Geeta Narlikar, PhD

InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    ATP-dependent and independent mechanisms of regulating chromatin states
    NIH/NIGMS R35GM127020May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Mechanistic dissection of HP1 mediated heterochromatin
    NIH/NIGMS R01GM108455May 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Mechanistic Analysis of Chromatin Remodeling
    NIH/NIGMS R01GM073767Apr 1, 2005 - Nov 30, 2018
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Larson AG, Narlikar G. The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation. Biochemistry. 2018 May 01; 57(17):2540-2548. PMID: 29644850.
      View in: PubMed
    2. Gamarra N, Johnson SL, Trnka MJ, Burlingame AL, Narlikar G. The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h. Elife. 2018 Apr 17; 7. PMID: 29664398.
      View in: PubMed
    3. Zhou CY, Johnson SL, Lee LJ, Longhurst AD, Beckwith SL, Johnson MJ, Morrison AJ, Narlikar G. The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Mol Cell. 2018 Feb 15; 69(4):677-688.e9. PMID: 29452642.
      View in: PubMed
    4. Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar G. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol. 2017 Nov 24; 429(23):3666-3677. PMID: 28942089.
      View in: PubMed
    5. Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar G. Liquid droplet formation by HP1a suggests a role for phase separation in heterochromatin. Nature. 2017 07 13; 547(7662):236-240. PMID: 28636604.
      View in: PubMed
    6. Zhou CY, Stoddard CI, Johnston JB, Trnka MJ, Echeverria I, Palovcak E, Sali A, Burlingame AL, Cheng Y, Narlikar G. Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones. Cell Rep. 2017 06 06; 19(10):2033-2044. PMID: 28591576.
      View in: PubMed
    7. Sinha KK, Gross JD, Narlikar G. Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler. Science. 2017 01 20; 355(6322). PMID: 28104838.
      View in: PubMed
    8. Zhou CY, Johnson SL, Gamarra NI, Narlikar G. Mechanisms of ATP-Dependent Chromatin Remodeling Motors. Annu Rev Biophys. 2016 Jul 05; 45:153-81. PMID: 27391925.
      View in: PubMed
    9. Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar G, Almeida R. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 2016 04 28; 5. PMID: 27130520; PMCID: PMC4880442.
    10. Zhou CY, Narlikar G. Analysis of Nucleosome Sliding by ATP-Dependent Chromatin Remodeling Enzymes. Methods Enzymol. 2016; 573:119-35. PMID: 27372751.
      View in: PubMed
    11. Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar G, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P. A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS One. 2015; 10(5):e0126420. PMID: 25997164; PMCID: PMC4440767.
    12. Leonard JD, Narlikar G. A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler. Mol Cell. 2015 Mar 05; 57(5):850-859. PMID: 25684208.
      View in: PubMed
    13. Racki LR, Naber N, Pate E, Leonard JD, Cooke R, Narlikar G. The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme. J Mol Biol. 2014 May 15; 426(10):2034-44. PMID: 24607692; PMCID: PMC4059342.
    14. Canzio D, Larson A, Narlikar G. Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol. 2014 Jun; 24(6):377-86. PMID: 24618358; PMCID: PMC4077871.
    15. Narlikar G, Sundaramoorthy R, Owen-Hughes T. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes. Cell. 2013 Aug 01; 154(3):490-503. PMID: 23911317.
      View in: PubMed
    16. Al-Sady B, Madhani HD, Narlikar G. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91. PMID: 23849629; PMCID: PMC3752401.
    17. Shiau C, Trnka MJ, Bozicevic A, Ortiz Torres I, Al-Sady B, Burlingame AL, Narlikar G, Fujimori DG. Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase. Chem Biol. 2013 Apr 18; 20(4):494-9. PMID: 23601638; PMCID: PMC3704229.
    18. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar G. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. PMID: 23485968; PMCID: PMC3907283.
    19. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar G, Madhani HD. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63. PMID: 22733737; PMCID: PMC3396509.
    20. Shahian T, Narlikar G. Analysis of changes in nucleosome conformation using fluorescence resonance energy transfer. Methods Mol Biol. 2012; 833:337-49. PMID: 22183603.
      View in: PubMed
    21. Armache KJ, Garlick JD, Canzio D, Narlikar G, Kingston RE. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011 Nov 18; 334(6058):977-82. PMID: 22096199; PMCID: PMC4098850.
    22. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar G. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5. PMID: 21673141; PMCID: PMC3127919.
    23. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar G, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. PMID: 21211724; PMCID: PMC3752404.
    24. Rowe CE, Narlikar G. The ATP-dependent remodeler RSC transfers histone dimers and octamers through the rapid formation of an unstable encounter intermediate. Biochemistry. 2010 Nov 16; 49(45):9882-90. PMID: 20853842; PMCID: PMC2976819.
    25. Narlikar G. A proposal for kinetic proof reading by ISWI family chromatin remodeling motors. Curr Opin Chem Biol. 2010 Oct; 14(5):660-5. PMID: 20833099; PMCID: PMC2953606.
    26. Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar G. The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24; 462(7276):1016-21. PMID: 20033039; PMCID: PMC2869534.
    27. Blosser TR, Yang JG, Stone MD, Narlikar G, Zhuang X. Dynamics of nucleosome remodelling by individual ACF complexes. Nature. 2009 Dec 24; 462(7276):1022-7. PMID: 20033040; PMCID: PMC2835771.
    28. Partensky PD, Narlikar G. Chromatin remodelers act globally, sequence positions nucleosomes locally. J Mol Biol. 2009 Aug 07; 391(1):12-25. PMID: 19450608; PMCID: PMC2813840.
    29. Chang EY, Ferreira H, Somers J, Nusinow DA, Owen-Hughes T, Narlikar G. MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF. Biochemistry. 2008 Dec 23; 47(51):13726-32. PMID: 19035833.
      View in: PubMed
    30. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar G, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 03; 322(5898):43-4. PMID: 18832628; PMCID: PMC4479142.
    31. Racki LR, Narlikar G. ATP-dependent chromatin remodeling enzymes: two heads are not better, just different. Curr Opin Genet Dev. 2008 Apr; 18(2):137-44. PMID: 18339542; PMCID: PMC2494867.
    32. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar G, Shokat KM. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 2007 Mar 09; 128(5):1003-12. PMID: 17350582; PMCID: PMC2932701.
    33. Yang JG, Narlikar G. FRET-based methods to study ATP-dependent changes in chromatin structure. Methods. 2007 Mar; 41(3):291-5. PMID: 17309839; PMCID: PMC1941662.
    34. Yang JG, Madrid TS, Sevastopoulos E, Narlikar G. The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing. Nat Struct Mol Biol. 2006 Dec; 13(12):1078-83. PMID: 17099699.
      View in: PubMed
    35. He X, Fan HY, Narlikar G, Kingston RE. Human ACF1 alters the remodeling strategy of SNF2h. J Biol Chem. 2006 Sep 29; 281(39):28636-47. PMID: 16877760.
      View in: PubMed
    36. Mahajan MC, Narlikar G, Boyapaty G, Kingston RE, Weissman SM. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15012-7. PMID: 16217013; PMCID: PMC1257739.
    37. Fan HY, Narlikar G, Kingston RE. Noncovalent modification of chromatin: different remodeled products with different ATPase domains. Cold Spring Harb Symp Quant Biol. 2004; 69:183-92. PMID: 16117648.
      View in: PubMed
    38. Fan HY, He X, Kingston RE, Narlikar G. Distinct strategies to make nucleosomal DNA accessible. Mol Cell. 2003 May; 11(5):1311-22. PMID: 12769854.
      View in: PubMed
    39. Aoyagi S, Narlikar G, Zheng C, Sif S, Kingston RE, Hayes JJ. Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions. Mol Cell Biol. 2002 Jun; 22(11):3653-62. PMID: 11997502; PMCID: PMC133810.
    40. Narlikar G, Fan HY, Kingston RE. Cooperation between complexes that regulate chromatin structure and transcription. Cell. 2002 Feb 22; 108(4):475-87. PMID: 11909519.
      View in: PubMed
    41. Narlikar G, Phelan ML, Kingston RE. Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity. Mol Cell. 2001 Dec; 8(6):1219-30. PMID: 11779498.
      View in: PubMed
    42. Aalfs JD, Narlikar G, Kingston RE. Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H. J Biol Chem. 2001 Sep 07; 276(36):34270-8. PMID: 11435432.
      View in: PubMed
    43. Jónsson ZO, Dhar SK, Narlikar G, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem. 2001 May 11; 276(19):16279-88. PMID: 11278922.
      View in: PubMed
    44. Guyon JR, Narlikar G, Sullivan EK, Kingston RE. Stability of a human SWI-SNF remodeled nucleosomal array. Mol Cell Biol. 2001 Feb; 21(4):1132-44. PMID: 11158300; PMCID: PMC99567.
    45. Kingston RE, Narlikar G. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev. 1999 Sep 15; 13(18):2339-52. PMID: 10500090.
      View in: PubMed
    46. Guyon JR, Narlikar G, Sif S, Kingston RE. Stable remodeling of tailless nucleosomes by the human SWI-SNF complex. Mol Cell Biol. 1999 Mar; 19(3):2088-97. PMID: 10022896; PMCID: PMC84002.
    47. Phelan ML, Sif S, Narlikar G, Kingston RE. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol Cell. 1999 Feb; 3(2):247-53. PMID: 10078207.
      View in: PubMed