George Caughey, MD
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Title(s) | Professor Emeritus, Medicine |
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School | School of Medicine |
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Address | 90 Medical Center Way San Francisco CA 94143
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Phone | 415-221-4810 ext. 6385 |
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vCard | Download vCard |
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Biography University of California, San Francisco | Post-Doc Fellow/Scholar | | Medicine | University of California, San Francisco | Clinical Pulmonary Fellowship | | Medicine | Pennsylvania Hospital | Residency | | Internal Medicine | Stanford University | Doctor of Medicine | | Medicine |
Overview Defining Functions for Epithelial and Inflammatory Cell Proteases in Lung Diseases
The Caughey lab is interested in understanding how protein-cleaving enzymes of mast cells, white blood cells, and cells lining the airway contribute to inflammation, host defense, tissue remodeling and barrier function in the lung. These studies relate to clinical problems in asthma, cystic fibrosis, bronchitis, lung transplantation and bacterial pneumonia. These areas of research are especially related to veterans who have inhaled toxins, who smoke cigarettes, who have received allografts to treat end-stage lung disease, or have lung and bronchial infections. The Caughey lab is perhaps best known for his work with mast cells, which play major roles in allergic diseases, including asthma and fatal reactions to bee stings. He has focused on mast cell proteases, which are enzymes that break down proteins. Over the past decade, the Caughey lab has developed several compelling lines of evidence to suggest that these proteases play deleterious roles in allergic diseases. This work has assisted pharmaceutical development of new classes of anti-inflammatory drugs to treat asthma and other diseases involving mast cells. More recently, he has focused on the positive contributions of mast cells and their proteases to host defense against bacteria and other pathogens, on their role in modulating the inflammatory response to infection, and on defining genetic variation in mast cell protease genes that influence diseases like asthma.
Research Bibliographic
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2020 Jan 23; 180(2):406.
Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. PMID: 31978350.
View in: PubMed Mentions: Fields:
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2019 Oct 03; 179(2):417-431.e19.
Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. PMID: 31585081.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Therapeutic targeting of cathepsin C: from pathophysiology to treatment. Pharmacol Ther. 2018 10; 190:202-236.
Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, L?gowska M, Lesner A, Marchand-Adam S, McKaig SJ, Moss C, Pedersen J, Roberts H, Schreiber A, Seren S, Thakker NS. PMID: 29842917.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimals
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A shocking diagnosis. J Hosp Med. 2017 02; 12(2):104-108.
PMID: 28182807.
View in: PubMed Mentions: Fields: Translation: Humans
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Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 12; 48(12):1564-1569.
PMID: 27749843.
View in: PubMed Mentions: 22 Fields: Translation: Humans
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Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501.
PMID: 27716790.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 10; 100(10):2090-8.
PMID: 27077597.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases. PLoS One. 2015; 10(10):e0141169.
PMID: 26485396.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Mast cell proteases as pharmacological targets. Eur J Pharmacol. 2016 May 05; 778:44-55.
PMID: 25958181.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux. PLoS One. 2015; 10(5):e0125797.
PMID: 25938594.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513.
PMID: 25789765.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014 Aug 13; 15:95.
PMID: 25115556.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):818-823.
PMID: 24955853.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 2013 Sep; 49(3):437-44.
PMID: 23600672.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Malaria-associated L-arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against nontyphoidal Salmonella bacteremia. Infect Immun. 2013 Oct; 81(10):3515-26.
PMID: 23690397.
View in: PubMed Mentions: 33 Fields: Translation: AnimalsCells
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Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12; 288(15):10588-98.
PMID: 23447538.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):417-23.
PMID: 23239157.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. . 2012 Jul; 303(2):L97-106.
PMID: 22582115.
View in: PubMed Mentions:
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The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58.
PMID: 22232213.
View in: PubMed Mentions: 31 Fields: Translation: HumansAnimalsCells
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Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice. PLoS One. 2011; 6(11):e27564.
PMID: 22110673.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84.
PMID: 22075928.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Mast cell proteases as protective and inflammatory mediators. Adv Exp Med Biol. 2011; 716:212-34.
Caughey GH. PMID: 21713659.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol. 2010 Nov 01; 185(9):5360-8.
Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. PMID: 20889553.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol. 2010 May; 125(5):1046-1053.e8.
Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. PMID: 20451039.
View in: PubMed Mentions: 72 Fields: Translation: HumansCells
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Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol. 2010 Mar; 42(3):257-67.
Trivedi NN, Caughey GH. PMID: 19933375.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol. 2009 Nov; 124(5):1099-105.e1-4.
Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. PMID: 19748655.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med. 2009 Aug 01; 180(3):203-10.
Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. PMID: 19423716.
View in: PubMed Mentions: 27 Fields: Translation: Humans
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Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity. J Immunol. 2009 May 01; 182(9):5770-7.
Raymond WW, Su S, Makarova A, Wilson TM, Carter MC, Metcalfe DD, Caughey GH. PMID: 19380825.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem. 2008 May 16; 283(20):13943-51.
Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J. PMID: 18353771.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. J Allergy Clin Immunol. 2008 May; 121(5):1262-8.
Trivedi NN, Raymond WW, Caughey GH. PMID: 18325577.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. J Immunol. 2007 Nov 01; 179(9):6072-9.
Trivedi NN, Tong Q, Raman K, Bhagwandin VJ, Caughey GH. PMID: 17947681.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Mast cell tryptases and chymases in inflammation and host defense. Immunol Rev. 2007 Jun; 217:141-54.
Caughey GH. PMID: 17498057.
View in: PubMed Mentions: 111 Fields: Translation: HumansAnimalsCells
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Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels. Clin Immunol. 2007 Jun; 123(3):268-71.
Akin C, Soto D, Brittain E, Chhabra A, Schwartz LB, Caughey GH, Metcalfe DD. PMID: 17449330.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37.
Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. PMID: 17570216.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol. 2007; 78:23-46.
Planès C, Caughey GH. PMID: 17338914.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimals
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Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17.
Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. PMID: 17158962.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense. Curr Respir Med Rev. 2006 Aug; 2(39):263-277.
Caughey GH. PMID: 18516248.
View in: PubMed Mentions:
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Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6.
Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. PMID: 16895486.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor. . 2006 Dec; 291(6):C1258-70.
Verghese GM, Gutknecht MF, Caughey GH. PMID: 16822939.
View in: PubMed Mentions:
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Tryptase genetics and anaphylaxis. J Allergy Clin Immunol. 2006 Jun; 117(6):1411-4.
Caughey GH. PMID: 16751005.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimals
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Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists. J Biol Chem. 2006 Jan 20; 281(3):1489-94.
Raymond WW, Cruz AC, Caughey GH. PMID: 16303761.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):219-25.
Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH. PMID: 16210667.
View in: PubMed Mentions: 32 Fields: Translation: AnimalsCells
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Transcript signatures of lymphocytic bronchitis in lung allograft biopsy specimens. J Heart Lung Transplant. 2005 Aug; 24(8):1055-66.
Xu X, Golden JA, Dolganov G, Jones KD, Donnelly S, Weaver T, Caughey GH. PMID: 16102441.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Mastin is a gelatinolytic mast cell peptidase resembling a mini-proteasome. Arch Biochem Biophys. 2005 Mar 15; 435(2):311-22.
Raymond WW, Sommerhoff CP, Caughey GH. PMID: 15708374.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol. 2005 Jan; 205(1):102-11.
Somasundaram P, Ren G, Nagar H, Kraemer D, Mendoza L, Michael LH, Caughey GH, Entman ML, Frangogiannis NG. PMID: 15586361.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. . 2004 Nov; 287(5):L928-35.
Tong Z, Illek B, Bhagwandin VJ, Verghese GM, Caughey GH. PMID: 15246975.
View in: PubMed Mentions:
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Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling. . 2004 Aug; 287(2):L307-17.
Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH. PMID: 15075248.
View in: PubMed Mentions:
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Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest. 2004 Feb; 113(4):628-34.
Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters PJ. PMID: 14966572.
View in: PubMed Mentions: 59 Fields: Translation: AnimalsCells
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Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003 Oct-Nov; 384(10-11):1527-31.
Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. PMID: 14669996.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):519-29.
Verghese GM, Tong ZY, Bhagwandin V, Caughey GH. PMID: 12959947.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. J Biol Chem. 2003 Sep 05; 278(36):34517-24.
Raymond WW, Ruggles SW, Craik CS, Caughey GH. PMID: 12815038.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Structure of human pro-chymase: a model for the activating transition of granule-associated proteases. Biochemistry. 2003 Mar 11; 42(9):2616-24.
Reiling KK, Krucinski J, Miercke LJ, Raymond WW, Caughey GH, Stroud RM. PMID: 12614156.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Building a better heparin. Am J Respir Cell Mol Biol. 2003 Feb; 28(2):129-32.
Caughey GH. PMID: 12540478.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
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Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31; 278(5):3363-71.
Bhagwandin VJ, Hau LW, Mallen-St Clair J, Wolters PJ, Caughey GH. PMID: 12441343.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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New developments in the genetics and activation of mast cell proteases. Mol Immunol. 2002 Sep; 38(16-18):1353-7.
Caughey GH. PMID: 12217407.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase. Biochim Biophys Acta. 2002 Apr 29; 1596(2):346-56.
Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH. PMID: 12007614.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions. . 2002 Feb; 282(2):L197-206.
Brown JK, Jones CA, Rooney LA, Caughey GH, Hall IP. PMID: 11792624.
View in: PubMed Mentions:
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Year | Publications |
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2002 | 4 | 2003 | 5 | 2004 | 3 | 2005 | 5 | 2006 | 5 | 2007 | 5 | 2008 | 2 | 2009 | 4 | 2010 | 2 | 2011 | 3 | 2012 | 3 | 2013 | 3 | 2014 | 2 | 2015 | 4 | 2016 | 3 | 2017 | 1 | 2018 | 1 | 2019 | 1 | 2020 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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