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Yuh Nung Jan, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Address1550 Fourth Street, #384E
San Francisco CA 94158
Phone415-502-0725
PronounsHe/Him/His
ORCID ORCID Icon0000-0003-1367-6299 Additional info
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    Other Positions
    Title(s)Jack and De Loris Lange Endowed Chair of Molecular Physiology

    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse education and training
    National Taiwan University, TaiwanB.Sc.1967Physics
    Communication and Electronics Officer, Second Lieutenant, Signal Corp, Air Force (Taiwan)MILITARY SERVICE (COMPULSORY)1968
    California Institute of Technology, CAM.Sc.1970Physics
    California Institute of Technology, CAPh.D.1974Biophysics and Physics
    California Institute of TechnologyPostdoctoral Research Fellow1977Neuroscience (Dr. Seymour Benzer)
    Department of Neurobiology, Harvard Medical SchoolPostdoctoral Research Fellow1979Neuroscience (Dr. Steve W. Kuffler)
    Collapse awards and honors
    *Together with Lily Jan2022  - 2022*Stephen W. Kuffler Lectures, UCSD
    *Together with Lily Jan2020  - 2020*20th Perl-UNC Neuroscience Prize
    *Together with Lily Jan2017  - 2017*Vilcek Prize in Biomedical Science
    *Together with Lily Jan2016  - 2016*Jan Lab Symposium II
    *Together with Lily Jan2015  - 2015*F.M. Kirby Visiting Professor, Kirby Center, Children's Hospital Harvard Medical School
    2012  - 2012Distinguished Alumni Award, Department of Physics, National Taiwan University
    *Together with Lily Jan2012  - 2012*Gruber Neuroscience Prize
    *Together with Lily Jan2011  - 2011*Wiley Prize in Biomedical Sciences
    2011  - 2011Albert Einstein in Professorship, Chinese Academy of Sciences
    2011  - 2011Seymour Benzer Lecture, Cold Spring Harbor Lab
    *Together with Lily Jan2010  - 2010*Edward. M. Scolnick Prize in Neuroscience, Massachusetts Instituteof Technology
    2010  - 2010Javits Neuroscience Investigator Award, NINDS, NIH
    *Together with Lily Jan2010  - 2010*Albert and Ellen Grass Lecture, Society for Neuroscience
    2010  - 2010NARSAD Distinguished Investigator Award
    *Together with Lily Jan2009  - 2009*Ralph Gerard Prize, Society for Neuroscience
    2007  - 2007Elected member, American Academy of Arts and Sciences
    *Together with Lily Jan2007  - 2007*Outstanding Mentorship Award, The Postdoctoral Scholar's Association of UCSF
    2006  - 2006Distinguished Alumni Award, California Institute of Technology
    *Together with Lily Jan2006  - 2006*SCBA Presidential Award
    *Together with Lily Jan2006  - 2006*Jan Lab Symposium
    *Together with Lily Jan2004  - 2004*K.S. Cole Award, Biophysical Society
    *Together with Lily Jan1999  - 1999*The Stephen Kuffler Lecture, Harvard Medical School
    1998  - 1998Elected member, Academia Sinica (Taiwan)
    *Together with Lily Jan1998  - 1998*Harvey Lecture
    1996  - 1996Elected member, National Academy of Sciences, U.S.A.
    *Together with Lily Jan1995  - 1995*38th Faculty Lecturer, University of California, San Francisco
    *Together with Lily Jan1988  - 1988*W. Alden Spencer Award and Lectureship, Columbia University
    1978  - 1978McKnight Scholar Award
    1976  - 1976Muscular Dystrophy Association Postdoctoral Fellowship
    1974  - 1974Scottish Rite Schizophrenia Research Program Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Dendrite development, function, degeneration and regeneration
    NIH R35NS137312Dec 15, 2024 - Nov 30, 2032
    Role: Principal Investigator
    Dendrite morphogenesis, function and regeneration
    NIH R35NS097227Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Molecular mechanisms of dendrite development in mammalian CNS
    NIH R01MH084234Jan 1, 2004 - Jan 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of dendrite development in mammalia
    NIH R01NS047200Jan 1, 2004 - Dec 31, 2007
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R37NS040929Jan 18, 2001 - Dec 31, 2016
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R01NS040929Jan 18, 2001 - Nov 30, 2009
    Role: Principal Investigator
    LONGTERM CHANGES IN THE MAMMALIAN BRAIN
    NIH P50MH048200Sep 1, 1991 - Aug 31, 2002
    Role: Co-Investigator
    SLOW POTENTIALS IN AUTONOMIC GANGLIA
    NIH R01NS015757Dec 1, 1979 - Jun 30, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CLN3 mediates chloride efflux from lysosomes. Neuron. 2026 Mar 04; 114(5):868-883.e7. Wang Y, Li K, Chen W, Chen C, Yong AJH, Zhang X, Tynan-La Fontaine M, Jan YN, Jan LY. PMID: 41558486; PMCID: PMC12994750.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity. bioRxiv. 2025 Nov 11. Zhang X, Chen W, Wang Y, Tu X, Zhang X, Davis RL, Jan LY, Jan YN. PMID: 40950227; PMCID: PMC12425008.
      View in: PubMed   Mentions:
    3. A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane. Proc Natl Acad Sci U S A. 2025 Nov 04; 122(44):e2516822122. Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY. PMID: 41166415; PMCID: PMC12595458.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila. Neuron. 2025 Oct 15; 113(20):3352-3362.e5. Guo Y, Li T, Tuomivaara ST, Teo CF, Feng S, Chalkley RJ, Zhu R, Cheng T, Li KH, Chen W, Simon A, Jin P, Younger S, Yong AJH, Li K, Li K, Burlingame AL, Jan LY, Jan YN. PMID: 41045928; PMCID: PMC12774293.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane. bioRxiv. 2025 Jun 27. Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY. PMID: 40667283; PMCID: PMC12262486.
      View in: PubMed   Mentions:
    6. Experimental tools and emerging principles of organellar mechanotransduction. Trends Cell Biol. 2025 Nov; 35(11):944-954. Li K, Jan YN. PMID: 39828483.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families. Nat Struct Mol Biol. 2025 Feb; 32(2):222-236. Jan LY, Jan YN. PMID: 39715905.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling. Commun Biol. 2024 08 29; 7(1):1060. Tuomivaara ST, Teo CF, Jan YN, Wiita AP, Jan LY. PMID: 39210032; PMCID: PMC11362511.
      View in: PubMed   Mentions: 9  Translation:HumansAnimalsCells
    9. TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons. Proc Natl Acad Sci U S A. 2024 Jul 02; 121(27):e2311831121. Zubia MV, Yong AJH, Holtz KM, Huang EJ, Jan YN, Jan LY. PMID: 38941274; PMCID: PMC11228522.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Nonlinear compliance of NompC gating spring and its implication in mechanotransduction. bioRxiv. 2024 Jun 24. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y. PMID: 38979198; PMCID: PMC11230213.
      View in: PubMed   Mentions:
    11. Molecular recording of calcium signals via calcium-dependent proximity labeling. Nat Chem Biol. 2024 Jul; 20(7):894-905. Kim JW, Yong AJH, Aisenberg EE, Lobel JH, Wang W, Dawson TM, Dawson VL, Gao R, Jan YN, Bateup HS, Ingolia NT. PMID: 38658655.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    12. A personal perspective of the voltage-gated potassium channel studies. Nat Struct Mol Biol. 2024 Apr; 31(4):580-581. Jan LY, Jan YN. PMID: 38548955.
      View in: PubMed   Mentions:    Fields:    
    13. Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels. Nat Cell Biol. 2024 03; 26(3):393-403. Li K, Guo Y, Wang Y, Zhu R, Chen W, Cheng T, Zhang X, Jia Y, Liu T, Zhang W, Jan LY, Jan YN. PMID: 38388853; PMCID: PMC10940159.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun. 2023 08 12; 14(1):4874. Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY. PMID: 37573365; PMCID: PMC10423226.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    15. A new cell in an old tactile sensory organ. Nat Cell Biol. 2023 04; 25(4):518-519. Zhu R, Jan YN. PMID: 37059881.
      View in: PubMed   Mentions:    Fields:    
    16. SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling. bioRxiv. 2023 Mar 26. Tuomivaara ST, Teo CF, Jan YN, Jan LY, Wiita AP. PMID: 36993417; PMCID: PMC10055316.
      View in: PubMed   Mentions:
    17. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. J Cell Biol. 2023 01 02; 222(1). O'Brien CE, Younger SH, Jan LY, Jan YN. PMID: 36239632; PMCID: PMC9577387.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2204577119. Liu HH, Hsu CH, Jan LY, Jan YN. PMID: 35969739; PMCID: PMC9407391.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2118240119. Lin King YH, Chen C, Lin King JV, Simms J, Glasscock E, Yang SB, Jan YN, Jan LY. PMID: 35613055; PMCID: PMC9295736.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development. Elife. 2022 03 30; 11. Jaszczak JS, DeVault L, Jan LY, Jan YN. PMID: 35353036; PMCID: PMC8967384.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science. 2022 03 04; 375(6584):eabk2432. Li H, Janssens J, De Waegeneer M, Kolluru SS, Davie K, Gardeux V, Saelens W, David FPA, Brbic M, Spanier K, Leskovec J, McLaughlin CN, Xie Q, Jones RC, Brueckner K, Shim J, Tattikota SG, Schnorrer F, Rust K, Nystul TG, Carvalho-Santos Z, Ribeiro C, Pal S, Mahadevaraju S, Przytycka TM, Allen AM, Goodwin SF, Berry CW, Fuller MT, White-Cooper H, Matunis EL, DiNardo S, Galenza A, O'Brien LE, Dow JAT, FCA Consortium§, Jasper H, Oliver B, Perrimon N, Deplancke B, Quake SR, Luo L, Aerts S, Agarwal D, Ahmed-Braimah Y, Arbeitman M, Ariss MM, Augsburger J, Ayush K, Baker CC, Banisch T, Birker K, Bodmer R, Bolival B, Brantley SE, Brill JA, Brown NC, Buehner NA, Cai XT, Cardoso-Figueiredo R, Casares F, Chang A, Clandinin TR, Crasta S, Desplan C, Detweiler AM, Dhakan DB, Donà E, Engert S, Floc'hlay S, George N, González-Segarra AJ, Groves AK, Gumbin S, Guo Y, Harris DE, Heifetz Y, Holtz SL, Horns F, Hudry B, Hung RJ, Jan YN, Jaszczak JS, Jefferis GSXE, Karkanias J, Karr TL, Katheder NS, Kezos J, Kim AA, Kim SK, Kockel L, Konstantinides N, Kornberg TB, Krause HM, Labott AT, Laturney M, Lehmann R, Leinwand S, Li J, Li JSS, Li K, Li K, Li L, Li T, Litovchenko M, Liu HH, Liu Y, Lu TC, Manning J, Mase A, Matera-Vatnick M, Matias NR, McDonough-Goldstein CE, McGeever A, McLachlan AD, Moreno-Roman P, Neff N, Neville M, Ngo S, Nielsen T, O'Brien CE, Osumi-Sutherland D, Özel MN, Papatheodorou I, Petkovic M, Pilgrim C, Pisco AO, Reisenman C, Sanders EN, Dos Santos G, Scott K, Sherlekar A, Shiu P, Sims D, Sit RV, Slaidina M, Smith HE, Sterne G, Su YH, Sutton D, Tamayo M, Tan M, Tastekin I, Treiber C, Vacek D, Vogler G, Waddell S, Wang W, Wilson RI, Wolfner MF, Wong YE, Xie A, Xu J, Yamamoto S, Yan J, Yao Z, Yoda K, Zhu R, Zinzen RP. PMID: 35239393; PMCID: PMC8944923.
      View in: PubMed   Mentions: 426     Fields:    Translation:AnimalsCells
    22. Identification of a conserved drug binding pocket in TMEM16 proteins. Res Sq. 2022 Feb 10. Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L. PMID: 35169791; PMCID: PMC8845511.
      View in: PubMed   Mentions:
    23. Underrepresentation of Asian awardees of United States biomedical research prizes. Cell. 2022 02 03; 185(3):407-410. Jan YN. PMID: 35120660.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway. Elife. 2021 05 21; 10. Chou SM, Li KX, Huang MY, Chen C, Lin King YH, Li GG, Zhou W, Teo CF, Jan YN, Jan LY, Yang SB. PMID: 34018923; PMCID: PMC8208815.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    25. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY. PMID: 33972431; PMCID: PMC8157992.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    26. Interorganelle communication, aging, and neurodegeneration. Genes Dev. 2021 04 01; 35(7-8):449-469. Petkovic M, O'Brien CE, Jan YN. PMID: 33861720; PMCID: PMC8015714.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    27. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020 11 25; 108(4):640-650.e4. Wang P, Jia Y, Liu T, Jan YN, Zhang W. PMID: 32910893; PMCID: PMC8386590.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    28. TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 07 03; 11(1):3298. Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN. PMID: 32620747; PMCID: PMC7335067.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    29. Chloride channels regulate differentiation and barrier functions of the mammalian airway. Elife. 2020 04 14; 9. He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. PMID: 32286221; PMCID: PMC7182432.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    30. Mechanisms of neurite repair. Curr Opin Neurobiol. 2020 08; 63:53-58. Liu HH, Jan YN. PMID: 32278210; PMCID: PMC7534396.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    31. Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms. Annu Rev Neurosci. 2020 07 08; 43:207-229. Jin P, Jan LY, Jan YN. PMID: 32084327.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    32. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes Dev. 2020 02 01; 34(3-4):194-208. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y. PMID: 31919191; PMCID: PMC7000917.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors. Genes Dev. 2019 12 01; 33(23-24):1739-1750. Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN. PMID: 31753914; PMCID: PMC6942049.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 09 04; 8. Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. PMID: 31482844; PMCID: PMC6746550.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31365878; PMCID: PMC6690723.
      View in: PubMed   Mentions: 9     Fields:    
    36. TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. J Neurosci. 2019 09 04; 39(36):7102-7117. Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY. PMID: 31320449; PMCID: PMC6733546.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 07 18; 8. Ye W, Han TW, He M, Jan YN, Jan LY. PMID: 31318330; PMCID: PMC6690719.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    38. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31319050.
      View in: PubMed   Mentions: 10     Fields:    
    39. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 07 09; 28(2):567-579.e4. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31291589; PMCID: PMC6684876.
      View in: PubMed   Mentions: 63     Fields:    
    40. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586; PMCID: PMC6600921.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    41. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31151773; PMCID: PMC6639135.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    42. JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. Development. 2019 04 17; 146(8). Zhu S, Chen R, Soba P, Jan YN. PMID: 30936183; PMCID: PMC6503988.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    43. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 04 17; 102(2):373-389.e6. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. PMID: 30819546; PMCID: PMC6487666.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    44. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. PMID: 30804200; PMCID: PMC6421456.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    45. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. PMID: 30622179; PMCID: PMC6347726.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    46. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10748-E10757. Kwon MJ, Han MH, Bagley JA, Hyeon DY, Ko BS, Lee YM, Cha IJ, Kim SY, Kim DY, Kim HM, Hwang D, Lee SB, Jan YN. PMID: 30348793; PMCID: PMC6233066.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    47. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 06 04; 150(6):773-775. Jan LY, Jan YN. PMID: 29769227; PMCID: PMC5987881.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    48. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. PMID: 29563183; PMCID: PMC5900713.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    49. Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470. Jan YN, Jan LY. PMID: 29469134.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    50. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. PMID: 29478917; PMCID: PMC5860880.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    51. Force-activated ion channels in close-up. Nature. 2018 Feb; 554(7693):469-470. Jan YN, Jan LY. PMID: 32094930.
      View in: PubMed   Mentions:    Fields:    
    52. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. PMID: 29382763; PMCID: PMC5816197.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    53. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684; PMCID: PMC5750132.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    54. Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11161-E11169. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. PMID: 29229864; PMCID: PMC5748203.
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    384. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 1991 Nov 29; 67(5):941-53. Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN. PMID: 1720353.
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    385. The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 1991 Oct; 10(10):2975-83. Boulianne GL, de la Concha A, Campos-Ortega JA, Jan LY, Jan YN. PMID: 1717258; PMCID: PMC453012.
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    386. Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature. 1991 Sep 05; 353(6339):86-90. Isacoff EY, Jan YN, Jan LY. PMID: 1881453.
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    387. Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation. Genes Dev. 1991 Sep; 5(9):1577-88. Rao Y, Vaessin H, Jan LY, Jan YN. PMID: 1885000.
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    388. Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel. Neuron. 1991 Sep; 7(3):471-83. Baldwin TJ, Tsaur ML, Lopez GA, Jan YN, Jan LY. PMID: 1840649.
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    389. Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell. 1991 Aug 09; 66(3):433-49. Ruohola H, Bremer KA, Baker D, Swedlow JR, Jan LY, Jan YN. PMID: 1907889.
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    390. Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels. Neuron. 1991 Aug; 7(2):327-36. Lopez GA, Jan YN, Jan LY. PMID: 1873032.
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    391. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 1991 Jul; 5(7):1124-35. Blochlinger K, Jan LY, Jan YN. PMID: 1676691.
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    392. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 1991 Jan 24; 349(6307):305-10. Papazian DM, Timpe LC, Jan YN, Jan LY. PMID: 1846229.
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    393. Genetic and molecular bases of neurogenesis in Drosophila melanogaster. Annu Rev Neurosci. 1991; 14:399-420. Campos-Ortega JA, Jan YN. PMID: 1903242.
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    394. Genes required for specifying cell fates in Drosophila embryonic sensory nervous system. Trends Neurosci. 1990 Dec; 13(12):493-8. Jan YN, Jan LY. PMID: 1703680.
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    395. A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990 Nov; 110(3):661-9. Bodmer R, Jan LY, Jan YN. PMID: 1982429.
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    396. How might the diversity of potassium channels be generated? Trends Neurosci. 1990 Oct; 13(10):415-9. Jan LY, Jan YN. PMID: 1700515.
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    397. Differentiation-related alterations in the plasma membranes of chemically transformed murine fibroblasts. Anticancer Res. 1990 Sep-Oct; 10(5A):1319-28. Chakrabarty S, Jan Y, Varani J. PMID: 2241109.
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    398. Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos. Genes Dev. 1990 Aug; 4(8):1322-31. Blochlinger K, Bodmer R, Jan LY, Jan YN. PMID: 1977661.
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    399. A superfamily of ion channels. Nature. 1990 Jun 21; 345(6277):672. Jan LY, Jan YN. PMID: 1694264.
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    400. Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature. 1990 Jun 07; 345(6275):530-4. Isacoff EY, Jan YN, Jan LY. PMID: 2112229.
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    401. Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development. 1990 Jun; 109(2):425-33. Hay B, Jan LY, Jan YN. PMID: 2119289.
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    402. Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990 May 10; 345(6271):163-7. Rao Y, Jan LY, Jan YN. PMID: 1692392.
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    403. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 1990 Feb; 4(2):190-203. Bier E, Jan LY, Jan YN. PMID: 2110920.
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    404. Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila. Neuron. 1990 Jan; 4(1):119-27. Schwarz TL, Papazian DM, Carretto RC, Jan YN, Jan LY. PMID: 2310570.
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    405. Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol. 1990; 55:239-45. Vaessin H, Caudy M, Bier E, Jan LY, Jan YN. PMID: 2132818.
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    406. Molecular studies of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1990; 55:9-17. Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY. PMID: 2132867.
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    407. Fibronectin/laminin and their receptors in aberrant growth control in FR3T3 cells transformed by Ha-ras oncogene and epidermal growth factor gene. Int J Cancer. 1989 Aug 15; 44(2):325-31. Chakrabarty S, Jan Y, Levine A, McClenic B, Varani J. PMID: 2527209.
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    408. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11; 58(3):537-44. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB, et al. PMID: 2503252.
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    409. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 1989 Jul 28; 58(2):349-60. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. PMID: 2752427.
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    410. Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages. Neuron. 1989 Jul; 3(1):21-32. Bodmer R, Carretto R, Jan YN. PMID: 2515889.
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    411. Diverse cellular responses elicited from human colon carcinoma cells by transforming growth factor-beta. Cancer Res. 1989 Apr 15; 49(8):2112-7. Chakrabarty S, Jan Y, Brattain MG, Tobon A, Varani J. PMID: 2539253.
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    412. Voltage-sensitive ion channels. Cell. 1989 Jan 13; 56(1):13-25. Jan LY, Jan YN. PMID: 2463091.
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    413. daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell. 1988 Dec 23; 55(6):1061-7. Caudy M, Vässin H, Brand M, Tuma R, Jan LY, Jan YN. PMID: 3203380.
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    414. The determination of sense organs in Drosophila: interaction of scute with daughterless. Rouxs Arch Dev Biol. 1988 Dec; 197(7):419-423. Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 28305749.
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    415. A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell. 1988 Nov 18; 55(4):577-87. Hay B, Jan LY, Jan YN. PMID: 3052853.
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    416. A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J. 1988 Nov; 7(11):3471-7. Katz F, Moats W, Jan YN. PMID: 2463162; PMCID: PMC454847.
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    417. Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes. Neuron. 1988 Oct; 1(8):659-67. Timpe LC, Jan YN, Jan LY. PMID: 3272184.
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    418. Identification of a component of Drosophila polar granules. Development. 1988 Aug; 103(4):625-40. Hay B, Ackerman L, Barbel S, Jan LY, Jan YN. PMID: 3150351.
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    419. The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev. 1988 Jul; 2(7):843-52. Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 3209070.
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    420. Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature. 1988 Jun 16; 333(6174):629-35. Blochlinger K, Bodmer R, Jack J, Jan LY, Jan YN. PMID: 2897632.
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    421. Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science. 1988 May 13; 240(4854):913-6. Bier E, Ackerman L, Barbel S, Jan L, Jan YN. PMID: 3129785.
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    422. Cloning of a probable potassium channel gene from mouse brain. Nature. 1988 Apr 28; 332(6167):837-9. Tempel BL, Jan YN, Jan LY. PMID: 2451788.
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    423. Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature. 1988 Jan 14; 331(6152):137-42. Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448635.
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    424. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature. 1988 Jan 14; 331(6152):143-5. Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY. PMID: 2448636.
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    425. Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J Neurosci. 1987 Dec; 7(12):4195-200. Branton WD, Kolton L, Jan YN, Jan LY. PMID: 2826721; PMCID: PMC6569098.
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    426. Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell. 1987 Oct 23; 51(2):293-307. Bodmer R, Barbel S, Sheperd S, Jack JW, Jan LY, Jan YN. PMID: 3117374.
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    427. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 1987 Aug 14; 237(4816):770-5. Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY. PMID: 2441471.
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    428. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science. 1987 Aug 14; 237(4816):749-53. Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY. PMID: 2441470.
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    429. Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta. Proc Natl Acad Sci U S A. 1987 May; 84(10):3506-10. Bowers CW, Phillips HS, Lee P, Jan YN, Jan LY. PMID: 3033650; PMCID: PMC304900.
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    430. Morphological differentiation of the embryonic peripheral neurons in Drosophila. Rouxs Arch Dev Biol. 1987 Feb; 196(2):69-77. Bodmer R, Jan YN. PMID: 28305460.
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    431. Muscle connections between imaginal discs in Drosophila. Dev Biol. 1986 Feb; 113(2):288-94. Dambly-Chaudière C, Ghysen A, Jan YN, Jan LY. PMID: 3081389.
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    432. The LHRH family of peptide messengers in the frog nervous system. Prog Brain Res. 1986; 68:205-15. Branton WD, Phillips HS, Jan YN. PMID: 3550890.
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    433. Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J Neurosci. 1985 Sep; 5(9):2453-64. Jan YN, Ghysen A, Christoph I, Barbel S, Jan LY. PMID: 3928832; PMCID: PMC6565306.
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    434. Selective phosphorylation of cytosol proteins associated with transformation and restoration of normal phenotype in AKR mouse embryo fibroblasts. Cancer Res. 1985 May; 45(5):2170-6. Chakrabarty S, Jan Y, Son J, Miller CA, Brattain MG. PMID: 3872713.
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    435. Segmental determination in Drosophila central nervous system. Cell. 1985 Apr; 40(4):943-8. Ghysen A, Jan LY, Jan YN. PMID: 3886161.
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    436. Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:233-45. Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN. PMID: 6327158.
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    437. Peptides in neuronal function: studies using frog autonomic ganglia. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:363-74. Jan YN, Bowers CW, Branton D, Evans L, Jan LY. PMID: 6327165.
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    438. Some features of peptidergic transmission. Prog Brain Res. 1983; 58:49-59. Jan YN, Jan LY. PMID: 6138814.
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    439. Peptidergic transmission in sympathetic ganglia of the frog. J Physiol. 1982 Jun; 327:219-46. Jan LY, Jan YN. PMID: 6181250; PMCID: PMC1225105.
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    440. Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A. 1982 Apr; 79(8):2700-4. Jan LY, Jan YN. PMID: 6806816; PMCID: PMC346269.
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    441. Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1982; 1(11):1373-9. Ghysen A, Dambly-Chaudière C, Jan LY, Jan YN. PMID: 16453437; PMCID: PMC553219.
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    442. Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog. Fed Proc. 1981 Sep; 40(11):2560-4. Jan LY, Jan YN. PMID: 6115771.
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    443. Peptidergic transmitters in synaptic boutons of sympathetic ganglia. Nature. 1980 Nov 27; 288(5789):380-2. Jan LY, Jan YN, Brownfield MS. PMID: 6107864.
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    444. Further evidence for peptidergic transmission in sympathetic ganglia. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):5008-12. Jan YN, Jan LY, Kuffler SW. PMID: 6254052; PMCID: PMC349979.
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    445. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol. 1979 May; 81(2):275-300. Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L, Evans L. PMID: 38256; PMCID: PMC2110310.
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    446. A peptide as a possible transmitter in sympathetic ganglia of the frog. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1501-5. Jan YN, Jan LY, Kuffler SW. PMID: 35789; PMCID: PMC383282.
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    447. A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):4047-51. Wu CF, Ganetzky B, Jan LY, Jan YN, Benzer S. PMID: 211514; PMCID: PMC392928.
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    448. Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):515-9. Jan YN, Jan LY. PMID: 24218; PMCID: PMC411281.
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    449. Two mutations of synaptic transmission in Drosophila. Proc R Soc Lond B Biol Sci. 1977 Jul 28; 198(1130):87-108. Jan YN, Jan LY, Dennis MJ. PMID: 20636.
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    450. L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J Physiol. 1976 Oct; 262(1):215-36. Jan LY, Jan YN. PMID: 186587; PMCID: PMC1307638.
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    451. Properties of the larval neuromuscular junction in Drosophila melanogaster. J Physiol. 1976 Oct; 262(1):189-214. Jan LY, Jan YN. PMID: 11339; PMCID: PMC1307637.
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    452. dunce, a mutant of Drosophila deficient in learning. Proc Natl Acad Sci U S A. 1976 May; 73(5):1684-8. Dudai Y, Jan YN, Byers D, Quinn WG, Benzer S. PMID: 818641; PMCID: PMC430364.
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    453. Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces. J Gen Physiol. 1975 Jul; 66(1):67-95. Cohen RJ, Jan YN, Matricon J, Delbrück M. PMID: 1159403; PMCID: PMC2226190.
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    454. [Bacterial endocarditis in children associated with congenital cardiopathies: clinical aspects and outcome. Apropos of 22 cases]. Arch Fr Pediatr. 1974 Dec; 31(10):955-71. Jan Y, Loth P. PMID: 4463929.
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