Param Priya Singh, PhD

Title(s)Assistant Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1349B
San Francisco CA 94143
ORCID ORCID Icon0000-0002-3325-8767 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CAPostdoc12/2022Aging, Diapause
    Sorbonne University, Paris, FrancePh.D.01/2014Disease Genomics
    Persistent Systems, Pune, IndiaSoftware engineer10/2009Clinical databases
    Collapse Awards and Honors
    Center for Computational, Evolutionary and Human Genomics (CEHG), Stanford2014Postdoctoral Fellowship
    The National League Against Cancer, France2013Graduate research award
    Erasmus Mundus, European Union2010Ph.D. Fellowship
    Council for Scientific and Industrial Research, India2008Junior Research Fellowship
    University of Pune2006Ramachandran M.S. Fellowship

    Collapse Overview 
    Collapse Overview
    Our lab is interested in decoding the genomic basis of extreme survival strategies and longevity using African killifish as the model system. Due to their harsh natural habitat, African killifish have evolved a developmental state analogous to 'suspended animation' called diapause and the shortest vertebrate lifespan in captivity. Together, diapause and the compressed lifespan make killifish an ideal model to identify new mechanisms for long-term protection and to study vertebrate aging at a rapid and high-throughput scale. We aim to utilize unbiased, comparative, and multidisciplinary approaches by integrating computational genomics and CRISPR-based perturbations to decode the complexity of gene regulation during diapause and aging in vertebrates and to leverage this knowledge to improve human health.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Considerations for reproducible omics in aging research. Nat Aging. 2023 08; 3(8):921-930. Singh PP, Benayoun BA. PMID: 37386258; PMCID: PMC10527412.
      View in: PubMed   Mentions: Translation:Cells
    2. Identification of protein aggregates in the aging vertebrate brain with prion-like and phase separation properties . bioRxiv [Preprint]. 2022. Harel I, Chen YR, Ziv I, Singh PP, Negredo PN, Goshtchevsky U, Wang W, Astre G, Moses E, McKay A, Machado BE, Hebestreit K, Yin S, Alvarado AS, Jarosz DF, Brunet A. View Publication.
    3. Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate . bioRxiv [Preprint]. 2022. Chen YR, Harel I, Singh PP , Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A, Jarosz DF. View Publication.
    4. Evolution of diapause in the African turquoise killifish by remodeling ancient gene regulatory landscape . bioRxiv [Preprint]. 2021. Singh PP, Reeves GA, Contrepois K, Ellenberger M, Hu CK, Snyder MP, Brunet A. View Publication.
    5. Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells. Channels (Austin). 2020 12; 14(1):101-109. Arbabian A, Iftinca M, Altier C, Singh PP, Isambert H, Coscoy S. PMID: 32186440; PMCID: PMC7153789.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Vertebrate diapause preserves organisms long term through Polycomb complex members. Science. 2020 02 21; 367(6480):870-874. Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A. PMID: 32079766; PMCID: PMC7532943.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    7. OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates. Nucleic Acids Res. 2020 01 08; 48(D1):D724-D730. Singh PP, Isambert H. PMID: 31612943; PMCID: PMC7145513.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    8. The Genetics of Aging: A Vertebrate Perspective. Cell. 2019 03 21; 177(1):200-220. Singh PP, Demmitt BA, Nath RD, Brunet A. PMID: 30901541; PMCID: PMC7592626.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimals
    9. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses. Genome Res. 2019 04; 29(4):697-709. Benayoun BA, Pollina EA, Singh PP, Mahmoudi S, Harel I, Casey KM, Dulken BW, Kundaje A, Brunet A. PMID: 30858345; PMCID: PMC6442391.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    10. The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development. BMC Genomics. 2018 02 20; 19(1):155. Wagner JT, Singh PP, Romney AL, Riggs CL, Minx P, Woll SC, Roush J, Warren WC, Brunet A, Podrabsky JE. PMID: 29463212; PMCID: PMC5819677.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Learning causal networks with latent variables from multivariate information in genomic data. PLoS Comput Biol. 2017 Oct; 13(10):e1005662. Verny L, Sella N, Affeldt S, Singh PP, Isambert H. PMID: 28968390; PMCID: PMC5685645.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Progranulin, lysosomal regulation and neurodegenerative disease. Nat Rev Neurosci. 2017 06; 18(6):325-333. Kao AW, McKay A, Singh PP, Brunet A, Huang EJ. PMID: 28435163; PMCID: PMC6040832.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    13. The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan. Cell. 2015 Dec 03; 163(6):1539-54. Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A. PMID: 26638078; PMCID: PMC4684691.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    14. Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes. PLoS Comput Biol. 2015 Jul; 11(7):e1004394. Singh PP, Arora J, Isambert H. PMID: 26181593; PMCID: PMC4504502.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    15. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. 2015 Feb 26; 160(5):1013-1026. Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A. PMID: 25684364; PMCID: PMC4344913.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    16. Human dominant disease genes are enriched in paralogs originating from whole genome duplication. PLoS Comput Biol. 2014 Jul; 10(7):e1003754. Singh PP, Affeldt S, Malaguti G, Isambert H. PMID: 25080083; PMCID: PMC4117431.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    17. On the retention of gene duplicates prone to dominant deleterious mutations. Theor Popul Biol. 2014 May; 93:38-51. Malaguti G, Singh PP, Isambert H. PMID: 24530892.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. [Evolution and cancer: expansion of dangerous gene repertoire by whole genome duplications]. Med Sci (Paris). 2013 Apr; 29(4):358-61. Affeldt S, Singh PP, Cascone I, Selimoglu R, Camonis J, Isambert H. PMID: 23621930.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    19. On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates. Cell Rep. 2012 Nov 29; 2(5):1387-98. Singh PP, Affeldt S, Cascone I, Selimoglu R, Camonis J, Isambert H. PMID: 23168259.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    20. Case for an RNA-prion world: a hypothesis based on conformational diversity. J Biol Phys. 2011 Mar; 37(2):185-8. Singh PP, Banerji A. PMID: 22379228; PMCID: PMC3047198.
      View in: PubMed   Mentions: 3     Fields:    
    With one click, see people who:

    Mentor Faculty

    Run Clinical Trials

    Work in Global Health Equity

    Offer Student Projects

    See more options in the Advanced Search tab

    Param Priya's Networks
    Concepts (94)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (3)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB03.

    Copyright © The Regents of the University of California.