Paul Ortiz De Montellano, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St, #408A
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Massachusetts Institute of TechnologyB.S.1964Chemistry
    Harvard UniversityM.A., Ph.D.1968Chemistry
    Eidgenossische Technische Hochschule, ZurichPostdoc1969Chemistry

    Collapse Overview 
    Collapse Overview
    Heme-containing proteins are critical for the function of essentially all life forms. In humans, they are involved in respiration, the synthesis of hormones and other vital molecules, the elimination of drugs, and various signaling pathways. My laboratory has investigated the structure, mechanism, biochemistry and role of heme proteins for many years. We have focused particularly on the human cytochrome P450, peroxidase, and heme oxygenase enzymes. Our contributions in this area include crystal structures of bacterial P450 enzymes and the human heme oxygenase, clarification of the mechanism of cytochrome P450 enzymes, the development of methods for the mechanism-based inactivation of P450 enzymes, and more recently studies of human cytochrome P450 enzymes that are selectively expressed in cancer cells and are potentially useful in the activation of anticancer drugs. We currently also work on two classes of heme proteins in Mycobacterium tuberculosis, the causative agent of tuberculosis: (a) the twenty cytochrome P450 enzymes, some of which potential targets for anti-tuberculosis drugs, and (b) the gas sensor that initiates the dormant, persistent stage of tuberculosis that is difficult to eradicate and which can be reactivated when the immune system is compromised.

    The studies in my laboratory employ a diversity of techniques, including organic synthesis, molecular biology, enzymology, and multiple spectroscopic techniques. We frequently collaborate with laboratories that have complementary expertise in organic synthesis, X-ray crystallography, NMR, or resonance Raman spectroscopy.

    Collapse Research 
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    Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis
    NIH R01AI074824Sep 1, 2007 - Jan 31, 2019
    Role: Principal Investigator
    NIH R13DK058032Jul 1, 2000 - Jun 30, 2001
    Role: Principal Investigator
    Structure Biology and Targeted Drug Design for AIDS
    NIH P01GM056531Sep 1, 1997 - Aug 31, 2007
    Role: Principal Investigator
    NIH P01GM039552Sep 1, 1987 - Aug 31, 1997
    Role: Co-Investigator
    NIH P30AM026743Jul 1, 1985 - Jun 30, 1990
    Role: Co-Investigator
    NIH R01GM032488Jul 1, 1983 - Jun 30, 2009
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Hemoprotein Oxidation and Heme Catabolism
    NIH R01DK030297Jan 1, 1982 - Jun 30, 2014
    Role: Principal Investigator
    NIH R01AM030297Jan 1, 1982 - Dec 31, 1989
    Role: Principal Investigator
    Mechanism, Specificity, and Inhibition of Cytochrome P450
    NIH R01GM025515Jul 1, 1978 - Jun 30, 2016
    Role: Principal Investigator
    NIH R37GM025515Jul 1, 1978 - Jun 30, 1999
    Role: Principal Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system. J Inorg Biochem. 2018 03; 180:235-245. Ortiz de Montellano PR. PMID: 29352597; PMCID: PMC5801126.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    2. Heme and I. J Biol Chem. 2015 Sep 04; 290(36):21833-44. Ortiz de Montellano PR. PMID: 26195628; PMCID: PMC4571939.
      View in: PubMed   Mentions: 1     Fields:    
    3. Cytochrome P450-activated prodrugs. Future Med Chem. 2013 Feb; 5(2):213-28. Ortiz de Montellano PR. PMID: 23360144; PMCID: PMC3697796.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    4. Mechanism and role of covalent heme binding in the CYP4 family of P450 enzymes and the mammalian peroxidases. Drug Metab Rev. 2008; 40(3):405-26. Ortiz de Montellano PR. PMID: 18642140.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    5. The mechanism of heme oxygenase. Curr Opin Chem Biol. 2000 Apr; 4(2):221-7. Montellano PR. PMID: 10742194.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    6. Nitric oxide synthase structure and electron transfer. Drug Metab Dispos. 1998 Dec; 26(12):1185-9. Ortiz de Montellano PR, Nishida C, Rodriguez-Crespo I, Gerber N. PMID: 9860925.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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