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Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A. bioRxiv. 2024 Sep 05.
Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM. PMID: 39282303; PMCID: PMC11398473.
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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid. bioRxiv. 2024 Aug 26.
Chen DF, Roe LT, Li Y, Borges AL, Zhang JY, Babbar P, Maji S, Stevens MGV, Correy GJ, Diolaiti ME, Smith DH, Ashworth A, Stroud RM, Kelly MJS, Bondy-Denomy J, Fraser JS. PMID: 39253479; PMCID: PMC11383003.
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Biochemical characterization of a high affinity phosphate transporter (PiPT) from root endophyte fungus Piriformospora indica. Protein Expr Purif. 2024 Nov; 223:106559.
Kumar H, Bajaj A, Kumar P, Aggarwal R, Chalia V, Pradhan RK, Yadav R, Sinha S, Agarwal V, Harries W, Dua M, Stroud RM, Johri AK. PMID: 39089400.
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PubMed Mentions: Fields:
Translation:
Animals
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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome. Nat Commun. 2024 Jun 25; 15(1):5388.
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F. PMID: 38918376; PMCID: PMC11199644.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica. bioRxiv. 2024 May 14.
Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM. PMID: 38798537; PMCID: PMC11118524.
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Kinetic network modeling with molecular simulation inputs: A proton-coupled phosphate symporter. Biophys J. 2024 Mar 28.
Liu Y, Li C, Gupta M, Stroud RM, Voth GA. PMID: 38549372.
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PubMed Mentions:
1 Fields:
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Structural basis of prostaglandin efflux by MRP4. Nat Struct Mol Biol. 2024 Apr; 31(4):621-632.
Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. PMID: 38216659; PMCID: PMC11145372.
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PubMed Mentions:
2 Fields:
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Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels. Elife. 2023 Nov 22; 12.
Lu J, Dreyer I, Dickinson MS, Panzer S, Jaslan D, Navarro-Retamal C, Geiger D, Terpitz U, Becker D, Stroud RM, Marten I, Hedrich R. PMID: 37991833; PMCID: PMC10665017.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Substrate recognition and proton coupling by a bacterial member of solute carrier family 17. J Biol Chem. 2023 05; 299(5):104646.
Batarni S, Nayak N, Chang A, Li F, Hareendranath S, Zhou L, Xu H, Stroud R, Eriksen J, Edwards RH. PMID: 36965620; PMCID: PMC10149257.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat Struct Mol Biol. 2023 03; 30(3):296-308.
Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36782050; PMCID: PMC10312659.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. bioRxiv. 2023 Jan 28.
Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36747776; PMCID: PMC9900942.
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022 12 07; 11.
Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, Tagliazucchi L, Moschella MG, Guerrini R, Pacifico S, Luciani R, Genovese F, Henrich S, Alboni S, Santarem N, da Silva Cordeiro A, Giovannetti E, Peters GJ, Pinton P, Rimessi A, Cruciani G, Stroud RM, Wade RC, Mangani S, Marverti G, D'Arca D, Ponterini G, Costi MP. PMID: 36475542; PMCID: PMC9831607.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Diversity of function and mechanism in a family of organic anion transporters. Curr Opin Struct Biol. 2022 08; 75:102399.
Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH. PMID: 35660266; PMCID: PMC9884543.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc Natl Acad Sci U S A. 2022 03 01; 119(9).
Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM. PMID: 35210362; PMCID: PMC8892357.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel. Biochemistry. 2022 10 18; 61(20):2177-2181.
Dickinson MS, Pourmal S, Gupta M, Bi M, Stroud RM. PMID: 34964607; PMCID: PMC9931035.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody. Biochemistry. 2021 08 17; 60(32):2463-2470.
Eriksen J, Li F, Stroud RM, Edwards RH. PMID: 34319067; PMCID: PMC8823281.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA. PMID: 34135124; PMCID: PMC8237618.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
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PubMed Mentions:
2
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
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PubMed Mentions:
4
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Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut. Proc Natl Acad Sci U S A. 2021 04 13; 118(15).
Vecchio AJ, Rathnayake SS, Stroud RM. PMID: 33876770; PMCID: PMC8053971.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry. 2021 Apr 27; 60(16):1243-1247.
Kholodar SA, Finer-Moore JS, Swiderek K, Arafet K, Moliner V, Stroud RM, Kohen A. PMID: 33829766; PMCID: PMC10627423.
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Cells
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Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. J Biol Chem. 2021 Jan-Jun; 296:100557.
Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM. PMID: 33744283; PMCID: PMC8102919.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife. 2020 11 25; 9.
Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS. PMID: 33236988; PMCID: PMC7785296.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521).
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, et al. PMID: 33060197; PMCID: PMC7808408.
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PubMed Mentions:
382 Fields:
Translation:
HumansCells
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Ion transport and regulation in a synaptic vesicle glutamate transporter. Science. 2020 05 22; 368(6493):893-897.
Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM. PMID: 32439795; PMCID: PMC7388591.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Diversity in kinetics correlated with structure in nano body-stabilized LacY. PLoS One. 2020; 15(5):e0232846.
Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. PMID: 32380514; PMCID: PMC7205474.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
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Resting state structure of the hyperdepolarization activated two-pore channel 3. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):1988-1993.
Dickinson MS, Myasnikov A, Eriksen J, Poweleit N, Stroud RM. PMID: 31924746; PMCID: PMC6995003.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17817-17824.
Vecchio AJ, Stroud RM. PMID: 31434788; PMCID: PMC6731655.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8.
Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896; PMCID: PMC6588346.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Structures suggest a mechanism for energy coupling by a family of organic anion transporters. PLoS Biol. 2019 05; 17(5):e3000260.
Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH. PMID: 31083648; PMCID: PMC6532931.
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PubMed Mentions:
25 Fields:
Translation:
Cells
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High-pressure, high-temperature molecular doping of nanodiamond. Sci Adv. 2019 May; 5(5):eaau6073.
Crane MJ, Petrone A, Beck RA, Lim MB, Zhou X, Li X, Stroud RM, Pauzauskie PJ. PMID: 31058218; PMCID: PMC6499550.
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PubMed Mentions:
12 Fields:
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High-Throughput Nano-Scale Characterization of Membrane Proteins Using Fluorescence-Detection Size-Exclusion Chromatography. Methods Mol Biol. 2019; 2025:361-388.
Vecchio AJ, Stroud RM. PMID: 31267462; PMCID: PMC6890415.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9095-E9104.
Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. PMID: 30190435; PMCID: PMC6166827.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18).
Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453; PMCID: PMC6138441.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):8769-8774.
Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. PMID: 30108145; PMCID: PMC6126719.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. Biochemistry. 2018 05 15; 57(19):2786-2795.
Finer-Moore JS, Lee TT, Stroud RM. PMID: 29717875; PMCID: PMC6242337.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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On the structure and mechanism of two-pore channels. FEBS J. 2018 01; 285(2):233-243.
Kintzer AF, Stroud RM. PMID: 28656706; PMCID: PMC5745306.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E438-E447.
Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Oliéric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM, Tampé R. PMID: 28069938; PMCID: PMC5278451.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure. 2016 11 01; 24(11):1936-1946.
Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A. PMID: 27692964; PMCID: PMC5093063.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10542-6.
Thurtle-Schmidt BH, Stroud RM. PMID: 27601653; PMCID: PMC5035872.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4711-6.
Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM. PMID: 27078104; PMCID: PMC4855560.
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PubMed Mentions:
95 Fields:
Translation:
HumansCells
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Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana. Nature. 2016 Mar 10; 531(7593):258-62.
Kintzer AF, Stroud RM. PMID: 26961658; PMCID: PMC4863712.
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PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
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Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies. Methods Mol Biol. 2016; 1432:203-21.
Chaudhary S, Saha S, Thamminana S, Stroud RM. PMID: 27485338; PMCID: PMC8367189.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Integral Membrane Protein Expression in Saccharomyces cerevisiae. Methods Mol Biol. 2016; 1432:163-86.
Boswell-Casteel RC, Johnson JM, Stroud RM, Hays FA. PMID: 27485336; PMCID: PMC6166409.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J Mol Biol. 2015 Dec 04; 427(24):3862-76.
Finer-Moore J, Czudnochowski N, O'Connell JD, Wang AL, Stroud RM. PMID: 26470919; PMCID: PMC4663122.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Fungal association and utilization of phosphate by plants: success, limitations, and future prospects. Front Microbiol. 2015; 6:984.
Johri AK, Oelmüller R, Dua M, Yadav V, Kumar M, Tuteja N, Varma A, Bonfante P, Persson BL, Stroud RM. PMID: 26528243; PMCID: PMC4608361.
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PubMed Mentions:
32
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Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9004-9.
Kumar H, Finer-Moore JS, Kaback HR, Stroud RM. PMID: 26157133; PMCID: PMC4517220.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell. 2015 Apr 23; 161(3):501-512.
Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS. PMID: 25865481; PMCID: PMC4409929.
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PubMed Mentions:
68 Fields:
Translation:
Cells
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Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J Med Chem. 2015 Apr 23; 58(8):3572-81.
Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. PMID: 25798950; PMCID: PMC4634673.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J Med Chem. 2015 Jan 22; 58(2):1012-8.
Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP. PMID: 25427005; PMCID: PMC8346289.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature. 2015 Jan 15; 517(7534):396-400.
Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. PMID: 25363761; PMCID: PMC4372080.
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PubMed Mentions:
62 Fields:
Translation:
Cells
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General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays. Curr Protoc Protein Sci. 2014 Aug 01; 77:29.11.1-29.11.14.
Tomasiak TM, Pedersen BP, Chaudhary S, Rodriguez A, Colmanares YR, Roe-Zurz Z, Thamminana S, Tessema M, Stroud RM. PMID: 25081745; PMCID: PMC4672949.
View in:
PubMed Mentions:
7 Fields:
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Tetra detector analysis of membrane proteins. Curr Protoc Protein Sci. 2014 Aug 01; 77:29.10.1-29.10.30.
Miercke LJW, Robbins RA, Stroud RM. PMID: 25081744; PMCID: PMC4178957.
View in:
PubMed Mentions:
3 Fields:
-
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3865-70.
Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. PMID: 24613931; PMCID: PMC3956205.
View in:
PubMed Mentions:
107 Fields:
Translation:
Cells
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Structure of sugar-bound LacY. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1784-8.
Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM. PMID: 24453216; PMCID: PMC3918835.
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PubMed Mentions:
65 Fields:
Translation:
Cells
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The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res. 2014 Feb; 42(3):2037-48.
Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM. PMID: 24214967; PMCID: PMC3919597.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18484-9.
Pak JE, Ekendé EN, Kifle EG, O'Connell JD, De Angelis F, Tessema MB, Derfoufi KM, Robles-Colmenares Y, Robbins RA, Goormaghtigh E, Vandenbussche G, Stroud RM. PMID: 24173033; PMCID: PMC3832018.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
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Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11; 56(13):5446-55.
Tochowicz A, Dalziel S, Eidam O, O'Connell JD, Griner S, Finer-Moore JS, Stroud RM. PMID: 23710599; PMCID: PMC3880649.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. J Mol Biol. 2013 Oct 23; 425(20):3875-87.
Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM. PMID: 23707380; PMCID: PMC3900414.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature. 2013 Jul 04; 499(7456):107-10.
Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, Risenmay AJ, Sali A, Stroud RM. PMID: 23685453; PMCID: PMC3702627.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc. 2013 May 22; 135(20):7583-92.
Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. PMID: 23611499; PMCID: PMC3674108.
View in:
PubMed Mentions:
14 Fields:
Translation:
Cells
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Crystal structure of a eukaryotic phosphate transporter. Nature. 2013 Apr 25; 496(7446):533-6.
Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, Schlessinger A, Bonomi M, Harries W, Sali A, Johri AK, Stroud RM. PMID: 23542591; PMCID: PMC3678552.
View in:
PubMed Mentions:
97 Fields:
Translation:
HumansAnimalsCells
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Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8.
Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. PMID: 23381628; PMCID: PMC3645303.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
-
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J Med Chem. 2012 Nov 26; 55(22):10272-6.
Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP. PMID: 23075414.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J Am Chem Soc. 2012 Oct 24; 134(42):17722-30.
Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A. PMID: 23034004; PMCID: PMC3490427.
View in:
PubMed Mentions:
29 Fields:
Translation:
Cells
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LpxI structures reveal how a lipid A precursor is synthesized. Nat Struct Mol Biol. 2012 Nov; 19(11):1132-8.
Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. PMID: 23042606; PMCID: PMC3562136.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. Acta Crystallogr D Biol Crystallogr. 2012 Sep; 68(Pt 9):1232-41.
Pozzi C, Ferrari S, Cortesi D, Luciani R, Stroud RM, Catalano A, Costi MP, Mangani S. PMID: 22948925; PMCID: PMC10316677.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol. 2012 Jul; 72(1):53-64.
Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS. PMID: 22807325; PMCID: PMC3405197.
View in:
PubMed Mentions:
169 Fields:
Translation:
HumansCells
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Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. PLoS One. 2012; 7(4):e34918.
Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F. PMID: 22529956; PMCID: PMC3329556.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92.
Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106; PMCID: PMC3322386.
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PubMed Mentions:
90 Fields:
Translation:
HumansCells
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Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells. Nat Protoc. 2012 Feb 09; 7(3):453-66.
Chaudhary S, Pak JE, Gruswitz F, Sharma V, Stroud RM. PMID: 22322218; PMCID: PMC3613139.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Rapid identification of recombinant Fabs that bind to membrane proteins. Methods. 2011 Dec; 55(4):303-9.
Kim J, Stroud RM, Craik CS. PMID: 21958987; PMCID: PMC3264787.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells. Methods. 2011 Dec; 55(4):273-80.
Chaudhary S, Pak JE, Pedersen BP, Bang LJ, Zhang LB, Ngaw SM, Green RG, Sharma V, Stroud RM. PMID: 21925269; PMCID: PMC3600976.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Membranes. Curr Opin Struct Biol. 2011 Aug; 21(4):495-6.
Stroud RM, Schertler GF. PMID: 21875531.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13450-5.
Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS. PMID: 21795602; PMCID: PMC3158157.
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PubMed Mentions:
18 Fields:
Translation:
Cells
-
Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 06; 9:47.
Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729333; PMCID: PMC3149027.
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PubMed Mentions:
48 Fields:
Translation:
Cells
-
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 06; 9:48.
Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729334; PMCID: PMC3158555.
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PubMed Mentions:
37 Fields:
Translation:
Cells
-
New tools in membrane protein determination. F1000 Biol Rep. 2011; 3:8.
Stroud RM. PMID: 21655333; PMCID: PMC3100781.
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PubMed Mentions:
9
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Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. PLoS One. 2010 Nov 30; 5(11):e15050.
Nelson PA, Khodadoust M, Prodhomme T, Spencer C, Patarroyo JC, Varrin-Doyer M, Ho JD, Stroud RM, Zamvil SS. PMID: 21151500; PMCID: PMC2994828.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Structural context shapes the aquaporin selectivity filter. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17164-9.
Savage DF, O'Connell JD, Miercke LJ, Finer-Moore J, Stroud RM. PMID: 20855585; PMCID: PMC2951435.
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PubMed Mentions:
34 Fields:
Translation:
Cells
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Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17182-7.
Egea PF, Stroud RM. PMID: 20855604; PMCID: PMC2951439.
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PubMed Mentions:
94 Fields:
Translation:
Cells
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Unlocking the eukaryotic membrane protein structural proteome. Curr Opin Struct Biol. 2010 Aug; 20(4):464-70.
Lee JK, Stroud RM. PMID: 20739007; PMCID: PMC3530418.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11038-43.
De Angelis F, Lee JK, O'Connell JD, Miercke LJ, Verschueren KH, Srinivasan V, Bauvois C, Govaerts C, Robbins RA, Ruysschaert JM, Stroud RM, Vandenbussche G. PMID: 20534468; PMCID: PMC2890744.
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PubMed Mentions:
38 Fields:
Translation:
Cells
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Function of human Rh based on structure of RhCG at 2.1 A. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9638-43.
Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM. PMID: 20457942; PMCID: PMC2906887.
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PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Overexpression and purification of integral membrane proteins in yeast. Methods Enzymol. 2010; 470:695-707.
Hays FA, Roe-Zurz Z, Stroud RM. PMID: 20946832.
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PubMed Mentions:
18 Fields:
Translation:
Animals
-
Comparison of human solute carriers. Protein Sci. 2010 Mar; 19(3):412-28.
Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. PMID: 20052679; PMCID: PMC2866268.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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A survey of integral alpha-helical membrane proteins. J Struct Funct Genomics. 2009 Dec; 10(4):269-80.
Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. PMID: 19760129; PMCID: PMC2780624.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8192-7.
Alian A, Griner SL, Chiang V, Tsiang M, Jones G, Birkus G, Geleziunas R, Leavitt AD, Stroud RM. PMID: 19416821; PMCID: PMC2688900.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7437-42.
Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM. PMID: 19383790; PMCID: PMC2678640.
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PubMed Mentions:
159 Fields:
Translation:
HumansCells
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Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J Mol Biol. 2009 May 15; 388(4):785-800.
Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM. PMID: 19298824; PMCID: PMC2796871.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. J Struct Funct Genomics. 2009 Apr; 10(2):193-208.
Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W. PMID: 19148774; PMCID: PMC2705707.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nat Protoc. 2009; 4(5):619-37.
Newby ZE, O'Connell JD, Gruswitz F, Hays FA, Harries WE, Harwood IM, Ho JD, Lee JK, Savage DF, Miercke LJ, Stroud RM. PMID: 19360018; PMCID: PMC4075773.
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PubMed Mentions:
40 Fields:
Translation:
Cells
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The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 05; 457(7230):687-93.
Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. PMID: 19079236; PMCID: PMC2846394.
View in:
PubMed Mentions:
349 Fields:
Translation:
AnimalsCells
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Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. J Mol Biol. 2009 Jan 23; 385(3):820-30.
Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM. PMID: 19061901; PMCID: PMC2659619.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination. J Struct Funct Genomics. 2009 Mar; 10(1):9-16.
Hays FA, Roe-Zurz Z, Li M, Kelly L, Gruswitz F, Sali A, Stroud RM. PMID: 19031011; PMCID: PMC2756966.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. PLoS One. 2008; 3(11):e3619.
Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM. PMID: 18978942; PMCID: PMC2572998.
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PubMed Mentions:
11 Fields:
Translation:
Cells
-
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. PLoS One. 2008; 3(10):e3528.
Egea PF, Napetschnig J, Walter P, Stroud RM. PMID: 18953414; PMCID: PMC2568955.
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PubMed Mentions:
14 Fields:
Translation:
Cells
-
Michael A. Raftery (1936-2007)--the first enzyme mechanism, sequential cooperativity, and the nicotinic acetylcholine receptor defined. Protein Sci. 2008 Oct; 17(10):1864-6.
Stroud RM. PMID: 18819191; PMCID: PMC2548366.
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PubMed Mentions: Fields:
-
Crystal structure of bovine mitochondrial factor B at 0.96-A resolution. Proc Natl Acad Sci U S A. 2008 Sep 09; 105(36):13379-84.
Lee JK, Belogrudov GI, Stroud RM. PMID: 18768789; PMCID: PMC2528870.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol. 2008 Jun; 15(6):619-25.
Newby ZE, O'Connell J, Robles-Colmenares Y, Khademi S, Miercke LJ, Stroud RM. PMID: 18500352; PMCID: PMC2568999.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6876-81.
Alian A, Lee TT, Griner SL, Stroud RM, Finer-Moore J. PMID: 18451029; PMCID: PMC2383949.
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PubMed Mentions:
52 Fields:
Translation:
Cells
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Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2391-6.
Du Z, Lee JK, Tjhen R, Stroud RM, James TL. PMID: 18268334; PMCID: PMC2268147.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science. 2007 Nov 02; 318(5851):815-7.
Menuz K, Stroud RM, Nicoll RA, Hays FA. PMID: 17975069.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
-
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. PLoS One. 2007 Jul 11; 2(7):e607.
Reyes CL, Rutenber E, Walter P, Stroud RM. PMID: 17622352; PMCID: PMC1904258.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. RNA. 2007 Jul; 13(7):1043-51.
Du Z, Lee JK, Fenn S, Tjhen R, Stroud RM, James TL. PMID: 17526645; PMCID: PMC1894928.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Cell-free complements in vivo expression of the E. coli membrane proteome. Protein Sci. 2007 May; 16(5):966-76.
Savage DF, Anderson CL, Robles-Colmenares Y, Newby ZE, Stroud RM. PMID: 17456747; PMCID: PMC2206641.
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PubMed Mentions:
19 Fields:
Translation:
Cells
-
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Mol Cell. 2007 Apr 27; 26(2):189-203.
Hur S, Stroud RM. PMID: 17466622; PMCID: PMC3562137.
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PubMed Mentions:
49 Fields:
Translation:
Cells
-
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution. Nucleic Acids Res. 2007; 35(8):2651-60.
Fenn S, Du Z, Lee JK, Tjhen R, Stroud RM, James TL. PMID: 17426136; PMCID: PMC1885661.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Structural basis of aquaporin inhibition by mercury. J Mol Biol. 2007 May 04; 368(3):607-17.
Savage DF, Stroud RM. PMID: 17376483; PMCID: PMC3535476.
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PubMed Mentions:
48 Fields:
Translation:
Cells
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The crystal structure of E. coli rRNA pseudouridine synthase RluE. J Mol Biol. 2007 Apr 13; 367(5):1459-70.
Pan H, Ho JD, Stroud RM, Finer-Moore J. PMID: 17320904; PMCID: PMC1876706.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Transmembrane transporters: an open and closed case. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1445-6.
Stroud RM. PMID: 17251354; PMCID: PMC1785277.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):42-7.
Gruswitz F, O'Connell J, Stroud RM. PMID: 17190799; PMCID: PMC1765473.
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PubMed Mentions:
63 Fields:
Translation:
Cells
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The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction. Physiology (Bethesda). 2006 Dec; 21:419-29.
Khademi S, Stroud RM. PMID: 17119155.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem. 2006 Dec 22; 281(51):38969-73.
Hur S, Stroud RM, Finer-Moore J. PMID: 17085441.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem. 2006 Oct 19; 49(21):6308-23.
He X, Alian A, Stroud R, Ortiz de Montellano PR. PMID: 17034137; PMCID: PMC2517584.
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PubMed Mentions:
54 Fields:
Translation:
Cells
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The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20; 45(24):7415-28.
Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. PMID: 16768437; PMCID: PMC2556892.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure. 2006 Apr; 14(4):737-48.
Keatinge-Clay AT, Stroud RM. PMID: 16564177.
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PubMed Mentions:
95 Fields:
Translation:
Cells
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On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84.
Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. PMID: 16365312; PMCID: PMC1316886.
View in:
PubMed Mentions:
260 Fields:
Translation:
HumansAnimalsCells
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Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18932-7.
Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM. PMID: 16361443; PMCID: PMC1323191.
View in:
PubMed Mentions:
66 Fields:
Translation:
Cells
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The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct; 61(Pt 10):1320-34.
Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. PMID: 16204883.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A. J Biol Chem. 2005 Nov 18; 280(46):38823-30.
Du Z, Lee JK, Tjhen R, Li S, Pan H, Stroud RM, James TL. PMID: 16186123.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol. 2005 Apr; 15(2):213-20.
Egea PF, Stroud RM, Walter P. PMID: 15837181.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansAnimalsCells
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A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Cell. 2005 Mar 11; 120(5):599-611.
Lee TT, Agarwalla S, Stroud RM. PMID: 15766524.
View in:
PubMed Mentions:
52 Fields:
Translation:
Cells
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De novo design of an IL-4 antagonist and its structure at 1.9 A. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):1889-94.
Laporte SL, Forsyth CM, Cunningham BC, Miercke LJ, Akhavan D, Stroud RM. PMID: 15684085; PMCID: PMC548554.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
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Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16454-9.
Chu F, Shan SO, Moustakas DT, Alber F, Egea PF, Stroud RM, Walter P, Burlingame AL. PMID: 15546976; PMCID: PMC528904.
View in:
PubMed Mentions:
36 Fields:
Translation:
Cells
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Mechanism of association and reciprocal activation of two GTPases. PLoS Biol. 2004 Oct; 2(10):e320.
Shan SO, Stroud RM, Walter P. PMID: 15383838; PMCID: PMC517823.
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PubMed Mentions:
58 Fields:
Translation:
Cells
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The channel architecture of aquaporin 0 at a 2.2-A resolution. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14045-50.
Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM. PMID: 15377788; PMCID: PMC521118.
View in:
PubMed Mentions:
123 Fields:
Translation:
AnimalsCells
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Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science. 2004 Sep 10; 305(5690):1587-94.
Khademi S, O'Connell J, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM. PMID: 15361618.
View in:
PubMed Mentions:
252 Fields:
Translation:
Cells
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An antibiotic factory caught in action. Nat Struct Mol Biol. 2004 Sep; 11(9):888-93.
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. PMID: 15286722.
View in:
PubMed Mentions:
53 Fields:
Translation:
Cells
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Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies. J Biol Chem. 2004 Aug 13; 279(33):34123-9.
Agarwalla S, Stroud RM, Gaffney BJ. PMID: 15181002; PMCID: PMC1237038.
View in:
PubMed Mentions:
22 Fields:
Translation:
Cells
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Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE. 2004 Apr 28; 2004(231):re7.
Stroud RM, Wells JA. PMID: 15126678.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Structure. 2004 Mar; 12(3):397-407.
Lee TT, Agarwalla S, Stroud RM. PMID: 15016356.
View in:
PubMed Mentions:
21 Fields:
Translation:
Cells
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Substrate twinning activates the signal recognition particle and its receptor. Nature. 2004 Jan 15; 427(6971):215-21.
Egea PF, Shan SO, Napetschnig J, Savage DF, Walter P, Stroud RM. PMID: 14724630.
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PubMed Mentions:
137 Fields:
Translation:
Cells
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Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol. 2003 Dec; 1(3):E72.
Savage DF, Egea PF, Robles-Colmenares Y, O'Connell JD, Stroud RM. PMID: 14691544; PMCID: PMC300682.
View in:
PubMed Mentions:
112 Fields:
Translation:
Cells
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The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. Structure. 2003 Dec; 11(12):1609-20.
Foster PG, Nunes CR, Greene P, Moustakas D, Stroud RM. PMID: 14656444.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. J Synchrotron Radiat. 2004 Jan 01; 11(Pt 1):86-8.
Lee JK, Khademi S, Harries W, Savage D, Miercke L, Stroud RM. PMID: 14646142.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
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Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol. 2003 Nov 28; 334(3):435-44.
Watanabe K, Khosla C, Stroud RM, Tsai SC. PMID: 14623185.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
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Selectivity and conductance among the glycerol and water conducting aquaporin family of channels. FEBS Lett. 2003 Nov 27; 555(1):79-84.
Stroud RM, Savage D, Miercke LJ, Lee JK, Khademi S, Harries W. PMID: 14630323.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
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Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12648-53.
Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM. PMID: 14566049; PMCID: PMC240672.
View in:
PubMed Mentions:
60 Fields:
Translation:
Cells
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Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. J Biol Chem. 2003 Dec 26; 278(52):52980-7.
O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. PMID: 14555647.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug; 16(8):607-14.
Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. PMID: 12968078.
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PubMed Mentions: Fields:
Translation:
Cells
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Glycerol facilitator GlpF and the associated aquaporin family of channels. Curr Opin Struct Biol. 2003 Aug; 13(4):424-31.
Stroud RM, Miercke LJ, O'Connell J, Khademi S, Lee JK, Remis J, Harries W, Robles Y, Akhavan D. PMID: 12948772.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
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Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol. 2003 Apr; 10(4):361-8.
Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV. PMID: 12725864.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Structure of human pro-chymase: a model for the activating transition of granule-associated proteases. Biochemistry. 2003 Mar 11; 42(9):2616-24.
Reiling KK, Krucinski J, Miercke LJ, Raymond WW, Caughey GH, Stroud RM. PMID: 12614156.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
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The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng. 2003 Mar; 16(3):229-40.
Birdsall DL, Finer-Moore J, Stroud RM. PMID: 12702803.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
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Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure. 2003 Feb; 11(2):147-54.
Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. PMID: 12575934.
View in:
PubMed Mentions:
41 Fields:
Translation:
Cells
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Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie". Biochemistry. 2003 Jan 21; 42(2):239-47.
Stroud RM, Finer-Moore JS. PMID: 12525150.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry. 2003 Jan 21; 42(2):248-56.
Finer-Moore JS, Santi DV, Stroud RM. PMID: 12525151.
View in:
PubMed Mentions:
52 Fields:
Translation:
Cells
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The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme. J Eukaryot Microbiol. 2003; 50 Suppl:555-6.
O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. PMID: 14736160.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The glycerol facilitator GlpF its aquaporin family of channels, and their selectivity. Adv Protein Chem. 2003; 63:291-316.
Stroud RM, Nollert P, Miercke L. PMID: 12629974.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
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Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure. 2002 Nov; 10(11):1559-68.
Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. PMID: 12429097.
View in:
PubMed Mentions:
23 Fields:
Translation:
Cells
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Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 2002 Oct 22; 41(42):12598-606.
Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. PMID: 12379102.
View in:
PubMed Mentions:
38 Fields:
Translation:
Cells
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Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol. 2002 Jul 19; 320(4):783-99.
Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM. PMID: 12095255; PMCID: PMC3542393.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
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Structure-based studies on species-specific inhibition of thymidylate synthase. Biochim Biophys Acta. 2002 Jul 18; 1587(2-3):206-14.
Costi MP, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Soragni F, Venturelli A, Stroud RM. PMID: 12084462.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry. 2002 Jun 04; 41(22):7021-9.
Fritz TA, Liu L, Finer-Moore JS, Stroud RM. PMID: 12033935.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
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Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science. 2002 Apr 19; 296(5567):525-30.
Tajkhorshid E, Nollert P, Jensen MØ, Miercke LJ, O'Connell J, Stroud RM, Schulten K. PMID: 11964478.
View in:
PubMed Mentions:
237 Fields:
Translation:
Cells
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Encoding Selectivity of a Transmembrane Channel. ScientificWorldJournal. 2002; 2:111.
Stroud RM, Nollert P, Miercke LJW, Harries WEC, O'Connell J. PMID: 29973827; PMCID: PMC6009669.
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PubMed Mentions: Fields:
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Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry. 2002 Apr 09; 41(14):4582-94.
Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM. PMID: 11926820.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem. 2002 Mar 15; 277(11):8835-40.
Agarwalla S, Kealey JT, Santi DV, Stroud RM. PMID: 11779873.
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PubMed Mentions:
36 Fields:
Translation:
Cells
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The structure of GlpF, a glycerol conducting channel. Novartis Found Symp. 2002; 245:51-61; discussion 61-5, 165-8.
Fu D, Libson A, Stroud R. PMID: 12027015.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):14808-13.
Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM. PMID: 11752428; PMCID: PMC64940.
View in:
PubMed Mentions:
62 Fields:
Translation:
Cells
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Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. J Mol Biol. 2001 Nov 02; 313(4):813-29.
Sayre PH, Finer-Moore JS, Fritz TA, Biermann D, Gates SB, MacKellar WC, Patel VF, Stroud RM. PMID: 11697906.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol. 2001 Oct; 8(10):981-95.
Fritz TA, Tondi D, Finer-Moore JS, Costi MP, Stroud RM. PMID: 11590022.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins. FEBS Lett. 2001 Aug 31; 504(3):112-7.
Nollert P, Harries WE, Fu D, Miercke LJ, Stroud RM. PMID: 11532442.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure. 2001 May 09; 9(5):409-17.
Morse RJ, Yamamoto T, Stroud RM. PMID: 11377201.
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PubMed Mentions:
85 Fields:
Translation:
Cells
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Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking. Chem Biol. 2001 May; 8(5):445-57.
Anderson AC, O'Neil RH, Surti TS, Stroud RM. PMID: 11358692.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase. Biochem Pharmacol. 2001 Jan 15; 61(2):179-89.
Lackey DB, Groziak MP, Sergeeva M, Beryt M, Boyer C, Stroud RM, Sayre P, Park JW, Johnston P, Slamon D, Shepard HM, Pegram M. PMID: 11163332.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The signal recognition particle. Annu Rev Biochem. 2001; 70:755-75.
Keenan RJ, Freymann DM, Stroud RM, Walter P. PMID: 11395422.
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PubMed Mentions:
229 Fields:
Translation:
Cells
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Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry. 2000 Oct 24; 39(42):12796-803.
Reiling KK, Pray TR, Craik CS, Stroud RM. PMID: 11041844.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Structure of a glycerol-conducting channel and the basis for its selectivity. Science. 2000 Oct 20; 290(5491):481-6.
Fu D, Libson A, Miercke LJ, Weitzman C, Nollert P, Krucinski J, Stroud RM. PMID: 11039922.
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PubMed Mentions:
313 Fields:
Translation:
Cells
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Site-directed ligand discovery. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9367-72.
Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. PMID: 10944209; PMCID: PMC16870.
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PubMed Mentions:
135 Fields:
Translation:
Cells
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Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase. Protein Eng. 2000 Aug; 13(8):557-63.
Kawase S, Cho SW, Rozelle J, Stroud RM, Finer-Moore J, Santi DV. PMID: 10964985.
View in:
PubMed Mentions:
7 Fields:
-
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8233-8.
Chen JC, Krucinski J, Miercke LJ, Finer-Moore JS, Tang AH, Leavitt AD, Stroud RM. PMID: 10890912; PMCID: PMC26930.
View in:
PubMed Mentions:
185 Fields:
Translation:
HumansAnimalsCells
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Mesoscopic surfactant organization and membrane protein crystallization. Protein Sci. 2000 Jul; 9(7):1407-9.
Wiener MC, Verkman AS, Stroud RM, van Hoek AN. PMID: 10933509; PMCID: PMC2144676.
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PubMed Mentions: Fields:
Translation:
HumansCells
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The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design. J Mol Biol. 2000 Mar 31; 297(3):645-57.
Anderson AC, Perry KM, Freymann DM, Stroud RM. PMID: 10731418.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. Biochemistry. 2000 Mar 14; 39(10):2429-35.
Variath P, Liu Y, Lee TT, Stroud RM, Santi DV. PMID: 10704192.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
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Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". Biochemistry. 2000 Feb 08; 39(5):1011-20.
Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM. PMID: 10653645.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
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Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase. J Mol Biol. 2000 Jan 21; 295(3):377-85.
Cherbavaz DB, Lee ME, Stroud RM, Koshland DE. PMID: 10623532.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol. 2000 Jan; 7(1):23-7.
Foster PG, Huang L, Santi DV, Stroud RM. PMID: 10625422.
View in:
PubMed Mentions:
43 Fields:
Translation:
Cells
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Signal sequence recognition and protein targeting. Curr Opin Struct Biol. 1999 Dec; 9(6):754-9.
Stroud RM, Walter P. PMID: 10607673.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
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Expression, purification, and structural characterization of the bacteriorhodopsin-aspartyl transcarbamylase fusion protein. Protein Expr Purif. 1999 Nov; 17(2):324-38.
Turner GJ, Miercke LJ, Mitra AK, Stroud RM, Betlach MC, Winter-Vann A. PMID: 10545282.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. Biochemistry. 1999 Oct 19; 38(42):13829-36.
Anderson AC, O'Neil RH, DeLano WL, Stroud RM. PMID: 10529228.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat Struct Biol. 1999 Aug; 6(8):793-801.
Freymann DM, Keenan RJ, Stroud RM, Walter P. PMID: 10426959.
View in:
PubMed Mentions:
37 Fields:
Translation:
Cells
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Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem. 1999 Jun 17; 42(12):2112-24.
Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P. PMID: 10377217.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin. Protein Eng. 1999 Jun; 12(6):505-13.
Zhan H, Liu B, Reid SW, Aoki KH, Li C, Syed RS, Karkaria C, Koe G, Sitney K, Hayenga K, Mistry F, Savel L, Dreyer M, Katz BA, Schreurs J, Matthews DJ, Cheetham JC, Egrie J, Giebel LB, Stroud RM. PMID: 10388848.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 02; 38(5):1607-17.
Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. PMID: 9931028.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. J Mol Biol. 1998 Dec 04; 284(3):699-712.
Reyes CL, Sage CR, Rutenber EE, Nissen RM, Finer-Moore JS, Stroud RM. PMID: 9826509.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
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Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry. 1998 Oct 20; 37(42):14736-47.
Stout TJ, Schellenberger U, Santi DV, Stroud RM. PMID: 9778348.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 01; 395(6701):511-6.
Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. PMID: 9774108.
View in:
PubMed Mentions:
157 Fields:
Translation:
HumansAnimalsCells
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D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Biochemistry. 1998 Sep 29; 37(39):13893-901.
Sage CR, Michelitsch MD, Stout TJ, Biermann D, Nissen R, Finer-Moore J, Stroud RM. PMID: 9753479.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Ion-channel-forming colicins. Curr Opin Struct Biol. 1998 Aug; 8(4):525-33.
Stroud RM, Reiling K, Wiener M, Freymann D. PMID: 9729746.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Helical protein design. Curr Opin Biotechnol. 1998 Aug; 9(4):350-3.
Schafmeister CE, Stroud RM. PMID: 9720261.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell. 1998 Jul 24; 94(2):181-91.
Keenan RJ, Freymann DM, Walter P, Stroud RM. PMID: 9695947.
View in:
PubMed Mentions:
106 Fields:
Translation:
Cells
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The additivity of substrate fragments in enzyme-ligand binding. Structure. 1998 Jul 15; 6(7):839-48.
Stout TJ, Sage CR, Stroud RM. PMID: 9687366.
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PubMed Mentions:
24 Fields:
Translation:
Cells
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Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation. Biochemistry. 1998 Apr 14; 37(15):5107-17.
Chen JC, Miercke LJ, Krucinski J, Starr JR, Saenz G, Wang X, Spilburg CA, Lange LG, Ellsworth JL, Stroud RM. PMID: 9548741.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng. 1998 Mar; 11(3):171-83.
Birdsall DL, Huang W, Santi DV, Stroud RM, Finer-Moore J. PMID: 9613841.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry. 1998 Feb 24; 37(8):2607-21.
Rose RB, Craik CS, Stroud RM. PMID: 9485411.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J Mol Biol. 1998 Feb 13; 276(1):113-29.
Finer-Moore JS, Liu L, Birdsall DL, Brem R, Apfeld J, Santi DV, Stroud RM. PMID: 9514716.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
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Design of potent selective zinc-mediated serine protease inhibitors. Nature. 1998 Feb 05; 391(6667):608-12.
Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM. PMID: 9468142.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A novel dCMP methylase by engineering thymidylate synthase. Biochemistry. 1997 Dec 16; 36(50):15909-17.
Agarwalla S, LaPorte S, Liu L, Finer-Moore J, Stroud RM, Santi DV. PMID: 9398324.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
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A designed four helix bundle protein with native-like structure. Nat Struct Biol. 1997 Dec; 4(12):1039-46.
Schafmeister CE, LaPorte SL, Miercke LJ, Stroud RM. PMID: 9406555.
View in:
PubMed Mentions:
30 Fields:
Translation:
Cells
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Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting. Biochemistry. 1997 Nov 11; 36(45):13890-6.
Finer-Moore J, Tsutakawa SE, Cherbavaz DR, LaPorte DC, Koshland DE, Stroud RM. PMID: 9374867.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
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The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorg Med Chem. 1997 Jul; 5(7):1311-20.
Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR. PMID: 9377091.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Crystal structure of colicin Ia. Nature. 1997 Jan 30; 385(6615):461-4.
Wiener M, Freymann D, Ghosh P, Stroud RM. PMID: 9009197.
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PubMed Mentions:
76 Fields:
Translation:
Cells
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Structure of the conserved GTPase domain of the signal recognition particle. Nature. 1997 Jan 23; 385(6614):361-4.
Freymann DM, Keenan RJ, Stroud RM, Walter P. PMID: 9002524.
View in:
PubMed Mentions:
84 Fields:
Translation:
Cells
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An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry. 1996 Dec 17; 35(50):16270-81.
Sage CR, Rutenber EE, Stout TJ, Stroud RM. PMID: 8973201.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Structure. 1996 Nov 15; 4(11):1317-24.
Rutenber EE, Stroud RM. PMID: 8939755.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry. 1996 Oct 01; 35(39):12933-44.
Rose RB, Craik CS, Douglas NL, Stroud RM. PMID: 8841139.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
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A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere. Bioorg Med Chem. 1996 Sep; 4(9):1545-58.
Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC, Craik CS, Stroud RM. PMID: 8894111.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
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Balancing ATP in the cell. Nat Struct Biol. 1996 Jul; 3(7):567-9.
Stroud RM. PMID: 8673595.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry. 1996 Apr 23; 35(16):5125-36.
Finer-Moore JS, Liu L, Schafmeister CE, Birdsall DL, Mau T, Santi DV, Stroud RM. PMID: 8611496.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
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Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate. Biochemistry. 1996 Apr 02; 35(13):3944-9.
Costi PM, Liu L, Finer-Moore JS, Stroud RM, Santi DV. PMID: 8672425.
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PubMed Mentions: Fields:
Translation:
Cells
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Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase. J Mol Biol. 1996 Jan 26; 255(3):522-35.
Birdsall DL, Finer-Moore J, Stroud RM. PMID: 8568895.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
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The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure. 1996 Jan 15; 4(1):67-77.
Stout TJ, Stroud RM. PMID: 8805515.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
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Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan; 9(1):69-75.
Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. PMID: 9053905.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
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Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry. 1995 Dec 19; 34(50):16279-87.
Schiffer CA, Clifton IJ, Davisson VJ, Santi DV, Stroud RM. PMID: 8845352.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Significance of structural changes in proteins: expected errors in refined protein structures. Protein Sci. 1995 Nov; 4(11):2392-404.
Stroud RM, Fauman EB. PMID: 8563637; PMCID: PMC2143015.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
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Topochemistry for preparing ligands that dimerize receptors. Chem Biol. 1995 Sep; 2(9):591-600.
Katz BA, Stroud RM, Collins N, Liu B, Arze R. PMID: 9383463.
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PubMed Mentions: Fields:
Translation:
Cells
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Ion channel forming colicins. Curr Opin Struct Biol. 1995 Aug; 5(4):514-20.
Stroud R. PMID: 8528768.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry. 1995 Jul 04; 34(26):8264-80.
Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM. PMID: 7599119.
View in:
PubMed Mentions:
15 Fields:
Translation:
Cells
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Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex. Biochemistry. 1994 Dec 27; 33(51):15459-68.
Finer-Moore JS, Maley GF, Maley F, Montfort WR, Stroud RM. PMID: 7803410.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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The domain structure of the ion channel-forming protein colicin Ia. Nat Struct Biol. 1994 Sep; 1(9):597-604.
Ghosh P, Mel SF, Stroud RM. PMID: 7543362.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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An electrostatic highway. Nat Struct Biol. 1994 Mar; 1(3):131-4.
Stroud RM. PMID: 7656026.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. Biochemistry. 1994 Feb 15; 33(6):1502-11.
Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM. PMID: 8312270.
View in:
PubMed Mentions:
13 Fields:
Translation:
Cells
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Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor. Biochemistry. 1993 Nov 23; 32(46):12498-507.
Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM. PMID: 8241141.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science. 1993 Oct 29; 262(5134):734-8.
Schafmeister CE, Miercke LJ, Stroud RM. PMID: 8235592.
View in:
PubMed Mentions:
39 Fields:
Translation:
Cells
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Mapping a membrane-associated conformation of colicin Ia. Biochemistry. 1993 Sep 14; 32(36):9473-9.
Mel SF, Falick AM, Burlingame AL, Stroud RM. PMID: 7690252.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Two-dimensional crystallization of Escherichia coli-expressed bacteriorhodopsin and its D96N variant: high resolution structural studies in projection. Biophys J. 1993 Sep; 65(3):1295-306.
Mitra AK, Miercke LJ, Turner GJ, Shand RF, Betlach MC, Stroud RM. PMID: 8241409; PMCID: PMC1225849.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J Mol Biol. 1993 Aug 20; 232(4):1101-16.
Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM. PMID: 8371269.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
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Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry. 1993 Jul 20; 32(28):7116-25.
Perry KM, Carreras CW, Chang LC, Santi DV, Stroud RM. PMID: 8343503.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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A carboxy-terminal fragment of colicin Ia forms ion channels. J Membr Biol. 1993 Jun; 134(2):85-92.
Ghosh P, Mel SF, Stroud RM. PMID: 7692058.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase. FASEB J. 1993 May; 7(8):671-7.
Stroud RM, Finer-Moore JS. PMID: 8500692.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Structure-based discovery of inhibitors of thymidylate synthase. Science. 1993 Mar 05; 259(5100):1445-50.
Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM. PMID: 8451640.
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PubMed Mentions:
52 Fields:
Translation:
Cells
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Colicin Ia inserts into negatively charged membranes at low pH with a tertiary but little secondary structural change. Biochemistry. 1993 Mar 02; 32(8):2082-9.
Mel SF, Stroud RM. PMID: 8448167.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Bacteriorhodopsin D85N: three spectroscopic species in equilibrium. Biochemistry. 1993 Feb 09; 32(5):1332-7.
Turner GJ, Miercke LJ, Thorgeirsson TE, Kliger DS, Betlach MC, Stroud RM. PMID: 8448142.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism. Biochemistry. 1992 Dec 29; 31(51):12876-84.
Kamb A, Finer-Moore JS, Stroud RM. PMID: 1281428.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry. 1992 Oct 20; 31(41):9883-90.
Kamb A, Finer-Moore J, Calvert AH, Stroud RM. PMID: 1390771.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Reversible dissociation and unfolding of the dimeric protein thymidylate synthase. Protein Sci. 1992 Jun; 1(6):796-800.
Perry KM, Pookanjanatavip M, Zhao J, Santi DV, Stroud RM. PMID: 1304920; PMCID: PMC2142238.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Inclusion of solvation free energy with molecular mechanics energy: alanyl dipeptide as a test case. Protein Sci. 1992 Mar; 1(3):396-400.
Schiffer CA, Caldwell JW, Stroud RM, Kollman PA. PMID: 1304346; PMCID: PMC2142201.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
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Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins. 1992 Mar; 12(3):203-22.
Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM. PMID: 1557349.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin. Biochemistry. 1991 Sep 24; 30(38):9133-42.
Thorgeirsson TE, Milder SJ, Miercke LJ, Betlach MC, Shand RF, Stroud RM, Kliger DS. PMID: 1892824.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
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Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry. 1991 Sep 03; 30(35):8671-8.
Hurley JH, Dean AM, Koshland DE, Stroud RM. PMID: 1888729.
View in:
PubMed Mentions:
70 Fields:
Translation:
Cells
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Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem. 1991 Jul 25; 266(21):13828-33.
Lax I, Mitra AK, Ravera C, Hurwitz DR, Rubinstein M, Ullrich A, Stroud RM, Schlessinger J. PMID: 1856216.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Crystallization of human thymidylate synthase. J Mol Biol. 1991 May 20; 219(2):161-3.
Schiffer CA, Davisson VJ, Santi DV, Stroud RM. PMID: 2038053.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Ion channels formed by a highly charged peptide. Biochemistry. 1991 Apr 09; 30(14):3551-7.
Ghosh P, Stroud RM. PMID: 1707312.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Wild-type and mutant bacterioopsins D85N, D96N, and R82Q: high-level expression in Escherichia coli. Biochemistry. 1991 Mar 26; 30(12):3082-8.
Shand RF, Miercke LJ, Mitra AK, Fong SK, Stroud RM, Betlach MC. PMID: 2007142.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
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Wild-type and mutant bacteriorhodopsins D85N, D96N, and R82Q: purification to homogeneity, pH dependence of pumping, and electron diffraction. Biochemistry. 1991 Mar 26; 30(12):3088-98.
Miercke LJ, Betlach MC, Mitra AK, Shand RF, Fong SK, Stroud RM. PMID: 1848786.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Resonance Raman spectra of bacteriorhodopsin mutants with substitutions at Asp-85, Asp-96, and Arg-82. Photochem Photobiol. 1991 Mar; 53(3):341-6.
Lin SW, Fodor SP, Miercke LJ, Shand RF, Betlach MC, Stroud RM, Mathies RA. PMID: 2062880.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin. Biochemistry. 1991 Feb 19; 30(7):1751-61.
Milder SJ, Thorgeirsson TE, Miercke LJ, Stroud RM, Kliger DS. PMID: 1993191.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
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1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures. Proteins. 1991; 10(3):171-87.
Earnest T, Fauman E, Craik CS, Stroud R. PMID: 1881877.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels. Biochemistry. 1990 Dec 18; 29(50):11009-23.
Stroud RM, McCarthy MP, Shuster M. PMID: 1703009.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Saturation site-directed mutagenesis of thymidylate synthase. J Biol Chem. 1990 Nov 05; 265(31):18776-9.
Climie S, Ruiz-Perez L, Gonzalez-Pacanowska D, Prapunwattana P, Cho SW, Stroud R, Santi DV. PMID: 2229040.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
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Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin. Biochemistry. 1990 Sep 11; 29(36):8351-7.
Mangel WF, Singer PT, Cyr DM, Umland TC, Toledo DL, Stroud RM, Pflugrath JW, Sweet RM. PMID: 2252895.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Regulation of an enzyme by phosphorylation at the active site. Science. 1990 Aug 31; 249(4972):1012-6.
Hurley JH, Dean AM, Sohl JL, Koshland DE, Stroud RM. PMID: 2204109.
View in:
PubMed Mentions:
70 Fields:
Translation:
Cells
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Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. Biochemistry. 1990 Jul 31; 29(30):6977-86.
Finer-Moore JS, Montfort WR, Stroud RM. PMID: 2223755.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry. 1990 Jul 31; 29(30):6964-77.
Montfort WR, Perry KM, Fauman EB, Finer-Moore JS, Maley GF, Hardy L, Maley F, Stroud RM. PMID: 2223754.
View in:
PubMed Mentions:
47 Fields:
Translation:
Cells
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Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J Biol Chem. 1990 Mar 05; 265(7):3599-602.
Hurley JH, Dean AM, Thorsness PE, Koshland DE, Stroud RM. PMID: 2406256.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
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High sensitivity electron diffraction analysis. A study of divalent cation binding to purple membrane. Biophys J. 1990 Feb; 57(2):301-11.
Mitra AK, Stroud RM. PMID: 2317552; PMCID: PMC1280671.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
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Prediction of homologous protein structures based on conformational searches and energetics. Proteins. 1990; 8(1):30-43.
Schiffer CA, Caldwell JW, Kollman PA, Stroud RM. PMID: 2217162.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins. 1990; 8(4):315-33.
Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM. PMID: 2128651.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Preparative purification of functional bacteriorhodopsin by high-performance size-exclusion chromatography. J Chromatogr. 1989 Dec 08; 483:331-40.
Miercke LJ, Stroud RM, Dratz EA. PMID: 2560474.
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PubMed Mentions: Fields:
-
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8635-9.
Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE, Stroud RM. PMID: 2682654; PMCID: PMC298342.
View in:
PubMed Mentions:
62 Fields:
Translation:
Cells
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Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6645-9.
Poulter L, Earnest JP, Stroud RM, Burlingame AL. PMID: 2771948; PMCID: PMC297901.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol. 1989 Aug; 109(2):755-74.
Mitra AK, McCarthy MP, Stroud RM. PMID: 2760111; PMCID: PMC2115713.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Changes in conformation upon agonist binding, and nonequivalent labeling, of the membrane-spanning regions of the nicotinic acetylcholine receptor subunits. J Biol Chem. 1989 Jun 25; 264(18):10911-6.
McCarthy MP, Stroud RM. PMID: 2732250.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Purification of bacteriorhodopsin and characterization of mature and partially processed forms. J Biol Chem. 1989 May 05; 264(13):7531-5.
Miercke LJ, Ross PE, Stroud RM, Dratz EA. PMID: 2708376.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Conformational states of the nicotinic acetylcholine receptor from Torpedo californica induced by the binding of agonists, antagonists, and local anesthetics. Equilibrium measurements using tritium-hydrogen exchange. Biochemistry. 1989 Jan 10; 28(1):40-8.
McCarthy MP, Stroud RM. PMID: 2706266.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Cesium ion liquid secondary ion mass spectrometry of membrane-bound glycoproteins: structural and topological considerations of acetylcholine receptor from Torpedo californica. Biomed Environ Mass Spectrom. 1988 Oct; 16(1-12):25-30.
Poulter L, Earnest JP, Stroud RM, Burlingame AL. PMID: 3242677.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol. 1988 Sep; 8(9):3797-808.
Basson ME, Thorsness M, Finer-Moore J, Stroud RM, Rine J. PMID: 3065625; PMCID: PMC365438.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments. Biochemistry. 1988 Apr 19; 27(8):2763-71.
Basus VJ, Billeter M, Love RA, Stroud RM, Kuntz ID. PMID: 3401447.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science. 1987 Aug 21; 237(4817):905-9.
Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. PMID: 3112942.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import. EMBO J. 1987 Mar; 6(3):705-11.
Vassarotti A, Stroud R, Douglas M. PMID: 2884105; PMCID: PMC553454.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Atomic structure of thymidylate synthase: target for rational drug design. Science. 1987 Jan 23; 235(4787):448-55.
Hardy LW, Finer-Moore JS, Montfort WR, Jones MO, Santi DV, Stroud RM. PMID: 3099389.
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PubMed Mentions:
78 Fields:
Translation:
Cells
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An archetypal molecular transducer of the nervous system: the acetylcholine receptor. Res Publ Assoc Res Nerv Ment Dis. 1987; 65:51-63.
Stroud RM. PMID: 2455312.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Topological mapping and the ionic channel in an acetylcholine receptor. Soc Gen Physiol Ser. 1987; 41:67-75.
Stroud RM. PMID: 2436314.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng. 1986 Oct-Nov; 1(1):47-54.
Masters SB, Stroud RM, Bourne HR. PMID: 3148932.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng. 1986 Oct-Nov; 1(1):37-46.
Love RA, Stroud RM. PMID: 3507686.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Cation binding sites on the projected structure of bacteriorhodopsin. Biophys J. 1986 Aug; 50(2):277-84.
Katre NV, Kimura Y, Stroud RM. PMID: 3741984; PMCID: PMC1329744.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Location of terbium binding sites on acetylcholine receptor-enriched membranes. J Mol Biol. 1986 Jun 20; 189(4):673-80.
Fairclough RH, Miake-Lye RC, Stroud RM, Hodgson KO, Doniach S. PMID: 3783687.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Purification and crystallization of creatine kinase from rabbit skeletal muscle. J Biol Chem. 1986 Mar 15; 261(8):3732-6.
Hershenson S, Helmers N, Desmueles P, Stroud R. PMID: 3949787.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The molecular neurobiology of the acetylcholine receptor. Annu Rev Neurosci. 1986; 9:383-413.
McCarthy MP, Earnest JP, Young EF, Choe S, Stroud RM. PMID: 2423008.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem. 1985 Jan 10; 260(1):522-30.
Liscum L, Finer-Moore J, Stroud RM, Luskey KL, Brown MS, Goldstein JL. PMID: 3965461.
View in:
PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
-
Acetylcholine receptor structure, function, and evolution. Annu Rev Cell Biol. 1985; 1:317-51.
Stroud RM, Finer-Moore J. PMID: 2435309.
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27 Fields:
Translation:
AnimalsCells
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Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):626-30.
Young EF, Ralston E, Blake J, Ramachandran J, Hall ZW, Stroud RM. PMID: 3881770; PMCID: PMC397094.
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20 Fields:
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AnimalsCells
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Location of an extrinsic label in the primary and tertiary structure of bacteriorhodopsin. Biophys J. 1984 Aug; 46(2):195-203.
Katre NV, Finer-Moore J, Stroud RM, Hayward SB. PMID: 6478034; PMCID: PMC1435042.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Subunit secondary structure in filamentous viruses: predictions and observations. J Biomol Struct Dyn. 1984 Aug; 2(1):93-100.
Finer-Moore J, Stroud RM, Prescott B, Thomas GJ. PMID: 6400935.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci U S A. 1984 Jan; 81(1):155-9.
Finer-Moore J, Stroud RM. PMID: 6320162; PMCID: PMC344629.
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PubMed Mentions:
132 Fields:
Translation:
AnimalsCells
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Subunit organization and structure of an acetylcholine receptor. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:9-20.
Fairclough RH, Finer-Moore J, Love RA, Kristofferson D, Desmeules PJ, Stroud RM. PMID: 6586365.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Linking regions between helices in bacteriorhodopsin revealed. Biophys J. 1982 Mar; 37(3):589-602.
Agard DA, Stroud RM. PMID: 7074187; PMCID: PMC1328844.
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24 Fields:
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Structure and function of an acetylcholine receptor. Biophys J. 1982 Jan; 37(1):371-83.
Kistler J, Stroud RM, Klymkowsky MW, Lalancette RA, Fairclough RH. PMID: 7055628; PMCID: PMC1329155.
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PubMed Mentions:
60 Fields:
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AnimalsCells
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Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids. Biophys J. 1981 Dec; 36(3):743-57.
Stroud RM, Serwer P, Ross MJ. PMID: 7326332; PMCID: PMC1327657.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. J Mol Biol. 1981 Sep 25; 151(3):491-517.
Hayward SB, Stroud RM. PMID: 7338903.
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PubMed Mentions:
32 Fields:
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Cells
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Attachment site(s) of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4068-72.
Katre NV, Wolber PK, Stoeckenius W, Stroud RM. PMID: 6794028; PMCID: PMC319727.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Crystalline arrays of membrane-bound acetylcholine receptor. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3678-82.
Kistler J, Stroud RM. PMID: 6943572; PMCID: PMC319634.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem. 1981 Mar 01; 111(2):257-68.
Agard DA, Steinberg RA, Stroud RM. PMID: 7247021.
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7 Fields:
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Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma. Mol Immunol. 1980 Nov; 17(11):1365-72.
Nagasawa S, Stroud RM. PMID: 7464836.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol. 1980 Jun; 85(3):823-38.
Klymkowsky MW, Heuser JE, Stroud RM. PMID: 6993498; PMCID: PMC2111471.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol. 1979 Mar 05; 128(3):319-34.
Klymkowsky MW, Stroud RM. PMID: 439138.
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PubMed Mentions:
37 Fields:
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AnimalsCells
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Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J. 1979 Mar; 25(3):495-512.
Stroud RM, Agard DA. PMID: 318062; PMCID: PMC1328487.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol. 1977 Nov; 116(4):635-59.
Ross MJ, Klymkowsky MW, Agard DA, Stroud RM. PMID: 563472.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry. 1977 Feb 22; 16(4):654-64.
Kossiakoff AA, Chambers JL, Kay LM, Stroud RM. PMID: 556951.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Mechanisms of zymogen activation. Annu Rev Biophys Bioeng. 1977; 6:177-93.
Stroud RM, Kossiakoff AA, Chambers JL. PMID: 17350.
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38 Fields:
Translation:
Cells
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Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy. Biochemistry. 1976 Aug 10; 15(16):3450-8.
Koeppe RE, Stroud RM. PMID: 986162.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Biochemistry. 1976 Aug 10; 15(16):3458-64.
Krieger M, Koeppe RE, Stroud RM. PMID: 8090.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A pulsed diffusion technique for the growth of protein crystals for x-ray diffraction. J Mol Biol. 1975 Oct 15; 98(1):155-60.
Koeppe RE, Stroud RM. PMID: 1195375.
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Cells
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The structural basis for binding of complement by immunoglobulin M. J Exp Med. 1974 Oct 01; 140(4):1117-21.
Hurst MM, Volanakis JE, Hester RB, Stroud RM, Bennett JC. PMID: 4427090; PMCID: PMC2139640.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Silver ion inhibition of serine proteases: crystallographic study of silver-trypsin. Biochem Biophys Res Commun. 1974 Jul 10; 59(1):70-4.
Chambers JL, Christoph GG, Krieger M, Kay L, Stroud RM. PMID: 4842294.
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PubMed Mentions:
1 Fields:
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Cells
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Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol. 1974 Feb 25; 83(2):209-30.
Krieger M, Kay LM, Stroud RM. PMID: 4821871.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol. 1974 Feb 25; 83(2):185-208.
Stroud RM, Kay LM, Dickerson RE. PMID: 4821870.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol. 1972; 36:125-40.
Stroud RM, Kay LM, Dickerson RE. PMID: 4508129.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells