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    Cynthia Darling, PhD

    Address707 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-5016
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kang H, Darling CL, Fried D. Use of an optical clearing agent to enhance the visibility of subsurface structures and lesions from tooth occlusal surfaces. J Biomed Opt. 2016 Aug 1; 21(8):81206. PMID: 27071709.
        View in: PubMed
      2. Simon JC, Lucas SA, Staninec M, Tom H, Chan KH, Darling CL, Cozin MJ, Lee RC, Fried D. Near-IR transillumination and reflectance imaging at 1,300?nm and 1,500-1,700?nm for in vivo caries detection. Lasers Surg Med. 2016 Nov; 48(9):828-836. PMID: 27389018.
        View in: PubMed
      3. Lee RC, Darling CL, Staninec M, Ragadio A, Fried D. Activity assessment of root caries lesions with thermal and near-IR imaging methods. J Biophotonics. 2016 Apr 6. PMID: 27060450.
        View in: PubMed
      4. Simon JC, Darling CL, Fried D. A system for simultaneous near-infrared reflectance and transillumination imaging of occlusal carious lesions. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006524.
        View in: PubMed
      5. Almaz EC, Simon JC, Fried D, Darling CL. Influence of stains on lesion contrast in the pits and fissures of tooth occlusal surfaces from 800-1600-nm. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997740.
        View in: PubMed
      6. Fried WA, Chan KH, Darling CL, Fried D. Selective removal of dental composite with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997741.
        View in: PubMed
      7. Yi I, Chan KH, Tsuji GH, Staninec M, Darling CL, Fried D. Selective removal of esthetic composite restorations with spectral guided laser ablation. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997742.
        View in: PubMed
      8. Lee RC, Darling CL, Fried D. Assessment of remineralized dentin lesions with thermal and near-infrared reflectance imaging. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006522.
        View in: PubMed
      9. Kang H, Darling CL, Fried D. Enhancement of OCT images with vinyl polysiloxane (VPS). Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27011417.
        View in: PubMed
      10. Simon JC, A Lucas S, Lee RC, Darling CL, Staninec M, Vaderhobli R, Pelzner R, Fried D. Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300-1700-nm. Dent Mater. 2016 Apr; 32(4):587-95. PMID: 26876234.
        View in: PubMed
      11. Tom H, Chan KH, Darling CL, Fried D. Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces. Lasers Surg Med. 2016 Jan; 48(1):52-61. PMID: 26763111.
        View in: PubMed
      12. Lee RC, Darling CL, Fried D. Assessment of remineralization via measurement of dehydration rates with thermal and near-IR reflectance imaging. J Dent. 2015 Aug; 43(8):1032-42. PMID: 25862275; PMCID: PMC4509858 [Available on 08/01/16].
      13. Chan KH, Tom H, Darling CL, Fried D. Serial removal of caries lesions from tooth occlusal surfaces using near-IR image-guided IR laser ablation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914499.
        View in: PubMed
      14. Chung LC, Tom H, Chan KH, Simon JC, Fried D, Darling CL. Image-guided removal of occlusal caries lesions with a ?= 9.3-µm CO2 laser using near-IR transillumination. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914498.
        View in: PubMed
      15. Yan R, Chan KH, Tom H, Simon JC, Darling CL, Fried D. Selective removal of dental caries with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914496.
        View in: PubMed
      16. Simon JC, Lucas S, Lee R, Darling CL, Staninec M, Vanderhobli R, Pelzner R, Fried D. In vitro near-infrared imaging of natural secondary caries. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914495.
        View in: PubMed
      17. Lee RC, Darling CL, Fried D. Assessment of remineralization in simulated enamel lesions via dehydration with near-IR reflectance imaging. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914494.
        View in: PubMed
      18. Kang H, Darling CL, Tom H, Fried D. Enhanced detection of dentinal lesions in OCT images using the RKT transformation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914493.
        View in: PubMed
      19. Chan KH, Tom H, Darling CL, Fried D. A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. Lasers Surg Med. 2014 Nov; 46(9):672-8. PMID: 25147133.
        View in: PubMed
      20. Lee RC, Kang H, Darling CL, Fried D. Automated assessment of the remineralization of artificial enamel lesions with polarization-sensitive optical coherence tomography. Biomed Opt Express. 2014 Sep 1; 5(9):2950-62. PMID: 25401009; PMCID: PMC4230881.
      21. Nee A, Chan K, Kang H, Staninec M, Darling CL, Fried D. Longitudinal monitoring of demineralization peripheral to orthodontic brackets using cross polarization optical coherence tomography. J Dent. 2014 May; 42(5):547-55. PMID: 24561340; PMCID: PMC4007269.
      22. Logan CM, Co KU, Fried WA, Simon JC, Staninec M, And DF, Darling CL. Multispectral Near-Infrared Imaging of Composite Restorations in Extracted Teeth. Proc SPIE Int Soc Opt Eng. 2014 Feb 20; 8929:89290R. PMID: 25309098.
        View in: PubMed
      23. Lee RC, Darling CL, Fried D. Automated detection of remineralization in simulated enamel lesions with PS-OCT. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290E. PMID: 25075267.
        View in: PubMed
      24. Chan AC, Darling CL, Chan KH, Fried D. Attenuation of near-IR light through dentin at wavelengths from 1300-1650-nm. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290M. PMID: 24839373.
        View in: PubMed
      25. Tom H, Chan KH, Darling CL, Fried D. Near-IR imaging of demineralization under sealants. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290S. PMID: 24817807.
        View in: PubMed
      26. Fried WA, Simon JC, Lucas S, Chan KH, Darling CL, Staninec M, Fried D. Near-IR imaging of cracks in teeth. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290Q. PMID: 24817806.
        View in: PubMed
      27. Kang H, Darling CL, Fried D. Enhancing the detection of hidden occlusal caries lesions with OCT using high index liquids. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290O. PMID: 24817805.
        View in: PubMed
      28. Simon JC, Lucas SA, Staninec M, Tom H, Chan KH, Darling CL, Fried D. Transillumination and reflectance probes for in vivo near-IR imaging of dental caries. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290D. PMID: 24817803.
        View in: PubMed
      29. Lamantia NR, Tom H, Chan KH, Simon JC, Darling CL, Fried D. High contrast optical imaging methods for image guided laser ablation of dental caries lesions. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929. PMID: 24791129.
        View in: PubMed
      30. Tom H, Simon JC, Chan KH, Darling CL, Fried D. Near-infrared imaging of demineralization under sealants. J Biomed Opt. 2014; 19(7):77003. PMID: 25036214; PMCID: PMC4103580.
      31. Simon JC, Chan KH, Darling CL, Fried D. Multispectral near-IR reflectance imaging of simulated early occlusal lesions: variation of lesion contrast with lesion depth and severity. Lasers Surg Med. 2014 Mar; 46(3):203-15. PMID: 24375543; PMCID: PMC3961544.
      32. Chan KH, Chan AC, Fried WA, Simon JC, Darling CL, Fried D. Use of 2D images of depth and integrated reflectivity to represent the severity of demineralization in cross-polarization optical coherence tomography. J Biophotonics. 2015 Jan; 8(1-2):36-45. PMID: 24307350.
        View in: PubMed
      33. Fried WA, Fried D, Chan KH, Darling CL. High contrast reflectance imaging of simulated lesions on tooth occlusal surfaces at near-IR wavelengths. Lasers Surg Med. 2013 Oct; 45(8):533-41. PMID: 23857066; PMCID: PMC4472445.
      34. Kang H, Chan K, Darling CL, Fried D. Monitoring the Remineralization of Early Simulated Lesions using a pH Cycling Model with CP-OCT. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353383.
        View in: PubMed
      35. Chan KH, Chan AC, Darling CL, Fried D. Methods for Monitoring Erosion Using Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566:856606. PMID: 24465117.
        View in: PubMed
      36. Fried WA, Fried D, Chan KH, Darling CL. Imaging Early Demineralization on Tooth Occlusal Surfaces with a High Definition InGaAs Camera. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24357911.
        View in: PubMed
      37. Fried D, Staninec M, Darling CL, Chan KH, Pelzner RB. Clinical Monitoring of Early Caries Lesions using Cross Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353384.
        View in: PubMed
      38. Kang H, Darling CL, Fried D. Nondestructive Monitoring of the Repair of Natural Occlusal Lesions using Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 23538837.
        View in: PubMed
      39. Darling CL, Staninec M, Chan KH, Kang H, Fried D. Remineralization of Root Caries Monitored Using Cross-Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 24357904.
        View in: PubMed
      40. Fried D, Staninec M, Darling C, Kang H, Chan K. Monitoring tooth demineralization using a cross polarization optical coherence tomographic system with an integrated MEMS scanner. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 24357905.
        View in: PubMed
      41. Kang H, Darling CL, Fried D. Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography. Dent Mater. 2012 May; 28(5):488-94. PMID: 22204914; PMCID: PMC3319335.
      42. Staninec M, Douglas SM, Darling CL, Chan K, Kang H, Lee RC, Fried D. Non-destructive clinical assessment of occlusal caries lesions using near-IR imaging methods. Lasers Surg Med. 2011 Dec; 43(10):951-9. PMID: 22109697; PMCID: PMC3241877.
      43. Chung S, Fried D, Staninec M, Darling CL. Multispectral near-IR reflectance and transillumination imaging of teeth. Biomed Opt Express. 2011 Oct 1; 2(10):2804-14. PMID: 22025986; PMCID: PMC3191447.
      44. Kang H, Darling CL, Fried D. Repair of Artificial Lesions using an Acidic Remineralization Model Monitored with Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840Q). PMID: 21785533.
        View in: PubMed
      45. Fried D, Staninec M, Darling CL, Lee C, Kang H, Chan KH. In vivo Near-IR Imaging of Occlusal Lesions at 1310-nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840B). PMID: 21785532.
        View in: PubMed
      46. Darling CL, Chan KH, Fried D. Polarization Resolved Near-IR Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2011 Jan 1; 7884. PMID: 22399837.
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      47. Chung S, Fried D, Staninec M, Darling CL. Near infrared imaging of teeth at wavelengths between 1200 and 1600 nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 1; 7884. PMID: 22399836.
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      48. Louie T, Lee C, Hsu D, Hirasuna K, Manesh S, Staninec M, Darling CL, Fried D. Clinical assessment of early tooth demineralization using polarization sensitive optical coherence tomography. Lasers Surg Med. 2010 Dec; 42(10):738-45. PMID: 21246578; PMCID: PMC3058417.
      49. Lee C, Lee D, Darling CL, Fried D. Nondestructive assessment of the severity of occlusal caries lesions with near-infrared imaging at 1310 nm. J Biomed Opt. 2010 Jul-Aug; 15(4):047011. PMID: 20799842; PMCID: PMC2929264.
      50. Kang H, Jiao JJ, Lee C, Le MH, Darling CL, Fried D. Nondestructive Assessment of Early Tooth Demineralization Using Cross-Polarization Optical Coherence Tomography. IEEE J Sel Top Quantum Electron. 2010 7; 16(4):870-876. PMID: 21660217.
        View in: PubMed
      51. Staninec M, Lee C, Darling CL, Fried D. In vivo near-IR imaging of approximal dental decay at 1,310 nm. Lasers Surg Med. 2010 Apr; 42(4):292-8. PMID: 20432277; PMCID: PMC3195334.
      52. Lee C, Darling CL, Fried D. In vitro near-infrared imaging of occlusal dental caries using germanium enhanced CMOS camera. Proc SPIE Int Soc Opt Eng. 2010 Mar 1; 7549. PMID: 22162916.
        View in: PubMed
      53. Kang H, Jiao JJ, Lee C, Darling CL, Fried D. Imaging early demineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2010 Jan 1; 7549. PMID: 22399835.
        View in: PubMed
      54. Douglas SM, Fried D, Darling CL. Imaging Natural Occlusal Caries Lesions with Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490N. PMID: 22228981.
        View in: PubMed
      55. Darling CL, Jiao JJ, Lee C, Kang H, Fried D. Near-IR Polarization Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490L. PMID: 22228980.
        View in: PubMed
      56. Le MH, Darling CL, Fried D. Automated analysis of lesion depth and integrated reflectivity in PS-OCT scans of tooth demineralization. Lasers Surg Med. 2010 Jan; 42(1):62-8. PMID: 20077486; PMCID: PMC3192502.
      57. Manesh SK, Darling CL, Fried D. Nondestructive assessment of dentin demineralization using polarization-sensitive optical coherence tomography after exposure to fluoride and laser irradiation. J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):802-12. PMID: 19283826; PMCID: PMC2707504.
      58. Manesh SK, Darling CL, Fried D. Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin. J Biomed Opt. 2009 Jul-Aug; 14(4):044002. PMID: 19725714.
        View in: PubMed
      59. Staninec M, Darling CL, Goodis HE, Pierre D, Cox DP, Fan K, Larson M, Parisi R, Hsu D, Manesh SK, Ho C, Hosseini M, Fried D. Pulpal effects of enamel ablation with a microsecond pulsed lambda = 9.3-microm CO2 laser. Lasers Surg Med. 2009 Apr; 41(4):256-63. PMID: 19347946; PMCID: PMC3188421.
      60. Lee C, Hsu DJ, Le MH, Darling CL, Fried D. Non-destructive measurement of demineralization & remineralization in the occlusal pits and fissures of extracted 3 molars with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Mar 6; 7162(1). PMID: 21935289.
        View in: PubMed
      61. Le MH, Darling CL, Fried D. Methods for calculating the severity of demineralization on tooth surfaces from PS-OCT scans. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935290.
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      62. Darling CL, Le CQ, Featherstone JD, Fried D. An Automated Digital Microradiography System for Assessing Tooth Demineralization. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935288.
        View in: PubMed
      63. Lee C, Darling CL, Fried D. Polarization-sensitive optical coherence tomographic imaging of artificial demineralization on exposed surfaces of tooth roots. Dent Mater. 2009 Jun; 25(6):721-8. PMID: 19167052; PMCID: PMC2701248.
      64. Lee D, Fried D, Darling CL. Near-IR Multi-modal Imaging of Natural Occlusal Lesions. Proc SPIE Int Soc Opt Eng. 2009; 7162:71620X. PMID: 22228979.
        View in: PubMed
      65. Manesh SK, Darling CL, Fried D. Assessment of Dentin Remineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Jan 1; 7162. PMID: 21998493.
        View in: PubMed
      66. Pugach MK, Strother J, Darling CL, Fried D, Gansky SA, Marshall SJ, Marshall GW. Dentin caries zones: mineral, structure, and properties. J Dent Res. 2009 Jan; 88(1):71-6. PMID: 19131321; PMCID: PMC2759645.
      67. Hsu DJ, Darling CL, Lachica MM, Fried D. Nondestructive assessment of the inhibition of enamel demineralization by CO2 laser treatment using polarization sensitive optical coherence tomography. J Biomed Opt. 2008 Sep-Oct; 13(5):054027. PMID: 19021407.
        View in: PubMed
      68. Can AM, Darling CL, Ho C, Fried D. Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a lambda=9.3-microm CO2 laser at ablative irradiation intensities with PS-OCT. Lasers Surg Med. 2008 Jul; 40(5):342-9. PMID: 18563781.
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      69. Hirasuna K, Fried D, Darling CL. Near-infrared imaging of developmental defects in dental enamel. J Biomed Opt. 2008 Jul-Aug; 13(4):044011. PMID: 19021339.
        View in: PubMed
      70. Can AM, Darling CL, Fried D. High-resolution PS-OCT of Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430T1-68430T7. PMID: 21909226.
        View in: PubMed
      71. Hsu DJ, Darling CL, Fried D. Imaging laser irradiated enamel surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:8430N-N8430. PMID: 21909224.
        View in: PubMed
      72. Darling CL, Fried D. Real-time near IR (1310 nm) imaging of CO2 laser ablation of enamel. Opt Express. 2008 Feb 18; 16(4):2685-93. PMID: 18542353.
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      73. Darling CL, Maffei ME, Fried WA, Fried D. Near-IR imaging of Erbium Laser Ablation with a Water Spray. Proc SPIE Int Soc Opt Eng. 2008 Jan 20; 6843(684303). PMID: 21892255.
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      74. Manesh SK, Darling CL, Fried D. Imaging natural and artificial demineralization on dentin surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Jan 1; 6843. PMID: 21998492.
        View in: PubMed
      75. Chong SL, Darling CL, Fried D. Nondestructive measurement of the inhibition of demineralization on smooth surfaces using polarization-sensitive optical coherence tomography. Lasers Surg Med. 2007 Jun; 39(5):422-7. PMID: 17565731.
        View in: PubMed
      76. Darling CL, Huynh GD, Fried D. Light scattering properties of natural and artificially demineralized dental enamel at 1310 nm. J Biomed Opt. 2006 May-Jun; 11(3):34023. PMID: 16822072.
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      77. Jones RS, Darling CL, Featherstone JD, Fried D. Imaging artificial caries on the occlusal surfaces with polarization-sensitive optical coherence tomography. Caries Res. 2006; 40(2):81-9. PMID: 16508263.
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      78. Jones RS, Darling CL, Featherstone JD, Fried D. Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography. J Biomed Opt. 2006 Jan-Feb; 11(1):014016. PMID: 16526893.
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      79. Fried D, Featherstone JD, Darling CL, Jones RS, Ngaotheppitak P, Bühler CM. Early caries imaging and monitoring with near-infrared light. Dent Clin North Am. 2005 Oct; 49(4):771-93, vi. PMID: 16150316.
        View in: PubMed
      80. Ngaotheppitak P, Darling CL, Fried D. Measurement of the severity of natural smooth surface (interproximal) caries lesions with polarization sensitive optical coherence tomography. Lasers Surg Med. 2005 Jul; 37(1):78-88. PMID: 15889402.
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