Tom Kornberg, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Tumor cytonemes, a new target for tumor suppression
    NIH R21CA205580Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Gene regulation and function in early embryos
    NIH R01GM109410May 1, 2014 - Jan 31, 2018
    Role: Principal Investigator
    Hedgehog signaling and signal transduction
    NIH R01GM105987Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    NIH R01HL084184Sep 28, 2007 - Jun 30, 2012
    Role: Principal Investigator
    NIH R01GM077407May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    NIH R01GM059256Feb 1, 2000 - Jan 31, 2006
    Role: Principal Investigator
    NIH S10RR007145Sep 1, 1992 - Aug 31, 1993
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    NIH R01GM036506Apr 1, 1986 - Jun 30, 1990
    Role: Principal Investigator
    NIH P01GM031286Feb 1, 1983 - Jan 31, 1993
    Role: Co-Investigator
    Molecular Mechanisms in Development
    NIH R01GM030637Mar 1, 1982 - Dec 31, 2019
    Role: Principal Investigator
    NIH R01GM059466Jun 1, 1981 - Mar 31, 2004
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH/NIGMS T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Principal Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):334-346.e4. PMID: 29307513.
      View in: PubMed
    2. Kornberg TB. Scripting a place in time. Dev Biol. 2017 Sep 13. PMID: 28916168.
      View in: PubMed
    3. Chen W, Huang H, Hatori R, Kornberg TB. Essential basal cytonemes take up Hedgehog in the Drosophila wing imaginal disc. Development. 2017 09 01; 144(17):3134-3144. PMID: 28743798.
      View in: PubMed
    4. Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477). PMID: 28465421.
      View in: PubMed
    5. Kornberg TB. Macrophages Help Cells Connect to Pattern Zebrafish Stripes. Dev Cell. 2017 03 27; 40(6):520-521. PMID: 28350985.
      View in: PubMed
    6. Ali-Murthy Z, Kornberg TB. Correction: Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm. Elife. 2017 03 15; 6. PMID: 28296637.
      View in: PubMed
    7. Kornberg TB. Distributing signaling proteins in space and time: the province of cytonemes. Curr Opin Genet Dev. 2017 Aug; 45:22-27. PMID: 28242479.
      View in: PubMed
    8. Huang H, Kornberg TB. Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes. Elife. 2016 09 03; 5. PMID: 27591355.
      View in: PubMed
    9. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. PMID: 27273096.
      View in: PubMed
    10. Ali-Murthy Z, Kornberg TB. Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm. Elife. 2016 Feb 17; 5. PMID: 26883601; PMCID: PMC4786422.
    11. Kornberg TB. A Path to Pattern. Curr Top Dev Biol. 2016; 116:551-67. PMID: 26970641.
      View in: PubMed
    12. Rao PR, Lin L, Huang H, Guha A, Roy S, Kornberg TB. Developmental compartments in the larval trachea of Drosophila. Elife. 2015 Oct 22; 4. PMID: 26491942; PMCID: PMC4718809.
    13. Kornberg TB, Gilboa L. Developmental biology: Nanotubes in the niche. Nature. 2015 Jul 16; 523(7560):292-3. PMID: 26131936.
      View in: PubMed
    14. Huang H, Kornberg TB. Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium. Elife. 2015 May 07; 4:e06114. PMID: 25951303; PMCID: PMC4423120.
    15. Roy S, Kornberg TB. Paracrine signaling mediated at cell-cell contacts. Bioessays. 2015 Jan; 37(1):25-33. PMID: 25476066; PMCID: PMC4407995.
    16. Kornberg TB. Cytonemes and the dispersion of morphogens. Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec; 3(6):445-63. PMID: 25186102.
      View in: PubMed
    17. Kornberg TB. The contrasting roles of primary cilia and cytonemes in Hh signaling. Dev Biol. 2014 Oct 01; 394(1):1-5. PMID: 25072627; PMCID: PMC4163518.
    18. Guerrero I, Kornberg TB. Hedgehog and its circuitous journey from producing to target cells. Semin Cell Dev Biol. 2014 Sep; 33:52-62. PMID: 24994598.
      View in: PubMed
    19. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. PMID: 24832154; PMCID: PMC4077998.
    20. Kornberg TB, Roy S. Communicating by touch--neurons are not alone. Trends Cell Biol. 2014 Jun; 24(6):370-6. PMID: 24560610.
      View in: PubMed
    21. Kornberg TB, Roy S. Cytonemes as specialized signaling filopodia. Development. 2014 Feb; 141(4):729-36. PMID: 24496611.
      View in: PubMed
    22. Roy S, Huang H, Liu S, Kornberg TB. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science. 2014 Feb 21; 343(6173):1244624. PMID: 24385607; PMCID: PMC4336149.
    23. Ibrahim DM, Biehs B, Kornberg TB, Klebes A. Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes. G3 (Bethesda). 2013 Aug 07; 3(8):1353-62. PMID: 23749451; PMCID: PMC3737175.
    24. Ali-Murthy Z, Lott SE, Eisen MB, Kornberg TB. An essential role for zygotic expression in the pre-cellular Drosophila embryo. PLoS Genet. 2013 Apr; 9(4):e1003428. PMID: 23593026.
      View in: PubMed
    25. Kornberg TB. The imperatives of context and contour for morphogen dispersion. Biophys J. 2012 Dec 05; 103(11):2252-6. PMID: 23283223; PMCID: PMC3514522.
    26. Casso DJ, Liu S, Biehs B, Kornberg TB. Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. PLoS One. 2012; 7(3):e33827. PMID: 22439002; PMCID: PMC3306293.
    27. Roy S, Kornberg TB. Direct delivery mechanisms of morphogen dispersion. Sci Signal. 2011 Nov 22; 4(200):pt8. PMID: 22114143.
      View in: PubMed
    28. Kornberg TB. Barcoding Hedgehog for intracellular transport. Sci Signal. 2011 Nov 22; 4(200):pe44. PMID: 22114141; PMCID: PMC4337800.
    29. Roy S, Hsiung F, Kornberg TB. Specificity of Drosophila cytonemes for distinct signaling pathways. Science. 2011 Apr 15; 332(6027):354-8. PMID: 21493861; PMCID: PMC3109072.
    30. Casso DJ, Biehs B, Kornberg TB. A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics. 2011 Feb; 187(2):485-99. PMID: 21098717; PMCID: PMC3030491.
    31. Biehs B, Kechris K, Liu S, Kornberg TB. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010 Nov; 137(22):3887-98. PMID: 20978080; PMCID: PMC3049281.
    32. Kechris KJ, Biehs B, Kornberg TB. Generalizing moving averages for tiling arrays using combined p-value statistics. Stat Appl Genet Mol Biol. 2010; 9:Article29. PMID: 20812907; PMCID: PMC2942027.
    33. Baig J, Chanut F, Kornberg TB, Klebes A. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics. 2010 Mar; 184(3):731-44. PMID: 20008573; PMCID: PMC2845341.
    34. Guha A, Lin L, Kornberg TB. Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol. 2009 Nov 15; 335(2):317-26. PMID: 19751719; PMCID: PMC2784283.
    35. Kawamura S, Hervold K, Ramirez-Weber FA, Kornberg TB. Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem. 2008 Nov 07; 283(45):30964-9. PMID: 18768465; PMCID: PMC2576558.
    36. Guha A, Lin L, Kornberg TB. Organ renewal and cell divisions by differentiated cells in Drosophila. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10832-6. PMID: 18664581.
      View in: PubMed
    37. Casso DJ, Liu S, Iwaki DD, Ogden SK, Kornberg TB. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008 Mar; 178(3):1399-413. PMID: 18245841; PMCID: PMC2278107.
    38. Klebes A, Kornberg TB. Linear RNA amplification for the production of microarray hybridization probes. Methods Mol Biol. 2008; 420:303-17. PMID: 18641956.
      View in: PubMed
    39. Kornberg TB, Guha A. Understanding morphogen gradients: a problem of dispersion and containment. Curr Opin Genet Dev. 2007 Aug; 17(4):264-71. PMID: 17643982; PMCID: PMC1993832.
    40. Lu X, Liu S, Kornberg TB. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 2006 Sep 15; 20(18):2539-51. PMID: 16980583; PMCID: PMC1578677.
    41. Ogden SK, Casso DJ, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem. 2006 Mar 17; 281(11):7237-43. PMID: 16423832; PMCID: PMC3677211.
    42. Guha A, Kornberg TB. Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol. 2005 Nov 01; 287(1):192-200. PMID: 16198330.
      View in: PubMed
    43. Hsiung F, Ramirez-Weber FA, Iwaki DD, Kornberg TB. Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature. 2005 Sep 22; 437(7058):560-3. PMID: 16177792.
      View in: PubMed
    44. Klebes A, Sustar A, Kechris K, Li H, Schubiger G, Kornberg TB. Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Development. 2005 Aug; 132(16):3753-65. PMID: 16077094.
      View in: PubMed
    45. Casso DJ, Tanda S, Biehs B, Martoglio B, Kornberg TB. Drosophila signal peptide peptidase is an essential protease for larval development. Genetics. 2005 May; 170(1):139-48. PMID: 15716490; PMCID: PMC1449732.
    46. Sato M, Kornberg TB. FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system. Dev Cell. 2002 Aug; 3(2):195-207. PMID: 12194851.
      View in: PubMed
    47. Klebes A, Biehs B, Cifuentes F, Kornberg TB. Expression profiling of Drosophila imaginal discs. Genome Biol. 2002 Jul 24; 3(8):RESEARCH0038. PMID: 12186645; PMCID: PMC126232.
    48. Kornberg T. Another arrow in the Drosophila quiver. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9607-8. PMID: 12122216; PMCID: PMC124942.