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Norman Oppenheimer, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-3038
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    Collapse Research 
    Collapse Research Activities and Funding
    MERCURY 400 MHZ BROADBAND NMR SYSTEM
    NIH/NCRR S10RR013040May 1, 1998 - Apr 30, 1999
    Role: Principal Investigator
    ALCOHOL DEHYDROGENASE CATALYZED SEQUENTIAL OXIDATIONS
    NIH/NIGMS R01GM052529Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator
    QE 300 NMR SPECTROMETER
    NIH/NCRR S10RR004789May 26, 1989 - May 25, 1990
    Role: Principal Investigator
    MECHANISM OF DOUBLE STRAND SCISSION OF DNA BY BLEOMYCIN
    NIH/NCI R01CA047764Jul 1, 1988 - Dec 31, 1991
    Role: Principal Investigator
    1986 GORDON RESEARCH CONFERENCE--ENZYMES &COENZYMES
    NIH/NIGMS R13GM037198Jun 29, 1986 - Dec 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    MECHANISM OF BLEOMYCIN
    NIH/NCI R01CA026272Jul 1, 1979 - Apr 30, 1986
    Role: Principal Investigator
    STRUCTURE-FUNCTION RELATIONS IN PYRIDINE COENZYMES
    NIH/NIGMS R01GM022982May 1, 1979 - Nov 30, 1997
    Role: Principal Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Malver O, Sebastian MJ, Oppenheimer NJ. Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+). DNA Repair (Amst). 2014 Nov; 23:95-100. PMID: 25280628.
      View in: PubMed
    2. Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. PLoS One. 2012; 7(4):e34918. PMID: 22529956.
      View in: PubMed
    3. Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, Hao Q. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. J Biol Chem. 2009 Oct 02; 284(40):27637-45. PMID: 19640846; PMCID: PMC2785692.
      View in: PubMed, PubMed Central
    4. Graeff R, Liu Q, Kriksunov IA, Kotaka M, Oppenheimer N, Hao Q, Lee HC. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J Biol Chem. 2009 Oct 02; 284(40):27629-36. PMID: 19640843; PMCID: PMC2785691.
      View in: PubMed, PubMed Central
    5. Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F. CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism. Int Immunol. 2006 Jul; 18(7):1029-42. PMID: 16720618.
      View in: PubMed
    6. Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krüger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH. Activation of T cell calcium influx by the second messenger ADP-ribose. J Biol Chem. 2006 Feb 03; 281(5):2489-96. PMID: 16316998.
      View in: PubMed
    7. Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F. CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol. 2005 Mar 15; 174(6):3298-305. PMID: 15749861.
      View in: PubMed
    8. Gerth A, Nieber K, Oppenheimer NJ, Hauschildt S. Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes. Biochem J. 2004 Sep 15; 382(Pt 3):849-56. PMID: 15233622; PMCID: PMC1133960.
      View in: PubMed, PubMed Central
    9. Moreno-García ME, Partida-Sánchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L. CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes. Eur J Biochem. 2004 Mar; 271(5):1025-34. PMID: 15009214.
      View in: PubMed
    10. Partida-Sánchez S, Goodrich S, Kusser K, Oppenheimer N, Randall TD, Lund FE. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Immunity. 2004 Mar; 20(3):279-91. PMID: 15030772.
      View in: PubMed
    11. Partida-Sánchez S, Iribarren P, Moreno-García ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. J Immunol. 2004 Feb 01; 172(3):1896-906. PMID: 14734775.
      View in: PubMed
    12. Lacapère JJ, Boulla G, Lund FE, Primack J, Oppenheimer N, Schuber F, Deterre P. Fluorometric studies of ligand-induced conformational changes of CD38. Biochim Biophys Acta. 2003 Nov 03; 1652(1):17-26. PMID: 14580993.
      View in: PubMed
    13. Jackson MD, Schmidt MT, Oppenheimer NJ, Denu JM. Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J Biol Chem. 2003 Dec 19; 278(51):50985-98. PMID: 14522996.
      View in: PubMed
    14. Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV. Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity. Biochemistry. 2002 May 28; 41(21):6744-51. PMID: 12022878.
      View in: PubMed
    15. Buckley N, Oppenheimer NJ. Reactions of Charged Substrates. 8. The Nucleophilic Substitution Reactions of (4-Methoxybenzyl)dimethylsulfonium Chloride. J Org Chem. 1997 Feb 07; 62(3):540-551. PMID: 11671447.
      View in: PubMed
    16. Buckley N, Oppenheimer NJ. Reactions of Charged Substrates. 6. The Methoxymethyl Carbenium Ion Problem. 1. A Semiempirical Study of the Kinetic and Thermodynamic Stabilities of Linear and Cyclic Oxo- and Thiocarbenium Ions Generated from Pyridinium and Dimethylanilinium Ions. J Org Chem. 1996 Nov 15; 61(23):8039-8047. PMID: 11667787.
      View in: PubMed
    17. Buckley N, Oppenheimer NJ. Reactions of Charged Substrates. 7. The Methoxymethyl Carbenium Ion Problem. 2. A Semiempirical Study of the Kinetic and Thermodynamic Stabilities of Linear and Cyclic Oxo- and Thiocarbenium Ions Generated from Aldehyde Hydrates, Hemiacetals, Acetals, and Methyl Ribosides and Glucosides. J Org Chem. 1996 Nov 15; 61(23):8048-8062. PMID: 11667788.
      View in: PubMed
    18. Buckley N, Oppenheimer NJ. Reactions of Charged Substrates. 5. The Solvolysis and Sodium Azide Substitution Reactions of Benzylpyridinium Ions in Deuterium Oxide. J Org Chem. 1996 Oct 18; 61(21):7360-7372. PMID: 11667662.
      View in: PubMed
    19. Buckley N, Maltby D, Burlingame AL, Oppenheimer NJ. Reactions of Charged Substrates. 4. The Gas-Phase Dissociation of (4-Substituted benzyl)dimethylsulfoniums and -pyridiniums. J Org Chem. 1996 Apr 19; 61(8):2753-2762. PMID: 11667109.
      View in: PubMed
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