Slavena Vylkova, PhD

Title(s)Project Manager Scientific Com, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #357
San Francisco CA 94143
ORCID ORCID Icon0000-0002-0051-4664 Additional info
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    Collapse Biography 
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    Sofia University, Sofia, BulgariaMS2001molecular biology
    State University of New York at Buffalo, Buffalo, NYMS2004Oral Sciences
    State University of New York at Buffalo, Buffalo, NYPhD2007Oral Biology

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    Dr. Slavena Vylkova manages the scientific communications for the Benioff Center for Microbiome Medicine (BCMM). Her responsibilities include assisting with pre-award research funding operations, scientific writing/editing and project development.
    Previously, Slavena was a research assistant professor at Friedrich Schiller University in Jena, Germany, where she led a research group focusing on the molecular basis of metabolic adaptation of the fungal pathogen Candida albicans to the host niches and associated microbiota. She received her PhD in Oral Biology from State University of New York at Buffalo with Dr. Mira Edgerton and her postdoctoral training in Dr. Michael Lorenz's laboratory in McGovern Medical School in Houston, TX.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A highly conserved tRNA modification contributes to C. albicans filamentation and virulence. Microbiol Spectr. 2024 Apr 08; e0425522. Böttcher B, Kienast SD, Leufken J, Eggers C, Sharma P, Leufken CM, Morgner B, Drexler HCA, Schulz D, Allert S, Jacobsen ID, Vylkova S, Leidel SA, Brunke S. PMID: 38587411.
      View in: PubMed   Mentions:
    2. Escherichia coli Nissle 1917 Antagonizes Candida albicans Growth and Protects Intestinal Cells from C. albicans-Mediated Damage. Microorganisms. 2023 Jul 28; 11(8). Rebai Y, Wagner L, Gnaien M, Hammer ML, Kapitan M, Niemiec MJ, Mami W, Mosbah A, Messadi E, Mardassi H, Vylkova S, Jacobsen ID, Znaidi S. PMID: 37630490; PMCID: PMC10457924.
      View in: PubMed   Mentions:
    3. Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity. Nat Commun. 2023 06 05; 14(1):3239. Häder A, Schäuble S, Gehlen J, Thielemann N, Buerfent BC, Schüller V, Hess T, Wolf T, Schröder J, Weber M, Hünniger K, Löffler J, Vylkova S, Panagiotou G, Schumacher J, Kurzai O. PMID: 37277347; PMCID: PMC10241821.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences. Microbiol Spectr. 2023 06 15; 11(3):e0049823. Brandt P, Mirhakkak MH, Wagner L, Driesch D, Möslinger A, Fänder P, Schäuble S, Panagiotou G, Vylkova S. PMID: 37097196; PMCID: PMC10269459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Integrated analysis of SR-like protein kinases Sky1 and Sky2 links signaling networks with transcriptional regulation in Candida albicans. Front Cell Infect Microbiol. 2023; 13:1108235. Luther CH, Brandt P, Vylkova S, Dandekar T, Müller T, Dittrich M. PMID: 37082713; PMCID: PMC10111165.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Functional analysis of the Candida albicans ECE1 Promoter. Microbiol Spectr. 2023 Feb 14; e0025323. Garbe E, Thielemann N, Hohner S, Kumar A, Vylkova S, Kurzai O, Martin R. PMID: 36786567; PMCID: PMC10100963.
      View in: PubMed   Mentions: 1     Fields:    
    7. Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation. mSystems. 2022 Oct 20; e0053922. Garbe E, Gerwien F, Driesch D, Müller T, Böttcher B, Gräler M, Vylkova S. PMID: 36264075.
      View in: PubMed   Mentions: 4     Fields:    
    8. Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms. NPJ Biofilms Microbiomes. 2022 10 13; 8(1):78. Böttcher B, Driesch D, Krüger T, Garbe E, Gerwien F, Kniemeyer O, Brakhage AA, Vylkova S. PMID: 36224215; PMCID: PMC9556537.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity. Nat Commun. 2022 06 09; 13(1):3192. Alonso-Roman R, Last A, Mirhakkak MH, Sprague JL, Möller L, Großmann P, Graf K, Gratz R, Mogavero S, Vylkova S, Panagiotou G, Schäuble S, Hube B, Gresnigt MS. PMID: 35680868; PMCID: PMC9184479.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    10. Candida albicans SR-Like Protein Kinases Regulate Different Cellular Processes: Sky1 Is Involved in Control of Ion Homeostasis, While Sky2 Is Important for Dipeptide Utilization. Front Cell Infect Microbiol. 2022; 12:850531. Brandt P, Gerwien F, Wagner L, Krüger T, Ramírez-Zavala B, Mirhakkak MH, Schäuble S, Kniemeyer O, Panagiotou G, Brakhage AA, Morschhäuser J, Vylkova S. PMID: 35601106; PMCID: PMC9121809.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. GNP2 Encodes a High-Specificity Proline Permease in Candida albicans. mBio. 2022 02 22; 13(1):e0314221. Garbe E, Miramón P, Gerwien F, Ueberschaar N, Hansske-Braun L, Brandt P, Böttcher B, Lorenz M, Vylkova S. PMID: 35073760; PMCID: PMC8787483.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    12. Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J. 2021 05; 15(5):1257-1270. Mirhakkak MH, Schäuble S, Klassert TE, Brunke S, Brandt P, Loos D, Uribe RV, Senne de Oliveira Lino F, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss GJ, Sommer MOA, Panagiotou G. PMID: 33323978; PMCID: PMC8115155.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants. Sci Rep. 2020 12 11; 10(1):21818. von Müller C, Bulman F, Wagner L, Rosenberger D, Marolda A, Kurzai O, Eißmann P, Jacobsen ID, Perner B, Hemmerich P, Vylkova S. PMID: 33311597; PMCID: PMC7732850.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. Bloodstream infection due to Enterobacter ludwigii, correlating with massive aggregation on the surface of a central venous catheter. Infection. 2020 Dec; 48(6):955-958. Wagner L, Bloos F, Vylkova S. PMID: 32880846; PMCID: PMC7674343.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Catch the wave: Metabolomic analyses in human pathogenic fungi. PLoS Pathog. 2020 08; 16(8):e1008757. Brandt P, Garbe E, Vylkova S. PMID: 32817633; PMCID: PMC7440615.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    16. Clinical Candida albicans Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions. mSphere. 2020 08 19; 5(4). Gerwien F, Dunker C, Brandt P, Garbe E, Jacobsen ID, Vylkova S. PMID: 32817377; PMCID: PMC7407065.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. The Transcription Factor Stp2 Is Important for Candida albicans Biofilm Establishment and Sustainability. Front Microbiol. 2020; 11:794. Böttcher B, Hoffmann B, Garbe E, Weise T, Cseresnyés Z, Brandt P, Dietrich S, Driesch D, Figge MT, Vylkova S. PMID: 32425915; PMCID: PMC7203782.
      View in: PubMed   Mentions: 8  
    18. Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans. mBio. 2020 04 28; 11(2). Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, Häder A, Krüger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, Hünniger K, Kniemeyer O, Brakhage AA, Morschhäuser J, Hube B, Vylkova S, Kurzai O, Martin R. PMID: 32345638; PMCID: PMC7188989.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    19. Environmental pH modulation by pathogenic fungi as a strategy to conquer the host. PLoS Pathog. 2017 02; 13(2):e1006149. Vylkova S. PMID: 28231317; PMCID: PMC5322887.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    20. Phagosomal Neutralization by the Fungal Pathogen Candida albicans Induces Macrophage Pyroptosis. Infect Immun. 2017 02; 85(2). Vylkova S, Lorenz MC. PMID: 27872238; PMCID: PMC5278172.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    21. Robust Extracellular pH Modulation by Candida albicans during Growth in Carboxylic Acids. mBio. 2016 11 15; 7(6). Danhof HA, Vylkova S, Vesely EM, Ford AE, Gonzalez-Garay M, Lorenz MC. PMID: 27935835; PMCID: PMC5111404.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    22. Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport. PLoS Pathog. 2014 Mar; 10(3):e1003995. Vylkova S, Lorenz MC. PMID: 24626429; PMCID: PMC3953444.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    23. The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH. mBio. 2011; 2(3):e00055-11. Vylkova S, Carman AJ, Danhof HA, Collette JR, Zhou H, Lorenz MC. PMID: 21586647; PMCID: PMC3101780.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimals
    24. Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans. FEMS Yeast Res. 2009 Mar; 9(2):278-92. Miranda M, Bashi E, Vylkova S, Edgerton M, Slayman C, Rivetta A. PMID: 19175416.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Role of acetyl coenzyme A synthesis and breakdown in alternative carbon source utilization in Candida albicans. Eukaryot Cell. 2008 Oct; 7(10):1733-41. Carman AJ, Vylkova S, Lorenz MC. PMID: 18689527; PMCID: PMC2568070.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    26. Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway. Eukaryot Cell. 2007 Oct; 6(10):1876-88. Vylkova S, Jang WS, Li W, Nayyar N, Edgerton M. PMID: 17715369; PMCID: PMC2043398.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    27. The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides. Purinergic Signal. 2007 Mar; 3(1-2):91-7. Vylkova S, Sun JN, Edgerton M. PMID: 18404422; PMCID: PMC2096768.
      View in: PubMed   Mentions: 20     Fields:    
    28. Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption. Antimicrob Agents Chemother. 2007 Jan; 51(1):154-61. Vylkova S, Nayyar N, Li W, Edgerton M. PMID: 17074797; PMCID: PMC1797696.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    29. Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides. Antimicrob Agents Chemother. 2006 Jan; 50(1):324-31. Vylkova S, Li XS, Berner JC, Edgerton M. PMID: 16377704; PMCID: PMC1346820.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    30. The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5. J Biol Chem. 2004 Dec 31; 279(53):55060-72. Baev D, Rivetta A, Vylkova S, Sun JN, Zeng GF, Slayman CL, Edgerton M. PMID: 15485849.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans. J Dent Res. 2003 Sep; 82(9):748-52. Dong J, Vylkova S, Li XS, Edgerton M. PMID: 12939362.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. Infect Immun. 2003 Jun; 71(6):3251-60. Baev D, Rivetta A, Li XS, Vylkova S, Bashi E, Slayman CL, Edgerton M. PMID: 12761106; PMCID: PMC155775.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
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