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Ron Vale, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
Phone415-476-6380
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    Other Positions
    TitleHoward Hughes Investigator


    Collapse Biography 
    Collapse Awards and Honors
    2014Institute of Medicine Member
    2012Albert Lasker Basic Medical Research Award

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Microtubule-Based Motility
    NIH R35GM118106Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Creating an online resource center for training and professional development in the biomedical sciences
    NIH R25GM116704Sep 25, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Structure and mechanism of the dynein motor
    NIH R01GM097312Apr 1, 2011 - Mar 31, 2019
    Role: Principal Investigator
    Open Source Microscopy Software
    NIH R01EB007187Apr 1, 2007 - Aug 31, 2015
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13GM085967Sep 20, 2004 - May 31, 2018
    Role: Principal Investigator
    Interdisciplinary Training in Quantitative Cell Biology
    NIH R13DK069546Sep 20, 2004 - Jul 31, 2007
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    PROTEIN MODULATORS OF MICROTUBULE DYNAMICS
    NIH R01GM049752Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Microtubule Complexes Involved in Intracelluar Transport
    NIH R37GM038499Feb 1, 1988 - Aug 31, 2016
    Role: Principal Investigator
    Macromoleclar Complexes Involved in Cellular Transport
    NIH R01GM038499Feb 1, 1988 - Aug 31, 2006
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Williamson AP, Vale RD. Spatial control of Draper receptor signaling initiates apoptotic cell engulfment. J Cell Biol. 2018 Aug 23. PMID: 30139739.
      View in: PubMed
    2. Greenan GA, Keszthelyi B, Vale RD, Agard DA. Insights into centriole geometry revealed by cryoTomography of doublet and triplet centrioles. Elife. 2018 Aug 06; 7. PMID: 30080137.
      View in: PubMed
    3. Polka JK, Kiley R, Konforti B, Stern B, Vale RD. Publish peer reviews. Nature. 2018 Aug; 560(7720):545-547. PMID: 30158621.
      View in: PubMed
    4. Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA, Heath JR, Evavold BD, Vale RD, Garcia KC. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell. 2018 Jul 26; 174(3):672-687.e27. PMID: 30053426.
      View in: PubMed
    5. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 Jun 13; 7. PMID: 29897330.
      View in: PubMed
    6. Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale R. Chimeric antigen receptors that trigger phagocytosis. Elife. 2018 Jun 04; 7. PMID: 29862966.
      View in: PubMed
    7. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP. Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 May 08. PMID: 29740130.
      View in: PubMed
    8. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP. The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 Apr 16. PMID: 29662141.
      View in: PubMed
    9. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44):E9338-E9345. PMID: 29042512.
      View in: PubMed
    10. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106. PMID: 28912235.
      View in: PubMed
    11. Huynh W, Vale RD. Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin. J Cell Biol. 2017 10 02; 216(10):3051-3060. PMID: 28883039.
      View in: PubMed
    12. Jain A, Vale RD. RNA phase transitions in repeat expansion disorders. Nature. 2017 06 08; 546(7657):243-247. PMID: 28562589.
      View in: PubMed
    13. Bourne PE, Polka JK, Vale RD, Kiley R. Ten simple rules to consider regarding preprint submission. PLoS Comput Biol. 2017 May; 13(5):e1005473. PMID: 28472041.
      View in: PubMed
    14. Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD. Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. Cell. 2017 Apr 06; 169(2):273-285.e17. PMID: 28388411.
      View in: PubMed
    15. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23; 169(1):108-119.e20. PMID: 28340336.
      View in: PubMed
    16. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. PMID: 28280247.
      View in: PubMed
    17. Su X, Ditlev JA, Rosen MK, Vale RD. Reconstitution of TCR Signaling Using Supported Lipid Bilayers. Methods Mol Biol. 2017; 1584:65-76. PMID: 28255696.
      View in: PubMed
    18. Carbone CB, Vale RD, Stuurman N. An acquisition and analysis pipeline for scanning angle interference microscopy. Nat Methods. 2016 Oct 31; 13(11):897-898. PMID: 27798596.
      View in: PubMed
    19. Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2016 09 29; 13(10):807-809. PMID: 27684577.
      View in: PubMed
    20. Schroeder CM, Vale RD. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J Cell Biol. 2016 08 01; 214(3):309-18. PMID: 27482052.
      View in: PubMed
    21. Stuurman N, Vale RD. Impact of New Camera Technologies on Discoveries in Cell Biology. Biol Bull. 2016 Aug; 231(1):5-13. PMID: 27638691.
      View in: PubMed
    22. Vale RD, Hyman AA. Priority of discovery in the life sciences. Elife. 2016 06 16; 5. PMID: 27310529; PMCID: PMC4911212.
    23. Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C. SCIENTIFIC COMMUNITY. Preprints for the life sciences. Science. 2016 May 20; 352(6288):899-901. PMID: 27199406.
      View in: PubMed
    24. Yan X, Hoek TA, Vale RD, Tanenbaum ME. Dynamics of Translation of Single mRNA Molecules In Vivo. Cell. 2016 May 05; 165(4):976-89. PMID: 27153498; PMCID: PMC4889334.
    25. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. PMID: 27112495; PMCID: PMC4860041 [Available on 05/04/17].
    26. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844; PMCID: PMC4892427 [Available on 10/29/16].
    27. McKenney RJ, Huynh W, Vale RD, Sirajuddin M. Tyrosination of a-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016 06 01; 35(11):1175-85. PMID: 26968983; PMCID: PMC4888239 [Available on 06/01/17].
    28. Bhabha G, Johnson GT, Schroeder CM, Vale RD. How Dynein Moves Along Microtubules. Trends Biochem Sci. 2016 Jan; 41(1):94-105. PMID: 26678005.
      View in: PubMed
    29. Vale RD. Accelerating scientific publication in biology. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):13439-46. PMID: 26508643; PMCID: PMC4640799.
    30. Dell KR, Vale RD. iBioChina and iBiology: spreading scientific knowledge together. Sci China Life Sci. 2015 Nov; 58(11):1180-2. PMID: 26423567.
      View in: PubMed
    31. Yildiz A, Vale RD. Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep 01; 2015(9):pdb.prot086355. PMID: 26330626.
      View in: PubMed
    32. Petry S, Vale RD. Microtubule nucleation at the centrosome and beyond. Nat Cell Biol. 2015 Sep; 17(9):1089-93. PMID: 26316453.
      View in: PubMed
    33. Yildiz A, Vale RD. Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc. 2015 Sep 01; 2015(9):pdb.top086348. PMID: 26330632.
      View in: PubMed
    34. Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD. Regulation of mRNA translation during mitosis. Elife. 2015 Aug 25; 4. PMID: 26305499; PMCID: PMC4548207.
    35. Jonsson E, Yamada M, Vale RD, Goshima G. Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants. Nat Plants. 2015 Jul; 1(7). PMID: 26322239.
      View in: PubMed
    36. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35. PMID: 26125038; PMCID: PMC4479523.
    37. Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015 Apr 15; 194(8):3984-96. PMID: 25762780; PMCID: PMC4390494.
    38. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 06; 159(4):857-68. PMID: 25417161; PMCID: PMC4269335.
    39. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. PMID: 25307933; PMCID: PMC4252608.
    40. Schroeder CM, Ostrem JM, Hertz NT, Vale RD. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. Elife. 2014 Oct 01; 3:e03351. PMID: 25272277; PMCID: PMC4359372.
    41. Ribeiro SA, D'Ambrosio MV, Vale RD. Induction of focal adhesions and motility in Drosophila S2 cells. Mol Biol Cell. 2014 Dec 01; 25(24):3861-9. PMID: 25273555; PMCID: PMC4244196.
    42. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. PMID: 25035494; PMCID: PMC4224444.
    43. Hendershott MC, Vale RD. Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5860-5. PMID: 24706919; PMCID: PMC4000804.
    44. Sirajuddin M, Rice LM, Vale RD. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat Cell Biol. 2014 Apr; 16(4):335-44. PMID: 24633327; PMCID: PMC4117587.
    45. Hui E, Vale RD. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. PMID: 24463463; PMCID: PMC4062301.
    46. Toret CP, D'Ambrosio MV, Vale RD, Simon MA, Nelson WJ. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014 Jan 20; 204(2):265-79. PMID: 24446484; PMCID: PMC3897182.
    47. Vale RD. Preface: the role of reconstitution in cytoskeleton research. Methods Enzymol. 2014; 540:xix-xxiii. PMID: 24630122.
      View in: PubMed
    48. Edelstein AD, Tsuchida MA, Amodaj N, Pinkard H, Vale RD, Stuurman N. Advanced methods of microscope control using µManager software. J Biol Methods. 2014; 1(2). PMID: 25606571.
      View in: PubMed
    49. Moutinho-Pereira S, Stuurman N, Afonso O, Hornsveld M, Aguiar P, Goshima G, Vale RD, Maiato H. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19808-13. PMID: 24255106; PMCID: PMC3856817.
    50. Doyle KM, Vale RD. Creating opportunities for science PhDs to pursue careers in high school education. Mol Biol Cell. 2013 Nov; 24(21):3292-6. PMID: 24174464; PMCID: PMC3814146.
    51. Tanenbaum ME, Vale RD, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2013 Sep 03; 2:e00943. PMID: 24015359; PMCID: PMC3762337.
    52. Vale RD. The value of asking questions. Mol Biol Cell. 2013 Mar; 24(6):680-2. PMID: 23486404; PMCID: PMC3596240.
    53. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77. PMID: 23415226; PMCID: PMC3680348.
    54. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3. PMID: 23258877.
      View in: PubMed
    55. Vale RD. How lucky can one be? A perspective from a young scientist at the right place at the right time. Nat Med. 2012 Oct; 18(10):1486-8. PMID: 23042358.
      View in: PubMed
    56. Vale RD. Evaluating how we evaluate. Mol Biol Cell. 2012 Sep; 23(17):3285-9. PMID: 22936699; PMCID: PMC3431935.
    57. James JR, Vale RD. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature. 2012 Jul 05; 487(7405):64-9. PMID: 22763440; PMCID: PMC3393772.
    58. Zou W, Wang X, Vale RD, Ou G. Autophagy genes promote apoptotic cell corpse clearance. Autophagy. 2012 Aug; 8(8):1267-8. PMID: 22653037.
      View in: PubMed
    59. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X, Vale RD, Ou G. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol. 2012 Apr 02; 197(1):27-35. PMID: 22451698; PMCID: PMC3317810.
    60. Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale RD, Jülicher F, Reck-Peterson SL, Dogterom M. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Feb 03; 148(3):502-14. PMID: 22304918; PMCID: PMC3292199.
    61. Petry S, Vale RD. A new cap for kinetochore fibre minus ends. Nat Cell Biol. 2011 Nov 13; 13(12):1389-91. PMID: 22081093; PMCID: PMC3532025.
    62. Cho C, Vale RD. The mechanism of dynein motility: insight from crystal structures of the motor domain. Biochim Biophys Acta. 2012 Jan; 1823(1):182-91. PMID: 22062687; PMCID: PMC3249483.
    63. Petry S, Pugieux C, Nédélec FJ, Vale RD. Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14473-8. PMID: 21844347; PMCID: PMC3167534.
    64. Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G. The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr Biol. 2011 Jun 07; 21(11):948-54. PMID: 21596567; PMCID: PMC3109113.
    65. Carter AP, Cho C, Jin L, Vale RD. Crystal structure of the dynein motor domain. Science. 2011 Mar 04; 331(6021):1159-65. PMID: 21330489; PMCID: PMC3169322.
    66. Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale RD. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 2011 Mar 04; 286(9):7457-67. PMID: 21169635; PMCID: PMC3045001.
    67. Yudushkin IA, Vale RD. Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3? in the endosomal compartment. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22128-33. PMID: 21135224; PMCID: PMC3009781.
    68. D'Ambrosio MV, Vale RD. A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Biol. 2010 Nov 01; 191(3):471-8. PMID: 21041442; PMCID: PMC3003316.
    69. Goodwin SS, Vale RD. Patronin regulates the microtubule network by protecting microtubule minus ends. Cell. 2010 Oct 15; 143(2):263-74. PMID: 20946984; PMCID: PMC3008421.
    70. Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N. Computer control of microscopes using µManager. Curr Protoc Mol Biol. 2010 Oct; Chapter 14:Unit14.20. PMID: 20890901; PMCID: PMC3065365.
    71. Ou G, Stuurman N, D'Ambrosio M, Vale RD. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010 Oct 29; 330(6004):677-80. PMID: 20929735; PMCID: PMC3032534.
    72. Tole S, Vale RD. Young leaders for biology in India. Science. 2010 Sep 17; 329(5998):1441. PMID: 20847237.
      View in: PubMed
    73. Yu CH, Wu HJ, Kaizuka Y, Vale RD, Groves JT. Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS One. 2010 Jul 29; 5(7):e11878. PMID: 20686692; PMCID: PMC2912367.
    74. Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER. Determinants of myosin II cortical localization during cytokinesis. Curr Biol. 2010 Jun 22; 20(12):1080-5. PMID: 20541410; PMCID: PMC2930192.
    75. Carter AP, Vale RD. Communication between the AAA+ ring and microtubule-binding domain of dynein. Biochem Cell Biol. 2010 Feb; 88(1):15-21. PMID: 20130675; PMCID: PMC2894566.
    76. Vale RD. It's a wonderful life: a career as an academic scientist. Mol Biol Cell. 2010 Jan 01; 21(1):11-4. PMID: 20048258; PMCID: PMC2801704.
    77. Kardon JR, Vale RD. Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol. 2009 Dec; 10(12):854-65. PMID: 19935668; PMCID: PMC3394690.
    78. Vale RD, Spudich JA, Griffis ER. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol. 2009 Sep 07; 186(5):727-38. PMID: 19720876; PMCID: PMC2742194.
    79. DePristo MA, Chang L, Vale RD, Khan SM, Lipkow K. Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy. Prog Biophys Mol Biol. 2009 Sep-Oct; 100(1-3):25-32. PMID: 19628003; PMCID: PMC2805826.
    80. Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale RD. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol. 2009 May 04; 185(3):521-34. PMID: 19398758; PMCID: PMC2700390.
    81. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6998-7003. PMID: 19369198.
      View in: PubMed
    82. Ou G, Vale RD. Molecular signatures of cell migration in C. elegans Q neuroblasts. J Cell Biol. 2009 Apr 06; 185(1):77-85. PMID: 19349580; PMCID: PMC2700521.
    83. Kardon JR, Reck-Peterson SL, Vale RD. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5669-74. PMID: 19293377; PMCID: PMC2657088.
    84. Vale RD, Dell K. The biological sciences in India: aiming high for the future. J Cell Biol. 2009 Feb 09; 184(3):342-53. PMID: 19204144; PMCID: PMC2646550.
    85. Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol. 2009 Feb; 21(1):59-67. PMID: 19179063; PMCID: PMC2668149.
    86. Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale RD, Gibbons IR. Structure and functional role of dynein's microtubule-binding domain. Science. 2008 Dec 12; 322(5908):1691-5. PMID: 19074350; PMCID: PMC2663340.
    87. Vale RD. Microscopes for fluorimeters: the era of single molecule measurements. Cell. 2008 Nov 28; 135(5):779-85. PMID: 19041739; PMCID: PMC2762818.
    88. Yildiz A, Tomishige M, Gennerich A, Vale RD. Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell. 2008 Sep 19; 134(6):1030-41. PMID: 18805095; PMCID: PMC2613771.
    89. Cho C, Reck-Peterson SL, Vale RD. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem. 2008 Sep 19; 283(38):25839-45. PMID: 18650442; PMCID: PMC2533788.
    90. Goshima G, Mayer M, Zhang N, Stuurman N, Vale RD. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol. 2008 May 05; 181(3):421-9. PMID: 18443220; PMCID: PMC2364697.
    91. Trammell MA, Mahoney NM, Agard DA, Vale RD. Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci. 2008 Apr 15; 121(Pt 8):1284-92. PMID: 18388316; PMCID: PMC2851640.
    92. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709; PMCID: PMC2734507.
    93. Roll-Mecak A, Vale RD. Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature. 2008 Jan 17; 451(7176):363-7. PMID: 18202664; PMCID: PMC2882799.
    94. Douglass AD, Vale RD. Single-molecule imaging of fluorescent proteins. Methods Cell Biol. 2008; 85:113-25. PMID: 18155461.
      View in: PubMed
    95. Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD. Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20296-301. PMID: 18077330; PMCID: PMC2154425.
    96. Gennerich A, Carter AP, Reck-Peterson SL, Vale RD. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Nov 30; 131(5):952-65. PMID: 18045537; PMCID: PMC2851641.
    97. Mori T, Vale RD, Tomishige M. How kinesin waits between steps. Nature. 2007 Nov 29; 450(7170):750-4. PMID: 18004302.
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    98. Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. J Biol Chem. 2007 Nov 30; 282(48):34748-57. PMID: 17911103.
      View in: PubMed
    99. Slep KC, Vale RD. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Mol Cell. 2007 Sep 21; 27(6):976-91. PMID: 17889670; PMCID: PMC2052927.
    100. Griffis ER, Stuurman N, Vale RD. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007 Jun 18; 177(6):1005-15. PMID: 17576797; PMCID: PMC2064361.
    101. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale RD, Stuurman N. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science. 2007 Apr 20; 316(5823):417-21. PMID: 17412918; PMCID: PMC2837481.
    102. Roll-Mecak A, Vale RD. Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? J Cell Biol. 2006 Dec 18; 175(6):849-51. PMID: 17178905; PMCID: PMC2064694.
    103. Tomishige M, Stuurman N, Vale RD. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol. 2006 Oct; 13(10):887-94. PMID: 17013387.
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    104. Imanishi M, Endres NF, Gennerich A, Vale RD. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. J Cell Biol. 2006 Sep 25; 174(7):931-7. PMID: 17000874; PMCID: PMC2064385.
    105. Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale RD, Scholey JM. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006 Sep 25; 174(7):1035-45. PMID: 17000880; PMCID: PMC2064394.
    106. Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale RD. Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Jul 28; 126(2):335-48. PMID: 16873064; PMCID: PMC2851639.
    107. Mahoney NM, Goshima G, Douglass AD, Vale RD. Making microtubules and mitotic spindles in cells without functional centrosomes. Curr Biol. 2006 Mar 21; 16(6):564-9. PMID: 16546079.
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    108. Endres NF, Yoshioka C, Milligan RA, Vale RD. A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature. 2006 Feb 16; 439(7078):875-8. PMID: 16382238; PMCID: PMC2851630.
    109. Jambhekar A, McDermott K, Sorber K, Shepard KA, Vale RD, Takizawa PA, DeRisi JL. Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18005-10. PMID: 16326802; PMCID: PMC1298916.
    110. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale RD. Length control of the metaphase spindle. Curr Biol. 2005 Nov 22; 15(22):1979-88. PMID: 16303556.
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    111. Goshima G, Nédélec F, Vale RD. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J Cell Biol. 2005 Oct 24; 171(2):229-40. PMID: 16247025; PMCID: PMC2171195.
    112. Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale RD, Portnoy DA. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13646-51. PMID: 16157870; PMCID: PMC1224656.
    113. Dean SO, Rogers SL, Stuurman N, Vale RD, Spudich JA. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13473-8. PMID: 16174742; PMCID: PMC1200093.
    114. Dzhindzhev NS, Rogers SL, Vale RD, Ohkura H. Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J Cell Sci. 2005 Aug 15; 118(Pt 16):3781-90. PMID: 16105886.
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    115. Douglass AD, Vale RD. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell. 2005 Jun 17; 121(6):937-50. PMID: 15960980; PMCID: PMC2851620.
    116. Goshima G, Vale RD. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Mol Biol Cell. 2005 Aug; 16(8):3896-907. PMID: 15958489; PMCID: PMC1182325.
    117. Roll-Mecak A, Vale RD. The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr Biol. 2005 Apr 12; 15(7):650-5. PMID: 15823537.
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    118. Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale RD, Carter AP. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem. 2005 Jun 24; 280(25):23960-5. PMID: 15826937; PMCID: PMC1464088.
    119. Mennella V, Rogers GC, Rogers SL, Buster DW, Vale RD, Sharp DJ. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat Cell Biol. 2005 Mar; 7(3):235-45. PMID: 15723056.
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    120. Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale RD. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J Cell Biol. 2005 Feb 14; 168(4):587-98. PMID: 15699215.
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    121. Rogers SL, Wiedemann U, Häcker U, Turck C, Vale RD. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol. 2004 Oct 26; 14(20):1827-33. PMID: 15498490.
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    122. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
    123. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14305. PMID: 15693149; PMCID: PMC521152.
    124. Collins SR, Douglass A, Vale RD, Weissman JS. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321. PMID: 15383837; PMCID: PMC517824.
    125. Klopfenstein DR, Vale RD. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell. 2004 Aug; 15(8):3729-39. PMID: 15155810; PMCID: PMC491832.
    126. Dell KR, Vale RD. A tribute to Shinya Inoue and innovation in light microscopy. J Cell Biol. 2004 Apr; 165(1):21-5. PMID: 15317131; PMCID: PMC2172095.
    127. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1491-5. PMID: 14755060; PMCID: PMC341754.
    128. Yildiz A, Tomishige M, Vale RD, Selvin PR. Kinesin walks hand-over-hand. Science. 2004 Jan 30; 303(5658):676-8. PMID: 14684828.
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    129. Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22; 427(6972):364-70. PMID: 14681690.
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    130. Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale RD, Milligan RA. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J Cell Biol. 2003 Nov 24; 163(4):743-53. PMID: 14638858; PMCID: PMC2173678.
    131. Vale RD. Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol. 2003 Nov 10; 163(3):445-50. PMID: 14610051; PMCID: PMC2173644.
    132. Goshima G, Vale RD. The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J Cell Biol. 2003 Sep 15; 162(6):1003-16. PMID: 12975346; PMCID: PMC2172859.
    133. Rogers SL, Wiedemann U, Stuurman N, Vale RD. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol. 2003 Sep 15; 162(6):1079-88. PMID: 12975351; PMCID: PMC2172842.
    134. Yaffe MP, Stuurman N, Vale RD. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. PMID: 12972644; PMCID: PMC208773.
    135. Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN. Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron. 2003 Aug 28; 39(5):779-91. PMID: 12948445.
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    136. Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E. Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules. Science. 2003 May 02; 300(5620):798-801. PMID: 12730601.
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    137. Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E. EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J. 2003 May; 84(5):3190-6. PMID: 12719248; PMCID: PMC1302879.
    138. Vale RD. The molecular motor toolbox for intracellular transport. Cell. 2003 Feb 21; 112(4):467-80. PMID: 12600311.
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    139. Tomishige M, Klopfenstein DR, Vale RD. Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science. 2002 Sep 27; 297(5590):2263-7. PMID: 12351789.
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    140. Rogers SL, Rogers GC, Sharp DJ, Vale RD. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J Cell Biol. 2002 Sep 02; 158(5):873-84. PMID: 12213835; PMCID: PMC2173155.
    141. Klopfenstein DR, Tomishige M, Stuurman N, Vale RD. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 2002 May 03; 109(3):347-58. PMID: 12015984; PMCID: PMC2851634.
    142. Irie K, Tadauchi T, Takizawa PA, Vale RD, Matsumoto K, Herskowitz I. The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J. 2002 Mar 01; 21(5):1158-67. PMID: 11867544; PMCID: PMC125877.
    143. Klopfenstein DR, Holleran EA, Vale RD. Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum. J Muscle Res Cell Motil. 2002; 23(7-8):631-8. PMID: 12952062.
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