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Daniel Fried, PhD

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
Phone415-502-6641
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    Collapse Research 
    Collapse Research Activities and Funding
    Imaging Dental Caries with SWIR Light
    NIH/NIDCR R01DE028295Aug 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Optical Methods for Lesion Activity Assessment
    NIH/NIDCR R01DE027335Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Selective Ablation of Dental Caries and Composites
    NIH/NIDCR R01DE019631Sep 1, 2009 - Mar 31, 2018
    Role: Principal Investigator
    Clinical Assessment of Tooth Demineralization &Remineralization with PS-OCT
    NIH/NIDCR R01DE017869Aug 15, 2006 - Jul 31, 2015
    Role: Principal Investigator
    Early Caries Detection with Near-IR Light
    NIH/NIDCR R01DE014698Aug 1, 2002 - May 31, 2006
    Role: Principal Investigator
    Laser Ablation of Dental Hard Tissues
    NIH/NIDCR R01DE014554Jun 1, 2002 - May 31, 2008
    Role: Principal Investigator
    MULTIPURPOSE CO2 TEA LASER FOR DENTAL APPLICATIONS
    NIH/NIDCR R41DE012971Aug 1, 2000 - Jul 31, 2001
    Role: Principal Investigator
    IR LASER ABLATION OF DENTAL HARD TISSUE
    NIH/NIDCR R29DE012091Aug 1, 1997 - May 31, 2003
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fried WA, Zhu Y, Yang V, Chang NY, Fried D. A SWIR imaging handpiece for the clinical assessment of lesion activity via dehydration. Preclinical Assessment. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. PMID: 32194294.
      View in: PubMed
    2. Simon JC, Choi JH, Jang A, Fried D. In vivo spectral guided removal of composite from tooth surfaces with a CO2 laser. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. PMID: 32161428.
      View in: PubMed
    3. Yang VB, Chang NY, Fried D. A thermal imaging handpiece for the clinical assessment of lesion activity on root surfaces via dehydration. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. PMID: 32231402.
      View in: PubMed
    4. Abdelaziz M, Krejci I, Fried D. Enhancing the detection of proximal cavities on near infrared transillumination images with Indocyanine Green (ICG) as a contrast medium: In vitro proof of concept studies. J Dent. 2019 Dec; 91:103222. PMID: 31682898.
      View in: PubMed
    5. Yang V, Fried D. Measurement of the shrinkage of natural and simulated lesions on root surfaces using CP-OCT. J Dent. 2019 Nov; 90:103213. PMID: 31622647.
      View in: PubMed
    6. Alghilan MA, Lippert F, Platt JA, Eckert GJ, González-Cabezas C, Fried D, Hara AT. In vitro longitudinal evaluation of enamel wear by cross-polarization optical coherence tomography. Dent Mater. 2019 10; 35(10):1464-1470. PMID: 31395451.
      View in: PubMed
    7. Fried WA, Chan KH, Darling CL, Curtis DA, Fried D. Image-Guided Ablation of Dental Calculus From Root Surfaces Using a DPSS Er:YAG Laser. Lasers Surg Med. 2020 Mar; 52(3):247-258. PMID: 31236996.
      View in: PubMed
    8. Ng C, Almaz E, Simon J, Fried D, Darling C. Near-infrared imaging of demineralization on the occlusal surfaces of teeth without the interference of stains. J Biomed Opt. 2019 03; 24(3):1-8. PMID: 30834721.
      View in: PubMed
    9. Chang NN, Abdelaziz M, Fried D. The Relationship of Dehydration Rate and Transparent Surface Layer Thickness for Coronal Lesions on Extracted Teeth. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. PMID: 30918416.
      View in: PubMed
    10. Yang VB, Fried D. An appliance for monitoring the shrinkage of root caries with OCT. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. PMID: 30918417.
      View in: PubMed
    11. Fried WA, Chan KH, Darling CL, Fried D. Selective removal of dental calculus with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. PMID: 31000908.
      View in: PubMed
    12. Mohajerani N, Chan KH, Yang VB, Fried D, Darling CL. The contrast of demineralization on tooth occlusal surfaces from 405 to 1950-nm with varying depth. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. PMID: 30923417.
      View in: PubMed
    13. Dhillon N, Chan KH, Yang VB, Fried D. Image guided laser ablation of demineralization from root surfaces. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. PMID: 31007338.
      View in: PubMed
    14. Alghilan MA, Lippert F, Platt JA, Eckert GJ, González-Cabezas C, Fried D, Hara AT. Impact of surface micromorphology and demineralization severity on enamel loss measurements by cross-polarization optical coherence tomography. J Dent. 2019 02; 81:52-58. PMID: 30582963.
      View in: PubMed
    15. Fried WA, Chan KH, Darling CL, Fried D. Use of a DPSS Er:YAG laser for the selective removal of composite from tooth surfaces. Biomed Opt Express. 2018 Oct 01; 9(10):5026-5036. PMID: 30319919.
      View in: PubMed
    16. Chan KH, Fried D. Selective ablation of dental caries using coaxial Co2 (9.3-µm) and near-IR (1880-nm) lasers. Lasers Surg Med. 2019 02; 51(2):176-184. PMID: 30024032.
      View in: PubMed
    17. Yang VB, Curtis DA, Fried D. Cross-polarization reflectance imaging of root caries and dental calculus on extracted teeth at wavelengths from 400 to 2350 nm. J Biophotonics. 2018 11; 11(11):e201800113. PMID: 29952066.
      View in: PubMed
    18. Katkar RA, Tadinada SA, Amaechi BT, Fried D. Optical Coherence Tomography. Dent Clin North Am. 2018 Jul; 62(3):421-434. PMID: 29903559.
      View in: PubMed
    19. Amaechi BT, Owosho AA, Fried D. Fluorescence and Near-Infrared Light Transillumination. Dent Clin North Am. 2018 Jul; 62(3):435-452. PMID: 29903560.
      View in: PubMed
    20. Chan KH, Fried D. Multispectral cross-polarization reflectance measurements suggest high contrast of demineralization on tooth surfaces at wavelengths beyond 1300 nm due to reduced light scattering in sound enamel. J Biomed Opt. 2018 06; 23(6):1-4. PMID: 29877068.
      View in: PubMed
    21. Simon JC, Curtis DA, Darling CL, Fried D. Multispectral near-infrared reflectance and transillumination imaging of occlusal carious lesions: Variation in lesion contrast with lesion depth. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. PMID: 29497229.
      View in: PubMed
    22. Ngo A, Chan KH, Le O, Simon JC, Fried D. Image-guided Removal of Interproximal Lesions with a CO2 Laser. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. PMID: 29497230.
      View in: PubMed
    23. Ng C, Simon JC, Fried D, Darling CL. SWIR reflectance imaging of demineralization on the occlusal surfaces of teeth beyond 1700 nm. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. PMID: 30686852.
      View in: PubMed
    24. Chang NN, Jew JM, Fried D. Lesion Dehydration Rate Changes with the Surface Layer Thickness during Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2018 Feb; 10473. PMID: 30034077.
      View in: PubMed
    25. Chan KH, Fried NM, Fried D. Selective Ablation of Carious Lesions using an Integrated Near-IR Imaging System and a Novel 9.3-µm CO2 Laser. Proc SPIE Int Soc Opt Eng. 2018 Feb; 10473. PMID: 30034078.
      View in: PubMed
    26. Chang NN, Jew JM, Simon JC, Chen KH, Lee RC, Fried WA, Cho J, Darling CL, Fried D. Influence of multi-wavelength laser irradiation of enamel and dentin surfaces at 0.355, 2.94, and 9.4?µm on surface morphology, permeability, and acid resistance. Lasers Surg Med. 2017 12; 49(10):913-927. PMID: 28699676.
      View in: PubMed
    27. Jang AT, Chan KH, Fried D. Automated ablation of dental composite using an IR pulsed laser coupled to a plume emission spectral feedback system. Lasers Surg Med. 2017 09; 49(7):658-665. PMID: 28467687.
      View in: PubMed
    28. Simon JC, Kang H, Staninec M, Jang AT, Chan KH, Darling CL, Lee RC, Fried D. Near-IR and CP-OCT imaging of suspected occlusal caries lesions. Lasers Surg Med. 2017 03; 49(3):215-224. PMID: 28339115.
      View in: PubMed
    29. Kim JW, Lee R, Chan KH, Jew JM, Fried D. Influence of a pulsed CO2 laser operating at 9.4??µm on the surface morphology, reflectivity, and acid resistance of dental enamel below the threshold for melting. J Biomed Opt. 2017 02 01; 22(2):28001. PMID: 28145558.
      View in: PubMed
    30. Berg RA, Simon JC, Fried D, Darling CL. Optical changes of dentin in the near-IR as a function of mineral content. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28450756.
      View in: PubMed
    31. Jang AT, Chan KH, Fried D. Automated ablation of dental composite using an IR pulsed laser coupled to a plume emission spectral feedback system. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28479654.
      View in: PubMed
    32. Fried WA, Simon JC, Darling CL, Le O, Fried D. High-Contrast Reflectance Imaging of Composite Restorations Color-Matched to Tooth Structure at 1000-2300-nm. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626287.
      View in: PubMed
    33. Chang NN, Jew J, Simon JC, Chan KH, Lee RC, Fried WA, Cho J, Darling CL, Fried D. Influence of Multi-Wavelength Laser Irradiation of Enamel and Dentin Surfaces on Surface Morphology and Permeability. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28680191.
      View in: PubMed
    34. Simon JC, Darling CL, Fried D. Assessment of cavitation in artificial approximal dental lesions with near-IR imaging. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626283.
      View in: PubMed
    35. Lee RC, Jang A, Fried D. Near-infrared imaging of enamel hypomineralization due to developmental defects. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626284.
      View in: PubMed
    36. Chan KH, Fried D. Selective Laser Ablation of Carious Lesions using Simultaneous Scanned Near-IR Diode and CO2 Lasers. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626285.
      View in: PubMed
    37. Lee R, Chan KH, Jew J, Simon JC, Fried D. Synergistic effect of fluoride and laser irradiation for the inhibition of the demineralization of dental enamel. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626286.
      View in: PubMed
    38. Cho H, Lee RC, Chan KH, Fried D. Assessment of radicular dentin permeability after irradiation with CO2 laser and endodontic irrigation treatments with thermal imaging. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28626288.
      View in: PubMed
    39. Jew J, Chan KH, Darling CL, Fried D. Selective removal of natural caries lesions from dentin and tooth occlusal surfaces using a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. PMID: 28450757.
      View in: PubMed
    40. Kang H, Darling CL, Fried D. Use of an optical clearing agent to enhance the visibility of subsurface structures and lesions from tooth occlusal surfaces. J Biomed Opt. 2016 Aug; 21(8):081206. PMID: 27071709.
      View in: PubMed
    41. Algarni A, Kang H, Fried D, Eckert GJ, Hara AT. Enamel Thickness Determination by Optical Coherence Tomography: In vitro Validation. Caries Res. 2016; 50(4):400-6. PMID: 27454764.
      View in: PubMed
    42. Simon JC, Lucas SA, Staninec M, Tom H, Chan KH, Darling CL, Cozin MJ, Lee RC, Fried D. Near-IR transillumination and reflectance imaging at 1,300?nm and 1,500-1,700?nm for in vivo caries detection. Lasers Surg Med. 2016 11; 48(9):828-836. PMID: 27389018.
      View in: PubMed
    43. Lee RC, Darling CL, Staninec M, Ragadio A, Fried D. Activity assessment of root caries lesions with thermal and near-IR imaging methods. J Biophotonics. 2017 Mar; 10(3):433-445. PMID: 27060450.
      View in: PubMed
    44. Lee RC, Staninec M, Le O, Fried D. Infrared Methods for Assessment of the Activity of Natural Enamel Caries Lesions. IEEE J Sel Top Quantum Electron. 2016 May-Jun; 22(3). PMID: 27642246.
      View in: PubMed
    45. Chan KH, Tom H, Lee RC, Kang H, Simon JC, Staninec M, Darling CL, Pelzner RB, Fried D. Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention. Lasers Surg Med. 2016 12; 48(10):915-923. PMID: 26955902.
      View in: PubMed
    46. Yi I, Chan KH, Tsuji GH, Staninec M, Darling CL, Fried D. Selective removal of esthetic composite restorations with spectral guided laser ablation. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997742.
      View in: PubMed
    47. Simon JC, Darling CL, Fried D. A system for simultaneous near-infrared reflectance and transillumination imaging of occlusal carious lesions. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006524.
      View in: PubMed
    48. Almaz EC, Simon JC, Fried D, Darling CL. Influence of stains on lesion contrast in the pits and fissures of tooth occlusal surfaces from 800-1600-nm. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997740.
      View in: PubMed
    49. Tam W, Lee RC, Lin B, Simon JC, Fried D. Assessment of simulated lesions on primary teeth with near-infrared imaging. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997743.
      View in: PubMed
    50. Chan KH, Jew JM, Fried D. A new sealed RF-excited CO2 laser for enamel ablation operating at 9.4-µm with a pulse duration of 26-µs. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006521.
      View in: PubMed
    51. Lee RC, Darling CL, Fried D. Assessment of remineralized dentin lesions with thermal and near-infrared reflectance imaging. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006522.
      View in: PubMed
    52. Kim JW, Chan KH, Fried D. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27006523.
      View in: PubMed
    53. Kang H, Darling CL, Fried D. Enhancement of OCT images with vinyl polysiloxane (VPS). Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 27011417.
      View in: PubMed
    54. Fried WA, Chan KH, Darling CL, Fried D. Selective removal of dental composite with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9692. PMID: 26997741.
      View in: PubMed
    55. Simon JC, A Lucas S, Lee RC, Darling CL, Staninec M, Vaderhobli R, Pelzner R, Fried D. Near-infrared imaging of secondary caries lesions around composite restorations at wavelengths from 1300-1700-nm. Dent Mater. 2016 Apr; 32(4):587-95. PMID: 26876234.
      View in: PubMed
    56. Tom H, Chan KH, Darling CL, Fried D. Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces. Lasers Surg Med. 2016 Jan; 48(1):52-61. PMID: 26763111.
      View in: PubMed
    57. Lee RC, Darling CL, Fried D. Assessment of remineralization via measurement of dehydration rates with thermal and near-IR reflectance imaging. J Dent. 2015 Aug; 43(8):1032-42. PMID: 25862275.
      View in: PubMed
    58. Kang H, Darling CL, Tom H, Fried D. Enhanced detection of dentinal lesions in OCT images using the RKT transformation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914493.
      View in: PubMed
    59. Simon JC, Lucas S, Lee R, Darling CL, Staninec M, Vanderhobli R, Pelzner R, Fried D. In vitro near-infrared imaging of natural secondary caries. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914495.
      View in: PubMed
    60. Yan R, Chan KH, Tom H, Simon JC, Darling CL, Fried D. Selective removal of dental caries with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914496.
      View in: PubMed
    61. Tom H, Chan KH, Saltiel D, Fried D. Selective removal of demineralized enamel using a CO2 laser coupled with near-IR reflectance imaging. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914497.
      View in: PubMed
    62. Chung LC, Tom H, Chan KH, Simon JC, Fried D, Darling CL. Image-guided removal of occlusal caries lesions with a ?= 9.3-µm CO2 laser using near-IR transillumination. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914498.
      View in: PubMed
    63. Chan KH, Tom H, Darling CL, Fried D. Serial removal of caries lesions from tooth occlusal surfaces using near-IR image-guided IR laser ablation. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914499.
      View in: PubMed
    64. Lee RC, Darling CL, Fried D. Assessment of remineralization in simulated enamel lesions via dehydration with near-IR reflectance imaging. Proc SPIE Int Soc Opt Eng. 2015 Feb 24; 9306. PMID: 25914494.
      View in: PubMed
    65. Chan KH, Tom H, Darling CL, Fried D. A method for monitoring enamel erosion using laser irradiated surfaces and optical coherence tomography. Lasers Surg Med. 2014 Nov; 46(9):672-8. PMID: 25147133.
      View in: PubMed
    66. Lee RC, Kang H, Darling CL, Fried D. Automated assessment of the remineralization of artificial enamel lesions with polarization-sensitive optical coherence tomography. Biomed Opt Express. 2014 Sep 01; 5(9):2950-62. PMID: 25401009.
      View in: PubMed
    67. Nee A, Chan K, Kang H, Staninec M, Darling CL, Fried D. Longitudinal monitoring of demineralization peripheral to orthodontic brackets using cross polarization optical coherence tomography. J Dent. 2014 May; 42(5):547-55. PMID: 24561340.
      View in: PubMed
    68. Lamantia NR, Tom H, Chan KH, Simon JC, Darling CL, Fried D. High contrast optical imaging methods for image guided laser ablation of dental caries lesions. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929. PMID: 24791129.
      View in: PubMed
    69. Simon JC, Lucas SA, Staninec M, Tom H, Chan KH, Darling CL, Fried D. Transillumination and reflectance probes for in vivo near-IR imaging of dental caries. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290D. PMID: 24817803.
      View in: PubMed
    70. Lee RC, Darling CL, Fried D. Automated detection of remineralization in simulated enamel lesions with PS-OCT. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290E. PMID: 25075267.
      View in: PubMed
    71. Chan KH, Tom H, Fried D. Monitoring the inhibition of erosion by a CO2 laser with OCT. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290F. PMID: 24817804.
      View in: PubMed
    72. Kang H, Darling CL, Fried D. Enhancing the detection of hidden occlusal caries lesions with OCT using high index liquids. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290O. PMID: 24817805.
      View in: PubMed
    73. Fried WA, Simon JC, Lucas S, Chan KH, Darling CL, Staninec M, Fried D. Near-IR imaging of cracks in teeth. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290Q. PMID: 24817806.
      View in: PubMed
    74. Tom H, Chan KH, Darling CL, Fried D. Near-IR imaging of demineralization under sealants. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290S. PMID: 24817807.
      View in: PubMed
    75. Chan AC, Darling CL, Chan KH, Fried D. Attenuation of near-IR light through dentin at wavelengths from 1300-1650-nm. Proc SPIE Int Soc Opt Eng. 2014 Feb 18; 8929:89290M. PMID: 24839373.
      View in: PubMed
    76. Chan KH, Hirasuna K, Fried D. Analysis of enamel surface damage after selective laser ablation of composite from tooth surfaces. Photonics Lasers Med. 2014 Feb 01; 3(1):37-45. PMID: 24707453.
      View in: PubMed
    77. Tom H, Simon JC, Chan KH, Darling CL, Fried D. Near-infrared imaging of demineralization under sealants. J Biomed Opt. 2014; 19(7):77003. PMID: 25036214.
      View in: PubMed
    78. Simon JC, Chan KH, Darling CL, Fried D. Multispectral near-IR reflectance imaging of simulated early occlusal lesions: variation of lesion contrast with lesion depth and severity. Lasers Surg Med. 2014 Mar; 46(3):203-15. PMID: 24375543.
      View in: PubMed
    79. Chan KH, Chan AC, Fried WA, Simon JC, Darling CL, Fried D. Use of 2D images of depth and integrated reflectivity to represent the severity of demineralization in cross-polarization optical coherence tomography. J Biophotonics. 2015 Jan; 8(1-2):36-45. PMID: 24307350.
      View in: PubMed
    80. Fried WA, Fried D, Chan KH, Darling CL. High contrast reflectance imaging of simulated lesions on tooth occlusal surfaces at near-IR wavelengths. Lasers Surg Med. 2013 Oct; 45(8):533-41. PMID: 23857066.
      View in: PubMed
    81. Chan KH, Chan AC, Darling CL, Fried D. Methods for Monitoring Erosion Using Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566:856606. PMID: 24465117.
      View in: PubMed
    82. Fried D, Staninec M, Darling CL, Chan KH, Pelzner RB. Clinical Monitoring of Early Caries Lesions using Cross Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353384.
      View in: PubMed
    83. Fried WA, Fried D, Chan KH, Darling CL. Imaging Early Demineralization on Tooth Occlusal Surfaces with a High Definition InGaAs Camera. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24357911.
      View in: PubMed
    84. Kang H, Chan K, Darling CL, Fried D. Monitoring the Remineralization of Early Simulated Lesions using a pH Cycling Model with CP-OCT. Proc SPIE Int Soc Opt Eng. 2013 Mar 25; 8566. PMID: 24353383.
      View in: PubMed
    85. Darling CL, Staninec M, Chan KH, Kang H, Fried D. Remineralization of Root Caries Monitored Using Cross-Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8208. PMID: 24357904.
      View in: PubMed
    86. Kang H, Darling CL, Fried D. Nondestructive Monitoring of the Repair of Natural Occlusal Lesions using Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8208. PMID: 23538837.
      View in: PubMed
    87. Nahm BJ, Kang H, Chan K, Fried D. Investigation of Acid-Etched CO2 Laser Ablated Enamel Surfaces Using Polarization Sensitive Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8208. PMID: 23539418.
      View in: PubMed
    88. Fried D, Staninec M, Darling C, Kang H, Chan K. Monitoring tooth demineralization using a cross polarization optical coherence tomographic system with an integrated MEMS scanner. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8208. PMID: 24357905.
      View in: PubMed
    89. Chan KH, Fried D. Selective Removal of Demineralization Using Near Infrared Cross Polarization Reflectance and a Carbon Dioxide Laser. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8208. PMID: 24357906.
      View in: PubMed
    90. Kang H, Darling CL, Fried D. Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography. Dent Mater. 2012 May; 28(5):488-94. PMID: 22204914.
      View in: PubMed
    91. Staninec M, Douglas SM, Darling CL, Chan K, Kang H, Lee RC, Fried D. Non-destructive clinical assessment of occlusal caries lesions using near-IR imaging methods. Lasers Surg Med. 2011 Dec; 43(10):951-9. PMID: 22109697.
      View in: PubMed
    92. Chung S, Fried D, Staninec M, Darling CL. Multispectral near-IR reflectance and transillumination imaging of teeth. Biomed Opt Express. 2011 Oct 01; 2(10):2804-14. PMID: 22025986.
      View in: PubMed
    93. Chan KH, Hirasuna K, Fried D. Rapid and selective removal of composite from tooth surfaces with a 9.3 µm CO2 laser using spectral feedback. Lasers Surg Med. 2011 Sep; 43(8):824-32. PMID: 21956630.
      View in: PubMed
    94. Rechmann P, Fried D, Le CQ, Nelson G, Rapozo-Hilo M, Rechmann BM, Featherstone JD. Caries inhibition in vital teeth using 9.6-µm CO2-laser irradiation. J Biomed Opt. 2011 Jul; 16(7):071405. PMID: 21806251.
      View in: PubMed
    95. Nguyen D, Chang K, Hedayatollahnajafi S, Staninec M, Chan K, Lee R, Fried D. High-speed scanning ablation of dental hard tissues with a ? = 9.3 µm CO2 laser: adhesion, mechanical strength, heat accumulation, and peripheral thermal damage. J Biomed Opt. 2011 Jul; 16(7):071410. PMID: 21806256.
      View in: PubMed
    96. Fried D, Staninec M, Darling CL, Lee C, Kang H, Chan KH. In vivo Near-IR Imaging of Occlusal Lesions at 1310-nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840B). PMID: 21785532.
      View in: PubMed
    97. Kang H, Darling CL, Fried D. Repair of Artificial Lesions using an Acidic Remineralization Model Monitored with Cross - Polarization Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2011 Jan 23; 7884(78840Q). PMID: 21785533.
      View in: PubMed
    98. Chang KK, Staninec M, Chan KH, Fried D. Adhesion studies on dental enamel surfaces irradiated by a rapidly scanned carbon dioxide laser. Proc SPIE Int Soc Opt Eng. 2011 Jan 01; 7884. PMID: 21998494.
      View in: PubMed
    99. Chung S, Fried D, Staninec M, Darling CL. Near infrared imaging of teeth at wavelengths between 1200 and 1600 nm. Proc SPIE Int Soc Opt Eng. 2011 Jan 01; 7884. PMID: 22399836.
      View in: PubMed
    100. Darling CL, Chan KH, Fried D. Polarization Resolved Near-IR Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2011 Jan 01; 7884. PMID: 22399837.
      View in: PubMed
    101. Chan KH, Fried D. Selective Removal of Dental Composite using a Rapidly Scanned Carbon Dioxide Laser. Proc SPIE Int Soc Opt Eng. 2011; 7884:78840R1-78840R5. PMID: 21927546.
      View in: PubMed
    102. Louie T, Lee C, Hsu D, Hirasuna K, Manesh S, Staninec M, Darling CL, Fried D. Clinical assessment of early tooth demineralization using polarization sensitive optical coherence tomography. Lasers Surg Med. 2010 Dec; 42(10):738-45. PMID: 21246578.
      View in: PubMed
    103. Lee C, Lee D, Darling CL, Fried D. Nondestructive assessment of the severity of occlusal caries lesions with near-infrared imaging at 1310 nm. J Biomed Opt. 2010 Jul-Aug; 15(4):047011. PMID: 20799842.
      View in: PubMed
    104. Kang H, Jiao JJ, Lee C, Le MH, Darling CL, Fried D. Nondestructive Assessment of Early Tooth Demineralization Using Cross-Polarization Optical Coherence Tomography. IEEE J Sel Top Quantum Electron. 2010 Jul; 16(4):870-876. PMID: 21660217.
      View in: PubMed
    105. Staninec M, Lee C, Darling CL, Fried D. In vivo near-IR imaging of approximal dental decay at 1,310 nm. Lasers Surg Med. 2010 Apr; 42(4):292-8. PMID: 20432277.
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    106. Stahl J, Kang H, Fried D. Imaging Simulated Secondary Caries Lesions with Cross Polarization OCT. Proc SPIE Int Soc Opt Eng. 2010 Mar 05; 7549:754905. PMID: 21892257.
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    107. Maung LH, Lee C, Fried D. Near-IR Imaging of Thermal Changes in Enamel during Laser Ablation. Proc SPIE Int Soc Opt Eng. 2010 Mar 05; 7546(1). PMID: 21935291.
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    108. Lee C, Darling CL, Fried D. In vitro near-infrared imaging of occlusal dental caries using germanium enhanced CMOS camera. Proc SPIE Int Soc Opt Eng. 2010 Mar 01; 7549. PMID: 22162916.
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    109. Darling CL, Jiao JJ, Lee C, Kang H, Fried D. Near-IR Polarization Imaging of Sound and Carious Dental Enamel. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490L. PMID: 22228980.
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    110. Le MH, Darling CL, Fried D. Automated analysis of lesion depth and integrated reflectivity in PS-OCT scans of tooth demineralization. Lasers Surg Med. 2010 Jan; 42(1):62-8. PMID: 20077486.
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    111. Kang H, Jiao JJ, Lee C, Darling CL, Fried D. Imaging early demineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2010 Jan 01; 7549. PMID: 22399835.
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    112. Douglas SM, Fried D, Darling CL. Imaging Natural Occlusal Caries Lesions with Optical Coherence Tomography. Proc SPIE Int Soc Opt Eng. 2010; 7549:75490N. PMID: 22228981.
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    113. Tao YC, Fried D. Near-infrared image-guided laser ablation of dental decay. J Biomed Opt. 2009 Sep-Oct; 14(5):054045. PMID: 19895146.
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    114. Manesh SK, Darling CL, Fried D. Nondestructive assessment of dentin demineralization using polarization-sensitive optical coherence tomography after exposure to fluoride and laser irradiation. J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):802-12. PMID: 19283826.
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    115. Manesh SK, Darling CL, Fried D. Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin. J Biomed Opt. 2009 Jul-Aug; 14(4):044002. PMID: 19725714.
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    116. Staninec M, Darling CL, Goodis HE, Pierre D, Cox DP, Fan K, Larson M, Parisi R, Hsu D, Manesh SK, Ho C, Hosseini M, Fried D. Pulpal effects of enamel ablation with a microsecond pulsed lambda = 9.3-microm CO2 laser. Lasers Surg Med. 2009 Apr; 41(4):256-63. PMID: 19347946.
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    117. Lee C, Hsu DJ, Le MH, Darling CL, Fried D. Non-destructive measurement of demineralization & remineralization in the occlusal pits and fissures of extracted 3 molars with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Mar 06; 7162(1). PMID: 21935289.
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    118. Wu J, Fried D. High contrast near-infrared polarized reflectance images of demineralization on tooth buccal and occlusal surfaces at lambda = 1310-nm. Lasers Surg Med. 2009 Mar; 41(3):208-13. PMID: 19291753.
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    119. Hedayatollahnajafi S, Staninec M, Watanabe L, Lee C, Fried D. Dentin bond strength after ablation using a CO(2) laser operating at high pulse repetition rates. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162:71620F. PMID: 21892256.
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    120. Darling CL, Le CQ, Featherstone JD, Fried D. An Automated Digital Microradiography System for Assessing Tooth Demineralization. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935288.
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    121. Le MH, Darling CL, Fried D. Methods for calculating the severity of demineralization on tooth surfaces from PS-OCT scans. Proc SPIE Int Soc Opt Eng. 2009 Feb 18; 7162(1). PMID: 21935290.
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    122. Lee C, Darling CL, Fried D. Polarization-sensitive optical coherence tomographic imaging of artificial demineralization on exposed surfaces of tooth roots. Dent Mater. 2009 Jun; 25(6):721-8. PMID: 19167052.
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    123. Pugach MK, Strother J, Darling CL, Fried D, Gansky SA, Marshall SJ, Marshall GW. Dentin caries zones: mineral, structure, and properties. J Dent Res. 2009 Jan; 88(1):71-6. PMID: 19131321.
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    124. Manesh SK, Darling CL, Fried D. Assessment of Dentin Remineralization with PS-OCT. Proc SPIE Int Soc Opt Eng. 2009 Jan 01; 7162. PMID: 21998493.
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    125. Lee D, Fried D, Darling CL. Near-IR Multi-modal Imaging of Natural Occlusal Lesions. Proc SPIE Int Soc Opt Eng. 2009; 7162:71620X. PMID: 22228979.
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    126. Staninec M, Meshkin N, Manesh SK, Ritchie RO, Fried D. Weakening of dentin from cracks resulting from laser irradiation. Dent Mater. 2009 Apr; 25(4):520-5. PMID: 19062088.
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    127. Hsu DJ, Darling CL, Lachica MM, Fried D. Nondestructive assessment of the inhibition of enamel demineralization by CO2 laser treatment using polarization sensitive optical coherence tomography. J Biomed Opt. 2008 Sep-Oct; 13(5):054027. PMID: 19021407.
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    128. Can AM, Darling CL, Ho C, Fried D. Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a lambda=9.3-microm CO2 laser at ablative irradiation intensities with PS-OCT. Lasers Surg Med. 2008 Jul; 40(5):342-9. PMID: 18563781.
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    129. Hirasuna K, Fried D, Darling CL. Near-infrared imaging of developmental defects in dental enamel. J Biomed Opt. 2008 Jul-Aug; 13(4):044011. PMID: 19021339.
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    130. Hsu DJ, Darling CL, Fried D. Imaging laser irradiated enamel surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:8430N-N8430. PMID: 21909224.
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    131. Tao YC, Fried D. Selective Removal of Natural Occlusal Caries by Coupling Near-infrared Imaging with a CO(2) Laser. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430I-68430I8. PMID: 21909225.
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    132. Can AM, Darling CL, Fried D. High-resolution PS-OCT of Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430T1-68430T7. PMID: 21909226.
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    133. Darling CL, Fried D. Real-time near IR (1310 nm) imaging of CO2 laser ablation of enamel. Opt Express. 2008 Feb 18; 16(4):2685-93. PMID: 18542353.
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    134. Darling CL, Maffei ME, Fried WA, Fried D. Near-IR imaging of Erbium Laser Ablation with a Water Spray. Proc SPIE Int Soc Opt Eng. 2008 Jan 20; 6843(684303). PMID: 21892255.
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    135. Manesh SK, Darling CL, Fried D. Imaging natural and artificial demineralization on dentin surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Jan 01; 6843. PMID: 21998492.
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    136. Assa S, Meyer S, Fried D. Ablation of Dental Hard Tissues with a Microsecond Pulsed Carbon Dioxide Laser Operating at 9.3-µm with an Integrated Scanner. Proc SPIE Int Soc Opt Eng. 2008; 6843:684308. PMID: 22228978.
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    137. Chong SL, Darling CL, Fried D. Nondestructive measurement of the inhibition of demineralization on smooth surfaces using polarization-sensitive optical coherence tomography. Lasers Surg Med. 2007 Jun; 39(5):422-7. PMID: 17565731.
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    138. Tao YC, Fan K, Fried D. Near-infrared image-guided laser ablation of artificial caries lesions. Proc SPIE Int Soc Opt Eng. 2007; 6425:64250T. PMID: 22866210.
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    139. Fan K, Bell P, Fried D. Rapid and conservative ablation and modification of enamel, dentin, and alveolar bone using a high repetition rate transverse excited atmospheric pressure CO2 laser operating at lambda=9.3 micro. J Biomed Opt. 2006 Nov-Dec; 11(6):064008. PMID: 17212531.
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    140. Staninec M, Gardner AK, Le CQ, Sarma AV, Fried D. Adhesion of composite to enamel and dentin surfaces irradiated by IR laser pulses of 0.5-35 micros duration. J Biomed Mater Res B Appl Biomater. 2006 Oct; 79(1):193-201. PMID: 16637032.
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    141. Fried D, Featherstone JD, Le CQ, Fan K. Dissolution studies of bovine dental enamel surfaces modified by high-speed scanning ablation with a lambda = 9.3-microm TEA CO(2) laser. Lasers Surg Med. 2006 Oct; 38(9):837-45. PMID: 17044095.
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    142. Jones RS, Fried D. Remineralization of enamel caries can decrease optical reflectivity. J Dent Res. 2006 Sep; 85(9):804-8. PMID: 16931861.
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    143. Darling CL, Huynh GD, Fried D. Light scattering properties of natural and artificially demineralized dental enamel at 1310 nm. J Biomed Opt. 2006 May-Jun; 11(3):34023. PMID: 16822072.
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    144. Jones RS, Darling CL, Featherstone JD, Fried D. Imaging artificial caries on the occlusal surfaces with polarization-sensitive optical coherence tomography. Caries Res. 2006; 40(2):81-9. PMID: 16508263.
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    145. Jones RS, Darling CL, Featherstone JD, Fried D. Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography. J Biomed Opt. 2006 Jan-Feb; 11(1):014016. PMID: 16526893.
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    146. Fried D, Featherstone JD, Darling CL, Jones RS, Ngaotheppitak P, Bühler CM. Early caries imaging and monitoring with near-infrared light. Dent Clin North Am. 2005 Oct; 49(4):771-93, vi. PMID: 16150316.
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    147. Ngaotheppitak P, Darling CL, Fried D. Measurement of the severity of natural smooth surface (interproximal) caries lesions with polarization sensitive optical coherence tomography. Lasers Surg Med. 2005 Jul; 37(1):78-88. PMID: 15889402.
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    148. Bühler C, Ngaotheppitak P, Fried D. Imaging of occlusal dental caries (decay) with near-IR light at 1310-nm. Opt Express. 2005 Jan 24; 13(2):573-82. PMID: 19488387.
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    149. Louie TM, Jones RS, Sarma AV, Fried D. Selective removal of composite sealants with near-ultraviolet laser pulses of nanosecond duration. J Biomed Opt. 2005 Jan-Feb; 10(1):14001. PMID: 15847582.
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    150. Fried NM, Yang Y, Chaney CA, Fried D. Transmission of Q-switched erbium:YSGG (lambda=2.79 microm) and erbium:YAG (lambda=2.94 microm) laser radiation through germanium oxide and sapphire optical fibres at high pulse energies. Lasers Med Sci. 2004; 19(3):155-60. PMID: 15645320.
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    151. Jones RS, Staninec M, Fried D. Imaging artificial caries under composite sealants and restorations. J Biomed Opt. 2004 Nov-Dec; 9(6):1297-304. PMID: 15568951.
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    152. Goodis HE, Fried D, Gansky S, Rechmann P, Featherstone JD. Pulpal safety of 9.6 microm TEA CO2 laser used for caries prevention. Lasers Surg Med. 2004; 35(2):104-10. PMID: 15334612.
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    153. Dela Rosa A, Sarma AV, Le CQ, Jones RS, Fried D. Peripheral thermal and mechanical damage to dentin with microsecond and sub-microsecond 9.6 microm, 2.79 microm, and 0.355 microm laser pulses. Lasers Surg Med. 2004; 35(3):214-28. PMID: 15389737.
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    154. Sheth KK, Staninec M, Sarma AV, Fried D. Selective targeting of protein, water, and mineral in dentin using UV and IR pulse lasers: the effect on the bond strength to composite restorative materials. Lasers Surg Med. 2004; 35(4):245-53. PMID: 15493023.
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    155. Jones R, Huynh G, Jones G, Fried D. Near-infrared transillumination at 1310-nm for the imaging of early dental decay. Opt Express. 2003 Sep 08; 11(18):2259-65. PMID: 19466117.
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    156. Wheeler CR, Fried D, Featherstone JD, Watanabe LG, Le CQ. Irradiation of dental enamel with Q-switched lambda = 355-nm laser pulses: surface morphology, fluoride adsorption, and adhesion to composite resin. Lasers Surg Med. 2003; 32(4):310-7. PMID: 12696100.
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    157. Staninec M, Xie J, Le CQ, Fried D. Influence of an optically thick water layer on the bond-strength of composite resin to dental enamel after IR laser ablation. Lasers Surg Med. 2003; 33(4):264-9. PMID: 14571452.
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    158. Fried D, Xie J, Shafi S, Featherstone JD, Breunig TM, Le C. Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography. J Biomed Opt. 2002 Oct; 7(4):618-27. PMID: 12421130.
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    159. Fried D, Zuerlein MJ, Le CQ, Featherstone JD. Thermal and chemical modification of dentin by 9-11-microm CO2 laser pulses of 5-100-micros duration. Lasers Surg Med. 2002; 31(4):275-82. PMID: 12355574.
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    160. Harris DM, White JM, Goodis H, Arcoria CJ, Simon J, Carpenter WM, Fried D, Burkart J, Yessik M, Myers T. Selective ablation of surface enamel caries with a pulsed Nd:YAG dental laser. Lasers Surg Med. 2002; 30(5):342-50. PMID: 12116326.
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    161. Alexander R, Xie J, Fried D. Selective removal of residual composite from dental enamel surfaces using the third harmonic of a Q-switched Nd:YAG laser. Lasers Surg Med. 2002; 30(3):240-5. PMID: 11891745.
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    162. Fried D, Ashouri N, Breunig T, Shori R. Mechanism of water augmentation during IR laser ablation of dental enamel. Lasers Surg Med. 2002; 31(3):186-93. PMID: 12224092.
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    163. Fried D, Ragadio J, Akrivou M, Featherstone JD, Murray MW, Dickenson KM. Dental hard tissue modification and removal using sealed transverse excited atmospheric-pressure lasers operating at lambda=9.6 and 10.6 microm. J Biomed Opt. 2001 Apr; 6(2):231-8. PMID: 11375734.
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    164. Fried D, Ragadio J, Champion A. Residual heat deposition in dental enamel during IR laser ablation at 2.79, 2.94, 9.6, and 10.6 microm. Lasers Surg Med. 2001; 29(3):221-9. PMID: 11573223.
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    165. Dumore T, Fried D. Selective ablation of orthodontic composite by using sub-microsecond IR laser pulses with optical feedback. Lasers Surg Med. 2000; 27(2):103-10. PMID: 10960816.
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    166. Zuerlein MJ, Fried D, Featherstone JD. Modeling the modification depth of carbon dioxide laser-treated dental enamel. Lasers Surg Med. 1999; 25(4):335-47. PMID: 10534750.
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    167. Featherstone JD, Barrett-Vespone NA, Fried D, Kantorowitz Z, Seka W. CO2 laser inhibitor of artificial caries-like lesion progression in dental enamel. J Dent Res. 1998 Jun; 77(6):1397-403. PMID: 9649168.
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    168. Fried D, Glena RE, Featherstone JD, Seka W. Permanent and transient changes in the reflectance of CO2 laser-irradiated dental hard tissues at lambda = 9.3, 9.6, 10.3, and 10.6 microns and at fluences of 1-20 J/cm2. Lasers Surg Med. 1997; 20(1):22-31. PMID: 9041504.
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