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Kevan Shokat, PhD

Title(s)Professor & Vice-Chair, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Phone415-514-0472
ORCID ORCID Icon0000-0001-8590-7741 Additional info
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Research 
    Collapse Research Activities and Funding
    Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis
    NIH/NCI R01CA244550Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Improving the efficacy of mTOR inhibition
    NIH/NCI R01CA221969Feb 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids
    NIH/NCI U01CA199241Apr 14, 2016 - Mar 31, 2020
    Role: Co-Principal Investigator
    Drugging the Switch-II Pocket of K-Ras
    NIH/NCI R01CA190408Sep 12, 2014 - Aug 31, 2019
    Role: Principal Investigator
    A Chemical Map of T Cell Signaling
    NIH/NIAID R01AI044009Sep 1, 1998 - Sep 30, 1999
    Role: Principal Investigator
    A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse
    NIH/NIBIB R01EB001987May 1, 1996 - Mar 31, 2013
    Role: Principal Investigator
    ENGINEERING ORTHOGONAL PROTEIN KINASE AND NUCLEOTIDES
    NIH/NCI R01CA070331May 1, 1996 - May 14, 2003
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell. 2020 May 22. Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Krogan NJ, Jackson PK, Narla G, Gordan JD, Shokat KM, Sage J. PMID: 32531271.
      View in: PubMed   Mentions:    Fields:    
    2. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 27     Fields:    
    3. Betacellulin drives therapy resistance in glioblastoma. Neuro Oncol. 2020 Apr 15; 22(4):457-469. Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA. PMID: 31678994.
      View in: PubMed   Mentions:    Fields:    
    4. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329.
      View in: PubMed   Mentions:
    5. PI4KIIIß is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Sci Transl Med. 2020 01 22; 12(527). Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, Duose DY, Solis LM, Mino B, Raso MG, Behrens C, Wistuba II, Scott KL, Smith M, Nguyen K, Lam G, Choong I, Mazumdar A, Hill JL, Gibbons DL, Brown PH, Russell WK, Shokat K, Creighton CJ, Glenn JS, Kurie JM. PMID: 31969487.
      View in: PubMed   Mentions:    Fields:    
    6. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 12 13; 366(6471). Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. PMID: 31831640.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Cooperative Blockade of PKCa and JAK2 Drives Apoptosis in Glioblastoma. Cancer Res. 2020 Feb 15; 80(4):709-718. Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW. PMID: 31806641.
      View in: PubMed   Mentions:    Fields:    
    8. p38? MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin. FASEB J. 2019 Dec; 33(12):13131-13144. Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE. PMID: 31638431.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins. Angew Chem Int Ed Engl. 2019 11 04; 58(45):16314-16319. Zhang Z, Shokat KM. PMID: 31557383.
      View in: PubMed   Mentions: 2     Fields:    
    10. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. 2019 08 06; 58(31):3328-3330. Lou K, Gilbert LA, Shokat KM. PMID: 31343870.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 05 28; 12(583). Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. PMID: 31138768.
      View in: PubMed   Mentions: 2     Fields:    
    12. Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Exp Mol Med. 2019 04 16; 51(4):1-17. Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J. PMID: 30992425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host Microbe. 2019 03 13; 25(3):454-462.e6. Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. PMID: 30827827.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Chronic TGF-ß exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 2019 02 26; 12(570). Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R. PMID: 30808819.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Sci. 2019 03; 28(3):654-662. Wong AW, Urisman A, Burlingame AL, Shokat KM. PMID: 30636329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. ACS Chem Biol. 2018 10 19; 13(10):2956-2965. Ocasio CA, Warkentin AA, McIntyre PJ, Barkovich KJ, Vesely C, Spencer J, Shokat KM, Bayliss R. PMID: 30239186.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Chemical genetic inhibition of DEAD-box proteins using covalent complementarity. Nucleic Acids Res. 2018 09 28; 46(17):8689-8699. Barkovich KJ, Moore MK, Hu Q, Shokat KM. PMID: 30102385.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. Mol Cancer Ther. 2018 12; 17(12):2702-2709. Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK. PMID: 30254185.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. J Vis Exp. 2018 08 28; (138). Chorba JS, Galvan AM, Shokat KM. PMID: 30222160.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nat Chem Biol. 2018 08; 14(8):768-777. Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S. PMID: 29942081.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS One. 2018; 13(5):e0193849. Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. PMID: 29799846.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 05 04; 293(18):6692. Chorba JS, Galvan AM, Shokat KM. PMID: 29728531.
      View in: PubMed   Mentions:    Fields:    
    23. Disease-Causing Mutations in the G Protein Gas Subvert the Roles of GDP and GTP. Cell. 2018 05 17; 173(5):1254-1264.e11. Hu Q, Shokat KM. PMID: 29628140.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model. 2018 02 26; 58(2):464-471. Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N. PMID: 29320178.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 02 09; 293(6):1875-1886. Chorba JS, Galvan AM, Shokat KM. PMID: 29259136.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol. 2017 12 21; 24(12):1455-1466.e14. Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. PMID: 29033317.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. J Med Chem. 2017 12 28; 60(24):9976-9989. Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LD. PMID: 28933846.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    28. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addict Biol. 2018 03; 23(2):713-722. Morisot N, Novotny CJ, Shokat KM, Ron D. PMID: 28681511.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Drugging the 'undruggable' cancer targets. Nat Rev Cancer. 2017 08; 17(8):502-508. Dang CV, Reddy EP, Shokat KM, Soucek L. PMID: 28643779.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    30. Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. ACS Chem Biol. 2017 07 21; 12(7):1956-1962. Novotny CJ, Hamilton GL, McCormick F, Shokat KM. PMID: 28530791.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    31. Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry. 2017 06 27; 56(25):3178-3183. McGregor LM, Jenkins ML, Kerwin C, Burke JE, Shokat KM. PMID: 28621541.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Sci Transl Med. 2017 06 14; 9(394). Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J, Leenders F, Heuckmann JM, Wolf J, Diebold J, Pall G, Peifer M, Aerts M, Gevaert K, Zahedi RP, Buettner R, Shokat KM, McDonald NQ, Kast SM, Gautschi O, Thomas RK, Sos ML. PMID: 28615362.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nat Chem Biol. 2017 Aug; 13(8):842-844. Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat KM, Wang L. PMID: 28604697.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    34. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2017 06 01; 127(6):2438. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. PMID: 28569734.
      View in: PubMed   Mentions:    Fields:    
    35. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. 2017 05 18; 545(7654):311-316. Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. PMID: 28489820.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    36. Long-term oral kinetin does not protect against a-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017 Oct; 109:106-116. Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K. PMID: 28434973.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 03 13; 31(3):424-435. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. PMID: 28292440.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Mol Cancer Res. 2017 06; 15(6):765-775. Reed DE, Shokat KM. PMID: 28196852.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 02; 16(2):265-277. Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. PMID: 27940637.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    40. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Mol Pharmacol. 2017 Jan; 91(1):65-73. Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M. PMID: 27821547.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    41. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cell Signal. 2017 01; 29:78-83. Lazarus MB, Levin RS, Shokat KM. PMID: 27760376.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    42. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nat Chem Biol. 2016 Nov; 12(11):923-930. Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat KM. PMID: 27595329.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    43. From Powerful Review Articles to Research Breakthroughs. Cell Chem Biol. 2016 08 18; 23(8):883-4. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. PMID: 27541190.
      View in: PubMed   Mentions:    Fields:    
    44. Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment. Antioxid Redox Signal. 2017 01 10; 26(2):70-83. Jo A, Choi TG, Jo YH, Jyothi KR, Nguyen MN, Kim JH, Lim S, Shahid M, Akter S, Lee S, Lee KH, Kim W, Cho H, Lee J, Shokat KM, Yoon KS, Kang I, Ha J, Kim SS. PMID: 27357096.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4776-83. Levin RS, Hertz NT, Burlingame AL, Shokat KM, Mukherjee S. PMID: 27482120.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov. 2016 11; 15(11):771-785. Ostrem JM, Shokat KM. PMID: 27469033.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    47. Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Mol Cancer Ther. 2016 07; 15(7):1472-84. Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, Shokat KM, Bandyopadhyay S, Lord CJ, Ashworth A. PMID: 27364904.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    48. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 07; 6(7):727-39. Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. PMID: 27231123.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    49. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 2016 06 09; 534(7606):272-6. Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM. PMID: 27279227.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    50. Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. Anal Chem. 2016 05 17; 88(10):5042-5. Tabaei SR, Guo F, Rutaganira FU, Vafaei S, Choong I, Shokat KM, Glenn JS, Cho NJ. PMID: 27118725.
      View in: PubMed   Mentions: 1     Fields:    
    51. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    52. Our Advisors, Our Ambassadors, Our Editorial Board Members. Cell Chem Biol. 2016 Mar 17; 23(3):311-2. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. PMID: 26991096.
      View in: PubMed   Mentions:    Fields:    
    53. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIß. J Med Chem. 2016 Mar 10; 59(5):1830-9. Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE. PMID: 26885694.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    54. Voices of Chemical Biology: Charting the Next Decade. Cell Chem Biol. 2016 Feb 18; 23(2):199. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. PMID: 26971865.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIß with Rab11. Protein Sci. 2016 Apr; 25(4):826-39. Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. PMID: 26756197.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    56. Cell Chemical Biology: Home of Exciting Chemical Biology. Cell Chem Biol. 2016 Jan 21; 23(1):1-2. Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. PMID: 26933730.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    57. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016 Jan 01; 30(1):117-31. Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP. PMID: 26728557.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    58. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49. Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. PMID: 26650549.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    59. Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture. Antimicrob Agents Chemother. 2016 01; 60(1):570-9. Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD. PMID: 26552986.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    60. Discovery and functional characterization of a neomorphic PTEN mutation. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):13976-81. Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. PMID: 26504226.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    61. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab. 2015 Nov 03; 22(5):907-21. Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. PMID: 26456332.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    62. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 2015 Aug 24; 4. Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. PMID: 26302204.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    63. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorg Med Chem. 2015 Sep 01; 23(17):5483-8. Lazarus MB, Shokat KM. PMID: 26275681.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    64. SR protein kinases promote splicing of nonconsensus introns. Nat Struct Mol Biol. 2015 Aug; 22(8):611-7. Lipp JJ, Marvin MC, Shokat KM, Guthrie C. PMID: 26167880.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    65. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Sci Signal. 2015 Jun 30; 8(383):ra65. Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. PMID: 26126716.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    66. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19; 4. Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. PMID: 25986605.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    67. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. PMID: 26029667.
      View in: PubMed   Mentions:
    68. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015 Apr 17; 11(4):800. Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. PMID: 25888283.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    69. The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. Biochem J. 2015 Apr 01; 467(1):47-62. Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA. PMID: 25583260.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    70. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. ACS Chem Biol. 2015 Jan 16; 10(1):257-61. Lazarus MB, Novotny CJ, Shokat KM. PMID: 25551253.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    71. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 2014 Dec 22; 3. Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM. PMID: 25531068.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    72. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. PMID: 25522764.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    73. Targeting osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18100-1. Reed DE, Shokat KM. PMID: 25512494.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    74. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 02; 5(2):154-67. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. PMID: 25501949.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    75. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 03; 84(5):968-82. Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. PMID: 25456499.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    76. Reflecting on the past and looking forward to the future of bridging chemistry and biology. Chem Biol. 2014 Sep 18; 21(9):1035-6. Crews C, Hertweck C, Shokat K, Suga H, Kostic M. PMID: 25237850.
      View in: PubMed   Mentions:    Fields:    
    77. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. Chorba JS, Shokat KM. PMID: 25210046.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    78. TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. J Appl Physiol (1985). 2014 Oct 15; 117(8):910-20. Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat KM, Sieck GC. PMID: 25170066.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    79. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 08; 26(3):414-427. Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. PMID: 25175806.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    80. Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny. Biol Reprod. 2014 Oct; 91(4):92. Parker N, Falk H, Singh D, Fidaleo A, Smith B, Lopez MS, Shokat KM, Wright WW. PMID: 25165119.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    81. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 2014 Aug 25; 3:e03245. Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF. PMID: 25161195.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    82. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    83. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep. 2014 Aug 21; 8(4):1037-48. Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. PMID: 25127139.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    84. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. PMID: 24961373.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    85. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. PMID: 24908390.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    86. Structures of PI4KIIIß complexes show simultaneous recruitment of Rab11 and its effectors. Science. 2014 May 30; 344(6187):1035-8. Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL. PMID: 24876499.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    87. A crosslinker based on a tethered electrophile for mapping kinase-substrate networks. Chem Biol. 2014 May 22; 21(5):585-90. Riel-Mehan MM, Shokat KM. PMID: 24746561.
      View in: PubMed   Mentions: 3     Fields:    
    88. Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. Methods Enzymol. 2014; 548:xi-xii. Shokat KM. PMID: 25399648.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    89. The logic and design of analog-sensitive kinases and their small molecule inhibitors. Methods Enzymol. 2014; 548:189-213. Lopez MS, Kliegman JI, Shokat KM. PMID: 25399647.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    90. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Rep. 2013 Dec 26; 5(6):1725-36. Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. PMID: 24360963.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    91. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. PMID: 24317039.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    92. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PMID: 24300897.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    93. Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurg. 2014 Feb; 120(2):331-6. Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. PMID: 24286145.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    94. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. 2013 Dec 04; 135(48):18153-9. Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. PMID: 24171479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    95. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28; 503(7477):548-51. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. PMID: 24256730.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansCells
    96. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. PMID: 24135280.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    97. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15; 154(4):737-47. Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM. PMID: 23953109.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    98. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. 2013 Sep 20; 8(9):1931-8. Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. PMID: 23841803.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    99. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. PMID: 23803853.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    100. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med. 2013 Aug; 2(4):496-506. Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS. PMID: 24156022.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    101. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol Cell. 2013 Apr 25; 50(2):250-60. Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. PMID: 23622515.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    102. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 2014 Mar 20; 33(12):1590-600. Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. PMID: 23542178.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    103. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem. 2013 Apr 11; 56(7):3068-77. Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD. PMID: 23470217.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    104. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 05; 17(2):291-302. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH. PMID: 23395175.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    105. News from the Chemistry & Biology editorial team. Chem Biol. 2012 Nov 21; 19(11):1355. Crews C, Shokat K, Suga H, Kostic M. PMID: 23177188.
      View in: PubMed   Mentions:    Fields:    
    106. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012 Dec; 15(12):1645-54. Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. PMID: 23143520.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    107. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol. 2012 Nov; 19(11):1108-15. Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. PMID: 23064645.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    108. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet. 2012 Aug; 8(8):e1002935. Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. PMID: 22927831.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    109. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet. 2012; 8(8):e1002822. Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. PMID: 22876190.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    110. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. PMID: 22802621.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    111. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. PMID: 22772469.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    112. The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. J Biol Chem. 2012 Aug 17; 287(34):29021-34. Young ET, Zhang C, Shokat KM, Parua PK, Braun KA. PMID: 22761425.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    113. In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. PLoS One. 2012; 7(6):e40000. Cibrián Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat KM, Selbach M, Abdelilah-Seyfried S. PMID: 22768194.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    114. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15; 72(16):4214-24. Jang M, Kim Y, Won H, Lim S, K R J, Dashdorj A, Min YH, Kim SY, Shokat KM, Ha J, Kim SS. PMID: 22719067.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    115. Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell. 2012 Jun 08; 46(5):691-704. Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. PMID: 22681890.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    116. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 06; 486(7401):80-4. Dar AC, Das TK, Shokat KM, Cagan RL. PMID: 22678283.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    117. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell. 2012 Jun; 23(12):2388-98. Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG. PMID: 22535525.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    118. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Mol Cell Biol. 2012 Jul; 32(13):2372-83. St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP. PMID: 22508988.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    119. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1019-27. Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. PMID: 22474407.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    120. The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells. 2012 Apr; 30(4):732-40. Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW. PMID: 22232066.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    121. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov. 2012 May; 2(5):450-7. Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA. PMID: 22588882.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    122. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012 Mar 22; 73(6):1127-42. Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. PMID: 22445341.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    123. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. PMID: 22367541.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
    124. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Invest New Drugs. 2012 Dec; 30(6):2219-25. Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. PMID: 22270257.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    125. Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol Cell Proteomics. 2012 May; 11(5):47-59. Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. PMID: 22267324.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    126. Covalent cross-linking of kinases with their corresponding peptide substrates. Methods Mol Biol. 2012; 795:179-90. Statsuk AV, Shokat KM. PMID: 21960223.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    127. A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods Enzymol. 2012; 512:57-69. Simon MD, Shokat KM. PMID: 22910202.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    128. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011 Dec 23; 44(6):878-92. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. PMID: 22137581.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    129. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle. 2011 Oct 15; 10(20):3527-32. Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat KM, Gregan J. PMID: 22030861.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    130. Genetic deletion of trkB.T1 increases neuromuscular function. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C141-53. Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, Talmadge R, Harvey BK, Wyatt RM, Vernon-Pitts E, Zhang C, Shokat K, Fraser-Liggett C, Balice-Gordon RJ, Tessarollo L, Ward CW. PMID: 21865582.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    131. The Cryptosporidium parvum kinome. BMC Genomics. 2011 Sep 30; 12:478. Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R. PMID: 21962082.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    132. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal. 2011 Sep 13; 4(190):ra59. Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. PMID: 21917715.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    133. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15201-6. Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. PMID: 21876130.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    134. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15046-52. Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM. PMID: 21852571.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    135. TrkB and protein kinase M? regulate synaptic localization of PSD-95 in developing cortex. J Neurosci. 2011 Aug 17; 31(33):11894-904. Yoshii A, Murata Y, Kim J, Zhang C, Shokat KM, Constantine-Paton M. PMID: 21849550.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    136. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 06; 9:48. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729334.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    137. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 06; 9:47. Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729333.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    138. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89. Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. PMID: 21678117.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    139. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell. 2011 Jun 10; 42(5):624-36. Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. PMID: 21658603.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    140. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 2011 Apr 21; 472(7343):366-9. Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. PMID: 21441910.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    141. Chemistry & Biology editors announce changes to the editorial team. Chem Biol. 2011 Feb 25; 18(2):141. Crews C, Shokat K, Wohlleben W, Kostic M. PMID: 21338910.
      View in: PubMed   Mentions:    Fields:    
    142. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annu Rev Biochem. 2011; 80:769-95. Dar AC, Shokat KM. PMID: 21548788.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    143. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    144. Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods Mol Biol. 2011; 779:185-97. Salomon D, Zhang C, Shokat KM, Sessa G. PMID: 21837567.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    145. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal. 2010 Dec 21; 3(153):rs4. Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, Colman-Lerner A, Nolan GP, Nesvizhskii AI, Peter M, Loewith R, von Mering C, Aebersold R. PMID: 21177495.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    146. Rewiring of genetic networks in response to DNA damage. Science. 2010 Dec 03; 330(6009):1385-9. Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. PMID: 21127252.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    147. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes Dev. 2010 Dec 01; 24(23):2627-39. Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I. PMID: 21123650.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    148. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. PMID: 21062993.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    149. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec; 12(12):1143-53. Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. PMID: 21037565.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    150. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec; 11(12):1085-92. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. PMID: 21037577.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    151. GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci. 2010 Oct 20; 30(42):13955-65. Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO. PMID: 20962217.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    152. Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Anal Chem. 2010 Nov 01; 82(21):8954-60. Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR. PMID: 20936785.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    153. Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. J Hepatol. 2011 Feb; 54(2):328-39. Tak E, Lee S, Lee J, Rashid MA, Kim YW, Park JH, Park WS, Shokat KM, Ha J, Kim SS. PMID: 21056497.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    154. Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol. 2010 Sep; 17(9):1154-61. Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ. PMID: 20802488.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    155. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 2010 Jul 12; 190(1):89-100. Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. PMID: 20624902.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    156. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Mol Biosyst. 2010 Aug; 6(8):1389-402. Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. PMID: 20582381.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    157. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 2010 May 20; 465(7296):359-62. Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. PMID: 20485436.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    158. A drug-drug interaction crystallizes a new entry point into the UPR. Mol Cell. 2010 Apr 23; 38(2):161-3. Shokat KM. PMID: 20417596.
      View in: PubMed   Mentions: 1     Fields:    
    159. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One. 2010 Apr 22; 5(4):e10251. Sliedrecht T, Zhang C, Shokat KM, Kops GJ. PMID: 20422024.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    160. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science. 2010 Mar 26; 327(5973):1638-42. Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL. PMID: 20339072.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    161. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. PMID: 20338997.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    162. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010 Mar 18; 464(7287):427-30. Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. PMID: 20179705.
      View in: PubMed   Mentions: 564     Fields:    Translation:HumansAnimalsCells
    163. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010 Mar 16; 17(3):249-61. Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. PMID: 20227039.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    164. The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol. 2010 Mar; 6(3):244. Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL. PMID: 20154668.
      View in: PubMed   Mentions: 10     Fields:    
    165. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. PMID: 20194733.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    166. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol. 2010 Mar 01; 2(1):15-36. Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. PMID: 23836541.
      View in: PubMed   Mentions: 30     Fields:    
    167. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol. 2010 Feb 26; 17(2):123-34. Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM. PMID: 20189103.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    168. Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem. 2010 Apr 09; 285(15):11093-9. An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ. PMID: 20157113.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    169. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer. 2010 02; 10(2):130-7. Knight ZA, Lin H, Shokat KM. PMID: 20094047.
      View in: PubMed   Mentions: 192     Fields:    Translation:Humans
    170. The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol. 2010 Feb; 6(2):117-24. Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL. PMID: 20081827.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    171. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med. 2010 Jan 27; 2(16):16ra7. Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. PMID: 20371474.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    172. New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). Curr Top Microbiol Immunol. 2010; 347:241-62. Feldman ME, Shokat KM. PMID: 20549474.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    173. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. PMID: 19996317.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    174. Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol Cell. 2009 Nov 13; 36(3):393-404. Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM. PMID: 19917248.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    175. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science. 2009 Oct 09; 326(5950):294-8. Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. PMID: 19815777.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    176. Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Anal Biochem. 2010 Feb 15; 397(2):139-43. Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA. PMID: 19819215.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    177. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18351-6. Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK. PMID: 19805051.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    178. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol. 2009 Oct; 29(20):5455-64. Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL. PMID: 19667075.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    179. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol. 2009 Sep; 29(17):4852-63. Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S. PMID: 19581288.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    180. PIKfyve regulation of endosome-linked pathways. Traffic. 2009 Jul; 10(7):883-93. de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ. PMID: 19582903.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    181. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009 Jun 16; 7(6):e1000134. Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. PMID: 19547744.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    182. Inhibitor hijacking of Akt activation. Nat Chem Biol. 2009 Jul; 5(7):484-93. Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. PMID: 19465931.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansCells
    183. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009 May 05; 7(5):e1000111. Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. PMID: 19468302.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    184. Tuning the activation threshold of a kinase network by nested feedback loops. Science. 2009 Apr 24; 324(5926):509-12. Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. PMID: 19390045.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    185. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. J Biol Chem. 2009 May 29; 284(22):15289-98. Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G. PMID: 19332544.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    186. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Mol Cell. 2009 Mar 27; 33(6):738-51. Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP. PMID: 19328067.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    187. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clin Cancer Res. 2009 Apr 01; 15(7):2311-22. Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, Hann B, Blair J, Shokat K, Welm AL, Moasser MM. PMID: 19318475.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    188. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28; 113(22):5549-57. Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. PMID: 19318683.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    189. Functional organization of the S. cerevisiae phosphorylation network. Cell. 2009 Mar 06; 136(5):952-63. Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ. PMID: 19269370.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    190. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. PMID: 19209957.
      View in: PubMed   Mentions: 455     Fields:    Translation:AnimalsCells
    191. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics. 2009 Jun; 8(6):1361-81. Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. PMID: 19176519.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    192. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    193. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. PMID: 19147570.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    194. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. Miller AL, Zhang C, Shokat KM, Lowell CA. PMID: 19124742.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    195. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 2009 Mar 26; 113(13):2945-54. Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G. PMID: 19139077.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    196. Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 2009 Jan 09; 136(1):50-61. Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH. PMID: 19135888.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    197. Tuning a three-component reaction for trapping kinase substrate complexes. J Am Chem Soc. 2008 Dec 24; 130(51):17568-74. Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. PMID: 19053485.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    198. The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 05; 457(7230):687-93. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. PMID: 19079236.
      View in: PubMed   Mentions: 216     Fields:    Translation:AnimalsCells
    199. Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20740-5. Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS. PMID: 19074277.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    200. Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Mol Cell. 2008 Dec 05; 32(5):662-72. Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP. PMID: 19061641.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    201. Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci. 2008 Dec 15; 121(Pt 24):4124-33. Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B. PMID: 19033389.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    202. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci. 2008 Nov 12; 28(46):11890-9. Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. PMID: 19005054.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    203. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell. 2008 Nov 07; 32(3):394-405. Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. PMID: 18995837.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    204. A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem. 2008 Dec 19; 283(51):35889-98. Shirra MK, McCartney RR, Zhang C, Shokat KM, Schmidt MC, Arndt KM. PMID: 18955495.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    205. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20; 15(10):1015-22. Dar AC, Lopez MS, Shokat KM. PMID: 18940662.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    206. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Res. 2008 Oct 15; 68(20):8361-8. Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. PMID: 18922908.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    207. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov; 4(11):691-9. Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. PMID: 18849971.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    208. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell. 2008 Dec; 19(12):5559-78. Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffery JM, Luca FC. PMID: 18843045.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    209. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J. 2008 Oct 01; 415(1):97-110. Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. PMID: 18498248.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    210. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol. 2008 Oct; 122(4):811-819.e2. Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ. PMID: 19014771.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    211. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008 Oct 01; 68(19):8127-36. Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PMID: 18829572.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    212. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. J Biol Chem. 2008 Dec 19; 283(51):35756-62. Bateman RL, Rauh D, Tavshanjian B, Shokat KM. PMID: 18826943.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    213. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Dev. 2008 Sep 22; 3:23. Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. PMID: 18808695.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    214. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol. 2008 Oct; 15(10):1122-4. Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat KM, Luger K. PMID: 18794842.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    215. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2008 Sep; 118(9):3038-50. Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. PMID: 18704194.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    216. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 2008 Aug 12; 14(2):180-92. Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. PMID: 18691552.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    217. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. Eur J Neurosci. 2008 Sep; 28(5):997-1002. Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. PMID: 18671735.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    218. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F843-50. Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. PMID: 18653476.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    219. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol. 2008 Aug; 4(8):498-506. Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. PMID: 18622389.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    220. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev. 2008 Jul 01; 22(13):1804-15. Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M. PMID: 18593881.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    221. Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. J Mol Biol. 2008 Sep 05; 381(3):540-9. Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y. PMID: 18588899.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    222. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 2008 Sep; 22(9):1698-706. Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PMID: 18548104.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    223. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7797-802. Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. PMID: 18509048.
      View in: PubMed   Mentions: 337     Fields:    Translation:AnimalsCells
    224. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res. 2008 Jul 01; 314(11-12):2299-312. Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D. PMID: 18514190.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    225. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr; 7(4):841-50. Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. PMID: 18413797.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    226. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem. 2008 May 30; 283(22):15419-30. Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. PMID: 18378687.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    227. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev. 2008 Feb 01; 22(3):386-97. Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM. PMID: 18245450.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    228. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1442-7. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. PMID: 18234856.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    229. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry. 2008 Feb 12; 47(6):1599-607. Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T. PMID: 18205404.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    230. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell. 2008 Feb; 19(2):711-21. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. PMID: 18077555.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    231. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat Chem Biol. 2007 Dec; 3(12):739-44. Weiss WA, Taylor SS, Shokat KM. PMID: 18007642.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    232. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 Nov 09; 318(5852):944-9. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. PMID: 17991856.
      View in: PubMed   Mentions: 541     Fields:    Translation:HumansAnimalsCells
    233. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem. 2008 Jan 04; 283(1):222-30. Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. PMID: 17991748.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    234. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. PMID: 18022565.
      View in: PubMed   Mentions: 47     Fields:    
    235. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. PMID: 17911242.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    236. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15759-64. Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. PMID: 17893331.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    237. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem. 2007 Nov 09; 282(45):33052-63. Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO. PMID: 17875639.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    238. A remodelled protease that cleaves phosphotyrosine substrates. J Am Chem Soc. 2007 Sep 26; 129(38):11672-3. Knight ZA, Garrison JL, Chan K, King DS, Shokat KM. PMID: 17803306.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    239. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007 Sep 01; 67(17):7960-5. Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. PMID: 17804702.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    240. Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Org Biomol Chem. 2007 Oct 21; 5(20):3363-7. Bateman R, Rauh D, Shokat KM. PMID: 17912391.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    241. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. PMID: 17486086.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    242. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe. 2007 Apr 19; 1(2):121-33. Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. PMID: 18005690.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    243. Chemically targeting the PI3K family. Biochem Soc Trans. 2007 Apr; 35(Pt 2):245-9. Knight ZA, Shokat KM. PMID: 17371250.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    244. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5812-7. Kanin EI, Kipp RT, Kung C, Slattery M, Viale A, Hahn S, Shokat KM, Ansari AZ. PMID: 17392431.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    245. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell. 2007 Mar 23; 25(6):839-50. Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. PMID: 17386261.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    246. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 2007 Mar 09; 128(5):1003-12. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. PMID: 17350582.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    247. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4383-8. Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV. PMID: 17360533.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    248. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr; 3(4):229-38. Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. PMID: 17334377.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    249. Chemical genetics: where genetics and pharmacology meet. Cell. 2007 Feb 09; 128(3):425-30. Knight ZA, Shokat KM. PMID: 17289560.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    250. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature. 2007 Jan 25; 445(7126):437-41. Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. PMID: 17206155.
      View in: PubMed   Mentions: 338     Fields:    Translation:Cells
    251. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc. 2007; 2(11):2996-3000. Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat KM. PMID: 18007635.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    252. A membrane capture assay for lipid kinase activity. Nat Protoc. 2007; 2(10):2459-66. Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM. PMID: 17947987.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    253. Structure and properties of a re-engineered homeodomain protein-DNA interface. ACS Chem Biol. 2006 Dec 15; 1(12):755-60. Simon MD, Feldman ME, Rauh D, Maris AE, Wemmer DE, Shokat KM. PMID: 17240973.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    254. Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. 2006 Dec; 174(4):1767-74. Wan L, Zhang C, Shokat KM, Hollingsworth NM. PMID: 17057233.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    255. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006 Nov 24; 281(47):36369-77. Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T. PMID: 17003043.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    256. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell. 2006 Sep 15; 23(6):899-911. Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. PMID: 16973441.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    257. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31; 174(3):437-45. Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. PMID: 16864657.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    258. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J. 2006 Aug; 47(4):532-46. Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman MA, Shokat KM, Rietz S, Parker J, Mundy J. PMID: 16813576.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    259. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Mol Pain. 2006 Jun 15; 2:21. Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M. PMID: 16776832.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    260. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. PMID: 16697955.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    261. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19; 125(4):733-47. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. PMID: 16647110.
      View in: PubMed   Mentions: 385     Fields:    Translation:HumansAnimalsCells
    262. Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. ACS Chem Biol. 2006 Apr 25; 1(3):139-40. Allen JJ, Shokat KM. PMID: 17163659.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    263. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr; 13(4):399-407. Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. PMID: 16632252.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    264. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr; 5(4):885-92. Sturgeon CM, Knight ZA, Shokat KM, Roberge M. PMID: 16648558.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    265. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell. 2006 Mar 03; 21(5):701-10. Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. PMID: 16507367.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    266. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle. 2006 Mar; 5(5):546-54. Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat KM, Fisher RP. PMID: 16552187.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    267. Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett. 2006 Jan 09; 580(1):179-83. Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO. PMID: 16364312.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    268. Combining chemical genetics and proteomics to identify protein kinase substrates. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):17940-5. Dephoure N, Howson RW, Blethrow JD, Shokat KM, O'Shea EK. PMID: 16330754.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    269. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan; 13(1):55-62. Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP. PMID: 16327805.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    270. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat Cell Biol. 2006 Jan; 8(1):78-83. Pinsky BA, Kung C, Shokat KM, Biggins S. PMID: 16327780.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    271. Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem. 2005 Oct 14; 280(41):35051-61. Kenski DM, Zhang C, von Zastrow M, Shokat KM. PMID: 16081410.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    272. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell. 2005 Jul 22; 19(2):223-34. D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat KM, Amon A. PMID: 16039591.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    273. Features of selective kinase inhibitors. Chem Biol. 2005 Jun; 12(6):621-37. Knight ZA, Shokat KM. PMID: 15975507.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimals
    274. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat Methods. 2005 Jun; 2(6):435-41. Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. PMID: 15908922.
      View in: PubMed   Mentions: 50     Fields:    
    275. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005 May 27; 308(5726):1318-21. Cohen MS, Zhang C, Shokat KM, Taunton J. PMID: 15919995.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    276. Chemicals call bacteria, and a new membrane protein machine answers. Cell. 2005 Apr 22; 121(2):163-6. Shokat KM. PMID: 15851024.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    277. Bio-orthogonal affinity purification of direct kinase substrates. J Am Chem Soc. 2005 Apr 20; 127(15):5288-9. Allen JJ, Lazerwith SE, Shokat KM. PMID: 15826144.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    278. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg Med Chem. 2005 Apr 15; 13(8):2825-36. Alaimo PJ, Knight ZA, Shokat KM. PMID: 15781393.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    279. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. PMID: 15820690.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    280. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May; 3(5):e128. Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KM, Adams CL. PMID: 15799708.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    281. The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell. 2005 Mar 25; 120(6):887-99. Muratani M, Kung C, Shokat KM, Tansey WP. PMID: 15797387.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    282. Small-molecule kinase-inhibitor target assessment. Chembiochem. 2005 Mar; 6(3):523-6. Kung C, Shokat KM. PMID: 15696508.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    283. Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3587-92. Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM. PMID: 15738404.
      View in: PubMed   Mentions: 16     Fields:    
    284. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol. 2005 Jan 26; 15(2):160-5. Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. PMID: 15668173.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    285. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17456-61. Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON. PMID: 15505216.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    286. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 01; 12(17):4749-59. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. PMID: 15358300.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    287. A mechanism-based cross-linker for the identification of kinase-substrate pairs. J Am Chem Soc. 2004 Aug 04; 126(30):9160-1. Maly DJ, Allen JA, Shokat KM. PMID: 15281787.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    288. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev Technol. 2004 Aug; 2(4):431-41. Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL. PMID: 15357924.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    289. A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Res. 2004; 32(12):3623-31. Simon MD, Sato K, Weiss GA, Shokat KM. PMID: 15247345.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    290. Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. J Am Chem Soc. 2004 Jul 07; 126(26):8078-9. Simon MD, Shokat KM. PMID: 15225024.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    291. Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chem Biol. 2004 Jul; 11(7):1017-23. Sato K, Simon MD, Levin AM, Shokat KM, Weiss GA. PMID: 15271360.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    292. Design and use of analog-sensitive protein kinases. Curr Protoc Mol Biol. 2004 May; Chapter 18:Unit 18.11. Blethrow J, Zhang C, Shokat KM, Weiss EL. PMID: 18265343.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    293. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1868-73. Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA. PMID: 14766983.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    294. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol. 2004 Feb; 24(4):1721-35. Liu Y, Kung C, Fishburn J, Ansari AZ, Shokat KM, Hahn S. PMID: 14749387.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    295. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett. 2004 Jan 02; 556(1-3):26-34. Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. PMID: 14706820.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    296. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res. 2003 Dec 15; 63(24):8930-8. Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. PMID: 14695210.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    297. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol Biol Cell. 2004 Jan; 15(1):11-23. Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM. PMID: 14595109.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    298. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. PMID: 14574415.
      View in: PubMed   Mentions: 379     Fields:    Translation:AnimalsCells
    299. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. Papa FR, Zhang C, Shokat K, Walter P. PMID: 14564015.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    300. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol Cell Biol. 2003 Sep; 23(17):6327-37. Sreenivasan A, Bishop AC, Shokat KM, Kellogg DR. PMID: 12917352.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    301. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol. 2003 Sep 01; 162(5):765-72. Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat KM, Wendland B, McDonald KL, McCaffery JM, Drubin DG. PMID: 12952930.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    302. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol. 2003 Sep; 21(9):1047-54. Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM. PMID: 12923550.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    303. Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development. J Immunol. 2003 Jul 15; 171(2):519-23. Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A. PMID: 12847211.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    304. Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry. 2003 Jul 08; 42(26):7915-21. Ulrich SM, Kenski DM, Shokat KM. PMID: 12834343.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    305. Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev. 2003 Jun 15; 17(12):1524-39. Benjamin KR, Zhang C, Shokat KM, Herskowitz I. PMID: 12783856.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    306. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4287-92. Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. PMID: 12646704.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    307. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem. 2003 Apr 25; 278(17):14926-35. Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ. PMID: 12594221.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    308. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell. 2003 Feb; 14(2):477-90. Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ. PMID: 12589048.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    309. A chemical genetic approach for the identification of direct substrates of protein kinases. Methods Mol Biol. 2003; 233:253-71. Shah K, Shokat KM. PMID: 12840513.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    310. Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3223-7. Ulrich SM, Sallee NA, Shokat KM. PMID: 12372539.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    311. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc. 2002 Oct 16; 124(41):12118-28. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. PMID: 12371851.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    312. A kinase sequence database: sequence alignments and family assignment. Bioinformatics. 2002 Sep; 18(9):1274-5. Buzko O, Shokat KM. PMID: 12217924.
      View in: PubMed   Mentions: 20     Fields:    
    313. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol. 2002 Sep 02; 158(5):885-900. Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. PMID: 12196508.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    314. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Curr Biol. 2002 Aug 20; 12(16):1386-94. Fan QW, Zhang C, Shokat KM, Weiss WA. PMID: 12194819.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    315. Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discov Today. 2002 Aug 15; 7(16):872-9. Shokat K, Velleca M. PMID: 12546954.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    316. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. J Biol Chem. 2002 Aug 09; 277(32):28916-22. Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS. PMID: 12034735.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    317. The emerging power of chemical genetics. Curr Opin Cell Biol. 2002 Apr; 14(2):155-9. Specht KM, Shokat KM. PMID: 11891113.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    318. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 2002 Feb 08; 108(3):371-81. Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. PMID: 11853671.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    319. Chemical Genetic Analysis of Protein Kinase Cascades. ScientificWorldJournal. 2002; 2:108-110. Alaimo PJ, Shogren-Knaak MA, Shokat KM. PMID: 29973826.
      View in: PubMed   Mentions:    Fields:    
    320. Modified AutoDock for accurate docking of protein kinase inhibitors. J Comput Aided Mol Des. 2002 Feb; 16(2):113-27. Buzko OV, Bishop AC, Shokat KM. PMID: 12188021.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    321. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem Biol. 2002 Jan; 9(1):35-47. Shah K, Shokat KM. PMID: 11841937.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    322. Green fluorescent protein-based protein kinase biosensor substrates. Methods Mol Biol. 2002; 183:275-85. Ulrich S, Shokat K. PMID: 12136762.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    323. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol. 2002 Jan; 9(1):25-33. Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM. PMID: 11841936.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    324. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12578-83. Carroll AS, Bishop AC, DeRisi JL, Shokat KM, O'Shea EK. PMID: 11675494.
      View in: PubMed   Mentions: 43     Fields:    
    325. Chemical genetic approaches for the elucidation of signaling pathways. Curr Opin Chem Biol. 2001 Aug; 5(4):360-7. Alaimo PJ, Shogren-Knaak MA, Shokat KM. PMID: 11470597.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    326. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol. 2001 Jul; 41(2):463-76. Schauder S, Shokat K, Surette MG, Bassler BL. PMID: 11489131.
      View in: PubMed   Mentions: 279     Fields:    Translation:Cells
    327. Magic bullets for protein kinases. Trends Cell Biol. 2001 Apr; 11(4):167-72. Bishop AC, Buzko O, Shokat KM. PMID: 11306297.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    328. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. J Biol Chem. 2001 May 25; 276(21):18090-5. Habelhah H, Shah K, Huang L, Burlingame AL, Shokat KM, Ronai Z. PMID: 11259409.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    329. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol. 2001 Mar; 3(3):325-30. Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. PMID: 11231586.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    330. Phage-display evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers. 2001; 60(3):220-8. Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. PMID: 11774228.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    331. Recent advances in chemical approaches to the study of biological systems. Annu Rev Cell Dev Biol. 2001; 17:405-33. Shogren-Knaak MA, Alaimo PJ, Shokat KM. PMID: 11687495.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    332. Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities. Biochemistry. 2000 Nov 28; 39(47):14400-8. Liu Y, Witucki LA, Shah K, Bishop AC, Shokat KM. PMID: 11087392.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    333. Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nat Cell Biol. 2000 Oct; 2(10):677-85. Weiss EL, Bishop AC, Shokat KM, Drubin DG. PMID: 11025657.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    334. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21; 407(6802):395-401. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. PMID: 11014197.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansAnimalsCells
    335. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. J Exp Med. 2000 Apr 17; 191(8):1443-8. Weintraub BC, Jun JE, Bishop AC, Shokat KM, Thomas ML, Goodnow CC. PMID: 10770810.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    336. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct. 2000; 29:577-606. Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM. PMID: 10940260.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    337. Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs. J Biol Chem. 1999 Oct 29; 274(44):31373-81. Gillespie PG, Gillespie SK, Mercer JA, Shah K, Shokat KM. PMID: 10531338.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    338. Blocking HIV entry. Nat Struct Biol. 1999 Oct; 6(10):906-8. Buzko OV, Shokat KM. PMID: 10504719.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    339. Structural basis for selective inhibition of Src family kinases by PP1. Chem Biol. 1999 Sep; 6(9):671-8. Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM. PMID: 10467133.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    340. Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacol Ther. 1999 May-Jun; 82(2-3):337-46. Bishop AC, Shokat KM. PMID: 10454210.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    341. Highly efficient green fluorescent protein-based kinase substrates. Anal Biochem. 1999 Jan 15; 266(2):167-73. Yang F, Liu Y, Bixby SD, Friedman JD, Shokat KM. PMID: 9888972.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    342. A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorg Med Chem. 1998 Aug; 6(8):1219-26. Liu Y, Shah K, Yang F, Witucki L, Shokat KM. PMID: 9784863.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    343. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4293-8. Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. PMID: 9539730.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    344. Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol. 1998 Feb 26; 8(5):257-66. Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM. PMID: 9501066.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    345. Engineering Src family protein kinases with unnatural nucleotide specificity. Chem Biol. 1998 Feb; 5(2):91-101. Liu Y, Shah K, Yang F, Witucki L, Shokat KM. PMID: 9495830.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    346. Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3565-70. Shah K, Liu Y, Deirmengian C, Shokat KM. PMID: 9108016.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    347. Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):3031-6. Liblau RS, Tisch R, Shokat K, Yang X, Dumont N, Goodnow CC, McDevitt HO. PMID: 8610163.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    348. Tyrosine kinases: modular signaling enzymes with tunable specificities. Chem Biol. 1995 Aug; 2(8):509-14. Shokat KM. PMID: 9383454.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    349. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature. 1995 May 25; 375(6529):334-8. Shokat KM, Goodnow CC. PMID: 7753200.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    350. High-dose soluble antigen: peripheral T-cell proliferation or apoptosis. Immunol Rev. 1994 Dec; 142:193-208. Liblau RS, Pearson CI, Shokat K, Tisch R, Yang XD, McDevitt HO. PMID: 7698794.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    351. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med. 1994 Feb 01; 179(2):425-38. Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC. PMID: 8294858.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    352. The generation of antibody combining sites containing catalytic residues. Ciba Found Symp. 1991; 159:118-28; discussion 128-34. Shokat KM, Schultz PG. PMID: 1959444.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    353. Catalytic antibodies. Methods Enzymol. 1991; 203:327-51. Shokat KM, Schultz PG. PMID: 1762563.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    354. Catalytic antibodies. Annu Rev Immunol. 1990; 8:335-63. Shokat KM, Schultz PG. PMID: 2188666.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    355. A new strategy for the generation of catalytic antibodies. Nature. 1989 Mar 16; 338(6212):269-71. Shokat KM, Leumann CJ, Sugasawara R, Schultz PG. PMID: 2922053.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    356. Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. Biochemistry. 1987 Jun 16; 26(12):3378-84. McClard RW, Shokat KM. PMID: 3651388.
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