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Norman Oppenheimer, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-3038
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    Collapse Research 
    Collapse Research Activities and Funding
    MERCURY 400 MHZ BROADBAND NMR SYSTEM
    NIH/NCRR S10RR013040May 1, 1998 - Apr 30, 1999
    Role: Principal Investigator
    ALCOHOL DEHYDROGENASE CATALYZED SEQUENTIAL OXIDATIONS
    NIH/NIGMS R01GM052529Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator
    QE 300 NMR SPECTROMETER
    NIH/NCRR S10RR004789May 26, 1989 - May 25, 1990
    Role: Principal Investigator
    MECHANISM OF DOUBLE STRAND SCISSION OF DNA BY BLEOMYCIN
    NIH/NCI R01CA047764Jul 1, 1988 - Dec 31, 1991
    Role: Principal Investigator
    1986 GORDON RESEARCH CONFERENCE--ENZYMES &COENZYMES
    NIH/NIGMS R13GM037198Jun 29, 1986 - Dec 31, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    MECHANISM OF BLEOMYCIN
    NIH/NCI R01CA026272Jul 1, 1979 - Apr 30, 1986
    Role: Principal Investigator
    STRUCTURE-FUNCTION RELATIONS IN PYRIDINE COENZYMES
    NIH/NIGMS R01GM022982May 1, 1979 - Nov 30, 1997
    Role: Principal Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Malver O, Sebastian MJ, Oppenheimer N. Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+). DNA Repair (Amst). 2014 Nov; 23:95-100. PMID: 25280628.
      View in: PubMed
    2. Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer N, Stroud RM, Kellenberger E, Schuber F. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. PLoS One. 2012; 7(4):e34918. PMID: 22529956; PMCID: PMC3329556.
    3. Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, Hao Q. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. J Biol Chem. 2009 Oct 2; 284(40):27637-45. PMID: 19640846; PMCID: PMC2785692.
    4. Graeff R, Liu Q, Kriksunov IA, Kotaka M, Oppenheimer N, Hao Q, Lee HC. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J Biol Chem. 2009 Oct 2; 284(40):27629-36. PMID: 19640843; PMCID: PMC2785691.
    5. Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, Oppenheimer N, Santos-Argumedo L, Schuber F. CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism. Int Immunol. 2006 Jul; 18(7):1029-42. PMID: 16720618.
      View in: PubMed
    6. Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krüger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH. Activation of T cell calcium influx by the second messenger ADP-ribose. J Biol Chem. 2006 Feb 3; 281(5):2489-96. PMID: 16316998.
      View in: PubMed
    7. Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F. CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol. 2005 Mar 15; 174(6):3298-305. PMID: 15749861.
      View in: PubMed
    8. Gerth A, Nieber K, Oppenheimer N, Hauschildt S. Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes. Biochem J. 2004 Sep 15; 382(Pt 3):849-56. PMID: 15233622; PMCID: PMC1133960.
    9. Partida-Sánchez S, Goodrich S, Kusser K, Oppenheimer N, Randall TD, Lund FE. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Immunity. 2004 Mar; 20(3):279-91. PMID: 15030772.
      View in: PubMed
    10. Moreno-García ME, Partida-Sánchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L. CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes. Eur J Biochem. 2004 Mar; 271(5):1025-34. PMID: 15009214.
      View in: PubMed
    11. Partida-Sánchez S, Iribarren P, Moreno-García ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. J Immunol. 2004 Feb 1; 172(3):1896-906. PMID: 14734775.
      View in: PubMed
    12. Lacapère JJ, Boulla G, Lund FE, Primack J, Oppenheimer N, Schuber F, Deterre P. Fluorometric studies of ligand-induced conformational changes of CD38. Biochim Biophys Acta. 2003 Nov 3; 1652(1):17-26. PMID: 14580993.
      View in: PubMed
    13. Jackson MD, Schmidt MT, Oppenheimer N, Denu JM. Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J Biol Chem. 2003 Dec 19; 278(51):50985-98. PMID: 14522996.
      View in: PubMed
    14. Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV. Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity. Biochemistry. 2002 May 28; 41(21):6744-51. PMID: 12022878.
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    15. Partida-Sánchez S, Cockayne DA, Monard S, Jacobson EL, Oppenheimer N, Garvy B, Kusser K, Goodrich S, Howard M, Harmsen A, Randall TD, Lund FE. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat Med. 2001 Nov; 7(11):1209-16. PMID: 11689885.
      View in: PubMed
    16. Cakir-Kiefer C, Muller-Steffner H, Oppenheimer N, Schuber F. Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling. Biochem J. 2001 Sep 1; 358(Pt 2):399-406. PMID: 11513738; PMCID: PMC1222072.
    17. Oppenheimer N, Henehan GT, Huete-Pérez JA, Ito K. P. putida formaldehyde dehydrogenase. An alcohol dehydrogenase masquerading as an aldehyde dehydrogenase. Adv Exp Med Biol. 1997; 414:417-23. PMID: 9059646.
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    18. Buckley N, Maltby D, Burlingame AL, Oppenheimer N. Reactions of Charged Substrates. 4. The Gas-Phase Dissociation of (4-Substituted benzyl)dimethylsulfoniums and -pyridiniums. J Org Chem. 1996 Apr 19; 61(8):2753-2762. PMID: 11667109.
      View in: PubMed
    19. Henehan GT, Chang SH, Oppenheimer N. Aldehyde dehydrogenase activity of Drosophila melanogaster alcohol dehydrogenase: burst kinetics at high pH and aldehyde dismutase activity at physiological pH. Biochemistry. 1995 Sep 26; 34(38):12294-301. PMID: 7547972.
      View in: PubMed
    20. Oppenheimer N, Henehan GT. Horse liver alcohol dehydrogenase-catalyzed aldehyde oxidation. The sequential oxidation of alcohols to carboxylic acids under NADH recycling conditions. Adv Exp Med Biol. 1995; 372:407-15. PMID: 7484404.
      View in: PubMed
    21. Muller-Steffner H, Muzard M, Oppenheimer N, Schuber F. Mechanistic implications of cyclic ADP-ribose hydrolysis and methanolysis catalyzed by calf spleen NAD+glycohydrolase. Biochem Biophys Res Commun. 1994 Nov 15; 204(3):1279-85. PMID: 7980606.
      View in: PubMed
    22. Oppenheimer N. NAD hydrolysis: chemical and enzymatic mechanisms. Mol Cell Biochem. 1994 Sep; 138(1-2):245-51. PMID: 7898470.
      View in: PubMed
    23. Henehan GT, Oppenheimer N. Horse liver alcohol dehydrogenase-catalyzed oxidation of aldehydes: dismutation precedes net production of reduced nicotinamide adenine dinucleotide. Biochemistry. 1993 Jan 26; 32(3):735-8. PMID: 8422379.
      View in: PubMed
    24. Henehan GT, Kenyon GL, Oppenheimer N. The oxidation of aldehydes by horse liver alcohol dehydrogenase. Adv Exp Med Biol. 1993; 328:481-91. PMID: 8493927.
      View in: PubMed
    25. McDonald LJ, Wainschel LA, Oppenheimer N, Moss J. Amino acid-specific ADP-ribosylation: structural characterization and chemical differentiation of ADP-ribose-cysteine adducts formed nonenzymatically and in a pertussis toxin-catalyzed reaction. Biochemistry. 1992 Dec 1; 31(47):11881-7. PMID: 1445918.
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    26. Muller-Steffner HM, Malver O, Hosie L, Oppenheimer N, Schuber F. Slow-binding inhibition of NAD+ glycohydrolase by arabino analogues of beta-NAD. J Biol Chem. 1992 May 15; 267(14):9606-11. PMID: 1315761.
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    27. Handlon AL, Oppenheimer N. Thiol reduction of 3'-azidothymidine to 3'-aminothymidine: kinetics and biomedical implications. Pharm Res. 1988 May; 5(5):297-9. PMID: 3244639.
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    28. Keller TJ, Oppenheimer N. Enhanced bleomycin-mediated damage of DNA opposite charged nicks. A model for bleomycin-directed double strand scission of DNA. J Biol Chem. 1987 Nov 5; 262(31):15144-50. PMID: 2444595.
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    29. Kam BL, Malver O, Marschner TM, Oppenheimer N. Pyridine coenzyme analogues. Synthesis and characterization of alpha- and beta-nicotinamide arabinoside adenine dinucleotides. Biochemistry. 1987 Jun 16; 26(12):3453-61. PMID: 3307908.
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    30. Ehrenfeld GM, Shipley JB, Heimbrook DC, Sugiyama H, Long EC, van Boom JH, van der Marel GA, Oppenheimer N, Hecht SM. Copper-dependent cleavage of DNA by bleomycin. Biochemistry. 1987 Feb 10; 26(3):931-42. PMID: 2436656.
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    31. Burgner JW, Oppenheimer N, Ray WJ. Remote nitrogen-15 isotope effects on addition of cyanide to NAD. Biochemistry. 1987 Jan 13; 26(1):91-6. PMID: 3828311.
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    32. Moss J, Oppenheimer N, West RE, Stanley SJ. Amino acid specific ADP-ribosylation: substrate specificity of an ADP-ribosylarginine hydrolase from turkey erythrocytes. Biochemistry. 1986 Sep 23; 25(19):5408-14. PMID: 3778868.
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    33. Oppenheimer N. The stereospecificity of oxidation of alpha-[4R-2H]NADH by dehydrogenases. J Biol Chem. 1986 Sep 15; 261(26):12209-12. PMID: 2943736.
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    34. Kosen PA, Scheek RM, Naderi H, Basus VJ, Manogaran S, Schmidt PG, Oppenheimer N, Kuntz ID. Two-dimensional 1H NMR of three spin-labeled derivatives of bovine pancreatic trypsin inhibitor. Biochemistry. 1986 May 6; 25(9):2356-64. PMID: 2424497.
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    35. Carroll SF, McCloskey JA, Crain PF, Oppenheimer N, Marschner TM, Collier RJ. Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7237-41. PMID: 3864158; PMCID: PMC390824.
    36. Ehrenfeld GM, Rodriguez LO, Hecht SM, Chang C, Basus VJ, Oppenheimer N. Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission. Biochemistry. 1985 Jan 1; 24(1):81-92. PMID: 2581602.
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    37. Oppenheimer N. ADP-ribosylarginine. Methods Enzymol. 1984; 106:399-403. PMID: 6436643.
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    38. Barr PJ, Oppenheimer N, Santi DV. Thymidylate synthetase-catalyzed conversions of E-5-(2-bromovinyl)-2'-deoxyuridylate. J Biol Chem. 1983 Nov 25; 258(22):13627-31. PMID: 6417131.
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    39. Oppenheimer N, Bodley JW. Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2. J Biol Chem. 1981 Aug 25; 256(16):8579-81. PMID: 6267047.
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    40. Eberhard A, Burlingame AL, Eberhard C, Kenyon GL, Nealson KH, Oppenheimer N. Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry. 1981 Apr 28; 20(9):2444-9. PMID: 7236614.
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    41. Cook PF, Oppenheimer N, Cleland WW. Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase. Biochemistry. 1981 Mar 31; 20(7):1817-25. PMID: 7013802.
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    42. Oppenheimer N, Rodriguez LO, Hecht SM. Metal binding to modified bleomycins. Zinc and ferrous complexes with an acetylated bleomycin. Biochemistry. 1980 Aug 19; 19(17):4096-103. PMID: 6157406.
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    43. Moss J, Stanley SJ, Oppenheimer N. Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes. J Biol Chem. 1979 Sep 25; 254(18):8891-4. PMID: 225315.
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    44. Oppenheimer N, Rodriguez LO, Hecht SM. Proton nuclear magnetic resonance study of the structure of bleomycin and the zinc-bleomycin complex. Biochemistry. 1979 Aug 7; 18(16):3439-45. PMID: 89866.
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    45. Moss J, Garrison S, Oppenheimer N, Richardson SH. NAD-dependent ADP-ribosylation of arginine and proteins by Escherichia coli heat-labile enterotoxin. J Biol Chem. 1979 Jul 25; 254(14):6270-2. PMID: 221495.
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    46. Arnold LJ, Oppenheimer N, Lee CY, Kaplan NO. Proton nuclear magnetic resonance study of the conformation and configuration of the cyclized pyridine nucleotide adducts. Biochemistry. 1979 Jun 26; 18(13):2787-93. PMID: 224903.
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    47. Oppenheimer N. The stereospecificity of pig brain NAD-glycohydrolase-catalyzed methanolysis of NAD. FEBS Lett. 1978 Oct 15; 94(2):368-70. PMID: 212323.
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    48. Oppenheimer N. Structural determination and stereospecificity of the choleragen-catalyzed reaction of NAD+ with guanidines. J Biol Chem. 1978 Jul 25; 253(14):4907-10. PMID: 209022.
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    49. Oppenheimer N, Arnold LJ, Kaplan NO. Stereospecificity of the intramolecular association of reduced pyridine coenzymes. Biochemistry. 1978 Jun 27; 17(13):2613-9. PMID: 28147.
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    50. Oppenheimer N, Kaplan NO. Proton magnetic resonance study of the intramolecular association and conformation of the alpha and beta pyridine mononucleotides and nucleosides. Biochemistry. 1976 Sep 7; 15(18):3981-9. PMID: 963016.
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    51. Kasai H, Oashi Z, Harada F, Nishimura S, Oppenheimer N, Crain PF, Liehr JG, von Minden DL, McCloskey JA. Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Biochemistry. 1975 Sep 23; 14(19):4198-208. PMID: 1101947.
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    52. Oppenheimer N, Kaplan NO. The alpha beta epimerization of reduced nicotinamide adenine dinucleotide. Arch Biochem Biophys. 1975 Feb; 166(2):526-35. PMID: 164151.
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    53. Oppenheimer N, Kaplan NO. Glyceraldehyde-3-phosphate dehydrogenase catalyzed hydration of the 5-6 double bond of reduced beta-nicotinamide adenine dinucleotide (betaNADH). Formation of beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide. Biochemistry. 1974 Nov 5; 13(23):4685-94. PMID: 4371815.
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    54. Oppenheimer N, Kaplan NO. Structure of the primary acid rearrangement product of reduced nicotinamide adenine dinucleotide (NADH). Biochemistry. 1974 Nov 5; 13(23):4675-85. PMID: 4371814.
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    55. Lee CY, Oppenheimer N, Kaplan NO. Proton relaxation studies of diphosphopyridine coenzymes. Biochem Biophys Res Commun. 1974 Sep 23; 60(2):838-44. PMID: 4371396.
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    56. Oppenheimer N. The primary acid product of DPNH. Biochem Biophys Res Commun. 1973 Feb 5; 50(3):683-90. PMID: 4347526.
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    57. Oppenheimer N, Arnold LJ, Kaplan NO. A structure of pyridine nucleotides in solution. Proc Natl Acad Sci U S A. 1971 Dec; 68(12):3200-5. PMID: 4332014; PMCID: PMC389621.
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