James Koh • UCSF Profiles

James Koh, PhD

Title(s)	Professor, Surgery
School	School of Medicine
Address	513 Parnassus Avenue, HSE, #563 San Francisco CA 94143
Phone	415-514-9648
Pronouns	He/Him/His
vCard	Download vCard

Biography

Education and Training

University of California, San Francisco, CA		2019	Diversity, Equity, and Inclusion Champion Training
Harvard University, Cambridge, MA		1997	Postdoctoral Fellowship
University of Michigan, Ann Arbor, MI	Ph.D.	1994	Human Genetics
University of Michigan, Ann Arbor, MI	M.S.	1988	Human Genetics
University of North Carolina, Chapel Hill, NC	BA	1983	Zoology/Classics
Phillips Exeter Academy, Exeter, NH		1979

Research

Research Activities and Funding

Understanding MEN4: Improved screening and functional assessment
Mental Insight Foundation A142592Jan 1, 2024 - Dec 31, 2026
Role: Principal Investigator
Description: The goal of this study is to (1) develop an improved testing algorithm based on functional readouts at the cellular level; (2) determine whether unrecognized MEN4 mutations are present in a wider group of patients who exhibit MEN characteristics but lack MEN1 mutations; and (3) screen for "second hit" co-factors that could influence tumor development in MEN4 patients.

Vitamin D and beta-amyloid signaling in hyperparathyroidism
NIH RF1AG075742Apr 15, 2023 - Mar 31, 2026
Role: Principal Investigator

Regulation of parathyroid function by the amyloid precursor protein
NIH R21AG070721May 1, 2021 - Jan 31, 2023
Role: Principal Investigator

Spatial profiling of scRNAseq signatures in human parathyroid glands
Hypopara Foundation Hypopara-21-001-01Apr 1, 2021 - Mar 31, 2022
Role: Co-PI
Description: The objective of this proposal is to identify the transcriptionally distinct cellular subpopulations that comprise human parathyroid tissue and map their physical locations in the gland utilizing scRNA sequencing and digital spatial profiling.

Pancreatic islet and parathyroid co-transplantation for treatment of diabetes in intramuscular sites
California Institute of Regenerative Medicine 11437Jul 1, 2019 - Jun 30, 2023
Role: Co-Investigator
Description: The first-in-man PARADIGM trial is aimed at evaluating the safety and efficacy of pancreatic islet and parathyroid gland composite grafts in the intramuscular site. The trial will enroll patients with Type 1 diabetes who are on stable immunosuppressive regimens with well-functioning kidney or liver transplants. We request CIRM CLIN2 award to conduct the PARADIGM trial, including enrollment, transplant, follow-up and mechanistic studies of 8 patients. This single-center trial will be conducted at UCSF, the busiest transplant center in the US with proven clinical excellence in islet transplantation. If successful, this study will help to overcome the engraftment barrier of islet transplantation and enable minimally invasive monitoring of islet grafts long-term.

Single cell analysis of intratumoral heterogeneity in parathyroid neoplasia
NIH R21CA192004Jan 16, 2015 - Feb 28, 2017
Role: Principal Investigator

Molecular Mechanisms of Altered Calcium Sensing in Human Parathyroid Disease
NIH R01DK088188Jun 1, 2010 - May 31, 2016
Role: Co-Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency. PNAS Nexus. 2023 Mar; 2(3):pgad073. Tu CL, Chang W, Sosa JA, Koh J. PMID: 36992820; PMCID: PMC10042281.

View in: PubMed Mentions:
Effects of Multi-stage Procurement on the Viability and Function of Human Donor Parathyroid Glands. J Surg Res. 2022 08; 276:404-415. Kelly YM, Ward C, Zhang R, Syed S, Stock PG, Duh QY, Sosa JA, Koh J. PMID: 35468367.

View in: PubMed Mentions: 1 Fields:
Gen General Surgery
Translation:Humans Animals
Ex Vivo Intact Tissue Analysis Reveals Alternative Calcium-sensing Behaviors in Parathyroid Adenomas. J Clin Endocrinol Metab. 2021 10 21; 106(11):3168-3183. Koh J, Zhang R, Roman S, Duh QY, Gosnell J, Shen W, Suh I, Sosa JA. PMID: 34272844; PMCID: PMC8530711.

View in: PubMed Mentions: Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells
Parathyroid-Targeted Overexpression of Regulator of G-Protein Signaling 5 (RGS5) Causes Hyperparathyroidism in Transgenic Mice. J Bone Miner Res. 2019 05; 34(5):955-963. Balenga N, Koh J, Azimzadeh P, Hogue J, Gabr M, Stains JP, Olson JA. PMID: 30690792; PMCID: PMC8210536.

View in: PubMed Mentions: 8 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Transcriptional profiling reveals distinct classes of parathyroid tumors in PHPT. Endocr Relat Cancer. 2018 04; 25(4):407-420. Koh J, Hogue JA, Roman SA, Scheri RP, Fradin H, Corcoran DL, Sosa JA. PMID: 29475894; PMCID: PMC5826637.

View in: PubMed Mentions: 6 Fields:
End Endocrinology Neo Neoplasms
Translation:Humans
Polyclonal origin of parathyroid tumors is common and is associated with multiple gland disease in primary hyperparathyroidism. Surgery. 2018 01; 163(1):9-14. Shi Y, Azimzadeh P, Jamingal S, Wentworth S, Ferlitch J, Koh J, Balenga N, Olson JA. PMID: 29254595; PMCID: PMC5738672.

View in: PubMed Mentions: 4 Fields:
Gen General Surgery
Translation:Humans
Live-Cell Visualization of Calcium Flux in Vibratome-Cut Thick Sections of Viable Tumor Tissue. Curr Protoc Cell Biol. 2017 Dec 11; 77:4.34.1-4.34.16. Koh J, Hogue JA, Sosa JA. PMID: 29227550.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology
Translation:Humans Cells
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density. Metabolism. 2017 09; 74:22-31. Weber TJ, Koh J, Thomas SM, Hogue JA, Scheri RP, Roman SA, Sosa JA. PMID: 28764845; PMCID: PMC5561769.

View in: PubMed Mentions: 4 Fields:
Met Metabolism
Translation:Humans
Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. J Bone Miner Res. 2017 Mar; 32(3):654-666. Balenga N, Azimzadeh P, Hogue JA, Staats PN, Shi Y, Koh J, Dressman H, Olson JA. PMID: 27760455; PMCID: PMC7211037.

View in: PubMed Mentions: 29 Fields:
Met Metabolism Ort Orthopedics
Translation:Humans Cells
A Novel Ex Vivo Method for Visualizing Live-Cell Calcium Response Behavior in Intact Human Tumors. PLoS One. 2016; 11(8):e0161134. Koh J, Hogue JA, Sosa JA. PMID: 27537691; PMCID: PMC4990350.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Single-cell approaches for molecular classification of endocrine tumors. Curr Opin Oncol. 2016 Jan; 28(1):43-9. Koh J, Allbritton NL, Sosa JA. PMID: 26632769; PMCID: PMC4669879.

View in: PubMed Mentions: 2 Fields:
Neo Neoplasms
Translation:Humans Cells
Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism. J Cell Mol Med. 2016 Feb; 20(2):351-9. Koh J, Hogue JA, Wang Y, DiSalvo M, Allbritton NL, Shi Y, Olson JA, Sosa JA. PMID: 26638194; PMCID: PMC4727552.

View in: PubMed Mentions: 9 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Functional and genetic studies of isolated cells from parathyroid tumors reveal the complex pathogenesis of parathyroid neoplasia. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3092-7. Shi Y, Hogue J, Dixit D, Koh J, Olson JA. PMID: 24510902; PMCID: PMC3939880.

View in: PubMed Mentions: 27 Fields:
Sci Science
Translation:Humans Cells
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. Mol Endocrinol. 2011 May; 25(5):867-76. Koh J, Dar M, Untch BR, Dixit D, Shi Y, Yang Z, Adam MA, Dressman H, Wang X, Gesty-Palmer D, Marks JR, Spurney R, Druey KM, Olson JA. PMID: 21393447; PMCID: PMC3082322.

View in: PubMed Mentions: 26 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. J Clin Endocrinol Metab. 2010 Nov; 95(11):4917-24. Adam MA, Untch BR, Danko ME, Stinnett S, Dixit D, Koh J, Marks JR, Olson JA. PMID: 20685860; PMCID: PMC3205600.

View in: PubMed Mentions: 12 Fields:
End Endocrinology Met Metabolism
Translation:Humans