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Cynthia Darling, PhD

TitleProfessor
SchoolUCSF School of Dentistry
DepartmentPreventive & Restor Dent Sci
Address707 Parnassus Ave
San Francisco CA 94143
Phone415-476-5016
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee RC, Darling C, Staninec M, Ragadio A, Fried D. Activity assessment of root caries lesions with thermal and near-IR imaging methods. J Biophotonics. 2016 Apr 6. PMID: 27060450.
      View in: PubMed
    2. Simon JC, Darling C, Fried D. A system for simultaneous near-infrared reflectance and transillumination imaging of occlusal carious lesions. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006524.
      View in: PubMed
    3. Almaz EC, Simon JC, Fried D, Darling C. Influence of stains on lesion contrast in the pits and fissures of tooth occlusal surfaces from 800-1600-nm. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997740.
      View in: PubMed
    4. Fried WA, Chan KH, Darling C, Fried D. Selective removal of dental composite with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997741.
      View in: PubMed
    5. Yi I, Chan KH, Tsuji GH, Staninec M, Darling C, Fried D. Selective removal of esthetic composite restorations with spectral guided laser ablation. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997742.
      View in: PubMed
    6. Lee RC, Darling C, Fried D. Assessment of remineralized dentin lesions with thermal and near-infrared reflectance imaging. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006522.
      View in: PubMed
    7. Kang H, Darling C, Fried D. Enhancement of OCT images with vinyl polysiloxane (VPS). Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27011417.
      View in: PubMed
    8. Simon JC, A Lucas S, Lee RC, Darling C, Staninec M, Vaderhobli R, Pelzner R, Fried D. Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300-1700-nm. Dent Mater. 2016 Apr; 32(4):587-95. PMID: 26876234.
      View in: PubMed
    9. Tom H, Chan KH, Darling C, Fried D. Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces. Lasers Surg Med. 2016 Jan; 48(1):52-61. PMID: 26763111.
      View in: PubMed
    10. Lee RC, Darling C, Fried D. Assessment of remineralization via measurement of dehydration rates with thermal and near-IR reflectance imaging. J Dent. 2015 Aug; 43(8):1032-42. PMID: 25862275; PMCID: PMC4509858 [Available on 08/01/16].
    11. Chan KH, Tom H, Darling C, Fried D. Serial removal of caries lesions from tooth occlusal surfaces using near-IR image-guided IR laser ablation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914499.
      View in: PubMed
    12. Chung LC, Tom H, Chan KH, Simon JC, Fried D, Darling C. Image-guided removal of occlusal caries lesions with a ?= 9.3-µm CO2 laser using near-IR transillumination. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914498.
      View in: PubMed
    13. Yan R, Chan KH, Tom H, Simon JC, Darling C, Fried D. Selective removal of dental caries with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914496.
      View in: PubMed
    14. Simon JC, Lucas S, Lee R, Darling C, Staninec M, Vanderhobli R, Pelzner R, Fried D. In vitro near-infrared imaging of natural secondary caries. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914495.
      View in: PubMed
    15. Lee RC, Darling C, Fried D. Assessment of remineralization in simulated enamel lesions via dehydration with near-IR reflectance imaging. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914494.
      View in: PubMed
    16. Kang H, Darling C, Tom H, Fried D. Enhanced detection of dentinal lesions in OCT images using the RKT transformation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914493.
      View in: PubMed
    17. Chan KH, Tom H, Darling C, Fried D. A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. Lasers Surg Med. 2014 Nov; 46(9):672-8. PMID: 25147133.
      View in: PubMed
    18. Lee RC, Kang H, Darling C, Fried D. Automated assessment of the remineralization of artificial enamel lesions with polarization-sensitive optical coherence tomography. Biomed Opt Express. 2014 Sep 1; 5(9):2950-62. PMID: 25401009; PMCID: PMC4230881.
    19. Nee A, Chan K, Kang H, Staninec M, Darling C, Fried D. Longitudinal monitoring of demineralization peripheral to orthodontic brackets using cross polarization optical coherence tomography. J Dent. 2014 May; 42(5):547-55. PMID: 24561340; PMCID: PMC4007269.
    20. Logan CM, Co KU, Fried WA, Simon JC, Staninec M, And DF, Darling C. Multispectral Near-Infrared Imaging of Composite Restorations in Extracted Teeth. Proc SPIE Int Soc Opt Eng. 2014 Feb 20; 8929:89290R. PMID: 25309098.
      View in: PubMed
    21. Lee RC, Darling C, Fried D. Automated detection of remineralization in simulated enamel lesions with PS-OCT. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290E. PMID: 25075267.
      View in: PubMed
    22. Chan AC, Darling C, Chan KH, Fried D. Attenuation of near-IR light through dentin at wavelengths from 1300-1650-nm. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290M. PMID: 24839373.
      View in: PubMed
    23. Tom H, Chan KH, Darling C, Fried D. Near-IR imaging of demineralization under sealants. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290S. PMID: 24817807.
      View in: PubMed
    24. Fried WA, Simon JC, Lucas S, Chan KH, Darling C, Staninec M, Fried D. Near-IR imaging of cracks in teeth. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290Q. PMID: 24817806.
      View in: PubMed
    25. Kang H, Darling C, Fried D. Enhancing the detection of hidden occlusal caries lesions with OCT using high index liquids. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290O. PMID: 24817805.
      View in: PubMed
    26. Simon JC, Lucas SA, Staninec M, Tom H, Chan KH, Darling C, Fried D. Transillumination and reflectance probes for in vivo near-IR imaging of dental caries. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290D. PMID: 24817803.
      View in: PubMed
    27. Lamantia NR, Tom H, Chan KH, Simon JC, Darling C, Fried D. High contrast optical imaging methods for image guided laser ablation of dental caries lesions. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929. PMID: 24791129.
      View in: PubMed
    28. Tom H, Simon JC, Chan KH, Darling C, Fried D. Near-infrared imaging of demineralization under sealants. J Biomed Opt. 2014; 19(7):77003. PMID: 25036214; PMCID: PMC4103580.
    29. Simon JC, Chan KH, Darling C, Fried D. Multispectral near-IR reflectance imaging of simulated early occlusal lesions: variation of lesion contrast with lesion depth and severity. Lasers Surg Med. 2014 Mar; 46(3):203-15. PMID: 24375543; PMCID: PMC3961544.
    30. Chan KH, Chan AC, Fried WA, Simon JC, Darling C, Fried D. Use of 2D images of depth and integrated reflectivity to represent the severity of demineralization in cross-polarization optical coherence tomography. J Biophotonics. 2015 Jan; 8(1-2):36-45. PMID: 24307350.
      View in: PubMed
    31. Fried WA, Fried D, Chan KH, Darling C. High contrast reflectance imaging of simulated lesions on tooth occlusal surfaces at near-IR wavelengths. Lasers Surg Med. 2013 Oct; 45(8):533-41. PMID: 23857066; PMCID: PMC4472445.
    32. Chan KH, Chan AC, Darling C, Fried D. Methods for Monitoring Erosion Using Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566:856606. PMID: 24465117.
      View in: PubMed
    33. Fried WA, Fried D, Chan KH, Darling C. Imaging Early Demineralization on Tooth Occlusal Surfaces with a High Definition InGaAs Camera. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24357911.
      View in: PubMed
    34. Fried D, Staninec M, Darling C, Chan KH, Pelzner RB. Clinical Monitoring of Early Caries Lesions using Cross Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353384.
      View in: PubMed
    35. Kang H, Chan K, Darling C, Fried D. Monitoring the Remineralization of Early Simulated Lesions using a pH Cycling Model with CP-OCT. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353383.
      View in: PubMed
    36. Kang H, Darling C, Fried D. Nondestructive Monitoring of the Repair of Natural Occlusal Lesions using Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 23538837.
      View in: PubMed
    37. Darling C, Staninec M, Chan KH, Kang H, Fried D. Remineralization of Root Caries Monitored Using Cross-Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 24357904.
      View in: PubMed
    38. Fried D, Staninec M, Darling C, Kang H, Chan K. Monitoring tooth demineralization using a cross polarization optical coherence tomographic system with an integrated MEMS scanner. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8208. PMID: 24357905.
      View in: PubMed
    39. Kang H, Darling C, Fried D. Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography. Dent Mater. 2012 May; 28(5):488-94. PMID: 22204914; PMCID: PMC3319335.
    40. Staninec M, Douglas SM, Darling C, Chan K, Kang H, Lee RC, Fried D. Non-destructive clinical assessment of occlusal caries lesions using near-IR imaging methods. Lasers Surg Med. 2011 Dec; 43(10):951-9. PMID: 22109697; PMCID: PMC3241877.
    41. Chung S, Fried D, Staninec M, Darling C. Multispectral near-IR reflectance and transillumination imaging of teeth. Biomed Opt Express. 2011 Oct 1; 2(10):2804-14. PMID: 22025986; PMCID: PMC3191447.
    42. Kang H, Darling C, Fried D. Repair of Artificial Lesions using an Acidic Remineralization Model Monitored with Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840Q). PMID: 21785533.
      View in: PubMed
    43. Fried D, Staninec M, Darling C, Lee C, Kang H, Chan KH. In vivo Near-IR Imaging of Occlusal Lesions at 1310-nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840B). PMID: 21785532.
      View in: PubMed
    44. Darling C, Chan KH, Fried D. Polarization Resolved Near-IR Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2011 Jan 1; 7884. PMID: 22399837.
      View in: PubMed
    45. Chung S, Fried D, Staninec M, Darling C. Near infrared imaging of teeth at wavelengths between 1200 and 1600 nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 1; 7884. PMID: 22399836.
      View in: PubMed
    46. Louie T, Lee C, Hsu D, Hirasuna K, Manesh S, Staninec M, Darling C, Fried D. Clinical assessment of early tooth demineralization using polarization sensitive optical coherence tomography. Lasers Surg Med. 2010 Dec; 42(10):738-45. PMID: 21246578; PMCID: PMC3058417.
    47. Lee C, Lee D, Darling C, Fried D. Nondestructive assessment of the severity of occlusal caries lesions with near-infrared imaging at 1310 nm. J Biomed Opt. 2010 Jul-Aug; 15(4):047011. PMID: 20799842; PMCID: PMC2929264.
    48. Kang H, Jiao JJ, Lee C, Le MH, Darling C, Fried D. Nondestructive Assessment of Early Tooth Demineralization Using Cross-Polarization Optical Coherence Tomography. IEEE J Sel Top Quantum Electron. 2010 7; 16(4):870-876. PMID: 21660217.
      View in: PubMed
    49. Staninec M, Lee C, Darling C, Fried D. In vivo near-IR imaging of approximal dental decay at 1,310 nm. Lasers Surg Med. 2010 Apr; 42(4):292-8. PMID: 20432277; PMCID: PMC3195334.
    50. Lee C, Darling C, Fried D. In vitro near-infrared imaging of occlusal dental caries using germanium enhanced CMOS camera. Proc SPIE Int Soc Opt Eng. 2010 Mar 1; 7549. PMID: 22162916.
      View in: PubMed
    51. Kang H, Jiao JJ, Lee C, Darling C, Fried D. Imaging early demineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2010 Jan 1; 7549. PMID: 22399835.
      View in: PubMed
    52. Douglas SM, Fried D, Darling C. Imaging Natural Occlusal Caries Lesions with Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490N. PMID: 22228981.
      View in: PubMed
    53. Darling C, Jiao JJ, Lee C, Kang H, Fried D. Near-IR Polarization Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490L. PMID: 22228980.
      View in: PubMed
    54. Le MH, Darling C, Fried D. Automated analysis of lesion depth and integrated reflectivity in PS-OCT scans of tooth demineralization. Lasers Surg Med. 2010 Jan; 42(1):62-8. PMID: 20077486; PMCID: PMC3192502.
    55. Manesh SK, Darling C, Fried D. Nondestructive assessment of dentin demineralization using polarization-sensitive optical coherence tomography after exposure to fluoride and laser irradiation. J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):802-12. PMID: 19283826; PMCID: PMC2707504.
    56. Manesh SK, Darling C, Fried D. Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin. J Biomed Opt. 2009 Jul-Aug; 14(4):044002. PMID: 19725714.
      View in: PubMed
    57. Staninec M, Darling C, Goodis HE, Pierre D, Cox DP, Fan K, Larson M, Parisi R, Hsu D, Manesh SK, Ho C, Hosseini M, Fried D. Pulpal effects of enamel ablation with a microsecond pulsed lambda = 9.3-microm CO2 laser. Lasers Surg Med. 2009 Apr; 41(4):256-63. PMID: 19347946; PMCID: PMC3188421.
    58. Lee C, Hsu DJ, Le MH, Darling C, Fried D. Non-destructive measurement of demineralization & remineralization in the occlusal pits and fissures of extracted 3 molars with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Mar 6; 7162(1). PMID: 21935289.
      View in: PubMed
    59. Le MH, Darling C, Fried D. Methods for calculating the severity of demineralization on tooth surfaces from PS-OCT scans. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935290.
      View in: PubMed
    60. Darling C, Le CQ, Featherstone JD, Fried D. An Automated Digital Microradiography System for Assessing Tooth Demineralization. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935288.
      View in: PubMed
    61. Lee C, Darling C, Fried D. Polarization-sensitive optical coherence tomographic imaging of artificial demineralization on exposed surfaces of tooth roots. Dent Mater. 2009 Jun; 25(6):721-8. PMID: 19167052; PMCID: PMC2701248.
    62. Pugach MK, Strother J, Darling C, Fried D, Gansky SA, Marshall SJ, Marshall GW. Dentin caries zones: mineral, structure, and properties. J Dent Res. 2009 Jan; 88(1):71-6. PMID: 19131321; PMCID: PMC2759645.
    63. Lee D, Fried D, Darling C. Near-IR Multi-modal Imaging of Natural Occlusal Lesions. Proc SPIE Int Soc Opt Eng. 2009; 7162:71620X. PMID: 22228979.
      View in: PubMed
    64. Manesh SK, Darling C, Fried D. Assessment of Dentin Remineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Jan 1; 7162. PMID: 21998493.
      View in: PubMed
    65. Hsu DJ, Darling C, Lachica MM, Fried D. Nondestructive assessment of the inhibition of enamel demineralization by CO2 laser treatment using polarization sensitive optical coherence tomography. J Biomed Opt. 2008 Sep-Oct; 13(5):054027. PMID: 19021407.
      View in: PubMed
    66. Hirasuna K, Fried D, Darling C. Near-infrared imaging of developmental defects in dental enamel. J Biomed Opt. 2008 Jul-Aug; 13(4):044011. PMID: 19021339.
      View in: PubMed
    67. Can AM, Darling C, Ho C, Fried D. Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a lambda=9.3-microm CO2 laser at ablative irradiation intensities with PS-OCT. Lasers Surg Med. 2008 Jul; 40(5):342-9. PMID: 18563781.
      View in: PubMed
    68. Can AM, Darling C, Fried D. High-resolution PS-OCT of Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430T1-68430T7. PMID: 21909226.
      View in: PubMed
    69. Hsu DJ, Darling C, Fried D. Imaging laser irradiated enamel surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:8430N-N8430. PMID: 21909224.
      View in: PubMed
    70. Darling C, Fried D. Real-time near IR (1310 nm) imaging of CO2 laser ablation of enamel. Opt Express. 2008 Feb 18; 16(4):2685-93. PMID: 18542353.
      View in: PubMed
    71. Darling C, Maffei ME, Fried WA, Fried D. Near-IR imaging of Erbium Laser Ablation with a Water Spray. Proc SPIE Int Soc Opt Eng. 2008 Jan 20; 6843(684303). PMID: 21892255.
      View in: PubMed
    72. Manesh SK, Darling C, Fried D. Imaging natural and artificial demineralization on dentin surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Jan 1; 6843. PMID: 21998492.
      View in: PubMed
    73. Chong SL, Darling C, Fried D. Nondestructive measurement of the inhibition of demineralization on smooth surfaces using polarization-sensitive optical coherence tomography. Lasers Surg Med. 2007 Jun; 39(5):422-7. PMID: 17565731.
      View in: PubMed
    74. Darling C, Huynh GD, Fried D. Light scattering properties of natural and artificially demineralized dental enamel at 1310 nm. J Biomed Opt. 2006 May-Jun; 11(3):34023. PMID: 16822072.
      View in: PubMed
    75. Jones RS, Darling C, Featherstone JD, Fried D. Imaging artificial caries on the occlusal surfaces with polarization-sensitive optical coherence tomography. Caries Res. 2006; 40(2):81-9. PMID: 16508263.
      View in: PubMed
    76. Jones RS, Darling C, Featherstone JD, Fried D. Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography. J Biomed Opt. 2006 Jan-Feb; 11(1):014016. PMID: 16526893.
      View in: PubMed
    77. Fried D, Featherstone JD, Darling C, Jones RS, Ngaotheppitak P, Bühler CM. Early caries imaging and monitoring with near-infrared light. Dent Clin North Am. 2005 Oct; 49(4):771-93, vi. PMID: 16150316.
      View in: PubMed
    78. Ngaotheppitak P, Darling C, Fried D. Measurement of the severity of natural smooth surface (interproximal) caries lesions with polarization sensitive optical coherence tomography. Lasers Surg Med. 2005 Jul; 37(1):78-88. PMID: 15889402.
      View in: PubMed
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