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Yuh Nung Jan, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Phone415-476-8747
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    Other Positions
    Title(s)Howard Hughes Investigator


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    Dendrite morphogenesis, function and regeneration
    NIH R35NS097227Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Molecular mechanisms of dendrite development in mammalian CNS
    NIH R01MH084234Jan 1, 2004 - Jan 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of dendrite development in mammalia
    NIH R01NS047200Jan 1, 2004 - Dec 31, 2007
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R37NS040929Jan 18, 2001 - Dec 31, 2016
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R01NS040929Jan 18, 2001 - Nov 30, 2009
    Role: Principal Investigator
    LONGTERM CHANGES IN THE MAMMALIAN BRAIN
    NIH/NIMH P50MH048200Sep 1, 1991 - Aug 31, 2002
    Role: Co-Investigator
    SLOW POTENTIALS IN AUTONOMIC GANGLIA
    NIH R01NS015757Dec 1, 1979 - Jun 30, 1988
    Role: Principal Investigator

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    Collapse In The News
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11):5126-5134. PMID: 30804200.
      View in: PubMed
    2. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 Feb 15. PMID: 30819546.
      View in: PubMed
    3. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. PMID: 30622179.
      View in: PubMed
    4. Kwon MJ, Han MH, Bagley JA, Hyeon DY, Ko BS, Lee YM, Cha IJ, Kim SY, Kim DY, Kim HM, Hwang D, Lee SB, Jan YN. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10748-E10757. PMID: 30348793.
      View in: PubMed
    5. Jan LY, Jan YN. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 Jun 04; 150(6):773-775. PMID: 29769227.
      View in: PubMed
    6. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414. PMID: 29563183.
      View in: PubMed
    7. Jan YN, Jan LY. Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470. PMID: 29469134.
      View in: PubMed
    8. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 Mar 07; 97(5):1063-1077.e4. PMID: 29478917.
      View in: PubMed
    9. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674. PMID: 29382763.
      View in: PubMed
    10. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. PMID: 29236684.
      View in: PubMed
    11. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11161-E11169. PMID: 29229864.
      View in: PubMed
    12. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. PMID: 29212016.
      View in: PubMed
    13. Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN. Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Cell Rep. 2017 Oct 24; 21(4):859-866. PMID: 29069593.
      View in: PubMed
    14. Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW. Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity. Cell Rep. 2017 Aug 22; 20(8):1855-1866. PMID: 28834749.
      View in: PubMed
    15. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature. 2017 07 06; 547(7661):118-122. PMID: 28658211.
      View in: PubMed
    16. Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN. Age-dependent diastolic heart failure in an in vivo Drosophila model. Elife. 2017 03 22; 6. PMID: 28328397.
      View in: PubMed
    17. Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18; 93(2):379-393. PMID: 28065648.
      View in: PubMed
    18. Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN. A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles. J Neurosci. 2016 11 02; 36(44):11275-11282. PMID: 27807168.
      View in: PubMed
    19. Thayer DA, Yang SB, Jan YN, Jan LY. N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels. J Physiol. 2016 11 15; 594(22):6701-6713. PMID: 27377235.
      View in: PubMed
    20. Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN. In vivo dendrite regeneration after injury is different from dendrite development. Genes Dev. 2016 08 01; 30(15):1776-89. PMID: 27542831; PMCID: PMC5002981 [Available on 02/01/17].
    21. Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7243-8. PMID: 27298354; PMCID: PMC4932980 [Available on 12/28/16].
    22. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. PMID: 27112495; PMCID: PMC4860041 [Available on 05/04/17].
    23. Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN. Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron. 2016 Feb 17; 89(4):741-55. PMID: 26853303.
      View in: PubMed
    24. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. PMID: 26549191; PMCID: PMC4815332 [Available on 02/01/17].
    25. Lin T, Pan PY, Lai YT, Chiang KW, Hsieh HL, Wu YP, Ke JM, Lee MC, Liao SS, Shih HT, Tang CY, Yang SB, Cheng HC, Wu JT, Jan YN, Lee HH. Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons. PLoS Genet. 2015 Nov; 11(11):e1005642. PMID: 26540204; PMCID: PMC4634852.
    26. Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN. Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel. Cell. 2015 Sep 10; 162(6):1391-403. PMID: 26359990; PMCID: PMC4568062.
    27. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46. PMID: 26258683; PMCID: PMC4639927.
    28. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5. PMID: 26098020; PMCID: PMC4521985.
    29. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. PMID: 25961792.
      View in: PubMed
    30. Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN. The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. Elife. 2015 Mar 12; 4. PMID: 25764303; PMCID: PMC4391025.
    31. Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY. Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3547-52. PMID: 25733897; PMCID: PMC4371966.
    32. To TL, Piggott BJ, Makhijani K, Yu D, Jan YN, Shu X. Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3338-43. PMID: 25733847; PMCID: PMC4371907.
    33. Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 03; 84(5):968-82. PMID: 25456499; PMCID: PMC4407996.
    34. Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN. Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila. Cell Rep. 2014 Nov 20; 9(4):1446-58. PMID: 25456135.
      View in: PubMed
    35. Zhang W, Yan Z, Li B, Jan LY, Jan YN. Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. Elife. 2014 Oct 30; 3. PMID: 25358089; PMCID: PMC4244571.
    36. Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN. Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 2014 Sep 01; 28(17):1940-56. PMID: 25184680; PMCID: PMC4197945.
    37. Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife. 2014 Jun 30; 3. PMID: 24980701; PMCID: PMC4112547.
    38. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. PMID: 24832154; PMCID: PMC4077998.
    39. Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW. Krüppel mediates the selective rebalancing of ion channel expression. Neuron. 2014 May 07; 82(3):537-44. PMID: 24811378; PMCID: PMC4104505.
    40. Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN. Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7331-6. PMID: 24799714; PMCID: PMC4034197.
    41. Han C, Song Y, Xiao H, Wang D, Franc NC, Jan LY, Jan YN. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014 Feb 05; 81(3):544-560. PMID: 24412417; PMCID: PMC3995171.
    42. Kim WJ, Jan LY, Jan YN. A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating. Neuron. 2013 Dec 04; 80(5):1190-205. PMID: 24314729; PMCID: PMC3867312.
    43. Yuan Q, Song Y, Yang CH, Jan LY, Jan YN. Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila. Nat Neurosci. 2014 Jan; 17(1):81-8. PMID: 24241395; PMCID: PMC3995170.
    44. Wong XM, Younger S, Peters CJ, Jan YN, Jan LY. Subdued, a TMEM16 family Ca²?-activated Cl?channel in Drosophila melanogaster with an unexpected role in host defense. Elife. 2013 Nov 05; 2:e00862. PMID: 24192034; PMCID: PMC3814000.
    45. Zhang W, Yan Z, Jan LY, Jan YN. Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13612-7. PMID: 23898199; PMCID: PMC3746866.
    46. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. PMID: 23872594; PMCID: PMC4034143.
    47. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. PMID: 23576756; PMCID: PMC3631655.
    48. Thayer DA, Jan YN, Jan LY. Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1482-7. PMID: 23297202; PMCID: PMC3557034.
    49. Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN. Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431):221-5. PMID: 23222543; PMCID: PMC3917554.
    50. Ori-McKenney KM, Jan LY, Jan YN. Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron. 2012 Dec 06; 76(5):921-30. PMID: 23217741; PMCID: PMC3523279.
    51. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. PMID: 23021219; PMCID: PMC3582364.
    52. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    53. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. PMID: 22884327; PMCID: PMC3467009.
    54. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96. PMID: 22855790; PMCID: PMC3426758.
    55. Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 2012 Jul 15; 26(14):1612-25. PMID: 22759636; PMCID: PMC3404388.
    56. Kim WJ, Jan LY, Jan YN. Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals. Nat Neurosci. 2012 Jun; 15(6):876-83. PMID: 22561453; PMCID: PMC3417086.
    57. Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY. Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron. 2012 Apr 12; 74(1):179-92. PMID: 22500639; PMCID: PMC3329964.
    58. Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80. PMID: 22456708; PMCID: PMC3777276.
    59. Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012 Mar 22; 73(6):1127-42. PMID: 22445341; PMCID: PMC3333840.
    60. Jan LY, Jan YN. Voltage-gated potassium channels and the diversity of electrical signalling. J Physiol. 2012 Jun 01; 590(11):2591-9. PMID: 22431339; PMCID: PMC3424718.
    61. Yang SB, Mclemore KD, Tasic B, Luo L, Jan YN, Jan LY. Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers. J Physiol. 2012 Jun 01; 590(11):2645-58. PMID: 22411008; PMCID: PMC3424722.
    62. Jan YN. Yoshiki Hotta's influence. J Neurogenet. 2012 Mar; 26(1):3-4. PMID: 22263807.
      View in: PubMed
    63. Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan YN. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron. 2012 Jan 12; 73(1):64-78. PMID: 22243747; PMCID: PMC3269260.
    64. Fieni F, Lee SB, Jan YN, Kirichok Y. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 2012; 3:1317. PMID: 23271651; PMCID: PMC3818247.
    65. Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN. Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20615-20. PMID: 22143802; PMCID: PMC3251047.
    66. Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl). 2012 May; 90(5):575-85. PMID: 22105852.
      View in: PubMed
    67. Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron. 2011 Nov 17; 72(4):630-42. PMID: 22099464; PMCID: PMC3433402.
    68. Lee SB, Bagley JA, Lee HY, Jan LY, Jan YN. Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16795-800. PMID: 21930920; PMCID: PMC3189048.
    69. Yuan Q, Xiang Y, Yan Z, Han C, Jan LY, Jan YN. Light-induced structural and functional plasticity in Drosophila larval visual system. Science. 2011 Sep 09; 333(6048):1458-62. PMID: 21903815; PMCID: PMC4114502.
    70. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96. PMID: 21558368; PMCID: PMC3091490.
    71. Han C, Jan LY, Jan YN. Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9673-8. PMID: 21606367; PMCID: PMC3111288.
    72. Ye B, Kim JH, Yang L, McLachlan I, Younger S, Jan LY, Jan YN. Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1. J Neurosci. 2011 Mar 02; 31(9):3309-19. PMID: 21368042; PMCID: PMC3086283.
    73. Rumpf S, Lee SB, Jan LY, Jan YN. Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development. 2011 Mar; 138(6):1153-60. PMID: 21343367; PMCID: PMC3042870.
    74. Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010 Dec 16; 468(7326):921-6. PMID: 21068723; PMCID: PMC3026603.
    75. Cheng LE, Song W, Looger LL, Jan LY, Jan YN. The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron. 2010 Aug 12; 67(3):373-80. PMID: 20696376.
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    76. Young DM, Schenk AK, Yang SB, Jan YN, Jan LY. Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11074-9. PMID: 20534473; PMCID: PMC2890736.
    77. Jan YN, Jan LY. Branching out: mechanisms of dendritic arborization. Nat Rev Neurosci. 2010 May; 11(5):316-28. PMID: 20404840; PMCID: PMC3079328.
    78. Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21413-8. PMID: 19965375; PMCID: PMC2781737.
    79. Kim MD, Wen Y, Jan YN. Patterning and organization of motor neuron dendrites in the Drosophila larva. Dev Biol. 2009 Dec 15; 336(2):213-21. PMID: 19818341; PMCID: PMC2785125.
    80. Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN. The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron. 2009 Sep 24; 63(6):788-802. PMID: 19778508; PMCID: PMC2772869.
    81. Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009 Jul 30; 63(2):189-202. PMID: 19640478; PMCID: PMC2736606.
    82. Lee HH, Jan LY, Jan YN. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6363-8. PMID: 19329489.
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    83. Yang CH, Rumpf S, Xiang Y, Gordon MD, Song W, Jan LY, Jan YN. Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron. 2009 Feb 26; 61(4):519-26. PMID: 19249273; PMCID: PMC2748846.
    84. Chung HJ, Ge WP, Qian X, Wiser O, Jan YN, Jan LY. G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):635-40. PMID: 19118199.
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    85. Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY. Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):629-34. PMID: 19118198.
      View in: PubMed
    86. Ge WP, Zhou W, Luo Q, Jan LY, Jan YN. Dividing glial cells maintain differentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):328-33. PMID: 19104058.
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