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Kevan Shokat, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentCellular Molecular Pharmacology
Phone415-514-0472
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    Other Positions
    TitleHoward Hughes Investigator
    InstitutionUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids
    NIH/NCI U01CA199241Apr 14, 2016 - Mar 31, 2020
    Role: Co-Principal Investigator
    Drugging the Switch-II Pocket of K-Ras
    NIH/NCI R01CA190408Sep 12, 2014 - Aug 31, 2019
    Role: Principal Investigator
    A Chemical Map of T Cell Signaling
    NIH/NIAID R01AI044009Sep 1, 1998 - Aug 31, 2008
    Role: Principal Investigator
    A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse
    NIH/NIBIB R01EB001987May 1, 1996 - Mar 31, 2013
    Role: Principal Investigator
    ENGINEERING ORTHOGONAL PROTEIN KINASE AND NUCLEOTIDES
    NIH/NCI R01CA070331May 1, 1996 - May 14, 2003
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat K, Sibley LD. Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. J Med Chem. 2017 Sep 21. PMID: 28933846.
      View in: PubMed
    2. Morisot N, Novotny CJ, Shokat K, Ron D. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addict Biol. 2017 Jul 06. PMID: 28681511.
      View in: PubMed
    3. Dang CV, Reddy EP, Shokat K, Soucek L. Drugging the 'undruggable' cancer targets. Nat Rev Cancer. 2017 Aug; 17(8):502-508. PMID: 28643779.
      View in: PubMed
    4. Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J, Leenders F, Heuckmann JM, Wolf J, Diebold J, Pall G, Peifer M, Aerts M, Gevaert K, Zahedi RP, Buettner R, Shokat K, McDonald NQ, Kast SM, Gautschi O, Thomas RK, Sos ML. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Sci Transl Med. 2017 Jun 14; 9(394). PMID: 28615362.
      View in: PubMed
    5. Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat K, Wang L. Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nat Chem Biol. 2017 Aug; 13(8):842-844. PMID: 28604697.
      View in: PubMed
    6. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat K, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2017 Jun 01; 127(6):2438. PMID: 28569734.
      View in: PubMed
    7. Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat K, Nakamura K. Long-term oral kinetin does not protect against a-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017 Apr 20. PMID: 28434973.
      View in: PubMed
    8. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat K, Weiss WA. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 Mar 13; 31(3):424-435. PMID: 28292440.
      View in: PubMed
    9. Reed DE, Shokat K. INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Mol Cancer Res. 2017 Jun; 15(6):765-775. PMID: 28196852.
      View in: PubMed
    10. Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat K, Burlingame AL. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 Feb; 16(2):265-277. PMID: 27940637.
      View in: PubMed
    11. Uchida Y, Rutaganira FU, Jullie D, Shokat K, von Zastrow M. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Mol Pharmacol. 2017 Jan; 91(1):65-73. PMID: 27821547.
      View in: PubMed
    12. Lazarus MB, Levin RS, Shokat K. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cell Signal. 2017 Jan; 29:78-83. PMID: 27760376.
      View in: PubMed
    13. Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat K. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nat Chem Biol. 2016 Nov; 12(11):923-930. PMID: 27595329.
      View in: PubMed
    14. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. From Powerful Review Articles to Research Breakthroughs. Cell Chem Biol. 2016 Aug 18; 23(8):883-4. PMID: 27541190.
      View in: PubMed
    15. Jo A, Choi TG, Jo YH, Jyothi KR, Nguyen MN, Kim JH, Lim S, Shahid M, Akter S, Lee S, Lee KH, Kim W, Cho H, Lee J, Shokat K, Yoon KS, Kang I, Ha J, Kim SS. Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment. Antioxid Redox Signal. 2017 Jan 10; 26(2):70-83. PMID: 27357096.
      View in: PubMed
    16. Levin RS, Hertz NT, Burlingame AL, Shokat K, Mukherjee S, et al. Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33):E4776-83. PMID: 27482120; PMCID: PMC4995946 [Available on 02/16/17].
    17. Ostrem JM, Shokat K. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov. 2016 11; 15(11):771-785. PMID: 27469033.
      View in: PubMed
    18. Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, Shokat K, Bandyopadhyay S, Lord CJ, Ashworth A. Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Mol Cancer Ther. 2016 Jul; 15(7):1472-84. PMID: 27364904.
      View in: PubMed
    19. Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat K, Benes CH, Bardeesy N. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 Jul; 6(7):727-39. PMID: 27231123.
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    20. Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat K. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 2016 06 09; 534(7606):272-6. PMID: 27279227; PMCID: PMC4902179 [Available on 11/18/16].
    21. Tabaei SR, Guo F, Rutaganira FU, Vafaei S, Choong I, Shokat K, Glenn JS, Cho NJ. Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. Anal Chem. 2016 May 17; 88(10):5042-5. PMID: 27118725.
      View in: PubMed
    22. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat K, Gustafson WC, Huang J, Witte ON. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. PMID: 27050099; PMCID: PMC4829466 [Available on 04/11/17].
    23. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Our Advisors, Our Ambassadors, Our Editorial Board Members. Cell Chem Biol. 2016 Mar 17; 23(3):311-2. PMID: 26991096.
      View in: PubMed
    24. Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat K, Burke JE. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIß. J Med Chem. 2016 Mar 10; 59(5):1830-9. PMID: 26885694.
      View in: PubMed
    25. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Voices of Chemical Biology: Charting the Next Decade. Cell Chem Biol. 2016 Feb 18; 23(2):199. PMID: 26971865.
      View in: PubMed
    26. Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat K, Williams RL, Burke JE. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIß with Rab11. Protein Sci. 2016 Apr; 25(4):826-39. PMID: 26756197; PMCID: PMC4832280.
    27. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Cell Chemical Biology: Home of Exciting Chemical Biology. Cell Chem Biol. 2016 Jan 21; 23(1):1-2. PMID: 26933730.
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    28. Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat K, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016 Jan 01; 30(1):117-31. PMID: 26728557; PMCID: PMC4701974.
    29. Floor SN, Barkovich KJ, Condon KJ, Shokat K, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49. PMID: 26650549; PMCID: PMC4815421 [Available on 03/01/17].
    30. Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat K, Kuhlenschmidt MS, Sibley LD. Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture. Antimicrob Agents Chemother. 2015 Nov 09; 60(1):570-9. PMID: 26552986; PMCID: PMC4704151.
    31. Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat K, Oliver D, Halaszovich CR, Bustamante CD. Discovery and functional characterization of a neomorphic PTEN mutation. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13976-81. PMID: 26504226; PMCID: PMC4653168.
    32. Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat K, Brunet A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab. 2015 Nov 03; 22(5):907-21. PMID: 26456332; PMCID: PMC4635044 [Available on 11/03/16].
    33. Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat K, Weiss A. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 2015 Aug 24; 4. PMID: 26302204; PMCID: PMC4568592.
    34. Lazarus MB, Shokat K. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorg Med Chem. 2015 Sep 01; 23(17):5483-8. PMID: 26275681; PMCID: PMC4864979.
    35. Lipp JJ, Marvin MC, Shokat K, Guthrie C. SR protein kinases promote splicing of nonconsensus introns. Nat Struct Mol Biol. 2015 Aug; 22(8):611-7. PMID: 26167880.
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    36. Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat K, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Sci Signal. 2015 Jun 30; 8(383):ra65. PMID: 26126716.
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    37. Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat K, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19; 4. PMID: 25986605; PMCID: PMC4436593.
    38. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. PMID: 26029667; PMCID: PMC4429235.
    39. Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat K, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015 Apr 17; 11(4):800. PMID: 25888283; PMCID: PMC4422557.
    40. Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat K, Kannan N, Eyers PA. The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. Biochem J. 2015 Apr 01; 467(1):47-62. PMID: 25583260; PMCID: PMC4844368.
    41. Lazarus MB, Novotny CJ, Shokat K. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. ACS Chem Biol. 2015 Jan 16; 10(1):257-61. PMID: 25551253; PMCID: PMC4301081.
    42. Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat K. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 2014 Dec 22; 3. PMID: 25531068; PMCID: PMC4307180.
    43. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat K, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28. PMID: 25522764; PMCID: PMC4326592.
    44. Reed DE, Shokat K. Targeting osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18100-1. PMID: 25512494; PMCID: PMC4280583.
    45. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat K, McCormick F, Goga A, Bandyopadhyay S. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 Feb; 5(2):154-67. PMID: 25501949; PMCID: PMC4407699.
    46. Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat K, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 03; 84(5):968-82. PMID: 25456499; PMCID: PMC4407996.
    47. Crews C, Hertweck C, Shokat K, Suga H, Kostic M. Reflecting on the past and looking forward to the future of bridging chemistry and biology. Chem Biol. 2014 Sep 18; 21(9):1035-6. PMID: 25237850.
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    48. Chorba JS, Shokat K. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. PMID: 25210046; PMCID: PMC4200258.
    49. Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat K, Sieck GC. TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. J Appl Physiol (1985). 2014 Oct 15; 117(8):910-20. PMID: 25170066; PMCID: PMC4199990.
    50. Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat K, Weiss WA. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 08; 26(3):414-27. PMID: 25175806; PMCID: PMC4160413.
    51. Parker N, Falk H, Singh D, Fidaleo A, Smith B, Lopez MS, Shokat K, Wright WW. Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny. Biol Reprod. 2014 Oct; 91(4):92. PMID: 25165119; PMCID: PMC4435032.
    52. Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat K, Ibanez CF. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 2014 Aug 25; 3:e03245. PMID: 25161195; PMCID: PMC4139062.
    53. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat K, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. PMID: 25136127; PMCID: PMC4156735.
    54. Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat K. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep. 2014 Aug 21; 8(4):1037-48. PMID: 25127139; PMCID: PMC4294625.
    55. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat K, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. PMID: 24961373; PMCID: PMC4103324.
    56. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat K, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94. PMID: 24908390; PMCID: PMC4095875.
    57. Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat K, Williams RL. Structures of PI4KIIIß complexes show simultaneous recruitment of Rab11 and its effectors. Science. 2014 May 30; 344(6187):1035-8. PMID: 24876499; PMCID: PMC4046302.
    58. Riel-Mehan MM, Shokat K. A crosslinker based on a tethered electrophile for mapping kinase-substrate networks. Chem Biol. 2014 May 22; 21(5):585-90. PMID: 24746561; PMCID: PMC4627693.
    59. Lopez MS, Kliegman JI, Shokat K. The logic and design of analog-sensitive kinases and their small molecule inhibitors. Methods Enzymol. 2014; 548:189-213. PMID: 25399647.
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    60. Shokat K. Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. Methods Enzymol. 2014; 548:xi-xii. PMID: 25399648.
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    61. Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat K. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Rep. 2013 Dec 26; 5(6):1725-36. PMID: 24360963; PMCID: PMC4007695.
    62. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat K, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94. PMID: 24317039; PMCID: PMC3946925.
    63. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. PMID: 24300897; PMCID: PMC4117477.
    64. Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat K, Bollen A, Hann B, Phillips JJ. Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurg. 2014 Feb; 120(2):331-6. PMID: 24286145.
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    65. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat K. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28; 503(7477):548-51. PMID: 24256730; PMCID: PMC4274051.
    66. Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat K. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. 2013 Dec 04; 135(48):18153-9. PMID: 24171479; PMCID: PMC3938282.
    67. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat K, Weiss WA. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. PMID: 24135280; PMCID: PMC3819146.
    68. Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat K. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15; 154(4):737-47. PMID: 23953109; PMCID: PMC3950538.
    69. Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat K. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. 2013 Sep 20; 8(9):1931-8. PMID: 23841803; PMCID: PMC3938192.
    70. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat K, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93. PMID: 23803853; PMCID: PMC3718086.
    71. Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat K, Warren RS. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med. 2013 Aug; 2(4):496-506. PMID: 24156022; PMCID: PMC3799284.
    72. Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat K, Rubin SM, Fisher RP. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol Cell. 2013 Apr 25; 50(2):250-60. PMID: 23622515; PMCID: PMC3677717.
    73. Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat K, Warren RS. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 2014 Mar 20; 33(12):1590-600. PMID: 23542178; PMCID: PMC3982880.
    74. Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat K, Sibley LD. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem. 2013 Apr 11; 56(7):3068-77. PMID: 23470217; PMCID: PMC3625458.
    75. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat K, Ptácek LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 05; 17(2):291-302. PMID: 23395175; PMCID: PMC3597447.
    76. Crews C, Shokat K, Suga H, Kostic M. News from the Chemistry & Biology editorial team. Chem Biol. 2012 Nov 21; 19(11):1355. PMID: 23177188.
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    77. Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat K, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012 Dec; 15(12):1645-54. PMID: 23143520; PMCID: PMC3509236.
    78. Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat K, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol. 2012 Nov; 19(11):1108-15. PMID: 23064645; PMCID: PMC3746743.
    79. Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat K, Petrini JH, Fisher RP. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet. 2012 Aug; 8(8):e1002935. PMID: 22927831; PMCID: PMC3426557.
    80. Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat K, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet. 2012; 8(8):e1002822. PMID: 22876190; PMCID: PMC3410854.
    81. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat K, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. PMID: 22802621; PMCID: PMC3411950.
    82. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat K, Huang X, Sheppard D. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27. PMID: 22772469; PMCID: PMC3448403.
    83. Young ET, Zhang C, Shokat K, Parua PK, Braun KA. The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. J Biol Chem. 2012 Aug 17; 287(34):29021-34. PMID: 22761425; PMCID: PMC3436521.
    84. Cibrián Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat K, Selbach M, Abdelilah-Seyfried S. In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. PLoS One. 2012; 7(6):e40000. PMID: 22768194; PMCID: PMC3386912.
    85. Jang M, Kim Y, Won H, Lim S, K R J, Dashdorj A, Min YH, Kim SY, Shokat K, Ha J, Kim SS. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15; 72(16):4214-24. PMID: 22719067.
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    86. Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat K, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell. 2012 Jun 08; 46(5):691-704. PMID: 22681890; PMCID: PMC3380636.
    87. Dar AC, Das TK, Shokat K, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 06; 486(7401):80-4. PMID: 22678283; PMCID: PMC3703503.
    88. Sun Y, Miao Y, Yamane Y, Zhang C, Shokat K, Takematsu H, Kozutsumi Y, Drubin DG. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell. 2012 Jun; 23(12):2388-98. PMID: 22535525; PMCID: PMC3374756.
    89. St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat K, Geyer M, Fisher RP. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Mol Cell Biol. 2012 Jul; 32(13):2372-83. PMID: 22508988; PMCID: PMC3434489.
    90. Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat K, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1019-27. PMID: 22474407; PMCID: PMC3340028.
    91. Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat K, Wright WW. The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells. 2012 Apr; 30(4):732-40. PMID: 22232066; PMCID: PMC3894909.
    92. Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat K, Nicolaides T, Weiss WA. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov. 2012 May; 2(5):450-7. PMID: 22588882; PMCID: PMC3354705.
    93. Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat K, Jan LY, Jan YN. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012 Mar 22; 73(6):1127-42. PMID: 22445341; PMCID: PMC3333840.
    94. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat K, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. PMID: 22367541; PMCID: PMC3663483.
    95. Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat K. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Invest New Drugs. 2012 Dec; 30(6):2219-25. PMID: 22270257.
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    96. Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat K, Lens SM. Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol Cell Proteomics. 2012 May; 11(5):47-59. PMID: 22267324; PMCID: PMC3418839.
    97. Simon MD, Shokat K. A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods Enzymol. 2012; 512:57-69. PMID: 22910202.
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    98. Statsuk AV, Shokat K. Covalent cross-linking of kinases with their corresponding peptide substrates. Methods Mol Biol. 2012; 795:179-90. PMID: 21960223.
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    99. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat K, Brunet A. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011 Dec 23; 44(6):878-92. PMID: 22137581; PMCID: PMC3246132.
    100. Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat K, Gregan J. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle. 2011 Oct 15; 10(20):3527-32. PMID: 22030861; PMCID: PMC3266181.
    101. Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, Talmadge R, Harvey BK, Wyatt RM, Vernon-Pitts E, Zhang C, Shokat K, Fraser-Liggett C, Balice-Gordon RJ, Tessarollo L, Ward CW. Genetic deletion of trkB.T1 increases neuromuscular function. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C141-53. PMID: 21865582; PMCID: PMC3328911.
    102. Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R. The Cryptosporidium parvum kinome. BMC Genomics. 2011 Sep 30; 12:478. PMID: 21962082; PMCID: PMC3227725.
    103. Schoenborn JR, Tan YX, Zhang C, Shokat K, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal. 2011 Sep 13; 4(190):ra59. PMID: 21917715; PMCID: PMC4080844.
    104. Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat K. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15201-6. PMID: 21876130; PMCID: PMC3174577.
    105. Garske AL, Peters U, Cortesi AT, Perez JL, Shokat K. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15046-52. PMID: 21852571; PMCID: PMC3174669.
    106. Yoshii A, Murata Y, Kim J, Zhang C, Shokat K, Constantine-Paton M. TrkB and protein kinase M? regulate synaptic localization of PSD-95 in developing cortex. J Neurosci. 2011 Aug 17; 31(33):11894-904. PMID: 21849550; PMCID: PMC3158490.
    107. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat K, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 06; 9:48. PMID: 21729334; PMCID: PMC3158555.
    108. Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat K, Walter P. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 06; 9:47. PMID: 21729333; PMCID: PMC3149027.
    109. Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89. PMID: 21678117.
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    110. Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat K, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell. 2011 Jun 10; 42(5):624-36. PMID: 21658603; PMCID: PMC3119039.
    111. Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat K, Barford D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 2011 Apr 21; 472(7343):366-9. PMID: 21441910.
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    112. Crews C, Shokat K, Wohlleben W, Kostic M. Chemistry & Biology editors announce changes to the editorial team. Chem Biol. 2011 Feb 25; 18(2):141. PMID: 21338910.
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    113. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. PMID: 21199799; PMCID: PMC3077533.
    114. Dar AC, Shokat K. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annu Rev Biochem. 2011; 80:769-95. PMID: 21548788.
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    115. Salomon D, Zhang C, Shokat K, Sessa G. Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods Mol Biol. 2011; 779:185-97. PMID: 21837567.
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    116. Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat K, Schlapbach R, Colman-Lerner A, Nolan GP, Nesvizhskii AI, Peter M, Loewith R, von Mering C, Aebersold R. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal. 2010 Dec 21; 3(153):rs4. PMID: 21177495; PMCID: PMC3072779.
    117. Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat K, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. Rewiring of genetic networks in response to DNA damage. Science. 2010 Dec 03; 330(6009):1385-9. PMID: 21127252; PMCID: PMC3006187.
    118. Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat K, Mohr I. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes Dev. 2010 Dec 01; 24(23):2627-39. PMID: 21123650; PMCID: PMC2994037.
    119. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat K, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. PMID: 21062993; PMCID: PMC3001107.
    120. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat K, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec; 11(12):1085-92. PMID: 21037577; PMCID: PMC3711183.
    121. Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat K, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec; 12(12):1143-53. PMID: 21037565; PMCID: PMC3072784.
    122. Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat K, Messing RO. GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci. 2010 Oct 20; 30(42):13955-65. PMID: 20962217; PMCID: PMC2994917.
    123. Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR. Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Anal Chem. 2010 Nov 01; 82(21):8954-60. PMID: 20936785.
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    124. Tak E, Lee S, Lee J, Rashid MA, Kim YW, Park JH, Park WS, Shokat K, Ha J, Kim SS. Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. J Hepatol. 2011 Feb; 54(2):328-39. PMID: 21056497.
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    125. Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ. Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol. 2010 Sep; 17(9):1154-61. PMID: 20802488; PMCID: PMC4035229.
    126. Maciejowski J, George KA, Terret ME, Zhang C, Shokat K, Jallepalli PV. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 2010 Jul 12; 190(1):89-100. PMID: 20624902; PMCID: PMC2911671.
    127. Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat K. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Mol Biosyst. 2010 Aug; 6(8):1389-402. PMID: 20582381; PMCID: PMC2932704.
    128. Lourido S, Shuman J, Zhang C, Shokat K, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 2010 May 20; 465(7296):359-62. PMID: 20485436; PMCID: PMC2874977.
    129. Shokat K. A drug-drug interaction crystallizes a new entry point into the UPR. Mol Cell. 2010 Apr 23; 38(2):161-3. PMID: 20417596.
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    130. Sliedrecht T, Zhang C, Shokat K, Kops GJ. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One. 2010 Apr 22; 5(4):e10251. PMID: 20422024; PMCID: PMC2858645.
    131. Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat K, Williams RL. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science. 2010 Mar 26; 327(5973):1638-42. PMID: 20339072; PMCID: PMC2860105.
    132. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat K, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. PMID: 20338997; PMCID: PMC2865740.
    133. Poulikakos PI, Zhang C, Bollag G, Shokat K, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010 Mar 18; 464(7287):427-30. PMID: 20179705; PMCID: PMC3178447.
    134. Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat K, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010 Mar 16; 17(3):249-61. PMID: 20227039; PMCID: PMC2901095.
    135. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. PMID: 20194733; PMCID: PMC2841878.
    136. Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat K. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol. 2010 Mar 01; 2(1):15-36. PMID: 23836541; PMCID: PMC3894912.
    137. Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat K, Shaw JP, Williams RL. The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol. 2010 Mar; 6(3):244. PMID: 20154668.
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    138. Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat K. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol. 2010 Feb 26; 17(2):123-34. PMID: 20189103; PMCID: PMC2858875.
    139. An S, Kyoung M, Allen JJ, Shokat K, Benkovic SJ. Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem. 2010 Apr 09; 285(15):11093-9. PMID: 20157113; PMCID: PMC2856985.
    140. Knight ZA, Lin H, Shokat K. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer. 2010 02; 10(2):130-7. PMID: 20094047; PMCID: PMC2880454.
    141. Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat K, Shaw JP, Williams RL. The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol. 2010 Feb; 6(2):117-24. PMID: 20081827; PMCID: PMC2880452.
    142. Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat K, Moasser MM. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med. 2010 Jan 27; 2(16):16ra7. PMID: 20371474; PMCID: PMC3033659.
    143. Feldman ME, Shokat K. New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). Curr Top Microbiol Immunol. 2010; 347:241-62. PMID: 20549474.
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    144. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat K, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. PMID: 19996317; PMCID: PMC2836032.
    145. Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat K, Gygi SP, Hollingsworth NM. Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol Cell. 2009 Nov 13; 36(3):393-404. PMID: 19917248; PMCID: PMC2788773.
    146. Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat K, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science. 2009 Oct 09; 326(5950):294-8. PMID: 19815777; PMCID: PMC2865998.
    147. Carlson HK, Plate L, Price MS, Allen JJ, Shokat K, Marletta MA. Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Anal Biochem. 2010 Feb 15; 397(2):139-43. PMID: 19819215; PMCID: PMC2812668.
    148. Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat K, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18351-6. PMID: 19805051; PMCID: PMC2757399.
    149. Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol. 2009 Oct; 29(20):5455-64. PMID: 19667075; PMCID: PMC2756882.
    150. Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat K, Hahn S. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol. 2009 Sep; 29(17):4852-63. PMID: 19581288; PMCID: PMC2725703.
    151. de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ. PIKfyve regulation of endosome-linked pathways. Traffic. 2009 Jul; 10(7):883-93. PMID: 19582903; PMCID: PMC2723830.
    152. Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat K, Burlingame AL, Krogan NJ. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009 Jun 16; 7(6):e1000134. PMID: 19547744; PMCID: PMC2691599.
    153. Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat K. Inhibitor hijacking of Akt activation. Nat Chem Biol. 2009 Jul; 5(7):484-93. PMID: 19465931; PMCID: PMC2783590.
    154. Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat K, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009 May 05; 7(5):e1000111. PMID: 19468302; PMCID: PMC2680336.
    155. Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat K. Tuning the activation threshold of a kinase network by nested feedback loops. Science. 2009 Apr 24; 324(5926):509-12. PMID: 19390045; PMCID: PMC2880456.
    156. Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat K, Sessa G. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. J Biol Chem. 2009 May 29; 284(22):15289-98. PMID: 19332544; PMCID: PMC2685709.
    157. Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat K, Schwer B, Leatherwood JK, Fisher RP. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Mol Cell. 2009 Mar 27; 33(6):738-51. PMID: 19328067; PMCID: PMC2693121.
    158. Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat K, Burger JA. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28; 113(22):5549-57. PMID: 19318683; PMCID: PMC4580965.
    159. Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, Hann B, Blair J, Shokat K, Welm AL, Moasser MM. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clin Cancer Res. 2009 Apr 01; 15(7):2311-22. PMID: 19318475; PMCID: PMC3023342.
    160. Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat K, Krogan NJ. Functional organization of the S. cerevisiae phosphorylation network. Cell. 2009 Mar 06; 136(5):952-63. PMID: 19269370; PMCID: PMC2856666.
    161. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat K. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38. PMID: 19209957; PMCID: PMC2637922.
    162. Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat K, Walther TC, Krogan NJ, Koller D. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics. 2009 Jun; 8(6):1361-81. PMID: 19176519; PMCID: PMC2690481.
    163. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat K, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. PMID: 19176518; PMCID: PMC2793677.
    164. Miller AL, Zhang C, Shokat K, Lowell CA. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. PMID: 19124742; PMCID: PMC3248399.
    165. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat K, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. PMID: 19147570; PMCID: PMC2737189.
    166. Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat K, Krystal G. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 2009 Mar 26; 113(13):2945-54. PMID: 19139077; PMCID: PMC2662641.
    167. Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat K, Blackburn EH. Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 2009 Jan 09; 136(1):50-61. PMID: 19135888; PMCID: PMC2642970.
    168. Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat K. Tuning a three-component reaction for trapping kinase substrate complexes. J Am Chem Soc. 2008 Dec 24; 130(51):17568-74. PMID: 19053485; PMCID: PMC2863028.
    169. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat K, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 05; 457(7230):687-93. PMID: 19079236; PMCID: PMC2846394.
    170. Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat K, Hille B, Babcock DF, McKnight GS. Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20740-5. PMID: 19074277; PMCID: PMC2634883.
    171. Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat K, Fisher RP. Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Mol Cell. 2008 Dec 05; 32(5):662-72. PMID: 19061641; PMCID: PMC2643088.
    172. Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B. Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci. 2008 Dec 15; 121(Pt 24):4124-33. PMID: 19033389.
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    173. Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat K, Mody I, Messing RO. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci. 2008 Nov 12; 28(46):11890-9. PMID: 19005054; PMCID: PMC2688726.
    174. Kang J, Yang M, Li B, Qi W, Zhang C, Shokat K, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell. 2008 Nov 07; 32(3):394-405. PMID: 18995837; PMCID: PMC2644263.
    175. Shirra MK, McCartney RR, Zhang C, Shokat K, Schmidt MC, Arndt KM. A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem. 2008 Dec 19; 283(51):35889-98. PMID: 18955495; PMCID: PMC2602918.
    176. Dar AC, Lopez MS, Shokat K. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20; 15(10):1015-22. PMID: 18940662; PMCID: PMC2702663.
    177. Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat K, Montaner S. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Res. 2008 Oct 15; 68(20):8361-8. PMID: 18922908; PMCID: PMC2645787.
    178. Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat K, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov; 4(11):691-9. PMID: 18849971; PMCID: PMC2880455.
    179. Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat K, McCaffery JM, Luca FC. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell. 2008 Dec; 19(12):5559-78. PMID: 18843045; PMCID: PMC2592669.
    180. Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat K, Stokoe D. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J. 2008 Oct 01; 415(1):97-110. PMID: 18498248; PMCID: PMC3079392.
    181. Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat K, Vanhaesebroeck B, Marshall AJ. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol. 2008 Oct; 122(4):811-819.e2. PMID: 19014771.
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    182. Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat K, McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008 Oct 01; 68(19):8127-36. PMID: 18829572.
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    183. Bateman RL, Rauh D, Tavshanjian B, Shokat K. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. J Biol Chem. 2008 Dec 19; 283(51):35756-62. PMID: 18826943; PMCID: PMC2602912.
    184. Kim JS, Lilley BN, Zhang C, Shokat K, Sanes JR, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Dev. 2008 Sep 22; 3:23. PMID: 18808695; PMCID: PMC2564922.
    185. Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat K, Luger K. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol. 2008 Oct; 15(10):1122-4. PMID: 18794842; PMCID: PMC2648974.
    186. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat K, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2008 Sep; 118(9):3038-50. PMID: 18704194; PMCID: PMC2515380.
    187. Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat K. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 2008 Aug 12; 14(2):180-92. PMID: 18691552; PMCID: PMC2720137.
    188. Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat K, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. Eur J Neurosci. 2008 Sep; 28(5):997-1002. PMID: 18671735; PMCID: PMC2825165.
    189. Wang J, Knight ZA, Fiedler D, Williams O, Shokat K, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. PMID: 18653476; PMCID: PMC2536874.
    190. Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat K, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol. 2008 Aug; 4(8):498-506. PMID: 18622389.
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    191. Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat K, Gorospe M. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev. 2008 Jul 01; 22(13):1804-15. PMID: 18593881; PMCID: PMC2492667.
    192. Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat K, Fisher RP, Pommier Y. Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. J Mol Biol. 2008 Sep 05; 381(3):540-9. PMID: 18588899; PMCID: PMC2754794.
    193. Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat K, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 2008 Sep; 22(9):1698-706. PMID: 18548104.
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    194. Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat K, Fisher AG, Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7797-802. PMID: 18509048; PMCID: PMC2409380.
    195. Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res. 2008 Jul 01; 314(11-12):2299-312. PMID: 18514190; PMCID: PMC2531073.
    196. Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat K, Haas-Kogan D, Stokoe D. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr; 7(4):841-50. PMID: 18413797.
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    197. Levin SE, Zhang C, Kadlecek TA, Shokat K, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem. 2008 May 30; 283(22):15419-30. PMID: 18378687; PMCID: PMC2397475.
    198. Wan L, Niu H, Futcher B, Zhang C, Shokat K, Boulton SJ, Hollingsworth NM. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev. 2008 Feb 01; 22(3):386-97. PMID: 18245450; PMCID: PMC2216697.
    199. Blethrow JD, Glavy JS, Morgan DO, Shokat K. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1442-7. PMID: 18234856; PMCID: PMC2234163.
    200. Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry. 2008 Feb 12; 47(6):1599-607. PMID: 18205404.
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    201. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat K, Balla T. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell. 2008 Feb; 19(2):711-21. PMID: 18077555; PMCID: PMC2230591.
    202. Weiss WA, Taylor SS, Shokat K. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat Chem Biol. 2007 Dec; 3(12):739-44. PMID: 18007642; PMCID: PMC2924165.
    203. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat K, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 Nov 09; 318(5852):944-9. PMID: 17991856; PMCID: PMC3670588.
    204. Rubenstein EM, McCartney RR, Zhang C, Shokat K, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem. 2008 Jan 04; 283(1):222-30. PMID: 17991748; PMCID: PMC3244878.
    205. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat K. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. PMID: 18022565; PMCID: PMC2215327.
    206. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat K, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9. PMID: 17911242; PMCID: PMC1999396.
    207. Das M, Jiang F, Sluss HK, Zhang C, Shokat K, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15759-64. PMID: 17893331; PMCID: PMC2000443.
    208. Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat K, Messing RO. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem. 2007 Nov 09; 282(45):33052-63. PMID: 17875639.
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    209. Knight ZA, Garrison JL, Chan K, King DS, Shokat K. A remodelled protease that cleaves phosphotyrosine substrates. J Am Chem Soc. 2007 Sep 26; 129(38):11672-3. PMID: 17803306; PMCID: PMC2932698.
    210. Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat K, Weiss WA. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007 Sep 01; 67(17):7960-5. PMID: 17804702; PMCID: PMC2597547.
    211. Bateman R, Rauh D, Shokat K. Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Org Biomol Chem. 2007 Oct 21; 5(20):3363-7. PMID: 17912391; PMCID: PMC2932697.
    212. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat K. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. PMID: 17486086; PMCID: PMC2932705.
    213. Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat K, Thomas G. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe. 2007 Apr 19; 1(2):121-33. PMID: 18005690.
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    214. Knight ZA, Shokat K. Chemically targeting the PI3K family. Biochem Soc Trans. 2007 Apr; 35(Pt 2):245-9. PMID: 17371250.
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    215. Kanin EI, Kipp RT, Kung C, Slattery M, Viale A, Hahn S, Shokat K, Ansari AZ. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5812-7. PMID: 17392431; PMCID: PMC1851574.
    216. Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat K, Jallepalli PV, Fisher RP. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell. 2007 Mar 23; 25(6):839-50. PMID: 17386261; PMCID: PMC1858677.
    217. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat K. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 2007 Mar 09; 128(5):1003-12. PMID: 17350582; PMCID: PMC2932701.
    218. Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat K, Fisher RP, Jallepalli PV. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4383-8. PMID: 17360533; PMCID: PMC1838611.
    219. Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat K. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr; 3(4):229-38. PMID: 17334377.
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    220. Knight ZA, Shokat K. Chemical genetics: where genetics and pharmacology meet. Cell. 2007 Feb 09; 128(3):425-30. PMID: 17289560.
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    221. Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat K, Moasser MM. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature. 2007 Jan 25; 445(7126):437-41. PMID: 17206155; PMCID: PMC3025857.
    222. Knight ZA, Feldman ME, Balla A, Balla T, Shokat K. A membrane capture assay for lipid kinase activity. Nat Protoc. 2007; 2(10):2459-66. PMID: 17947987; PMCID: PMC2919233.
    223. Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat K. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc. 2007; 2(11):2996-3000. PMID: 18007635; PMCID: PMC2957860.
    224. Simon MD, Feldman ME, Rauh D, Maris AE, Wemmer DE, Shokat K. Structure and properties of a re-engineered homeodomain protein-DNA interface. ACS Chem Biol. 2006 Dec 15; 1(12):755-60. PMID: 17240973.
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    225. Wan L, Zhang C, Shokat K, Hollingsworth NM. Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. 2006 Dec; 174(4):1767-74. PMID: 17057233; PMCID: PMC1698632.
    226. Tóth B, Balla A, Ma H, Knight ZA, Shokat K, Balla T. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006 Nov 24; 281(47):36369-77. PMID: 17003043.
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    227. Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat K, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell. 2006 Sep 15; 23(6):899-911. PMID: 16973441.
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    228. Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat K, Bourne HR. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31; 174(3):437-45. PMID: 16864657; PMCID: PMC2064239.
    229. Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman MA, Shokat K, Rietz S, Parker J, Mundy J. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J. 2006 Aug; 47(4):532-46. PMID: 16813576.
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    230. Wei F, Wang GD, Zhang C, Shokat K, Wang H, Tsien JZ, Liauw J, Zhuo M. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Mol Pain. 2006 Jun 15; 2:21. PMID: 16776832; PMCID: PMC1513196.
    231. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat K, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. PMID: 16697955; PMCID: PMC2925230.
    232. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat K. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19; 125(4):733-47. PMID: 16647110; PMCID: PMC2946820.
    233. Allen JJ, Shokat K. Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. ACS Chem Biol. 2006 Apr 25; 1(3):139-40. PMID: 17163659.
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    234. Sturgeon CM, Knight ZA, Shokat K, Roberge M. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr; 5(4):885-92. PMID: 16648558.
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    235. Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat K. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr; 13(4):399-407. PMID: 16632252; PMCID: PMC2932700.
    236. Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat K, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell. 2006 Mar 03; 21(5):701-10. PMID: 16507367.
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    237. Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat K, Fisher RP. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle. 2006 Mar; 5(5):546-54. PMID: 16552187.
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    238. Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO. Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett. 2006 Jan 09; 580(1):179-83. PMID: 16364312.
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    239. Dephoure N, Howson RW, Blethrow JD, Shokat K, O'Shea EK. Combining chemical genetics and proteomics to identify protein kinase substrates. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):17940-5. PMID: 16330754; PMCID: PMC1306798.
    240. Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat K, Fisher RP. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan; 13(1):55-62. PMID: 16327805.
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    241. Pinsky BA, Kung C, Shokat K, Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat Cell Biol. 2006 Jan; 8(1):78-83. PMID: 16327780.
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    242. Kenski DM, Zhang C, von Zastrow M, Shokat K. Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem. 2005 Oct 14; 280(41):35051-61. PMID: 16081410.
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    243. D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat K, Amon A. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell. 2005 Jul 22; 19(2):223-34. PMID: 16039591.
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    244. Knight ZA, Shokat K. Features of selective kinase inhibitors. Chem Biol. 2005 Jun; 12(6):621-37. PMID: 15975507.
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    245. Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat K. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat Methods. 2005 Jun; 2(6):435-41. PMID: 15908922.
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    246. Cohen MS, Zhang C, Shokat K, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005 May 27; 308(5726):1318-21. PMID: 15919995; PMCID: PMC3641834.
    247. Shokat K. Chemicals call bacteria, and a new membrane protein machine answers. Cell. 2005 Apr 22; 121(2):163-6. PMID: 15851024.
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    248. Allen JJ, Lazerwith SE, Shokat K. Bio-orthogonal affinity purification of direct kinase substrates. J Am Chem Soc. 2005 Apr 20; 127(15):5288-9. PMID: 15826144; PMCID: PMC2943827.
    249. Alaimo PJ, Knight ZA, Shokat K. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg Med Chem. 2005 Apr 15; 13(8):2825-36. PMID: 15781393.
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    250. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat K, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21. PMID: 15820690.
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    251. Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat K, Adams CL. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May; 3(5):e128. PMID: 15799708; PMCID: PMC1073692.
    252. Muratani M, Kung C, Shokat K, Tansey WP. The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell. 2005 Mar 25; 120(6):887-99. PMID: 15797387.
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    253. Kung C, Shokat K. Small-molecule kinase-inhibitor target assessment. Chembiochem. 2005 Mar; 6(3):523-6. PMID: 15696508.
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    254. Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat K. Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3587-92. PMID: 15738404; PMCID: PMC552777.
    255. Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol. 2005 Jan 26; 15(2):160-5. PMID: 15668173.
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    256. Wong S, McLaughlin J, Cheng D, Zhang C, Shokat K, Witte ON. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17456-61. PMID: 15505216; PMCID: PMC524218.
    257. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat K. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 01; 12(17):4749-59. PMID: 15358300.
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    258. Maly DJ, Allen JA, Shokat K. A mechanism-based cross-linker for the identification of kinase-substrate pairs. J Am Chem Soc. 2004 Aug 04; 126(30):9160-1. PMID: 15281787.
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    259. Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat K, Butcher EC, Berg EL. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev Technol. 2004 Aug; 2(4):431-41. PMID: 15357924.
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    260. Simon MD, Sato K, Weiss GA, Shokat K. A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Res. 2004; 32(12):3623-31. PMID: 15247345; PMCID: PMC484177.
    261. Simon MD, Shokat K. Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. J Am Chem Soc. 2004 Jul 07; 126(26):8078-9. PMID: 15225024.
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    262. Sato K, Simon MD, Levin AM, Shokat K, Weiss GA. Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chem Biol. 2004 Jul; 11(7):1017-23. PMID: 15271360.
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    263. Blethrow J, Zhang C, Shokat K, Weiss EL. Design and use of analog-sensitive protein kinases. Curr Protoc Mol Biol. 2004 May; Chapter 18:Unit 18.11. PMID: 18265343.
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    264. Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat K, Goldenring JR, Shah K, Gillespie PG, Mercer JA. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1868-73. PMID: 14766983; PMCID: PMC357019.
    265. Liu Y, Kung C, Fishburn J, Ansari AZ, Shokat K, Hahn S. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol. 2004 Feb; 24(4):1721-35. PMID: 14749387; PMCID: PMC344185.
    266. Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat K, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett. 2004 Jan 02; 556(1-3):26-34. PMID: 14706820.
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    267. Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat K, Weiss WA. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res. 2003 Dec 15; 63(24):8930-8. PMID: 14695210.
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    268. Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol Biol Cell. 2004 Jan; 15(1):11-23. PMID: 14595109; PMCID: PMC307523.
    269. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat K, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. PMID: 14574415.
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    270. Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. PMID: 14564015.
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    271. Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat K, Wendland B, McDonald KL, McCaffery JM, Drubin DG. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol. 2003 Sep 01; 162(5):765-72. PMID: 12952930; PMCID: PMC2172809.
    272. Sreenivasan A, Bishop AC, Shokat K, Kellogg DR. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol Cell Biol. 2003 Sep; 23(17):6327-37. PMID: 12917352; PMCID: PMC180931.
    273. Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat K. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol. 2003 Sep; 21(9):1047-54. PMID: 12923550.
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    274. Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A. Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development. J Immunol. 2003 Jul 15; 171(2):519-23. PMID: 12847211.
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    275. Ulrich SM, Kenski DM, Shokat K. Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry. 2003 Jul 08; 42(26):7915-21. PMID: 12834343.
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    276. Benjamin KR, Zhang C, Shokat K, Herskowitz I. Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev. 2003 Jun 15; 17(12):1524-39. PMID: 12783856; PMCID: PMC196082.
    277. Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat K, Tsien JZ. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4287-92. PMID: 12646704; PMCID: PMC153085.
    278. Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat K, Weber MJ. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem. 2003 Apr 25; 278(17):14926-35. PMID: 12594221.
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    279. Abeliovich H, Zhang C, Dunn WA, Shokat K, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell. 2003 Feb; 14(2):477-90. PMID: 12589048; PMCID: PMC149986.
    280. Shah K, Shokat K. A chemical genetic approach for the identification of direct substrates of protein kinases. Methods Mol Biol. 2003; 233:253-71. PMID: 12840513.
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    281. Ulrich SM, Sallee NA, Shokat K. Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3223-7. PMID: 12372539.
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    282. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat K. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc. 2002 Oct 16; 124(41):12118-28. PMID: 12371851.
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    283. Buzko O, Shokat K. A kinase sequence database: sequence alignments and family assignment. Bioinformatics. 2002 Sep; 18(9):1274-5. PMID: 12217924.
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    284. Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol. 2002 Sep 02; 158(5):885-900. PMID: 12196508; PMCID: PMC2173146.
    285. Fan QW, Zhang C, Shokat K, Weiss WA. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Curr Biol. 2002 Aug 20; 12(16):1386-94. PMID: 12194819.
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    286. Shokat K, Velleca M. Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discov Today. 2002 Aug 15; 7(16):872-9. PMID: 12546954.
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    287. Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat K, McKnight GS. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. J Biol Chem. 2002 Aug 09; 277(32):28916-22. PMID: 12034735.
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    288. Specht KM, Shokat K. The emerging power of chemical genetics. Curr Opin Cell Biol. 2002 Apr; 14(2):155-9. PMID: 11891113.
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    289. Holt JR, Gillespie SK, Provance DW, Shah K, Shokat K, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 2002 Feb 08; 108(3):371-81. PMID: 11853671.
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    290. Buzko OV, Bishop AC, Shokat K. Modified AutoDock for accurate docking of protein kinase inhibitors. J Comput Aided Mol Des. 2002 Feb; 16(2):113-27. PMID: 12188021.
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    291. Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat K. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol. 2002 Jan; 9(1):25-33. PMID: 11841936.
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    292. Ulrich S, Shokat K. Green fluorescent protein-based protein kinase biosensor substrates. Methods Mol Biol. 2002; 183:275-85. PMID: 12136762.
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    293. Shah K, Shokat K. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem Biol. 2002 Jan; 9(1):35-47. PMID: 11841937.
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    294. Carroll AS, Bishop AC, DeRisi JL, Shokat K, O'Shea EK. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12578-83. PMID: 11675494; PMCID: PMC60096.
    295. Alaimo PJ, Shogren-Knaak MA, Shokat K. Chemical genetic approaches for the elucidation of signaling pathways. Curr Opin Chem Biol. 2001 Aug; 5(4):360-7. PMID: 11470597.
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    296. Schauder S, Shokat K, Surette MG, Bassler BL. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol. 2001 Jul; 41(2):463-76. PMID: 11489131.
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    297. Bishop AC, Buzko O, Shokat K. Magic bullets for protein kinases. Trends Cell Biol. 2001 Apr; 11(4):167-72. PMID: 11306297.
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    298. Habelhah H, Shah K, Huang L, Burlingame AL, Shokat K, Ronai Z. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. J Biol Chem. 2001 May 25; 276(21):18090-5. PMID: 11259409.
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    299. Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat K, Hentze MW, Ronai Z. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol. 2001 Mar; 3(3):325-30. PMID: 11231586.
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    300. Ting AY, Witte K, Shah K, Kraybill B, Shokat K, Schultz PG. Phage-display evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers. 2001; 60(3):220-8. PMID: 11774228.
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    301. Shogren-Knaak MA, Alaimo PJ, Shokat K. Recent advances in chemical approaches to the study of biological systems. Annu Rev Cell Dev Biol. 2001; 17:405-33. PMID: 11687495.
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    302. Liu Y, Witucki LA, Shah K, Bishop AC, Shokat K. Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities. Biochemistry. 2000 Nov 28; 39(47):14400-8. PMID: 11087392.
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    303. Weiss EL, Bishop AC, Shokat K, Drubin DG. Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nat Cell Biol. 2000 Oct; 2(10):677-85. PMID: 11025657.
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    304. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat K. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21; 407(6802):395-401. PMID: 11014197.
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    305. Weintraub BC, Jun JE, Bishop AC, Shokat K, Thomas ML, Goodnow CC. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. J Exp Med. 2000 Apr 17; 191(8):1443-8. PMID: 10770810; PMCID: PMC2193133.
    306. Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat K. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct. 2000; 29:577-606. PMID: 10940260.
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    307. Gillespie PG, Gillespie SK, Mercer JA, Shah K, Shokat K. Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs. J Biol Chem. 1999 Oct 29; 274(44):31373-81. PMID: 10531338.
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    308. Buzko OV, Shokat K. Blocking HIV entry. Nat Struct Biol. 1999 Oct; 6(10):906-8. PMID: 10504719.
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    309. Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat K. Structural basis for selective inhibition of Src family kinases by PP1. Chem Biol. 1999 Sep; 6(9):671-8. PMID: 10467133.
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    310. Bishop AC, Shokat K. Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacol Ther. 1999 May-Jun; 82(2-3):337-46. PMID: 10454210.
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    311. Yang F, Liu Y, Bixby SD, Friedman JD, Shokat K. Highly efficient green fluorescent protein-based kinase substrates. Anal Biochem. 1999 Jan 15; 266(2):167-73. PMID: 9888972.
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    312. Liu Y, Shah K, Yang F, Witucki L, Shokat K. A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorg Med Chem. 1998 Aug; 6(8):1219-26. PMID: 9784863.
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    313. Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4293-8. PMID: 9539730; PMCID: PMC22482.
    314. Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat K. Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol. 1998 Feb 26; 8(5):257-66. PMID: 9501066.
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    315. Liu Y, Shah K, Yang F, Witucki L, Shokat K. Engineering Src family protein kinases with unnatural nucleotide specificity. Chem Biol. 1998 Feb; 5(2):91-101. PMID: 9495830.
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    316. Shah K, Liu Y, Deirmengian C, Shokat K. Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3565-70. PMID: 9108016; PMCID: PMC20479.
    317. Liblau RS, Tisch R, Shokat K, Yang X, Dumont N, Goodnow CC, McDevitt HO. Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):3031-6. PMID: 8610163; PMCID: PMC39756.
    318. Shokat K. Tyrosine kinases: modular signaling enzymes with tunable specificities. Chem Biol. 1995 Aug; 2(8):509-14. PMID: 9383454.
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    319. Shokat K, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature. 1995 May 25; 375(6529):334-8. PMID: 7753200.
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    320. Liblau RS, Pearson CI, Shokat K, Tisch R, Yang XD, McDevitt HO. High-dose soluble antigen: peripheral T-cell proliferation or apoptosis. Immunol Rev. 1994 Dec; 142:193-208. PMID: 7698794.
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    321. Cooke MP, Heath AW, Shokat K, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med. 1994 Feb 01; 179(2):425-38. PMID: 8294858; PMCID: PMC2191355.
    322. Shokat K, Schultz PG. The generation of antibody combining sites containing catalytic residues. Ciba Found Symp. 1991; 159:118-28; discussion 128-34. PMID: 1959444.
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    323. Shokat K, Schultz PG. Catalytic antibodies. Methods Enzymol. 1991; 203:327-51. PMID: 1762563.
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    324. Shokat K, Schultz PG. Catalytic antibodies. Annu Rev Immunol. 1990; 8:335-63. PMID: 2188666.
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    325. Shokat K, Leumann CJ, Sugasawara R, Schultz PG. A new strategy for the generation of catalytic antibodies. Nature. 1989 Mar 16; 338(6212):269-71. PMID: 2922053.
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    326. McClard RW, Shokat K. Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. Biochemistry. 1987 Jun 16; 26(12):3378-84. PMID: 3651388.
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