As a Professor in the Cellular Molecular Pharmacology department at UCSF, my research has been centered on the elucidation of key molecular mechanisms involved in the function and regulation of hepatic cytochrome P450 enzymes (P450s) and other physiologically important hemoproteins. Through extensive publications, we have investigated the structural determinants and regulatory pathways that govern the function and degradation of these enzymes. Our work on the other hemoproteins has also enabled us to shed light on the role of p62 in limiting NF-kB activation through stabilization of IkBa, the NF-kB-inhibitor, and to elucidate the underlying cause for inflammation in hepatic Mallory-Denk-Body induced conditions. Additionally, we have explored the therapeutic and pathophysiological aspects of impaired P450 degradation, and the consequent hepatic CYP2E1 elevation and its causal association with NAFLD/NASH. As the Principal Investigator on several NIH-sponsored projects, I have contributed significantly to advancing our understanding of hepatic cytochrome P450 enzymes and their regulation, opening up potential avenues for therapeutic interventions.