"Homeobox Protein Nkx-2.5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A homeobox-containing transcription factor that functions in heart development. Mutations in the NKX2-5 gene are associated with ATRIAL SEPTAL DEFECTS and TETRALOGY OF FALLOT.
| Descriptor ID |
D000072576
|
| MeSH Number(s) |
D12.776.260.400.234 D12.776.930.324
|
| Concept/Terms |
Homeobox Protein Nkx-2.5- Homeobox Protein Nkx-2.5
- Homeobox Protein Nkx 2.5
- Nkx-2.5, Homeobox Protein
- NK2 Homeobox 5 Protein
- Homeobox Transcription Factor Csx-Nkx2-5
- Homeobox Transcription Factor Csx Nkx2 5
- Homeobox Protein Csx-Nkx2.5
- Csx-Nkx2.5, Homeobox Protein
- Homeobox Protein Csx Nkx2.5
- Cardiac-Specific Homeobox Protein
- Cardiac Specific Homeobox Protein
- Homeobox Protein, Cardiac-Specific
- Transcription Factor Nkx-2.5
- Nkx-2.5, Transcription Factor
- Transcription Factor Nkx 2.5
|
Below are MeSH descriptors whose meaning is more general than "Homeobox Protein Nkx-2.5".
Below are MeSH descriptors whose meaning is more specific than "Homeobox Protein Nkx-2.5".
This graph shows the total number of publications written about "Homeobox Protein Nkx-2.5" by people in this website by year, and whether "Homeobox Protein Nkx-2.5" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 6 | 6 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 7 | 7 |
| 2010 | 0 | 4 | 4 |
| 2011 | 0 | 6 | 6 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 5 | 5 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 4 | 4 |
| 2017 | 3 | 2 | 5 |
| 2019 | 3 | 1 | 4 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Homeobox Protein Nkx-2.5" by people in Profiles.
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The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5. Stem Cell Reports. 2023 11 14; 18(11):2138-2153.
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Activation of Nkx2.5 transcriptional program is required for adult myocardial repair. Nat Commun. 2022 05 27; 13(1):2970.
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Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation. Cell Rep. 2021 12 07; 37(10):110095.
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Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol. 2020 09 04; 432(19):5499-5508.
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The role of cardiac transcription factor NKX2-5 in regulating the human cardiac miRNAome. Sci Rep. 2019 11 04; 9(1):15928.
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Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. Nat Genet. 2019 10; 51(10):1506-1517.
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Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nat Commun. 2019 09 11; 10(1):4113.
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Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes. Dev Cell. 2019 09 23; 50(6):729-743.e5.
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Oligogenic inheritance of a human heart disease involving a genetic modifier. Science. 2019 05 31; 364(6443):865-870.
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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nat Commun. 2018 04 10; 9(1):1373.