Phosphodiesterase Inhibitors
"Phosphodiesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
| Descriptor ID |
D010726
|
| MeSH Number(s) |
D27.505.519.389.735
|
| Concept/Terms |
Phosphodiesterase Inhibitors- Phosphodiesterase Inhibitors
- Phosphodiesterase Antagonists
- Phosphoric Diester Hydrolase Inhibitors
- Antiphosphodiesterases
|
Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase Inhibitors".
This graph shows the total number of publications written about "Phosphodiesterase Inhibitors" by people in this website by year, and whether "Phosphodiesterase Inhibitors" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 2 | 4 |
| 1997 | 1 | 3 | 4 |
| 1998 | 1 | 4 | 5 |
| 1999 | 5 | 7 | 12 |
| 2000 | 7 | 8 | 15 |
| 2001 | 5 | 10 | 15 |
| 2002 | 7 | 3 | 10 |
| 2003 | 12 | 11 | 23 |
| 2004 | 10 | 7 | 17 |
| 2005 | 17 | 13 | 30 |
| 2006 | 16 | 6 | 22 |
| 2007 | 5 | 5 | 10 |
| 2008 | 9 | 11 | 20 |
| 2009 | 10 | 10 | 20 |
| 2010 | 14 | 5 | 19 |
| 2011 | 3 | 5 | 8 |
| 2012 | 6 | 5 | 11 |
| 2013 | 2 | 3 | 5 |
| 2014 | 7 | 2 | 9 |
| 2015 | 1 | 2 | 3 |
| 2016 | 4 | 2 | 6 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 3 | 5 |
| 2020 | 0 | 2 | 2 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 3 | 3 |
| 2024 | 2 | 5 | 7 |
| 2025 | 1 | 0 | 1 |
Below are the most recent publications written about "Phosphodiesterase Inhibitors" by people in Profiles.
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A Neuroimmune Modulator for Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2025 04 01; 8(4):e257523.
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Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024 Dec 06; 10(49):eadq1383.
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Inhibition of Phosphodiesterase 10A Alleviates Pain-like Behavior in Mice. Anesthesiology. 2025 Feb 01; 142(2):332-348.
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Update on the pharmacological treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2024 Oct; 25(14):1903-1922.
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Molecular docking studies, DFT, and ADMET calculations of some flavonoids and their characteristic structural features involved in inhibition of pro-inflammatory enzymes. Nat Prod Res. 2025 Sep; 39(18):5289-5299.
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Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice. Geroscience. 2024 Oct; 46(5):5191-5202.
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Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis. Eur Respir Rev. 2024 Apr; 33(172).
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Effects of PDE10A inhibitor MK-8189 in people with an acute episode of schizophrenia: A randomized proof-of-concept clinical trial. Schizophr Res. 2024 08; 270:37-43.
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Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential. mBio. 2024 Feb 14; 15(2):e0305623.
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Phosphodiesterase in heart and vessels: from physiology to diseases. Physiol Rev. 2024 Apr 01; 104(2):765-834.