Oscar Campos, PhD

Title(s)Postdoctoral Scholar, Cellular Molecular Pharmacology
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0002-5645-7275 Additional info
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    Western University, London, CanadaB.Sc.06/2008Kinesiology
    Western University, London, CanadaM.Sc.06/2011Kinesiology
    University of California, Los Angeles, Los Angeles, CaliforniaPh.D.06/2018Molecular Biology

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    My PhD work in Siavash Kurdistani's Lab at UCLA was focused on uncovering the evolutionary origins of the eukaryotic epigenetic control machinery. This machinery, the core component of which is the histones, is unique to eukaryotes and critical for multicellular life. My teammates and I made the surprising and groundbreaking discovery that the histone H3 is an oxidoreductase enzyme. This function is critical for eukaryotic cells and raises the unprecedented and profound notion that histones may have first evolved to enable the eukaryotic ancestors to adapt to oxygenated life before being incorporated as a way to compact DNA or regulate gene expression.

    As a postdoc in Wendell Lim's lab at UCSF, I am expanding on my interests in epigenetics by developing a synthetic biology framework for engineering epigenetic and cell differentiation control systems in mammalian cells, with particular emphasis on CAR T cells. My goal is to develop a toolbox of synthetic cell circuits incorporating epigenetic regulation that will enable programmable differentiation of T cells into multiple subtypes with complementary therapeutic phenotypes.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The histone H3-H4 tetramer is a copper reductase enzyme. Science. 2020 07 03; 369(6499):59-64. Attar N, Campos OA, Vogelauer M, Cheng C, Xue Y, Schmollinger S, Salwinski L, Mallipeddi NV, Boone BA, Yen L, Yang S, Zikovich S, Dardine J, Carey MF, Merchant SS, Kurdistani SK. PMID: 32631887.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. J Biol Chem. 2017 08 11; 292(32):13197-13204. Xue Y, Schmollinger S, Attar N, Campos OA, Vogelauer M, Carey MF, Merchant SS, Kurdistani SK. PMID: 28637866.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    3. Evolution of histone 2A for chromatin compaction in eukaryotes. Elife. 2014 Jun 17; 3. Macadangdang BR, Oberai A, Spektor T, Campos OA, Sheng F, Carey MF, Vogelauer M, Kurdistani SK. PMID: 24939988.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    4. The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents. Metabolism. 2013 Oct; 62(10):1485-94. Hall KE, McDonald MW, Grisé KN, Campos OA, Noble EG, Melling CW. PMID: 23810201.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    5. High-intensity endurance training results in faster vessel-specific rate of vasorelaxation in type 1 diabetic rats. PLoS One. 2013; 8(3):e59678. Murias JM, Dey A, Campos OA, Estaki M, Hall KE, Melling CW, Noble EG. PMID: 23527249.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    6. Vessel-specific rate of vasorelaxation is slower in diabetic rats. Diab Vasc Dis Res. 2013 Mar; 10(2):179-86. Murias JM, Campos OA, Hall KE, McDonald MW, Melling CW, Noble EG. PMID: 22947492.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
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