Peter Walter, PhD

Title(s)Howard Hughes Investigator, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-476-4636
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    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    Breakthrough Foundation2018Breakthrough Prize in Life Science
    Vilcek Foundation2015Vilcek Prize in Biomedical Science
    Lasker Foundation2014Lasker Basic Medical Research Award
    UCSF2014Shaw Prize in Life Science and Medicine
    UCSF2012Paul Ehrlich and Ludwig Darmstaedter Prize

    Collapse Overview 
    Collapse Overview
    Our laboratory seeks a molecular understanding of how cells control the quality of their proteins and organelles during homeostasis and stress. We are identifying the machinery and mechanisms that ensure proper protein synthesis, folding, and targeting, as well as the pathways that allow organelles to communicate and regulate their abundance. Additionally, we aim to understand how the rewiring of these processes leads to, or prevents the progression of disease. Our laboratory uses a diverse array of techniques, ranging from biochemical reconstitution to genetics, to fuel our search for fundamental discoveries in cell biology.
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural Basis of Protein Homeostasis
    NIH U01GM098254Sep 30, 2012 - Jul 31, 2016
    Role: Principal Investigator
    The integrated stress response in cognitive disorders
    NIH R01NS076708Mar 15, 2012 - Mar 31, 2026
    Role: Co-Principal Investigator
    Stress Proteins in Growth, Development &Disease 2007Gordon Research Conference
    NIH R13AG030760Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH P50GM073210Sep 24, 2004 - Aug 31, 2015
    Role: Co-Investigator
    QUATTRO ALLIANCE FOR SCIENCE AND LANGUAGE INTEGRATION
    NIH R25RR018504Sep 30, 2003 - Aug 31, 2007
    Role: Co-Principal Investigator
    Molecular Cell Biology Gordon Conference
    NIH R13CA091820Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    PROTEIN TRANSLOCATION IN YEAST
    NIH R01GM037485Dec 1, 1986 - Nov 30, 1999
    Role: Principal Investigator
    Co-translational ER quality control
    NIH R01GM032384Jul 1, 1983 - Apr 30, 2024
    Role: Principal Investigator
    MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANES
    NIH R37GM032384Jul 1, 1983 - Jun 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. eIF2B Conformation and Assembly State Regulate the Integrated Stress Response. The FASEB Journal. 2021 May 14; 35(S1). Michael Schoof, Morgane Boone, Lan Wang, Rosalie Lawrence, Adam Frost, Peter Walter. .
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    2. Regulating ER protein homeostasis by differentially processing mRNAs. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Jirka Peschek, Peter Walter. .
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    3. Abstract # 2056 Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Brain Behavior and Immunity. 2019 Feb 1; 76:e5. K. Krukowski, A. Chou, T. Jopson, P. Jun Zhu, M. Costa-Mattioli, P. Walter, S. Rosi. .
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    4. Leonardo Gallery: Scientific Delirium Madness 4.0. Leonardo. 2018 Jun 1; 51(03):227-238. Margot H. Knight, Marco Buongiorno Nardelli, Anna M. Davidson, Ken Eklund, Katharine Hawthorne, GinaRae LaCerva, Adria C. LeBoeuf, Patrice Le Gal, Ainissa Ramirez, Heather Spence, Javiera Tejerina-Risso, Peter Walter. .
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    5. Regulating ER Protein Folding Homeostasis By Distinctively Processing mRNAs. The FASEB Journal. 2018 Apr 1; 32:653.9-653.9. Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Peter Walter. .
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    6. CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate. Blood. 2016 Dec 2; 128(22):384-384. Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu. .
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    7. Identification of key components involved in mtDNA inheritance during cell division (965.1). The FASEB Journal. 2014 Apr 1; 28. Beatriz Camacho, Christof Osman, Peter Walter. .
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    8. A quaternary equation for interdisciplinary medical research (IMR). Journal of Translational Medicine. 2012 Oct 1; 10(Suppl 2):a49. Marc Shuman, Jim Wells, K Shokat, S Bernales, P Walter, Leonard Shultz, Neal Goodwin. .
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    9. Multi-Modality Imaging of Multiple Myeloma Bone Disease In Orthotopic Xenograft Models. Blood. 2010 Nov 19; 116(21):5014-5014. Diego Acosta-Alvear, Byron C Hann, Brian A Rabinovich, Marc A Shuman, Peter Walter. .
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    10. Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90. Blood. 2008 Nov 16; 112(11):5160-5160. Marc J Braunstein, Craig M Scott, Shannon Behrman, Peter Walter, Peter Wipf, Eric LP Smith, Sadeaqua S Scott, H. Uwe Klueppelberg, Jeffrey L Brodsky, Olcay Batuman. .
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    11. Helenius et al. reply. Nature. 2008 Jul 1; 454(7204):e4-e5. Jonne Helenius, Davis T. W. Ng, Cristina L. Marolda, Peter Walter, Miguel A. Valvano, Markus Aebi. .
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    12. In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone. Blood. 2007 Nov 16; 110(11):1524-1524. M.J. Braunstein, C.M. Scott, S. Berman, P. Walter, P. Wipf, J.L. Brodsky, O. Batuman. .
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    13. Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma. Blood. 2006 Nov 16; 108(11):5070-5070. Marc J. Braunstein, Na Liu, Uwe Klueppelberg, Craig Scott, Shannon Behrman, Can Tamucin, Peter Walter, Peter Wipf, Jeffrey Brodsky, Olcay Batuman. .
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    14. Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor. Biochemistry. 2005 May 1; 44(20):7602-7602. Shu-ou Shan, Peter Walter. .
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    15. 8 The Unfolded Protein Response. Protein Targeting, Transport, and Translocation. 2002 Jan 1; (Proc Natl Acad Sci USA921995):151-179. Carmela Sidrauski, Jason H. Brickner, Peter Walter. .
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    16. Ier1 p: A Kinase and Site-Specific Endoribonuclease. Nuclease Methods and Protocols. 2001 Jan 1; 160:25-36. Tania N. Gonzalez, Peter Walter. .
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    17. Progress torwards the crystal structure of Ffh, the bacterial homolog of SRP54. Acta Crystallographica Section A: Foundations and advances. 1996 Aug 8; 52(a1):c167-c167. D. Freymann, R. Keenan, R. Stroud, P. Walter. .
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    18. The SRP-Dependent Protein Targeting Pathway in Saccharomyces Cerevisiae. Protein Synthesis and Targeting in Yeast. 1993 Jan 1; 283-292. Peter Walter, Stephen C. Ogg, Byron C. Hann. .
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    19. Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum. Membrane Biogenesis and Protein Targeting. 1992 Jan 1; 22:129-136. Stephen C. Ogg, Jodi M. Nunnari, Joshua D. Miller, Peter Walter. .
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    20. C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae. Molecular and Cellular Biology. 1992 Jan 1; 12(1):276-282. N Green, P Walter. .
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    21. Characterization of the rough endoplasmic reticulum ribosome-binding activity. Trends in Cell Biology. 1991 Nov 1; 1(5):115. J.M. Nunnari, D.L. Zimmerman, S.C. Ogg, P. Walter. .
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    22. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Molecular and Cellular Biology. 1991 Aug 1; 11(8):3949-3959. K Strub, J Moss, P Walter. .
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    23. Small ribonucleoproteins. Current Opinion in Structural Biology. 1991 Apr 1; 1(2):251-257. Sandra L. Wolin, Peter Walter. .
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    24. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Molecular and Cellular Biology. 1990 Feb 1; 10(2):777-784. K Strub, P Walter. .
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    25. Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation. Molecular and Cellular Biology. 1989 Aug 1; 9(8):3400-3410. J K Ngsee, W Hansen, P Walter, M Smith. .
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    26. Substrate requirements for SRP-mediated targeting to the ER membrane. Molecular Biology Reports. 1987 Sep 1; 12(3):219-219. V. Siegel, P. D. Garcia, P. Walter. .
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    27. Functional dissection of the signal recognition particle. Molecular Biology Reports. 1987 Sep 1; 12(3):220-220. V. Siegel, M. Poritz, P. Walter. .
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    28. Structure and Function of the Signal Recognition Particle. Genetic Engineering. 1986 Jan 1; 181-196. Vivian Siegel, Peter Walter. .
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    29. The Protein Translocation Machinery of the Endoplasmic Reticulum: The Signal Hypothesis Ten Years Later. Protein Compartmentalization. 1986 Jan 1; 1-13. Peter Walter, Vivian Siegel, Leander Lauffer, Pablo D. Garcia. .
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    30. Intracellular Protein Topogenesis. New Insights into Cell and Membrane Transport Processes. 1986 Jan 1; 277-283. Günter Blobel, Peter Walter, Reid Gilmore. .
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    31. THE PROTEIN TRANSLOCATION MACHINERY OF THE ENDOPLASMIC RETICULUM. Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression. 1982 Jan 1; 291-293. PETER WALTER, REID GILMORE, MATTHIAS MULLER, GUNTER BLOBEL. .
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