Qili Liu, PhD

Title(s)Assistant Professor, Anatomy
SchoolSchool of Medicine
Address1550 Fourth Street, #348D
San Francisco CA 94158
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    Collapse Biography 
    Collapse Awards and Honors
    2021Pew Biomedical Scholar Award
    2020Klingenstein-Simons Fellowship Award in Neuroscience
    2020NIGMS MIRA Award
    2019UCSF Weill Pilot Award for Junior Investigators
    2019UCSF PBBR New Frontiers Research Award
    2019Mallinckrodt Young Investigator Award
    2019UCSF NORC Pilot and Feasibility Award

    Collapse Overview 
    Collapse Overview
    Animals can exhibit hunger for not only calories but also specific nutrients, which energize behaviors to search for and ingest particular types of food in response to internal nutritional deficiency. My lab aims to understand the neurobiological basis of nutrient-specific appetite, and investigate how hunger for distinct nutrients are systematically coordinated to ensure that a balanced diet is consumed. To this end, we will harness the power of the Drosophila model system and employ a multidisciplinary approach, including large-scale genetic and behavioral analyses, immunohistochemistry, functional imaging, and patch-clamp electrophysiology. These studies will shed light on the fundamental principles for the organization and modulation of motivated behaviors. Given the global obesity epidemic, illuminating the regulation of food choice guided by nutrient specific appetite may facilitate the development of novel treatments for obesity.
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism and Modulation of the homeostatic setpoint for protein feeding
    NIH R01NS123890Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Genetic dissection of motivational drive to eat
    NIH R35GM138060Sep 1, 2020 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep. Cell. 2018 11 15; 175(5):1213-1227.e18. Tabuchi M, Monaco JD, Duan G, Bell B, Liu S, Liu Q, Zhang K, Wu MN. PMID: 30318147; PMCID: PMC6239908.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    2. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018 Apr 10; 23(2):652-665. Xie T, Ho MCW, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, Wu MN. PMID: 29642019; PMCID: PMC5962273.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    3. Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger. Science. 2017 05 05; 356(6337):534-539. Liu Q, Tabuchi M, Liu S, Kodama L, Horiuchi W, Daniels J, Chiu L, Baldoni D, Wu MN. PMID: 28473588; PMCID: PMC5513152.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    4. Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit. Cell. 2016 Jun 02; 165(6):1347-1360. Liu S, Liu Q, Tabuchi M, Wu MN. PMID: 27212237; PMCID: PMC4892967.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    5. Sleep interacts with aβ to modulate intrinsic neuronal excitability. Curr Biol. 2015 Mar 16; 25(6):702-712. Tabuchi M, Lone SR, Liu S, Liu Q, Zhang J, Spira AP, Wu MN. PMID: 25754641; PMCID: PMC4366315.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    6. WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 2014 Apr 02; 82(1):151-66. Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN. PMID: 24631345; PMCID: PMC3982794.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    7. Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. Curr Biol. 2012 Nov 20; 22(22):2114-23. Liu Q, Liu S, Kodama L, Driscoll MR, Wu MN. PMID: 23022067; PMCID: PMC3505250.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    8. The ARGONAUTE10 gene modulates shoot apical meristem maintenance and establishment of leaf polarity by repressing miR165/166 in Arabidopsis. Plant J. 2009 Apr; 58(1):27-40. Liu Q, Yao X, Pi L, Wang H, Cui X, Huang H. PMID: 19054365.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    9. Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis. Plant Cell Physiol. 2006 Jul; 47(7):853-63. Xu L, Yang L, Pi L, Liu Q, Ling Q, Wang H, Poethig RS, Huang H. PMID: 16699177.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
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