Soumaya Zlitni, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #1136C
San Francisco CA 94143
Emailsoumaya.zlitni@ucsf.edu
PronounsShe/Her/Hers
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    Trillions of microbes live on and inside our bodies, forming what can be described as an 'organ' that plays a critical role in health, physiology, and defense against pathogens. One of the major questions in this field is how microbes come together to form communities that perform essential functions for the host.
    The Zlitni lab integrates tools from microbiology, biochemistry, and advanced -omics technologies to investigate how microbial communication shapes both the assembly and function of the human microbiome. Beyond gaining fundamental insights into microbial communication, we aim to apply this knowledge toward developing live biotherapeutic interventions that restore microbiota resilience when it has been compromised.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of Enterococcus faecalis. bioRxiv. 2024 Aug 13. Zlitni S, Bowden S, Sberro H, Torres MDT, Vaughan JM, Pinto AFM, Pinto Y, Fernandez D, Röst H, Saghatelian A, de la Fuente-Nunez C, Bhatt AS. PMID: 39185165; PMCID: PMC11343167.
      View in: PubMed   Mentions:
    2. Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition. Cell. 2024 01 04; 187(1):62-78.e20. Gerrick ER, Zlitni S, West PT, Carter MM, Mechler CM, Olm MR, Caffrey EB, Li JA, Higginbottom SK, Severyn CJ, Kracke F, Spormann AM, Sonnenburg JL, Bhatt AS, Howitt MR. PMID: 38096822.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker. Appl Environ Microbiol. 2023 07 26; 89(7):e0058323. Natarajan A, Fremin BJ, Schmidtke DT, Wolfe MK, Zlitni S, Graham KE, Brooks EF, Severyn CJ, Sakamoto KM, Lacayo NJ, Kuersten S, Koble J, Caves G, Kaplan I, Singh U, Jagannathan P, Rezvani AR, Bhatt AS, Boehm AB. PMID: 37404180; PMCID: PMC10370318.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    4. Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker. bioRxiv. 2023 Jan 10. Natarajan A, Fremin BJ, Schmidtke DT, Wolfe MK, Zlitni S, Graham KE, Brooks EF, Severyn CJ, Sakamoto KM, Lacayo NJ, Kuersten S, Koble J, Caves G, Kaplan I, Singh U, Jagannathan P, Rezvani AR, Bhatt AS, Boehm AB. PMID: 36712100; PMCID: PMC9882089.
      View in: PubMed   Mentions:
    5. Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. Gut. 2023 03; 72(3):460-471. Anhê FF, Zlitni S, Zhang SY, Choi BS, Chen CY, Foley KP, Barra NG, Surette MG, Biertho L, Richard D, Tchernof A, Lam TKT, Marette A, Schertzer J. PMID: 36008102; PMCID: PMC9933168.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    6. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med. 2022 06 10; 3(6):371-387.e9. Natarajan A, Zlitni S, Brooks EF, Vance SE, Dahlen A, Hedlin H, Park RM, Han A, Schmidtke DT, Verma R, Jacobson KB, Parsonnet J, Bonilla HF, Singh U, Pinsky BA, Andrews JR, Jagannathan P, Bhatt AS. PMID: 35434682; PMCID: PMC9005383.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCells
    7. Life-long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents. Physiol Rep. 2022 03; 10(5):e15215. Anhê FF, Zlitni S, Barra NG, Foley KP, Nilsson MI, Nederveen JP, Koch LG, Britton SL, Tarnopolsky MA, Schertzer JD. PMID: 35246957; PMCID: PMC8897742.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Publisher Correction: Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nat Commun. 2021 Dec 01; 12(1):7100. Natarajan A, Han A, Zlitni S, Brooks EF, Vance SE, Wolfe M, Singh U, Jagannathan P, Pinsky BA, Boehm A, Bhatt AS. PMID: 34853336; PMCID: PMC8634246.
      View in: PubMed   Mentions: 2     Fields:    
    9. Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. Nat Commun. 2021 10 01; 12(1):5753. Natarajan A, Han A, Zlitni S, Brooks EF, Vance SE, Wolfe M, Singh U, Jagannathan P, Pinsky BA, Boehm A, Bhatt AS. PMID: 34599164; PMCID: PMC8486790.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    10. Standardized and optimized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA. medRxiv. 2021 Apr 17. Natarajan A, Han A, Zlitni S, Brooks EF, Vance SE, Wolfe M, Singh U, Jagannathan P, Pinsky BA, Boehm A, Bhatt AS. PMID: 33880485; PMCID: PMC8057253.
      View in: PubMed   Mentions:
    11. Gut microbiota impairs insulin clearance in obese mice. Mol Metab. 2020 12; 42:101067. Foley KP, Zlitni S, Duggan BM, Barra NG, Anhê FF, Cavallari JF, Henriksbo BD, Chen CY, Huang M, Lau TC, Plante R, Schwab M, Marette A, Schertzer JD. PMID: 32860984; PMCID: PMC7522491.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    12. Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required. Function (Oxf). 2020; 1(2):zqaa013. Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O'Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, Holloway GP. PMID: 34278304; PMCID: PMC8276887.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice. Am J Physiol Endocrinol Metab. 2020 08 01; 319(2):E305-E314. Cavallari JF, Pokrajac NT, Zlitni S, Foley KP, Henriksbo BD, Schertzer JD. PMID: 32516028.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Strain-resolved microbiome sequencing reveals mobile elements that drive bacterial competition on a clinical timescale. Genome Med. 2020 05 29; 12(1):50. Zlitni S, Bishara A, Moss EL, Tkachenko E, Kang JB, Culver RN, Andermann TM, Weng Z, Wood C, Handy C, Ji HP, Batzoglou S, Bhatt AS. PMID: 32471482; PMCID: PMC7260799.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    15. Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nat Microbiol. 2020 01; 5(1):93-101. Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED. PMID: 31659298.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes. Cell. 2019 08 22; 178(5):1245-1259.e14. Sberro H, Fremin BJ, Zlitni S, Edfors F, Greenfield N, Snyder MP, Pavlopoulos GA, Kyrpides NC, Bhatt AS. PMID: 31402174; PMCID: PMC6764417.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    17. Long term but not short term exposure to obesity related microbiota promotes host insulin resistance. Nat Commun. 2018 11 08; 9(1):4681. Foley KP, Zlitni S, Denou E, Duggan BM, Chan RW, Stearns JC, Schertzer JD. PMID: 30409977; PMCID: PMC6224578.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    18. An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia. Microbiology (Reading). 2015 Oct; 161(10):1909-1920. Bloodworth RAM, Zlitni S, Brown ED, Cardona ST. PMID: 26253539.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    19. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol. 2013 Dec; 9(12):796-804. Zlitni S, Ferruccio LF, Brown ED. PMID: 24121552; PMCID: PMC3970981.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    20. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorg Med Chem Lett. 2013 Apr 15; 23(8):2426-31. Barker CA, Allison SE, Zlitni S, Nguyen ND, Das R, Melacini G, Capretta AA, Brown ED. PMID: 23473681.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    21. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol. 2009 Nov; 5(11):849-56. Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. PMID: 19783991.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    22. Drug discovery: Not as fab as we thought. Nature. 2009 Mar 05; 458(7234):39-40. Zlitni S, Brown ED. PMID: 19262660.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. High-throughput screening of model bacteria. Methods Mol Biol. 2009; 486:13-27. Zlitni S, Blanchard JE, Brown ED. PMID: 19347613.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    24. Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. Am J Hum Genet. 2008 Dec; 83(6):684-91. Alazami AM, Al-Saif A, Al-Semari A, Bohlega S, Zlitni S, Alzahrani F, Bavi P, Kaya N, Colak D, Khalak H, Baltus A, Peterlin B, Danda S, Bhatia KP, Schneider SA, Sakati N, Walsh CA, Al-Mohanna F, Meyer B, Alkuraya FS. PMID: 19026396; PMCID: PMC2668059.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
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