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Eric Verdin, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-4808
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms of HIV Latency
    NIH/NIDA R01DA041742Apr 15, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Novel model for HIV Latency in Oral Primary Lymphoid Tissues
    NIH/NIDCR R01DE026010Apr 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Lysine Malonylation and SIRT5 in Epigenetic Regulation
    NIH/NIA R21AG051111Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    Identification of HIV latency biomarkers with a dual fluorescence reporter HIV
    NIH/NIAID R01AI117864Mar 1, 2015 - Feb 28, 2020
    Role: Principal Investigator
    Martin Delaney Collaboratory to Eradicate HIV-1 Infection
    NIH U19AI096113Jul 8, 2011 - Jun 30, 2016
    Role: Co-Investigator
    Novel Model for HIV Latency in Primary Memory T Cells
    NIH/NIDA DP1DA031126Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Epigenetic regulation of HIV latency
    NIH/NIDA R01DA030216Jul 1, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Reversible Mitochondrial Protein Acetylation and Metabolic Regulation
    NIH/NIDDK R24DK085610Jun 1, 2010 - May 31, 2020
    Role: Principal Investigator
    Role of HDAC7 in T-cell Development
    NIH/NIAID R56AI076664Mar 1, 2010 - Feb 28, 2012
    Role: Principal Investigator
    Regulation of HIV transcription and replication by SDF-1gamma
    NIH/NIAID R21AI065255Jul 1, 2005 - Jun 30, 2007
    Role: Principal Investigator
    Molecular Mechanisms of HIV Post-Integration Latency
    NIH/NIAID P01AI058708Sep 30, 2004 - Jan 31, 2010
    Role: Principal Investigator
    A New In Vitro Model for HIV Latency
    NIH/NIAID R21AI054141Jun 1, 2003 - May 31, 2005
    Role: Principal Investigator
    STRUCTURE-BASED DESIGN PARADIGM:HIV Tat.PCAF INHIBITORS
    NIH P01GM066531Aug 10, 2002 - Jul 31, 2010
    Role: Co-Investigator
    MODULATION OF CD8 T CELL FUNCTION BY HIV ENVELOPE PROTEI
    NIH/NHLBI R01HL063646Aug 16, 1999 - Jul 31, 2004
    Role: Principal Investigator
    MODULATION OF T CELL FUNCTIONS BY HIV1 TAT
    NIH/NIAID R01AI040847Sep 1, 1997 - Aug 31, 2003
    Role: Principal Investigator
    Role of Chromatin in HIV Transcriptional Regulation
    NIH/NIGMS R01GM051671May 1, 1995 - Nov 30, 2012
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sémétey O, Gaudin J, Danet JL, Salar P, Theil S, Fontaine M, Krausz M, Chaisse E, Eveillard S, Verdin E, Foissac X. Lavender decline in France is associated with chronic infection by lavender-specific strain of "Candidatus Phytoplasma solani." Appl Environ Microbiol. 2018 Oct 05. PMID: 30291116.
      View in: PubMed
    2. Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P. Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Cell Metab. 2018 Aug 21. PMID: 30146486.
      View in: PubMed
    3. Massart S, Chiumenti M, De Jonghe K, Glover R, Haegeman A, Koloniuk I, Komínek P, Kreuze J, Kutnjak D, Lotos L, Maclot F, Maliogka VI, Maree H, Olivier T, Olmos A, Pooggin M, Reynard JS, Ruiz-García AB, Safarova D, Schneeberger PH, Sela N, Turco S, Vainio EJ, Varallyai E, Verdin E, Westenberg M, Brostaux Y, Candresse T. Virus detection by high-throughput sequencing of small RNAs: large scale performance testing of sequence analysis strategies. Phytopathology. 2018 Aug 02. PMID: 30070618.
      View in: PubMed
    4. Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, Lichterfeld M. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells. Immunity. 2018 May 15. PMID: 29802019.
      View in: PubMed
    5. Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Tojal Da Silva I, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T Cells. Elife. 2018 May 01; 7. PMID: 29714165.
      View in: PubMed
    6. Kasler HG, Lee IS, Lim HW, Verdin E. Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells. Elife. 2018 Apr 17; 7. PMID: 29664401.
      View in: PubMed
    7. Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism. Am J Physiol Endocrinol Metab. 2018 Apr 10. PMID: 29634313.
      View in: PubMed
    8. Carrico C, Meyer JG, He W, Gibson BW, Verdin E. The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications. Cell Metab. 2018 Mar 06; 27(3):497-512. PMID: 29514063.
      View in: PubMed
    9. Ali I, Conrad RJ, Verdin E, Ott M. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev. 2018 Feb 14; 118(3):1216-1252. PMID: 29405707.
      View in: PubMed
    10. Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7):1564-1569. PMID: 29378963.
      View in: PubMed
    11. Shrimp JH, Garlick JM, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL. Defining Metabolic and Nonmetabolic Regulation of Histone Acetylation by NSAID Chemotypes. Mol Pharm. 2018 Mar 05; 15(3):729-736. PMID: 29240439.
      View in: PubMed
    12. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 Jan 02; 215(1):51-62. PMID: 29191913.
      View in: PubMed
    13. Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metab. 2017 Sep 05; 26(3):523-538.e5. PMID: 28877456.
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    14. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8. PMID: 28877458.
      View in: PubMed
    15. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. PMID: 28911171.
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    16. Newman JC, Verdin E. ß-Hydroxybutyrate: A Signaling Metabolite. Annu Rev Nutr. 2017 08 21; 37:51-76. PMID: 28826372.
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    17. Ramachandran D, Clara R, Fedele S, Hu J, Lackzo E, Huang JY, Verdin E, Langhans W, Mansouri A. Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight. Mol Metab. 2017 Oct; 6(10):1264-1273. PMID: 29031725.
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    18. Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free Radic Biol Med. 2017 Sep; 110:176-187. PMID: 28603085.
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    19. Verdin E, Wipf-Scheibel C, Gognalons P, Aller F, Jacquemond M, Tepfer M. Sequencing viral siRNAs to identify previously undescribed viruses and viroids in a panel of ornamental plant samples structured as a matrix of pools. Virus Res. 2017 09 15; 241:19-28. PMID: 28576697.
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    20. Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571. PMID: 28538176.
      View in: PubMed
    21. Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31; 4(2):147-156. PMID: 28447069.
      View in: PubMed
    22. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. PMID: 27978436.
      View in: PubMed
    23. Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L68-L78. PMID: 27815257.
      View in: PubMed
    24. Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM. Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol. 2016 08; 68(8):1887-98. PMID: 26866626.
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    25. Desbiez C, Verdin E, Tepfer M, Wipf-Scheibel C, Millot P, Dafalla G, Lecoq H. Characterization of a new cucurbit-infecting ipomovirus from Sudan. Arch Virol. 2016 Oct; 161(10):2913-5. PMID: 27430562.
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    26. Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5. PMID: 27244239.
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    27. Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. EBioMedicine. 2016 Jun; 8:248-264. PMID: 27428435; PMCID: PMC4919729.
    28. Tepfer M, Girardot G, Fénéant L, Ben Tamarzizt H, Verdin E, Moury B, Jacquemond M. A genetically novel, narrow-host-range isolate of cucumber mosaic virus (CMV) from rosemary. Arch Virol. 2016 Jul; 161(7):2013-7. PMID: 27138549.
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    29. Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila YL. A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res. 2016 Jan; 36(1):49-60. PMID: 26722027.
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    30. Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, Gupta MP. SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3ß. Mol Cell Biol. 2015 Dec 14; 36(5):678-92. PMID: 26667039; PMCID: PMC4760222.
    31. Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 2016 Feb 09; 23(2):303-14. PMID: 26686024; PMCID: PMC4749409 [Available on 02/09/17].
    32. Verdin E. NAD? in aging, metabolism, and neurodegeneration. Science. 2015 Dec 04; 350(6265):1208-13. PMID: 26785480.
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    33. Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Correction: Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency. PLoS Biol. 2015 Nov; 13(11):e1002302. PMID: 26569493; PMCID: PMC4646685.
    34. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. PMID: 26390242.
      View in: PubMed
    35. Nishida Y, Rardin MJ, Carrico C, He W, Sahu AK, Gut P, Najjar R, Fitch M, Hellerstein M, Gibson BW, Verdin E. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Mol Cell. 2015 Jul 16; 59(2):321-32. PMID: 26073543; PMCID: PMC4571487.
    36. Chavez L, Calvanese V, Verdin E. HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. PLoS Pathog. 2015 Jun; 11(6):e1004955. PMID: 26067822; PMCID: PMC4466167.
    37. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 Jun 01; 212(6):973. PMID: 25987725; PMCID: PMC4451124.
    38. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. PMID: 25918343; PMCID: PMC4419343.
    39. Ruelas DS, Chan JK, Oh E, Heidersbach AJ, Hebbeler AM, Chavez L, Verdin E, Rape M, Greene WC. MicroRNA-155 Reinforces HIV Latency. J Biol Chem. 2015 May 29; 290(22):13736-48. PMID: 25873391; PMCID: PMC4447952.
    40. Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. PLoS One. 2015; 10(3):e0122297. PMID: 25811481.
      View in: PubMed
    41. Dahabieh MS, Battivelli E, Verdin E. Understanding HIV latency: the road to an HIV cure. Annu Rev Med. 2015; 66:407-21. PMID: 25587657; PMCID: PMC4381961.
    42. Verdin E, Ott M. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64. PMID: 25549891.
      View in: PubMed
    43. Brown KD, Maqsood S, Huang JY, Pan Y, Harkcom W, Li W, Sauve A, Verdin E, Jaffrey SR. Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss. Cell Metab. 2014 Dec 02; 20(6):1059-68. PMID: 25470550; PMCID: PMC4940130.
    44. Newman JC, Verdin E. ß-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract. 2014 Nov; 106(2):173-81. PMID: 25193333; PMCID: PMC4414487.
    45. Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug; 15(8):536-50. PMID: 25053359.
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    46. Svanella-Dumas L, Verdin E, Faure C, German-Retana S, Gognalons P, Danet JL, Marais A, Candresse T. Adaptation of lettuce mosaic virus to Catharanthus roseus involves mutations in the central domain of the VPg. Mol Plant Microbe Interact. 2014 May; 27(5):491-7. PMID: 24400938.
      View in: PubMed
    47. Manson McManamy ME, Hakre S, Verdin EM, Margolis DM. Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors. Antivir Chem Chemother. 2014 Jan 29; 23(4):145-9. PMID: 24318952; PMCID: PMC3947511.
    48. Colin L, Verdin E, Van Lint C. HIV-1 chromatin, transcription, and the regulatory protein Tat. Methods Mol Biol. 2014; 1087:85-101. PMID: 24158816.
      View in: PubMed
    49. Verdin E. The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan. Nat Med. 2014 Jan; 20(1):25-7. PMID: 24398962.
      View in: PubMed
    50. Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013; 9(12):e1003834. PMID: 24385908; PMCID: PMC3873446.
    51. Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 03; 18(6):920-33. PMID: 24315375; PMCID: PMC4105152.
    52. Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013 Nov; 5(11):835-49. PMID: 24296486; PMCID: PMC3868726.
    53. Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 2013 Oct 24; 502(7472):489-98. PMID: 24153302.
      View in: PubMed
    54. Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A. Reactivation of latent HIV-1 in central memory CD4? T cells through TLR-1/2 stimulation. Retrovirology. 2013 Oct 24; 10:119. PMID: 24156240; PMCID: PMC3826617.
    55. Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab. 2014 Jan; 25(1):42-52. PMID: 24140022.
      View in: PubMed
    56. Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem. 2013 Nov 22; 288(47):33837-47. PMID: 24121500; PMCID: PMC3837126.
    57. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. PMID: 24074592; PMCID: PMC4019006.
    58. Verdin E, Ott M. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell. 2013 Jul 25; 51(2):132-4. PMID: 23870140.
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    59. Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 2013 Oct; 62(10):3404-17. PMID: 23835326; PMCID: PMC3781465.
    60. Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MB, Qi H, Teijaro JR, Xiao C. MicroRNAs of the miR-17~92 family are critical regulators of T(FH) differentiation. Nat Immunol. 2013 Aug; 14(8):849-57. PMID: 23812097; PMCID: PMC3740954.
    61. Ott M, Verdin E. Three rules for HIV latency: location, location, and location. Cell Host Microbe. 2013 Jun 12; 13(6):625-6. PMID: 23768485; PMCID: PMC3998752.
    62. Gut P, Verdin E. Rejuvenating SIRT1 activators. Cell Metab. 2013 May 07; 17(5):635-7. PMID: 23663735.
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    63. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6601-6. PMID: 23576753; PMCID: PMC3631688.
    64. Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol. 2013 Jun; 21(6):277-85. PMID: 23517573; PMCID: PMC3685471.
    65. Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar; 4(3-4):164-71. PMID: 24020007; PMCID: PMC3764471.
    66. Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E. The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY). 2013 Mar; 5(3):144-50. PMID: 23474711; PMCID: PMC3629286.
    67. Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 2013 Nov; 13(6):705-20. PMID: 23438705; PMCID: PMC3744624.
    68. Sinclair D, Verdin E. The longevity of sirtuins. Cell Rep. 2012 Dec 27; 2(6):1473-4. PMID: 23273894.
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    69. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. PMID: 23223453; PMCID: PMC3735349.
    70. Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013 Feb; 9(2):97-104. PMID: 23201900; PMCID: PMC3552031.
    71. Weir HJ, Murray TK, Kehoe PG, Love S, Verdin EM, O'Neill MJ, Lane JD, Balthasar N. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One. 2012; 7(11):e48225. PMID: 23139766; PMCID: PMC3491018.
    72. Kasler HG, Lim HW, Mottet D, Collins AM, Lee IS, Verdin E. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance. EMBO J. 2012 Nov 28; 31(23):4453-65. PMID: 23103766; PMCID: PMC3512390.
    73. Newman JC, He W, Verdin E. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem. 2012 Dec 14; 287(51):42436-43. PMID: 23086951; PMCID: PMC3522244.
    74. Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Dec 13; 3(12):1050-3. PMID: 24900427; PMCID: PMC4025838.
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    76. Pan Y, Nishida Y, Wang M, Verdin E. Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology. 2012; 58(6):524-30. PMID: 22947849.
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    81. Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Curr Opin Immunol. 2012 Aug; 24(4):501-6. PMID: 22658763.
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    82. Ismail H, Mofarrahi M, Echavarria R, Harel S, Verdin E, Lim HW, Jin ZG, Sun J, Zeng H, Hussain SN. Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1707-16. PMID: 22628435; PMCID: PMC4183139.
    83. Hakre S, Chavez L, Shirakawa K, Verdin E. HIV latency: experimental systems and molecular models. FEMS Microbiol Rev. 2012 May; 36(3):706-16. PMID: 22372374; PMCID: PMC3563430.
    84. Schilling B, Rardin MJ, MacLean BX, Zawadzka AM, Frewen BE, Cusack MP, Sorensen DJ, Bereman MS, Jing E, Wu CC, Verdin E, Kahn CR, Maccoss MJ, Gibson BW. Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics. 2012 May; 11(5):202-14. PMID: 22454539; PMCID: PMC3418851.
    85. Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res. 2012 Mar 02; 11(3):1633-43. PMID: 22309199; PMCID: PMC3324946.
    86. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012 Mar 15; 188(6):2712-21. PMID: 22312127; PMCID: PMC3478122.
    87. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle. 2013 Feb 01; 12(3):452-62. PMID: 23255218; PMCID: PMC3587446.
    88. Gallastegui E, Marshall B, Vidal D, Sanchez-Duffhues G, Collado JA, Alvarez-Fernández C, Luque N, Terme JM, Gatell JM, Sánchez-Palomino S, Muñoz E, Mestres J, Verdin E, Jordan A. Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1. J Virol. 2012 Apr; 86(7):3795-808. PMID: 22258251; PMCID: PMC3302487.
    89. Moury B, Verdin E. Viruses of pepper crops in the Mediterranean basin: a remarkable stasis. Adv Virus Res. 2012; 84:127-62. PMID: 22682167.
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    90. Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27. PMID: 22291164; PMCID: PMC3292902.
    91. Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol. 2011 Nov; 9(11):e1001206. PMID: 22140357; PMCID: PMC3226458.
    92. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 06; 287(2):1090-9. PMID: 22084242; PMCID: PMC3256921.
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    94. Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012658. PMID: 21908771; PMCID: PMC3237090.
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    98. Kasler HG, Young BD, Mottet D, Lim HW, Collins AM, Olson EN, Verdin E. Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol. 2011 Apr 15; 186(8):4782-93. PMID: 21398603.
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    100. Tentchev D, Verdin E, Marchal C, Jacquet M, Aguilar JM, Moury B. Evolution and structure of Tomato spotted wilt virus populations: evidence of extensive reassortment and insights into emergence processes. J Gen Virol. 2011 Apr; 92(Pt 4):961-73. PMID: 21169211.
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    102. Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010 Dec 01; 12(6):662-7. PMID: 21109198.
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    105. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4. PMID: 20798296.
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    107. Trono D, Van Lint C, Rouzioux C, Verdin E, Barré-Sinoussi F, Chun TW, Chomont N. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science. 2010 Jul 09; 329(5988):174-80. PMID: 20616270.
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    109. Chávez L, Kauder S, Verdin E. In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods. 2011 Jan; 53(1):47-53. PMID: 20670606; PMCID: PMC3566233.
    110. Ott M, Verdin E. HAT trick: p300, small molecule, inhibitor. Chem Biol. 2010 May 28; 17(5):417-8. PMID: 20534339.
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    114. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. PMID: 20351400; PMCID: PMC2871240.
    115. Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe. 2010 Mar 18; 7(3):234-44. PMID: 20227666; PMCID: PMC2844784.
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    119. Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiguen A, Verdin E, Olive D, Van Lint C, Hejnar J, Hirsch I. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 2009 Aug; 5(8):e1000554. PMID: 19696893; PMCID: PMC2722084.
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    121. Cooper HM, Huang JY, Verdin E, Spelbrink JN. A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One. 2009; 4(3):e4986. PMID: 19333382; PMCID: PMC2659428.
    122. Saunders LR, Verdin E. Cell biology. Stress response and aging. Science. 2009 Feb 20; 323(5917):1021-2. PMID: 19229027.
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    135. Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007 Nov 16; 282(46):33583-92. PMID: 17715127.
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    137. Barrett A, Santangelo S, Tan K, Catchpole S, Roberts K, Spencer-Dene B, Hall D, Scibetta A, Burchell J, Verdin E, Freemont P, Taylor-Papadimitriou J. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer. 2007 Jul 15; 121(2):265-75. PMID: 17373667.
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    140. Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, Richard DJ, Forrest A, Spurdle A, Verdin E, Crossley M, Fanciulli M, Chenevix-Trench G, Young DB, Khanna KK. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem. 2007 May 18; 282(20):15248-57. PMID: 17379597.
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    142. Krennhrubec K, Marshall BL, Hedglin M, Verdin E, Ulrich SM. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15; 17(10):2874-8. PMID: 17346959.
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    143. Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S. Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Res. 2007 Feb 01; 67(3):1019-29. PMID: 17283134.
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    145. Saunders LR, Verdin E. Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. Mol Cancer Ther. 2006 Nov; 5(11):2777-85. PMID: 17121924.
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    149. Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 2006 Jan 11; 25(1):139-49. PMID: 16319923; PMCID: PMC1356344.
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    154. Waltregny D, Glénisson W, Tran SL, North BJ, Verdin E, Colige A, Castronovo V. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J. 2005 Jun; 19(8):966-8. PMID: 15772115.
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    162. Verdin E, Dequiedt F, Fischle W, Frye R, Marshall B, North B. Measurement of mammalian histone deacetylase activity. Methods Enzymol. 2004; 377:180-96. PMID: 14979025.
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    163. Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5. PMID: 15171254.
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    164. Heltweg B, Dequiedt F, Verdin E, Jung M. Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. Anal Biochem. 2003 Aug 01; 319(1):42-8. PMID: 12842105.
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    165. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell. 2003 Jul; 12(1):167-76. PMID: 12887902.
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    166. Danet JL, Foissac X, Zreik L, Salar P, Verdin E, Nourrisseau JG, Garnier M. "Candidatus Phlomobacter fragariae" Is the Prevalent Agent of Marginal Chlorosis of Strawberry in French Production Fields and Is Transmitted by the Planthopper Cixius wagneri (China). Phytopathology. 2003 Jun; 93(6):644-9. PMID: 18943049.
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    167. Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, Verdin E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 2003 May; 18(5):687-98. PMID: 12753745.
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    168. Verdin E, Dequiedt F, Kasler HG. Class II histone deacetylases: versatile regulators. Trends Genet. 2003 May; 19(5):286-93. PMID: 12711221.
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    169. Verdin E, Salar P, Danet JL, Choueiri E, Jreijiri F, El Zammar S, Gélie B, Bové JM, Garnier M. 'Candidatus phytoplasma phoenicium' sp. nov., a novel phytoplasma associated with an emerging lethal disease of almond trees in Lebanon and Iran. Int J Syst Evol Microbiol. 2003 May; 53(Pt 3):833-8. PMID: 12807209.
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    170. Jordan A, Bisgrove D, Verdin E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 2003 Apr 15; 22(8):1868-77. PMID: 12682019; PMCID: PMC154479.
    171. Pion M, Jordan A, Biancotto A, Dequiedt F, Gondois-Rey F, Rondeau S, Vigne R, Hejnar J, Verdin E, Hirsch I. Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. J Virol. 2003 Apr; 77(7):4025-32. PMID: 12634362; PMCID: PMC150653.
    172. North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell. 2003 Feb; 11(2):437-44. PMID: 12620231.
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    173. Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. PMID: 12186850; PMCID: PMC2174009.
    174. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J. 2002 Jun 03; 21(11):2715-23. PMID: 12032084; PMCID: PMC125383.
    175. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002 Mar; 9(3):575-86. PMID: 11931765.
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    176. Murphy JC, Fischle W, Verdin E, Sinclair JH. Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J. 2002 Mar 01; 21(5):1112-20. PMID: 11867539; PMCID: PMC125876.
    177. Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR, Denu JM. Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem. 2002 Apr 12; 277(15):12632-41. PMID: 11812793.
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    178. Deroanne CF, Bonjean K, Servotte S, Devy L, Colige A, Clausse N, Blacher S, Verdin E, Foidart JM, Nusgens BV, Castronovo V. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene. 2002 Jan 17; 21(3):427-36. PMID: 11821955.
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    179. Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002 Jan; 9(1):45-57. PMID: 11804585.
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