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Mark Rubinstein, MD

Title(s)Professor Emeritus, Pediatrics
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-7169-7528 Additional info
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    Collapse Biography 
    Collapse education and training
    Yale-New HavenM.D.1997School of Medicine

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    Collapse Research 
    Collapse research activities and funding
    Adolescent ENDS Use, Nicotine Metabolism and Toxicant Exposure
    NIH R21DA040718Aug 15, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers
    NIH R01DA036508Jul 1, 2009 - May 31, 2015
    Role: Principal Investigator
    Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers
    NIH R01CA140216Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    Nicotine Replacement and Counseling In Adolescents
    NIH K23RR018471Aug 1, 2003 - Jun 30, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cytisinicline for smoking cessation in individuals with self-reported COPD: a post hoc analysis of the ORCA-2 and ORCA-3 trials. Thorax. 2025 Sep 17. Prochaska J, Rubinstein M, Perdok R, Blumenstein B, Jacobs C. PMID: 40962497.
      View in: PubMed   Mentions:    Fields:    
    2. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 01; 185(6):648-655. Rigotti NA, Benowitz NL, Prochaska JJ, Rubinstein M, Clarke A, Blumenstein B, Cain DF, Jacobs C. PMID: 40257755; PMCID: PMC12012700.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    3. Effects of Social Media on Adolescents' Willingness and Intention to Use E-Cigarettes: An Experimental Investigation. Nicotine Tob Res. 2021 03 19; 23(4):694-701. Vogel EA, Ramo DE, Rubinstein ML, Delucchi KL, Darrow SM, Costello C, Prochaska JJ. PMID: 31912147; PMCID: PMC7976937.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    4. Effect of varenicline for smoking cessation in adolescents - Authors' reply. Lancet Child Adolesc Health. 2021 02; 5(2):e4. Gray KM, Rubinstein ML, Prochaska JJ, DuBrava SJ, Holstein AR, Samuels L, McRae TD. PMID: 33484669.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Abuse liability assessment of the JUUL system in two nicotine concentrations compared to combustible cigarette, nicotine gum and comparator electronic nicotine delivery system. Drug Alcohol Depend. 2020 12 01; 217:108441. Goldenson NI, Buchhalter AR, Augustson EM, Rubinstein ML, Van Hoof D, Henningfield JE. PMID: 33250386.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    6. Abuse liability assessment of the JUUL system in four flavors relative to combustible cigarette, nicotine gum and a comparator electronic nicotine delivery system among adult smokers. Drug Alcohol Depend. 2020 12 01; 217:108395. Goldenson NI, Buchhalter AR, Augustson EM, Rubinstein ML, Henningfield JE. PMID: 33176942.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    7. Neural Correlates of Smartphone Dependence in Adolescents. Front Hum Neurosci. 2020; 14:564629. Tymofiyeva O, Yuan JP, Kidambi R, Huang CY, Henje E, Rubinstein ML, Jariwala N, Max JE, Yang TT, Xu D. PMID: 33132878; PMCID: PMC7577047.
      View in: PubMed   Mentions: 17  
    8. High-dose and low-dose varenicline for smoking cessation in adolescents: a randomised, placebo-controlled trial. Lancet Child Adolesc Health. 2020 11; 4(11):837-845. Gray KM, Rubinstein ML, Prochaska JJ, DuBrava SJ, Holstein AR, Samuels L, McRae TD. PMID: 32979939.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    9. Online patient-provider cannabis consultations. Prev Med. 2020 03; 132:105987. Gali K, Narode R, Young-Wolff KC, Rubinstein ML, Rutledge G, Prochaska JJ. PMID: 31954143; PMCID: PMC7035882.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Adolescents' E-Cigarette Use: Increases in Frequency, Dependence, and Nicotine Exposure Over 12 Months. J Adolesc Health. 2019 06; 64(6):770-775. Vogel EA, Prochaska JJ, Ramo DE, Andres J, Rubinstein ML. PMID: 31122507; PMCID: PMC6538303.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    11. Measuring e-cigarette addiction among adolescents. Tob Control. 2020 05; 29(3):258-262. Vogel EA, Prochaska JJ, Rubinstein ML. PMID: 31079033; PMCID: PMC7738215.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    12. Measuring E-cigarette Addiction among Adolescents. Tobacco Control. 2019; In Press. Vogel EA, Prochaska JJ, Rubinstein ML.
    13. Adolescents’ E-Cigarette Use: Increases in Frequency, Dependence, and Nicotine Exposure over 12 Months. Journal of Adolescent Health. 2019; In Press. Vogel EA, Prochaska JJ, Ramo DE, Jerome A, Rubinstein ML.
    14. Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing. J Hematol Oncol. 2018 12 21; 11(1):142. Li Z, Song W, Rubinstein M, Liu D. PMID: 30577797; PMCID: PMC6303854.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    15. Associations between marijuana use and tobacco cessation outcomes in young adults. J Subst Abuse Treat. 2018 11; 94:69-73. Vogel EA, Rubinstein ML, Prochaska JJ, Ramo DE. PMID: 30243420; PMCID: PMC6190592.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    16. Author Response. Pediatrics. 2018 06; 141(6). Rubinstein ML. PMID: 29853622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Prevalence and correlates of adolescents' e-cigarette use frequency and dependence. Drug Alcohol Depend. 2018 07 01; 188:109-112. Vogel EA, Ramo DE, Rubinstein ML. PMID: 29763848; PMCID: PMC5999577.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    18. Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes. Pediatrics. 2018 04; 141(4). Rubinstein ML, Delucchi K, Benowitz NL, Ramo DE. PMID: 29507165; PMCID: PMC5869331.
      View in: PubMed   Mentions: 83     Fields:    Translation:Humans
    19. Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. Neurosci Biobehav Rev. 2017 Jan; 72:176-189. England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, Gould TJ, Hatsukami D, Jensen F, Kandel D, Lanphear B, Leslie F, Pauly JR, Neiderhiser J, Rubinstein M, Slotkin TA, Spindel E, Stroud L, Wakschlag L. PMID: 27890689; PMCID: PMC5965681.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimals
    20. Polydrug use among urban adolescent cigarette smokers. Addict Behav. 2017 03; 66:145-150. McKelvey KL, Ramo DE, Delucchi K, Rubinstein ML. PMID: 27979332; PMCID: PMC5501269.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Eating Disorders in Adolescent and Young Adult Males: Presenting Characteristics. J Adolesc Health. 2016 10; 59(4):397-400. Vo M, Lau J, Rubinstein M. PMID: 27287963.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    22. Recruitment of adolescents for a smoking study: use of traditional strategies and social media. Transl Behav Med. 2015 Sep; 5(3):254-9. Rait MA, Prochaska JJ, Rubinstein ML. PMID: 26327930; PMCID: PMC4537465.
      View in: PubMed   Mentions: 26     Fields:    
    23. Reporting of cigar use among adolescent tobacco smokers. Addict Behav. 2016 Feb; 53:206-9. Rait MA, Prochaska JJ, Rubinstein ML. PMID: 26575823; PMCID: PMC4679696.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. Scanning the brain for answers about effectiveness of graphic warning labels. Tob Control. 2015 May; 24(3):211-2. Rubinstein ML. PMID: 25899937.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Exploration of the Effect of Tobacco Smoking on Metabolic Measures in Young People Living with HIV. AIDS Res Treat. 2014; 2014:740545. Rubinstein ML, Harris DR, Rudy BJ, Kapogiannis BG, Aldrovandi GM, Mulligan K. PMID: 25114801; PMCID: PMC4119894.
      View in: PubMed   Mentions: 2  
    26. Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers. Drug Alcohol Depend. 2014 Aug 01; 141:159-62. Rubinstein ML, Rait MA, Prochaska JJ. PMID: 24928480; PMCID: PMC4097075.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    27. Characteristics of adolescent intermittent and daily smokers. Addict Behav. 2014 Sep; 39(9):1337-41. Rubinstein ML, Rait MA, Sen S, Shiffman S. PMID: 24837757; PMCID: PMC4055754.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    28. Race, gender, and nicotine metabolism in adolescent smokers. Nicotine Tob Res. 2013 Jul; 15(7):1311-5. Rubinstein ML, Shiffman S, Rait MA, Benowitz NL. PMID: 23239845; PMCID: PMC3682846.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    29. Nicotine metabolism and addiction among adolescent smokers. Addiction. 2013 Feb; 108(2):406-12. Rubinstein ML, Shiffman S, Moscicki AB, Rait MA, Sen S, Benowitz NL. PMID: 22823143; PMCID: PMC3504133.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    30. Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers. Nicotine Tob Res. 2011 Aug; 13(8):751-5. Rubinstein ML, Luks TL, Dryden WY, Rait MA, Simpson GV. PMID: 21454914; PMCID: PMC3150683.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    31. Smoking-related cue-induced brain activation in adolescent light smokers. J Adolesc Health. 2011 Jan; 48(1):7-12. Rubinstein ML, Luks TL, Moscicki AB, Dryden W, Rait MA, Simpson GV. PMID: 21185518; PMCID: PMC3058837.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    32. Withdrawal in adolescent light smokers following 24-hour abstinence. Nicotine Tob Res. 2009 Feb; 11(2):185-9. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. PMID: 19246428; PMCID: PMC2658900.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    33. A randomized trial of nicotine nasal spray in adolescent smokers. Pediatrics. 2008 Sep; 122(3):e595-600. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. PMID: 18762494; PMCID: PMC2744418.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    34. Who's Smoking? Cotinine versus self-report in adolescent populations. J Adolesc Health. 2008 Sep; 43(3):205-6. Rubinstein ML. PMID: 18710672.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Rate of nicotine metabolism and withdrawal symptoms in adolescent light smokers. Pediatrics. 2008 Sep; 122(3):e643-7. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. PMID: 18762498; PMCID: PMC2722964.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    36. Cotinine levels in relation to smoking behavior and addiction in young adolescent smokers. Nicotine Tob Res. 2007 Jan; 9(1):129-35. Rubinstein ML, Thompson PJ, Benowitz NL, Shiffman S, Moscicki AB. PMID: 17365743.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    37. Clear the air: adolescents' perceptions of the risks associated with secondhand smoke. Prev Med. 2005 Jul; 41(1):16-22. Halpern-Felsher BL, Rubinstein ML. PMID: 15916988.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    38. Perceived risks and benefits of smoking: differences among adolescents with different smoking experiences and intentions. Prev Med. 2004 Sep; 39(3):559-67. Halpern-Felsher BL, Biehl M, Kropp RY, Rubinstein ML. PMID: 15313096.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    39. An evaluation of the use of the transdermal contraceptive patch in adolescents. J Adolesc Health. 2004 May; 34(5):395-401. Rubinstein ML, Halpern-Felsher BL, Irwin CE. PMID: 15093794.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
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