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Ron Vale, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
Phone415-476-6380
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    Other Positions
    TitleHoward Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    2014Institute of Medicine Member
    2012Albert Lasker Basic Medical Research Award

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Microtubule-Based Motility
    NIH R35GM118106Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Creating an online resource center for training and professional development in the biomedical sciences
    NIH R25GM116704Sep 25, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Structure and mechanism of the dynein motor
    NIH R01GM097312Apr 1, 2011 - Mar 31, 2019
    Role: Principal Investigator
    Open Source Microscopy Software
    NIH R01EB007187Apr 1, 2007 - Aug 31, 2015
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13GM085967Sep 20, 2004 - May 31, 2018
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13DK069546Sep 20, 2004 - Jul 31, 2007
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    PROTEIN MODULATORS OF MICROTUBULE DYNAMICS
    NIH R01GM049752Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Microtubule Complexes Involved in Intracelluar Transport
    NIH R37GM038499Feb 1, 1988 - Aug 31, 2016
    Role: Principal Investigator
    Macromoleclar Complexes Involved in Cellular Transport
    NIH R01GM038499Feb 1, 1988 - Aug 31, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale R. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 Jun 13; 7. PMID: 29897330.
      View in: PubMed
    2. Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale R. Chimeric antigen receptors that trigger phagocytosis. Elife. 2018 Jun 04; 7. PMID: 29862966.
      View in: PubMed
    3. Reck-Peterson SL, Redwine WB, Vale R, Carter AP. Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 May 08. PMID: 29740130.
      View in: PubMed
    4. Reck-Peterson SL, Redwine WB, Vale R, Carter AP. The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 Apr 16. PMID: 29662141.
      View in: PubMed
    5. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale R. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44):E9338-E9345. PMID: 29042512.
      View in: PubMed
    6. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106. PMID: 28912235.
      View in: PubMed
    7. Huynh W, Vale R. Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin. J Cell Biol. 2017 10 02; 216(10):3051-3060. PMID: 28883039.
      View in: PubMed
    8. Jain A, Vale R. RNA phase transitions in repeat expansion disorders. Nature. 2017 06 08; 546(7657):243-247. PMID: 28562589.
      View in: PubMed
    9. Bourne PE, Polka JK, Vale R, Kiley R. Ten simple rules to consider regarding preprint submission. PLoS Comput Biol. 2017 May; 13(5):e1005473. PMID: 28472041.
      View in: PubMed
    10. Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale R. Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. Cell. 2017 Apr 06; 169(2):273-285.e17. PMID: 28388411.
      View in: PubMed
    11. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale R. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23; 169(1):108-119.e20. PMID: 28340336.
      View in: PubMed
    12. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale R. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. PMID: 28280247.
      View in: PubMed
    13. Su X, Ditlev JA, Rosen MK, Vale R. Reconstitution of TCR Signaling Using Supported Lipid Bilayers. Methods Mol Biol. 2017; 1584:65-76. PMID: 28255696.
      View in: PubMed
    14. Carbone CB, Vale R, Stuurman N. An acquisition and analysis pipeline for scanning angle interference microscopy. Nat Methods. 2016 Oct 31; 13(11):897-898. PMID: 27798596.
      View in: PubMed
    15. Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2016 09 29; 13(10):807-809. PMID: 27684577.
      View in: PubMed
    16. Schroeder CM, Vale R. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J Cell Biol. 2016 08 01; 214(3):309-18. PMID: 27482052.
      View in: PubMed
    17. Stuurman N, Vale R. Impact of New Camera Technologies on Discoveries in Cell Biology. Biol Bull. 2016 Aug; 231(1):5-13. PMID: 27638691.
      View in: PubMed
    18. Vale R, Hyman AA. Priority of discovery in the life sciences. Elife. 2016 06 16; 5. PMID: 27310529; PMCID: PMC4911212.
    19. Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale R, VijayRaghavan K, Wolberger C. SCIENTIFIC COMMUNITY. Preprints for the life sciences. Science. 2016 May 20; 352(6288):899-901. PMID: 27199406.
      View in: PubMed
    20. Yan X, Hoek TA, Vale R, Tanenbaum ME. Dynamics of Translation of Single mRNA Molecules In Vivo. Cell. 2016 May 05; 165(4):976-89. PMID: 27153498; PMCID: PMC4889334.
    21. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale R, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. PMID: 27112495; PMCID: PMC4860041 [Available on 05/04/17].
    22. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale R. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844; PMCID: PMC4892427 [Available on 10/29/16].
    23. McKenney RJ, Huynh W, Vale R, Sirajuddin M. Tyrosination of a-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 06 01; 35(11):1175-85. PMID: 26968983; PMCID: PMC4888239 [Available on 06/01/17].
    24. Bhabha G, Johnson GT, Schroeder CM, Vale R. How Dynein Moves Along Microtubules. Trends Biochem Sci. 2016 Jan; 41(1):94-105. PMID: 26678005.
      View in: PubMed
    25. Vale R. Accelerating scientific publication in biology. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):13439-46. PMID: 26508643; PMCID: PMC4640799.
    26. Dell KR, Vale R. iBioChina and iBiology: spreading scientific knowledge together. Sci China Life Sci. 2015 Nov; 58(11):1180-2. PMID: 26423567.
      View in: PubMed
    27. Yildiz A, Vale R. Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep 01; 2015(9):pdb.prot086355. PMID: 26330626.
      View in: PubMed
    28. Petry S, Vale R. Microtubule nucleation at the centrosome and beyond. Nat Cell Biol. 2015 Sep; 17(9):1089-93. PMID: 26316453.
      View in: PubMed
    29. Yildiz A, Vale R. Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep 01; 2015(9):pdb.top086348. PMID: 26330632.
      View in: PubMed
    30. Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale R. Regulation of mRNA translation during mitosis. Elife. 2015 Aug 25; 4. PMID: 26305499; PMCID: PMC4548207.
    31. Jonsson E, Yamada M, Vale R, Goshima G. Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants. Nat Plants. 2015 Jul; 1(7). PMID: 26322239.
      View in: PubMed
    32. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale R, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35. PMID: 26125038; PMCID: PMC4479523.
    33. Ham H, Huynh W, Schoon RA, Vale R, Billadeau DD. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015 Apr 15; 194(8):3984-96. PMID: 25762780; PMCID: PMC4390494.
    34. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale R. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 06; 159(4):857-68. PMID: 25417161; PMCID: PMC4269335.
    35. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale R. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. PMID: 25307933; PMCID: PMC4252608.
    36. Schroeder CM, Ostrem JM, Hertz NT, Vale R. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. Elife. 2014 Oct 01; 3:e03351. PMID: 25272277; PMCID: PMC4359372.
    37. Ribeiro SA, D'Ambrosio MV, Vale R. Induction of focal adhesions and motility in Drosophila S2 cells. Mol Biol Cell. 2014 Dec 01; 25(24):3861-9. PMID: 25273555; PMCID: PMC4244196.
    38. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale R. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. PMID: 25035494; PMCID: PMC4224444.
    39. Hendershott MC, Vale R. Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5860-5. PMID: 24706919; PMCID: PMC4000804.
    40. Sirajuddin M, Rice LM, Vale R. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat Cell Biol. 2014 Apr; 16(4):335-44. PMID: 24633327; PMCID: PMC4117587.
    41. Hui E, Vale R. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. PMID: 24463463; PMCID: PMC4062301.
    42. Toret CP, D'Ambrosio MV, Vale R, Simon MA, Nelson WJ. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014 Jan 20; 204(2):265-79. PMID: 24446484; PMCID: PMC3897182.
    43. Vale R. Preface: the role of reconstitution in cytoskeleton research. Methods Enzymol. 2014; 540:xix-xxiii. PMID: 24630122.
      View in: PubMed
    44. Edelstein AD, Tsuchida MA, Amodaj N, Pinkard H, Vale R, Stuurman N. Advanced methods of microscope control using µManager software. J Biol Methods. 2014; 1(2). PMID: 25606571.
      View in: PubMed
    45. Moutinho-Pereira S, Stuurman N, Afonso O, Hornsveld M, Aguiar P, Goshima G, Vale R, Maiato H. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19808-13. PMID: 24255106; PMCID: PMC3856817.
    46. Doyle KM, Vale R. Creating opportunities for science PhDs to pursue careers in high school education. Mol Biol Cell. 2013 Nov; 24(21):3292-6. PMID: 24174464; PMCID: PMC3814146.
    47. Tanenbaum ME, Vale R, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013 Sep 03; 2:e00943. PMID: 24015359; PMCID: PMC3762337.
    48. Vale R. The value of asking questions. Mol Biol Cell. 2013 Mar; 24(6):680-2. PMID: 23486404; PMCID: PMC3596240.
    49. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale R. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77. PMID: 23415226; PMCID: PMC3680348.
    50. Vale R, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3. PMID: 23258877.
      View in: PubMed
    51. Vale R. How lucky can one be? A perspective from a young scientist at the right place at the right time. Nat Med. 2012 Oct; 18(10):1486-8. PMID: 23042358.
      View in: PubMed
    52. Vale R. Evaluating how we evaluate. Mol Biol Cell. 2012 Sep; 23(17):3285-9. PMID: 22936699; PMCID: PMC3431935.
    53. James JR, Vale R. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature. 2012 Jul 05; 487(7405):64-9. PMID: 22763440; PMCID: PMC3393772.
    54. Zou W, Wang X, Vale R, Ou G. Autophagy genes promote apoptotic cell corpse clearance. Autophagy. 2012 Aug; 8(8):1267-8. PMID: 22653037.
      View in: PubMed
    55. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X, Vale R, Ou G. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012 Apr 02; 197(1):27-35. PMID: 22451698; PMCID: PMC3317810.
    56. Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale R, Jülicher F, Reck-Peterson SL, Dogterom M. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Feb 03; 148(3):502-14. PMID: 22304918; PMCID: PMC3292199.
    57. Petry S, Vale R. A new cap for kinetochore fibre minus ends. Nat Cell Biol. 2011 Nov 13; 13(12):1389-91. PMID: 22081093; PMCID: PMC3532025.
    58. Cho C, Vale R. The mechanism of dynein motility: insight from crystal structures of the motor domain. Biochim Biophys Acta. 2012 Jan; 1823(1):182-91. PMID: 22062687; PMCID: PMC3249483.
    59. Petry S, Pugieux C, Nédélec FJ, Vale R. Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14473-8. PMID: 21844347; PMCID: PMC3167534.
    60. Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale R, Prasad BC, Clark SG, Garriga G. The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr Biol. 2011 Jun 07; 21(11):948-54. PMID: 21596567; PMCID: PMC3109113.
    61. Carter AP, Cho C, Jin L, Vale R. Crystal structure of the dynein motor domain. Science. 2011 Mar 04; 331(6021):1159-65. PMID: 21330489; PMCID: PMC3169322.
    62. Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale R. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 2011 Mar 04; 286(9):7457-67. PMID: 21169635; PMCID: PMC3045001.
    63. Yudushkin IA, Vale R. Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3? in the endosomal compartment. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22128-33. PMID: 21135224; PMCID: PMC3009781.
    64. D'Ambrosio MV, Vale R. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Biol. 2010 Nov 01; 191(3):471-8. PMID: 21041442; PMCID: PMC3003316.
    65. Goodwin SS, Vale R. Patronin regulates the microtubule network by protecting microtubule minus ends. Cell. 2010 Oct 15; 143(2):263-74. PMID: 20946984; PMCID: PMC3008421.
    66. Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N. Computer control of microscopes using µManager. Curr Protoc Mol Biol. 2010 Oct; Chapter 14:Unit14.20. PMID: 20890901; PMCID: PMC3065365.
    67. Ou G, Stuurman N, D'Ambrosio M, Vale R. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010 Oct 29; 330(6004):677-80. PMID: 20929735; PMCID: PMC3032534.
    68. Tole S, Vale R. Young leaders for biology in India. Science. 2010 Sep 17; 329(5998):1441. PMID: 20847237.
      View in: PubMed
    69. Yu CH, Wu HJ, Kaizuka Y, Vale R, Groves JT. Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS One. 2010 Jul 29; 5(7):e11878. PMID: 20686692; PMCID: PMC2912367.
    70. Uehara R, Goshima G, Mabuchi I, Vale R, Spudich JA, Griffis ER. Determinants of myosin II cortical localization during cytokinesis. Curr Biol. 2010 Jun 22; 20(12):1080-5. PMID: 20541410; PMCID: PMC2930192.
    71. Carter AP, Vale R. Communication between the AAA+ ring and microtubule-binding domain of dynein. Biochem Cell Biol. 2010 Feb; 88(1):15-21. PMID: 20130675; PMCID: PMC2894566.
    72. Vale R. It's a wonderful life: a career as an academic scientist. Mol Biol Cell. 2010 Jan 01; 21(1):11-4. PMID: 20048258; PMCID: PMC2801704.
    73. Kardon JR, Vale R. Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol. 2009 Dec; 10(12):854-65. PMID: 19935668; PMCID: PMC3394690.
    74. Vale R, Spudich JA, Griffis ER. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol. 2009 Sep 07; 186(5):727-38. PMID: 19720876; PMCID: PMC2742194.
    75. DePristo MA, Chang L, Vale R, Khan SM, Lipkow K. Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy. Prog Biophys Mol Biol. 2009 Sep-Oct; 100(1-3):25-32. PMID: 19628003; PMCID: PMC2805826.
    76. Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale R. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol. 2009 May 04; 185(3):521-34. PMID: 19398758; PMCID: PMC2700390.
    77. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale R, Obuse C, Goshima G. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6998-7003. PMID: 19369198.
      View in: PubMed
    78. Ou G, Vale R. Molecular signatures of cell migration in C. elegans Q neuroblasts. J Cell Biol. 2009 Apr 06; 185(1):77-85. PMID: 19349580; PMCID: PMC2700521.
    79. Kardon JR, Reck-Peterson SL, Vale R. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5669-74. PMID: 19293377; PMCID: PMC2657088.
    80. Vale R, Dell K. The biological sciences in India: aiming high for the future. J Cell Biol. 2009 Feb 09; 184(3):342-53. PMID: 19204144; PMCID: PMC2646550.
    81. Gennerich A, Vale R. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb; 21(1):59-67. PMID: 19179063; PMCID: PMC2668149.
    82. Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale R, Gibbons IR. Structure and functional role of dynein's microtubule-binding domain. Science. 2008 Dec 12; 322(5908):1691-5. PMID: 19074350; PMCID: PMC2663340.
    83. Vale R. Microscopes for fluorimeters: the era of single molecule measurements. Cell. 2008 Nov 28; 135(5):779-85. PMID: 19041739; PMCID: PMC2762818.
    84. Yildiz A, Tomishige M, Gennerich A, Vale R. Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell. 2008 Sep 19; 134(6):1030-41. PMID: 18805095; PMCID: PMC2613771.
    85. Cho C, Reck-Peterson SL, Vale R. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem. 2008 Sep 19; 283(38):25839-45. PMID: 18650442; PMCID: PMC2533788.
    86. Goshima G, Mayer M, Zhang N, Stuurman N, Vale R. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol. 2008 May 05; 181(3):421-9. PMID: 18443220; PMCID: PMC2364697.
    87. Trammell MA, Mahoney NM, Agard DA, Vale R. Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci. 2008 Apr 15; 121(Pt 8):1284-92. PMID: 18388316; PMCID: PMC2851640.
    88. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale R, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709; PMCID: PMC2734507.
    89. Roll-Mecak A, Vale R. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature. 2008 Jan 17; 451(7176):363-7. PMID: 18202664; PMCID: PMC2882799.
    90. Douglass AD, Vale R. Single-molecule imaging of fluorescent proteins. Methods Cell Biol. 2008; 85:113-25. PMID: 18155461.
      View in: PubMed
    91. Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale R. Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20296-301. PMID: 18077330; PMCID: PMC2154425.
    92. Gennerich A, Carter AP, Reck-Peterson SL, Vale R. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Nov 30; 131(5):952-65. PMID: 18045537; PMCID: PMC2851641.
    93. Mori T, Vale R, Tomishige M. How kinesin waits between steps. Nature. 2007 Nov 29; 450(7170):750-4. PMID: 18004302.
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    94. Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. J Biol Chem. 2007 Nov 30; 282(48):34748-57. PMID: 17911103.
      View in: PubMed
    95. Slep KC, Vale R. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Mol Cell. 2007 Sep 21; 27(6):976-91. PMID: 17889670; PMCID: PMC2052927.
    96. Griffis ER, Stuurman N, Vale R. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007 Jun 18; 177(6):1005-15. PMID: 17576797; PMCID: PMC2064361.
    97. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale R, Stuurman N. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science. 2007 Apr 20; 316(5823):417-21. PMID: 17412918; PMCID: PMC2837481.
    98. Roll-Mecak A, Vale R. Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? J Cell Biol. 2006 Dec 18; 175(6):849-51. PMID: 17178905; PMCID: PMC2064694.
    99. Tomishige M, Stuurman N, Vale R. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol. 2006 Oct; 13(10):887-94. PMID: 17013387.
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    100. Imanishi M, Endres NF, Gennerich A, Vale R. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. J Cell Biol. 2006 Sep 25; 174(7):931-7. PMID: 17000874; PMCID: PMC2064385.
    101. Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale R, Scholey JM. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006 Sep 25; 174(7):1035-45. PMID: 17000880; PMCID: PMC2064394.
    102. Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale R. Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Jul 28; 126(2):335-48. PMID: 16873064; PMCID: PMC2851639.
    103. Mahoney NM, Goshima G, Douglass AD, Vale R. Making microtubules and mitotic spindles in cells without functional centrosomes. Curr Biol. 2006 Mar 21; 16(6):564-9. PMID: 16546079.
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    104. Endres NF, Yoshioka C, Milligan RA, Vale R. A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature. 2006 Feb 16; 439(7078):875-8. PMID: 16382238; PMCID: PMC2851630.
    105. Jambhekar A, McDermott K, Sorber K, Shepard KA, Vale R, Takizawa PA, DeRisi JL. Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18005-10. PMID: 16326802; PMCID: PMC1298916.
    106. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale R. Length control of the metaphase spindle. Curr Biol. 2005 Nov 22; 15(22):1979-88. PMID: 16303556.
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    107. Goshima G, Nédélec F, Vale R. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J Cell Biol. 2005 Oct 24; 171(2):229-40. PMID: 16247025; PMCID: PMC2171195.
    108. Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale R, Portnoy DA. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13646-51. PMID: 16157870; PMCID: PMC1224656.
    109. Dean SO, Rogers SL, Stuurman N, Vale R, Spudich JA. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13473-8. PMID: 16174742; PMCID: PMC1200093.
    110. Dzhindzhev NS, Rogers SL, Vale R, Ohkura H. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J Cell Sci. 2005 Aug 15; 118(Pt 16):3781-90. PMID: 16105886.
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    111. Douglass AD, Vale R. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell. 2005 Jun 17; 121(6):937-50. PMID: 15960980; PMCID: PMC2851620.
    112. Goshima G, Vale R. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell. 2005 Aug; 16(8):3896-907. PMID: 15958489; PMCID: PMC1182325.
    113. Roll-Mecak A, Vale R. The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr Biol. 2005 Apr 12; 15(7):650-5. PMID: 15823537.
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    114. Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale R, Carter AP. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem. 2005 Jun 24; 280(25):23960-5. PMID: 15826937; PMCID: PMC1464088.
    115. Mennella V, Rogers GC, Rogers SL, Buster DW, Vale R, Sharp DJ. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat Cell Biol. 2005 Mar; 7(3):235-45. PMID: 15723056.
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    116. Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale R. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J Cell Biol. 2005 Feb 14; 168(4):587-98. PMID: 15699215.
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    117. Rogers SL, Wiedemann U, Häcker U, Turck C, Vale R. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol. 2004 Oct 26; 14(20):1827-33. PMID: 15498490.
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    118. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale R, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
    119. Reck-Peterson SL, Vale R. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14305. PMID: 15693149; PMCID: PMC521152.
    120. Collins SR, Douglass A, Vale R, Weissman JS. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321. PMID: 15383837; PMCID: PMC517824.
    121. Klopfenstein DR, Vale R. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell. 2004 Aug; 15(8):3729-39. PMID: 15155810; PMCID: PMC491832.
    122. Dell KR, Vale R. A tribute to Shinya Inoue and innovation in light microscopy. J Cell Biol. 2004 Apr; 165(1):21-5. PMID: 15317131; PMCID: PMC2172095.
    123. Reck-Peterson SL, Vale R. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1491-5. PMID: 14755060; PMCID: PMC341754.
    124. Yildiz A, Tomishige M, Vale R, Selvin PR. Kinesin walks hand-over-hand. Science. 2004 Jan 30; 303(5658):676-8. PMID: 14684828.
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    125. Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale R, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22; 427(6972):364-70. PMID: 14681690.
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    126. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale R, Milligan RA. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J Cell Biol. 2003 Nov 24; 163(4):743-53. PMID: 14638858; PMCID: PMC2173678.
    127. Vale R. Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol. 2003 Nov 10; 163(3):445-50. PMID: 14610051; PMCID: PMC2173644.
    128. Goshima G, Vale R. The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol. 2003 Sep 15; 162(6):1003-16. PMID: 12975346; PMCID: PMC2172859.
    129. Rogers SL, Wiedemann U, Stuurman N, Vale R. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol. 2003 Sep 15; 162(6):1079-88. PMID: 12975351; PMCID: PMC2172842.
    130. Yaffe MP, Stuurman N, Vale R. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. PMID: 12972644; PMCID: PMC208773.
    131. Rothenberg ME, Rogers SL, Vale R, Jan LY, Jan YN. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron. 2003 Aug 28; 39(5):779-91. PMID: 12948445.
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    132. Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale R, Kollman PA, Car R, Yount RG, Cooke R, Pate E. Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules. Science. 2003 May 02; 300(5620):798-801. PMID: 12730601.
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    133. Naber N, Rice S, Matuska M, Vale R, Cooke R, Pate E. EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J. 2003 May; 84(5):3190-6. PMID: 12719248; PMCID: PMC1302879.
    134. Vale R. The molecular motor toolbox for intracellular transport. Cell. 2003 Feb 21; 112(4):467-80. PMID: 12600311.
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    135. Tomishige M, Klopfenstein DR, Vale R. Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science. 2002 Sep 27; 297(5590):2263-7. PMID: 12351789.
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    136. Rogers SL, Rogers GC, Sharp DJ, Vale R. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J Cell Biol. 2002 Sep 02; 158(5):873-84. PMID: 12213835; PMCID: PMC2173155.
    137. Klopfenstein DR, Tomishige M, Stuurman N, Vale R. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 2002 May 03; 109(3):347-58. PMID: 12015984; PMCID: PMC2851634.
    138. Irie K, Tadauchi T, Takizawa PA, Vale R, Matsumoto K, Herskowitz I. The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J. 2002 Mar 01; 21(5):1158-67. PMID: 11867544; PMCID: PMC125877.
    139. Klopfenstein DR, Holleran EA, Vale R. Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum. J Muscle Res Cell Motil. 2002; 23(7-8):631-8. PMID: 12952062.
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