional status. Am J Transplant. 2022 01; 22(1):177-186. Cheng K, Rosenthal P, Roberts JP, Perito ER. PMID: 34379865.
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    21. Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0077121. Kreutzfeld O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, Byaruhanga O, Katairo T, Asua V, Okitwi M, Orena S, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey J, Duffey M, Bayles BR, Vaidya AB, Cooper RA, Rosenthal PJ. PMID: 34339273; PMCID: PMC8448140.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Sci Transl Med. 2021 07 21; 13(603). Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA, Rosenthal PJ, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D. PMID: 34290058; PMCID: PMC8530196.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. Elife. 2021 07 19; 10. Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, Nzoumbou-Boko R, Ndayikunda C, Kabanywanyi AM, Uwimana A, Smith SJ, Kolley O, Ndounga M, Warsame M, Leang R, Nosten F, Anderson TJ, Rosenthal PJ, Ménard D, Fidock DA. PMID: 34279219; PMCID: PMC8321553.
      View in: PubMed   Mentions: 2     Fields:    
    24. Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency. Hepatology. 2021 08; 74(2):892-906. van Wessel DBE, Thompson RJ, Gonzales E, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipinski P, Czubkowski P, Rock N, Shagrani M, Broering D, Algoufi T, Mazhar N, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JBF, Serranti D, Arikan C, Debray D, Lacaille F, Goncalves C, Hierro L, Muñoz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsofi A, Luigi Calvo P, Krebs-Schmitt D, Hartleif S, van der Woerd WL, Wang JS, Li LT, Durmaz Ö, Kerkar N, Hørby Jørgensen M, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Targa Ferreira C, Ordonez F, Wang H, Sency V, Mo Kim K, Chen HL, Carvalho E, Fabre A, Quintero Bernabeu J, Alonso EM, Sokol RJ, Suchy FJ, Loomes KM, McKiernan PJ, Rosenthal P, Turmelle Y, Rao GS, Horslen S, Kamath BM, Rogalidou M, Karnsakul WW, Hansen B, Verkade HJ, Natural Course and Prognosis of PFIC and Effect of Biliary Diversion Consortium. PMID: 33666275; PMCID: PMC8456904.
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    25. Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum. Malar J. 2021 Jun 30; 20(1):292. Duvalsaint M, Conrad MD, Tukwasibwe S, Tumwebaze PK, Legac J, Cooper RA, Rosenthal PJ. PMID: 34193148; PMCID: PMC8247092.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    26. Challenges and opportunities for use of long-lasting insecticidal nets to prevent malaria during overnight travel in Uganda: a qualitative study. Malar J. 2021 Jun 26; 20(1):283. Ekusai-Sebatta D, Arinaitwe E, Mpimbaza A, Nankabirwa JI, Drakeley C, Rosenthal PJ, Staedke SG, Muyinda H. PMID: 34174892; PMCID: PMC8235645.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    27. Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study. Lancet Microbe. 2021 09; 2(9):e441-e449. Tumwebaze PK, Katairo T, Okitwi M, Byaruhanga O, Orena S, Asua V, Duvalsaint M, Legac J, Chelebieva S, Ceja FG, Rasmussen SA, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Bayles BR, Rosenthal PJ, Cooper RA. PMID: 34553183; PMCID: PMC8454895.
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    28. Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study. Lancet Infect Dis. 2021 11; 21(11):1568-1578. Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, Dorsey G, Greenhouse B, Drakeley C, Staedke SG, Bousema T. PMID: 34146476; PMCID: PMC8554388.
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    29. Chronic Hepatitis Is Common and Often Untreated Among Children with Hepatitis B Infection in the United States and Canada. J Pediatr. 2021 10; 237:24-33.e12. Ling SC, Lin HS, Murray KF, Rosenthal P, Mogul D, Rodriguez-Baez N, Schwarzenberg SJ, Teckman J, Schwarz KB, Hepatitis B Research Network (HBRN). PMID: 34022250; PMCID: PMC8478804.
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    30. Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives. RSC Med Chem. 2021 Jun 23; 12(6):970-981. Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S, Rosenthal PJ, Hoda N. PMID: 34223162; PMCID: PMC8221264.
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    31. Non-operative management of biliary complications after Liver Transplantation in pediatric patients: A 30-year experience. Pediatr Transplant. 2021 Sep; 25(6):e14028. Lee AY, Lehrman ED, Perito ER, Kerlan RK, Kohi MP, Kolli KP, Taylor AG, Ostroff JW, Kang SM, Roberts JP, Rhee S, Rosenthal P, Fidelman N. PMID: 33951255.
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    32. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J Med Chem. 2021 05 13; 64(9):6085-6136. Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK, Rosenthal PJ, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N, Winzeler EA, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. PMID: 33876936; PMCID: PMC8171248.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    33. A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies. Bioorg Med Chem. 2021 06 01; 39:116159. Rani A, Sharma A, Legac J, Rosenthal PJ, Singh P, Kumar V. PMID: 33895706.
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    34. Has artemisinin resistance emerged in Africa? Lancet Infect Dis. 2021 08; 21(8):1056-1057. Rosenthal PJ. PMID: 33864802.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda. J Infect Dis. 2021 03 29; 223(6):985-994. Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR, Dorsey G, Nsobya SL, Bailey J, Rosenthal PJ. PMID: 33146722; PMCID: PMC8006419.
      View in: PubMed   Mentions: 8     Fields:    
    36. Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice. Angew Chem Int Ed Engl. 2021 04 19; 60(17):9279-9283. Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Chelebieva S, Tumwebaze PK, Lafuente-Monasterio MJ, Martinez-Martinez MS, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Meinke PT, Nathan CF, Kirkman LA, Lin G. PMID: 33433953; PMCID: PMC8087158.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. Malar J. 2021 Feb 25; 20(1):111. Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR, Dorsey G, Rosenthal PJ, Colucci F, Nakimuli A. PMID: 33632228; PMCID: PMC7908804.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda. Malar J. 2021 Feb 02; 20(1):68. Briggs J, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M, Rodriguez-Barraquer I, Staedke S, Dorsey G, Rosenthal PJ, Greenhouse B. PMID: 33531029; PMCID: PMC8042884.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    39. Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity. Front Immunol. 2020; 11:576663. Ssewanyana I, Rek J, Rodriguez I, Wu L, Arinaitwe E, Nankabirwa JI, Beeson JG, Mayanja-Kizza H, Rosenthal PJ, Dorsey G, Kamya MR, Drakeley C, Greenhouse B, Tetteh KKA. PMID: 33584643; PMCID: PMC7873448.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    40. Prevalence of Malaria Parasite Infections among U.S.-Bound Congolese Refugees with and without Splenomegaly. Am J Trop Med Hyg. 2021 01 18; 104(3):996-999. Mwesigwa M, Webster JL, Nsobya SL, Rowan A, Basnet MS, Phares CR, Weinberg M, Klosovsky A, Naoum M, Rosenthal PJ, Stauffer WM. PMID: 33534754; PMCID: PMC7941850.
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    41. Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda. Malar J. 2021 Jan 02; 20(1):4. Nsobya SL, Walakira A, Namirembe E, Kiggundu M, Nankabirwa JI, Ruhamyankaka E, Arinaitwe E, Conrad MD, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 33386076; PMCID: PMC7777526.
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    42. Year 100 of the American Journal of Tropical Medicine and Hygiene: A Remarkable Year. Am J Trop Med Hyg. 2021 01; 104(1):1-3. Rosenthal PJ. PMID: 33432913; PMCID: PMC7790076.
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    43. Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda. PLoS One. 2020; 15(12):e0243303. Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C, Rosenthal PJ, Kamya M, Dorsey G, Krezanoski PJ. PMID: 33270743; PMCID: PMC7714220.
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    44. Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women. Antimicrob Agents Chemother. 2020 11 17; 64(12). Nayebare P, Asua V, Conrad MD, Kajubi R, Kakuru A, Nankabirwa JI, Muhanguzi D, Dorsey G, Kamya MR, Nsobya S, Rosenthal PJ. PMID: 33020152; PMCID: PMC7674052.
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    45. Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women. Antimicrob Agents Chemother. 2020 11 17; 64(12). Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. PMID: 33020153; PMCID: PMC7674024.
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    46. Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo. Malar J. 2020 Nov 11; 19(1):405. Arinaitwe E, Nankabirwa JI, Krezanoski P, Rek J, Kamya V, Epstein A, Rosenthal PJ, Drakeley C, Kamya MR, Dorsey G, Staedke SG. PMID: 33176793; PMCID: PMC7661187.
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    47. Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase. ACS Infect Dis. 2020 11 13; 6(11):2994-3003. Butler JH, Baptista RP, Valenciano AL, Zhou B, Kissinger JC, Tumwebaze PK, Rosenthal PJ, Cooper RA, Yue JM, Cassera MB. PMID: 32970404.
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    48. Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda. Am J Trop Med Hyg. 2020 10; 103(4):1517-1524. Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C, Dorsey G, Rosenthal PJ, Staedke SG. PMID: 32840203; PMCID: PMC7543847.
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    49. Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda. Antimicrob Agents Chemother. 2020 09 21; 64(10). Cuu G, Asua V, Tukwasibwe S, Nsobya SL, Nanteza A, Kimuda MP, Mpimbaza A, Rosenthal PJ. PMID: 32660999; PMCID: PMC7508615.
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    50. Keep Politics out of Funding Decisions for Medical Research and Public Health. Am J Trop Med Hyg. 2020 09; 103(3):931-932. Rosenthal PJ, Bausch DG, Goraleski KA, Hill DR, Jacobson JA, John CC, Breman JG. PMID: 32700678; PMCID: PMC7470536.
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    51. Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice. Gastroenterology. 2020 11; 159(5):1731-1751.e10. Xanthakos SA, Lavine JE, Yates KP, Schwimmer JB, Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK, Scheimann AO, Miloh T, Fishbein M, Behling CA, Brunt EM, Sanyal AJ, Tonascia J, NASH Clinical Research Network. PMID: 32712103; PMCID: PMC7680281.
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    52. Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension. J Pediatr. 2020 12; 227:81-86.e4. Teckman J, Rosenthal P, Hawthorne K, Spino C, Bass LM, Murray KF, Kerkar N, Magee JC, Karpen S, Heubi JE, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Sherker AH, Sokol RJ, ChiLDReN (Childhood Liver Disease Research Network). PMID: 32663593; PMCID: PMC7686087.
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    53. Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation. Chem Biol Drug Des. 2020 12; 96(6):1355-1361. Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. PMID: 32515142.
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    54. Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cell Mol Immunol. 2020 08; 17(8):799-806. Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F. PMID: 32541835; PMCID: PMC7294524.
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    55. Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean. Am J Trop Med Hyg. 2020 08; 103(2):593-596. Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG, Rosenthal PJ, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG. PMID: 32524963; PMCID: PMC7410452.
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    56. COVID-19: Shining the Light on Africa. Am J Trop Med Hyg. 2020 06; 102(6):1145-1148. Rosenthal PJ, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG. PMID: 32372749; PMCID: PMC7253089.
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    57. Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations. PLoS One. 2020; 15(5):e0233893. Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. PMID: 32470030; PMCID: PMC7259774.
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    58. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. J Med Chem. 2020 06 11; 63(11):6179-6202. Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. PMID: 32390431; PMCID: PMC7354843.
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    59. Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS Infect Dis. 2020 07 10; 6(7):1827-1835. Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR. PMID: 32369341; PMCID: PMC7363035.
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    60. The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. Am J Trop Med Hyg. 2020 08; 103(2):785-792. Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G. PMID: 32431280; PMCID: PMC7410449.
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    61. The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). Am J Trop Med Hyg. 2020 05; 102(5):915-916. Rosenthal PJ. PMID: 32238224; PMCID: PMC7204570.
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    62. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun. 2020 04 30; 11(1):2107. Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. PMID: 32355199; PMCID: PMC7192906.
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    63. Are three drugs for malaria better than two? Lancet. 2020 04 25; 395(10233):1316-1317. Rosenthal PJ. PMID: 32171077.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020 01 28; 11(1). Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ. PMID: 31992618; PMCID: PMC6989105.
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    65. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J. 2020 Jan 15; 19(1):21. Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I. PMID: 31941490; PMCID: PMC6964006.
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    66. Falcipain cysteine proteases of malaria parasites: An update. Biochim Biophys Acta Proteins Proteom. 2020 03; 1868(3):140362. Rosenthal PJ. PMID: 31927030.
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    67. Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights. ACS Med Chem Lett. 2020 Feb 13; 11(2):154-161. Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V. PMID: 32071682; PMCID: PMC7025377.
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    68. Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver. J Pediatr Gastroenterol Nutr. 2020 01; 70(1):79-86. Squires JE, Ng VL, Hawthorne K, Henn LL, Sorensen LG, Fredericks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 31503218; PMCID: PMC6934908.
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    69. Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates. Molecules. 2019 Dec 12; 24(24). Aguiar L, Biosca A, Lantero E, Gut J, Vale N, Rosenthal PJ, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P. PMID: 31842498; PMCID: PMC6943437.
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    70. Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. Future Med Chem. 2020 02; 12(3):193-205. Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. PMID: 31802710; PMCID: PMC7099627.
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    71. Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. Malar J. 2019 Dec 03; 18(1):389. Oldenburg CE, Amza A, Cooley G, Kadri B, Nassirou B, Arnold BF, Rosenthal PJ, O'Brien KS, West SK, Bailey RL, Porco TC, Keenan JD, Lietman TM, Martin DL. PMID: 31796025; PMCID: PMC6889587.
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    72. Malaria parasites fine-tune mutations to resist drugs. Nature. 2019 12; 576(7786):217-219. Tilley L, Rosenthal PJ. PMID: 31822828.
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    73. Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. Am J Trop Med Hyg. 2019 12; 101(6):1424-1433. Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS. PMID: 31595873; PMCID: PMC6896879.
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    74. Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates. Bioorg Med Chem Lett. 2020 01 15; 30(2):126810. Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V. PMID: 31740250.
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    75. Be Careful What You Eat! Am J Trop Med Hyg. 2019 11; 101(5):955-956. Rosenthal PJ. PMID: 31549613; PMCID: PMC6838582.
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    76. [(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity. EXCLI J. 2019; 18:962-987. de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J, Rosenthal PJ, Gut J. PMID: 31762723; PMCID: PMC6868921.
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    77. The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda. Antimicrob Agents Chemother. 2019 10; 63(10). Conrad MD, Nsobya SL, Rosenthal PJ. PMID: 31358588; PMCID: PMC6761569.
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    78. Artemisinin Resistance in Eastern India. Clin Infect Dis. 2019 09 13; 69(7):1153-1155. Rosenthal PJ. PMID: 30541018.
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    79. Antimalarial drug resistance in Africa: the calm before the storm? Lancet Infect Dis. 2019 10; 19(10):e338-e351. Conrad MD, Rosenthal PJ. PMID: 31375467.
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    80. Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention. Clin Pharmacol Ther. 2019 12; 106(6):1310-1318. Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT. PMID: 31173649; PMCID: PMC6851416.
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    81. A shorter course for anti-relapse therapy against vivax malaria. Lancet. 2019 09 14; 394(10202):898-900. Rosenthal PJ. PMID: 31327565.
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    82. Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand? Clin Infect Dis. 2019 07 02; 69(2):287-289. Guler JL, Rosenthal PJ. PMID: 30304408.
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    83. Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. Nat Commun. 2019 06 27; 10(1):2816. Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. PMID: 31249291; PMCID: PMC6597546.
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    84. Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial. PLoS Med. 2019 06; 16(6):e1002835. Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD, MORDOR Study Group. PMID: 31237871; PMCID: PMC6592520.
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    85. Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. PLoS One. 2019; 14(6):e0218318. Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL. PMID: 31220115; PMCID: PMC6586300.
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    86. Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. J Med Chem. 2019 07 11; 62(13):6137-6145. Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. PMID: 31177777; PMCID: PMC7104388.
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    87. Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda. PLoS One. 2019; 14(6):e0217262. Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A. PMID: 31166968; PMCID: PMC6550380.
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    88. Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States. Am J Trop Med Hyg. 2019 06; 100(6):1295-1296. Rosenthal PJ, Tan KR. PMID: 30927931; PMCID: PMC6553912.
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    89. Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. 2019 06 13; 62(11):5562-5578. Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ. PMID: 31062592.
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    90. Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation. Bioorg Chem. 2019 07; 88:102912. Rani A, Legac J, Rosenthal PJ, Kumar V. PMID: 30991190.
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    91. Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda. J Infect Dis. 2019 03 15; 219(7):1104-1111. Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B. PMID: 30383230; PMCID: PMC6420168.
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    92. Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children. J Infect Dis. 2019 03 15; 219(7):1112-1120. Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ. PMID: 30418593; PMCID: PMC7868963.
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    93. Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda. Antimicrob Agents Chemother. 2019 03; 63(3). Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ. PMID: 30559133; PMCID: PMC6395896.
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    94. Malaria: How Are We Doing and How Can We Do Better? Am J Trop Med Hyg. 2019 02; 100(2):239-241. Rosenthal PJ, John CC, Rabinovich NR. PMID: 30628572; PMCID: PMC6367613.
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    95. Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. Nat Commun. 2019 01 29; 10(1):480. Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J. PMID: 30696903; PMCID: PMC6351525.
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    96. Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. Antimicrob Agents Chemother. 2019 02; 63(2). Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. PMID: 30530597; PMCID: PMC6355581.
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    97. Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda. Clin Infect Dis. 2019 01 07; 68(2):313-320. Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG. PMID: 29868722; PMCID: PMC6321857.
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    98. Volume 100 of the American Journal of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2019 01; 100(1):3-4. Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW. PMID: 30652665; PMCID: PMC6335895.
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    99. Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria. Malar J. 2018 Dec 18; 17(1):476. Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G. PMID: 30563514; PMCID: PMC6299589.
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    100. Artemisinin Resistance Outside of Southeast Asia. Am J Trop Med Hyg. 2018 12; 99(6):1357-1359. Rosenthal PJ. PMID: 30426924; PMCID: PMC6283499.
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    101. Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS One. 2018; 13(9):e0204347. Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. PMID: 30235327; PMCID: PMC6147503.
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    102. Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One. 2018; 13(9):e0203229. Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ. PMID: 30222732; PMCID: PMC6141089.
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    103. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis. 2018 09 14; 67(7):1079-1088. Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT. PMID: 29547881; PMCID: PMC6137112.
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    104. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. PMID: 30138453; PMCID: PMC6107107.
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    105. Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis. 2018 07 02; 218(3):434-442. Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L. PMID: 29659945; PMCID: PMC6048984.
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    106. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6863-E6870. Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G. PMID: 29967165; PMCID: PMC6055138.
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    107. Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis. 2018 03 05; 217(6):964-972. Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM. PMID: 29272443; PMCID: PMC5853566.
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    108. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem. 2018 Apr 10; 149:69-78. Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. PMID: 29499488.
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    109. Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J. 2018 Feb 05; 17(1):67. Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. PMID: 29402282; PMCID: PMC5800031.
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    110. "The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health. Am J Trop Med Hyg. 2017 12; 97(6):1955-1957. Dunavan CP, Rosenthal PJ. PMID: 29187275; PMCID: PMC5805082.
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    111. Changing Antimalarial Drug Sensitivities in Uganda. Antimicrob Agents Chemother. 2017 12; 61(12). Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL, Rosenthal PJ, Cooper RA. PMID: 28923866; PMCID: PMC5700361.
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    112. Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2018 Jan 01; 143:150-156. Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V. PMID: 29174811.
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    113. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. J Infect Dis. 2017 11 15; 216(8):1008-1017. Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 28968782; PMCID: PMC5853776.
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    114. Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg. 2017 Nov; 97(5):1513-1523. Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C. PMID: 29016322; PMCID: PMC5817743.
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    115. Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda. Am J Trop Med Hyg. 2017 Nov; 97(5):1576-1580. Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ. PMID: 29016309; PMCID: PMC5817777.
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    116. Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Am J Trop Med Hyg. 2017 12; 97(6):1777-1781. Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. PMID: 29016335; PMCID: PMC5805042.
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    117. Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol. 2017 11; 55:281-287. Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. PMID: 28939159; PMCID: PMC5685907.
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    118. Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center. Am J Trop Med Hyg. 2017 09; 97(3):629-630. Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF. PMID: 28990909; PMCID: PMC5590616.
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    119. Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg. 2017 Sep; 97(3):753-757. Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ. PMID: 28990911; PMCID: PMC5590612.
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    120. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem. 2017 08 24; 60(16):6911-6923. Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. PMID: 28763614.
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    121. The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017 Aug 01; 65(3):486-494. Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal PJ. PMID: 28402391; PMCID: PMC5850314.
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    122. 4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation. Eur J Med Chem. 2017 Sep 29; 138:993-1001. Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V. PMID: 28756265.
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    123. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. Am J Trop Med Hyg. 2017 Sep; 97(3):696-701. O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM. PMID: 28722569; PMCID: PMC5590561.
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    124. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407. Blank BR, Gut J, Rosenthal PJ, Renslo AR. PMID: 28692297; PMCID: PMC5535261.
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    125. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. J Med Chem. 2017 07 13; 60(13):5889-5908. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J. PMID: 28635296.
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    126. Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Chem Biol Drug Des. 2017 Oct; 90(4):590-595. Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V. PMID: 28332319.
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    127. Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J. 2017 03 21; 16(1):125. Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ. PMID: 28327148; PMCID: PMC5361791.
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    128. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017 03 06; 8:14574. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. PMID: 28262680; PMCID: PMC5343452.
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    129. Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Mol Med. 2017 03; 9(3):385-394. Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. PMID: 28148555; PMCID: PMC5331205.
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    130. Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis. 2017 02 15; 215(4):631-635. Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 28039354; PMCID: PMC5853976.
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    131. Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J. 2017 02 10; 16(1):67. Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK. PMID: 28183299; PMCID: PMC5301436.
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    132. Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg. 2017 Jan 11; 96(1):5-6. Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. PMID: 28077738; PMCID: PMC5239708.
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    133. Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. Antimicrob Agents Chemother. 2017 01; 61(1). Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ. PMID: 27821443; PMCID: PMC5192118.
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    134. Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study. PLoS Med. 2016 Nov; 13(11):e1002167. Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Kamya MR, Dorsey G. PMID: 27824885; PMCID: PMC5100985.
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    135. The (International) American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2016 Nov 02; 95(5):980-982. Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. PMID: 27807294; PMCID: PMC5094245.
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    136. Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda. Open Forum Infect Dis. 2017; 4(1):ofw229. Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ. PMID: 28480232; PMCID: PMC5413987.
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    137. Communicable Diseases: A Global Perspective. Am J Trop Med Hyg. 2016 Oct 05; 95(4):974-975. Rosenthal PJ. PMID: 27708202.
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    139. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 10; 60(10):5817-27. Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. PMID: 27431220; PMCID: PMC5038320.
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    140. 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2017 Jan 05; 125:269-277. Singh A, Gut J, Rosenthal PJ, Kumar V. PMID: 27688182.
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    141. Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. Malar J. 2016 09 15; 15:470. Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B. PMID: 27628178; PMCID: PMC5024471.
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    142. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016 10 06; 11(19):2194-2204. Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. PMID: 27538856.
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    143. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 08; 60(8):4886-95. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. PMID: 27270277; PMCID: PMC4958189.
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    144. Azithromycin for Malaria? Am J Trop Med Hyg. 2016 07 06; 95(1):2-4. Rosenthal PJ. PMID: 27215296; PMCID: PMC4944689.
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    145. Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorg Med Chem. 2016 Apr 15; 24(8):1786-92. Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM. PMID: 26968650.
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    146. Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Malar J. 2015 Dec 30; 14:528. Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG. PMID: 26714465; PMCID: PMC4696244.
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    147. Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial. J Infect Dis. 2016 Apr 01; 213(7):1134-42. Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. PMID: 26597254; PMCID: PMC4836737.
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    148. Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites. ChemMedChem. 2015 Dec; 10(12):2080-9. Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MM. PMID: 26525306.
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    149. Artefenomel: a promising new antimalarial drug. Lancet Infect Dis. 2016 Jan; 16(1):6-8. Rosenthal PJ. PMID: 26448142.
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    150. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. PMID: 26617969; PMCID: PMC4645246.
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    151. The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children. Evid Based Med. 2015 Oct; 20(5):179. Rosenthal PJ. PMID: 26316645.
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    152. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):57-68. Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. PMID: 26259943; PMCID: PMC4574275.
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    153. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4438-47. Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B. PMID: 26216993; PMCID: PMC4538641.
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    154. Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. J Med Chem. 2015 Jul 09; 58(13):5344-54. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y. PMID: 26067904; PMCID: PMC4500456.
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    155. Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test. Am J Trop Med Hyg. 2015 Aug; 93(2):276-280. Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR. PMID: 26055736; PMCID: PMC4530747.
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    156. Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother. 2015 Aug; 59(8):5061-4. Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. PMID: 26033725; PMCID: PMC4505276.
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    157. Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2015 Aug; 59(8):4387-96. Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J, Rosenthal PJ, Sutherland C, Nosten F, Ouedraogo JB. PMID: 25918149; PMCID: PMC4505196.
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    158. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. BMC Med. 2015 Mar 31; 13:66. WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Brasseur P, Bukirwa H, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Desai M, Diap G, Djimde AA, Dorsey G, Doumbo OK, Espié E, Etard JF, Fanello CI, Faucher JF, Faye B, Flegg JA, Gaye O, Gething PW, González R, Grandesso F, Guerin PJ, Guthmann JP, Hamour S, Hasugian AR, Hay SI, Humphreys GS, Jullien V, Juma E, Kamya MR, Karema C, Kiechel JR, Kremsner PG, Krishna S, Lameyre V, Ibrahim LM, Lee SJ, Lell B, Mårtensson A, Massougbodji A, Menan H, Ménard D, Menéndez C, Meremikwu M, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Nikiema F, Nsanzabana C, Ntoumi F, Ogutu BR, Olliaro P, Osorio L, Ouédraogo JB, Penali LK, Pene M, Pinoges L, Piola P, Price RN, Roper C, Rosenthal PJ, Rwagacondo CE, Same-Ekobo A, Schramm B, Seck A, Sharma B, Sibley CH, Sinou V, Sirima SB, Smith JJ, Smithuis F, Somé FA, Sow D, Staedke SG, Stepniewska K, Swarthout TD, Sylla K, Talisuna AO, Tarning J, Taylor WR, Temu EA, Thwing JI, Tjitra E, Tine RC, Tinto H, Vaillant MT, Valecha N, Van den Broek I, White NJ, Yeka A, Zongo I. PMID: 25888957; PMCID: PMC4411752.
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    159. Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates. Eur J Med Chem. 2015 May 05; 95:230-9. Raj R, Saini A, Gut J, Rosenthal PJ, Kumar V. PMID: 25817773.
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    160. Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids. ChemMedChem. 2015 May; 10(5):883-90. Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R. PMID: 25784585.
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    161. Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme. Arch Biochem Biophys. 2015 May 01; 573:92-9. Marques AF, Gomes PS, Oliveira PL, Rosenthal PJ, Pascutti PG, Lima LM. PMID: 25791019.
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    162. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg. 2015 May; 92(5):903-12. Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G. PMID: 25778501; PMCID: PMC4426576.
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    163. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015; 59(6):3018-30. Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, Greenhouse B, Nsobya SL, Rosenthal PJ. PMID: 25753626; PMCID: PMC4432194.
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    164. The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots. Am J Trop Med Hyg. 2015 May; 92(5):922-5. Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B. PMID: 25758652; PMCID: PMC4426578.
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    165. N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity. Bioorg Med Chem. 2015 Apr 01; 23(7):1530-9. Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. PMID: 25725608.
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    166. Perspectives on Ebola. Am J Trop Med Hyg. 2015 Feb; 92(2):219-220. Rosenthal PJ, Bausch DG. PMID: 25582689; PMCID: PMC4347313.
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    167. Reply to Goyal et al. J Infect Dis. 2015 May 15; 211(10):1687. Hsiang MS, Greenhouse B, Rosenthal PJ. PMID: 25512627; PMCID: PMC4407763.
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    168. Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem. 2014 Dec 26; 57(24):10557-63. Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ. PMID: 25412465.
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    169. Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. Eur J Med Chem. 2015 Jan 27; 90:507-18. Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. PMID: 25486422.
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    170. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. PMID: 25493596; PMCID: PMC4487368.
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    171. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. PMID: 25314098; PMCID: PMC4420023.
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    172. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis. 2015 Mar 01; 211(5):680-8. Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. PMID: 25180240; PMCID: PMC4402372.
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    173. Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. PLoS One. 2014; 9(8):e105690. Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. PMID: 25144768; PMCID: PMC4140830.
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    174. Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine. PLoS One. 2014; 9(8):e103200. Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. PMID: 25133389; PMCID: PMC4136730.
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    175. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med. 2014 Aug; 11(8):e1001689. Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. PMID: 25093754; PMCID: PMC4122345.
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    176. β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation. Eur J Med Chem. 2014 Sep 12; 84:566-73. Gut J, Rosenthal PJ, Kumar V. PMID: 25062007; PMCID: PMC7115587.
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    177. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am J Trop Med Hyg. 2014 Oct; 91(4):833-843. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, Sibley CH. PMID: 25048375; PMCID: PMC4183414.
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    178. Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity. Eur J Med Chem. 2014 Sep 12; 84:425-32. Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. PMID: 25038484.
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    179. Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum. J Enzyme Inhib Med Chem. 2015 Apr; 30(2):299-307. Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H. PMID: 24964346.
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    180. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. J Med Chem. 2014 Jun 12; 57(11):4916-23. Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F. PMID: 24824551.
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    181. Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria. Clin Infect Dis. 2014 Aug 15; 59(4):509-16. Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G. PMID: 24825870.
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    182. Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg. 2014 Jul; 91(1):54-61. Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ. PMID: 24799371; PMCID: PMC4080569.
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    183. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014 Oct 15; 210(8):1167-9. Hsiang MS, Greenhouse B, Rosenthal PJ. PMID: 24795471.
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    184. Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity. Eur J Med Chem. 2014 Jun 10; 80:523-34. Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R. PMID: 24813880.
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    185. Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis. 2014 Aug 01; 59(3):446-53. Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G. PMID: 24759826; PMCID: PMC4155440.
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    186. Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):535-41. Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J. PMID: 24326597; PMCID: PMC3999287.
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    187. Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem. 2014 Apr 24; 57(8):3295-313. Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. PMID: 24673163.
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    188. Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2014 Jul; 58(7):3660-5. Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ. PMID: 24733476; PMCID: PMC4068591.
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    189. Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. PLoS One. 2014; 9(4):e93008. Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R, Rosenthal PJ, Pandey KC. PMID: 24699522; PMCID: PMC3974720.
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    190. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections. Malar J. 2014 Mar 17; 13:102. Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC. PMID: 24636676; PMCID: PMC4004158.
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    191. 7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. Chem Biol Drug Des. 2014 May; 83(5):622-9. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V. PMID: 24341638.
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    192. Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J. 2014 Mar 14; 13:95. Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL, Rosenthal PJ. PMID: 24629020; PMCID: PMC4004386.
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    193. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis. 2014 May; 58(10):1404-12. Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR. PMID: 24621953; PMCID: PMC4001293.
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    194. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Am J Trop Med Hyg. 2014 May; 90(5):846-51. Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM. PMID: 24615132; PMCID: PMC4015576.
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    195. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis. 2014 Aug 01; 210(3):344-53. Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ. PMID: 24610872; PMCID: PMC4110461.
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    196. Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett. 2014 Mar 01; 24(5):1274-9. Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA. PMID: 24507921.
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    197. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis. 2014 Jul 01; 210(1):154-7. Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. PMID: 24446524; PMCID: PMC4162000.
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    198. 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):756-9. Raj R, Gut J, Rosenthal PJ, Kumar V. PMID: 24424135.
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    199. Changes at our journal. Am J Trop Med Hyg. 2014 Jan; 90(1):1-2. Rosenthal PJ. PMID: 24402700; PMCID: PMC3886403.
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    200. Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Bioanalysis. 2014; 6(23):3081-9. Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. PMID: 25529877; PMCID: PMC4321809.
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    201. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett. 2014 Feb 13; 5(2):108-12. Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. PMID: 24900781; PMCID: PMC4027774.
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    202. Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation. Eur J Med Chem. 2014 Jan; 71:128-34. Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V. PMID: 24287561.
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    203. 4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. Chem Biol Drug Des. 2014 Feb; 83(2):191-7. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V. PMID: 24034147.
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    204. Novel anti-plasmodial hits identified by virtual screening of the ZINC database. J Comput Aided Mol Des. 2013 Oct; 27(10):859-71. Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC. PMID: 24158745.
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    205. Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. ACS Med Chem Lett. 2013 Dec 12; 4(12):1198-202. Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. PMID: 24900630; PMCID: PMC4027225.
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    206. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem. 2013 Oct 10; 56(19):7679-90. Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. PMID: 24020770.
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    207. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem. 2013 Nov; 69:872-80. Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F. PMID: 24125849.
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    208. Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents. Eur J Med Chem. 2013 Nov; 69:365-72. Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. PMID: 24077527.
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    209. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malar J. 2013 Sep 11; 12:317. Gong L, Parikh S, Rosenthal PJ, Greenhouse B. PMID: 24025776; PMCID: PMC3847285.
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    210. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 2013; 8(9):e73530. Prasad R, Kolla VK, Legac J, Singhal N, Navale R, Rosenthal PJ, Sijwali PS. PMID: 24023882; PMCID: PMC3759421.
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    211. The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol. 2013 Sep; 89(6):1025-38. Rosenthal PJ. PMID: 23899091; PMCID: PMC3792794.
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    212. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013 Dec; 96:347-52. Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H. PMID: 23863332.
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    213. An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. ChemMedChem. 2013 Sep; 8(9):1528-36. Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. PMID: 23853126.
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    214. Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorg Med Chem. 2013 Sep 01; 21(17):4904-13. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. PMID: 23896611.
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    215. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10; 12:234. Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR. PMID: 23841934; PMCID: PMC3726445.
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    216. An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. J Clin Virol. 2013 Sep; 58(1):276-8. Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C. PMID: 23827788; PMCID: PMC4036801.
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    217. Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites. Antimicrob Agents Chemother. 2013 Sep; 57(9):4245-4251. Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ. PMID: 23796921; PMCID: PMC3754360.
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    218. Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. Mol Inform. 2013 Jul; 32(7):659-70. Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F, Rosenthal PJ, Moreira R, Dos Santos DJ. PMID: 27481771.
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    219. Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. J Clin Microbiol. 2013 Aug; 51(8):2564-70. LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ. PMID: 23720790; PMCID: PMC3719660.
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    220. Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem. 2013 Jun 13; 56(11):4811-5. Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. PMID: 23701465.
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    221. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. ACS Med Chem Lett. 2013 Jul 11; 4(7):637-41. Njogu PM, Gut J, Rosenthal PJ, Chibale K. PMID: 24900723; PMCID: PMC4027494.
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    222. Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. ACS Med Chem Lett. 2013 Jul 11; 4(7):642-6. Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K. PMID: 24900724; PMCID: PMC4027233.
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    223. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul; 57(7):3131-6. Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. PMID: 23629719; PMCID: PMC3697387.
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    224. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 01; 21(13):3667-73. Marques AF, Esser D, Rosenthal PJ, Kassack MU, Lima LM. PMID: 23680445.
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    225. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation. Eur J Med Chem. 2013 Apr; 62:590-6. Raj R, Singh P, Singh P, Gut J, Rosenthal PJ, Kumar V. PMID: 23434528.
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    226. Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. Am J Trop Med Hyg. 2013 Apr; 88(4):744-6. Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G. PMID: 23358639; PMCID: PMC3617863.
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    227. Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. Mol Biochem Parasitol. 2013 Feb; 187(2):111-6. Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML, Rosenthal PJ, Juliano L, Carmona AK. PMID: 23354130.
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    228. N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads. J Med Chem. 2013 Jan 24; 56(2):556-67. Pérez BC, Teixeira C, Albuquerque IS, Gut J, Rosenthal PJ, Gomes JR, Prudêncio M, Gomes P. PMID: 23273038.
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    229. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012 Dec 28; 11:435. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. PMID: 23273022; PMCID: PMC3551700.
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    230. In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. Bioorg Med Chem Lett. 2013 Feb 01; 23(3):610-3. Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J, Rosenthal PJ, Prudêncio M, Gomes P. PMID: 23290049.
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    231. Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. PLoS One. 2012; 7(12):e52571. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. PMID: 23285095; PMCID: PMC3526588.
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    232. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. Am J Trop Med Hyg. 2013 Feb; 88(2):289-91. Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. PMID: 23249688; PMCID: PMC3583319.
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    233. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. PMID: 23234548; PMCID: PMC3574796.
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    234. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29; 367(22):2110-8. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. PMID: 23190222; PMCID: PMC3664297.
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    235. Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo. Malar J. 2012 Nov 21; 11:382. Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ. PMID: 23171238; PMCID: PMC3519527.
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    236. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):310-6. Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT. PMID: 22918158; PMCID: PMC3511816.
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    237. 1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues. ACS Med Chem Lett. 2012 Dec 13; 3(12):1029-33. Lu X, Altharawi A, Gut J, Rosenthal PJ, Long TE. PMID: 24936235; PMCID: PMC4056940.
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    238. Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. ChemMedChem. 2012 Sep; 7(9):1537-40. Pérez B, Teixeira C, Gut J, Rosenthal PJ, Gomes JR, Gomes P. PMID: 22753234.
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    239. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):5046-50. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. PMID: 22749280.
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    240. Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials. Eur J Med Chem. 2012 Aug; 54:887-99. Pérez BC, Teixeira C, Figueiras M, Gut J, Rosenthal PJ, Gomes JR, Gomes P. PMID: 22683112.
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    241. Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins. Malar J. 2012 May 07; 11:156. Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML. PMID: 22564457; PMCID: PMC3407703.
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    242. Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis. J Chem Inf Model. 2012 Mar 26; 52(3):696-710. Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA. PMID: 22332946.
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    243. Phosphonium lipocations as antiparasitic agents. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2976-9. Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ. PMID: 22414614; PMCID: PMC3321104.
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    244. Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood. 2012 Apr 19; 119(16):3808-14. Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B. PMID: 22327223; PMCID: PMC3335384.
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    245. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr; 54(7):1001-9. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. PMID: 22308272; PMCID: PMC3297647.
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    246. How do we best diagnose malaria in Africa? Am J Trop Med Hyg. 2012 Feb; 86(2):192-193. Rosenthal PJ. PMID: 22302846; PMCID: PMC3269265.
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    247. The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012; 7(7):699-708. Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J. PMID: 23293660; PMCID: PMC3535690.
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    248. Novel potent metallocenes against liver stage malaria. Antimicrob Agents Chemother. 2012 Mar; 56(3):1564-70. Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal PJ, Prudêncio M, Gomes P. PMID: 22155838; PMCID: PMC3294896.
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    249. Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):57-61. Singh P, Singh P, Kumar M, Gut J, Rosenthal PJ, Kumar K, Kumar V, Mahajan MP, Bisetty K. PMID: 22172698.
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    250. Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. Am J Trop Med Hyg. 2011 Nov; 85(5):793-804. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ. PMID: 22049029; PMCID: PMC3205621.
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    251. The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Trans R Soc Trop Med Hyg. 2012 Jan; 106(1):35-42. Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ. PMID: 22018600.
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    252. Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. Bioorg Med Chem. 2011 Dec 15; 19(24):7635-42. Glória PM, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. PMID: 22071522.
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    253. Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 2011 Oct 01; 204(7):1120-4. Baliraine FN, Rosenthal PJ. PMID: 21881128; PMCID: PMC3164433.
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    254. Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁. Bioorg Med Chem. 2011 Nov 01; 19(21):6302-8. Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC. PMID: 21958736.
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    255. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Nov; 55(11):5073-7. Nsanzabana C, Rosenthal PJ. PMID: 21876053; PMCID: PMC3194998.
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    256. Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola. Malar J. 2011 Aug 24; 10:248. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 21864379; PMCID: PMC3176256.
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    257. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Chemother. 2011 Oct; 55(10):4698-706. Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. PMID: 21807973; PMCID: PMC3186991.
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    258. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants. Parasitol Res. 2012 Jan; 110(1):109-17. Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E, Rosenthal PJ. PMID: 21739316.
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    259. Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Acta Trop. 2012 Mar; 121(3):196-201. Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 21756863; PMCID: PMC3439212.
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    260. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis. 2011 Jul 01; 204(1):19-26. Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. PMID: 21628654; PMCID: PMC3105040.
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    261. Lessons from sickle cell disease in the treatment and control of malaria. N Engl J Med. 2011 Jun 30; 364(26):2549-51. Rosenthal PJ. PMID: 21714653.
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    262. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11405-10. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L. PMID: 21709259; PMCID: PMC3136263.
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    263. Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. ChemMedChem. 2011 Sep 05; 6(9):1581-6. Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C, Rosenthal PJ, Schmuck C. PMID: 21678556.
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    264. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24; 10:144. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. PMID: 21609473; PMCID: PMC3121651.
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    265. Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. J Med Chem. 2011 May 26; 54(10):3637-49. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. PMID: 21500839; PMCID: PMC3104272.
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    266. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521; PMCID: PMC3086806.
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    267. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. J Chem Inf Model. 2011 Apr 25; 51(4):852-64. Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA. PMID: 21428453.
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    268. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar; 121(3):184-95. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 21420377; PMCID: PMC3156969.
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    269. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2055-8. Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. PMID: 21376591.
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    270. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. PMID: 21262276.
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    271. Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol. 2011 Apr 12; 134(3):717-24. Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. PMID: 21256952.
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    272. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011 Mar; 46(3):927-33. Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R. PMID: 21295887.
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    273. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. PMID: 21207937.
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    274. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. ChemMedChem. 2011 Jan 03; 6(1):141-52. Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S, Rosenthal PJ, Gut J, Morschhäuser J, Bringmann G, Schirmeister T. PMID: 21082722.
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    275. Falcipains and other cysteine proteases of malaria parasites. Adv Exp Med Biol. 2011; 712:30-48. Rosenthal PJ. PMID: 21660657.
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    276. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. J Acquir Immune Defic Syndr. 2011 Jan 01; 56(1):44-50. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. PMID: 21099693; PMCID: PMC3078046.
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    277. FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. Int J Parasitol. 2011 Mar; 41(3-4):363-72. Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR. PMID: 21168413.
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    278. Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents. Bioorg Med Chem Lett. 2011 Jan 15; 21(2):644-51. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J. PMID: 21195617.
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    279. Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. Malar J. 2010 Dec 08; 9:355. Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F. PMID: 21143867; PMCID: PMC3017535.
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    280. Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. Parasitol Res. 2011 May; 108(5):1211-7. Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. PMID: 21107862; PMCID: PMC3077741.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    281. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb; 55(2):615-22. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. PMID: 21078941; PMCID: PMC3028814.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    282. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010 Nov 11; 53(21):7864-8. Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. PMID: 20945914.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    283. Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Nov; 55(3):330-5. Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV. PMID: 20592617; PMCID: PMC3025136.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    284. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorg Med Chem. 2010 Dec 01; 18(23):8243-56. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. PMID: 21044845.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    285. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem. 2010 Nov 25; 53(22):8202-6. Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. PMID: 20979352.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    286. Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. PLoS One. 2010 Oct 19; 5(10):e13438. Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG. PMID: 20976051; PMCID: PMC2957410.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    287. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis. 2010 Oct 12; 4(10):e849. Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. PMID: 20967286; PMCID: PMC2953480.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    288. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. PMID: 20863855; PMCID: PMC3280821.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    289. Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series. J Med Chem. 2010 Aug 26; 53(16):6129-52. Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. PMID: 20672841.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    290. Bis-alkylamine quindolone derivatives as new antimalarial leads. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5634-7. Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J, Rosenthal PJ, Moreira R, Paulo A. PMID: 20801652.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    291. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS. 2010 Jul 31; 24(12):1945-52. Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED. PMID: 20543656; PMCID: PMC2909782.
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    292. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. PLoS One. 2010 Jul 30; 5(7):e11759. Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 20689585; PMCID: PMC2912768.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    293. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. J Inorg Biochem. 2010 Oct; 104(10):1079-83. Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. PMID: 20621360.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    294. Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Malar J. 2010 Jun 23; 9:177. Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G. PMID: 20573194; PMCID: PMC2903607.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    295. Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. Malar J. 2010 Jun 18; 9:174. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 20565881; PMCID: PMC2898790.
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    296. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. PMID: 20485428; PMCID: PMC2874979.
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    297. Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS One. 2010 Apr 19; 5(4):e10227. Sijwali PS, Rosenthal PJ. PMID: 20419102; PMCID: PMC2856681.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    298. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. Antimicrob Agents Chemother. 2010 May; 54(5):1949-54. Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ. PMID: 20231394; PMCID: PMC2863637.
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    299. Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem. 2010 Mar 11; 53(5):1951-63. Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T. PMID: 20131843.
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    300. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2234-7. Hans RH, Gut J, Rosenthal PJ, Chibale K. PMID: 20206517.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    301. Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda. Malar J. 2010 Jan 15; 9:19. Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B. PMID: 20074380; PMCID: PMC2817701.
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    302. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 2010 Mar; 54(3):1200-6. Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. PMID: 20065051; PMCID: PMC2825959.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCTClinical Trials
    303. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):942-4. Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. PMID: 20045640.
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    304. Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem. 2009 Dec 10; 52(23):7800-7. Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. PMID: 19799426; PMCID: PMC2788672.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    305. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 2009 Dec 01; 200(11):1650-7. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. PMID: 19905933; PMCID: PMC2782860.
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    306. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis. 2009 Dec 01; 49(11):1629-37. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. PMID: 19877969.
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    307. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J. 2009 Nov 14; 8:254. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D. PMID: 19912657; PMCID: PMC2781026.
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    308. Antimalarial activity of azadipeptide nitriles. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):252-5. Löser R, Gut J, Rosenthal PJ, Frizler M, Gütschow M, Andrews KT. PMID: 19913414; PMCID: PMC2818362.
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    309. Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Antimicrob Agents Chemother. 2010 Jan; 54(1):52-9. Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F. PMID: 19841149; PMCID: PMC2798532.
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    310. Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. PLoS One. 2009 Sep 30; 4(9):e7246. Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S. PMID: 19789650; PMCID: PMC2748715.
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    311. On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. J Med Chem. 2009 Sep 24; 52(18):5662-72. Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C. PMID: 19715342.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    312. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials. 2010 Jan; 31(1):62-70. Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J, Nonalcoholic Steatohepatitis Clinical Research Network Research Group. PMID: 19761871; PMCID: PMC2936451.
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    313. Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children. Malar J. 2009 Sep 15; 8:213. Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 19754955; PMCID: PMC2749863.
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    314. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. J Infect Dis. 2009 Aug 01; 200(3):430-8. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN. PMID: 19534596; PMCID: PMC3975590.
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    315. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009 Aug 01; 51(4):424-9. German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT. PMID: 19506482.
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    316. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ. 2009 Jul 21; 339:b2763. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO. PMID: 19622553; PMCID: PMC2714631.
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    317. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. PMID: 19620707; PMCID: PMC2757971.
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    318. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. PMID: 19648008; PMCID: PMC2745105.
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    319. Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. Malar J. 2009 Jun 29; 8:145. Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J, Rosenthal PJ. PMID: 19563665; PMCID: PMC2707379.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    320. Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. PLoS One. 2009 May 27; 4(5):e5694. Pandey KC, Barkan DT, Sali A, Rosenthal PJ. PMID: 19479029; PMCID: PMC2682653.
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    321. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3476-80. Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. PMID: 19467600.
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    322. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. Bioorg Med Chem Lett. 2009 Jun 15; 19(12):3229-32. Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. PMID: 19435664; PMCID: PMC2742655.
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    323. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One. 2009; 4(4):e5156. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. PMID: 19357776; PMCID: PMC2663817.
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    324. Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet. 2009 May 09; 373(9675):1623-31. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ. PMID: 19362361.
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    325. Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo. Am J Trop Med Hyg. 2009 Apr; 80(4):555-8. Mobula L, Lilley B, Tshefu AK, Rosenthal PJ. PMID: 19346374.
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    326. Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. J Ethnopharmacol. 2009 Jun 25; 123(3):483-8. Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. PMID: 19442463.
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    327. Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C J Biosci. 2009 Mar-Apr; 64(3-4):210-4. Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J, Rosenthal PJ, Lobstein A, Tsamo E. PMID: 19526714.
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    328. Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis. 2009 Mar 01; 199(5):758-65. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 19199542; PMCID: PMC2733854.
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    329. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem. 2009 Feb 12; 52(3):852-7. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. PMID: 19128015; PMCID: PMC2651692.
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    330. The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda. AIDS Res Hum Retroviruses. 2009 Jan; 25(1):65-71. Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H. PMID: 19182922; PMCID: PMC2858297.
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    331. Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules. 2008 Dec 23; 14(1):19-35. Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C. PMID: 19104483; PMCID: PMC6253875.
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    332. Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec; 21(6):668-72. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. PMID: 18978536; PMCID: PMC2732359.
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    333. Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis. 2008 Nov 15; 198(10):1554-7. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ. PMID: 18808336.
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    334. Human genetics and malaria: relevance for the design of clinical trials. J Infect Dis. 2008 Nov 01; 198(9):1255-7. Parikh S, Rosenthal PJ. PMID: 18752442.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    335. Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. Eur J Med Chem. 2009 Apr; 44(4):1457-62. Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J, Rosenthal PJ. PMID: 19036479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    336. Experimental malaria infection triggers early expansion of natural killer cells. Infect Immun. 2008 Dec; 76(12):5873-82. Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL. PMID: 18824529; PMCID: PMC2583561.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    337. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis. 2008 Aug 01; 198(3):393-400. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 18522503.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    338. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One. 2008 Jun 11; 3(6):e2390. Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H. PMID: 18545692; PMCID: PMC2405936.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    339. Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J. 2008 Jun 11; 7:106. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG. PMID: 18547415; PMCID: PMC2441629.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    340. Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J. 2008 Jun 11; 7:107. Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO. PMID: 18547416; PMCID: PMC2464601.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    341. HIV RNA suppression among HIV-infected Ugandan children with measles. J Acquir Immune Defic Syndr. 2008 Jun 01; 48(2):225-7. Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV. PMID: 18520684; PMCID: PMC3040680.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    342. Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4150-3. Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P. PMID: 18539459.
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    343. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One. 2008 May 21; 3(5):e2252. Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D. PMID: 18493601; PMCID: PMC2375113.
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    344. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4210-4. Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM. PMID: 18554905.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    345. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 2008 Jun; 24(6):279-84. Dahl EL, Rosenthal PJ. PMID: 18450512.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    346. Artesunate for the treatment of severe falciparum malaria. N Engl J Med. 2008 Apr 24; 358(17):1829-36. Rosenthal PJ. PMID: 18434652.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    347. Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2008 Jun; 52(6):2212-22. Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA. PMID: 18411325; PMCID: PMC2415780.
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    348. High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008 Apr 01; 46(7):985-91. Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G. PMID: 18444813.
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    349. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar; 56(3):374-7. Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J, Rosenthal PJ. PMID: 18310952.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    350. Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 09; 283(19):12870-6. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. PMID: 18308731; PMCID: PMC2442342.
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    351. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis. 2008 Feb 15; 197(4):510-8. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. PMID: 18240951.
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    352. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. Chem Pharm Bull (Tokyo). 2008 Feb; 56(2):222-6. Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E, Rosenthal PJ, Sewald N. PMID: 18239315.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    353. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1378-81. Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. PMID: 18207399.
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    354. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics. 2008 Jan; 121(1):e58-64. Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J. PMID: 18166545.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    355. HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. J Acquir Immune Defic Syndr. 2007 Dec 15; 46(5):624-30. Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G. PMID: 18043317.
      View in: PubMed   Mentions: 2  Translation:HumansCells
    356. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):485-8. Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. PMID: 18077165.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    357. Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. J Trop Pediatr. 2008 Feb; 54(1):6-13. Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H. PMID: 17984125.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    358. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis. 2007 Dec 01; 45(11):1453-61. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB. PMID: 17990228.
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    359. Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6434-8. Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K. PMID: 17949976.
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    360. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007 Oct 01; 21(15):2059-66. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. PMID: 17885296.
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    361. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007 Sep 06; 6:121. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. PMID: 17822535; PMCID: PMC2008207.
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    362. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother. 2007 Oct; 51(10):3485-90. Dahl EL, Rosenthal PJ. PMID: 17698630; PMCID: PMC2043295.
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    363. Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides. ChemMedChem. 2007 Aug; 2(8):1214-24. Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J, Rosenthal PJ, Schirmeister T. PMID: 17562535.
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    364. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrob Agents Chemother. 2007 Sep; 51(9):3096-103. Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 17591848; PMCID: PMC2043236.
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    365. Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. J Biol Chem. 2007 Aug 24; 282(34):24961-9. Subramanian S, Sijwali PS, Rosenthal PJ. PMID: 17565983.
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    366. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 2007 Aug; 51(8):3023-5. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. PMID: 17562798; PMCID: PMC1932488.
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    367. Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg. 2007 Jun; 76(6):1092-7. Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. PMID: 17556616.
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    368. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA. 2007 May 23; 297(20):2210-9. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. PMID: 17519410.
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    369. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials. 2007 May 18; 2(5):e20. Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. PMID: 17525792; PMCID: PMC1876597.
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    370. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
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    371. A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2. Protein Eng Des Sel. 2007 Apr; 20(4):171-7. Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ. PMID: 17430972.
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    372. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clin Infect Dis. 2007 Mar 15; 44(6):889-91. German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. PMID: 17304470.
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    373. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug; 82(2):197-203. Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. PMID: 17361129.
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    374. Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae). Chem Pharm Bull (Tokyo). 2007 Mar; 55(3):464-7. Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J, Rosenthal PJ, Donald Connolly J. PMID: 17329893.
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    375. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet. 2007 Feb 10; 369(9560):491-8. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. PMID: 17292769.
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    376. Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. Eur J Med Chem. 2007 Jun; 42(6):735-42. León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J, Rosenthal PJ, Domínguez JN. PMID: 17321641.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    377. The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Malar J. 2006 Dec 14; 5:122. Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G. PMID: 17169157; PMCID: PMC1716173.
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    378. Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog. 2006 Nov; 2(11):e117. Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ. PMID: 17083274; PMCID: PMC1630708.
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    379. Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg. 2006 Nov; 75(5):836-42. Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G. PMID: 17123974; PMCID: PMC1697796.
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    380. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. Bioorg Med Chem. 2007 Jan 01; 15(1):273-82. Chipeleme A, Gut J, Rosenthal PJ, Chibale K. PMID: 17052908.
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    381. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep; 50(9):3124-31. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ. PMID: 16940111; PMCID: PMC1563505.
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    382. Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Am J Trop Med Hyg. 2006 Sep; 75(3):375-80. Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 16968909.
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    383. False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. J Clin Microbiol. 2006 Aug; 44(8):3021-4. Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED. PMID: 16891532; PMCID: PMC1594619.
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    384. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794; PMCID: PMC1544199.
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    385. Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):96-106. Sijwali PS, Koo J, Singh N, Rosenthal PJ. PMID: 16890302.
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    386. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg. 2006 Jul; 75(1):162-5. Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. PMID: 16837725.
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    387. Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin. Antimicrob Agents Chemother. 2006 Jun; 50(6):2207-9. Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE, Rosenthal PJ. PMID: 16723585; PMCID: PMC1479139.
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    388. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Trop Med Int Health. 2006 Jun; 11(6):789-99. Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G. PMID: 16771999.
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    389. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials. 2006 May; 1(1):e7. Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG. PMID: 16871329; PMCID: PMC1488893.
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    390. Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. Bioorg Med Chem Lett. 2006 Aug 01; 16(15):4115-9. Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. PMID: 16697641.
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    391. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorg Med Chem. 2006 Aug 15; 14(16):5605-15. Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. PMID: 16690319.
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    392. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 2006 May; 50(5):1893-5. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. PMID: 16641472; PMCID: PMC1472234.
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    393. Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg. 2006 May; 74(5):758-61. Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. PMID: 16687676.
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    394. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15; 193(8):1160-3. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. PMID: 16544257.
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    395. Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem. 2006 Mar 09; 49(5):1576-84. Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M. PMID: 16509575.
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    396. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis. 2006 Apr 01; 193(7):978-86. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. PMID: 16518760.
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    397. CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006 Jan; 74(1):41-3. Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G. PMID: 16407344.
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    398. Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f. Phytochemistry. 2006 Feb; 67(3):302-6. Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J, Rosenthal PJ, Connolly JD. PMID: 16368120.
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    399. Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'. Exp Parasitol. 2006 Mar; 112(3):187-92. Singh N, Sijwali PS, Pandey KC, Rosenthal PJ. PMID: 16337629.
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    400. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis. 2006 Jan 01; 193(1):9-15. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. PMID: 16323126.
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    401. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Am J Trop Med Hyg. 2005 Nov; 73(5):826-32. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. PMID: 16282288.
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    402. Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Am J Trop Med Hyg. 2005 Aug; 73(2):256-62. Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G. PMID: 16103584.
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    403. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med. 2005 Jul; 2(7):e190. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. PMID: 16033307; PMCID: PMC1181876.
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    404. Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother. 2005 Jul; 49(7):2983-5. Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. PMID: 15980379; PMCID: PMC1168637.
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    405. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. PMID: 15964982; PMCID: PMC1166610.
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    406. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem. 2005 May 19; 48(10):3654-8. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. PMID: 15887974.
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    407. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005 May 02; 13(9):3249-61. Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. PMID: 15809160.
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    408. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg. 2005 May; 72(5):573-80. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. PMID: 15891132.
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    409. Synthesis and antimalarial activity of sulfonamide chalcone derivatives. Farmaco. 2005 Apr; 60(4):307-11. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. PMID: 15848205.
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    410. Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2005 Feb; 139(2):205-12. Dahl EL, Rosenthal PJ. PMID: 15664655.
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    411. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. PMID: 15582423.
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    412. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg. 2004 Dec; 71(6):758-63. Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ. PMID: 15642967.
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    413. Cysteine proteases of malaria parasites. Int J Parasitol. 2004 Dec; 34(13-14):1489-99. Rosenthal PJ. PMID: 15582526.
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    414. Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg. 2004 Dec; 71(6):750-3. Parikh S, Dorsey G, Rosenthal PJ. PMID: 15642965.
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    415. Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet. 2004 Nov 27-Dec 3; 364(9449):1950-7. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. PMID: 15567011.
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    416. Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors. Parasitol Res. 2004 Oct; 94(4):312-7. Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y. PMID: 15372231.
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    417. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2004 Sep; 48(9):3241-5. Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K. PMID: 15328079; PMCID: PMC514760.
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    418. Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. Bioorg Med Chem Lett. 2004 Aug 02; 14(15):3901-5. Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. PMID: 15225694.
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    419. Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. J Biol Chem. 2004 Aug 20; 279(34):35236-41. Singh A, Rosenthal PJ. PMID: 15192087.
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    420. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
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    421. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004 Jun; 3(6):509-20. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. PMID: 15173840.
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    422. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8721-6. Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ. PMID: 15166288; PMCID: PMC423262.
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    423. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis. 2004 Jun 15; 189(12):2220-6. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 15181569.
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    424. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health. 2004 May; 9(5):624-9. Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. PMID: 15117308.
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    425. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4384-9. Sijwali PS, Rosenthal PJ. PMID: 15070727; PMCID: PMC384756.
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    426. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J. 2004 Mar 01; 378(Pt 2):529-38. Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. PMID: 14629194; PMCID: PMC1223978.
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    427. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry. 2003 Dec; 64(7):1269-75. Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. PMID: 14599525.
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    428. Antimalarial activities of novel synthetic cysteine protease inhibitors. Antimicrob Agents Chemother. 2003 Dec; 47(12):3810-4. Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP, Rosenthal PJ. PMID: 14638488; PMCID: PMC296233.
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    429. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrob Agents Chemother. 2003 Dec; 47(12):3806-9. Locher CP, Ruben PC, Gut J, Rosenthal PJ. PMID: 14638487; PMCID: PMC296210.
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    430. Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J Biol Chem. 2004 Jan 30; 279(5):3484-91. Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ. PMID: 14625277.
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    431. Antimalarial drug discovery: old and new approaches. J Exp Biol. 2003 Nov; 206(Pt 21):3735-44. Rosenthal PJ. PMID: 14506208.
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    432. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 14505663.
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    433. Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. J Infect Dis. 2003 Oct 15; 188(8):1231-8. Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ. PMID: 14551894.
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    434. Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Am J Trop Med Hyg. 2003 Sep; 69(3):247-52. Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 14628939.
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    435. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg. 2003 Sep; 69(3):244-6. Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. PMID: 14628938.
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    436. Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines. Bioorg Med Chem. 2003 May 15; 11(10):2293-9. Batra S, Sabnis YA, Rosenthal PJ, Avery MA. PMID: 12713840.
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    437. Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. Protein Sci. 2003 Mar; 12(3):501-9. Sabnis YA, Desai PV, Rosenthal PJ, Avery MA. PMID: 12592020; PMCID: PMC2312452.
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    438. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2003 Feb; 68(2):127-32. Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. PMID: 12641399.
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    439. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg. 2003 Feb; 68(2):133-9. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. PMID: 12641400.
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    440. Structure-activity relationships for inhibition of cysteine protease activity and developme