Loading...

Ron Vale, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
Phone415-476-6380
vCardDownload vCard
    Other Positions
    TitleHoward Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    2014Institute of Medicine Member
    2012Albert Lasker Basic Medical Research Award

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Microtubule-Based Motility
    NIH R35GM118106Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Creating an online resource center for training and professional development in the biomedical sciences
    NIH R25GM116704Sep 25, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Structure and mechanism of the dynein motor
    NIH R01GM097312Apr 1, 2011 - Mar 31, 2019
    Role: Principal Investigator
    Open Source Microscopy Software
    NIH R01EB007187Apr 1, 2007 - Aug 31, 2015
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13GM085967Sep 20, 2004 - May 31, 2018
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13DK069546Sep 20, 2004 - Jul 31, 2007
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    PROTEIN MODULATORS OF MICROTUBULE DYNAMICS
    NIH R01GM049752Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Microtubule Complexes Involved in Intracelluar Transport
    NIH R37GM038499Feb 1, 1988 - Aug 31, 2016
    Role: Principal Investigator
    Macromoleclar Complexes Involved in Cellular Transport
    NIH R01GM038499Feb 1, 1988 - Aug 31, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Carbone CB, Vale R, Stuurman N. An acquisition and analysis pipeline for scanning angle interference microscopy. Nat Methods. 2016 Oct 31; 13(11):897-898. PMID: 27798596.
      View in: PubMed
    2. Schroeder CM, Vale R. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J Cell Biol. 2016 Aug 1; 214(3):309-18. PMID: 27482052.
      View in: PubMed
    3. Stuurman N, Vale R. Impact of New Camera Technologies on Discoveries in Cell Biology. Biol Bull. 2016 Aug; 231(1):5-13. PMID: 27638691.
      View in: PubMed
    4. Vale R, Hyman AA. Priority of discovery in the life sciences. Elife. 2016; 5. PMID: 27310529.
      View in: PubMed
    5. Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale R, VijayRaghavan K, Wolberger C. Preprints for the life sciences. Science. 2016 May 20; 352(6288):899-901. PMID: 27199406.
      View in: PubMed
    6. Yan X, Hoek TA, Vale R, Tanenbaum ME. Dynamics of Translation of Single mRNA Molecules In Vivo. Cell. 2016 May 5; 165(4):976-89. PMID: 27153498.
      View in: PubMed
    7. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale R, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 May 4; 90(3):551-63. PMID: 27112495.
      View in: PubMed
    8. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale R. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844.
      View in: PubMed
    9. McKenney RJ, Huynh W, Vale R, Sirajuddin M. Tyrosination of a-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 Jun 1; 35(11):1175-85. PMID: 26968983.
      View in: PubMed
    10. Bhabha G, Johnson GT, Schroeder CM, Vale R. How Dynein Moves Along Microtubules. Trends Biochem Sci. 2016 Jan; 41(1):94-105. PMID: 26678005.
      View in: PubMed
    11. Vale R. Accelerating scientific publication in biology. Proc Natl Acad Sci U S A. 2015 Nov 3; 112(44):13439-46. PMID: 26508643; PMCID: PMC4640799.
    12. Dell KR, Vale R. iBioChina and iBiology: spreading scientific knowledge together. Sci China Life Sci. 2015 Nov; 58(11):1180-2. PMID: 26423567.
      View in: PubMed
    13. Petry S, Vale R. Microtubule nucleation at the centrosome and beyond. Nat Cell Biol. 2015 Sep; 17(9):1089-93. PMID: 26316453.
      View in: PubMed
    14. Yildiz A, Vale R. Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep; 2015(9):pdb.prot086355. PMID: 26330626.
      View in: PubMed
    15. Yildiz A, Vale R. Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep; 2015(9):pdb.top086348. PMID: 26330632.
      View in: PubMed
    16. Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale R. Regulation of mRNA translation during mitosis. Elife. 2015; 4. PMID: 26305499; PMCID: PMC4548207.
    17. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale R, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35. PMID: 26125038; PMCID: PMC4479523.
    18. Ham H, Huynh W, Schoon RA, Vale R, Billadeau DD. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015 Apr 15; 194(8):3984-96. PMID: 25762780; PMCID: PMC4390494 [Available on 04/15/16].
    19. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale R. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 6; 159(4):857-68. PMID: 25417161; PMCID: PMC4269335.
    20. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale R. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. PMID: 25307933; PMCID: PMC4252608.
    21. Schroeder CM, Ostrem JM, Hertz NT, Vale R. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. Elife. 2014; 3:e03351. PMID: 25272277; PMCID: PMC4359372.
    22. Ribeiro SA, D'Ambrosio MV, Vale R. Induction of focal adhesions and motility in Drosophila S2 cells. Mol Biol Cell. 2014 Dec 1; 25(24):3861-9. PMID: 25273555; PMCID: PMC4244196.
    23. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale R. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. PMID: 25035494; PMCID: PMC4224444.
    24. Hendershott MC, Vale R. Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5860-5. PMID: 24706919; PMCID: PMC4000804.
    25. Sirajuddin M, Rice LM, Vale R. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat Cell Biol. 2014 Apr; 16(4):335-44. PMID: 24633327; PMCID: PMC4117587.
    26. Hui E, Vale R. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. PMID: 24463463; PMCID: PMC4062301.
    27. Toret CP, D'Ambrosio MV, Vale R, Simon MA, Nelson WJ. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014 Jan 20; 204(2):265-79. PMID: 24446484; PMCID: PMC3897182.
    28. Vale R. Preface: the role of reconstitution in cytoskeleton research. Methods Enzymol. 2014; 540:xix-xxiii. PMID: 24630122.
      View in: PubMed
    29. Moutinho-Pereira S, Stuurman N, Afonso O, Hornsveld M, Aguiar P, Goshima G, Vale R, Maiato H. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49):19808-13. PMID: 24255106; PMCID: PMC3856817.
    30. Doyle KM, Vale R. Creating opportunities for science PhDs to pursue careers in high school education. Mol Biol Cell. 2013 Nov; 24(21):3292-6. PMID: 24174464; PMCID: PMC3814146.
    31. Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2013 Sep 29; 13(10):807-809. PMID: 27684577.
      View in: PubMed
    32. Tanenbaum ME, Vale R, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013; 2:e00943. PMID: 24015359; PMCID: PMC3762337.
    33. Vale R. The value of asking questions. Mol Biol Cell. 2013 Mar; 24(6):680-2. PMID: 23486404; PMCID: PMC3596240.
    34. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale R. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77. PMID: 23415226; PMCID: PMC3680348.
    35. Vale R, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3. PMID: 23258877; PMCID: PMC3810400.
    36. Vale R. How lucky can one be? A perspective from a young scientist at the right place at the right time. Nat Med. 2012 Oct; 18(10):1486-8. PMID: 23042358.
      View in: PubMed
    37. Vale R. Evaluating how we evaluate. Mol Biol Cell. 2012 Sep; 23(17):3285-9. PMID: 22936699; PMCID: PMC3431935.
    38. James JR, Vale R. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature. 2012 Jul 5; 487(7405):64-9. PMID: 22763440; PMCID: PMC3393772.
    39. Zou W, Wang X, Vale R, Ou G. Autophagy genes promote apoptotic cell corpse clearance. Autophagy. 2012 Aug; 8(8):1267-8. PMID: 22653037.
      View in: PubMed
    40. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X, Vale R, Ou G. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012 Apr 2; 197(1):27-35. PMID: 22451698; PMCID: PMC3317810.
    41. Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale R, Jülicher F, Reck-Peterson SL, Dogterom M. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Feb 3; 148(3):502-14. PMID: 22304918; PMCID: PMC3292199.
    42. Petry S, Vale R. A new cap for kinetochore fibre minus ends. Nat Cell Biol. 2011 Dec; 13(12):1389-91. PMID: 22081093; PMCID: PMC3532025.
    43. Cho C, Vale R. The mechanism of dynein motility: insight from crystal structures of the motor domain. Biochim Biophys Acta. 2012 Jan; 1823(1):182-91. PMID: 22062687; PMCID: PMC3249483.
    44. Petry S, Pugieux C, Nédélec FJ, Vale R. Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14473-8. PMID: 21844347; PMCID: PMC3167534.
    45. Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale R, Prasad BC, Clark SG, Garriga G. The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr Biol. 2011 Jun 7; 21(11):948-54. PMID: 21596567; PMCID: PMC3109113.
    46. Carter AP, Cho C, Jin L, Vale R. Crystal structure of the dynein motor domain. Science. 2011 Mar 4; 331(6021):1159-65. PMID: 21330489; PMCID: PMC3169322.
    47. Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale R. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 2011 Mar 4; 286(9):7457-67. PMID: 21169635; PMCID: PMC3045001.
    48. Yudushkin IA, Vale R. Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3? in the endosomal compartment. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22128-33. PMID: 21135224; PMCID: PMC3009781.
    49. D'Ambrosio MV, Vale R. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Biol. 2010 Nov 1; 191(3):471-8. PMID: 21041442; PMCID: PMC3003316.
    50. Goodwin SS, Vale R. Patronin regulates the microtubule network by protecting microtubule minus ends. Cell. 2010 Oct 15; 143(2):263-74. PMID: 20946984; PMCID: PMC3008421.
    51. Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N. Computer control of microscopes using µManager. Curr Protoc Mol Biol. 2010 Oct; Chapter 14:Unit14.20. PMID: 20890901; PMCID: PMC3065365.
    52. Ou G, Stuurman N, D'Ambrosio M, Vale R. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010 Oct 29; 330(6004):677-80. PMID: 20929735; PMCID: PMC3032534.
    53. Tole S, Vale R. Young leaders for biology in India. Science. 2010 Sep 17; 329(5998):1441. PMID: 20847237.
      View in: PubMed
    54. Yu CH, Wu HJ, Kaizuka Y, Vale R, Groves JT. Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS One. 2010; 5(7):e11878. PMID: 20686692; PMCID: PMC2912367.
    55. Uehara R, Goshima G, Mabuchi I, Vale R, Spudich JA, Griffis ER. Determinants of myosin II cortical localization during cytokinesis. Curr Biol. 2010 Jun 22; 20(12):1080-5. PMID: 20541410; PMCID: PMC2930192.
    56. Carter AP, Vale R. Communication between the AAA+ ring and microtubule-binding domain of dynein. Biochem Cell Biol. 2010 Feb; 88(1):15-21. PMID: 20130675; PMCID: PMC2894566.
    57. Vale R. It's a wonderful life: a career as an academic scientist. Mol Biol Cell. 2010 Jan 1; 21(1):11-4. PMID: 20048258; PMCID: PMC2801704.
    58. Kardon JR, Vale R. Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol. 2009 Dec; 10(12):854-65. PMID: 19935668; PMCID: PMC3394690.
    59. Vale R, Spudich JA, Griffis ER. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol. 2009 Sep 7; 186(5):727-38. PMID: 19720876; PMCID: PMC2742194.
    60. DePristo MA, Chang L, Vale R, Khan SM, Lipkow K. Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy. Prog Biophys Mol Biol. 2009 Sep-Oct; 100(1-3):25-32. PMID: 19628003; PMCID: PMC2805826.
    61. Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale R. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol. 2009 May 4; 185(3):521-34. PMID: 19398758; PMCID: PMC2700390.
    62. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale R, Obuse C, Goshima G. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6998-7003. PMID: 19369198.
      View in: PubMed
    63. Ou G, Vale R. Molecular signatures of cell migration in C. elegans Q neuroblasts. J Cell Biol. 2009 Apr 6; 185(1):77-85. PMID: 19349580; PMCID: PMC2700521.
    64. Kardon JR, Reck-Peterson SL, Vale R. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5669-74. PMID: 19293377; PMCID: PMC2657088.
    65. Vale R, Dell K. The biological sciences in India: aiming high for the future. J Cell Biol. 2009 Feb 9; 184(3):342-53. PMID: 19204144; PMCID: PMC2646550.
    66. Gennerich A, Vale R. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb; 21(1):59-67. PMID: 19179063; PMCID: PMC2668149.
    67. Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale R, Gibbons IR. Structure and functional role of dynein's microtubule-binding domain. Science. 2008 Dec 12; 322(5908):1691-5. PMID: 19074350; PMCID: PMC2663340.
    68. Vale R. Microscopes for fluorimeters: the era of single molecule measurements. Cell. 2008 Nov 28; 135(5):779-85. PMID: 19041739; PMCID: PMC2762818.
    69. Yildiz A, Tomishige M, Gennerich A, Vale R. Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell. 2008 Sep 19; 134(6):1030-41. PMID: 18805095; PMCID: PMC2613771.
    70. Cho C, Reck-Peterson SL, Vale R. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem. 2008 Sep 19; 283(38):25839-45. PMID: 18650442; PMCID: PMC2533788.
    71. Goshima G, Mayer M, Zhang N, Stuurman N, Vale R. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol. 2008 May 5; 181(3):421-9. PMID: 18443220; PMCID: PMC2364697.
    72. Trammell MA, Mahoney NM, Agard DA, Vale R. Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci. 2008 Apr 15; 121(Pt 8):1284-92. PMID: 18388316; PMCID: PMC2851640.
    73. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale R, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709; PMCID: PMC2734507.
    74. Roll-Mecak A, Vale R. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature. 2008 Jan 17; 451(7176):363-7. PMID: 18202664; PMCID: PMC2882799.
    75. Douglass AD, Vale R. Single-molecule imaging of fluorescent proteins. Methods Cell Biol. 2008; 85:113-25. PMID: 18155461.
      View in: PubMed
    76. Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale R. Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20296-301. PMID: 18077330; PMCID: PMC2154425.
    77. Gennerich A, Carter AP, Reck-Peterson SL, Vale R. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Nov 30; 131(5):952-65. PMID: 18045537; PMCID: PMC2851641.
    78. Mori T, Vale R, Tomishige M. How kinesin waits between steps. Nature. 2007 Nov 29; 450(7170):750-4. PMID: 18004302.
      View in: PubMed
    79. Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. J Biol Chem. 2007 Nov 30; 282(48):34748-57. PMID: 17911103.
      View in: PubMed
    80. Slep KC, Vale R. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Mol Cell. 2007 Sep 21; 27(6):976-91. PMID: 17889670; PMCID: PMC2052927.
    81. Griffis ER, Stuurman N, Vale R. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007 Jun 18; 177(6):1005-15. PMID: 17576797; PMCID: PMC2064361.
    82. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale R, Stuurman N. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science. 2007 Apr 20; 316(5823):417-21. PMID: 17412918; PMCID: PMC2837481.
    83. Roll-Mecak A, Vale R. Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? J Cell Biol. 2006 Dec 18; 175(6):849-51. PMID: 17178905; PMCID: PMC2064694.
    84. Tomishige M, Stuurman N, Vale R. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol. 2006 Oct; 13(10):887-94. PMID: 17013387.
      View in: PubMed
    85. Imanishi M, Endres NF, Gennerich A, Vale R. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. J Cell Biol. 2006 Sep 25; 174(7):931-7. PMID: 17000874; PMCID: PMC2064385.
    86. Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale R, Scholey JM. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006 Sep 25; 174(7):1035-45. PMID: 17000880; PMCID: PMC2064394.
    87. Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale R. Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Jul 28; 126(2):335-48. PMID: 16873064; PMCID: PMC2851639.
    88. Mahoney NM, Goshima G, Douglass AD, Vale R. Making microtubules and mitotic spindles in cells without functional centrosomes. Curr Biol. 2006 Mar 21; 16(6):564-9. PMID: 16546079.
      View in: PubMed
    89. Endres NF, Yoshioka C, Milligan RA, Vale R. A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature. 2006 Feb 16; 439(7078):875-8. PMID: 16382238; PMCID: PMC2851630.
    90. Jambhekar A, McDermott K, Sorber K, Shepard KA, Vale R, Takizawa PA, DeRisi JL. Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18005-10. PMID: 16326802; PMCID: PMC1298916.
    91. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale R. Length control of the metaphase spindle. Curr Biol. 2005 Nov 22; 15(22):1979-88. PMID: 16303556.
      View in: PubMed
    92. Goshima G, Nédélec F, Vale R. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J Cell Biol. 2005 Oct 24; 171(2):229-40. PMID: 16247025; PMCID: PMC2171195.
    93. Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale R, Portnoy DA. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13646-51. PMID: 16157870; PMCID: PMC1224656.
    94. Dean SO, Rogers SL, Stuurman N, Vale R, Spudich JA. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13473-8. PMID: 16174742; PMCID: PMC1200093.
    95. Dzhindzhev NS, Rogers SL, Vale R, Ohkura H. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J Cell Sci. 2005 Aug 15; 118(Pt 16):3781-90. PMID: 16105886.
      View in: PubMed
    96. Douglass AD, Vale R. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell. 2005 Jun 17; 121(6):937-50. PMID: 15960980; PMCID: PMC2851620.
    97. Goshima G, Vale R. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell. 2005 Aug; 16(8):3896-907. PMID: 15958489; PMCID: PMC1182325.
    98. Roll-Mecak A, Vale R. The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr Biol. 2005 Apr 12; 15(7):650-5. PMID: 15823537.
      View in: PubMed
    99. Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale R, Carter AP. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem. 2005 Jun 24; 280(25):23960-5. PMID: 15826937; PMCID: PMC1464088.
    100. Mennella V, Rogers GC, Rogers SL, Buster DW, Vale R, Sharp DJ. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat Cell Biol. 2005 Mar; 7(3):235-45. PMID: 15723056.
      View in: PubMed
    101. Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale R. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J Cell Biol. 2005 Feb 14; 168(4):587-98. PMID: 15699215; PMCID: PMC2171753.
    102. Rogers SL, Wiedemann U, Häcker U, Turck C, Vale R. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol. 2004 Oct 26; 14(20):1827-33. PMID: 15498490.
      View in: PubMed
    103. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale R, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
    104. Reck-Peterson SL, Vale R. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14305. PMID: 15693149; PMCID: PMC521152.
    105. Collins SR, Douglass A, Vale R, Weissman JS. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321. PMID: 15383837; PMCID: PMC517824.
    106. Klopfenstein DR, Vale R. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell. 2004 Aug; 15(8):3729-39. PMID: 15155810; PMCID: PMC491832.
    107. Dell KR, Vale R. A tribute to Shinya Inoue and innovation in light microscopy. J Cell Biol. 2004 Apr; 165(1):21-5. PMID: 15317131; PMCID: PMC2172095.
    108. Reck-Peterson SL, Vale R. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1491-5. PMID: 14755060; PMCID: PMC341754.
    109. Yildiz A, Tomishige M, Vale R, Selvin PR. Kinesin walks hand-over-hand. Science. 2004 Jan 30; 303(5658):676-8. PMID: 14684828.
      View in: PubMed
    110. Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale R, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22; 427(6972):364-70. PMID: 14681690.
      View in: PubMed
    111. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale R, Milligan RA. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J Cell Biol. 2003 Nov 24; 163(4):743-53. PMID: 14638858; PMCID: PMC2173678.
    112. Vale R. Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol. 2003 Nov 10; 163(3):445-50. PMID: 14610051; PMCID: PMC2173644.
    113. Shepard KA, Gerber AP, Jambhekar A, Takizawa PA, Brown PO, Herschlag D, DeRisi JL, Vale R. Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11429-34. PMID: 13679573; PMCID: PMC208774.
    114. Rogers SL, Wiedemann U, Stuurman N, Vale R. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol. 2003 Sep 15; 162(6):1079-88. PMID: 12975351; PMCID: PMC2172842.
    115. Goshima G, Vale R. The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol. 2003 Sep 15; 162(6):1003-16. PMID: 12975346; PMCID: PMC2172859.
    116. Yaffe MP, Stuurman N, Vale R. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. PMID: 12972644; PMCID: PMC208773.
    117. Rothenberg ME, Rogers SL, Vale R, Jan LY, Jan YN. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron. 2003 Aug 28; 39(5):779-91. PMID: 12948445.
      View in: PubMed
    118. Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale R, Kollman PA, Car R, Yount RG, Cooke R, Pate E. Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules. Science. 2003 May 2; 300(5620):798-801. PMID: 12730601.
      View in: PubMed
    119. Naber N, Rice S, Matuska M, Vale R, Cooke R, Pate E. EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J. 2003 May; 84(5):3190-6. PMID: 12719248; PMCID: PMC1302879.
    120. Rice S, Cui Y, Sindelar C, Naber N, Matuska M, Vale R, Cooke R. Thermodynamic properties of the kinesin neck-region docking to the catalytic core. Biophys J. 2003 Mar; 84(3):1844-54. PMID: 12609886; PMCID: PMC1302753.
    121. Vale R. The molecular motor toolbox for intracellular transport. Cell. 2003 Feb 21; 112(4):467-80. PMID: 12600311.
      View in: PubMed
    122. Tomishige M, Klopfenstein DR, Vale R. Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science. 2002 Sep 27; 297(5590):2263-7. PMID: 12351789.
      View in: PubMed
    123. Rogers SL, Rogers GC, Sharp DJ, Vale R. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J Cell Biol. 2002 Sep 2; 158(5):873-84. PMID: 12213835; PMCID: PMC2173155.
    124. Klopfenstein DR, Tomishige M, Stuurman N, Vale R. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 2002 May 3; 109(3):347-58. PMID: 12015984; PMCID: PMC2851634.
    125. Irie K, Tadauchi T, Takizawa PA, Vale R, Matsumoto K, Herskowitz I. The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J. 2002 Mar 1; 21(5):1158-67. PMID: 11867544; PMCID: PMC125877.
    126. Klopfenstein DR, Holleran EA, Vale R. Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum. J Muscle Res Cell Motil. 2002; 23(7-8):631-8. PMID: 12952062.
      View in: PubMed
    127. Tomishige M, Vale R. Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change. J Cell Biol. 2000 Nov 27; 151(5):1081-92. PMID: 11086009; PMCID: PMC2174365.
    128. Thorn KS, Ubersax JA, Vale R. Engineering the processive run length of the kinesin motor. J Cell Biol. 2000 Nov 27; 151(5):1093-100. PMID: 11086010; PMCID: PMC2174356.
    129. Wilhelm JE, Vale R, Hegde RS. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13132-7. PMID: 11087864; PMCID: PMC27190.
    130. Klopfenstein DR, Vale R, Rogers SL. Motor protein receptors: moonlighting on other jobs. Cell. 2000 Nov 10; 103(4):537-40. PMID: 11106727.
      View in: PubMed
    131. Prahlad V, Helfand BT, Langford GM, Vale R, Goldman RD. Fast transport of neurofilament protein along microtubules in squid axoplasm. J Cell Sci. 2000 Nov; 113 ( Pt 22):3939-46. PMID: 11058081.
      View in: PubMed
    132. Takizawa PA, DeRisi JL, Wilhelm JE, Vale R. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science. 2000 Oct 13; 290(5490):341-4. PMID: 11030653.
      View in: PubMed
    133. Vale R. AAA proteins. Lords of the ring. J Cell Biol. 2000 Jul 10; 150(1):F13-9. PMID: 10893253; PMCID: PMC2185557.
    134. Khan S, Pierce D, Vale R. Interactions of the chemotaxis signal protein CheY with bacterial flagellar motors visualized by evanescent wave microscopy. Curr Biol. 2000 Jul 27-Aug 10; 10(15):927-30. PMID: 10959841.
      View in: PubMed
    135. Shimizu T, Thorn KS, Ruby A, Vale R. ATPase kinetic characterization and single molecule behavior of mutant human kinesin motors defective in microtubule-based motility. Biochemistry. 2000 May 9; 39(18):5265-73. PMID: 10819995.
      View in: PubMed
    136. Takizawa PA, Vale R. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Proc Natl Acad Sci U S A. 2000 May 9; 97(10):5273-8. PMID: 10792032; PMCID: PMC25818.
    137. Vale R, Case R, Sablin E, Hart C, Fletterick R. Searching for kinesin's mechanical amplifier. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):449-57. PMID: 10836498; PMCID: PMC1692751.
    138. Vale R, Milligan RA. The way things move: looking under the hood of molecular motor proteins. Science. 2000 Apr 7; 288(5463):88-95. PMID: 10753125.
      View in: PubMed
    139. Hopkins SC, Vale R, Kuntz ID. Inhibitors of kinesin activity from structure-based computer screening. Biochemistry. 2000 Mar 14; 39(10):2805-14. PMID: 10704233.
      View in: PubMed
    140. Case RB, Rice S, Hart CL, Ly B, Vale R. Role of the kinesin neck linker and catalytic core in microtubule-based motility. Curr Biol. 2000 Feb 10; 10(3):157-60. PMID: 10679326.
      View in: PubMed
    141. Wilhelm JE, Mansfield J, Hom-Booher N, Wang S, Turck CW, Hazelrigg T, Vale R. Isolation of a ribonucleoprotein complex involved in mRNA localization in Drosophila oocytes. J Cell Biol. 2000 Feb 7; 148(3):427-40. PMID: 10662770; PMCID: PMC2174796.
    142. Thorn KS, Naber N, Matuska M, Vale R, Cooke R. A novel method of affinity-purifying proteins using a bis-arsenical fluorescein. Protein Sci. 2000 Feb; 9(2):213-7. PMID: 10716173; PMCID: PMC2144555.
    143. Govindan B, Vale R. Characterization of a microtubule assembly inhibitor from Xenopus oocytes. Cell Motil Cytoskeleton. 2000 Jan; 45(1):51-7. PMID: 10618166.
      View in: PubMed
    144. Dell KR, Turck CW, Vale R. Mitotic phosphorylation of the dynein light intermediate chain is mediated by cdc2 kinase. Traffic. 2000 Jan; 1(1):38-44. PMID: 11208058.
      View in: PubMed
    145. Rice S, Lin AW, Safer D, Hart CL, Naber N, Carragher BO, Cain SM, Pechatnikova E, Wilson-Kubalek EM, Whittaker M, Pate E, Cooke R, Taylor EW, Milligan RA, Vale R. A structural change in the kinesin motor protein that drives motility. Nature. 1999 Dec 16; 402(6763):778-84. PMID: 10617199.
      View in: PubMed
    146. Silva MM, Goreti M, Vale R, Caramão EB. Slurry sampling graphite furnace atomic absorption spectrometry: determination of trace metals in mineral coal. Talanta. 1999 Dec 6; 50(5):1035-43. PMID: 18967798.
      View in: PubMed
    147. Vale R. Millennial musings on molecular motors. Trends Cell Biol. 1999 Dec; 9(12):M38-42. PMID: 10611679.
      View in: PubMed
    148. Pollock N, de Hostos EL, Turck CW, Vale R. Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium. J Cell Biol. 1999 Nov 1; 147(3):493-506. PMID: 10545495; PMCID: PMC2151178.
    149. Hartman JJ, Vale R. Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin. Science. 1999 Oct 22; 286(5440):782-5. PMID: 10531065.
      View in: PubMed
    150. Friedman DS, Vale R. Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain. Nat Cell Biol. 1999 Sep; 1(5):293-7. PMID: 10559942.
      View in: PubMed
    151. Pierce DW, Hom-Booher N, Otsuka AJ, Vale R. Single-molecule behavior of monomeric and heteromeric kinesins. Biochemistry. 1999 Apr 27; 38(17):5412-21. PMID: 10220328.
      View in: PubMed
    152. Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale R, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999 Jan 11; 144(1):125-38. PMID: 9885249; PMCID: PMC2148119.
    153. Pierce DW, Vale R. Single-molecule fluorescence detection of green fluorescence protein and application to single-protein dynamics. Methods Cell Biol. 1999; 58:49-73. PMID: 9891374.
      View in: PubMed
    154. Kull FJ, Vale R, Fletterick RJ. The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil. 1998 Nov; 19(8):877-86. PMID: 10047987.
      View in: PubMed
    155. Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale R, Fletterick RJ. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 1998 Oct 22; 395(6704):813-6. PMID: 9796817.
      View in: PubMed
    156. Prahlad V, Yoon M, Moir RD, Vale R, Goldman RD. Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks. J Cell Biol. 1998 Oct 5; 143(1):159-70. PMID: 9763428; PMCID: PMC2132817.
    157. de Hostos EL, McCaffrey G, Sucgang R, Pierce DW, Vale R. A developmentally regulated kinesin-related motor protein from Dictyostelium discoideum. Mol Biol Cell. 1998 Aug; 9(8):2093-106. PMID: 9693369; PMCID: PMC25463.
    158. Wells SE, Hillner PE, Vale R, Sachs AB. Circularization of mRNA by eukaryotic translation initiation factors. Mol Cell. 1998 Jul; 2(1):135-40. PMID: 9702200.
      View in: PubMed
    159. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale R, McNally FJ. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell. 1998 Apr 17; 93(2):277-87. PMID: 9568719.
      View in: PubMed
    160. Lohman TM, Thorn K, Vale R. Staying on track: common features of DNA helicases and microtubule motors. Cell. 1998 Apr 3; 93(1):9-12. PMID: 9546385.
      View in: PubMed
    161. Romberg L, Pierce DW, Vale R. Role of the kinesin neck region in processive microtubule-based motility. J Cell Biol. 1998 Mar 23; 140(6):1407-16. PMID: 9508773; PMCID: PMC2132664.
    162. Pollock N, Koonce MP, de Hostos EL, Vale R. In vitro microtubule-based organelle transport in wild-type Dictyostelium and cells overexpressing a truncated dynein heavy chain. Cell Motil Cytoskeleton. 1998; 40(3):304-14. PMID: 9678672.
      View in: PubMed
    163. Pierce DW, Vale R. Assaying processive movement of kinesin by fluorescence microscopy. Methods Enzymol. 1998; 298:154-71. PMID: 9751879.
      View in: PubMed
    164. Funatsu T, Harada Y, Higuchi H, Tokunaga M, Saito K, Ishii Y, Vale R, Yanagida T. Imaging and nano-manipulation of single biomolecules. Biophys Chem. 1997 Oct; 68(1-3):63-72. PMID: 9468610.
      View in: PubMed
    165. Case RB, Pierce DW, Hom-Booher N, Hart CL, Vale R. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell. 1997 Sep 5; 90(5):959-66. PMID: 9298907.
      View in: PubMed
    166. Takizawa PA, Sil A, Swedlow JR, Herskowitz I, Vale R. Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature. 1997 Sep 4; 389(6646):90-3. PMID: 9288973.
      View in: PubMed
    167. Coppin CM, Pierce DW, Hsu L, Vale R. The load dependence of kinesin's mechanical cycle. Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16):8539-44. PMID: 9238012; PMCID: PMC23000.
    168. Woehlke G, Ruby AK, Hart CL, Ly B, Hom-Booher N, Vale R. Microtubule interaction site of the kinesin motor. Cell. 1997 Jul 25; 90(2):207-16. PMID: 9244295.
      View in: PubMed
    169. Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale R, Milligan RA. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 1997 Jul 25; 90(2):217-24. PMID: 9244296.
      View in: PubMed
    170. Pierce DW, Hom-Booher N, Vale R. Imaging individual green fluorescent proteins. Nature. 1997 Jul 24; 388(6640):338. PMID: 9237750.
      View in: PubMed
    171. Tripet B, Vale R, Hodges RS. Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides. Implications for motor activity. J Biol Chem. 1997 Apr 4; 272(14):8946-56. PMID: 9083016.
      View in: PubMed
    172. Vale R, Fletterick RJ. The design plan of kinesin motors. Annu Rev Cell Dev Biol. 1997; 13:745-77. PMID: 9442886.
      View in: PubMed
    173. Vale R. Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J Cell Biol. 1996 Oct; 135(2):291-302. PMID: 8896589; PMCID: PMC2121043.
    174. Niclas J, Allan VJ, Vale R. Cell cycle regulation of dynein association with membranes modulates microtubule-based organelle transport. J Cell Biol. 1996 May; 133(3):585-93. PMID: 8636233; PMCID: PMC2120815.
    175. Sablin EP, Kull FJ, Cooke R, Vale R, Fletterick RJ. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 1996 Apr 11; 380(6574):555-9. PMID: 8606780.
      View in: PubMed
    176. Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale R. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996 Apr 11; 380(6574):550-5. PMID: 8606779; PMCID: PMC2851642.
    177. Vale R, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T. Direct observation of single kinesin molecules moving along microtubules. Nature. 1996 Apr 4; 380(6573):451-3. PMID: 8602245; PMCID: PMC2852185.
    178. Coppin CM, Finer JT, Spudich JA, Vale R. Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy. Proc Natl Acad Sci U S A. 1996 Mar 5; 93(5):1913-7. PMID: 8700858; PMCID: PMC39882.
    179. McNally FJ, Okawa K, Iwamatsu A, Vale R. Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. J Cell Sci. 1996 Mar; 109 ( Pt 3):561-7. PMID: 8907702.
      View in: PubMed
    180. Vignali G, Niclas J, Sprocati MT, Vale R, Sirtori C, Navone F. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Eur J Neurosci. 1996 Mar; 8(3):536-44. PMID: 8963445.
      View in: PubMed
    181. Wilhelm JE, Vale R. A one-hybrid system for detecting RNA-protein interactions. Genes Cells. 1996 Mar; 1(3):317-23. PMID: 9133665.
      View in: PubMed
    182. Fowler VM, Vale R. Cytoskeleton. Curr Opin Cell Biol. 1996 Feb; 8(1):1-3. PMID: 8791412.
      View in: PubMed
    183. Shimizu T, Sablin E, Vale R, Fletterick R, Pechatnikova E, Taylor EW. Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain. Biochemistry. 1995 Oct 10; 34(40):13259-66. PMID: 7548090.
      View in: PubMed
    184. Hoenger A, Sablin EP, Vale R, Fletterick RJ, Milligan RA. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 1995 Jul 20; 376(6537):271-4. PMID: 7617040.
      View in: PubMed
    185. Coppin CM, Finer JT, Spudich JA, Vale R. Measurement of the isometric force exerted by a single kinesin molecule. Biophys J. 1995 Apr; 68(4 Suppl):242S-244S. PMID: 7787084; PMCID: PMC1281934.
    186. Shimizu T, Toyoshima YY, Edamatsu M, Vale R. Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein. Biochemistry. 1995 Feb 7; 34(5):1575-82. PMID: 7849016.
      View in: PubMed
    187. Vale R, Coppin CM, Malik F, Kull FJ, Milligan RA. Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules. J Biol Chem. 1994 Sep 23; 269(38):23769-75. PMID: 7916345.
      View in: PubMed
    188. Vale R. Getting a grip on myosin. Cell. 1994 Sep 9; 78(5):733-7. PMID: 8087841.
      View in: PubMed
    189. Allan V, Vale R. Movement of membrane tubules along microtubules in vitro: evidence for specialised sites of motor attachment. J Cell Sci. 1994 Jul; 107 ( Pt 7):1885-97. PMID: 7983155.
      View in: PubMed
    190. Malik F, Brillinger D, Vale R. High-resolution tracking of microtubule motility driven by a single kinesin motor. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4584-8. PMID: 8183952; PMCID: PMC43830.
    191. Niclas J, Navone F, Hom-Booher N, Vale R. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 1994 May; 12(5):1059-72. PMID: 7514426.
      View in: PubMed
    192. McNally FJ, Vale R. Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell. 1993 Nov 5; 75(3):419-29. PMID: 8221885.
      View in: PubMed
    193. Wilhelm JE, Vale R. RNA on the move: the mRNA localization pathway. J Cell Biol. 1993 Oct; 123(2):269-74. PMID: 8408211; PMCID: PMC2119838.
    194. Vale R. Measuring single protein motors at work. Science. 1993 Apr 9; 260(5105):169-70. PMID: 8469971.
      View in: PubMed
    195. Romberg L, Vale R. Chemomechanical cycle of kinesin differs from that of myosin. Nature. 1993 Jan 14; 361(6408):168-70. PMID: 8421522.
      View in: PubMed
    196. Shimizu T, Toyoshima YY, Vale R. Use of ATP analogs in motor assays. Methods Cell Biol. 1993; 39:167-77. PMID: 8246796.
      View in: PubMed
    197. Vale R, Malik F, Brown D. Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. J Cell Biol. 1992 Dec; 119(6):1589-96. PMID: 1469050; PMCID: PMC2289742.
    198. Goldstein LS, Vale R. Cell biology. New cytoskeletal liaisons. Nature. 1992 Sep 17; 359(6392):193-4. PMID: 1388245.
      View in: PubMed
    199. Vale R. Microtubule motors: many new models off the assembly line. Trends Biochem Sci. 1992 Aug; 17(8):300-4. PMID: 1412704.
      View in: PubMed
    200. Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale R. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. J Cell Biol. 1992 Jun; 117(6):1263-75. PMID: 1607388; PMCID: PMC2289507.
    201. Ferreira A, Niclas J, Vale R, Banker G, Kosik KS. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol. 1992 May; 117(3):595-606. PMID: 1533397; PMCID: PMC2289440.
    202. Goldstein LS, Vale R. Motor proteins. A brave new world for dynein. Nature. 1991 Aug 15; 352(6336):569-70. PMID: 1830924.
      View in: PubMed
    203. Allan VJ, Vale R. Cell cycle control of microtubule-based membrane transport and tubule formation in vitro. J Cell Biol. 1991 Apr; 113(2):347-59. PMID: 2010466; PMCID: PMC2288932.
    204. Schliwa M, Shimizu T, Vale R, Euteneuer U. Nucleotide specificities of anterograde and retrograde organelle transport in Reticulomyxa are indistinguishable. J Cell Biol. 1991 Mar; 112(6):1199-203. PMID: 1825662; PMCID: PMC2288898.
    205. Shimizu T, Furusawa K, Ohashi S, Toyoshima YY, Okuno M, Malik F, Vale R. Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. J Cell Biol. 1991 Mar; 112(6):1189-97. PMID: 1825661; PMCID: PMC2288895.
    206. Vale R. Severing of stable microtubules by a mitotically activated protein in Xenopus egg extracts. Cell. 1991 Feb 22; 64(4):827-39. PMID: 1671762.
      View in: PubMed
    207. Malik F, Vale R. Cell biology. A new direction for kinesin. Nature. 1990 Oct 25; 347(6295):713-4. PMID: 2146508.
      View in: PubMed
    208. Vale R, Goldstein LS. One motor, many tails: an expanding repertoire of force-generating enzymes. Cell. 1990 Mar 23; 60(6):883-5. PMID: 2138513.
      View in: PubMed
    209. Vale R. Microtubule-based motor proteins. Curr Opin Cell Biol. 1990 Feb; 2(1):15-22. PMID: 2139334.
      View in: PubMed
    210. Vale R, Oosawa F. Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet? Adv Biophys. 1990; 26:97-134. PMID: 2150583.
      View in: PubMed
    211. Vale R, Soll DR, Gibbons IR. One-dimensional diffusion of microtubules bound to flagellar dynein. Cell. 1989 Dec 1; 59(5):915-25. PMID: 2531633.
      View in: PubMed
    212. Howard J, Hudspeth AJ, Vale R. Movement of microtubules by single kinesin molecules. Nature. 1989 Nov 9; 342(6246):154-8. PMID: 2530455.
      View in: PubMed
    213. McCaffrey G, Vale R. Identification of a kinesin-like microtubule-based motor protein in Dictyostelium discoideum. EMBO J. 1989 Nov; 8(11):3229-34. PMID: 2531077; PMCID: PMC401445.
    214. Vale R, Toyoshima YY. Microtubule translocation properties of intact and proteolytically digested dyneins from Tetrahymena cilia. J Cell Biol. 1989 Jun; 108(6):2327-34. PMID: 2525562; PMCID: PMC2115603.
    215. Vale R, Hotani H. Formation of membrane networks in vitro by kinesin-driven microtubule movement. J Cell Biol. 1988 Dec; 107(6 Pt 1):2233-41. PMID: 3143735; PMCID: PMC2115687.
    216. Vale R, Toyoshima YY. Rotation and translocation of microtubules in vitro induced by dyneins from Tetrahymena cilia. Cell. 1988 Feb 12; 52(3):459-69. PMID: 2964278.
      View in: PubMed
    217. Porter ME, Scholey JM, Stemple DL, Vigers GP, Vale R, Sheetz MP, McIntosh JR. Characterization of the microtubule movement produced by sea urchin egg kinesin. J Biol Chem. 1987 Feb 25; 262(6):2794-802. PMID: 3102475.
      View in: PubMed
    218. Sheetz MP, Vale R, Schnapp B, Schroer T, Reese T. Movements of vesicles on microtubules. Ann N Y Acad Sci. 1987; 493:409-16. PMID: 3109300.
      View in: PubMed
    219. Vale R. Intracellular transport using microtubule-based motors. Annu Rev Cell Biol. 1987; 3:347-78. PMID: 3120763.
      View in: PubMed
    220. Sheetz MP, Vale R, Schnapp B, Schroer T, Reese T. Vesicle movements and microtubule-based motors. J Cell Sci Suppl. 1986; 5:181-8. PMID: 2443518.
      View in: PubMed
    221. Schnapp BJ, Vale R, Sheetz MP, Reese TS. Microtubules and the mechanism of directed organelle movement. Ann N Y Acad Sci. 1986; 466:909-18. PMID: 2425684.
      View in: PubMed
    222. Vale R, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec; 43(3 Pt 2):623-32. PMID: 2416467.
      View in: PubMed
    223. Vale R, Reese TS, Sheetz MP. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 1985 Aug; 42(1):39-50. PMID: 3926325; PMCID: PMC2851632.
    224. Vale R, Schnapp BJ, Reese TS, Sheetz MP. Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon. Cell. 1985 Mar; 40(3):559-69. PMID: 2578887.
      View in: PubMed
    225. Schnapp BJ, Vale R, Sheetz MP, Reese TS. Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell. 1985 Feb; 40(2):455-62. PMID: 2578325.
      View in: PubMed
    226. Vale R, Schnapp BJ, Reese TS, Sheetz MP. Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell. 1985 Feb; 40(2):449-54. PMID: 2578324.
      View in: PubMed
    227. Vale R, Hosang M, Shooter EM. Sialic acid residues on NGF receptors on PC12 cells. Dev Neurosci. 1985; 7(1):55-64. PMID: 2992906.
      View in: PubMed
    228. Vale R, Shooter EM. Assaying binding of nerve growth factor to cell surface receptors. Methods Enzymol. 1985; 109:21-39. PMID: 2985916.
      View in: PubMed
    229. Vale R, Szent-Gyorgyi AG, Sheetz MP. Movement of scallop myosin on Nitella actin filaments: regulation by calcium. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6775-8. PMID: 6238334; PMCID: PMC392014.
    230. Vale R, Peterson SW, Matiuck NV, Fox CF. Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. J Cell Biol. 1984 Mar; 98(3):1129-32. PMID: 6607925; PMCID: PMC2113147.
    231. Vale R, Shooter EM. Conversion of nerve growth factor-receptor complexes to a slowly dissociating, Triton X-100 insoluble state by anti nerve growth factor antibodies. Biochemistry. 1983 Oct 11; 22(21):5022-8. PMID: 6315057.
      View in: PubMed
    232. Vale R, Shooter EM. Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin. J Cell Biol. 1982 Sep; 94(3):710-7. PMID: 6290502; PMCID: PMC2112231.
    Ron's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP