Daniel Fried, PhD

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
Address707 Parnassus Avenue, #2234
San Francisco CA 94143
Phone415-502-6641
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    Collapse Biography 
    Collapse education and training
    University of Toledo, Toledo, OHB.S.1984Chemistry
    University of Toledo, Toledo, OHM.Sc.1986Physical chemistry
    Wayne State University, Detroit, MIPh.D.1992Physical chemistry
    University of Rochester, Rochester, NYPostdoc. Fellow1994Biomedical optics
    Eastman Dental Center, Rochester, NYPostdoc. Fellow1994Mineralized tissue
    Collapse awards and honors
    Student Competition for Advancing Dental Research and its Application2018  - 2018Burton C. Borgelt / SCADA Faculty Advisor Award
    American Institute for Medical and Biological Engineering2018  - 2018Fellow, AIMBE
    International Association of Dental Research 2017  - 2017IADR Distinguished Scientist Award for Research in Dental Caries
    Pierre Fauchard Academy2011  - 2011Excellence in Dental education
    UCSF - School of Dentistry 2010  - 2010Faculty Research Award Lecturer
    Academy of Laser Dentistry2009  - 2009T.H. Maiman Award
    2006  - 2006Omicron Kappa Upsilon
    Michigan Polymer Consortium1991  - 1991Polymer Fellowship
    1991  - 1991Sigma Xi
    1987  - 1987Jasper Graduate Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Imaging Dental Caries with SWIR Light
    NIH R01DE028295Aug 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Optical Methods for Lesion Activity Assessment
    NIH R01DE027335Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Selective Ablation of Dental Caries and Composites
    NIH R01DE019631Sep 1, 2009 - Mar 31, 2019
    Role: Principal Investigator
    Clinical Assessment of Tooth Demineralization & Remineralization with PS-OCT
    NIH R01DE017869Aug 15, 2006 - Jul 31, 2016
    Role: Principal Investigator
    Early Caries Detection with Near-IR Light
    NIH R01DE014698Aug 1, 2002 - Apr 30, 2018
    Role: Principal Investigator
    Laser Ablation of Dental Hard Tissues
    NIH R01DE014554Jun 1, 2002 - May 31, 2008
    Role: Principal Investigator
    MULTIPURPOSE CO2 TEA LASER FOR DENTAL APPLICATIONS
    NIH R41DE012971Aug 1, 2000 - Jul 31, 2001
    Role: Principal Investigator
    IR LASER ABLATION OF DENTAL HARD TISSUE
    NIH R29DE012091Aug 1, 1997 - May 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Optimal Wavelengths for Multispectral Short Wavelength Infrared Transillumination and Reflectance Imaging for Caries Detection. Diagnostics (Basel). 2025 Apr 18; 15(8). Fried D, Zhu Y. PMID: 40310441; PMCID: PMC12026095.
      View in: PubMed   Mentions:
    2. Assessment of the activity of root caries lesions using short wavelength infrared imaging - an in vitro pilot study. J Dent. 2025 Jun; 157:105769. Wycoff S, Fried D. PMID: 40252948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. In vitro Assessment of lesion activity using simultaneous time-resolved reflectance imaging at 1300 and 1950 nm. Lasers Med Sci. 2024 Aug 27; 39(1):223. Wycoff S, Zhu Y, Fried D. PMID: 39191998.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Clinical SWIR and CP-OCT imaging of interproximal lesions. BMC Oral Health. 2024 Aug 17; 24(1):959. Zhu Y, Le O, Xue J, Wycoff S, Fried D. PMID: 39153971; PMCID: PMC11330057.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Short-Wavelength Infrared Imaging of Infected and Affected Dentin. Diagnostics (Basel). 2024 Mar 30; 14(7). Ng M, Ho YC, Wycoff S, Zhu Y, Fried D. PMID: 38611657; PMCID: PMC11012186.
      View in: PubMed   Mentions: 1  
    6. Special Section Guest Editorial: Short Wave Infrared Techniques and Applications in Biomedical Optics. J Biomed Opt. 2023 09; 28(9):094800. Fried D, Pierce M, Roblyer D. PMID: 37692561; PMCID: PMC10492591.
      View in: PubMed   Mentions:    Fields:    
    7. Longitudinal assessment of dental erosion-abrasion by cross-polarization optical coherence tomography in vitro. Braz Oral Res. 2023; 37:e081. Romero MJR, Bezerra SJC, Fried D, Lippert F, Eckert GJ, Hara AT. PMID: 37672415.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Diagnostic Performance of Multispectral SWIR Transillumination and Reflectance Imaging for Caries Detection. Diagnostics (Basel). 2023 Aug 31; 13(17). Zhu Y, Ng C, Le O, Ho YC, Fried D. PMID: 37685362; PMCID: PMC10487234.
      View in: PubMed   Mentions: 3  
    9. Exploratory Analysis of Objective Outcome Measures for the Clinical Assessment of Erosive Tooth Wear. Diagnostics (Basel). 2023 Aug 02; 13(15). Romero MJRH, Ungar PS, Fried D, Lippert F, Zero DT, Zunt S, Eckert GJ, Gossweiler AG, Elkington-Stauss DJ, Tamayo-Cabeza G, Kelly AB, Bartels T, Kita C, Wewers E, Hara AT. PMID: 37568931; PMCID: PMC10417370.
      View in: PubMed   Mentions: 1  
    10. Time-resolved SWIR imaging for the assessment of the activity of occlusal caries lesions. J Biophotonics. 2023 10; 16(10):e202300165. Ng M, Wycoff S, Zhu Y, Ho YC, Takasuka H, Fried D. PMID: 37316468; PMCID: PMC10846334.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Monitoring lesion activity on primary teeth with CP-OCT and SWIR reflectance imaging. Lasers Surg Med. 2023 08; 55(6):601-609. Zhu Y, Kim J, Lin B, Fried D. PMID: 37172310.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Active Surveillance of Root Caries in Vivo with CP-OCT. Diagnostics (Basel). 2023 Jan 27; 13(3). Zhu Y, Kim M, Curtis D, Wang J, Le O, Fried D. PMID: 36766570; PMCID: PMC9914565.
      View in: PubMed   Mentions: 1  
    13. Assessment of the activity of secondary caries lesions with short-wavelength infrared, thermal, and optical coherence tomographic imaging. J Biomed Opt. 2023 09; 28(9):094801. Chang NN, Dillas T, Zhu Y, Fried D. PMID: 36761935; PMCID: PMC9830003.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Evaluating interproximal and occlusal lesion severity with a dual SWIR transillumination/reflectance probe. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11942. Zhu Y, Fried D. PMID: 35444360; PMCID: PMC9017391.
      View in: PubMed   Mentions: 1  
    15. Use of SWIR dehydration and OCT to assess the complete arrest of simulated incipient caries lesions. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11942. Chang NY, Tressel J, Kashirtsev F, Fried D. PMID: 35444361; PMCID: PMC9017390.
      View in: PubMed   Mentions:
    16. Caries inhibition of simulated active caries lesions with CO2 laser irradiation and fluoride. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11942. Tressel J, Kashirtsev F, Cheung K, Simon J, Fried D. PMID: 35450400; PMCID: PMC9020385.
      View in: PubMed   Mentions:
    17. Assessing lesion activity of secondary lesions on extracted teeth by thermal dehydration measurement and optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11942. Chang NN, Dillas T, Fried D. PMID: 35450401; PMCID: PMC9020384.
      View in: PubMed   Mentions: 1  
    18. Dehydration imaging of dental fluorosis at 1950 nm. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11942. Kashirtsev F, Tressel J, Fried D. PMID: 35440838; PMCID: PMC9014758.
      View in: PubMed   Mentions: 1  
    19. Measurement of the Depth of Lesions on Proximal Surfaces with SWIR Multispectral Transillumination and Reflectance Imaging. Diagnostics (Basel). 2022 Feb 26; 12(3). Zhu Y, Fried D. PMID: 35328150; PMCID: PMC8947190.
      View in: PubMed   Mentions: 4  
    20. Monitoring silver diamine fluoride application with optical coherence tomography and thermal imaging: An in vitro proof of concept study. Lasers Surg Med. 2022 07; 54(5):790-803. Abdelaziz M, Yang V, Chang NN, Darling C, Fried W, Seto J, Fried D. PMID: 35212407; PMCID: PMC9189075.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. High contrast imaging of dental fluorosis in the short wavelength infrared. J Biophotonics. 2021 10; 14(10):e202100145. Kashirtsev F, Tressel J, Simon JC, Fried D. PMID: 34302430; PMCID: PMC9380435.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Cross-polarization optical coherence tomographic assessment of in situ simulated erosive tooth wear. J Biophotonics. 2021 09; 14(9):e202100090. Romero MJRH, Bezerra SJC, Fried D, Yang V, Lippert F, Eckert GJ, Zero DT, Hara AT. PMID: 34105881; PMCID: PMC8448929.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Computer-Controlled CO2 Laser Ablation System for Cone-beam Computed Tomography and Digital Image Guided Endodontic Access: A Pilot Study. J Endod. 2021 Sep; 47(9):1445-1452. Simon JC, Kwok JW, Vinculado F, Fried D. PMID: 34119563; PMCID: PMC8867881.
      View in: PubMed   Mentions: 4     Fields:    
    24. Dynamic SWIR imaging near the 1950-nm water absorption band for caries lesion diagnosis. J Biomed Opt. 2021 05; 26(5). Tressel JT, Abdelaziz M, Fried D. PMID: 34032036; PMCID: PMC8144227.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. High contrast reflectance imaging at 1950 nm for the assessment of lesion activity on extracted teeth. Proc SPIE Int Soc Opt Eng. 2021 Mar; 11627. Tressel J, Abdelaziz M, Fried D. PMID: 33762796; PMCID: PMC7986894.
      View in: PubMed   Mentions: 3  
    26. Infrared imaging confirms the role of the transparent surface zone in arresting dental caries. Proc SPIE Int Soc Opt Eng. 2021 Mar; 11627. Liu H, Chang NY, Gao W, Fried D. PMID: 33767521; PMCID: PMC7989780.
      View in: PubMed   Mentions: 3  
    27. Imaging dental fluorosis at SWIR wavelengths from 1300 to 2000-nm. Proc SPIE Int Soc Opt Eng. 2021 Mar; 11627. Kashirtsev F, Simon JC, Fried D. PMID: 33767522; PMCID: PMC7989784.
      View in: PubMed   Mentions: 2  
    28. Multispectral SWIR images of the pulp-chamber of posterior teeth in vitro. Proc SPIE Int Soc Opt Eng. 2021 Mar; 11627. Simon JC, Mogire EO, Yun SY, Fried D. PMID: 33776188; PMCID: PMC7993031.
      View in: PubMed   Mentions: 1  
    29. Compact in vivo handheld dual SWIR transillumination/reflectance imaging system for the detection of proximal and occlusal lesions. Proc SPIE Int Soc Opt Eng. 2021 Mar; 11627. Zhu Y, Simon J, Ng C, Fried D. PMID: 33790493; PMCID: PMC8008980.
      View in: PubMed   Mentions: 1  
    30. High Contrast Reflectance Imaging of Enamel Demineralization and Remineralization at 1950-nm for the Assessment of Lesion Activity. Lasers Surg Med. 2021 09; 53(7):968-977. Fried WA, Abdelaziz M, Darling CL, Fried D. PMID: 33442896; PMCID: PMC8275669.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    31. Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection. J Biomed Opt. 2021 01; 26(4). Zhu Y, Abdelaziz M, Simon J, Le O, Fried D. PMID: 33515220; PMCID: PMC7844424.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Thermal Imaging of Root Caries In Vivo. J Dent Res. 2020 12; 99(13):1502-1508. Yang V, Zhu Y, Curtis D, Le O, Chang NYN, Fried WA, Simon JC, Banan P, Darling CL, Fried D. PMID: 32866422; PMCID: PMC7684841.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    33. SWIR, Thermal and CP-OCT imaging probes for the in vivo assessment of the activity of root caries lesions. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Chang NY, Zhu Y, Curtis D, Le O, Yang V, Fried WA, Simon JC, Banan P, Darling CL, Fried D. PMID: 33612912; PMCID: PMC7894617.
      View in: PubMed   Mentions: 2  
    34. A dual handheld SWIR transillumination/reflectance probe for imaging lesions on tooth occlusal and proximal surfaces. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Zhu Y, Chang NY, Fried WA, Yang V, Fried D. PMID: 33603261; PMCID: PMC7888982.
      View in: PubMed   Mentions: 4  
    35. Optical Coherence Tomography (OCT) for the evaluation of internal adaptation of class V resin restorations on Dentin. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Abdelaziz M, Zuluaga AF, Betancourt F, Fried D, Krejci I, Bortolotto T. PMID: 33603262; PMCID: PMC7888983.
      View in: PubMed   Mentions: 2  
    36. A SWIR imaging handpiece for the clinical assessment of lesion activity via dehydration. Preclinical Assessment. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Fried WA, Zhu Y, Yang V, Chang NY, Fried D. PMID: 32194294; PMCID: PMC7081727.
      View in: PubMed   Mentions: 1  
    37. In vivo spectral guided removal of composite from tooth surfaces with a CO2 laser. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Simon JC, Choi JH, Jang A, Fried D. PMID: 32161428; PMCID: PMC7065526.
      View in: PubMed   Mentions: 1  
    38. A thermal imaging handpiece for the clinical assessment of lesion activity on root surfaces via dehydration. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11217. Yang VB, Chang NY, Fried D. PMID: 32231402; PMCID: PMC7105143.
      View in: PubMed   Mentions: 2  
    39. Enhancing the detection of proximal cavities on near infrared transillumination images with Indocyanine Green (ICG) as a contrast medium: In vitro proof of concept studies. J Dent. 2019 12; 91:103222. Abdelaziz M, Krejci I, Fried D. PMID: 31682898; PMCID: PMC6885130.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Measurement of the shrinkage of natural and simulated lesions on root surfaces using CP-OCT. J Dent. 2019 11; 90:103213. Yang V, Fried D. PMID: 31622647; PMCID: PMC6905190.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. In vitro longitudinal evaluation of enamel wear by cross-polarization optical coherence tomography. Dent Mater. 2019 10; 35(10):1464-1470. Alghilan MA, Lippert F, Platt JA, Eckert GJ, González-Cabezas C, Fried D, Hara AT. PMID: 31395451.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. Image-Guided Ablation of Dental Calculus From Root Surfaces Using a DPSS Er:YAG Laser. Lasers Surg Med. 2020 03; 52(3):247-258. Fried WA, Chan KH, Darling CL, Curtis DA, Fried D. PMID: 31236996; PMCID: PMC8880256.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Near-infrared imaging of demineralization on the occlusal surfaces of teeth without the interference of stains. J Biomed Opt. 2019 03; 24(3):1-8. Ng C, Almaz E, Simon J, Fried D, Darling C. PMID: 30834721; PMCID: PMC6975183.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    44. The Relationship of Dehydration Rate and Transparent Surface Layer Thickness for Coronal Lesions on Extracted Teeth. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. Chang NN, Abdelaziz M, Fried D. PMID: 30918416; PMCID: PMC6433154.
      View in: PubMed   Mentions: 1  
    45. An appliance for monitoring the shrinkage of root caries with OCT. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. Yang VB, Fried D. PMID: 30918417; PMCID: PMC6433155.
      View in: PubMed   Mentions: 1  
    46. Selective removal of dental calculus with a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. Fried WA, Chan KH, Darling CL, Fried D. PMID: 31000908; PMCID: PMC6467515.
      View in: PubMed   Mentions: 1  
    47. The contrast of demineralization on tooth occlusal surfaces from 405 to 1950-nm with varying depth. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. Mohajerani N, Chan KH, Yang VB, Fried D, Darling CL. PMID: 30923417; PMCID: PMC6434518.
      View in: PubMed   Mentions:
    48. Image guided laser ablation of demineralization from root surfaces. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10857. Dhillon N, Chan KH, Yang VB, Fried D. PMID: 31007338; PMCID: PMC6469870.
      View in: PubMed   Mentions:
    49. Impact of surface micromorphology and demineralization severity on enamel loss measurements by cross-polarization optical coherence tomography. J Dent. 2019 02; 81:52-58. Alghilan MA, Lippert F, Platt JA, Eckert GJ, González-Cabezas C, Fried D, Hara AT. PMID: 30582963.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    50. Use of a DPSS Er:YAG laser for the selective removal of composite from tooth surfaces. Biomed Opt Express. 2018 Oct 01; 9(10):5026-5036. Fried WA, Chan KH, Darling CL, Fried D. PMID: 30319919; PMCID: PMC6179409.
      View in: PubMed   Mentions: 7  
    51. Selective ablation of dental caries using coaxial Co2 (9.3-μm) and near-IR (1880-nm) lasers. Lasers Surg Med. 2019 02; 51(2):176-184. Chan KH, Fried D. PMID: 30024032; PMCID: PMC8867882.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    52. Cross-polarization reflectance imaging of root caries and dental calculus on extracted teeth at wavelengths from 400 to 2350 nm. J Biophotonics. 2018 11; 11(11):e201800113. Yang VB, Curtis DA, Fried D. PMID: 29952066.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    53. Optical Coherence Tomography. Dent Clin North Am. 2018 Jul; 62(3):421-434. Katkar RA, Tadinada SA, Amaechi BT, Fried D. PMID: 29903559.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    54. Fluorescence and Near-Infrared Light Transillumination. Dent Clin North Am. 2018 Jul; 62(3):435-452. Amaechi BT, Owosho AA, Fried D. PMID: 29903560.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. Multispectral cross-polarization reflectance measurements suggest high contrast of demineralization on tooth surfaces at wavelengths beyond 1300 nm due to reduced light scattering in sound enamel. J Biomed Opt. 2018 06; 23(6):1-4. Chan KH, Fried D. PMID: 29877068; PMCID: PMC5989821.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    56. Multispectral near-infrared reflectance and transillumination imaging of occlusal carious lesions: Variation in lesion contrast with lesion depth. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. Simon JC, Curtis DA, Darling CL, Fried D. PMID: 29497229; PMCID: PMC5827960.
      View in: PubMed   Mentions: 6  
    57. Image-guided Removal of Interproximal Lesions with a CO2 Laser. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. Ngo A, Chan KH, Le O, Simon JC, Fried D. PMID: 29497230; PMCID: PMC5827963.
      View in: PubMed   Mentions: 2  
    58. SWIR reflectance imaging of demineralization on the occlusal surfaces of teeth beyond 1700 nm. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb; 10473. Ng C, Simon JC, Fried D, Darling CL. PMID: 30686852; PMCID: PMC6345412.
      View in: PubMed   Mentions: 2  
    59. Lesion Dehydration Rate Changes with the Surface Layer Thickness during Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2018 Feb; 10473. Chang NN, Jew JM, Fried D. PMID: 30034077; PMCID: PMC6053078.
      View in: PubMed   Mentions: 8  
    60. Selective Ablation of Carious Lesions using an Integrated Near-IR Imaging System and a Novel 9.3-µm CO2 Laser. Proc SPIE Int Soc Opt Eng. 2018 Feb; 10473. Chan KH, Fried NM, Fried D. PMID: 30034078; PMCID: PMC6054456.
      View in: PubMed   Mentions: 5  
    61. Influence of multi-wavelength laser irradiation of enamel and dentin surfaces at 0.355, 2.94, and 9.4 μm on surface morphology, permeability, and acid resistance. Lasers Surg Med. 2017 12; 49(10):913-927. Chang NN, Jew JM, Simon JC, Chen KH, Lee RC, Fried WA, Cho J, Darling CL, Fried D. PMID: 28699676; PMCID: PMC5734993.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    62. Automated ablation of dental composite using an IR pulsed laser coupled to a plume emission spectral feedback system. Lasers Surg Med. 2017 09; 49(7):658-665. Jang AT, Chan KH, Fried D. PMID: 28467687; PMCID: PMC5568963.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    63. Near-IR and CP-OCT imaging of suspected occlusal caries lesions. Lasers Surg Med. 2017 03; 49(3):215-224. Simon JC, Kang H, Staninec M, Jang AT, Chan KH, Darling CL, Lee RC, Fried D. PMID: 28339115; PMCID: PMC5367963.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    64. Influence of a pulsed CO2 laser operating at 9.4  μm on the surface morphology, reflectivity, and acid resistance of dental enamel below the threshold for melting. J Biomed Opt. 2017 02 01; 22(2):28001. Kim JW, Lee R, Chan KH, Jew JM, Fried D. PMID: 28145558; PMCID: PMC5286555.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    65. Optical changes of dentin in the near-IR as a function of mineral content. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Berg RA, Simon JC, Fried D, Darling CL. PMID: 28450756; PMCID: PMC5404412.
      View in: PubMed   Mentions: 1  
    66. Automated ablation of dental composite using an IR pulsed laser coupled to a plume emission spectral feedback system. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Jang AT, Chan KH, Fried D. PMID: 28479654; PMCID: PMC5416812.
      View in: PubMed   Mentions:
    67. High-Contrast Reflectance Imaging of Composite Restorations Color-Matched to Tooth Structure at 1000-2300-nm. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Fried WA, Simon JC, Darling CL, Le O, Fried D. PMID: 28626287; PMCID: PMC5473514.
      View in: PubMed   Mentions: 1  
    68. Influence of Multi-Wavelength Laser Irradiation of Enamel and Dentin Surfaces on Surface Morphology and Permeability. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Chang NN, Jew J, Simon JC, Chan KH, Lee RC, Fried WA, Cho J, Darling CL, Fried D. PMID: 28680191; PMCID: PMC5495473.
      View in: PubMed   Mentions: 2  
    69. Assessment of cavitation in artificial approximal dental lesions with near-IR imaging. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Simon JC, Darling CL, Fried D. PMID: 28626283; PMCID: PMC5473505.
      View in: PubMed   Mentions: 7  
    70. Near-infrared imaging of enamel hypomineralization due to developmental defects. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Lee RC, Jang A, Fried D. PMID: 28626284; PMCID: PMC5473506.
      View in: PubMed   Mentions: 4  
    71. Selective Laser Ablation of Carious Lesions using Simultaneous Scanned Near-IR Diode and CO2 Lasers. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Chan KH, Fried D. PMID: 28626285; PMCID: PMC5473510.
      View in: PubMed   Mentions: 1  
    72. Synergistic effect of fluoride and laser irradiation for the inhibition of the demineralization of dental enamel. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Lee R, Chan KH, Jew J, Simon JC, Fried D. PMID: 28626286; PMCID: PMC5473511.
      View in: PubMed   Mentions: 6  
    73. Assessment of radicular dentin permeability after irradiation with CO2 laser and endodontic irrigation treatments with thermal imaging. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Cho H, Lee RC, Chan KH, Fried D. PMID: 28626288; PMCID: PMC5473517.
      View in: PubMed   Mentions:
    74. Selective removal of natural caries lesions from dentin and tooth occlusal surfaces using a diode-pumped Er:YAG laser. Proc SPIE Int Soc Opt Eng. 2017 Jan 28; 10044. Jew J, Chan KH, Darling CL, Fried D. PMID: 28450757; PMCID: PMC5404413.
      View in: PubMed   Mentions: 3  
    75. Use of an optical clearing agent to enhance the visibility of subsurface structures and lesions from tooth occlusal surfaces. J Biomed Opt. 2016 Aug; 21(8):081206. Kang H, Darling CL, Fried D. PMID: 27071709; PMCID: PMC4828753.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    76. Enamel Thickness Determination by Optical Coherence Tomography: In vitro Validation. Caries Res. 2016; 50(4):400-6. Algarni A, Kang H, Fried D, Eckert GJ, Hara AT. PMID: 27454764.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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    163. Non-destructive assessment of inhibition of demineralization in dental enamel irradiated by a lambda=9.3-microm CO2 laser at ablative irradiation intensities with PS-OCT. Lasers Surg Med. 2008 Jul; 40(5):342-9. Can AM, Darling CL, Ho C, Fried D. PMID: 18563781.
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    164. Near-infrared imaging of developmental defects in dental enamel. J Biomed Opt. 2008 Jul-Aug; 13(4):044011. Hirasuna K, Fried D, Darling CL. PMID: 19021339.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    165. Imaging laser irradiated enamel surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:8430N-N8430. Hsu DJ, Darling CL, Fried D. PMID: 21909224; PMCID: PMC3168543.
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    166. Selective Removal of Natural Occlusal Caries by Coupling Near-infrared Imaging with a CO(2) Laser. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430I-68430I8. Tao YC, Fried D. PMID: 21909225; PMCID: PMC3168534.
      View in: PubMed   Mentions: 3  
    167. High-resolution PS-OCT of Enamel Remineralization. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6843:68430T1-68430T7. Can AM, Darling CL, Fried D. PMID: 21909226; PMCID: PMC3168538.
      View in: PubMed   Mentions: 8  
    168. Real-time near IR (1310 nm) imaging of CO2 laser ablation of enamel. Opt Express. 2008 Feb 18; 16(4):2685-93. Darling CL, Fried D. PMID: 18542353.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    169. Near-IR imaging of Erbium Laser Ablation with a Water Spray. Proc SPIE Int Soc Opt Eng. 2008 Jan 20; 6843(684303). Darling CL, Maffei ME, Fried WA, Fried D. PMID: 21892255; PMCID: PMC3165031.
      View in: PubMed   Mentions:
    170. Imaging natural and artificial demineralization on dentin surfaces with polarization sensitive optical coherence tomography. Proc SPIE Int Soc Opt Eng. 2008 Jan 01; 6843. Manesh SK, Darling CL, Fried D. PMID: 21998492; PMCID: PMC3190237.
      View in: PubMed   Mentions:
    171. Ablation of Dental Hard Tissues with a Microsecond Pulsed Carbon Dioxide Laser Operating at 9.3-μm with an Integrated Scanner. Proc SPIE Int Soc Opt Eng. 2008; 6843:684308. Assa S, Meyer S, Fried D. PMID: 22228978; PMCID: PMC3251255.
      View in: PubMed   Mentions: 5  
    172. Nondestructive measurement of the inhibition of demineralization on smooth surfaces using polarization-sensitive optical coherence tomography. Lasers Surg Med. 2007 Jun; 39(5):422-7. Chong SL, Darling CL, Fried D. PMID: 17565731.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    173. Near-infrared image-guided laser ablation of artificial caries lesions. Proc SPIE Int Soc Opt Eng. 2007; 6425:64250T. Tao YC, Fan K, Fried D. PMID: 22866210; PMCID: PMC3409571.
      View in: PubMed   Mentions: 1  
    174. Rapid and conservative ablation and modification of enamel, dentin, and alveolar bone using a high repetition rate transverse excited atmospheric pressure CO2 laser operating at lambda=9.3 micro. J Biomed Opt. 2006 Nov-Dec; 11(6):064008. Fan K, Bell P, Fried D. PMID: 17212531.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    175. Adhesion of composite to enamel and dentin surfaces irradiated by IR laser pulses of 0.5-35 micros duration. J Biomed Mater Res B Appl Biomater. 2006 Oct; 79(1):193-201. Staninec M, Gardner AK, Le CQ, Sarma AV, Fried D. PMID: 16637032.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    176. Dissolution studies of bovine dental enamel surfaces modified by high-speed scanning ablation with a lambda = 9.3-microm TEA CO(2) laser. Lasers Surg Med. 2006 Oct; 38(9):837-45. Fried D, Featherstone JD, Le CQ, Fan K. PMID: 17044095.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    177. Remineralization of enamel caries can decrease optical reflectivity. J Dent Res. 2006 Sep; 85(9):804-8. Jones RS, Fried D. PMID: 16931861; PMCID: PMC2254215.
      View in: PubMed   Mentions: 50     Fields:    
    178. Light scattering properties of natural and artificially demineralized dental enamel at 1310 nm. J Biomed Opt. 2006 May-Jun; 11(3):34023. Darling CL, Huynh GD, Fried D. PMID: 16822072.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    179. Imaging artificial caries on the occlusal surfaces with polarization-sensitive optical coherence tomography. Caries Res. 2006; 40(2):81-9. Jones RS, Darling CL, Featherstone JD, Fried D. PMID: 16508263.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    180. Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography. J Biomed Opt. 2006 Jan-Feb; 11(1):014016. Jones RS, Darling CL, Featherstone JD, Fried D. PMID: 16526893.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    181. Early caries imaging and monitoring with near-infrared light. Dent Clin North Am. 2005 Oct; 49(4):771-93, vi. Fried D, Featherstone JD, Darling CL, Jones RS, Ngaotheppitak P, Bühler CM. PMID: 16150316.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    182. Measurement of the severity of natural smooth surface (interproximal) caries lesions with polarization sensitive optical coherence tomography. Lasers Surg Med. 2005 Jul; 37(1):78-88. Ngaotheppitak P, Darling CL, Fried D. PMID: 15889402.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    183. Imaging of occlusal dental caries (decay) with near-IR light at 1310-nm. Opt Express. 2005 Jan 24; 13(2):573-82. Bühler C, Ngaotheppitak P, Fried D. PMID: 19488387.
      View in: PubMed   Mentions: 64     Fields:    
    184. Selective removal of composite sealants with near-ultraviolet laser pulses of nanosecond duration. J Biomed Opt. 2005 Jan-Feb; 10(1):14001. Louie TM, Jones RS, Sarma AV, Fried D. PMID: 15847582.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    185. Transmission of Q-switched erbium:YSGG (lambda=2.79 microm) and erbium:YAG (lambda=2.94 microm) laser radiation through germanium oxide and sapphire optical fibres at high pulse energies. Lasers Med Sci. 2004; 19(3):155-60. Fried NM, Yang Y, Chaney CA, Fried D. PMID: 15645320.
      View in: PubMed   Mentions: 3     Fields:    
    186. Imaging artificial caries under composite sealants and restorations. J Biomed Opt. 2004 Nov-Dec; 9(6):1297-304. Jones RS, Staninec M, Fried D. PMID: 15568951.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    187. Pulpal safety of 9.6 microm TEA CO2 laser used for caries prevention. Lasers Surg Med. 2004; 35(2):104-10. Goodis HE, Fried D, Gansky S, Rechmann P, Featherstone JD. PMID: 15334612.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    188. Peripheral thermal and mechanical damage to dentin with microsecond and sub-microsecond 9.6 microm, 2.79 microm, and 0.355 microm laser pulses. Lasers Surg Med. 2004; 35(3):214-28. Dela Rosa A, Sarma AV, Le CQ, Jones RS, Fried D. PMID: 15389737.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    189. Selective targeting of protein, water, and mineral in dentin using UV and IR pulse lasers: the effect on the bond strength to composite restorative materials. Lasers Surg Med. 2004; 35(4):245-53. Sheth KK, Staninec M, Sarma AV, Fried D. PMID: 15493023.
      View in: PubMed   Mentions: 10     Fields:    
    190. Near-infrared transillumination at 1310-nm for the imaging of early dental decay. Opt Express. 2003 Sep 08; 11(18):2259-65. Jones R, Huynh G, Jones G, Fried D. PMID: 19466117.
      View in: PubMed   Mentions: 62     Fields:    
    191. Irradiation of dental enamel with Q-switched lambda = 355-nm laser pulses: surface morphology, fluoride adsorption, and adhesion to composite resin. Lasers Surg Med. 2003; 32(4):310-7. Wheeler CR, Fried D, Featherstone JD, Watanabe LG, Le CQ. PMID: 12696100.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    192. Influence of an optically thick water layer on the bond-strength of composite resin to dental enamel after IR laser ablation. Lasers Surg Med. 2003; 33(4):264-9. Staninec M, Xie J, Le CQ, Fried D. PMID: 14571452.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    193. Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography. J Biomed Opt. 2002 Oct; 7(4):618-27. Fried D, Xie J, Shafi S, Featherstone JD, Breunig TM, Le C. PMID: 12421130.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    194. Thermal and chemical modification of dentin by 9-11-microm CO2 laser pulses of 5-100-micros duration. Lasers Surg Med. 2002; 31(4):275-82. Fried D, Zuerlein MJ, Le CQ, Featherstone JD. PMID: 12355574.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    195. Selective ablation of surface enamel caries with a pulsed Nd:YAG dental laser. Lasers Surg Med. 2002; 30(5):342-50. Harris DM, White JM, Goodis H, Arcoria CJ, Simon J, Carpenter WM, Fried D, Burkart J, Yessik M, Myers T. PMID: 12116326.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    196. Selective removal of residual composite from dental enamel surfaces using the third harmonic of a Q-switched Nd:YAG laser. Lasers Surg Med. 2002; 30(3):240-5. Alexander R, Xie J, Fried D. PMID: 11891745.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    197. Mechanism of water augmentation during IR laser ablation of dental enamel. Lasers Surg Med. 2002; 31(3):186-93. Fried D, Ashouri N, Breunig T, Shori R. PMID: 12224092.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    198. Dental hard tissue modification and removal using sealed transverse excited atmospheric-pressure lasers operating at lambda=9.6 and 10.6 microm. J Biomed Opt. 2001 Apr; 6(2):231-8. Fried D, Ragadio J, Akrivou M, Featherstone JD, Murray MW, Dickenson KM. PMID: 11375734.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    199. Residual heat deposition in dental enamel during IR laser ablation at 2.79, 2.94, 9.6, and 10.6 microm. Lasers Surg Med. 2001; 29(3):221-9. Fried D, Ragadio J, Champion A. PMID: 11573223.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    200. Selective ablation of orthodontic composite by using sub-microsecond IR laser pulses with optical feedback. Lasers Surg Med. 2000; 27(2):103-10. Dumore T, Fried D. PMID: 10960816.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    201. Modeling the modification depth of carbon dioxide laser-treated dental enamel. Lasers Surg Med. 1999; 25(4):335-47. Zuerlein MJ, Fried D, Featherstone JD. PMID: 10534750.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    202. CO2 laser inhibitor of artificial caries-like lesion progression in dental enamel. J Dent Res. 1998 Jun; 77(6):1397-403. Featherstone JD, Barrett-Vespone NA, Fried D, Kantorowitz Z, Seka W. PMID: 9649168.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    203. Permanent and transient changes in the reflectance of CO2 laser-irradiated dental hard tissues at lambda = 9.3, 9.6, 10.3, and 10.6 microns and at fluences of 1-20 J/cm2. Lasers Surg Med. 1997; 20(1):22-31. Fried D, Glena RE, Featherstone JD, Seka W. PMID: 9041504.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
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