Almira Correia, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street, #N572F
San Francisco CA 94158
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    As a Professor in the Cellular Molecular Pharmacology department at UCSF, my research has been centered on the elucidation of key molecular mechanisms involved in the function and regulation of hepatic cytochrome P450 enzymes (P450s) and other physiologically important hemoproteins. Through extensive publications, we have investigated the structural determinants and regulatory pathways that govern the function and degradation of these enzymes. Our work on the other hemoproteins has also enabled us to shed light on the role of p62 in limiting NF-kB activation through stabilization of IkBa, the NF-kB-inhibitor, and to elucidate the underlying cause for inflammation in hepatic Mallory-Denk-Body induced conditions. Additionally, we have explored the therapeutic and pathophysiological aspects of impaired P450 degradation, and the consequent hepatic CYP2E1 elevation and its causal association with NAFLD/NASH. As the Principal Investigator on several NIH-sponsored projects, I have contributed significantly to advancing our understanding of hepatic cytochrome P450 enzymes and their regulation, opening up potential avenues for therapeutic interventions.
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    Collapse Research Activities and Funding
    Hepatic degradation of cytochrome P450 enzymes
    NIH R01GM044037Apr 1, 1990 - May 31, 2019
    Role: Principal Investigator
    NIH R13DK040470May 1, 1988 - Apr 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Influence of Heme on Hepatic Cytochrome P450 Turnover
    NIH R01DK026506Jul 1, 1980 - Mar 31, 2017
    Role: Principal Investigator
    Influence of Heme on Hepatic Cytochrome P450 Synthesis and Degradation
    NIH R56DK026506Jul 1, 1980 - Jun 30, 2008
    Role: Principal Investigator
    NIH R01AM026506Jul 1, 1980 - Jun 30, 1986
    Role: Principal Investigator
    NIH P41RR000480Jan 1, 1978 - Nov 30, 1999
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization. Mol Cell Proteomics. 2023 02; 22(2):100495. Liu Y, Trnka MJ, He L, Burlingame AL, Correia MA. PMID: 36634736; PMCID: PMC9947424.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase. Biochem J. 2021 05 28; 478(10):1999-2017. Liu Y, Kim SM, Wang Y, Karkashon S, Lewis-Ballester A, Yeh SR, Correia MA. PMID: 33960368; PMCID: PMC8892992.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models. Biology (Basel). 2020 Nov 26; 9(12). Correia MA, Kwon D. PMID: 33255949; PMCID: PMC7760898.
      View in: PubMed   Mentions: 9  
    4. A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation. Mol Cell Proteomics. 2020 12; 19(12):1968-1986. Liu Y, Trnka MJ, Guan S, Kwon D, Kim DH, Chen JJ, Greer PA, Burlingame AL, Correia MA. PMID: 32912968; PMCID: PMC7710137.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707; PMCID: PMC7147832.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansCells
    6. Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. Acta Pharm Sin B. 2020 Jan; 10(1):42-60. Kwon D, Kim SM, Correia MA. PMID: 31993306; PMCID: PMC6976991.
      View in: PubMed   Mentions: 15  
    7. Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance. Mol Pharmacol. 2019 11; 96(5):641-654. Kwon D, Kim SM, Jacob P, Liu Y, Correia MA. PMID: 31492698; PMCID: PMC6790065.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep. 2016 10 20; 6:35169. Lewis-Ballester A, Forouhar F, Kim SM, Lew S, Wang Y, Karkashon S, Seetharaman J, Batabyal D, Chiang BY, Hussain M, Correia MA, Yeh SR, Tong L. PMID: 27762317; PMCID: PMC5071832.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    9. CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications. Sci Rep. 2016 07 12; 6:29423. Kim SM, Grenert JP, Patterson C, Correia MA. PMID: 27406999; PMCID: PMC4942616.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. Drug Metab Rev. 2016 08; 48(3):405-33. Kim SM, Wang Y, Nabavi N, Liu Y, Correia MA. PMID: 27320797; PMCID: PMC5094896.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes. J Biol Chem. 2015 Feb 06; 290(6):3308-32. Wang Y, Kim SM, Trnka MJ, Liu Y, Burlingame AL, Correia MA. PMID: 25451919; PMCID: PMC4319004.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    12. Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition? IUBMB Life. 2014 Feb; 66(2):78-88. Correia MA, Wang Y, Kim SM, Guan S. PMID: 24488826; PMCID: PMC3959620.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction. Mol Cell Proteomics. 2012 Feb; 11(2):M111.010132. Wang Y, Guan S, Acharya P, Liu Y, Thirumaran RK, Brandman R, Schuetz EG, Burlingame AL, Correia MA. PMID: 22101235; PMCID: PMC3277751.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    14. Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. J Biol Chem. 2011 Mar 18; 286(11):9443-56. Wang Y, Guan S, Acharya P, Koop DR, Liu Y, Liao M, Burlingame AL, Correia MA. PMID: 21209460; PMCID: PMC3058980.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol. J Biol Chem. 2011 Feb 04; 286(5):3815-28. Acharya P, Liao M, Engel JC, Correia MA. PMID: 21107009; PMCID: PMC3030383.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    16. Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metab Rev. 2011 Feb; 43(1):1-26. Correia MA, Sinclair PR, De Matteis F. PMID: 20860521; PMCID: PMC3034403.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    17. Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. J Biol Chem. 2010 Nov 12; 285(46):35866-77. Kim SM, Acharya P, Engel JC, Correia MA. PMID: 20819951; PMCID: PMC2975210.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    18. Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol. 2010 Apr; 77(4):575-92. Acharya P, Chen JJ, Correia MA. PMID: 20071449; PMCID: PMC2845940.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff. Mol Pharmacol. 2009 Sep; 76(3):503-15. Acharya P, Engel JC, Correia MA. PMID: 19520899; PMCID: PMC2730383.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation. J Biol Chem. 2009 Feb 27; 284(9):5671-84. Wang Y, Liao M, Hoe N, Acharya P, Deng C, Krutchinsky AN, Correia MA. PMID: 19095658; PMCID: PMC2645824.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    21. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch Biochem Biophys. 2009 Mar 01; 483(1):66-74. Pabarcus MK, Hoe N, Sadeghi S, Patterson C, Wiertz E, Correia MA. PMID: 19103148; PMCID: PMC2881844.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    22. Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metab Dispos. 2008 Aug; 36(8):1637-49. Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS. PMID: 18463198; PMCID: PMC2562787.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    23. CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile. Drug Metab Dispos. 2008 Mar; 36(3):490-9. Kang P, Liao M, Wester MR, Leeder JS, Pearce RE, Correia MA. PMID: 18096676; PMCID: PMC2881839.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    24. Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor. J Pharmacol Exp Ther. 2007 Dec; 323(3):979-89. Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA. PMID: 17761498.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    25. Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? Biochemistry. 2007 Jul 03; 46(26):7793-803. Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA. PMID: 17550236; PMCID: PMC2536616.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver. Expert Opin Drug Metab Toxicol. 2007 Feb; 3(1):33-49. Correia MA, Liao M. PMID: 17269893.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    27. Endoplasmic reticulum-associated degradation of cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: further characterization of cellular participants and structural determinants. Mol Pharmacol. 2006 Jun; 69(6):1897-904. Liao M, Faouzi S, Karyakin A, Correia MA. PMID: 16556771.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    28. Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase? J Pharmacol Exp Ther. 2005 Jul; 314(1):128-38. Han XM, Lee G, Hefner C, Maher JJ, Correia MA. PMID: 15769864.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins. Mol Pharmacol. 2005 May; 67(5):1460-9. Liao M, Zgoda VG, Zgoda VA, Murray BP, Correia MA. PMID: 15703377.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Cytochrome P450 ubiquitination: branding for the proteolytic slaughter? Annu Rev Pharmacol Toxicol. 2005; 45:439-64. Correia MA, Sadeghi S, Mundo-Paredes E. PMID: 15822184.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    31. Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade. Drug Metab Rev. 2003 May-Aug; 35(2-3):107-43. Correia MA. PMID: 12959413.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. The changing environment of graduate and postdoctoral training in drug metabolism: viewpoints from academia, industry, and government. Drug Metab Dispos. 2003 Apr; 31(4):360-6. Stevens JC, Dean DC, Preusch PC, Correia MA. PMID: 12642460.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase. Arch Biochem Biophys. 2003 Jan 01; 409(1):113-26. Xue L, Zgoda VG, Arison B, Correia MA. PMID: 12464250.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly. Arch Biochem Biophys. 2002 Dec 01; 408(1):58-68. Gavrilovich Zgoda V, Arison B, Mkrtchian S, Ingelman-Sundberg M, Correia MA. PMID: 12485603.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4. Drug Metab Dispos. 2002 Sep; 30(9):985-90. Khan KK, He YQ, Correia MA, Halpert JR. PMID: 12167563.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    36. Alcohol use and HIV pharmacotherapy. AIDS Res Hum Retroviruses. 2002 Jul 20; 18(11):757-70. Kresina TF, Flexner CW, Sinclair J, Correia MA, Stapleton JT, Adeniyi-Jones S, Cargill V, Cheever LW. PMID: 12167267.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    37. Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein. Mol Pharmacol. 2002 May; 61(5):1146-53. Murray BP, Zgoda VG, Correia MA. PMID: 11961133.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    38. Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides. Biochemistry. 2001 Sep 25; 40(38):11318-26. Wang X, Medzihradszky KF, Maltby D, Correia MA. PMID: 11560479.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    39. Ubiquitin-dependent 26S proteasomal pathway: a role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae? Arch Biochem Biophys. 2001 Sep 01; 393(1):106-16. Murray BP, Correia MA. PMID: 11516167.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    40. Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues. Arch Biochem Biophys. 2001 Aug 01; 392(1):71-8. Dick R, Murray BP, Reid MJ, Correia MA. PMID: 11469796.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    41. Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation. Chem Res Toxicol. 2001 May; 14(5):483-91. Xue L, Wang HF, Wang Q, Szklarz GD, Domanski TL, Halpert JR, Correia MA. PMID: 11368545.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    42. Heme: a regulator of rat hepatic tryptophan 2,3-dioxygenase? Arch Biochem Biophys. 2000 May 01; 377(1):195-203. Ren S, Correia MA. PMID: 10775460.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    43. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos. 1999 Dec; 27(12):1505-11. Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. PMID: 10570034.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome? Arch Biochem Biophys. 1999 May 01; 365(1):31-44. Korsmeyer KK, Davoll S, Figueiredo-Pereira ME, Correia MA. PMID: 10222036.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes. Arch Biochem Biophys. 1999 May 01; 365(1):45-53. Wang HF, Figueiredo Pereira ME, Correia MA. PMID: 10222037.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    46. Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4. Biochemistry. 1998 Dec 15; 37(50):17448-57. He K, Bornheim LM, Falick AM, Maltby D, Yin H, Correia MA. PMID: 9860860.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    47. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. Biochemistry. 1998 Sep 08; 37(36):12536-45. Wang H, Dick R, Yin H, Licad-Coles E, Kroetz DL, Szklarz G, Harlow G, Halpert JR, Correia MA. PMID: 9730826.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    48. Cytochrome P450 2C11: Escherichia coli expression, purification, functional characterization, and mechanism-based inactivation of the enzyme. Arch Biochem Biophys. 1997 Feb 01; 338(1):35-42. Licad-Coles E, He K, Yin H, Correia MA. PMID: 9015385.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    49. Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation. J Biol Chem. 1996 Oct 18; 271(42):25864-72. He K, He YA, Szklarz GD, Halpert JR, Correia MA. PMID: 8824218.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    50. Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme. Arch Biochem Biophys. 1996 Sep 01; 333(1):96-102. Ren S, Liu H, Licad E, Correia MA. PMID: 8806758.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital. Chem Res Toxicol. 1996 Apr-May; 9(3):614-22. He K, Falick AM, Chen B, Nilsson F, Correia MA. PMID: 8728507.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    52. Microsomal cytochrome P450-mediated liver and brain anandamide metabolism. Biochem Pharmacol. 1995 Aug 25; 50(5):677-86. Bornheim LM, Kim KY, Chen B, Correia MA. PMID: 7669071.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    53. Interactions of peroxyquinols with cytochromes P450 2B1, 3A1, and 3A5: influence of the apoprotein on heterolytic versus homolytic O-O bond cleavage. Arch Biochem Biophys. 1995 Mar 10; 317(2):471-8. Correia MA, Yao K, Allentoff AJ, Wrighton SA, Thompson JA. PMID: 7893165.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Cobaltous chloride-mediated induction of rat hepatic tryptophan 2,3-dioxygenase: implications for the use of the enzyme to probe the hepatic free heme pool. Cell Mol Biol (Noisy-le-grand). 1994 Nov; 40(7):881-9. Liu H, Correia MA. PMID: 7849555.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    55. pH-dependent one- and two-electron oxidation of 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine catalyzed by horseradish peroxidase. Chem Res Toxicol. 1994 Sep-Oct; 7(5):633-42. Sugiyama K, Correia MA, Thummel KE, Nagata K, Darbyshire JF, Osawa Y, Gillette JR. PMID: 7841342.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    56. Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol. Biochem Pharmacol. 1994 Jul 05; 48(1):161-71. Bornheim LM, Everhart ET, Li J, Correia MA. PMID: 8043019.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    57. Selective inhibitors of cytochromes P450. Toxicol Appl Pharmacol. 1994 Apr; 125(2):163-75. Halpert JR, Guengerich FP, Bend JR, Correia MA. PMID: 8171425.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    58. The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism. Biochem Biophys Res Commun. 1993 Dec 15; 197(2):740-6. Bornheim LM, Kim KY, Chen B, Correia MA. PMID: 8267610.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    59. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Drug Metab Dispos. 1993 Jul-Aug; 21(4):730-7. Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ. PMID: 8104135.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Biochem Pharmacol. 1993 Mar 24; 45(6):1323-31. Bornheim LM, Everhart ET, Li J, Correia MA. PMID: 8466552.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    61. Cumene hydroperoxide-mediated inactivation of cytochrome P450 2B1. Identification of an active site heme-modified peptide. J Biol Chem. 1993 Jan 05; 268(1):59-65. Yao K, Falick AM, Patel N, Correia MA. PMID: 8416964.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    62. Matrix-assisted laser desorption mass spectrometry of cytochromes P450. Rapid Commun Mass Spectrom. 1993 Jan; 7(1):16-9. Lewis S, Korsmeyer KK, Correia MA. PMID: 8428024.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    63. Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: characterization of the proteolytic system. Arch Biochem Biophys. 1992 Sep; 297(2):228-38. Correia MA, Davoll SH, Wrighton SA, Thomas PE. PMID: 1497342.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    64. Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms? Arch Biochem Biophys. 1992 May 01; 294(2):493-503. Correia MA, Yao K, Wrighton SA, Waxman DJ, Rettie AE. PMID: 1567205.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    65. Specifically designed thiosteroids as active-site-directed probes for functional dissection of rat liver cytochrome P450 3A isozymes. Chem Res Toxicol. 1992 Jan-Feb; 5(1):42-53. Underwood MC, Cashman JR, Correia MA. PMID: 1581535.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    66. Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: a functional probe of two-electron oxidations of the thiosteroid? Chem Res Toxicol. 1991 Nov-Dec; 4(6):669-77. Decker CJ, Cashman JR, Sugiyama K, Maltby D, Correia MA. PMID: 1807450.
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    67. Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily. Mol Pharmacol. 1991 Aug; 40(2):228-34. Bornheim LM, Correia MA. PMID: 1875910.
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    68. Cytochrome P450 turnover. Methods Enzymol. 1991; 206:315-25. Correia MA. PMID: 1784218.
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    70. Inactivation of rat hepatic cytochrome P-450 isozymes by 3,5-dicarbethoxy- 2,6-dimethyl-4-ethyl-1,4-dihydropyridine. Chem Res Toxicol. 1989 Nov-Dec; 2(6):400-10. Sugiyama K, Yao K, Rettie AE, Correia MA. PMID: 2519730.
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    72. Purification and characterization of a mouse liver cytochrome P-450 induced by cannabidiol. Mol Pharmacol. 1989 Sep; 36(3):377-83. Bornheim LM, Correia MA. PMID: 2779523.
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    73. Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450. Biochemistry. 1989 Jun 13; 28(12):5128-36. Decker CJ, Rashed MS, Baillie TA, Maltby D, Correia MA. PMID: 2765527.
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    74. Acute hepatic heme depletion: impaired gluconeogenesis in rats. Semin Hematol. 1989 Apr; 26(2):120-7. Correia MA, Lunetta JM. PMID: 2471273.
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    75. Secobarbital-mediated inactivation of rat liver cytochrome P-450b: a mechanistic reappraisal. Mol Pharmacol. 1989 Jan; 35(1):10-7. Lunetta JM, Sugiyama K, Correia MA. PMID: 2913483.
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    77. Role of gastrin/pentagastrin in regulation of intestinal cytochrome P-450. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988; 90(1):41-6. Pascoe GA, Correia MA. PMID: 2904872.
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    78. Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts. Arch Biochem Biophys. 1987 Nov 01; 258(2):436-51. Correia MA, Decker C, Sugiyama K, Caldera P, Bornheim L, Wrighton SA, Rettie AE, Trager WF. PMID: 3674884.
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    79. Inactivation of multiple hepatic cytochrome P-450 isozymes in rats by allylisopropylacetamide: mechanistic implications. Mol Pharmacol. 1987 Aug; 32(1):299-308. Bornheim LM, Underwood MC, Caldera P, Rettie AE, Trager WF, Wrighton SA, Correia MA. PMID: 3302670.
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    80. Drug-induced modulations of hepatic heme metabolism. Neurological consequences. Ann N Y Acad Sci. 1987; 514:248-55. Correia MA, Litman DA, Lunetta JM. PMID: 3442388.
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    81. Fractionation and purification of hepatic microsomal cytochrome P-450 isoenzymes from phenobarbital-pretreated rats by h.p.l.c. A convenient tool for screening of isoenzymes inactivated by allylisopropylacetamide. Biochem J. 1986 Nov 01; 239(3):661-9. Bornheim LM, Correia MA. PMID: 3827818; PMCID: PMC1147337.
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