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Peter Walter, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-476-4636
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    Breakthrough Foundation2018Breakthrough Prize in Life Science
    Vilcek Foundation2015Vilcek Prize in Biomedical Science
    Lasker Foundation2014Lasker Basic Medical Research Award
    UCSF2014Shaw Prize in Life Science and Medicine
    UCSF2012Paul Ehrlich and Ludwig Darmstaedter Prize

    Collapse Overview 
    Collapse Overview
    Our laboratory seeks a molecular understanding of how cells control the quality of their proteins and organelles during homeostasis and stress. We are identifying the machinery and mechanisms that ensure proper protein synthesis, folding, and targeting, as well as the pathways that allow organelles to communicate and regulate their abundance. Additionally, we aim to understand how the rewiring of these processes leads to, or prevents the progression of disease. Our laboratory uses a diverse array of techniques, ranging from biochemical reconstitution to genetics, to fuel our search for fundamental discoveries in cell biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Structural Basis of Protein Homeostasis
    NIH/NIGMS U01GM098254Sep 30, 2012 - Jul 31, 2015
    Role: Principal Investigator
    Stress Proteins in Growth, Development &Disease 2007Gordon Research Conference
    NIH/NIA R13AG030760Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH/NIGMS P50GM073210Sep 24, 2004 - Jul 31, 2009
    Role: Co-Investigator
    QUATTRO ALLIANCE FOR SCIENCE AND LANGUAGE INTEGRATION
    NIH/NCRR R25RR018504Sep 30, 2003 - Aug 31, 2007
    Role: Co-Principal Investigator
    Molecular Cell Biology Gordon Conference
    NIH/NCI R13CA091820Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    PROTEIN TRANSLOCATION IN YEAST
    NIH/NIGMS R01GM037485Dec 1, 1986 - Nov 30, 1999
    Role: Principal Investigator
    Co-translational ER quality control
    NIH/NIGMS R01GM032384Jul 1, 1983 - Jun 30, 2007
    Role: Principal Investigator
    MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANES
    NIH/NIGMS R37GM032384Jul 1, 1983 - Jun 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. Nat Microbiol. 2020 Jul 20. Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM. PMID: 32690955.
      View in: PubMed   Mentions:    Fields:    
    2. Genotoxic stress triggers the activation of IRE1a-dependent RNA decay to modulate the DNA damage response. Nat Commun. 2020 05 14; 11(1):2401. Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C. PMID: 32409639.
      View in: PubMed   Mentions:    Fields:    
    3. The integrated stress response: From mechanism to disease. Science. 2020 04 24; 368(6489). Costa-Mattioli M, Walter P. PMID: 32327570.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. IRE1a Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment. Cancer Res. 2020 Jun 01; 80(11):2368-2379. Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, Solon M, Modrusan Z, Rudolph J, Koeppen H, Walter P, Ashkenazi A. PMID: 32265225.
      View in: PubMed   Mentions:    Fields:    
    5. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Sci Adv. 2020 04; 6(14):eaay9572. Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z. PMID: 32270040.
      View in: PubMed   Mentions:    Fields:    
    6. Regulating ER protein homeostasis by differentially processing mRNAs. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Jirka Peschek, Peter Walter. .
      View in: Publisher Site   Mentions:
    7. Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma. J Neurotrauma. 2020 Jun 01; 37(11):1370-1380. Krukowski K, Nolan A, Frias ES, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S. PMID: 31884883.
      View in: PubMed   Mentions:    Fields:    
    8. Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife. 2020 Jan 30; 9. Wang L, Myasnikov A, Pan X, Walter P. PMID: 31999255.
      View in: PubMed   Mentions:    Fields:    
    9. Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress. Elife. 2020 Jan 06; 9. Lam M, Marsters SA, Ashkenazi A, Walter P. PMID: 31904339.
      View in: PubMed   Mentions: 3     Fields:    
    10. Quantitative microscopy reveals dynamics and fate of clustered IRE1a. Proc Natl Acad Sci U S A. 2020 01 21; 117(3):1533-1542. Belyy V, Tran NH, Walter P. PMID: 31871156.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019 11 15; 366(6467):843-849. Zhu PJ, Khatiwada S, Cui Y, Reineke LC, Dooling SW, Kim JJ, Li W, Walter P, Costa-Mattioli M. PMID: 31727829.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. FEBS J. 2020 Jan; 287(2):239-245. Anand AA, Walter P. PMID: 31550413.
      View in: PubMed   Mentions: 1     Fields:    
    13. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. Elife. 2019 10 15; 8. Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. PMID: 31612858.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol Biol Cell. 2020 Mar 19; 31(7):527-545. Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P. PMID: 31532710.
      View in: PubMed   Mentions:    Fields:    
    15. From symbiont to parasite: the evolution of for-profit science publishing. Mol Biol Cell. 2019 09 15; 30(20):2537-2542. Walter P, Mullins D. PMID: 31539315.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2019 09 03; 11(9). Karagöz GE, Acosta-Alvear D, Walter P. PMID: 30670466.
      View in: PubMed   Mentions: 10     Fields:    
    17. A Novel Role of Fungal Type I Myosin in Regulating Membrane Properties and Its Association with d-Amino Acid Utilization in Cryptococcus gattii. mBio. 2019 08 27; 10(4). Khanal Lamichhane A, Garraffo HM, Cai H, Walter PJ, Kwon-Chung KJ, Chang YC. PMID: 31455652.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Withdrawal: Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem. 2019 Aug 09; 294(32):12263. Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M. PMID: 31399538.
      View in: PubMed   Mentions:    Fields:    
    19. Disruption of IRE1a through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16420-16429. Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. PMID: 31371506.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. Elife. 2019 06 25; 8. Peschek J, Walter P. PMID: 31237564.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells. mBio. 2019 06 18; 10(3). Davis MJ, Moyer S, Hoke ES, Sionov E, Mayer-Barber KD, Barber DL, Cai H, Jenkins L, Walter PJ, Chang YC, Kwon-Chung KJ. PMID: 31213551.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Electrospray sample injection for single-particle imaging with x-ray lasers. Sci Adv. 2019 05; 5(5):eaav8801. Bielecki J, Hantke MF, Daurer BJ, Reddy HKN, Hasse D, Larsson DSD, Gunn LH, Svenda M, Munke A, Sellberg JA, Flueckiger L, Pietrini A, Nettelblad C, Lundholm I, Carlsson G, Okamoto K, Timneanu N, Westphal D, Kulyk O, Higashiura A, van der Schot G, Loh ND, Wysong TE, Bostedt C, Gorkhover T, Iwan B, Seibert MM, Osipov T, Walter P, Hart P, Bucher M, Ulmer A, Ray D, Carini G, Ferguson KR, Andersson I, Andreasson J, Hajdu J, Maia FRNC. PMID: 31058226.
      View in: PubMed   Mentions:    Fields:    
    24. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019 05 03; 364(6439):491-495. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. PMID: 31048491.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Abstract # 2056 Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Brain Behavior and Immunity. 2019 Feb 1; 76:e5. K. Krukowski, A. Chou, T. Jopson, P. Jun Zhu, M. Costa-Mattioli, P. Walter, S. Rosi. .
      View in: Publisher Site   Mentions:
    26. Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2097-2102. Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM. PMID: 30674674.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay. Bio-protocol. 2019 Jan 1; 9(14). G. Karagöz, Jirka Peschek, Peter Walter, Diego Acosta-Alvear. .
      View in: Publisher Site   Mentions:
    28. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 2018 12 24; 7. Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. PMID: 30582518.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    29. Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. Cell Death Differ. 2018 08; 25(8):1530-1531. Lam M, Lawrence DA, Ashkenazi A, Walter P. PMID: 29991746.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 2018 07 09; 7. Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. PMID: 29985129.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439). Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. PMID: 29720449.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Günter Blobel (1936-2018). Science. 2018 Apr 27; 360(6387):383. Walter P, Anderson D. PMID: 29700255.
      View in: PubMed   Mentions:    Fields:    
    33. Retraction Notice to: The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host Microbe. 2018 04 11; 23(4):571. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. PMID: 29649448.
      View in: PubMed   Mentions: 1     Fields:    
    34. Regulating ER Protein Folding Homeostasis By Distinctively Processing mRNAs. The FASEB Journal. 2018 Apr 1; 32:653.9-653.9. Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Peter Walter. .
      View in: Publisher Site   Mentions:
    35. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. PMID: 29599213.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    36. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 2017 10 03; 6. Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. PMID: 28971800.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    37. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. Elife. 2017 09 25; 6. Guydosh NR, Kimmig P, Walter P, Green R. PMID: 28945192.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. J Cell Sci. 2017 Oct 01; 130(19):3222-3233. Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M. PMID: 28794014.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6420-E6426. Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. PMID: 28696288.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2017 06 01; 36(11):1640. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. PMID: 28572284.
      View in: PubMed   Mentions:    Fields:    
    41. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1395-E1404. Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E. PMID: 28137856.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    42. eIF2a-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. Elife. 2016 12 13; 5. Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjevic K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M. PMID: 27960077.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. Elife. 2016 12 07; 5. Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. PMID: 27925580.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate. Blood. 2016 Dec 2; 128(22):384-384. Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu. .
      View in: Publisher Site   Mentions:
    45. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. PMID: 27841764.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions. Cell. 2016 Sep 22; 167(1):16-19. Walter P, Yamamoto KR. PMID: 27634318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9015-20. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. PMID: 27450084.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    48. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 2016 07 20; 5. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW. PMID: 27435961.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    49. Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. Elife. 2016 07 20; 5. Gallagher CM, Walter P. PMID: 27435962.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    50. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016 07 20; 5. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. PMID: 27435960.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    51. Evaluation of Retinal Function and Morphology of the Pink-Eyed Royal College of Surgeons (RCS) Rat: A Comparative Study of in Vivo and in Vitro Methods. Curr Eye Res. 2017 02; 42(2):273-281. Rösch S, Aretzweiler C, Müller F, Walter P. PMID: 27362633.
      View in: PubMed   Mentions:
    52. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016 Mar 01; 5. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. PMID: 26928076.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    53. Translational control by eIF2a phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine. Elife. 2016 Mar 01; 5. Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjevic K, Walter P, Dani JA, Costa-Mattioli M. PMID: 26928234.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    54. Translation from the 5' untranslated region shapes the integrated stress response. Science. 2016 Jan 29; 351(6272):aad3867. Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. PMID: 26823435.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    55. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. PMID: 26789650.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    56. Dynamics of co-translational protein targeting. Curr Opin Chem Biol. 2015 Dec; 29:79-86. Elvekrog MM, Walter P. PMID: 26517565.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    57. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 2015 Dec; 16(12):1688-98. Peschek J, Acosta-Alvear D, Mendez AS, Walter P. PMID: 26483401.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    58. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol. 2015 Sep 14; 210(6):883-90. Lang AB, John Peter AT, Walter P, Kornmann B. PMID: 26370498.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    59. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. PMID: 26327694.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    60. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015 May 19; 4. Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. PMID: 25986605.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    61. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    62. The small molecule ISRIB reverses the effects of eIF2a phosphorylation on translation and stress granule assembly. Elife. 2015 Feb 26; 4. Sidrauski C, McGeachy AM, Ingolia NT, Walter P. PMID: 25719440.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    63. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E947-56. Osman C, Noriega TR, Okreglak V, Fung JC, Walter P. PMID: 25730886.
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    64. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. PMID: 25564440.
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    66. Real-time observation of signal recognition particle binding to actively translating ribosomes. Elife. 2014 Oct 30; 3. Noriega TR, Chen J, Walter P, Puglisi JD. PMID: 25358118.
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    67. Lasker Award winner Peter Walter. Nat Med. 2014 Oct; 20(10):1112-4. Walter P. PMID: 25295946.
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    68. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14800-5. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. PMID: 25275008.
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    69. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci. 2014 Sep 15; 127(Pt 18):4078-88. Schuck S, Gallagher CM, Walter P. PMID: 25052096.
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    70. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014 Jul 04; 345(6192):98-101. Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. PMID: 24994655.
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    71. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. PMID: 24974795.
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    72. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8019-24. Okreglak V, Walter P. PMID: 24821790.
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    73. Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem. 2014 Jul 11; 289(28):19294-305. Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. PMID: 24808175.
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    74. Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans. PLoS Genet. 2014 Apr; 10(4):e1004292. Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ. PMID: 24762475.
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    75. Identification of key components involved in mtDNA inheritance during cell division (965.1). The FASEB Journal. 2014 Apr 1; 28. Beatriz Camacho, Christof Osman, Peter Walter. .
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    76. Heat shock transcription factor s32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol. 2013 Dec; 11(12):e1001735. Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. PMID: 24358019.
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    77. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. PMID: 23741617.
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    78. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-569. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. PMID: 23684307.
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    79. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife. 2013 May 14; 2:e00422. Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. PMID: 23682313.
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    80. Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson. BMC Biol. 2013 Apr 15; 11:34. Walter P. PMID: 23587131.
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    82. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a013169. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. PMID: 23388626.
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    83. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife. 2012 Oct 15; 1:e00048. Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. PMID: 23066505.
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    84. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3084-93. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. PMID: 23054834.
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    85. A quaternary equation for interdisciplinary medical research (IMR). Journal of Translational Medicine. 2012 Oct 1; 10(Suppl 2):a49. Marc Shuman, Jim Wells, K Shokat, S Bernales, P Walter, Leonard Shultz, Neal Goodwin. .
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    88. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 2012; 28:251-77. Korennykh A, Walter P. PMID: 23057742.
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    92. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science. 2011 Sep 30; 333(6051):1891-4. Gardner BM, Walter P. PMID: 21852455.
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    93. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14151-6. Kornmann B, Osman C, Walter P. PMID: 21825164.
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    95. Endogenic regulation of proliferation and zinc transporters by pigment epithelial cells nonvirally transfected with PEDF. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5400-7. Johnen S, Kazanskaya O, Armogan N, Stickelmann C, Stöcker M, Walter P, Thumann G. PMID: 21508100.
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    98. Presence of xenogenic mouse RNA in RPE and IPE cells cultured on mitotically inhibited 3T3 fibroblasts. Invest Ophthalmol Vis Sci. 2011 Apr 25; 52(5):2817-24. Johnen S, Wickert L, Meier M, Salz AK, Walter P, Thumann G. PMID: 21220557.
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    103. Multi-Modality Imaging of Multiple Myeloma Bone Disease In Orthotopic Xenograft Models. Blood. 2010 Nov 19; 116(21):5014-5014. Diego Acosta-Alvear, Byron C Hann, Brian A Rabinovich, Marc A Shuman, Peter Walter. .
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    165. Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature. 2002 Jan 24; 415(6870):447-50. Helenius J, Ng DT, Marolda CL, Walter P, Valvano MA, Aebi M. PMID: 11807558.
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    255. Evolution of aminoacyl-tRNA synthetase quaternary structure and activity: Saccharomyces cerevisiae mitochondrial phenylalanyl-tRNA synthetase. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8387-91. Sanni A, Walter P, Boulanger Y, Ebel JP, Fasiolo F. PMID: 1924298.
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    258. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol. 1991 Aug; 11(8):3949-59. Strub K, Moss J, Walter P. PMID: 1712900.
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    261. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. EMBO J. 1990 Dec; 9(13):4511-7. Zopf D, Bernstein HD, Johnson AE, Walter P. PMID: 1702385.
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    262. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science. 1990 Nov 23; 250(4984):1111-7. Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P. PMID: 1701272.
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    283. Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae. J Cell Biol. 1988 Apr; 106(4):1075-81. Hansen W, Walter P. PMID: 3283144.
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    284. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol. 1988 Apr; 106(4):1093-104. Garcia PD, Ou JH, Rutter WJ, Walter P. PMID: 3283145.
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    294. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8604-8. Krieg UC, Walter P, Johnson AE. PMID: 3095839.
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    297. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature. 1986 Mar 13-19; 320(6058):134-9. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P. PMID: 3754034.
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