Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Patrick O'Farrell, PhD

    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th Street
    San Francisco CA 94158
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      We are interested in the decoding of biological information to produce functional structures at the level of cells and organisms. We focus on the control of the cell cycle during development using Drosophila genetics, molecular biology and fancy microscopy. We are examining temporal coordination of early embryonic cell cycles with development. Having found that slowing early rapid cell cycles is due to prolongation of S phase, the period of DNA replication, we are studying this control. This prolongation of S phase is tightly integrated with a developmental program of chromatin changes that introduces epigenetic controls. Using GFP tagged proteins marking molecular hallmarks of these events, we are able to watch them occur in real time in embryos and to probe the processes that regulate their onset.

      A newer effort explores the genetics and biology of the mitochondria. Our principle interest is in a newly recognized mystery. The mitochondrial genome encodes functions that benefit the host rather than propagation and transmission of the mitochondrial genome. This would not be problem if evolution of this genome were based on the usual selection for fit organisms as Darwin suggests. However, we found that selection is based on the ability of genomes to compete for transmission from one generation to the next. This ought to select for selfish genes promoting genome success. To achieve the real outcome, the host manipulates the competition to favor genes to its benefit. We are trying to understand how this managed evolution is achieved.

      Collapse ORNG Applications 
      Collapse NIH Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. O'Farrell PH. Growing an Embryo from a Single Cell: A Hurdle in Animal Life. Cold Spring Harb Perspect Biol. 2015; 7(11).
        View in: PubMed
      2. Ma H, O'Farrell PH. Selections that isolate recombinant mitochondrial genomes in animals. Elife. 2015; 4.
        View in: PubMed
      3. Yuan K, O'Farrell PH. Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition. Curr Biol. 2015 Mar 16; 25(6):811-6.
        View in: PubMed
      4. Farrell JA, O'Farrell PH. From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014 Nov 23; 48:269-94.
        View in: PubMed
      5. Ma H, Xu H, O'Farrell PH. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7.
        View in: PubMed PMC4091738
      6. O'Farrell PH. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3.
        View in: PubMed
      7. Yuan K, Shermoen AW, O'Farrell PH. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5.
        View in: PubMed PMC3977024
      8. Farrell JA, O'Farrell PH. Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
        View in: PubMed PMC4091758
      9. Yuan K, Farrell JA, O'Farrell PH. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
        View in: PubMed PMC3444785
      10. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 1; 26(7):714-25.
        View in: PubMed PMC3323882
      11. DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
        View in: PubMed PMC3306594
      12. O'Farrell PH. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
        View in: PubMed PMC3203459
      13. Shermoen AW, McCleland ML, O'Farrell PH. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 7; 20(23):2067-77.
        View in: PubMed PMC3108027
      14. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
        View in: PubMed PMC2861863
      15. O'Farrell PH. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
        View in: PubMed PMC2869091
      16. McCleland ML, Shermoen AW, O'Farrell PH. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 5; 187(1):7-14.
        View in: PubMed PMC2762091
      17. Dijkers PF, O'Farrell PH. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
        View in: PubMed PMC2743626
      18. McCleland ML, Farrell JA, O'Farrell PH. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 9; 184(5):639-46.
        View in: PubMed PMC2686416
      19. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
        View in: PubMed
      20. O'Farrell PH. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
        View in: PubMed PMC2731566
      21. Xu H, DeLuca SZ, O'Farrell PH. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
        View in: PubMed PMC2754248
      22. Lee SJ, Feldman R, O'Farrell PH. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
        View in: PubMed PMC2555944
      23. Hickson GR, O'Farrell PH. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41.
        View in: PubMed PMC2695931
      24. McCleland ML, O'Farrell PH. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54.
        View in: PubMed PMC2698964
      25. Hickson GR, O'Farrell PH. Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28; 180(2):285-94.
        View in: PubMed PMC2213597
      26. Dijkers PF, O'Farrell PH. Drosophila calcineurin promotes induction of innate immune responses. Curr Biol. 2007 Dec 4; 17(23):2087-93.
        View in: PubMed PMC2180389
      27. Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, Andino R. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006 Aug; 8(8):793-802.
        View in: PubMed PMC2731564
      28. Hickson GR, Echard A, O'Farrell PH. Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006 Feb 21; 16(4):359-70.
        View in: PubMed PMC1525334
      29. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006 Jan; 4(1):e4.
        View in: PubMed PMC1310651
      30. Echard A, Hickson GR, Foley E, O'Farrell PH. Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol. 2004 Sep 21; 14(18):1685-93.
        View in: PubMed PMC2899696
      31. Foley E, O'Farrell PH. Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol. 2004 Aug; 2(8):E203.
        View in: PubMed PMC434151
      32. O'Farrell PH, Stumpff J, Su TT. Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol. 2004 Jan 6; 14(1):R35-45.
        View in: PubMed PMC2712630
      33. Hériché JK, Ang D, Bier E, O'Farrell PH. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 4; 4:9.
        View in: PubMed PMC161817
      34. Parry DH, Hickson GR, O'Farrell PH. Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol. 2003 Apr 15; 13(8):647-53.
        View in: PubMed PMC2749715
      35. Echard A, O'Farrell PH. The degradation of two mitotic cyclins contributes to the timing of cytokinesis. Curr Biol. 2003 Mar 4; 13(5):373-83.
        View in: PubMed PMC2754242
      36. Teodoro RO, O'Farrell PH. Nitric oxide-induced suspended animation promotes survival during hypoxia. EMBO J. 2003 Feb 3; 22(3):580-7.
        View in: PubMed PMC140754
      37. Vidwans SJ, Wong ML, O'Farrell PH. Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation. J Cell Sci. 2003 Jan 1; 116(Pt 1):137-43.
        View in: PubMed PMC2754245
      38. Foley E, O'Farrell PH. Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev. 2003 Jan 1; 17(1):115-25.
        View in: PubMed PMC195964
      39. Vidwans SJ, DiGregorio PJ, Shermoen AW, Foat B, Iwasa J, Yakubovich N, O'Farrell PH. Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Curr Biol. 2002 May 14; 12(10):829-33.
        View in: PubMed PMC2754250
      40. O'Farrell PH. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 2001 Dec; 11(12):512-9.
        View in: PubMed PMC2765372
      41. Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell PH, Purdy A. Cell cycle roles for two 14-3-3 proteins during Drosophila development. J Cell Sci. 2001 Oct; 114(Pt 19):3445-54.
        View in: PubMed PMC2754241
      42. Parry DH, O'Farrell PH. The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001 May 1; 11(9):671-83.
        View in: PubMed PMC2875931
      43. O'Farrell PH. Conserved responses to oxygen deprivation. J Clin Invest. 2001 Mar; 107(6):671-4.
        View in: PubMed PMC208955
      44. DiGregorio PJ, Ubersax JA, O'Farrell PH. Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions. J Biol Chem. 2001 Jan 19; 276(3):1930-7.
        View in: PubMed PMC2754243
      45. Price D, Rabinovitch S, O'Farrell PH, Campbell SD. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Genetics. 2000 May; 155(1):159-66.
        View in: PubMed PMC1461082
      46. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S. Comparative genomics of the eukaryotes. Science. 2000 Mar 24; 287(5461):2204-15.
        View in: PubMed PMC2754258
      47. Vidwans SJ, Wong ML, O'Farrell PH. Mitotic regulators govern progress through steps in the centrosome duplication cycle. J Cell Biol. 1999 Dec 27; 147(7):1371-8.
        View in: PubMed PMC2174235
      48. Foley E, O'Farrell PH, Sprenger F. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol. 1999 Dec 2; 9(23):1392-402.
        View in: PubMed PMC2754244
      49. Wilkie GS, Shermoen AW, O'Farrell PH, Davis I. Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei. Curr Biol. 1999 Nov 4; 9(21):1263-6.
        View in: PubMed PMC2754251
      50. Vidwans SJ, O'Farrell PH. Cytoskeleton: centrosom-in absentia. Curr Biol. 1999 Oct 21; 9(20):R764-6.
        View in: PubMed PMC2754240
      51. Su TT, Campbell SD, O'Farrell PH. Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events. Curr Biol. 1999 Aug 26; 9(16):919-22.
        View in: PubMed PMC2749710
      52. Wingrove JA, O'Farrell PH. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Cell. 1999 Jul 9; 98(1):105-14.
        View in: PubMed PMC2754235
      53. Su TT, O'Farrell PH. Size control: cell proliferation does not equal growth. Curr Biol. 1998 Sep 24; 8(19):R687-9.
        View in: PubMed PMC2754256
      54. Su TT, Sprenger F, DiGregorio PJ, Campbell SD, O'Farrell PH. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 1998 May 15; 12(10):1495-503.
        View in: PubMed PMC316833
      55. Su TT, Campbell SD, O'Farrell PH. The cell cycle program in germ cells of the Drosophila embryo. Dev Biol. 1998 Apr 15; 196(2):160-70.
        View in: PubMed
      56. Follette PJ, Duronio RJ, O'Farrell PH. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998 Feb 12; 8(4):235-8.
        View in: PubMed PMC2754236
      57. Su TT, O'Farrell PH. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J Cell Biol. 1998 Feb 9; 140(3):451-60.
        View in: PubMed PMC2140170
      58. Duronio RJ, Bonnette PC, O'Farrell PH. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998 Jan; 18(1):141-51.
        View in: PubMed PMC121467
      59. Su TT, O'Farrell PH. Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J Cell Biol. 1997 Oct 6; 139(1):13-21.
        View in: PubMed PMC2139827
      60. Sprenger F, Yakubovich N, O'Farrell PH. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol. 1997 Jul 1; 7(7):488-99.
        View in: PubMed PMC2754254
      61. Su TT, Yakubovich N, O'Farrell PH. Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. Gene. 1997 Jun 19; 192(2):283-9.
        View in: PubMed PMC2753454
      62. Serrano N, O'Farrell PH. Limb morphogenesis: connections between patterning and growth. Curr Biol. 1997 Mar 1; 7(3):R186-95.
        View in: PubMed PMC2749718
      63. Follette PJ, O'Farrell PH. Connecting cell behavior to patterning: lessons from the cell cycle. Cell. 1997 Feb 7; 88(3):309-14.
        View in: PubMed PMC2754257
      64. Follette PJ, O'Farrell PH. Cdks and the Drosophila cell cycle. Curr Opin Genet Dev. 1997 Feb; 7(1):17-22.
        View in: PubMed PMC2753438
      65. Duronio RJ, Brook A, Dyson N, O'Farrell PH. E2F-induced S phase requires cyclin E. Genes Dev. 1996 Oct 1; 10(19):2505-13.
        View in: PubMed
      66. Leclerc V, Tassan JP, O'Farrell PH, Nigg EA, Léopold P. Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. Mol Biol Cell. 1996 Apr; 7(4):505-13.
        View in: PubMed PMC275905
      67. Su TT, Feger G, O'Farrell PH. Drosophila MCM protein complexes. Mol Biol Cell. 1996 Feb; 7(2):319-29.
        View in: PubMed PMC275882
      68. O'Farrell P. Hydrophobic interaction chromatography. Methods Mol Biol. 1996; 59:151-5.
        View in: PubMed
      69. Campbell SD, Sprenger F, Edgar BA, O'Farrell PH. Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol Biol Cell. 1995 Oct; 6(10):1333-47.
        View in: PubMed PMC301291
      70. Davis I, Girdham CH, O'Farrell PH. A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev Biol. 1995 Aug; 170(2):726-9.
        View in: PubMed
      71. Treisman JE, Follette PJ, O'Farrell PH, Rubin GM. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 1995 Jul 15; 9(14):1709-15.
        View in: PubMed
      72. Su TT, Follette PJ, O'Farrell PH. Qualifying for the license to replicate. Cell. 1995 Jun 16; 81(6):825-8.
        View in: PubMed PMC2755094
      73. Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995 Jun 15; 9(12):1445-55.
        View in: PubMed
      74. Duronio RJ, O'Farrell PH. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995 Jun 15; 9(12):1456-68.
        View in: PubMed
      75. Edgar BA, Lehman DA, O'Farrell PH. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development. 1994 Nov; 120(11):3131-43.
        View in: PubMed PMC2753456
      76. DiNardo S, Heemskerk J, Dougan S, O'Farrell PH. The making of a maggot: patterning the Drosophila embryonic epidermis. Curr Opin Genet Dev. 1994 Aug; 4(4):529-34.
        View in: PubMed PMC2873142
      77. Vincent JP, Girdham CH, O'Farrell PH. A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev Biol. 1994 Jul; 164(1):328-31.
        View in: PubMed
      78. Duronio RJ, O'Farrell PH. Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994 Jun; 120(6):1503-15.
        View in: PubMed PMC2753441
      79. O'Farrell PH. Developmental biology. Unanimity waits in the wings. Nature. 1994 Mar 17; 368(6468):188-9.
        View in: PubMed PMC2763625
      80. Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell PH. Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev. 1994 Feb 15; 8(4):440-52.
        View in: PubMed
      81. Girdham CH, O'Farrell PH. The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis. Methods Cell Biol. 1994; 44:533-43.
        View in: PubMed
      82. Kalionis B, O'Farrell PH. A universal target sequence is bound in vitro by diverse homeodomains. Mech Dev. 1993 Sep; 43(1):57-70.
        View in: PubMed PMC2755072
      83. Moazed D, O'Farrell PH. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10.
        View in: PubMed PMC2755082
      84. O'Farrell PH. Developmental biology. Big genes and little genes and deadlines for transcription. Nature. 1992 Oct 1; 359(6394):366-7.
        View in: PubMed PMC2754300
      85. O'Farrell PH. Cell cycle control: many ways to skin a cat. Trends Cell Biol. 1992 Jun; 2(6):159-63.
        View in: PubMed
      86. Vincent JP, O'Farrell PH. The state of engrailed expression is not clonally transmitted during early Drosophila development. Cell. 1992 Mar 6; 68(5):923-31.
        View in: PubMed PMC2753444
      87. Shermoen AW, O'Farrell PH. Progression of the cell cycle through mitosis leads to abortion of nascent transcripts. Cell. 1991 Oct 18; 67(2):303-10.
        View in: PubMed PMC2755073
      88. Léopold P, O'Farrell PH. An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell. 1991 Sep 20; 66(6):1207-16.
        View in: PubMed PMC2753436
      89. Heemskerk J, DiNardo S, Kostriken R, O'Farrell PH. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature. 1991 Aug 1; 352(6334):404-10.
        View in: PubMed PMC2755087
      90. Jaynes JB, O'Farrell PH. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 1991 Jun; 10(6):1427-33.
        View in: PubMed PMC452804
      91. Lehner CF, Yakubovich N, O'Farrell PH. Exploring the role of Drosophila cyclin A in the regulation of S phase. Cold Spring Harb Symp Quant Biol. 1991; 56:465-75.
        View in: PubMed
      92. O'Farrell P, Léopold P. A consensus of cyclin sequences reveals homology with the ras oncogene. Cold Spring Harb Symp Quant Biol. 1991; 56:83-92.
        View in: PubMed
      93. Lehner CF, O'Farrell PH. Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 1990 Nov; 9(11):3573-81.
        View in: PubMed PMC552108
      94. Edgar BA, O'Farrell PH. The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell. 1990 Aug 10; 62(3):469-80.
        View in: PubMed PMC2753418
      95. Vincent JP, Kassis JA, O'Farrell PH. A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J. 1990 Aug; 9(8):2573-8.
        View in: PubMed PMC552289
      96. Lehner CF, O'Farrell PH. The roles of Drosophila cyclins A and B in mitotic control. Cell. 1990 May 4; 61(3):535-47.
        View in: PubMed PMC2753431
      97. O'Farrell PH, Edgar BA, Lakich D, Lehner CF. Directing cell division during development. Science. 1989 Nov 3; 246(4930):635-40.
        View in: PubMed
      98. Kassis JA, Desplan C, Wright DK, O'Farrell PH. Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol. 1989 Oct; 9(10):4304-11.
        View in: PubMed PMC362511
      99. Edgar BA, O'Farrell PH. Genetic control of cell division patterns in the Drosophila embryo. Cell. 1989 Apr 7; 57(1):177-87.
        View in: PubMed PMC2755076
      100. Lehner CF, O'Farrell PH. Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell. 1989 Mar 24; 56(6):957-68.
        View in: PubMed PMC2753420
      101. Jaynes JB, O'Farrell PH. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature. 1988 Dec 22-29; 336(6201):744-9.
        View in: PubMed PMC2868829
      102. Desplan C, Theis J, O'Farrell PH. The sequence specificity of homeodomain-DNA interaction. Cell. 1988 Sep 23; 54(7):1081-90.
        View in: PubMed PMC2753412
      103. DiNardo S, Sher E, Heemskerk-Jongens J, Kassis JA, O'Farrell PH. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature. 1988 Apr 14; 332(6165):604-9.
        View in: PubMed PMC2753417
      104. Carroll SB, DiNardo S, O'Farrell PH, White RA, Scott MP. Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. Genes Dev. 1988 Mar; 2(3):350-60.
        View in: PubMed
      105. DiNardo S, O'Farrell PH. Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1987 Dec; 1(10):1212-25.
        View in: PubMed
      106. Kassis JA, Poole SJ, Wright DK, O'Farrell PH. Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J. 1986 Dec 20; 5(13):3583-9.
        View in: PubMed PMC1167397
      107. Scott MP, O'Farrell PH. Spatial programming of gene expression in early Drosophila embryogenesis. Annu Rev Cell Biol. 1986; 2:49-80.
        View in: PubMed
      108. Desplan C, Theis J, O'Farrell PH. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985 Dec 19-1986 Jan 1; 318(6047):630-5.
        View in: PubMed PMC2880619
      109. Kassis JA, Wong ML, O'Farrell PH. Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis. Mol Cell Biol. 1985 Dec; 5(12):3600-9.
        View in: PubMed PMC369191
      110. DiNardo S, Kuner JM, Theis J, O'Farrell PH. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell. 1985 Nov; 43(1):59-69.
        View in: PubMed PMC2879874
      111. Kuner JM, Nakanishi M, Ali Z, Drees B, Gustavson E, Theis J, Kauvar L, Kornberg T, O'Farrell PH. Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell. 1985 Aug; 42(1):309-16.
        View in: PubMed PMC2753415
      112. O'Farrell PH, Desplan C, DiNardo S, Kassis JA, Kuner JM, Sher E, Theis J, Wright D. Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein. Cold Spring Harb Symp Quant Biol. 1985; 50:235-42.
        View in: PubMed
      113. Kornberg T, Sidén I, O'Farrell P, Simon M. The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression. Cell. 1985 Jan; 40(1):45-53.
        View in: PubMed
      114. Ivarie RD, Schacter BS, O'Farrell PH. The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells. Mol Cell Biol. 1983 Aug; 3(8):1460-7.
        View in: PubMed PMC369992
      115. Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN. Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:233-45.
        View in: PubMed
      116. O'Farrell PH, Ivarie RD. The glucocorticoid domain of response: measurement of pleiotropic cellular responses by two-dimensional gel electrophoresis. Monogr Endocrinol. 1979; 12:189-201.
        View in: PubMed
      117. Gelfand DH, Shepard HM, O'Farrell PH, Polisky B. Isolation and characterization of ColE1-derived plasmid copy-number mutant. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5869-73.
        View in: PubMed PMC393077
      118. O'Farrell PH. The suppression of defective translation by ppGpp and its role in the stringent response. Cell. 1978 Jul; 14(3):545-57.
        View in: PubMed
      119. O'Farrell P, Polisky B, Gelfand DH. Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase. J Bacteriol. 1978 May; 134(2):645-54.
        View in: PubMed PMC222298
      120. Ivarie RD, O'Farrell PH. The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins. Cell. 1978 Jan; 13(1):41-55.
        View in: PubMed
      121. O'Farrell PZ, Goodman HM, O'Farrell PH. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 1977 Dec; 12(4):1133-41.
        View in: PubMed
      122. Steinberg RA, O'Farrell PH, Friedrich U, Coffino P. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Cell. 1977 Mar; 10(3):381-91.
        View in: PubMed
      123. O'Farrell PH, O'Farrell PZ. Two-dimensional polyacrylamide gel electrophoretic fractionation. Methods Cell Biol. 1977; 16:407-20.
        View in: PubMed
      124. O'Farrell PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 1975 May 25; 250(10):4007-21.
        View in: PubMed PMC2874754
      Patrick's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP