"Cathepsin L" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
| Descriptor ID |
D056668
|
| MeSH Number(s) |
D08.811.277.656.224.407 D08.811.277.656.262.500.157 D08.811.277.656.300.200.157
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin L".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin L".
This graph shows the total number of publications written about "Cathepsin L" by people in this website by year, and whether "Cathepsin L" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 5 | 5 |
| 2008 | 1 | 7 | 8 |
| 2009 | 3 | 6 | 9 |
| 2010 | 1 | 0 | 1 |
| 2011 | 5 | 3 | 8 |
| 2012 | 3 | 1 | 4 |
| 2013 | 3 | 2 | 5 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 3 | 5 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 2 | 2 |
| 2024 | 1 | 2 | 3 |
| 2025 | 1 | 2 | 3 |
Below are the most recent publications written about "Cathepsin L" by people in Profiles.
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Discovery of benzyl carbamate inhibitors of coronavirus Mpro enzymes from a legacy collection of cysteine protease inhibitors. J Enzyme Inhib Med Chem. 2025 Dec; 40(1):2585619.
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KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage. Nat Genet. 2025 Jun; 57(6):1463-1477.
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Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity. J Med Chem. 2025 Feb 13; 68(3):3626-3652.
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Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease. Eur J Med Chem. 2025 Feb 05; 283:117109.
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Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease. J Med Chem. 2024 Nov 14; 67(21):19038-19056.
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Stromal softness confines pancreatic cancer growth through lysosomal-cathepsin mediated YAP1 degradation. Cell Mol Life Sci. 2024 Oct 26; 81(1):442.
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Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. Biochemistry. 2022 02 15; 61(4):228-238.
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Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases. ACS Chem Neurosci. 2022 01 19; 13(2):245-256.
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Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2022 02 24; 65(4):2956-2970.
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Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J Med Chem. 2021 08 12; 64(15):11267-11287.