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Eric Huang, MD, PhD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-221-4810
ORCID ORCID Icon0000-0002-5381-3801 Additional info
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    Collapse Biography 
    Collapse Education and Training
    National Taiwan University School of MedicineMD1986
    Cornell UniversityPhD1993
    University of California, San FranciscoResidency 1995Pathology
    University of California, San FranciscoClinical Fellow1997Neuropathology
    University of California, San FranciscoPost-Doc Scholar2000HHMI & Neuroscience Program
    Collapse Awards and Honors
    Sloan-Kettering Cancer Center1990  - 1991Frank Lappin Horsfall, Jr. Fellowship
    Cornell University1991Vincent du Vigneaud Award of Excellence
    Howard Hughes Medical Institute1997  - 2000Postdoctoral Fellowship for Physicians
    AANP Annual Meeting1998Weil Award for the best paper in Experimental Neuropathology
    Dept of Veterans Affairs1999  - 2002Advanced Career Development Award
    Dept of Veterans Affairs2000  - 2005Presidential Early Career Award for Scientists and Engineers (PECASE)
    NINDS/NIH2002  - 2007Independent Scientist Award
    NCRR/NIH2009  - 2014Mid-career Investigator Award
    Gordon Research Confernece on Molecular & Cellular Neurobiology2012  - 2014Vice Chair (2012) & Chair (2014)
    American Association of Neuropathologists (AANP)2016The DeArmond Lecture
    University of California Davis2017The Stowell Lecture
    UCSF BMS Graduate Program2019BMS Mentoring Award

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist with the unique combination of skills in cellular and molecular neurobiology and diagnostic neuropathology. There are two general areas of research in my laboratory, both supported by extramural funding. The first area focuses on the cellular and molecular mechanisms that govern neural circuit development and function. Another major area of research in my lab focuses on the molecular mechanisms of neurodegenerative diseases, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In addition to our seminal work to investigate disease mechanisms in model organisms, we have made every effort to directly connect our research with human diseases. To this end, I have spearheaded the efforts to establish the UC Pediatric Neuropathology Consortium. The success of this endeavor is underscored by our extensive collaborations with colleagues within and outside UCSF, which lead to many important discoveries. Most importantly, these studies revealed previously unrecognized role of neural circuit dysfunctions in neurodevelopmental and neurodegenerative diseases, and re-define our approaches toward investigating the molecular and cellular pathways in these devastating diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Progranulin deficiency and microglia senescence in neurodegeneration
    NIH/NIA R01AG068290Aug 1, 2020 - Jul 31, 2025
    Role: Principal Investigator
    Single Cell Analyses of Neuroimmune Dysfunctions in the Thalamocortical Circuit in FTLD
    NIH/NIAAA R01AA027074Sep 15, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Autophagy-dependent exosome loading and biogenesis in AD and FTD
    NIH/NIA R01AG057462Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    A Cellular Resolution Census of the Developing Human Brain
    NIH/NIMH U01MH114825Sep 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Mechanisms of Progranulin Deficiency in Neuroinflammation and Neurodegeneration
    VA I01BX002978Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Mechanisms of HIPK2 in neurodegeneration
    NIH/NINDS R01NS098516Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    ER Stress-induced Neurodegeneration as Therapeutic Targets for ALS
    VA I01RX002133Apr 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Regulation of Cellular Pathwaysin Human Brain Development
    NIH/NINDS P01NS083513Jul 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    2014 Molecular and Cellular Neurobiology Gordon Research Conference and Seminar
    NIH/NINDS R13NS087781Apr 15, 2014 - Mar 31, 2015
    Role: Principal Investigator
    Mechanism of FUS Mutations in the Pathogenesis of ALS
    VA I21BX001625Oct 1, 2012 - Sep 30, 2014
    Role: Principal Investigator
    Molecular Analysis of BDNF-TrkB Regulation of Synapse Formation and Maintenance
    NIH/NINDS R01NS081485Sep 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Cellular and Animal Models of FUS Mutations in ALS
    NIH R21OD011915Jul 15, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis
    VA I01BX001108Jul 1, 2011 - Jun 30, 2020
    Role: Principal Investigator
    Hepatitis B Virus PreS2 Mutant as Risk Factor for Hepatocellular Carcinoma
    NIH/NCI RC1CA146279Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Mouse models of neuroprotection in dopamine neurons
    NIH K26OD010927Mar 1, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Mouse models of neuroprotection in dopamine neurons
    NIH/NCRR K26RR024858Mar 1, 2009 - Feb 28, 2014
    Role: Principal Investigator
    New mouse model of hepatitis B virus-associated hepatocellular carcinoma
    NIH/NCRR R21RR024229Sep 1, 2007 - Aug 31, 2010
    Role: Principal Investigator
    Signaling pathways of HIPK2 in neuronal apoptosis
    NIH/NINDS R01NS048393Jan 1, 2005 - Dec 31, 2010
    Role: Principal Investigator
    Molecular Mechanisms of Sensory Neurogenesis
    NIH/NINDS K02NS044223Sep 30, 2002 - Jun 30, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Aug 31. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962.
      View in: PubMed   Mentions:    Fields:    
    2. A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature. J Neurosci. 2020 Aug 19; 40(34):6503-6521. Mondo E, Becker SC, Kautzman AG, Schifferer M, Baer CE, Chen J, Huang EJ, Simons M, Schafer DP. PMID: 32661024.
      View in: PubMed   Mentions:    Fields:    
    3. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10565-10574. Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC. PMID: 32345721.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides. Hum Mol Genet. 2020 Mar 13; 29(4):624-634. Kuang L, Hashimoto K, Huang EJ, Gentry MS, Zhu H. PMID: 31913476.
      View in: PubMed   Mentions: 1     Fields:    
    5. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover. J Neurosci. 2020 01 15; 40(3):557-568. Zhang J, Shang Y, Kamiya S, Kotowski SJ, Nakamura K, Huang EJ. PMID: 31776210.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia. Brain Commun. 2019; 1(1):fcz027. Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 32699834.
      View in: PubMed   Mentions:
    8. C9orf72-specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregation. Acta Neuropathol. 2019 12; 138(6):1093-1097. Sampognaro PJ, Vatsavayai SC, Cosme CG, Hwang JL, Nolan A, Huang EJ, Seeley WW, De May MG. PMID: 31624869.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy. Am J Med Genet A. 2019 12; 179(12):2486-2489. Vandeleur D, Chen CV, Huang EJ, Connolly AJ, Sanchez H, Moon-Grady AJ. PMID: 31587467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies. Brain. 2019 07 01; 142(7):2068-2081. Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW. PMID: 31081015.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019 06 21; 10(1):2748. Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A. PMID: 31227709.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Impaired aVß8 and TGFß signaling lead to microglial dysmaturation and neuromotor dysfunction. J Exp Med. 2019 04 01; 216(4):900-915. Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. PMID: 30846482.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Does Adult Neurogenesis Persist in the Human Hippocampus? Cell Stem Cell. 2018 12 06; 23(6):780-781. Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. PMID: 30526879.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol. 2019 01; 137(1):27-46. Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW. PMID: 30511086.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration. Annu Rev Pathol. 2019 01 24; 14:469-495. Hofmann JW, Seeley WW, Huang EJ. PMID: 30355151.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 10; 277:145-154. Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. PMID: 30212683.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death. J Neurosci. 2018 04 18; 38(16):4006-4019. Shang Y, Zhang J, Huang EJ. PMID: 29581378.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 03 15; 555(7696):377-381. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. PMID: 29513649.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    19. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. PMID: 29511098.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. 2018 03 20; 90(12):e1047-e1056. Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski JQ, Miller BL, Seeley WW. PMID: 29453245.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 2017 Dec 01; 140(12):3329-3345. Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. PMID: 29053860.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    22. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    24. An RNA interference screen identifies druggable regulators of MeCP2 stability. Sci Transl Med. 2017 Aug 23; 9(404). Lombardi LM, Zaghlula M, Sztainberg Y, Baker SA, Klisch TJ, Tang AA, Huang EJ, Zoghbi HY. PMID: 28835516.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16; 9(403). Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW. PMID: 28814543.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    26. Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia. Neural Dev. 2017 May 08; 12(1):7. Rakotomamonjy J, Brunner M, Jüschke C, Zang K, Huang EJ, Reichardt LF, Chenn A. PMID: 28482867.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Precipitous Deterioration of Motor Function, Cognition, and Behavior. JAMA Neurol. 2017 05 01; 74(5):591-596. Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD. PMID: 28264087.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Progranulin, lysosomal regulation and neurodegenerative disease. Nat Rev Neurosci. 2017 06; 18(6):325-333. Kao AW, McKay A, Singh PP, Brunet A, Huang EJ. PMID: 28435163.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    29. Long-term oral kinetin does not protect against a-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017 Oct; 109:106-116. Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K. PMID: 28434973.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Sci Transl Med. 2017 04 12; 9(385). Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ. PMID: 28404863.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    31. Typical and atypical pathology in primary progressive aphasia variants. Ann Neurol. 2017 Mar; 81(3):430-443. Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 28133816.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    32. Testing the Amyloid Hypothesis with a Humanized AD Mouse Model. Neuron. 2017 Mar 08; 93(5):987-989. Cahill MK, Huang EJ. PMID: 28279360.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    33. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 01 10; 6. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. PMID: 28072389.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. TGF-ß Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Rep. 2016 12 20; 17(12):3233-3245. Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ. PMID: 28009292.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308). Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. PMID: 27846470.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    36. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. PMID: 27321923.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    37. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. PMID: 27114033.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    38. Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis. Brain Res. 2016 09 15; 1647:65-78. Shang Y, Huang EJ. PMID: 27033831.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    39. Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia. Cereb Cortex. 2016 Apr; 26(4):1843. Kim EJ, Sidhu M, Gaus SE, Huang EJ, Hof PR, Miller BL, DeArmond SJ, Seeley WW. PMID: 26796215.
      View in: PubMed   Mentions: 2     Fields:    
    40. Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. Am J Pathol. 2016 Mar; 186(3):478-88. Luo SX, Huang EJ. PMID: 26724386.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    41. Ventral midbrain dopaminergic neurons: From neurogenesis to neurodegeneration. FEBS Lett. 2015 Dec 21; 589(24 Pt A):3691-2. Huang EJ. PMID: 26581860.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    42. Modeling ALS and FTD with iPSC-derived neurons. Brain Res. 2017 02 01; 1656:88-97. Lee S, Huang EJ. PMID: 26462653.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    43. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science. 2015 Oct 02; 350(6256):102-6. Kim JI, Ganesan S, Luo SX, Wu YW, Park E, Huang EJ, Chen L, Ding JB. PMID: 26430123.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    44. Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol. 2015 Sep; 37(9):470-8. Fontana MF, Baccarella A, Kellar D, Oniskey TK, Terinate P, Rosenberg SD, Huang EJ, Herbert DR, Kim CC. PMID: 26178310.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series. Neurol Clin Pract. 2015 Aug; 5(4):285-295. Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD. PMID: 26336629.
      View in: PubMed   Mentions:
    46. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain. 2015 Sep; 138(Pt 9):2732-49. Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. PMID: 26141491.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    47. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7821-6. Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S. PMID: 26056265.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    48. Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome. Acta Neuropathol. 2015 Aug; 130(2):171-83. Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ. PMID: 25975378.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
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    115. Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development. 2001 Jul; 128(13):2421-32. Huang EJ, Liu W, Fritzsch B, Bianchi LM, Reichardt LF, Xiang M. PMID: 11493560.
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    116. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001 Feb; 128(3):417-26. Kim WY, Fritzsch B, Serls A, Bakel LA, Huang EJ, Reichardt LF, Barth DS, Lee JE. PMID: 11152640.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    117. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001; 24:677-736. Huang EJ, Reichardt LF. PMID: 11520916.
      View in: PubMed   Mentions: 989     Fields:    Translation:HumansAnimalsCells
    118. Formation of a full complement of cranial proprioceptors requires multiple neurotrophins. Dev Dyn. 2000 Jun; 218(2):359-70. Fan G, Copray S, Huang EJ, Jones K, Yan Q, Walro J, Jaenisch R, Kucera J. PMID: 10842362.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    119. POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development. 1999 Jul; 126(13):2869-82. Huang EJ, Zang K, Schmidt A, Saulys A, Xiang M, Reichardt LF. PMID: 10357931.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    120. Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999 May; 126(10):2191-203. Huang EJ, Wilkinson GA, Fariñas I, Backus C, Zang K, Wong SL, Reichardt LF. PMID: 10207144.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    121. Role of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis. J Exp Med. 1998 May 04; 187(9):1451-61. Tajima Y, Huang EJ, Vosseller K, Ono M, Moore MA, Besmer P. PMID: 9565637.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    122. Hepatitis B and C coinfections and persistent hepatitis B infections: clinical outcome and liver pathology after transplantation. Hepatology. 1996 Mar; 23(3):396-404. Huang EJ, Wright TL, Lake JR, Combs C, Ferrell LD. PMID: 8617417.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    123. The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia. Dev Biol. 1993 May; 157(1):85-99. Manova K, Huang EJ, Angeles M, De Leon V, Sanchez S, Pronovost SM, Besmer P, Bachvarova RF. PMID: 7683286.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    124. The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles. Dev Biol. 1993 May; 157(1):100-9. Huang EJ, Manova K, Packer AI, Sanchez S, Bachvarova RF, Besmer P. PMID: 7683280.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    125. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993; 125-37. Besmer P, Manova K, Duttlinger R, Huang EJ, Packer A, Gyssler C, Bachvarova RF. PMID: 7519481.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    126. c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons. J Neurosci. 1992 Dec; 12(12):4663-76. Manova K, Bachvarova RF, Huang EJ, Sanchez S, Pronovost SM, Velazquez E, McGuire B, Besmer P. PMID: 1281492.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    127. Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. J Biol Chem. 1992 Nov 25; 267(33):24028-33. Pandiella A, Bosenberg MW, Huang EJ, Besmer P, Massagué J. PMID: 1385433.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    128. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell. 1992 Mar; 3(3):349-62. Huang EJ, Nocka KH, Buck J, Besmer P. PMID: 1378327.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    129. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990 Oct 05; 63(1):225-33. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P. PMID: 1698557.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
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