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Shawn Douglas, PhD

Title(s)Associate Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street
San Francisco CA 94158
PronounsHe/Him/His
ORCID ORCID Icon0000-0001-5398-9041 Additional info
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    DNA Nanostructures for High-Throughput Cryo-EM Studies of Small Macromolecules
    NIH R35GM125027Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Using DNA Origami to Study Nanoscale Organization of Plasma Membranes. Nano Lett. 2026 Apr 20. Corradi E, Shen K, Karatas Z, Cercy M, Schlichthaerle T, Caumont M, Osouf M, Vialet B, Barthelemy P, Rosendale M, Radhakrishnan AV, Chen T, Jungmann R, Gissot A, Douglas SM, Giannone G. PMID: 42007734.
      View in: PubMed   Mentions:    Fields:    
    2. Design principles for accurate folding of DNA origami. Proc Natl Acad Sci U S A. 2024 Nov 26; 121(48):e2406769121. Aksel T, J Navarro E, Fong N, Douglas SM. PMID: 39570311; PMCID: PMC11621765.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. Engineering an Escherichia coli strain for production of long single-stranded DNA. Nucleic Acids Res. 2024 Apr 24; 52(7):4098-4107. Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM. PMID: 38499480; PMCID: PMC11040142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    4. Design principles for accurate folding of DNA origami. bioRxiv. 2024 Mar 19. Aksel T, Navarro EJ, Fong N, Douglas SM. PMID: 38562860; PMCID: PMC10983894.
      View in: PubMed   Mentions:
    5. Engineering an Escherichia coli strain for production of long single-stranded DNA. bioRxiv. 2024 Mar 01. Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM. PMID: 38464036; PMCID: PMC10925301.
      View in: PubMed   Mentions:
    6. Leveraging DNA Origami to Study Phagocytosis. Methods Mol Biol. 2023; 2654:303-312. Miller WD, Kern N, Douglas SM, Morrissey MA. PMID: 37106190.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation. Proc Natl Acad Sci U S A. 2021 10 05; 118(40). Dong R, Aksel T, Chan W, Germain RN, Vale RD, Douglas SM. PMID: 34588308; PMCID: PMC8501782.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    8. Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis. Elife. 2021 06 03; 10. Kern N, Dong R, Douglas SM, Vale RD, Morrissey MA. PMID: 34080973; PMCID: PMC8175083.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins. Nat Biotechnol. 2021 03; 39(3):378-386. Aksel T, Yu Z, Cheng Y, Douglas SM. PMID: 33077960; PMCID: PMC7956247.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    10. Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy. J Struct Biol. 2020 02 01; 209(2):107437. Wang F, Yu Z, Betegon M, Campbell MG, Aksel T, Zhao J, Li S, Douglas SM, Cheng Y, Agard DA. PMID: 31866389; PMCID: PMC7272056.
      View in: PubMed   Mentions: 35     Fields:    
    11. Construction of a novel phagemid to produce custom DNA origami scaffolds. Synth Biol (Oxf). 2018 Jan; 3(1). Nafisi PM, Aksel T, Douglas SM. PMID: 30984875; PMCID: PMC6461039.
      View in: PubMed   Mentions: 32  
    12. Bringing proteins into the fold. Science. 2017 03 24; 355(6331):1261-1262. Douglas SM. PMID: 28336623.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Folding complex DNA nanostructures from limited sets of reusable sequences. Nucleic Acids Res. 2016 06 20; 44(11):e102. Niekamp S, Blumer K, Nafisi PM, Tsui K, Garbutt J, Douglas SM. PMID: 27036861; PMCID: PMC4914096.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    14. A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):11920-7. Ball MP, Thakuria JV, Zaranek AW, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow MJ, Cano C, Chou MF, Chung WK, Douglas SM, Estep PW, Gore A, Hulick P, Labarga A, Lee JH, Lunshof JE, Kim BC, Kim JI, Li Z, Murray MF, Nilsen GB, Peters BA, Raman AM, Rienhoff HY, Robasky K, Wheeler MT, Vandewege W, Vorhaus DB, Yang JL, Yang L, Aach J, Ashley EA, Drmanac R, Kim SJ, Li JB, Peshkin L, Seidman CE, Seo JS, Zhang K, Rehm HL, Church GM. PMID: 22797899; PMCID: PMC3409785.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    15. A logic-gated nanorobot for targeted transport of molecular payloads. Science. 2012 Feb 17; 335(6070):831-4. Douglas SM, Bachelet I, Church GM. PMID: 22344439.
      View in: PubMed   Mentions: 557     Fields:    Translation:HumansAnimalsCells
    16. Multilayer DNA origami packed on a square lattice. J Am Chem Soc. 2009 Nov 04; 131(43):15903-8. Ke Y, Douglas SM, Liu M, Sharma J, Cheng A, Leung A, Liu Y, Shih WM, Yan H. PMID: 19807088; PMCID: PMC2821935.
      View in: PubMed   Mentions: 130     Fields:    Translation:Cells
    17. Folding DNA into twisted and curved nanoscale shapes. Science. 2009 Aug 07; 325(5941):725-30. Dietz H, Douglas SM, Shih WM. PMID: 19661424; PMCID: PMC2737683.
      View in: PubMed   Mentions: 373     Fields:    Translation:Cells
    18. Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic Acids Res. 2009 Aug; 37(15):5001-6. Douglas SM, Marblestone AH, Teerapittayanon S, Vazquez A, Church GM, Shih WM. PMID: 19531737; PMCID: PMC2731887.
      View in: PubMed   Mentions: 433     Fields:    Translation:Cells
    19. Erratum: Self-assembly of DNA into nanoscale three-dimensional shapes. Nature. 2009 Jun 1; 459(7250):1154-1154. Douglas DS, Dietz DH, Liedl LT, Högberg HB, Graf GF, Shih SW. .
      View in: Publisher Site   Mentions:
    20. Self-assembly of DNA into nanoscale three-dimensional shapes. Nature. 2009 May 21; 459(7245):414-8. Douglas SM, Dietz H, Liedl T, Högberg B, Graf F, Shih WM. PMID: 19458720; PMCID: PMC2688462.
      View in: PubMed   Mentions: 722     Fields:    Translation:Cells
    21. RNAi development. PLoS Comput Biol. 2007 Apr 27; 3(4):e80. Gerstein M, Douglas SM. PMID: 17465677; PMCID: PMC1857818.
      View in: PubMed   Mentions: 1     Fields:    
    22. DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6644-8. Douglas SM, Chou JJ, Shih WM. PMID: 17404217; PMCID: PMC1871839.
      View in: PubMed   Mentions: 138     Fields:    Translation:Cells
    23. Network security and data integrity in academia: an assessment and a proposal for large-scale archiving. Genome Biol. 2005; 6(9):119. Smith A, Greenbaum D, Douglas SM, Long M, Gerstein M. PMID: 16168090; PMCID: PMC1242199.
      View in: PubMed   Mentions: 5     Fields:    
    24. PubNet: a flexible system for visualizing literature derived networks. Genome Biol. 2005; 6(9):R80. Douglas SM, Montelione GT, Gerstein M. PMID: 16168087; PMCID: PMC1242215.
      View in: PubMed   Mentions: 29     Fields:    
    25. Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium. Methods Enzymol. 2005; 394:210-43. Acton TB, Gunsalus KC, Xiao R, Ma LC, Aramini J, Baran MC, Chiang YW, Climent T, Cooper B, Denissova NG, Douglas SM, Everett JK, Ho CK, Macapagal D, Rajan PK, Shastry R, Shih LY, Swapna GV, Wilson M, Wu M, Gerstein M, Inouye M, Hunt JF, Montelione GT. PMID: 15808222.
      View in: PubMed   Mentions: 85     Fields:    Translation:Cells
    26. Computer security in academia-a potential roadblock to distributed annotation of the human genome. Nat Biotechnol. 2004 Jun; 22(6):771-2. Greenbaum D, Douglas SM, Smith A, Lim J, Fischer M, Schultz M, Gerstein M. PMID: 15175700.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Mining the structural genomics pipeline: identification of protein properties that affect high-throughput experimental analysis. J Mol Biol. 2004 Feb 06; 336(1):115-30. Goh CS, Lan N, Douglas SM, Wu B, Echols N, Smith A, Milburn D, Montelione GT, Zhao H, Gerstein M. PMID: 14741208.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    28. SPINE 2: a system for collaborative structural proteomics within a federated database framework. Nucleic Acids Res. 2003 Jun 01; 31(11):2833-8. Goh CS, Lan N, Echols N, Douglas SM, Milburn D, Bertone P, Xiao R, Ma LC, Zheng D, Wunderlich Z, Acton T, Montelione GT, Gerstein M. PMID: 12771210; PMCID: PMC156730.
      View in: PubMed   Mentions: 25     Fields:    
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