Yuh Nung Jan, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-502-0725
ORCID ORCID Icon0000-0003-1367-6299 Additional info
vCardDownload vCard
    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Dendrite morphogenesis, function and regeneration
    NIH R35NS097227Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Molecular mechanisms of dendrite development in mammalian CNS
    NIH R01MH084234Jan 1, 2004 - Jan 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of dendrite development in mammalia
    NIH R01NS047200Jan 1, 2004 - Dec 31, 2007
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R37NS040929Jan 18, 2001 - Dec 31, 2016
    Role: Principal Investigator
    Genetic Dissection of Dendrite Development
    NIH R01NS040929Jan 18, 2001 - Nov 30, 2009
    Role: Principal Investigator
    LONGTERM CHANGES IN THE MAMMALIAN BRAIN
    NIH P50MH048200Sep 1, 1991 - Aug 31, 2002
    Role: Co-Investigator
    SLOW POTENTIALS IN AUTONOMIC GANGLIA
    NIH R01NS015757Dec 1, 1979 - Jun 30, 1988
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway. Elife. 2021 May 21; 10. Chou SM, Li KX, Huang MY, Chen C, Lin King YH, Li GG, Zhou W, Teo CF, Jan YN, Jan LY, Yang SB. PMID: 34018923.
      View in: PubMed   Mentions:    Fields:    
    2. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proc Natl Acad Sci U S A. 2021 May 18; 118(20). Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY. PMID: 33972431.
      View in: PubMed   Mentions:    Fields:    
    3. Interorganelle communication, aging, and neurodegeneration. Genes Dev. 2021 Apr 01; 35(7-8):449-469. Petkovic M, O'Brien CE, Jan YN. PMID: 33861720.
      View in: PubMed   Mentions:    Fields:    
    4. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020 11 25; 108(4):640-650.e4. Wang P, Jia Y, Liu T, Jan YN, Zhang W. PMID: 32910893.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 07 03; 11(1):3298. Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN. PMID: 32620747.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Chloride channels regulate differentiation and barrier functions of the mammalian airway. Elife. 2020 04 14; 9. He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. PMID: 32286221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Mechanisms of neurite repair. Curr Opin Neurobiol. 2020 08; 63:53-58. Liu HH, Jan YN. PMID: 32278210.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms. Annu Rev Neurosci. 2020 07 08; 43:207-229. Jin P, Jan LY, Jan YN. PMID: 32084327.
      View in: PubMed   Mentions: 11     Fields:    
    9. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes Dev. 2020 02 01; 34(3-4):194-208. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y. PMID: 31919191.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors. Genes Dev. 2019 12 01; 33(23-24):1739-1750. Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN. PMID: 31753914.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 09 04; 8. Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. PMID: 31482844.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31365878.
      View in: PubMed   Mentions: 4     Fields:    
    13. TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. J Neurosci. 2019 09 04; 39(36):7102-7117. Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY. PMID: 31320449.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 07 18; 8. Ye W, Han TW, He M, Jan YN, Jan LY. PMID: 31318330.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    15. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31319050.
      View in: PubMed   Mentions: 2     Fields:    
    16. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 07 09; 28(2):567-579.e4. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. PMID: 31291589.
      View in: PubMed   Mentions: 16     Fields:    
    17. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31151773.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. Development. 2019 04 17; 146(8). Zhu S, Chen R, Soba P, Jan YN. PMID: 30936183.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 04 17; 102(2):373-389.e6. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. PMID: 30819546.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. PMID: 30804200.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. PMID: 30622179.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10748-E10757. Kwon MJ, Han MH, Bagley JA, Hyeon DY, Ko BS, Lee YM, Cha IJ, Kim SY, Kim DY, Kim HM, Hwang D, Lee SB, Jan YN. PMID: 30348793.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 06 04; 150(6):773-775. Jan LY, Jan YN. PMID: 29769227.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. PMID: 29563183.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470. Jan YN, Jan LY. PMID: 29469134.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    27. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. PMID: 29478917.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Force-activated ion channels in close-up. Nature. 2018 Feb; 554(7693):469-470. Jan YN, Jan LY. PMID: 32094930.
      View in: PubMed   Mentions:    Fields:    
    29. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. PMID: 29382763.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    30. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. PMID: 29236684.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    31. Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11161-E11169. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. PMID: 29229864.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. PMID: 29212016.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    33. Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Cell Rep. 2017 Oct 24; 21(4):859-866. Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN. PMID: 29069593.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity. Cell Rep. 2017 Aug 22; 20(8):1855-1866. Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW. PMID: 28834749.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature. 2017 07 06; 547(7661):118-122. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. PMID: 28658211.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    36. Age-dependent diastolic heart failure in an in vivo Drosophila model. Elife. 2017 03 22; 6. Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN. PMID: 28328397.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    37. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18; 93(2):379-393. Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. PMID: 28065648.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    38. A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles. J Neurosci. 2016 11 02; 36(44):11275-11282. Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN. PMID: 27807168.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels. J Physiol. 2016 11 15; 594(22):6701-6713. Thayer DA, Yang SB, Jan YN, Jan LY. PMID: 27377235.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. In vivo dendrite regeneration after injury is different from dendrite development. Genes Dev. 2016 08 01; 30(15):1776-89. Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN. PMID: 27542831.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7243-8. Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z. PMID: 27298354.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    42. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    43. Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron. 2016 Feb 17; 89(4):741-55. Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN. PMID: 26853303.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. PMID: 26549191.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    45. Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons. PLoS Genet. 2015 Nov; 11(11):e1005642. Lin T, Pan PY, Lai YT, Chiang KW, Hsieh HL, Wu YP, Ke JM, Lee MC, Liao SS, Shih HT, Tang CY, Yang SB, Cheng HC, Wu JT, Jan YN, Lee HH. PMID: 26540204.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    46. Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel. Cell. 2015 Sep 10; 162(6):1391-403. Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN. PMID: 26359990.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    47. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. PMID: 26258683.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. PMID: 26098020.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    49. Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. PMID: 25961792.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    50. The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. Elife. 2015 Mar 12; 4. Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN. PMID: 25764303.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    51. Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3338-43. To TL, Piggott BJ, Makhijani K, Yu D, Jan YN, Shu X. PMID: 25733847.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    52. Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3547-52. Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY. PMID: 25733897.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    53. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 03; 84(5):968-82. Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. PMID: 25456499.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    54. Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila. Cell Rep. 2014 Nov 20; 9(4):1446-58. Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN. PMID: 25456135.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    55. Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. Elife. 2014 Oct 30; 3. Zhang W, Yan Z, Li B, Jan LY, Jan YN. PMID: 25358089.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    56. Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 2014 Sep 01; 28(17):1940-56. Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN. PMID: 25184680.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    57. A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife. 2014 Jun 30; 3. Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. PMID: 24980701.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    58. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. PMID: 24832154.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    59. Krüppel mediates the selective rebalancing of ion channel expression. Neuron. 2014 May 07; 82(3):537-44. Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW. PMID: 24811378.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    60. Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7331-6. Rumpf S, Bagley JA, Thompson-Peer KL, Zhu S, Gorczyca D, Beckstead RB, Jan LY, Jan YN. PMID: 24799714.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    61. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014 Feb 05; 81(3):544-560. Han C, Song Y, Xiao H, Wang D, Franc NC, Jan LY, Jan YN. PMID: 24412417.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    62. A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating. Neuron. 2013 Dec 04; 80(5):1190-205. Kim WJ, Jan LY, Jan YN. PMID: 24314729.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    63. Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila. Nat Neurosci. 2014 Jan; 17(1):81-8. Yuan Q, Song Y, Yang CH, Jan LY, Jan YN. PMID: 24241395.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    64. Subdued, a TMEM16 family Ca²?-activated Cl?channel in Drosophila melanogaster with an unexpected role in host defense. Elife. 2013 Nov 05; 2:e00862. Wong XM, Younger S, Peters CJ, Jan YN, Jan LY. PMID: 24192034.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    65. Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13612-7. Zhang W, Yan Z, Jan LY, Jan YN. PMID: 23898199.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    66. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. PMID: 23872594.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    67. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6352-7. Tien J, Lee HY, Minor DL, Jan YN, Jan LY. PMID: 23576756.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    68. Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1482-7. Thayer DA, Jan YN, Jan LY. PMID: 23297202.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    69. Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431):221-5. Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN. PMID: 23222543.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    70. Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron. 2012 Dec 06; 76(5):921-30. Ori-McKenney KM, Jan LY, Jan YN. PMID: 23217741.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    71. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. PMID: 23021219.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    72. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. PMID: 22988107.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    73. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. PMID: 22884327.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    74. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. PMID: 22855790.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    75. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 2012 Jul 15; 26(14):1612-25. Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN. PMID: 22759636.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    76. Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals. Nat Neurosci. 2012 Jun; 15(6):876-83. Kim WJ, Jan LY, Jan YN. PMID: 22561453.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    77. Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron. 2012 Apr 12; 74(1):179-92. Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY. PMID: 22500639.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    78. Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80. Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. PMID: 22456708.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    79. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012 Mar 22; 73(6):1127-42. Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. PMID: 22445341.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    80. Voltage-gated potassium channels and the diversity of electrical signalling. J Physiol. 2012 Jun 01; 590(11):2591-9. Jan LY, Jan YN. PMID: 22431339.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    81. Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers. J Physiol. 2012 Jun 01; 590(11):2645-58. Yang SB, Mclemore KD, Tasic B, Luo L, Jan YN, Jan LY. PMID: 22411008.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    82. Yoshiki Hotta's influence. J Neurogenet. 2012 Mar; 26(1):3-4. Jan YN. PMID: 22263807.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    83. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron. 2012 Jan 12; 73(1):64-78. Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan YN. PMID: 22243747.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    84. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 2012; 3:1317. Fieni F, Lee SB, Jan YN, Kirichok Y. PMID: 23271651.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    85. Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20615-20. Zhu S, Barshow S, Wildonger J, Jan LY, Jan YN. PMID: 22143802.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    86. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl). 2012 May; 90(5):575-85. Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY. PMID: 22105852.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    87. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron. 2011 Nov 17; 72(4):630-42. Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY. PMID: 22099464.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    88. Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16795-800. Lee SB, Bagley JA, Lee HY, Jan LY, Jan YN. PMID: 21930920.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    89. Light-induced structural and functional plasticity in Drosophila larval visual system. Science. 2011 Sep 09; 333(6048):1458-62. Yuan Q, Xiang Y, Yan Z, Han C, Jan LY, Jan YN. PMID: 21903815.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    90. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. PMID: 21558368.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    91. Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9673-8. Han C, Jan LY, Jan YN. PMID: 21606367.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    92. Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1. J Neurosci. 2011 Mar 02; 31(9):3309-19. Ye B, Kim JH, Yang L, McLachlan I, Younger S, Jan LY, Jan YN. PMID: 21368042.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    93. Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development. 2011 Mar; 138(6):1153-60. Rumpf S, Lee SB, Jan LY, Jan YN. PMID: 21343367.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    94. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010 Dec 16; 468(7326):921-6. Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN. PMID: 21068723.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    95. The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron. 2010 Aug 12; 67(3):373-80. Cheng LE, Song W, Looger LL, Jan LY, Jan YN. PMID: 20696376.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    96. Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11074-9. Young DM, Schenk AK, Yang SB, Jan YN, Jan LY. PMID: 20534473.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    97. Branching out: mechanisms of dendritic arborization. Nat Rev Neurosci. 2010 May; 11(5):316-28. Jan YN, Jan LY. PMID: 20404840.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    98. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21413-8. Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY. PMID: 19965375.
      View in: PubMed   Mentions: 141     Fields:    Translation:Animals
    99. Patterning and organization of motor neuron dendrites in the Drosophila larva. Dev Biol. 2009 Dec 15; 336(2):213-21. Kim MD, Wen Y, Jan YN. PMID: 19818341.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    100. The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron. 2009 Sep 24; 63(6):788-802. Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN. PMID: 19778508.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    101. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009 Jul 30; 63(2):189-202. Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein AR, Shi SH. PMID: 19640478.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    102. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6363-8. Lee HH, Jan LY, Jan YN. PMID: 19329489.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    103. Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron. 2009 Feb 26; 61(4):519-26. Yang CH, Rumpf S, Xiang Y, Gordon MD, Song W, Jan LY, Jan YN. PMID: 19249273.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    104. Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):629-34. Chung HJ, Qian X, Ehlers M, Jan YN, Jan LY. PMID: 19118198.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    105. G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):635-40. Chung HJ, Ge WP, Qian X, Wiser O, Jan YN, Jan LY. PMID: 19118199.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    106. Dividing glial cells maintain differentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):328-33. Ge WP, Zhou W, Luo Q, Jan LY, Jan YN. PMID: 19104058.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    107. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell. 2008 Sep 19; 134(6):1019-29. Schroeder BC, Cheng T, Jan YN, Jan LY. PMID: 18805094.
      View in: PubMed   Mentions: 527     Fields:    Translation:HumansAnimalsCells
    108. The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev. 2008 Sep 15; 22(18):2447-53. Wildonger J, Jan LY, Jan YN. PMID: 18794342.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    109. Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol. 2008 Oct; 10(10):1172-80. Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN. PMID: 18758451.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    110. Efficient ends-out gene targeting in Drosophila. Genetics. 2008 Sep; 180(1):703-7. Huang J, Zhou W, Watson AM, Jan YN, Hong Y. PMID: 18757917.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    111. Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes Dev. 2008 Jun 15; 22(12):1591-6. Sokol NS, Xu P, Jan YN, Ambros V. PMID: 18559475.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    112. Drosophila egg-laying site selection as a system to study simple decision-making processes. Science. 2008 Mar 21; 319(5870):1679-83. Yang CH, Belawat P, Hafen E, Jan LY, Jan YN. PMID: 18356529.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    113. Retrospective: Seymour Benzer (1921-2007). Science. 2008 Jan 04; 319(5859):45. Jan YN, Jan L. PMID: 18174427.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    114. An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One. 2007 Nov 28; 2(11):e1221. Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN, Kong YY. PMID: 18043734.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    115. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18079-84. Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M. PMID: 17989219.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    116. Growing dendrites and axons differ in their reliance on the secretory pathway. Cell. 2007 Aug 24; 130(4):717-29. Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN. PMID: 17719548.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    117. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul; 10(7):819-27. Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N. PMID: 17589506.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    118. Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron. 2007 May 03; 54(3):403-16. Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY, Jan YN. PMID: 17481394.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    119. Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 2007 Apr 15; 21(8):956-72. Parrish JZ, Emoto K, Jan LY, Jan YN. PMID: 17437999.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    120. Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5199-204. Song W, Onishi M, Jan LY, Jan YN. PMID: 17360325.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    121. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007 Feb 09; 128(3):547-60. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. PMID: 17289573.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    122. Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu Rev Neurosci. 2007; 30:399-423. Parrish JZ, Emoto K, Kim MD, Jan YN. PMID: 17378766.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    123. Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development. 2007 Jan; 134(1):55-64. Grueber WB, Ye B, Yang CH, Younger S, Borden K, Jan LY, Jan YN. PMID: 17164414.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    124. Structure prediction for the down state of a potassium channel voltage sensor. Nature. 2007 Feb 01; 445(7127):550-3. Grabe M, Lai HC, Jain M, Jan YN, Jan LY. PMID: 17187053.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    125. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell. 2006 Dec 15; 127(6):1253-64. Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN. PMID: 17174898.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    126. The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron. 2006 Dec 07; 52(5):803-16. Gu C, Zhou W, Puthenveedu MA, Xu M, Jan YN, Jan LY. PMID: 17145502.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    127. SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17548-53. Fay AJ, Qian X, Jan YN, Jan LY. PMID: 17085590.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    128. The secretory pathway and neuron polarization. J Neurosci. 2006 Oct 18; 26(42):10631-2. Ye B, Zhang YW, Jan LY, Jan YN. PMID: 17050701.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    129. Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science. 2006 Oct 06; 314(5796):144-8. Raab-Graham KF, Haddick PC, Jan YN, Jan LY. PMID: 17023663.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    130. The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev. 2006 Oct 15; 20(20):2806-19. Kim MD, Jan LY, Jan YN. PMID: 17015425.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    131. K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14361-6. Grabe M, Bichet D, Qian X, Jan YN, Jan LY. PMID: 16983068.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    132. Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14355-60. Bichet D, Grabe M, Jan YN, Jan LY. PMID: 16983069.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    133. The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature. 2006 Sep 14; 443(7108):210-3. Emoto K, Parrish JZ, Jan LY, Jan YN. PMID: 16906135.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    134. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron. 2006 Aug 03; 51(3):283-90. Kuo CT, Zhu S, Younger S, Jan LY, Jan YN. PMID: 16880123.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    135. Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron. 2006 Jul 06; 51(1):13-20. Yu F, Kuo CT, Jan YN. PMID: 16815328.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    136. Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8870-5. Chung HJ, Jan YN, Jan LY. PMID: 16735477.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    137. The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr Biol. 2006 May 23; 16(10):1006-11. Sweeney NT, Brenman JE, Jan YN, Gao FB. PMID: 16713958.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    138. Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron. 2006 May 18; 50(4):561-73. Wiser O, Qian X, Ehlers M, Ja WW, Roberts RW, Reuveny E, Jan YN, Jan LY. PMID: 16701207.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    139. Visualizing the breaking of symmetry. Dev Cell. 2006 Apr; 10(4):411-2. Ye B, Jan YN. PMID: 16580986.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    140. Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 2006 Apr 01; 20(7):820-35. Parrish JZ, Kim MD, Jan LY, Jan YN. PMID: 16547170.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    141. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17828-33. Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. PMID: 16319223.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    142. Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell. 2005 Oct 07; 123(1):105-18. Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY. PMID: 16213216.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    143. Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15230-5. Kuo CT, Jan LY, Jan YN. PMID: 16210248.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    144. The development of neuronal morphology in insects. Curr Biol. 2005 Sep 06; 15(17):R730-8. Grueber WB, Yang CH, Ye B, Jan YN. PMID: 16139206.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    145. The hand that rocks the spindle. Nat Cell Biol. 2005 Sep; 7(9):858-9. Kuo CT, Jan YN. PMID: 16136185.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    146. The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron. 2005 Aug 04; 47(3):395-406. Lai HC, Grabe M, Jan YN, Jan LY. PMID: 16055063.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    147. Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases. Mol Biol Cell. 2005 Sep; 16(9):4139-52. He Y, Emoto K, Fang X, Ren N, Tian X, Jan YN, Adler PN. PMID: 15975907.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    148. Mammalian electrophysiology on a microfluidic platform. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9112-7. Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP. PMID: 15967996.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    149. Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell. 2005 Aug; 16(8):3480-7. Roegiers F, Jan LY, Jan YN. PMID: 15901829.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    150. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development. 2005 May; 132(10):2319-32. Lai EC, Roegiers F, Qin X, Jan YN, Rubin GM. PMID: 15829515.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    151. Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3834-9. Goldstein AY, Jan YN, Luo L. PMID: 15738386.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    152. The cadherin superfamily and dendrite development. Trends Cell Biol. 2005 Feb; 15(2):64-7. Ye B, Jan YN. PMID: 15695092.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    153. A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):965-70. Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY. PMID: 15657131.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    154. The Notch regulator Numb links the Notch and TCR signaling pathways. J Immunol. 2005 Jan 15; 174(2):890-7. Anderson AC, Kitchens EA, Chan SW, St Hill C, Jan YN, Zhong W, Robey EA. PMID: 15634911.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    155. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 2005 Jan 01; 19(1):138-51. Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN. PMID: 15598981.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    156. A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17640-5. Grabe M, Lecar H, Jan YN, Jan LY. PMID: 15591352.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    157. The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development. Mol Biol Cell. 2005 Feb; 16(2):689-700. He Y, Fang X, Emoto K, Jan YN, Adler PN. PMID: 15591127.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    158. APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr Biol. 2004 Nov 23; 14(22):2025-32. Shi SH, Cheng T, Jan LY, Jan YN. PMID: 15556865.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    159. Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell. 2004 Oct 15; 119(2):245-56. Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY, Jan YN. PMID: 15479641.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    160. The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13346-51. Shi SH, Cheng T, Jan LY, Jan YN. PMID: 15340156.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    161. Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13341-5. Shi SH, Cox DN, Wang D, Jan LY, Jan YN. PMID: 15340157.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    162. NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7799-804. Lin YF, Raab-Graham K, Jan YN, Jan LY. PMID: 15136749.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    163. Asymmetric cell division. Curr Opin Cell Biol. 2004 Apr; 16(2):195-205. Roegiers F, Jan YN. PMID: 15196564.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    164. Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4441-6. Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY. PMID: 15070737.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    165. Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev. 2004 Mar 15; 18(6):623-8. Moore AW, Roegiers F, Jan LY, Jan YN. PMID: 15075290.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    166. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21. Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN. PMID: 14972682.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    167. Dendritic development: lessons from Drosophila and related branches. Curr Opin Neurobiol. 2004 Feb; 14(1):74-82. Grueber WB, Jan YN. PMID: 15018941.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    168. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 2004 Feb; 36(2):197-204. McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI, Li H. PMID: 14730301.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimals
    169. Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron. 2003 Dec 18; 40(6):1105-18. Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN. PMID: 14687546.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    170. Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12712-7. Hong Y, Ackerman L, Jan LY, Jan YN. PMID: 14569003.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    171. The control of dendrite development. Neuron. 2003 Oct 09; 40(2):229-42. Jan YN, Jan LY. PMID: 14556706.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    172. Cell biology: the hippo hypothesis. Nature. 2003 Oct 02; 425(6957):469-70. Rothenberg ME, Jan YN. PMID: 14523431.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    173. Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev. 2003 Sep-Oct; 5(5):532-41. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown NL. PMID: 12950631.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    174. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron. 2003 Aug 28; 39(5):779-91. Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN. PMID: 12948445.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    175. A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science. 2003 Aug 01; 301(5633):646-9. Gu C, Jan YN, Jan LY. PMID: 12893943.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    176. Yuh-Nung Jan. Curr Biol. 2003 May 13; 13(10):R378-9. Jan YN. PMID: 12747843.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    177. ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C. Neuron. 2003 May 08; 38(3):417-32. Hu K, Huang CS, Jan YN, Jan LY. PMID: 12741989.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    178. Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia. Development. 2003 May; 130(9):1927-35. Abdelilah-Seyfried S, Cox DN, Jan YN. PMID: 12642496.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    179. Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr Biol. 2003 Apr 29; 13(9):778-83. Justice N, Roegiers F, Jan LY, Jan YN. PMID: 12725738.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    180. Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol. 2003 Apr 15; 13(8):618-26. Grueber WB, Ye B, Moore AW, Jan LY, Jan YN. PMID: 12699617.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    181. A lethal giant kinase in cell polarity. Nat Cell Biol. 2003 Apr; 5(4):273-4. Justice NJ, Jan YN. PMID: 12669072.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    182. Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell. 2003 Mar 21; 112(6):805-18. Grueber WB, Jan LY, Jan YN. PMID: 12654247.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    183. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81. Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN. PMID: 12586070.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    184. Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell. 2003 Jan 10; 112(1):63-75. Shi SH, Jan LY, Jan YN. PMID: 12526794.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    185. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature. 2002 Oct 31; 419(6910):929-34. Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. PMID: 12410312.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    186. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development. 2002 Oct; 129(20):4843-53. Shen Q, Zhong W, Jan YN, Temple S. PMID: 12361975.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    187. Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol. 2002 Sep 17; 12(18):1605-10. Donovan J, Kordylewska A, Jan YN, Utset MF. PMID: 12372254.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    188. salvador--The persistence of proliferation. Cancer Cell. 2002 Sep; 2(3):171-3. Rothenberg ME, Jan YN. PMID: 12242148.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    189. hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology. Science. 2002 Aug 23; 297(5585):1355-8. Moore AW, Jan LY, Jan YN. PMID: 12193790.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    190. Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development. 2002 Jun; 129(12):2867-78. Grueber WB, Jan LY, Jan YN. PMID: 12050135.
      View in: PubMed   Mentions: 241     Fields:    Translation:AnimalsCells
    191. Probing protein electrostatics with a synthetic fluorescent amino acid. Science. 2002 May 31; 296(5573):1700-3. Cohen BE, McAnaney TB, Park ES, Jan YN, Boxer SG, Jan LY. PMID: 12040199.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    192. Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron. 2002 Feb 28; 33(5):715-29. Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY. PMID: 11879649.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    193. Variations on the Notch pathway in neural development. Curr Opin Neurobiol. 2002 Feb; 12(1):64-70. Justice NJ, Jan YN. PMID: 11861166.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    194. Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster. ScientificWorldJournal. 2001; 1:138. Zou S, Meadows S, Sharp L, Jan LY, Jan YN. PMID: 30147616.
      View in: PubMed   Mentions:    Fields:    
    195. A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos. Rouxs Arch Dev Biol. 1993 Aug; 202(6):371-381. Bodmer R, Jan LY, Jan YN. PMID: 28306050.
      View in: PubMed   Mentions:
    196. Tracing neurons with a kinesin-ß-galactosidase fusion protein. Rouxs Arch Dev Biol. 1993 Mar; 202(2):112-122. Giniger E, Wells W, Jan LY, Jan YN. PMID: 28305652.
      View in: PubMed   Mentions:
    197. Studying Drosophila embryogenesis with P-lacZ enhancer trap lines. Rouxs Arch Dev Biol. 1992 Jun; 201(4):194-220. Hartenstein V, Jan YN. PMID: 28305845.
      View in: PubMed   Mentions:
    198. The determination of sense organs in Drosophila: interaction of scute with daughterless. Rouxs Arch Dev Biol. 1988 Dec; 197(7):419-423. Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN. PMID: 28305749.
      View in: PubMed   Mentions:
    199. Morphological differentiation of the embryonic peripheral neurons in Drosophila. Rouxs Arch Dev Biol. 1987 Feb; 196(2):69-77. Bodmer R, Jan YN. PMID: 28305460.
      View in: PubMed   Mentions:
    Yuh Nung's Networks
    Concepts (716)
    Derived automatically from this person's publications.
    _
    Co-Authors (60)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _