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    John Lynch, PhD

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentEpidemiology & Biostatistics
    Address550 16th. Street
    San Francisco CA 94158
    Phone415-514-8092
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Roemer FW, Guermazi A, Collins JE, Losina E, Nevitt MC, Lynch JA, Katz JN, Kwoh CK, Kraus VB, Hunter DJ. Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort?-?Methodologic aspects and definition of change. BMC Musculoskelet Disord. 2016 Nov 10; 17(1):466. PMID: 27832771.
        View in: PubMed
      2. Gersing AS, Schwaiger BJ, Heilmeier U, Joseph GB, Facchetti L, Kretzschmar M, Lynch JA, McCulloch CE, Nevitt MC, Steinbach LS, Link TM. Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative. Eur Radiol. 2016 Oct 4. PMID: 27704199.
        View in: PubMed
      3. Stefanik JJ, Gross KD, Guermazi A, Felson DT, Roemer FW, Niu J, Lynch JA, Segal NA, Lewis CE, Lewis CL. Relation of Step Length to Magnetic Resonance Imaging-Detected Structural Damage in the Patellofemoral Joint: The Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). 2016 Jun; 68(6):776-83. PMID: 26413842.
        View in: PubMed
      4. Driban JB, Price LL, Lynch J, Nevitt M, Lo GH, Eaton CB, McAlindon TE. Defining and evaluating a novel outcome measure representing end-stage knee osteoarthritis: data from the Osteoarthritis Initiative. Clin Rheumatol. 2016 May 16. PMID: 27184045.
        View in: PubMed
      5. Podsiadlo P, Nevitt MC, Wolski M, Stachowiak GW, Lynch JA, Tolstykh I, Felson DT, Segal NA, Lewis CE, Englund M. Baseline trabecular bone and its relation to incident radiographic knee osteoarthritis and increase in joint space narrowing score: directional fractal signature analysis in the MOST study. Osteoarthritis Cartilage. 2016 May 7. PMID: 27163445.
        View in: PubMed
      6. Collins JE, Losina E, Nevitt MC, Roemer FW, Guermazi A, Lynch JA, Katz JN, Kwoh CK, Kraus VB, Hunter DJ. Semi-Quantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data from the FNIH OA Biomarkers Consortium. Arthritis Rheumatol. 2016 Apr 25. PMID: 27111771.
        View in: PubMed
      7. Wise BL, Liu F, Kritikos L, Lynch JA, Parimi N, Zhang Y, Lane NE. The association of distal femur and proximal tibia shape with sex: The Osteoarthritis Initiative. Semin Arthritis Rheum. 2016 Mar 3. PMID: 27039962.
        View in: PubMed
      8. Nelson AE, Golightly YM, Renner JB, Schwartz TA, Liu F, Lynch JA, Gregory JS, Aspden RM, Lane NE, Jordan JM. Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. J Rheumatol. 2016 Feb; 43(2):405-10. PMID: 26669914.
        View in: PubMed
      9. Eckstein F, Collins JE, Nevitt MC, Lynch JA, Kraus VB, Katz JN, Losina E, Wirth W, Guermazi A, Roemer FW, Hunter DJ. Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. Arthritis Rheumatol. 2015 Dec; 67(12):3184-9. PMID: 26316262.
        View in: PubMed
      10. An H, Marron JS, Schwartz TA, Renner JB, Liu F, Lynch JA, Lane NE, Jordan JM, Nelson AE. Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage. 2016 Apr; 24(4):640-6. PMID: 26620089.
        View in: PubMed
      11. Joseph GB, Hilton JF, Jungmann PM, Lynch JA, Lane NE, Liu F, McCulloch CE, Tolstykh I, Link TM, Nevitt MC. Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Mar; 24(3):427-35. PMID: 26497607.
        View in: PubMed
      12. Hunter D, Nevitt M, Lynch J, Kraus VB, Katz JN, Collins JE, Bowes M, Guermazi A, Roemer FW, Losina E. Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis. 2015 Oct 19. PMID: 26483253.
        View in: PubMed
      13. Kretzschmar M, Lin W, Nardo L, Joseph GB, Dunlop DD, Heilmeier U, Nevitt MC, Alizai H, McCulloch CE, Lynch JA, Link TM. Association of Physical Activity Measured by Accelerometer, Knee Joint Abnormalities, and Cartilage T2 Measurements Obtained From 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2015 Sep; 67(9):1272-80. PMID: 25777255.
        View in: PubMed
      14. Jarraya M, Guermazi A, Niu J, Duryea J, Lynch JA, Roemer FW. Multi-dimensional reliability assessment of fractal signature analysis in an outpatient sports medicine population. Ann Anat. 2015 Nov; 202:57-60. PMID: 26343866.
        View in: PubMed
      15. Segal NA, Nevitt MC, Lynch JA, Niu J, Torner JC, Guermazi A. Diagnostic performance of 3D standing CT imaging for detection of knee osteoarthritis features. Phys Sportsmed. 2015 Aug 3; 1-8. PMID: 26235750.
        View in: PubMed
      16. Segal NA, Nevitt MC, Lynch JA, Niu J, Torner JC, Guermazi A. Diagnostic performance of 3D standing CT imaging for detection of knee osteoarthritis features. Phys Sportsmed. 2015 Jul; 43(3):213-20. PMID: 26313455.
        View in: PubMed
      17. Roemer FW, Jarraya M, Niu J, Duryea J, Lynch JA, Guermazi A. Knee joint subchondral bone structure alterations in active athletes: a cross-sectional case-control study. Osteoarthritis Cartilage. 2015 Dec; 23(12):2184-90. PMID: 26187571.
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      18. Sheehy L, Culham E, McLean L, Niu J, Lynch J, Segal NA, Singh JA, Nevitt M, Cooke TD. Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis Study (MOST). Osteoarthritis Cartilage. 2015 Sep; 23(9):1491-8. PMID: 26003948.
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      19. Guermazi A, Hayashi D, Roemer F, Felson DT, Wang K, Lynch J, Amin S, Torner J, Lewis CE, Nevitt MC. Severe radiographic knee osteoarthritis--does Kellgren and Lawrence grade 4 represent end stage disease?--the MOST study. Osteoarthritis Cartilage. 2015 Sep; 23(9):1499-505. PMID: 25929973; PMCID: PMC4558267 [Available on 09/01/16].
      20. Joseph GB, McCulloch CE, Nevitt MC, Heilmeier U, Nardo L, Lynch JA, Liu F, Baum T, Link TM. A reference database of cartilage 3 T MRI T2 values in knees without diagnostic evidence of cartilage degeneration: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2015 Jun; 23(6):897-905. PMID: 25680652; PMCID: PMC4444394 [Available on 06/01/16].
      21. Bucknor MD, Nardo L, Joseph GB, Alizai H, Srikhum W, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2015 Apr; 23(4):525-31. PMID: 25591445; PMCID: PMC4368476 [Available on 04/01/16].
      22. Misra D, Guermazi A, Sieren JP, Lynch J, Torner J, Neogi T, Felson DT. CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage. 2015 Feb; 23(2):244-8. PMID: 25451303; PMCID: PMC4305039 [Available on 02/01/16].
      23. Iranpour-Boroujeni T, Li J, Lynch JA, Nevitt M, Duryea J. A new method to measure anatomic knee alignment for large studies of OA: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2014 Oct; 22(10):1668-74. PMID: 25278076.
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      24. Crema MD, Nevitt MC, Guermazi A, Felson DT, Wang K, Lynch JA, Marra MD, Torner J, Lewis CE, Roemer FW. Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA--the MOST study. Osteoarthritis Cartilage. 2014 Oct; 22(10):1743-7. PMID: 25278083; PMCID: PMC4187213.
      25. Wise BL, Kritikos L, Lynch JA, Liu F, Parimi N, Tileston KL, Nevitt MC, Lane NE. Proximal femur shape differs between subjects with lateral and medial knee osteoarthritis and controls: the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Dec; 22(12):2067-73. PMID: 25194496; PMCID: PMC4252863 [Available on 12/01/15].
      26. Lee S, Nardo L, Kumar D, Wyatt CR, Souza RB, Lynch J, McCulloch CE, Majumdar S, Lane NE, Link TM. Scoring hip osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system. J Magn Reson Imaging. 2015 Jun; 41(6):1549-57. PMID: 25139720; PMCID: PMC4336224 [Available on 06/01/16].
      27. Boissonneault A, Lynch JA, Wise BL, Segal NA, Gross KD, Murray DW, Nevitt MC, Pandit HG. Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST). Osteoarthritis Cartilage. 2014 Aug; 22(8):1129-35. PMID: 24971867; PMCID: PMC4195737.
      28. Serebrakian AT, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative. J Magn Reson Imaging. 2015 May; 41(5):1272-80. PMID: 24700497; PMCID: PMC4185274 [Available on 05/01/16].
      29. Liebl H, Joseph G, Nevitt MC, Singh N, Heilmeier U, Subburaj K, Jungmann PM, McCulloch CE, Lynch JA, Lane NE, Link TM. Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative. Ann Rheum Dis. 2015 Jul; 74(7):1353-9. PMID: 24615539; PMCID: PMC4160419 [Available on 01/01/16].
      30. Alizai H, Virayavanich W, Joseph GB, Nardo L, Liu F, Liebl H, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Cartilage lesion score: comparison of a quantitative assessment score with established semiquantitative MR scoring systems. Radiology. 2014 May; 271(2):479-87. PMID: 24475848; PMCID: PMC4263635.
      31. Guermazi A, Hayashi D, Roemer FW, Zhu Y, Niu J, Crema MD, Javaid MK, Marra MD, Lynch JA, El-Khoury GY, Zhang Y, Nevitt MC, Felson DT. Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study. J Rheumatol. 2014 Mar; 41(3):501-8. PMID: 24429179.
        View in: PubMed
      32. Nelson AE, Liu F, Lynch JA, Renner JB, Schwartz TA, Lane NE, Jordan JM. Association of incident symptomatic hip osteoarthritis with differences in hip shape by active shape modeling: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken). 2014 Jan; 66(1):74-81. PMID: 23926053; PMCID: PMC3959908.
      33. Jungmann PM, Kraus MS, Alizai H, Nardo L, Baum T, Nevitt MC, McCulloch CE, Joseph GB, Lynch JA, Link TM. Association of metabolic risk factors with cartilage degradation assessed by T2 relaxation time at the knee: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2013 Dec; 65(12):1942-50. PMID: 23926027; PMCID: PMC4144858.
      34. Wirth W, Nevitt M, Hellio Le Graverand MP, Lynch J, Maschek S, Hudelmaier M, Eckstein F. Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment--data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Jan; 22(1):63-70. PMID: 24185111; PMCID: PMC4054605.
      35. Jungmann PM, Kraus MS, Nardo L, Liebl H, Alizai H, Joseph GB, Liu F, Lynch J, McCulloch CE, Nevitt MC, Link TM. T(2) relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: longitudinal data from the osteoarthritis initiative. J Magn Reson Imaging. 2013 Dec; 38(6):1415-24. PMID: 24038491; PMCID: PMC4114220.
      36. Virayavanich W, Alizai H, Baum T, Nardo L, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Association of frequent knee bending activity with focal knee lesions detected with 3T magnetic resonance imaging: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2013 Sep; 65(9):1441-8. PMID: 23554229; PMCID: PMC4118638.
      37. Lin W, Alizai H, Joseph GB, Srikhum W, Nevitt MC, Lynch JA, McCulloch CE, Link TM. Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2013 Oct; 21(10):1558-66. PMID: 23831632; PMCID: PMC3874212.
      38. Jungmann PM, Tham SC, Liebl H, Nevitt MC, McCulloch CE, Lynch J, Link TM. Association of trochlear dysplasia with degenerative abnormalities in the knee: data from the Osteoarthritis Initiative. Skeletal Radiol. 2013 Oct; 42(10):1383-92. PMID: 23801099; PMCID: PMC3757255.
      39. Guermazi A, Hayashi D, Jarraya M, Roemer FW, Zhang Y, Niu J, Crema MD, Englund M, Lynch JA, Nevitt MC, Torner JC, Lewis CE, Felson DT. Medial posterior meniscal root tears are associated with development or worsening of medial tibiofemoral cartilage damage: the multicenter osteoarthritis study. Radiology. 2013 Sep; 268(3):814-21. PMID: 23696679; PMCID: PMC3750419.
      40. Stefanik JJ, Zumwalt AC, Segal NA, Lynch JA, Powers CM. Association between measures of patella height, morphologic features of the trochlea, and patellofemoral joint alignment: the MOST study. Clin Orthop Relat Res. 2013 Aug; 471(8):2641-8. PMID: 23546847; PMCID: PMC3705075.
      41. Chundru R, Baum T, Nardo L, Nevitt MC, Lynch J, McCulloch CE, Link TM. Focal knee lesions in knee pairs of asymptomatic and symptomatic subjects with OA risk factors--data from the Osteoarthritis Initiative. Eur J Radiol. 2013 Aug; 82(8):e367-73. PMID: 23540944; PMCID: PMC3696431.
      42. Pang J, Driban JB, Destenaves G, Miller E, Lo GH, Ward RJ, Price LL, Lynch JA, Eaton CB, Eckstein F, McAlindon TE. Quantification of bone marrow lesion volume and volume change using semi-automated segmentation: data from the osteoarthritis initiative. BMC Musculoskelet Disord. 2013; 14:3. PMID: 23281825; PMCID: PMC3637109.
      43. Baum T, Joseph GB, Nardo L, Virayavanich W, Arulanandan A, Alizai H, Carballido-Gamio J, Nevitt MC, Lynch J, McCulloch CE, Link TM. Correlation of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with body mass index: thirty-six-month followup data from a longitudinal, observational multicenter study. Arthritis Care Res (Hoboken). 2013 Jan; 65(1):23-33. PMID: 22623435; PMCID: PMC3432679.
      44. Driban JB, Price L, Lo GH, Pang J, Hunter DJ, Miller E, Ward RJ, Eaton CB, Lynch JA, McAlindon TE. Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker--longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative. Arthritis Res Ther. 2013; 15(5):R112. PMID: 24020939; PMCID: PMC3978948.
      45. Driban JB, Lo GH, Price L, Pang J, Miller E, Ward RJ, Hunter DJ, Eaton CB, Lynch JA, McAlindon TE. Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative. Arthritis Res Ther. 2013; 15(5):R153. PMID: 24432365; PMCID: PMC3978480.
      46. Crema MD, Felson DT, Roemer FW, Niu J, Marra MD, Zhang Y, Lynch JA, El-Khoury GY, Lewis CE, Guermazi A. Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The MOST study. Osteoarthritis Cartilage. 2013 Mar; 21(3):413-8. PMID: 23277189; PMCID: PMC3578385.
      47. Roemer FW, Felson DT, Yang T, Niu J, Crema MD, Englund M, Nevitt MC, Zhang Y, Lynch JA, El Khoury GY, Torner J, Lewis CE, Guermazi A. The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study. Semin Arthritis Rheum. 2013 Jun; 42(6):573-81. PMID: 23270763; PMCID: PMC3640766.
      48. Crema MD, Felson DT, Roemer FW, Wang K, Marra MD, Nevitt MC, Lynch JA, Torner J, Lewis CE, Guermazi A. Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study. Osteoarthritis Cartilage. 2013 Feb; 21(2):306-13. PMID: 23178289; PMCID: PMC3556203.
      49. Anderson DD, Segal NA, Kern AM, Nevitt MC, Torner JC, Lynch JA. Reliability of semiautomated computational methods for estimating tibiofemoral contact stress in the Multicenter Osteoarthritis Study. Comput Math Methods Med. 2012; 2012:767469. PMID: 23097679; PMCID: PMC3477762.
      50. Nardo L, Alizai H, Virayavanich W, Liu F, Hernandez A, Lynch JA, Nevitt MC, McCulloch CE, Lane NE, Link TM. Lumbosacral transitional vertebrae: association with low back pain. Radiology. 2012 Nov; 265(2):497-503. PMID: 22952380; PMCID: PMC3480814.
      51. Driban JB, Tassinari A, Lo GH, Price LL, Schneider E, Lynch JA, Eaton CB, McAlindon TE. Bone marrow lesions are associated with altered trabecular morphometry. Osteoarthritis Cartilage. 2012 Dec; 20(12):1519-26. PMID: 22940708; PMCID: PMC3478500.
      52. Roemer FW, Nevitt MC, Felson DT, Niu J, Lynch JA, Crema MD, Lewis CE, Torner J, Guermazi A. Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint--the MOST study. Osteoarthritis Cartilage. 2012 Nov; 20(11):1391-8. PMID: 22846715; PMCID: PMC3863692.
      53. Eckstein F, Mc Culloch CE, Lynch JA, Nevitt M, Kwoh CK, Maschek S, Hudelmaier M, Sharma L, Wirth W. How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2012 Nov; 20(11):1250-7. PMID: 22800771; PMCID: PMC3471368.
      54. Segal NA, Kern AM, Anderson DD, Niu J, Lynch J, Guermazi A, Torner JC, Brown TD, Nevitt M. Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months. Osteoarthritis Cartilage. 2012 Oct; 20(10):1120-6. PMID: 22698440; PMCID: PMC3427397.
      55. Sharma L, Chmiel JS, Almagor O, Felson D, Guermazi A, Roemer F, Lewis CE, Segal N, Torner J, Cooke TD, Hietpas J, Lynch J, Nevitt M. The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study. Ann Rheum Dis. 2013 Feb; 72(2):235-40. PMID: 22550314; PMCID: PMC3845483.
      56. Baker-Lepain JC, Lynch JA, Parimi N, McCulloch CE, Nevitt MC, Corr M, Lane NE. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum. 2012 May; 64(5):1457-65. PMID: 22544526; PMCID: PMC3340442.
      57. Joseph GB, Baum T, Alizai H, Carballido-Gamio J, Nardo L, Virayavanich W, Lynch JA, Nevitt MC, McCulloch CE, Majumdar S, Link TM. Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years--data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2012 Jul; 20(7):727-35. PMID: 22503812; PMCID: PMC3595156.
      58. Baum T, Joseph GB, Arulanandan A, Nardo L, Virayavanich W, Carballido-Gamio J, Nevitt MC, Lynch J, McCulloch CE, Link TM. Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2012 Feb; 64(2):248-55. PMID: 22012846; PMCID: PMC3267009.
      59. Baum T, Stehling C, Joseph GB, Carballido-Gamio J, Schwaiger BJ, Müller-Höcker C, Nevitt MC, Lynch J, McCulloch CE, Link TM. Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: data from the osteoarthritis initiative. J Magn Reson Imaging. 2012 Feb; 35(2):370-8. PMID: 21987496; PMCID: PMC3265616.
      60. Stefanik JJ, Guermazi A, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Segal NA, Lewis CE, Roemer FW, Powers CM, Felson DT. Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis. Arthritis Care Res (Hoboken). 2011 Oct; 63(10):1391-7. PMID: 21702087; PMCID: PMC3183313.
      61. Joseph GB, Baum T, Carballido-Gamio J, Nardo L, Virayavanich W, Alizai H, Lynch JA, McCulloch CE, Majumdar S, Link TM. Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls--data from the osteoarthritis initiative. Arthritis Res Ther. 2011; 13(5):R153. PMID: 21933394; PMCID: PMC3308083.
      62. Laberge MA, Baum T, Virayavanich W, Nardo L, Nevitt MC, Lynch J, McCulloch CE, Link TM. Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects--data from the Osteoarthritis Initiative. Skeletal Radiol. 2012 Jun; 41(6):633-41. PMID: 21887596; PMCID: PMC4105189.
      63. Hovis KK, Stehling C, Souza RB, Haughom BD, Baum T, Nevitt M, McCulloch C, Lynch JA, Link TM. Physical activity is associated with magnetic resonance imaging-based knee cartilage T2 measurements in asymptomatic subjects with and those without osteoarthritis risk factors. Arthritis Rheum. 2011 Aug; 63(8):2248-56. PMID: 21538328; PMCID: PMC3149726.
      64. Roemer FW, Guermazi A, Felson DT, Niu J, Nevitt MC, Crema MD, Lynch JA, Lewis CE, Torner J, Zhang Y. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis. 2011 Oct; 70(10):1804-9. PMID: 21791448; PMCID: PMC3496084.
      65. Stefanik JJ, Roemer FW, Zumwalt AC, Zhu Y, Gross KD, Lynch JA, Frey-Law LA, Lewis CE, Guermazi A, Powers CM, Felson DT. Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: the MOST study. J Orthop Res. 2012 Jan; 30(1):1-8. PMID: 21710542; PMCID: PMC3217080.
      66. Englund M, Felson DT, Guermazi A, Roemer FW, Wang K, Crema MD, Lynch JA, Sharma L, Segal NA, Lewis CE, Nevitt MC. Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study. Ann Rheum Dis. 2011 Oct; 70(10):1733-9. PMID: 21646417.
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      67. Baker-LePain JC, Luker KR, Lynch JA, Parimi N, Nevitt MC, Lane NE. Active shape modeling of the hip in the prediction of incident hip fracture. J Bone Miner Res. 2011 Mar; 26(3):468-74. PMID: 20878772; PMCID: PMC3179295.
      68. Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, Marra MD, Katur A, Lynch JA, El-Khoury GY, Baker K, Hughes LB, Nevitt MC, Felson DT. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis. 2011 May; 70(5):805-11. PMID: 21187293; PMCID: PMC4180232.
      69. Carballido-Gamio J, Joseph GB, Lynch JA, Link TM, Majumdar S. Longitudinal analysis of MRI T2 knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative: a texture approach. Magn Reson Med. 2011 Apr; 65(4):1184-94. PMID: 21413082.
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      70. Pan J, Stehling C, Muller-Hocker C, Schwaiger BJ, Lynch J, McCulloch CE, Nevitt MC, Link TM. Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2011 Jan; 19(1):65-73. PMID: 21044692; PMCID: PMC3027210.
      71. Sheehy L, Felson D, Zhang Y, Niu J, Lam YM, Segal N, Lynch J, Cooke TD. Does measurement of the anatomic axis consistently predict hip-knee-ankle angle (HKA) for knee alignment studies in osteoarthritis? Analysis of long limb radiographs from the multicenter osteoarthritis (MOST) study. Osteoarthritis Cartilage. 2011 Jan; 19(1):58-64. PMID: 20950695; PMCID: PMC3038654.
      72. Felson DT, Lynch J, Guermazi A, Roemer FW, Niu J, McAlindon T, Nevitt MC. Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2010 Nov; 18(11):1402-7. PMID: 20851202; PMCID: PMC3005331.
      73. Guermazi A, Hayashi D, Roemer FW, Niu J, Yang M, Lynch JA, Torner JC, Lewis CE, Sack B, Felson DT, Nevitt MC. Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study. Osteoarthritis Cartilage. 2010 Nov; 18(11):1386-92. PMID: 20816978; PMCID: PMC2975853.
      74. Lynch JA, Roemer FW, Nevitt MC, Felson DT, Niu J, Eaton CB, Guermazi A. Comparison of BLOKS and WORMS scoring systems part I. Cross sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2010 Nov; 18(11):1393-401. PMID: 20816979; PMCID: PMC3055245.
      75. Stefanik JJ, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Frey Law LA, Lewis CE, Roemer FW, Powers CM, Guermazi A, Felson DT. Association between patella alta and the prevalence and worsening of structural features of patellofemoral joint osteoarthritis: the multicenter osteoarthritis study. Arthritis Care Res (Hoboken). 2010 Sep; 62(9):1258-65. PMID: 20506169; PMCID: PMC2943040.
      76. Crema MD, Roemer FW, Zhu Y, Marra MD, Niu J, Zhang Y, Lynch JA, Javaid MK, Lewis CE, El-Khoury GY, Felson DT, Guermazi A. Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging--the MOST study. Radiology. 2010 Sep; 256(3):855-62. PMID: 20530753; PMCID: PMC2923728.
      77. Sharma L, Song J, Dunlop D, Felson D, Lewis CE, Segal N, Torner J, Cooke TD, Hietpas J, Lynch J, Nevitt M. Varus and valgus alignment and incident and progressive knee osteoarthritis. Ann Rheum Dis. 2010 Nov; 69(11):1940-5. PMID: 20511608; PMCID: PMC2994600.
      78. Anderson DD, Iyer KS, Segal NA, Lynch JA, Brown TD. Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure. J Appl Biomech. 2010 May; 26(2):215-23. PMID: 20498493; PMCID: PMC2905528.
      79. Englund M, Guermazi A, Roemer FW, Yang M, Zhang Y, Nevitt MC, Lynch JA, Lewis CE, Torner J, Felson DT. Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Ann Rheum Dis. 2010 Oct; 69(10):1796-802. PMID: 20421344; PMCID: PMC2966967.
      80. Stehling C, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative. Osteoarthritis Cartilage. 2010 Jun; 18(6):776-86. PMID: 20202488.
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      81. Carballido-Gamio J, Blumenkrantz G, Lynch JA, Link TM, Majumdar S. Longitudinal analysis of MRI T(2) knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative. Magn Reson Med. 2010 Feb; 63(2):465-72. PMID: 19918905.
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      82. Stehling C, Liebl H, Krug R, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology. 2010 Feb; 254(2):509-20. PMID: 20019141; PMCID: PMC2809928.
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      84. Neogi T, Felson D, Niu J, Lynch J, Nevitt M, Guermazi A, Roemer F, Lewis CE, Wallace B, Zhang Y. Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study. Arthritis Rheum. 2009 Nov 15; 61(11):1539-44. PMID: 19877101; PMCID: PMC2789549.
      85. Javaid MK, Lynch JA, Tolstykh I, Guermazi A, Roemer F, Aliabadi P, McCulloch C, Curtis J, Felson D, Lane NE, Torner J, Nevitt M. Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study. Osteoarthritis Cartilage. 2010 Mar; 18(3):323-8. PMID: 19919856; PMCID: PMC2990960.
      86. Crema MD, Roemer FW, Marra MD, Niu J, Lynch JA, Felson DT, Guermazi A. Contrast-enhanced MRI of subchondral cysts in patients with or at risk for knee osteoarthritis: the MOST study. Eur J Radiol. 2010 Jul; 75(1):e92-6. PMID: 19767165; PMCID: PMC2891222.
      87. Roemer FW, Neogi T, Nevitt MC, Felson DT, Zhu Y, Zhang Y, Lynch JA, Javaid MK, Crema MD, Torner J, Lewis CE, Guermazi A. Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage. 2010 Jan; 18(1):47-53. PMID: 19769930; PMCID: PMC2818146.
      88. Roemer FW, Lynch JA, Niu J, Zhang Y, Crema MD, Tolstykh I, El-Khoury GY, Felson DT, Lewis CE, Nevitt MC, Guermazi A. A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study. Osteoarthritis Cartilage. 2010 Feb; 18(2):168-74. PMID: 19766580; PMCID: PMC2818134.
      89. Roemer FW, Zhang Y, Niu J, Lynch JA, Crema MD, Marra MD, Nevitt MC, Felson DT, Hughes LB, El-Khoury GY, Englund M, Guermazi A. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology. 2009 Sep; 252(3):772-80. PMID: 19635831; PMCID: PMC2734891.
      90. Lynch JA, Parimi N, Chaganti RK, Nevitt MC, Lane NE. The association of proximal femoral shape and incident radiographic hip OA in elderly women. Osteoarthritis Cartilage. 2009 Oct; 17(10):1313-8. PMID: 19427402; PMCID: PMC3678721.
      91. Lo GH, Hunter DJ, Nevitt M, Lynch J, McAlindon TE. Strong association of MRI meniscal derangement and bone marrow lesions in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2009 Jun; 17(6):743-7. PMID: 19097919; PMCID: PMC2771759.
      92. Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, Javaid MK, Lynch JA, Mohr A, Torner J, Lewis CE, Nevitt MC, Felson DT. The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage. 2009 Jun; 17(6):748-53. PMID: 19008123; PMCID: PMC2740855.
      93. Roemer FW, Guermazi A, Javaid MK, Lynch JA, Niu J, Zhang Y, Felson DT, Lewis CE, Torner J, Nevitt MC. Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis. Ann Rheum Dis. 2009 Sep; 68(9):1461-5. PMID: 18829615; PMCID: PMC2905622.
      94. Englund M, Niu J, Guermazi A, Roemer FW, Hunter DJ, Lynch JA, Lewis CE, Torner J, Nevitt MC, Zhang YQ, Felson DT. Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness. Arthritis Rheum. 2007 Dec; 56(12):4048-54. PMID: 18050201.
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      95. Roemer FW, Mohr A, Lynch JA, Meta MD, Guermazi A, Genant HK. Micro-CT arthrography: a pilot study for the ex vivo visualization of the rat knee joint. AJR Am J Roentgenol. 2005 Apr; 184(4):1215-9. PMID: 15788597.
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      96. Roemer FW, Guermazi A, Lynch JA, Peterfy CG, Nevitt MC, Webb N, Li J, Mohr A, Genant HK, Felson DT. Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol. Eur Radiol. 2005 May; 15(5):978-87. PMID: 15633060.
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      97. Carano RA, Lynch JA. Quantification of bone lesions in rheumatoid arthritis by MRI multispectral tissue class transition analysis. Semin Musculoskelet Radiol. 2004 Dec; 8(4):301-11. PMID: 15643571.
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      98. Guermazi A, Taouli B, Lynch JA, Peterfy CG. Imaging of bone erosion in rheumatoid arthritis. Semin Musculoskelet Radiol. 2004 Dec; 8(4):269-85. PMID: 15643569.
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      99. Mohr A, Wenke R, Roemer FW, Lynch JA, Gatzka C, Priebe M, Guermazi A, Grigorian M, Heller M, Mueller-Huelsbeck S. Micro-CT of carotid arteries: a tool for experimental studies. Cardiovasc Intervent Radiol. 2004 Nov-Dec; 27(6):651-4. PMID: 15593429.
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      100. Jiang Y, Zhao J, Geusens P, Liao EY, Adriaensens P, Gelan J, Azria M, Boonen S, Caulin F, Lynch JA, Ouyang X, Genant HK. Femoral neck trabecular microstructure in ovariectomized ewes treated with calcitonin: MRI microscopic evaluation. J Bone Miner Res. 2005 Jan; 20(1):125-30. PMID: 15619678.
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      101. Carano RA, Lynch JA, Redei J, Ostrowitzki S, Miaux Y, Zaim S, White DL, Peterfy CG, Genant HK. Multispectral analysis of bone lesions in the hands of patients with rheumatoid arthritis. Magn Reson Imaging. 2004 May; 22(4):505-14. PMID: 15120170.
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      102. Taouli B, Zaim S, Peterfy CG, Lynch JA, Stork A, Guermazi A, Fan B, Fye KH, Genant HK. Rheumatoid arthritis of the hand and wrist: comparison of three imaging techniques. AJR Am J Roentgenol. 2004 Apr; 182(4):937-43. PMID: 15039167.
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      103. Lynch JA, Grigoryan M, Fierlinger A, Guermazi A, Zaim S, MacLean DB, Genant HK. Measurement of changes in trabecular bone at fracture sites using X-ray CT and automated image registration and processing. J Orthop Res. 2004 Mar; 22(2):362-7. PMID: 15013097.
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      104. Ostrowitzki S, Rédei J, Lynch JA, Carano RA, Zaim S, Miaux Y, Genant HK. Use of multispectral magnetic resonance imaging analysis to quantify erosive changes in the hands of patients with rheumatoid arthritis: short-term and long-term longitudinal studies. Arthritis Rheum. 2004 Mar; 50(3):716-24. PMID: 15022310.
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      105. Grigoryan M, Lynch JA, Fierlinger AL, Guermazi A, Fan B, MacLean DB, MacLean A, Genant HK. Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography. Acad Radiol. 2003 Nov; 10(11):1267-73. PMID: 14626301.
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      106. Mohr A, Heiss C, Bergmann I, Schrader C, Roemer FW, Lynch JA, Muhle C, Genant HK, Heller M. Value of micro-CT as an investigative tool for osteochondritis dissecans. Acta Radiol. 2003 Sep; 44(5):532-7. PMID: 14510761.
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      107. Duryea J, Dobbins JT, Lynch JA. Digital tomosynthesis of hand joints for arthritis assessment. Med Phys. 2003 Mar; 30(3):325-33. PMID: 12674232.
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      108. Peterfy C, Li J, Zaim S, Duryea J, Lynch J, Miaux Y, Yu W, Genant HK. Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol. 2003 Mar; 32(3):128-32. PMID: 12605275.
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      109. Buckland-Wright JC, Lynch JA, Dave B. Early radiographic features in patients with anterior cruciate ligament rupture. Ann Rheum Dis. 2000 Aug; 59(8):641-6. PMID: 10913063; PMCID: PMC1753209.
      110. Rhodes JS, Ford TR, Lynch JA, Liepins PJ, Curtis RV. A comparison of two nickel-titanium instrumentation techniques in teeth using microcomputed tomography. Int Endod J. 2000 May; 33(3):279-85. PMID: 11307448.
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      111. Mazzuca SA, Brandt KD, Buckland-Wright JC, Buckwalter KA, Katz BP, Lynch JA, Ward RJ, Emsley CL. Field test of the reproducibility of automated measurements of medial tibiofemoral joint space width derived from standardized knee radiographs. J Rheumatol. 1999 Jun; 26(6):1359-65. PMID: 10381056.
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      112. Rhodes JS, Ford TR, Lynch JA, Liepins PJ, Curtis RV. Micro-computed tomography: a new tool for experimental endodontology. Int Endod J. 1999 May; 32(3):165-70. PMID: 10530203.
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      113. Buckland-Wright JC, Lynch JA, Bird C. Microfocal techniques in quantitative radiography: measurement of cancellous bone organization. Br J Rheumatol. 1996 Dec; 35 Suppl 3:18-22. PMID: 9010084.
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      114. Buckland-Wright JC, Lynch JA, Macfarlane DG. Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis. Ann Rheum Dis. 1996 Oct; 55(10):749-55. PMID: 8984941; PMCID: PMC1010294.
      115. Buckland-Wright JC, Macfarlane DG, Lynch JA. Sensitivity of radiographic features and specificity of scintigraphic imaging in hand osteoarthritis. Rev Rhum Engl Ed. 1995 Jun; 62(6 Suppl 1):14S-26S. PMID: 7583178.
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      116. Buckland-Wright JC, MacFarlane DG, Lynch JA, Jasani MK. Quantitative microfocal radiography detects changes in OA knee joint space width in patients in placebo controlled trial of NSAID therapy. J Rheumatol. 1995 May; 22(5):937-43. PMID: 8587086.
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      117. Buckland-Wright JC, Macfarlane DG, Lynch JA, Jasani MK, Bradshaw CR. Joint space width measures cartilage thickness in osteoarthritis of the knee: high resolution plain film and double contrast macroradiographic investigation. Ann Rheum Dis. 1995 Apr; 54(4):263-8. PMID: 7763102; PMCID: PMC1005571.
      118. Buckland-Wright JC, Macfarlane DG, Jasani MK, Lynch JA. Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views. J Rheumatol. 1994 Sep; 21(9):1734-41. PMID: 7799359.
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      119. Buckland-Wright JC, Lynch JA, Rymer J, Fogelman I. Fractal signature analysis of macroradiographs measures trabecular organization in lumbar vertebrae of postmenopausal women. Calcif Tissue Int. 1994 Feb; 54(2):106-12. PMID: 8012865.
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      120. Macfarlane DG, Buckland-Wright JC, Lynch J, Fogelman I. A study of the early and late 99technetium scintigraphic images and their relationship to symptoms in osteoarthritis of the hands. Br J Rheumatol. 1993 Nov; 32(11):977-81. PMID: 8220937.
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      121. Lynch JA, Buckland-Wright JC, Macfarlane DG. Precision of joint space width measurement in knee osteoarthritis from digital image analysis of high definition macroradiographs. Osteoarthritis Cartilage. 1993 Oct; 1(4):209-18. PMID: 15449508.
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      122. Buckland-Wright JC, Macfarlane DG, Lynch JA. Microfocal radiography with macroradiographs in osteoarthritis. J Rheumatol. 1993 Jun; 20(6):1084-5. PMID: 8350320.
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      123. Dyson M, Young SR, Hart J, Lynch JA, Lang S. Comparison of the effects of moist and dry conditions on the process of angiogenesis during dermal repair. J Invest Dermatol. 1992 Dec; 99(6):729-33. PMID: 1281862.
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      124. Buckland-Wright JC, MacFarlane DG, Lynch JA. Relationship between joint space width and subchondral sclerosis in the osteoarthritic hand: a quantitative microfocal radiographic study. J Rheumatol. 1992 May; 19(5):788-95. PMID: 1613711.
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      125. Buckland-Wright JC, Macfarlane DG, Lynch JA. Osteophytes in the osteoarthritic hand: their incidence, size, distribution, and progression. Ann Rheum Dis. 1991 Sep; 50(9):627-30. PMID: 1929585; PMCID: PMC1004506.
      126. Macfarlane DG, Buckland-Wright JC, Emery P, Fogelman I, Clark B, Lynch J. Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of the hands. Ann Rheum Dis. 1991 Sep; 50(9):623-6. PMID: 1929584; PMCID: PMC1004505.
      127. Lynch JA, Hawkes DJ, Buckland-Wright JC. Analysis of texture in macroradiographs of osteoarthritic knees using the fractal signature. Phys Med Biol. 1991 Jun; 36(6):709-22. PMID: 1871209.
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      128. Lynch JA, Hawkes DJ, Buckland-Wright JC. A robust and accurate method for calculating the fractal signature of texture in macroradiographs of osteoarthritic knees. Med Inform (Lond). 1991 Apr-Jun; 16(2):241-51. PMID: 1921566.
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      129. Buckland-Wright JC, Macfarlane DG, Fogelman I, Emery P, Lynch JA. Techetium 99m methylene diphosphonate bone scanning in osteoarthritic hands. Eur J Nucl Med. 1991; 18(1):12-6. PMID: 2019277.
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      130. Buckland-Wright JC, Macfarlane DG, Lynch JA, Clark B. Quantitative microfocal radiographic assessment of progression in osteoarthritis of the hand. Arthritis Rheum. 1990 Jan; 33(1):57-65. PMID: 2302268.
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