Kelsey Collins, PhD

Title(s)Assistant Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address35 Medical Center Way, #1027
San Francisco CA 94143
ORCID ORCID Icon0000-0001-7348-7348 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Davis , Davis, CAB.S.06/2011Exercise Biology
    University of Calgary, Calgary, AB, CanadaPh.D.08/2017Biomedical Engineering
    Washington University in St. Louis, St. Louis, MOPostdoctoral Fellowship12/2021Orthopaedic Surgery
    Washington University in St. Louis, St. Louis, MOResearch Instructor03/2023Orthopaedic Surgery
    Collapse Awards and Honors
    Osteoarthritis Research Society International (OARSI)2024Rising Star Basic Science Research Award
    Orthopaedic Research Society 2023  - 2025Early Career Member-At-Large, Board of Directors
    ON (Orthoregeneration Network) Foundation2023ORS/ON Orthoregeneration Award
    Orthopaedic Research Society2021  - 2023Preclinical Models Section Podium Award
    NIH/NIAMS2022  - 2024K99/R00 Pathway to Indepedence Award
    Osteoarthritis and Cartilage Journal 2022Outstanding Peer Reviewer
    Columbia University 2020Rising Stars in Engineering in Health
    Orthopaedic Research Society 2020New Investigator Recognition Award (NIRA)
    Center of Regenerative Medicine2020  - 2021Distinguished Postdoctoral Trainee

    Collapse Overview 
    Collapse Overview
    Kelsey H. Collins, PhD completed her undergraduate work in Exercise Biology at University of California, Davis, and earned her PhD in Biomedical Engineering at University of Calgary under the direction of Dr. Walter Herzog. During her postdoctoral studies in the Guilak Laboratory at Washington University in St. Louis, she created a tissue engineering and regenerative medicine platform to determine the signaling mechanisms between adipose and musculoskeletal tissues. For this work, she received the New Investigator Recognition Award from the Orthopaedic Research Society in 2020 and was named among the inaugural class of Rising Stars in Engineering in Health by Columbia University in 2020. Her transition to independence is supported by an NIH NIAMS K99/R00 Award in which she aims to determine the role of adipokines in osteoarthritis (OA) susceptibility, pain, and generate a new class of OA therapies.

    In the Laboratory for Musculoskeletal Crosstalk, we leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis. Our work aims to delineate fat-cartilage signals that contribute to osteoarthritis susceptibility and pain to generate a new class of regenerative medicine-based therapies. We use in vitro and in vivo approaches, induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches. As pathological fat signaling may play a role in many disease processes, we work to define the mechanisms and create therapies that have implications to aging, obesity, diabetes and other chronic diseases.

    We value diversity in backgrounds and experience. We believe that diversity drives creativity and innovation, and we are dedicated to fostering an inclusive ecosystem where everyone feels valued and respected. Our mission is to improve patient outcomes through exciting, collaborative and innovative approaches in Musculoskeletal Research.

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Fat in Osteoarthritis
    NIH R00AR078949Aug 1, 2023 - Jun 30, 2026
    Role: Principal Investigator
    The Role of Neuroimmune Metabolic Crosstalk in the Onset and Progression of Pain in Osteoarthritis
    Arthritis National Research Foundation Jun 1, 2023
    The Role of Fat in Osteoarthritis
    NIH K99AR078949Apr 24, 2022 - Mar 31, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage. Connect Tissue Res. 2024 Mar; 65(2):117-132. Karjalainen K, Tanska P, Collins KH, Herzog W, Korhonen RK, Moo EK. PMID: 38530304.
      View in: PubMed   Mentions:    Fields:    
    2. Evolution and advancements in genomics and epigenomics in OA research: How far we have come. Osteoarthritis Cartilage. 2024 Feb 28. Ramos YFM, Rice SJ, Ali SA, Pastrello C, Jurisica I, Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Thomas Appleton C, Rockel JS, Kapoor M. PMID: 38428513.
      View in: PubMed   Mentions:    Fields:    
    3. Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies. Osteoarthritis Cartilage. 2024 Apr; 32(4):385-397. Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Thomas Appleton C, Rockel JS, Kapoor M. PMID: 38049029.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model. Cartilage. 2023 Sep 01; 19476035231193090. Abughazaleh N, Boldt K, Rios JL, Mattiello SM, Collins KH, Seerattan RA, Herzog W. PMID: 37655800.
      View in: PubMed   Mentions:    Fields:    
    5. Post or perish? Social media strategies for disseminating orthopedic research. J Orthop Res. 2023 08; 41(8):1643-1652. Buettmann EG, Chlebek C, Lockard CA, Clayton SW, Lewis KJ, Collins KH. PMID: 37163368; PMCID: PMC10524931.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy. Gels. 2023 Feb 20; 9(2). Collins KH, Pferdehirt L, Saleh LS, Savadipour A, Springer LE, Lenz KL, Thompson DM, Oswald SJ, Pham CTN, Guilak F. PMID: 36826339; PMCID: PMC9956980.
      View in: PubMed   Mentions: 3  
    7. The role of PIEZO ion channels in the musculoskeletal system. Am J Physiol Cell Physiol. 2023 03 01; 324(3):C728-C740. Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F. PMID: 36717101; PMCID: PMC10027092.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. #OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery. Cureus. 2023 Jan; 15(1):e33978. Halvorson RT, Allahabadi S, Cevallos N, Foley AJ, Collins K, Torres Espin A, Feeley BT, Pandya NK, Bailey JF. PMID: 36814734; PMCID: PMC9939849.
      View in: PubMed   Mentions: 2  
    9. Trimming the fat - is leptin crosstalk the link between obesity and osteoarthritis? Osteoarthritis Cartilage. 2023 01; 31(1):23-25. Collins KH, Guilak F. PMID: 36273787.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Leptin mediates the regulation of muscle mass and strength by adipose tissue. J Physiol. 2022 08; 600(16):3795-3817. Collins KH, Gui C, Ely EV, Lenz KL, Harris CA, Guilak F, Meyer GA. PMID: 35844058; PMCID: PMC9378542.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery. Sci Adv. 2021 Sep 03; 7(36):eabj1414. Choi YR, Collins KH, Springer LE, Pferdehirt L, Ross AK, Wu CL, Moutos FT, Harasymowicz NS, Brunger JM, Pham CTN, Guilak F. PMID: 34516920; PMCID: PMC8442875.
      View in: PubMed   Mentions: 13     Fields:    
    12. Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury. Sci Rep. 2021 07 15; 11(1):14560. Collins KH, Schwartz DJ, Lenz KL, Harris CA, Guilak F. PMID: 34267289; PMCID: PMC8282619.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption. Appl Physiol Nutr Metab. 2021 Nov; 46(11):1389-1399. Smith IC, Ostertag C, O'Reilly JJ, Rios JL, Klancic T, MacDonald GZ, Collins KH, Reimer RA, Herzog W. PMID: 34139131.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Immunoengineering the next generation of arthritis therapies. Acta Biomater. 2021 10 01; 133:74-86. Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. PMID: 33823324; PMCID: PMC8941669.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. Adipose tissue is a critical regulator of osteoarthritis. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Collins KH, Lenz KL, Pollitt EN, Ferguson D, Hutson I, Springer LE, Oestreich AK, Tang R, Choi YR, Meyer GA, Teitelbaum SL, Pham CTN, Harris CA, Guilak F. PMID: 33443201; PMCID: PMC7817130.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    16. Is Obesity a Disease of Stem Cells? Cell Stem Cell. 2020 07 02; 27(1):15-18. Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F. PMID: 32619511; PMCID: PMC8715393.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction. J Physiol. 2020 07; 598(13):2669-2683. Biltz NK, Collins KH, Shen KC, Schwartz K, Harris CA, Meyer GA. PMID: 32358797; PMCID: PMC8767374.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    18. Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity. Sci Adv. 2020 05; 6(19):eaaz7492. Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F. PMID: 32426485; PMCID: PMC7209997.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    19. The role of macrophages in osteoarthritis and cartilage repair. Osteoarthritis Cartilage. 2020 05; 28(5):544-554. Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. PMID: 31926267; PMCID: PMC7214213.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    20. Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points. J Sport Health Sci. 2020 03; 9(2):132-139. Collins KH, MacDonald GZ, Hart DA, Seerattan RA, Rios JL, Reimer RA, Herzog W. PMID: 32099721; PMCID: PMC7031772.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    21. Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies. J Orthop Res. 2019 06; 37(6):1287-1293. Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN. PMID: 30977548; PMCID: PMC6546536.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    22. Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity. Sci Rep. 2019 03 07; 9(1):3893. Rios JL, Bomhof MR, Reimer RA, Hart DA, Collins KH, Herzog W. PMID: 30846801; PMCID: PMC6405910.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    23. Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury. Precis Nanomed. 2019; 2(1):245-248. Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN. PMID: 31681908; PMCID: PMC6824724.
      View in: PubMed   Mentions: 4  
    24. Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. FASEB J. 2019 04; 33(4):5153-5167. Paul HA, Collins KH, Nicolucci AC, Urbanski SJ, Hart DA, Vogel HJ, Reimer RA. PMID: 30629464.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    25. Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs. Tissue Eng Regen Med. 2019 08; 16(4):335-343. Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F. PMID: 31413938; PMCID: PMC6675820.
      View in: PubMed   Mentions: 10  Translation:Humans
    26. Association of Metabolic Markers with self-reported osteoarthritis among middle-aged BMI-defined non-obese individuals: a cross-sectional study. BMC Obes. 2018; 5:23. Collins KH, Sharif B, Reimer RA, Sanmartin C, Herzog W, Chin R, Marshall DA. PMID: 30186613; PMCID: PMC6120068.
      View in: PubMed   Mentions: 3  
    27. High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model. Bone Joint Res. 2018 Apr; 7(4):274-281. Collins KH, Hart DA, Seerattan RA, Reimer RA, Herzog W. PMID: 29922445; PMCID: PMC5987701.
      View in: PubMed   Mentions: 22  
    28. Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity. Front Physiol. 2018; 9:112. Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA. PMID: 29527173; PMCID: PMC5829464.
      View in: PubMed   Mentions: 86  
    29. Potential Impact of Metabolic and Gut Microbial Response to Pregnancy and Lactation in Lean and Diet-Induced Obese Rats on Offspring Obesity Risk. Mol Nutr Food Res. 2018 02; 62(4). Paul HA, Collins KH, Bomhof MR, Vogel HJ, Reimer RA. PMID: 29193674.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    30. Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model. Inflamm Res. 2018 Feb; 67(2):139-146. Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA. PMID: 29075814.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    31. Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet. Physiol Rep. 2017 May; 5(10):e13270. Collins KH, Hart DA, Smith IC, Issler AM, Reimer RA, Seerattan RA, Rios JL, Herzog W. PMID: 28533262; PMCID: PMC5449557.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    32. Association of body mass index (BMI) and percent body fat among BMI-defined non-obese middle-aged individuals: Insights from a population-based Canadian sample. Can J Public Health. 2017 03 01; 107(6):e520-e525. Collins KH, Sharif B, Sanmartin C, Reimer RA, Herzog W, Chin R, Marshall DA. PMID: 28252369; PMCID: PMC6972441.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats. Sci Rep. 2016 11 17; 6:37278. Collins KH, Paul HA, Hart DA, Reimer RA, Smith IC, Rios JL, Seerattan RA, Herzog W. PMID: 27853291; PMCID: PMC5112513.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    34. Reduced knee adduction moments for management of knee osteoarthritis:: A three month phase I/II randomized controlled trial. Gait Posture. 2016 10; 50:60-68. Lewinson RT, Vallerand IA, Collins KH, Wiley JP, Lun VMY, Patel C, Woodhouse LJ, Reimer RA, Worobets JT, Herzog W, Stefanyshyn DJ. PMID: 27580080.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    35. High-fat high-sucrose diet leads to dynamic structural and inflammatory alterations in the rat vastus lateralis muscle. J Orthop Res. 2016 12; 34(12):2069-2078. Collins KH, Hart DA, Reimer RA, Seerattan RA, Waters-Banker C, Sibole SC, Herzog W. PMID: 26990324.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    36. Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees. J Orthop Res. 2016 06; 34(6):1010-8. Collins KH, Hart DA, Reimer RA, Seerattan RA, Herzog W. PMID: 26572064.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    37. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthritis Cartilage. 2015 Nov; 23(11):1989-98. Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W. PMID: 26521745.
      View in: PubMed   Mentions: 95     Fields:    Translation:Animals
    38. Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats. Osteoarthritis Cartilage. 2015 Jun; 23(6):957-65. Collins KH, Reimer RA, Seerattan RA, Leonard TR, Herzog W. PMID: 25659656.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    39. Reduced knee joint loading with lateral and medial wedge insoles for management of knee osteoarthritis: a protocol for a randomized controlled trial. BMC Musculoskelet Disord. 2014 Dec 03; 15:405. Lewinson RT, Collins KH, Vallerand IA, Wiley JP, Woodhouse LJ, Reimer RA, Worobets JT, Herzog W, Stefanyshyn DJ. PMID: 25467955; PMCID: PMC4265477.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Ground reaction force estimates from ActiGraph GT3X+ hip accelerations. PLoS One. 2014; 9(6):e99023. Neugebauer JM, Collins KH, Hawkins DA. PMID: 24914946; PMCID: PMC4051663.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
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