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Sandy Johnson, PHD

Title(s)Professor, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-476-8783
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    Collapse Research 
    Collapse Research Activities and Funding
    The transcriptional circuitry controlling biofilm development in Candida albicans
    NIH R01AI083311Jul 1, 2009 - Nov 30, 2020
    Role: Principal Investigator
    Chromosome loss in the fungal pathogen C. albicans
    NIH R01AI059401Mar 15, 2004 - Feb 28, 2010
    Role: Principal Investigator
    Regulatory Circuits and Virulence in Candida albicans
    NIH R01AI049187Mar 1, 2001 - Nov 30, 2016
    Role: Principal Investigator
    TRANSCRIPTIONAL REGULATION IN GROWTH,DIFF,DEVELOPMENT
    NIH R13HD038716Aug 4, 2000 - Jul 31, 2001
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    CHROMOSOME POSITION EFFECTS ON GENE EXPRESSION IN YEAST
    NIH R01GM053452Sep 30, 1995 - Mar 31, 2000
    Role: Principal Investigator
    MEIOTIC PAIRING OF CHROMOSOMES IN YEAST
    NIH R01GM044532Apr 1, 1991 - Mar 31, 1994
    Role: Principal Investigator
    Mechanism of Yeast Transcriptional Regulators
    NIH R01GM037049Aug 1, 1986 - Mar 31, 2019
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH/NIGMS T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Principal Investigator
    Molecular Biology of Eukaryotic Cells and Viruses
    NIH/NCI T32CA009270Sep 1, 1976 - Jun 30, 2006
    Role: Principal Investigator
    DNA-PROTEIN INTERACTIONS IN DNA-REPLICATION CONTROL
    NIH/NIGMS R01GM024020Sep 1, 1976 - Aug 31, 1996
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Takagi J, Singh-Babak SD, Lohse MB, Dalal CK, Johnson AD. Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection. PLoS One. 2019; 14(6):e0218037. PMID: 31170229.
      View in: PubMed
    2. Sorrells TR, Johnson AN, Howard CJ, Britton CS, Fowler KR, Feigerle JT, Weil PA, Johnson AD. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. Elife. 2018 09 10; 7. PMID: 30198843.
      View in: PubMed
    3. Johnson AD. The rewiring of transcription circuits in evolution. Curr Opin Genet Dev. 2017 Dec; 47:121-127. PMID: 29120735.
      View in: PubMed
    4. Lohse MB, Gulati M, Johnson AD, Nobile CJ. Development and regulation of single- and multi-species Candida albicans biofilms. Nat Rev Microbiol. 2018 Jan; 16(1):19-31. PMID: 29062072.
      View in: PubMed
    5. Craik VB, Johnson AD, Lohse MB. Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs. Antimicrob Agents Chemother. 2017 08; 61(8). PMID: 28507115.
      View in: PubMed
    6. Dalal CK, Johnson AD. How transcription circuits explore alternative architectures while maintaining overall circuit output. Genes Dev. 2017 07 15; 31(14):1397-1405. PMID: 28860157.
      View in: PubMed
    7. Lohse MB, Gulati M, Valle Arevalo A, Fishburn A, Johnson AD, Nobile CJ. Assessment and Optimizations of Candida albicans In Vitro Biofilm Assays. Antimicrob Agents Chemother. 2017 05; 61(5). PMID: 28289028.
      View in: PubMed
    8. Nocedal I, Mancera E, Johnson AD. Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator. Elife. 2017 03 22; 6. PMID: 28327289.
      View in: PubMed
    9. Guajardo I, Ayer A, Johnson AD, Ganz P, Mills C, Donovan C, Scherzer R, Shah SJ, Peralta CA, Dubin RF. Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study. Hemodial Int. 2018 01; 22(1):93-102. PMID: 28272770.
      View in: PubMed
    10. Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ. Global Identification of Biofilm-Specific Proteolysis in Candida albicans. MBio. 2016 09 13; 7(5). PMID: 27624133; PMCID: PMC5021810.
    11. Dalal CK, Zuleta IA, Mitchell KF, Andes DR, El-Samad H, Johnson AD. Transcriptional rewiring over evolutionary timescales changes quantitative and qualitative properties of gene expression. Elife. 2016 09 10; 5. PMID: 27614020.
      View in: PubMed
    12. Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD. Systematic Genetic Screen for Transcriptional Regulators of the Candida albicans White-Opaque Switch. Genetics. 2016 08; 203(4):1679-92. PMID: 27280690; PMCID: PMC4981270 [Available on 08/01/17].
    13. Hernday AD, Lohse MB, Nobile CJ, Noiman L, Laksana CN, Johnson AD. Ssn6 Defines a New Level of Regulation of White-Opaque Switching in Candida albicans and Is Required For the Stochasticity of the Switch. MBio. 2016 Jan 26; 7(1):e01565-15. PMID: 26814177.
      View in: PubMed
    14. Lohse MB, Johnson AD. Identification and Characterization of Wor4, a New Transcriptional Regulator of White-Opaque Switching. G3 (Bethesda). 2016 Jan 15; 6(3):721-9. PMID: 26772749; PMCID: PMC4777133.
    15. Nocedal I, Johnson AD. How Transcription Networks Evolve and Produce Biological Novelty. Cold Spring Harb Symp Quant Biol. 2015; 80:265-74. PMID: 26657905.
      View in: PubMed
    16. Sorrells TR, Booth LN, Tuch BB, Johnson AD. Intersecting transcription networks constrain gene regulatory evolution. Nature. 2015 Jul 16; 523(7560):361-5. PMID: 26153861.
      View in: PubMed
    17. Sorrells TR, Johnson AD. Making sense of transcription networks. Cell. 2015 May 07; 161(4):714-23. PMID: 25957680.
      View in: PubMed
    18. Fox EP, Bui CK, Nett JE, Hartooni N, Mui MC, Andes DR, Nobile CJ, Johnson AD. An expanded regulatory network temporally controls Candida albicans biofilm formation. Mol Microbiol. 2015 Jun; 96(6):1226-39. PMID: 25784162; PMCID: PMC4464956.
    19. Fox EP, Cowley ES, Nobile CJ, Hartooni N, Newman DK, Johnson AD. Anaerobic bacteria grow within Candida albicans biofilms and induce biofilm formation in suspension cultures. Curr Biol. 2014 Oct 20; 24(20):2411-6. PMID: 25308076; PMCID: PMC4252622.
    20. Pérez JC, Fordyce PM, Lohse MB, Hanson-Smith V, DeRisi JL, Johnson AD. How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes. Genes Dev. 2014 Jun 15; 28(12):1272-7. PMID: 24874988; PMCID: PMC4066398.
    21. Pérez JC, Johnson AD. Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host. PLoS Pathog. 2013; 9(12):e1003780. PMID: 24385896.
      View in: PubMed
    22. Baker CR, Hanson-Smith V, Johnson AD. Following gene duplication, paralog interference constrains transcriptional circuit evolution. Science. 2013 Oct 04; 342(6154):104-8. PMID: 24092741; PMCID: PMC3911913.
    23. Hernday AD, Lohse MB, Fordyce PM, Nobile CJ, DeRisi JL, Johnson AD. Structure of the transcriptional network controlling white-opaque switching in Candida albicans. Mol Microbiol. 2013 Oct; 90(1):22-35. PMID: 23855748; PMCID: PMC3888361.
    24. Lohse MB, Hernday AD, Fordyce PM, Noiman L, Sorrells TR, Hanson-Smith V, Nobile CJ, DeRisi JL, Johnson AD. Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7660-5. PMID: 23610392; PMCID: PMC3651432.
    25. Pérez JC, Kumamoto CA, Johnson AD. Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol. 2013; 11(3):e1001510. PMID: 23526879; PMCID: PMC3601966.
    26. Baker CR, Booth LN, Sorrells TR, Johnson AD. Protein modularity, cooperative binding, and hybrid regulatory states underlie transcriptional network diversification. Cell. 2012 Sep 28; 151(1):80-95. PMID: 23021217.
      View in: PubMed
    27. Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell. 2012 Jan 20; 148(1-2):126-38. PMID: 22265407; PMCID: PMC3266547.
    28. Cain CW, Lohse MB, Homann OR, Sil A, Johnson AD. A conserved transcriptional regulator governs fungal morphology in widely diverged species. Genetics. 2012 Feb; 190(2):511-21. PMID: 22095082; PMCID: PMC3276625.
    29. Baker CR, Tuch BB, Johnson AD. Extensive DNA-binding specificity divergence of a conserved transcription regulator. Proc Natl Acad Sci U S A. 2011 May 03; 108(18):7493-8. PMID: 21498688; PMCID: PMC3088634.
    30. Booth LN, Tuch BB, Johnson AD. Intercalation of a new tier of transcription regulation into an ancient circuit. Nature. 2010 Dec 16; 468(7326):959-63. PMID: 21164485; PMCID: PMC3254258.
    31. Mitrovich QM, Tuch BB, De La Vega FM, Guthrie C, Johnson AD. Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science. 2010 Nov 05; 330(6005):838-41. PMID: 21051641; PMCID: PMC3496775.
    32. Li H, Johnson AD. Evolution of transcription networks--lessons from yeasts. Curr Biol. 2010 Sep 14; 20(17):R746-53. PMID: 20833319; PMCID: PMC3438143.
    33. Lohse MB, Johnson AD. Temporal anatomy of an epigenetic switch in cell programming: the white-opaque transition of C. albicans. Mol Microbiol. 2010 Oct; 78(2):331-43. PMID: 20735781; PMCID: PMC3057202.
    34. Tuch BB, Mitrovich QM, Homann OR, Hernday AD, Monighetti CK, De La Vega FM, Johnson AD. The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation. PLoS Genet. 2010 Aug 19; 6(8):e1001070. PMID: 20808890; PMCID: PMC2924316.
    35. Lohse MB, Zordan RE, Cain CW, Johnson AD. Distinct class of DNA-binding domains is exemplified by a master regulator of phenotypic switching in Candida albicans. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14105-10. PMID: 20660774.
      View in: PubMed
    36. Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet. 2010 Jul; 42(7):590-8. PMID: 20543849; PMCID: PMC2893244.
    37. Homann OR, Johnson AD. MochiView: versatile software for genome browsing and DNA motif analysis. BMC Biol. 2010 Apr 21; 8:49. PMID: 20409324; PMCID: PMC2867778.
    38. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. Genetics and molecular biology in Candida albicans. Methods Enzymol. 2010; 470:737-58. PMID: 20946834.
      View in: PubMed
    39. Homann OR, Dea J, Noble SM, Johnson AD. A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 2009 Dec; 5(12):e1000783. PMID: 20041210.
      View in: PubMed
    40. Lohse MB, Johnson AD. White-opaque switching in Candida albicans. Curr Opin Microbiol. 2009 Dec; 12(6):650-4. PMID: 19853498; PMCID: PMC2812476.
    41. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6. PMID: 19779198; PMCID: PMC2813701.
    42. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 2009 Sep; 5(9):e1000664. PMID: 19779551.
      View in: PubMed
    43. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58. PMID: 19089394.
      View in: PubMed
    44. Tuch BB, Li H, Johnson AD. Evolution of eukaryotic transcription circuits. Science. 2008 Mar 28; 319(5871):1797-9. PMID: 18369141.
      View in: PubMed
    45. Tuch BB, Galgoczy DJ, Hernday AD, Li H, Johnson AD. The evolution of combinatorial gene regulation in fungi. PLoS Biol. 2008 Feb; 6(2):e38. PMID: 18303948; PMCID: PMC2253631.
    46. Lohse MB, Johnson AD. Differential phagocytosis of white versus opaque Candida albicans by Drosophila and mouse phagocytes. PLoS One. 2008 Jan 23; 3(1):e1473. PMID: 18213381; PMCID: PMC2198939.
    47. Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD. Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans. PLoS Biol. 2007 Oct; 5(10):e256. PMID: 17880264; PMCID: PMC1976629.
    48. Mitrovich QM, Tuch BB, Guthrie C, Johnson AD. Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans. Genome Res. 2007 Apr; 17(4):492-502. PMID: 17351132; PMCID: PMC1832096.
    49. Noble SM, Johnson AD. Genetics of Candida albicans, a diploid human fungal pathogen. Annu Rev Genet. 2007; 41:193-211. PMID: 17614788.
      View in: PubMed
    50. Bennett RJ, Johnson AD. The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans. Mol Microbiol. 2006 Oct; 62(1):100-19. PMID: 16987174.
      View in: PubMed
    51. Tsong AE, Tuch BB, Li H, Johnson AD. Evolution of alternative transcriptional circuits with identical logic. Nature. 2006 Sep 28; 443(7110):415-20. PMID: 17006507.
      View in: PubMed
    52. Zordan RE, Galgoczy DJ, Johnson AD. Epigenetic properties of white-opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loop. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12807-12. PMID: 16899543; PMCID: PMC1535343.
    53. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006 Jan; 4(1):e4. PMID: 16336044.
      View in: PubMed
    54. Hromatka BS, Noble SM, Johnson AD. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell. 2005 Oct; 16(10):4814-26. PMID: 16030247.
      View in: PubMed
    55. Braun BR, van Het Hoog M, d'Enfert C, Martchenko M, Dungan J, Kuo A, Inglis DO, Uhl MA, Hogues H, Berriman M, Lorenz M, Levitin A, Oberholzer U, Bachewich C, Harcus D, Marcil A, Dignard D, Iouk T, Zito R, Frangeul L, Tekaia F, Rutherford K, Wang E, Munro CA, Bates S, Gow NA, Hoyer LL, Köhler G, Morschhäuser J, Newport G, Znaidi S, Raymond M, Turcotte B, Sherlock G, Costanzo M, Ihmels J, Berman J, Sanglard D, Agabian N, Mitchell AP, Johnson AD, Whiteway M, Nantel A. A human-curated annotation of the Candida albicans genome. PLoS Genet. 2005 Jul; 1(1):36-57. PMID: 16103911; PMCID: PMC1183520.
    56. Kadosh D, Johnson AD. Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis. Mol Biol Cell. 2005 Jun; 16(6):2903-12. PMID: 15814840.
      View in: PubMed
    57. Green SR, Johnson AD. Genome-wide analysis of the functions of a conserved surface on the corepressor Tup1. Mol Biol Cell. 2005 Jun; 16(6):2605-13. PMID: 15788561.
      View in: PubMed
    58. Bennett RJ, Miller MG, Chua PR, Maxon ME, Johnson AD. Nuclear fusion occurs during mating in Candida albicans and is dependent on the KAR3 gene. Mol Microbiol. 2005 Feb; 55(4):1046-59. PMID: 15686553.
      View in: PubMed
    59. Noble SM, Johnson AD. Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell. 2005 Feb; 4(2):298-309. PMID: 15701792; PMCID: PMC549318.
    60. Galgoczy DJ, Cassidy-Stone A, Llinás M, O'Rourke SM, Herskowitz I, DeRisi JL, Johnson AD. Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18069-74. PMID: 15604142; PMCID: PMC535907.
    61. Green SR, Johnson AD. Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae. Mol Biol Cell. 2004 Sep; 15(9):4191-202. PMID: 15240822.
      View in: PubMed
    62. Tsong AE, Miller MG, Raisner RM, Johnson AD. Evolution of a combinatorial transcriptional circuit: a case study in yeasts. Cell. 2003 Nov 14; 115(4):389-99. PMID: 14622594.
      View in: PubMed
    63. Bennett RJ, Uhl MA, Miller MG, Johnson AD. Identification and characterization of a Candida albicans mating pheromone. Mol Cell Biol. 2003 Nov; 23(22):8189-201. PMID: 14585977; PMCID: PMC262406.
    64. Johnson A. The biology of mating in Candida albicans. Nat Rev Microbiol. 2003 Nov; 1(2):106-16. PMID: 15035040.
      View in: PubMed
    65. Uhl MA, Biery M, Craig N, Johnson AD. Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans. EMBO J. 2003 Jun 02; 22(11):2668-78. PMID: 12773383.
      View in: PubMed
    66. Bennett RJ, Johnson AD. Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J. 2003 May 15; 22(10):2505-15. PMID: 12743044; PMCID: PMC155993.
    67. Inglis DO, Johnson AD. Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans. Mol Cell Biol. 2002 Dec; 22(24):8669-80. PMID: 12446785; PMCID: PMC139894.
    68. Miller MG, Johnson AD. White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell. 2002 Aug 09; 110(3):293-302. PMID: 12176317.
      View in: PubMed