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Peter Walter, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Phone415-476-5017
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    Breakthrough Foundation2018Breakthrough Prize in Life Science
    Vilcek Foundation2015Vilcek Prize in Biomedical Science
    Lasker Foundation2014Lasker Basic Medical Research Award
    UCSF2014Shaw Prize in Life Science and Medicine
    UCSF2012Paul Ehrlich and Ludwig Darmstaedter Prize

    Collapse Overview 
    Collapse Overview
    Our laboratory seeks a molecular understanding of how cells control the quality of their proteins and organelles during homeostasis and stress. We are identifying the machinery and mechanisms that ensure proper protein synthesis, folding, and targeting, as well as the pathways that allow organelles to communicate and regulate their abundance. Additionally, we aim to understand how the rewiring of these processes leads to, or prevents the progression of disease. Our laboratory uses a diverse array of techniques, ranging from biochemical reconstitution to genetics, to fuel our search for fundamental discoveries in cell biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Structural Basis of Protein Homeostasis
    NIH/NIGMS U01GM098254Sep 30, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Stress Proteins in Growth, Development &Disease 2007Gordon Research Conference
    NIH/NIA R13AG030760Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH/NIGMS P50GM073210Sep 24, 2004 - Aug 31, 2014
    Role: Co-Investigator
    QUATTRO ALLIANCE FOR SCIENCE AND LANGUAGE INTEGRATION
    NIH/NCRR R25RR018504Sep 30, 2003 - Aug 31, 2007
    Role: Co-Principal Investigator
    Molecular Cell Biology Gordon Conference
    NIH/NCI R13CA091820Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    PROTEIN TRANSLOCATION IN YEAST
    NIH/NIGMS R01GM037485Dec 1, 1986 - Nov 30, 1999
    Role: Principal Investigator
    Co-translational ER quality control
    NIH/NIGMS R01GM032384Jul 1, 1983 - Apr 30, 2020
    Role: Principal Investigator
    MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANES
    NIH/NIGMS R37GM032384Jul 1, 1983 - Jun 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhu PJ, Khatiwada S, Cui Y, Reineke LC, Dooling SW, Kim JJ, Li W, Walter P, Costa-Mattioli M. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019 11 15; 366(6467):843-849. PMID: 31727829.
      View in: PubMed
    2. Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. Elife. 2019 10 15; 8. PMID: 31612858.
      View in: PubMed
    3. Anand AA, Walter P. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. FEBS J. 2019 Sep 24. PMID: 31550413.
      View in: PubMed
    4. Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P. Mrx6 regulates mitochondrial DNA copy number in S. cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol Biol Cell. 2019 Sep 18; mbcE19080470. PMID: 31532710.
      View in: PubMed
    5. Walter P, Mullins D. From symbiont to parasite: the evolution of for-profit science publishing. Mol Biol Cell. 2019 Sep 15; 30(20):2537-2542. PMID: 31539315.
      View in: PubMed
    6. Karagöz GE, Acosta-Alvear D, Walter P. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2019 Sep 03; 11(9). PMID: 30670466.
      View in: PubMed
    7. Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M. Withdrawal: Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem. 2019 Aug 09; 294(32):12263. PMID: 31399538.
      View in: PubMed
    8. Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1a through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. 2019 Aug 13; 116(33):16420-16429. PMID: 31371506.
      View in: PubMed
    9. Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. Elife. 2019 06 25; 8. PMID: 31237564.
      View in: PubMed
    10. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. PMID: 31149896.
      View in: PubMed
    11. Bielecki J, Hantke MF, Daurer BJ, Reddy HKN, Hasse D, Larsson DSD, Gunn LH, Svenda M, Munke A, Sellberg JA, Flueckiger L, Pietrini A, Nettelblad C, Lundholm I, Carlsson G, Okamoto K, Timneanu N, Westphal D, Kulyk O, Higashiura A, van der Schot G, Loh ND, Wysong TE, Bostedt C, Gorkhover T, Iwan B, Seibert MM, Osipov T, Walter P, Hart P, Bucher M, Ulmer A, Ray D, Carini G, Ferguson KR, Andersson I, Andreasson J, Hajdu J, Maia FRNC. Electrospray sample injection for single-particle imaging with x-ray lasers. Sci Adv. 2019 May; 5(5):eaav8801. PMID: 31058226.
      View in: PubMed
    12. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019 05 03; 364(6439):491-495. PMID: 31048491.
      View in: PubMed
    13. Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM. Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2097-2102. PMID: 30674674.
      View in: PubMed
    14. Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 2018 12 24; 7. PMID: 30582518.
      View in: PubMed
    15. Lam M, Lawrence DA, Ashkenazi A, Walter P. Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. Cell Death Differ. 2018 08; 25(8):1530-1531. PMID: 29991746.
      View in: PubMed
    16. Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 2018 07 09; 7. PMID: 29985129.
      View in: PubMed
    17. Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439). PMID: 29720449.
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    18. Walter P, Anderson D. Günter Blobel (1936-2018). Science. 2018 Apr 27; 360(6387):383. PMID: 29700255.
      View in: PubMed
    19. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. Retraction Notice to: The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host Microbe. 2018 04 11; 23(4):571. PMID: 29649448.
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    20. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). PMID: 29599213.
      View in: PubMed
    21. Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 2017 10 03; 6. PMID: 28971800.
      View in: PubMed
    22. Guydosh NR, Kimmig P, Walter P, Green R. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. Elife. 2017 09 25; 6. PMID: 28945192.
      View in: PubMed
    23. Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. J Cell Sci. 2017 Oct 01; 130(19):3222-3233. PMID: 28794014.
      View in: PubMed
    24. Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6420-E6426. PMID: 28696288.
      View in: PubMed
    25. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2017 06 01; 36(11):1640. PMID: 28572284.
      View in: PubMed
    26. Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1395-E1404. PMID: 28137856.
      View in: PubMed
    27. Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjevic K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M. eIF2a-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. Elife. 2016 12 13; 5. PMID: 27960077.
      View in: PubMed
    28. Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. Elife. 2016 12 07; 5. PMID: 27925580.
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    29. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. PMID: 27841764.
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    30. Walter P, Yamamoto KR. Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions. Cell. 2016 Sep 22; 167(1):16-19. PMID: 27634318.
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    31. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9015-20. PMID: 27450084.
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    32. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 2016 07 20; 5. PMID: 27435961.
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    33. Gallagher CM, Walter P. Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. Elife. 2016 07 20; 5. PMID: 27435962.
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    34. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016 07 20; 5. PMID: 27435960.
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    35. Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjevic K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2a phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine. Elife. 2016 Mar 01; 5. PMID: 26928234.
      View in: PubMed
    36. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016 Mar 01; 5. PMID: 26928076.
      View in: PubMed
    37. Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5' untranslated region shapes the integrated stress response. Science. 2016 Jan 29; 351(6272):aad3867. PMID: 26823435.
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    38. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. PMID: 26789650.
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    39. Elvekrog MM, Walter P. Dynamics of co-translational protein targeting. Curr Opin Chem Biol. 2015 Dec; 29:79-86. PMID: 26517565.
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    40. Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 2015 Dec; 16(12):1688-98. PMID: 26483401.
      View in: PubMed
    41. Lang AB, John Peter AT, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol. 2015 Sep 14; 210(6):883-90. PMID: 26370498.
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    42. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. PMID: 26327694.
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    43. Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19; 4. PMID: 25986605.
      View in: PubMed
    44. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. PMID: 25875391.
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    45. Sidrauski C, McGeachy AM, Ingolia NT, Walter P. The small molecule ISRIB reverses the effects of eIF2a phosphorylation on translation and stress granule assembly. Elife. 2015 Feb 26; 4. PMID: 25719440.
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    46. Osman C, Noriega TR, Okreglak V, Fung JC, Walter P. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E947-56. PMID: 25730886.
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    47. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440.
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    48. van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Gómez Puerta S, Korennykh AV, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife. 2014 Dec 30; 3:e05031. PMID: 25549299.
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    49. Noriega TR, Chen J, Walter P, Puglisi JD. Real-time observation of signal recognition particle binding to actively translating ribosomes. Elife. 2014 Oct 30; 3. PMID: 25358118.
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    50. Walter P. Lasker Award winner Peter Walter. Nat Med. 2014 Oct; 20(10):1112-4. PMID: 25295946.
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    51. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14800-5. PMID: 25275008.
      View in: PubMed
    52. Schuck S, Gallagher CM, Walter P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci. 2014 Sep 15; 127(Pt 18):4078-88. PMID: 25052096.
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    53. Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014 Jul 04; 345(6192):98-101. PMID: 24994655.
      View in: PubMed
    54. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82. PMID: 24974795.
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    55. Okreglak V, Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8019-24. PMID: 24821790.
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    56. Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem. 2014 Jul 11; 289(28):19294-305. PMID: 24808175.
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    57. Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ. Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans. PLoS Genet. 2014 Apr; 10(4):e1004292. PMID: 24762475.
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    58. Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. Heat shock transcription factor s32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol. 2013 Dec; 11(12):e1001735. PMID: 24358019.
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    59. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. PMID: 23741617.
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    60. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-569. PMID: 23684307.
      View in: PubMed
    61. Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife. 2013 May 14; 2:e00422. PMID: 23682313.
      View in: PubMed
    62. Walter P. Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson. BMC Biol. 2013 Apr 15; 11:34. PMID: 23587131.
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    63. Walter P, Metzger J, Thiel C, Helms V. Predicting where small molecules bind at protein-protein interfaces. PLoS One. 2013; 8(3):e58583. PMID: 23505538.
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    64. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a013169. PMID: 23388626.
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    65. Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife. 2012 Oct 15; 1:e00048. PMID: 23066505.
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    66. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3084-93. PMID: 23054834.
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    67. Pincus D, Walter P. A first line of defense against ER stress. J Cell Biol. 2012 Aug 06; 198(3):277-9. PMID: 22869593.
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    68. Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol. 2012 Aug 06; 198(3):405-20. PMID: 22869600.
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    69. Korennykh A, Walter P. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 2012; 28:251-77. PMID: 23057742.
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    70. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011 Nov 25; 334(6059):1081-6. PMID: 22116877.
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    71. Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol. 2011; 2011:232037. PMID: 21977030.
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    72. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2011 Sep 16; 30(21):4465-78. PMID: 21926971.
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    73. Gardner BM, Walter P. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science. 2011 Sep 30; 333(6051):1891-4. PMID: 21852455.
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    74. Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14151-6. PMID: 21825164.
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    75. Nguyen TX, Chandrasekar S, Neher S, Walter P, Shan SO. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Biochemistry. 2011 Aug 23; 50(33):7208-17. PMID: 21780778.
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    76. Johnen S, Kazanskaya O, Armogan N, Stickelmann C, Stöcker M, Walter P, Thumann G. Endogenic regulation of proliferation and zinc transporters by pigment epithelial cells nonvirally transfected with PEDF. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5400-7. PMID: 21508100.
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    77. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 06; 9:48. PMID: 21729334.
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    78. Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 06; 9:47. PMID: 21729333.
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    79. Walter P. Peter Walter: investigating how the ER handles secretory proteins. Interview by Sedwick Caitlin. J Cell Biol. 2011 Apr 04; 193(1):4-5. PMID: 21464225.
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    80. Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol. 2011 Apr 04; 193(1):171-84. PMID: 21444684.
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    81. Behrman S, Acosta-Alvear D, Walter P. A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol. 2011 Mar 21; 192(6):919-27. PMID: 21402790.
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    82. Hayat S, Walter P, Park Y, Helms V. Prediction of the exposure status of transmembrane beta barrel residues from protein sequence. J Bioinform Comput Biol. 2011 Feb; 9(1):43-65. PMID: 21328706.
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    215. Despons L, Senger B, Fasiolo F, Walter P. Binding of the yeast tRNA(Met) anticodon by the cognate methionyl-tRNA synthetase involves at least two independent peptide regions. J Mol Biol. 1992 Jun 05; 225(3):897-907. PMID: 1602489.
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    218. Hann BC, Stirling CJ, Walter P. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity. Nature. 1992 Apr 09; 356(6369):532-3. PMID: 1313947.
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    219. Green N, Fang H, Walter P. Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae. J Cell Biol. 1992 Feb; 116(3):597-604. PMID: 1730771.
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    220. Green N, Walter P. C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae. Mol Cell Biol. 1992 Jan; 12(1):276-82. PMID: 1729604.
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    226. Strub K, Moss J, Walter P. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol. 1991 Aug; 11(8):3949-59. PMID: 1712900.
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    227. Brennwald PJ, Siegel V, Walter P, Wise JA. Sequence and structure of Tetrahymena SRP RNA. Nucleic Acids Res. 1991 Apr 25; 19(8):1942. PMID: 1709498.
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    228. Thrift RN, Andrews DW, Walter P, Johnson AE. A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation. J Cell Biol. 1991 Mar; 112(5):809-21. PMID: 1999459.
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    229. Zopf D, Bernstein HD, Johnson AE, Walter P. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. EMBO J. 1990 Dec; 9(13):4511-7. PMID: 1702385.
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    230. Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science. 1990 Nov 23; 250(4984):1111-7. PMID: 1701272.
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    232. Zimmerman DL, Walter P. Reconstitution of protein translocation activity from partially solubilized microsomal vesicles. J Biol Chem. 1990 Mar 05; 265(7):4048-53. PMID: 2105958.
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    233. Strub K, Walter P. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Mol Cell Biol. 1990 Feb; 10(2):777-84. PMID: 2153922.
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    234. Strub K, Walter P. Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9747-51. PMID: 2557625.
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    235. Hann BC, Poritz MA, Walter P. Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. J Cell Biol. 1989 Dec; 109(6 Pt 2):3223-30. PMID: 2557350.
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    236. Wolin SL, Walter P. Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate. J Cell Biol. 1989 Dec; 109(6 Pt 1):2617-22. PMID: 2556403.
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    237. Krieg UC, Johnson AE, Walter P. Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel. J Cell Biol. 1989 Nov; 109(5):2033-43. PMID: 2808520.
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    238. Bernstein HD, Rapoport TA, Walter P. Cytosolic protein translocation factors. Is SRP still unique? Cell. 1989 Sep 22; 58(6):1017-9. PMID: 2550141.
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    240. Ngsee JK, Hansen W, Walter P, Smith M. Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation. Mol Cell Biol. 1989 Aug; 9(8):3400-10. PMID: 2677671.
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    241. Siegel V, Walter P. Assembly of proteins in the endoplasmic reticulum. Curr Opin Cell Biol. 1989 Aug; 1(4):635-8. PMID: 2697275.
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    243. Green GN, Hansen W, Walter P. The use of gene-fusions to determine membrane protein topology in Saccharomyces cerevisiae. J Cell Sci Suppl. 1989; 11:109-13. PMID: 2693456.
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    244. Wolin SL, Walter P. Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J. 1988 Nov; 7(11):3559-69. PMID: 2850168.
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    245. Lingelbach K, Zwieb C, Webb JR, Marshallsay C, Hoben PJ, Walter P, Dobberstein B. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res. 1988 Oct 25; 16(20):9431-42. PMID: 2460823.
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    246. Poritz MA, Strub K, Walter P. Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Cell. 1988 Oct 07; 55(1):4-6. PMID: 2458843.
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    247. Siegel V, Walter P. Functional dissection of the signal recognition particle. Trends Biochem Sci. 1988 Aug; 13(8):314-6. PMID: 2856455.
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    248. Siegel V, Walter P. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J. 1988 Jun; 7(6):1769-75. PMID: 3169004.
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    250. Kassenbrock CK, Garcia PD, Walter P, Kelly RB. Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro. Nature. 1988 May 05; 333(6168):90-3. PMID: 3129663.
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    251. Hansen W, Walter P. Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae. J Cell Biol. 1988 Apr; 106(4):1075-81. PMID: 3283144.
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    252. Garcia PD, Walter P. Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated. J Cell Biol. 1988 Apr; 106(4):1043-8. PMID: 2834400.
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    253. Garcia PD, Ou JH, Rutter WJ, Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol. 1988 Apr; 106(4):1093-104. PMID: 3283145.
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    255. Siegel V, Walter P. Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell. 1988 Jan 15; 52(1):39-49. PMID: 2830980.
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    256. Andrews DW, Walter P, Ottensmeyer FP. Evidence for an extended 7SL RNA structure in the signal recognition particle. EMBO J. 1987 Nov; 6(11):3471-7. PMID: 2828031.
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    258. Garcia PD, Ghrayeb J, Inouye M, Walter P. Wild type and mutant signal peptides of Escherichia coli outer membrane lipoprotein interact with equal efficiency with mammalian signal recognition particle. J Biol Chem. 1987 Jul 15; 262(20):9463-8. PMID: 3298258.
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    260. Krieg UC, Walter P, Johnson AE. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8604-8. PMID: 3095839.
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    262. Hansen W, Garcia PD, Walter P. In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor. Cell. 1986 May 09; 45(3):397-406. PMID: 3009026.
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    263. Siegel V, Walter P. Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact. Nature. 1986 Mar 6-12; 320(6057):81-4. PMID: 2419765.
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    264. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature. 1986 Mar 13-19; 320(6058):134-9. PMID: 3754034.
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    267. Siegel V, Walter P. Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane. J Cell Biol. 1985 Jun; 100(6):1913-21. PMID: 2581979.
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    268. Andrews DW, Walter P, Ottensmeyer FP. Structure of the signal recognition particle by electron microscopy. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):785-9. PMID: 3856232.
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    272. Walter P, Blobel G. Disassembly and reconstitution of signal recognition particle. Cell. 1983 Sep; 34(2):525-33. PMID: 6413076.
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    273. Erickson AH, Walter P, Blobel G. Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. Biochem Biophys Res Commun. 1983 Aug 30; 115(1):275-80. PMID: 6137219.
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    274. Walter P, Blobel G. Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties. Methods Enzymol. 1983; 96:682-91. PMID: 6197610.
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    276. Gilmore R, Walter P, Blobel G. Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol. 1982 Nov; 95(2 Pt 1):470-7. PMID: 6292236.
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    278. Müller M, Ibrahimi I, Chang CN, Walter P, Blobel G. A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum. J Biol Chem. 1982 Oct 25; 257(20):11860-3. PMID: 6749848.
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    279. Walter P, Blobel G. Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature. 1982 Oct 21; 299(5885):691-8. PMID: 6181418.
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    280. Anderson DJ, Walter P, Blobel G. Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane. J Cell Biol. 1982 May; 93(2):501-6. PMID: 7047541.
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    286. Jackson RC, Walter P, Blobel G. Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane. Nature. 1980 Jul 10; 286(5769):174-6. PMID: 6995850.
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