"Protease Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
| Descriptor ID |
D011480
|
| MeSH Number(s) |
D27.505.519.389.745
|
| Concept/Terms |
Protease Inhibitors- Protease Inhibitors
- Inhibitors, Protease
- Endopeptidase Inhibitors
- Inhibitors, Endopeptidase
- Protease Inhibitor
- Inhibitor, Protease
- Peptide Hydrolase Inhibitors
- Hydrolase Inhibitors, Peptide
- Inhibitors, Peptide Hydrolase
- Peptide Peptidohydrolase Inhibitors
- Inhibitors, Peptide Peptidohydrolase
- Peptidohydrolase Inhibitors, Peptide
- Protease Antagonists
- Antagonists, Protease
- Antiproteases
- Peptidase Inhibitors
- Inhibitors, Peptidase
|
Below are MeSH descriptors whose meaning is more general than "Protease Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Protease Inhibitors".
This graph shows the total number of publications written about "Protease Inhibitors" by people in this website by year, and whether "Protease Inhibitors" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 6 | 9 |
| 1997 | 5 | 8 | 13 |
| 1998 | 7 | 9 | 16 |
| 1999 | 6 | 15 | 21 |
| 2000 | 5 | 10 | 15 |
| 2001 | 6 | 8 | 14 |
| 2002 | 7 | 6 | 13 |
| 2003 | 17 | 7 | 24 |
| 2004 | 22 | 16 | 38 |
| 2005 | 20 | 12 | 32 |
| 2006 | 14 | 9 | 23 |
| 2007 | 9 | 12 | 21 |
| 2008 | 17 | 12 | 29 |
| 2009 | 18 | 6 | 24 |
| 2010 | 13 | 12 | 25 |
| 2011 | 17 | 13 | 30 |
| 2012 | 13 | 15 | 28 |
| 2013 | 10 | 7 | 17 |
| 2014 | 6 | 7 | 13 |
| 2015 | 5 | 5 | 10 |
| 2016 | 6 | 4 | 10 |
| 2017 | 8 | 5 | 13 |
| 2018 | 9 | 3 | 12 |
| 2019 | 5 | 4 | 9 |
| 2020 | 9 | 5 | 14 |
| 2021 | 7 | 9 | 16 |
| 2022 | 4 | 9 | 13 |
| 2023 | 0 | 18 | 18 |
| 2024 | 1 | 7 | 8 |
| 2025 | 8 | 2 | 10 |
Below are the most recent publications written about "Protease Inhibitors" by people in Profiles.
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Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease. J Virol. 2025 Oct 23; 99(10):e0065825.
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Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity. J Med Chem. 2025 Sep 25; 68(18):19339-19376.
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CROI 2025: Acute and Postacute COVID-19. Top Antivir Med. 2025 Jun 30; 33(3):555-568.
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Computational and Experimental Study of the Conformational Variation of the Catalytic Residue His41 of the SARS-CoV-2 Main Protease. J Phys Chem B. 2025 May 29; 129(21):5198-5206.
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Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy. Sci Adv. 2025 04 25; 11(17):eadt7836.
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On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents. J Med Chem. 2025 May 08; 68(9):9623-9637.
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Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in Salinispora. Mar Drugs. 2025 Mar 14; 23(3).
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Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease. J Med Chem. 2025 Apr 10; 68(7):7003-7030.
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Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity. J Med Chem. 2025 Feb 13; 68(3):3626-3652.
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Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 2025 01 02; 16(1):152.