Patrick O'Farrell, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #S372C
San Francisco CA 94158
ORCID ORCID Icon0000-0003-0011-2734 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Jane Coffin Childs Fund for Medical Research1975  - 1979Postdoctoral Fellowship
    California Division of the American Cancer Society1978  - 1979Senior Postdoctoral Fellow
    Sarstedt1989Research Prize for development of Electrophoretic Separations
    Postdoc. Scholars Assoc. UCSF2006Outstanding Mentorship Award
    American Academy of Arts and Sciences2009Elected Member
    Univ. of Lethbridge2012Honorary Doctorate
    Japanese Electrophoresis Society2014Research Prize
    National Academy of Sciences2017Elected Member

    Collapse Overview 
    Collapse Overview
    We are interested in the decoding of biological information to produce functional structures at the level of cells and organisms. We focus on the control of the cell cycle during development using Drosophila genetics, molecular biology and fancy microscopy. We are examining temporal coordination of early embryonic cell cycles with development. Having found that slowing early rapid cell cycles is due to prolongation of S phase, the period of DNA replication, we are studying this control. This prolongation of S phase is tightly integrated with a developmental program of chromatin changes that introduces epigenetic controls. Using GFP tagged proteins marking molecular hallmarks of these events, we are able to watch them occur in real time in embryos and to probe the processes that regulate their onset.

    A newer effort explores the genetics and biology of the mitochondria. Our principle interest is in a newly recognized mystery. The mitochondrial genome encodes functions that benefit the host rather than propagation and transmission of the mitochondrial genome. This would not be problem if evolution of this genome were based on the usual selection for fit organisms as Darwin suggests. However, we found that selection is based on the ability of genomes to compete for transmission from one generation to the next. This ought to select for selfish genes promoting genome success. To achieve the real outcome, the host manipulates the competition to favor genes to its benefit. We are trying to understand how this managed evolution is achieved.

    Collapse Research 
    Collapse Research Activities and Funding
    Embryonic Emergence of Heterochromatin and Nuclear Supervision of Mitochondrial Genetics
    NIH R35GM136324Jun 1, 2020 - May 31, 2025
    Role: Principal Investigator
    Host management of the mitochondrial genome
    NIH R01GM120005Sep 19, 2011 - Jun 30, 2020
    Role: Principal Investigator
    The genetic basis for tissue specific sensitivities to mitochondrial stress
    NIH R01ES020725Sep 19, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    NIH R01GM086854Mar 1, 2000 - Jul 31, 2013
    Role: Principal Investigator
    Nitric Oxide and Responses to Hypoxia in Drosophila
    NIH R01AI060102Mar 1, 2000 - Sep 29, 2008
    Role: Principal Investigator
    NIH R01GM060988Mar 1, 2000 - Apr 14, 2004
    Role: Principal Investigator
    Developmental Programs of Cell Cycle Control
    NIH R37GM037193Jul 1, 1986 - Jun 30, 2020
    Role: Principal Investigator
    Developmental Programs of Cell Cycle Control
    NIH R01GM037193Jul 1, 1986 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Coordinating transcription and replication to mitigate their conflicts in early Drosophila embryos. Cell Rep. 2022 10 18; 41(3):111507. Cho CY, Kemp JP, Duronio RJ, O'Farrell PH. PMID: 36261005; PMCID: PMC9667882.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    2. Mitigation of age-dependent accumulation of defective mitochondrial genomes. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2119009119. Tsai PI, Korotkevich E, O'Farrell PH. PMID: 35881807; PMCID: PMC9351377.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    3. Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila. Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2200780119. Cho CY, Seller CA, O'Farrell PH. PMID: 35733247; PMCID: PMC9245680.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    4. Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio. PLoS Biol. 2020 10; 18(10):e3000891. Strong IJT, Lei X, Chen F, Yuan K, O'Farrell PH. PMID: 33090988; PMCID: PMC7608951.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    5. A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations. Curr Biol. 2019 12 16; 29(24):4330-4336.e3. Chiang AC, McCartney E, O'Farrell PH, Ma H. PMID: 31786061; PMCID: PMC6926476.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila. Genes Dev. 2019 04 01; 33(7-8):403-417. Seller CA, Cho CY, O'Farrell PH. PMID: 30808658; PMCID: PMC6446540.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    7. Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 2018 05; 16(5):e2005687. Seller CA, O'Farrell PH. PMID: 29746464; PMCID: PMC5963817.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    8. Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research. Dis Model Mech. 2017 12 19; 10(12):1381-1389. Duronio RJ, O'Farrell PH, Sluder G, Su TT. PMID: 29259023; PMCID: PMC5769611.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    9. The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes. Curr Biol. 2017 Apr 03; 27(7):1033-1039. Yu Z, O'Farrell PH, Yakubovich N, DeLuca SZ. PMID: 28318978; PMCID: PMC5391691.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    10. Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View. Trends Genet. 2016 08; 32(8):496-507. Yuan K, Seller CA, Shermoen AW, O'Farrell PH. PMID: 27339317; PMCID: PMC4958567.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    11. Selfish drive can trump function when animal mitochondrial genomes compete. Nat Genet. 2016 07; 48(7):798-802. Ma H, O'Farrell PH. PMID: 27270106; PMCID: PMC4925267.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    12. TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos. Genes Dev. 2016 Mar 01; 30(5):579-93. Yuan K, O'Farrell PH. PMID: 26915820; PMCID: PMC4782051.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    13. Growing an Embryo from a Single Cell: A Hurdle in Animal Life. Cold Spring Harb Perspect Biol. 2015 Aug 07; 7(11). O'Farrell PH. PMID: 26254311; PMCID: PMC4632664.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    14. Selections that isolate recombinant mitochondrial genomes in animals. Elife. 2015 Aug 03; 4. Ma H, O'Farrell PH. PMID: 26237110; PMCID: PMC4584245.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    15. Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol. 2015 Mar 16; 25(6):811-816. Yuan K, O'Farrell PH. PMID: 25754637; PMCID: PMC4412444.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    16. From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014; 48:269-94. Farrell JA, O'Farrell PH. PMID: 25195504; PMCID: PMC4484755.
      View in: PubMed   Mentions: 98     Fields:    Translation:Animals
    17. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7. Ma H, Xu H, O'Farrell PH. PMID: 24614071; PMCID: PMC4091738.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    18. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3. O'Farrell PH. PMID: 24568796.
      View in: PubMed   Mentions:    Fields:    
    19. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5. Yuan K, Shermoen AW, O'Farrell PH. PMID: 24556431; PMCID: PMC3977024.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26. Farrell JA, O'Farrell PH. PMID: 23290551; PMCID: PMC4091758.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    21. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80. Yuan K, Farrell JA, O'Farrell PH. PMID: 22965907; PMCID: PMC3444785.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 01; 26(7):714-25. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. PMID: 22431511; PMCID: PMC3323882.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    23. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8. DeLuca SZ, O'Farrell PH. PMID: 22421049; PMCID: PMC3306594.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    24. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507. O'Farrell PH. PMID: 22084377; PMCID: PMC3203459.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    25. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 07; 20(23):2067-77. Shermoen AW, McCleland ML, O'Farrell PH. PMID: 21074439; PMCID: PMC3108027.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    26. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2. Yakubovich N, Silva EA, O'Farrell PH. PMID: 20178753; PMCID: PMC2861863.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    27. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4. O'Farrell PH. PMID: 20213891; PMCID: PMC2869091.
      View in: PubMed   Mentions:    Fields:    
    28. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 05; 187(1):7-14. McCleland ML, Shermoen AW, O'Farrell PH. PMID: 19786576; PMCID: PMC2762091.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    29. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90. Dijkers PF, O'Farrell PH. PMID: 19625446; PMCID: PMC2743626.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 09; 184(5):639-46. McCleland ML, Farrell JA, O'Farrell PH. PMID: 19273612; PMCID: PMC2686416.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. PMID: 19089394.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52. O'Farrell PH. PMID: 19003855; PMCID: PMC2731566.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7. Xu H, DeLuca SZ, O'Farrell PH. PMID: 18653897; PMCID: PMC2754248.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    34. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61. Lee SJ, Feldman R, O'Farrell PH. PMID: 18653470; PMCID: PMC2555944.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41. Hickson GR, O'Farrell PH. PMID: 18481976; PMCID: PMC2695931.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    36. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54. McCleland ML, O'Farrell PH. PMID: 18291653; PMCID: PMC2698964.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    37. Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28; 180(2):285-94. Hickson GR, O'Farrell PH. PMID: 18209105; PMCID: PMC2213597.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    38. Drosophila calcineurin promotes induction of innate immune responses. Curr Biol. 2007 Dec 04; 17(23):2087-93. Dijkers PF, O'Farrell PH. PMID: 18060786; PMCID: PMC2180389.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006 Aug; 8(8):793-802. Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, Andino R. PMID: 16862146; PMCID: PMC2731564.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    40. Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006 Feb 21; 16(4):359-70. Hickson GR, Echard A, O'Farrell PH. PMID: 16488869; PMCID: PMC1525334.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    41. Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006 Jan; 4(1):e4. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. PMID: 16336044; PMCID: PMC1310651.
      View in: PubMed   Mentions: 120     Fields:    Translation:Animals
    42. Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol. 2004 Sep 21; 14(18):1685-93. Echard A, Hickson GR, Foley E, O'Farrell PH. PMID: 15380073; PMCID: PMC2899696.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    43. Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol. 2004 Aug; 2(8):E203. Foley E, O'Farrell PH. PMID: 15221030; PMCID: PMC434151.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    44. Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol. 2004 Jan 06; 14(1):R35-45. O'Farrell PH, Stumpff J, Su TT. PMID: 14711435; PMCID: PMC2712630.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    45. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 04; 4:9. Hériché JK, Ang D, Bier E, O'Farrell PH. PMID: 12787468; PMCID: PMC161817.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    46. Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol. 2003 Apr 15; 13(8):647-53. Parry DH, Hickson GR, O'Farrell PH. PMID: 12699620; PMCID: PMC2749715.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    47. The degradation of two mitotic cyclins contributes to the timing of cytokinesis. Curr Biol. 2003 Mar 04; 13(5):373-83. Echard A, O'Farrell PH. PMID: 12620185; PMCID: PMC2754242.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    48. Nitric oxide-induced suspended animation promotes survival during hypoxia. EMBO J. 2003 Feb 03; 22(3):580-7. Teodoro RO, O'Farrell PH. PMID: 12554658; PMCID: PMC140754.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    49. Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation. J Cell Sci. 2003 Jan 01; 116(Pt 1):137-43. Vidwans SJ, Wong ML, O'Farrell PH. PMID: 12456723; PMCID: PMC2754245.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    50. Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev. 2003 Jan 01; 17(1):115-25. Foley E, O'Farrell PH. PMID: 12514104; PMCID: PMC195964.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    51. Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Curr Biol. 2002 May 14; 12(10):829-33. Vidwans SJ, DiGregorio PJ, Shermoen AW, Foat B, Iwasa J, Yakubovich N, O'Farrell PH. PMID: 12015119; PMCID: PMC2754250.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    52. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 2001 Dec; 11(12):512-9. O'Farrell PH. PMID: 11719058; PMCID: PMC2765372.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    53. Cell cycle roles for two 14-3-3 proteins during Drosophila development. J Cell Sci. 2001 Oct; 114(Pt 19):3445-54. Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell PH, Purdy A. PMID: 11682604; PMCID: PMC2754241.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    54. The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001 May 01; 11(9):671-83. Parry DH, O'Farrell PH. PMID: 11369230; PMCID: PMC2875931.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    55. Conserved responses to oxygen deprivation. J Clin Invest. 2001 Mar; 107(6):671-4. O'Farrell PH. PMID: 11254666; PMCID: PMC208955.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    56. Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions. J Biol Chem. 2001 Jan 19; 276(3):1930-7. DiGregorio PJ, Ubersax JA, O'Farrell PH. PMID: 11054409; PMCID: PMC2754243.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    57. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Genetics. 2000 May; 155(1):159-66. Price D, Rabinovitch S, O'Farrell PH, Campbell SD. PMID: 10790391; PMCID: PMC1461082.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    58. Comparative genomics of the eukaryotes. Science. 2000 Mar 24; 287(5461):2204-15. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S. PMID: 10731134; PMCID: PMC2754258.
      View in: PubMed   Mentions: 492     Fields:    Translation:HumansAnimalsCells
    59. Mitotic regulators govern progress through steps in the centrosome duplication cycle. J Cell Biol. 1999 Dec 27; 147(7):1371-8. Vidwans SJ, Wong ML, O'Farrell PH. PMID: 10613895; PMCID: PMC2174235.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    60. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol. 1999 Dec 02; 9(23):1392-402. Foley E, O'Farrell PH, Sprenger F. PMID: 10607563; PMCID: PMC2754244.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    61. Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei. Curr Biol. 1999 Nov 04; 9(21):1263-6. Wilkie GS, Shermoen AW, O'Farrell PH, Davis I. PMID: 10556096; PMCID: PMC2754251.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    62. Cytoskeleton: centrosom-in absentia. Curr Biol. 1999 Oct 21; 9(20):R764-6. Vidwans SJ, O'Farrell PH. PMID: 10531022; PMCID: PMC2754240.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    63. Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events. Curr Biol. 1999 Aug 26; 9(16):919-22. Su TT, Campbell SD, O'Farrell PH. PMID: 10469601; PMCID: PMC2749710.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    64. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Cell. 1999 Jul 09; 98(1):105-14. Wingrove JA, O'Farrell PH. PMID: 10412985; PMCID: PMC2754235.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    65. Size control: cell proliferation does not equal growth. Curr Biol. 1998 Sep 24; 8(19):R687-9. Su TT, O'Farrell PH. PMID: 9768354; PMCID: PMC2754256.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    66. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 1998 May 15; 12(10):1495-503. Su TT, Sprenger F, DiGregorio PJ, Campbell SD, O'Farrell PH. PMID: 9585509; PMCID: PMC316833.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    67. The cell cycle program in germ cells of the Drosophila embryo. Dev Biol. 1998 Apr 15; 196(2):160-70. Su TT, Campbell SD, O'Farrell PH. PMID: 9576829.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    68. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998 Feb 12; 8(4):235-8. Follette PJ, Duronio RJ, O'Farrell PH. PMID: 9501987; PMCID: PMC2754236.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    69. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J Cell Biol. 1998 Feb 09; 140(3):451-60. Su TT, O'Farrell PH. PMID: 9456309; PMCID: PMC2140170.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    70. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998 Jan; 18(1):141-51. Duronio RJ, Bonnette PC, O'Farrell PH. PMID: 9418862; PMCID: PMC121467.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    71. Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J Cell Biol. 1997 Oct 06; 139(1):13-21. Su TT, O'Farrell PH. PMID: 9314525; PMCID: PMC2139827.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    72. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol. 1997 Jul 01; 7(7):488-99. Sprenger F, Yakubovich N, O'Farrell PH. PMID: 9210381; PMCID: PMC2754254.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    73. Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. Gene. 1997 Jun 19; 192(2):283-9. Su TT, Yakubovich N, O'Farrell PH. PMID: 9224901; PMCID: PMC2753454.
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    74. Limb morphogenesis: connections between patterning and growth. Curr Biol. 1997 Mar 01; 7(3):R186-95. Serrano N, O'Farrell PH. PMID: 9162486; PMCID: PMC2749718.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    75. Connecting cell behavior to patterning: lessons from the cell cycle. Cell. 1997 Feb 07; 88(3):309-14. Follette PJ, O'Farrell PH. PMID: 9039257; PMCID: PMC2754257.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    76. Cdks and the Drosophila cell cycle. Curr Opin Genet Dev. 1997 Feb; 7(1):17-22. Follette PJ, O'Farrell PH. PMID: 9024630; PMCID: PMC2753438.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    77. E2F-induced S phase requires cyclin E. Genes Dev. 1996 Oct 01; 10(19):2505-13. Duronio RJ, Brook A, Dyson N, O'Farrell PH. PMID: 8843201.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    78. Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. Mol Biol Cell. 1996 Apr; 7(4):505-13. Leclerc V, Tassan JP, O'Farrell PH, Nigg EA, Léopold P. PMID: 8730095; PMCID: PMC275905.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    79. Drosophila MCM protein complexes. Mol Biol Cell. 1996 Feb; 7(2):319-29. Su TT, Feger G, O'Farrell PH. PMID: 8688561; PMCID: PMC275882.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    80. Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol Biol Cell. 1995 Oct; 6(10):1333-47. Campbell SD, Sprenger F, Edgar BA, O'Farrell PH. PMID: 8573790; PMCID: PMC301291.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    81. A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev Biol. 1995 Aug; 170(2):726-9. Davis I, Girdham CH, O'Farrell PH. PMID: 7649398.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    82. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 1995 Jul 15; 9(14):1709-15. Treisman JE, Follette PJ, O'Farrell PH, Rubin GM. PMID: 7622035.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    83. Qualifying for the license to replicate. Cell. 1995 Jun 16; 81(6):825-8. Su TT, Follette PJ, O'Farrell PH. PMID: 7781058; PMCID: PMC2755094.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    84. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995 Jun 15; 9(12):1445-55. Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. PMID: 7601349.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    85. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995 Jun 15; 9(12):1456-68. Duronio RJ, O'Farrell PH. PMID: 7601350.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    86. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development. 1994 Nov; 120(11):3131-43. Edgar BA, Lehman DA, O'Farrell PH. PMID: 7720557; PMCID: PMC2753456.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    87. The making of a maggot: patterning the Drosophila embryonic epidermis. Curr Opin Genet Dev. 1994 Aug; 4(4):529-34. DiNardo S, Heemskerk J, Dougan S, O'Farrell PH. PMID: 7950320; PMCID: PMC2873142.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    88. A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev Biol. 1994 Jul; 164(1):328-31. Vincent JP, Girdham CH, O'Farrell PH. PMID: 8026635.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    89. Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994 Jun; 120(6):1503-15. Duronio RJ, O'Farrell PH. PMID: 8050359; PMCID: PMC2753441.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    90. Developmental biology. Unanimity waits in the wings. Nature. 1994 Mar 17; 368(6468):188-9. O'Farrell PH. PMID: 8145815; PMCID: PMC2763625.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    91. Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev. 1994 Feb 15; 8(4):440-52. Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell PH. PMID: 7510257; PMCID: PMC6520052.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    92. The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis. Methods Cell Biol. 1994; 44:533-43. Girdham CH, O'Farrell PH. PMID: 7535883.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    93. A universal target sequence is bound in vitro by diverse homeodomains. Mech Dev. 1993 Sep; 43(1):57-70. Kalionis B, O'Farrell PH. PMID: 7902124; PMCID: PMC2755072.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    94. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10. Moazed D, O'Farrell PH. PMID: 1363229; PMCID: PMC2755082.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    95. Developmental biology. Big genes and little genes and deadlines for transcription. Nature. 1992 Oct 01; 359(6394):366-7. O'Farrell PH. PMID: 1406945; PMCID: PMC2754300.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    96. Cell cycle control: many ways to skin a cat. Trends Cell Biol. 1992 Jun; 2(6):159-63. O'Farrell PH. PMID: 14731984.
      View in: PubMed   Mentions: 9     Fields:    
    97. The state of engrailed expression is not clonally transmitted during early Drosophila development. Cell. 1992 Mar 06; 68(5):923-31. Vincent JP, O'Farrell PH. PMID: 1547492; PMCID: PMC2753444.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    98. Progression of the cell cycle through mitosis leads to abortion of nascent transcripts. Cell. 1991 Oct 18; 67(2):303-10. Shermoen AW, O'Farrell PH. PMID: 1680567; PMCID: PMC2755073.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    99. An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell. 1991 Sep 20; 66(6):1207-16. Léopold P, O'Farrell PH. PMID: 1833067; PMCID: PMC2753436.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    100. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature. 1991 Aug 01; 352(6334):404-10. Heemskerk J, DiNardo S, Kostriken R, O'Farrell PH. PMID: 1861720; PMCID: PMC2755087.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    101. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 1991 Jun; 10(6):1427-33. Jaynes JB, O'Farrell PH. PMID: 1673924; PMCID: PMC452804.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    102. Exploring the role of Drosophila cyclin A in the regulation of S phase. Cold Spring Harb Symp Quant Biol. 1991; 56:465-75. Lehner CF, Yakubovich N, O'Farrell PH. PMID: 1840259.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    103. Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 1990 Nov; 9(11):3573-81. Lehner CF, O'Farrell PH. PMID: 2120045; PMCID: PMC552108.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    104. The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell. 1990 Aug 10; 62(3):469-80. Edgar BA, O'Farrell PH. PMID: 2199063; PMCID: PMC2753418.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    105. A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J. 1990 Aug; 9(8):2573-8. Vincent JP, Kassis JA, O'Farrell PH. PMID: 1973384; PMCID: PMC552289.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    106. The roles of Drosophila cyclins A and B in mitotic control. Cell. 1990 May 04; 61(3):535-47. Lehner CF, O'Farrell PH. PMID: 2139805; PMCID: PMC2753431.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    107. Directing cell division during development. Science. 1989 Nov 03; 246(4930):635-40. O'Farrell PH, Edgar BA, Lakich D, Lehner CF. PMID: 2683080.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    108. Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol. 1989 Oct; 9(10):4304-11. Kassis JA, Desplan C, Wright DK, O'Farrell PH. PMID: 2573829; PMCID: PMC362511.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    109. Genetic control of cell division patterns in the Drosophila embryo. Cell. 1989 Apr 07; 57(1):177-87. Edgar BA, O'Farrell PH. PMID: 2702688; PMCID: PMC2755076.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    110. Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell. 1989 Mar 24; 56(6):957-68. Lehner CF, O'Farrell PH. PMID: 2564316; PMCID: PMC2753420.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    111. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature. 1988 Dec 22-29; 336(6201):744-9. Jaynes JB, O'Farrell PH. PMID: 2905023; PMCID: PMC2868829.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    112. The sequence specificity of homeodomain-DNA interaction. Cell. 1988 Sep 23; 54(7):1081-90. Desplan C, Theis J, O'Farrell PH. PMID: 3046753; PMCID: PMC2753412.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    113. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature. 1988 Apr 14; 332(6165):604-9. DiNardo S, Sher E, Heemskerk-Jongens J, Kassis JA, O'Farrell PH. PMID: 3282172; PMCID: PMC2753417.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    114. Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. Genes Dev. 1988 Mar; 2(3):350-60. Carroll SB, DiNardo S, O'Farrell PH, White RA, Scott MP. PMID: 2897943.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    115. Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1987 Dec; 1(10):1212-25. DiNardo S, O'Farrell PH. PMID: 3123316.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    116. Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J. 1986 Dec 20; 5(13):3583-9. Kassis JA, Poole SJ, Wright DK, O'Farrell PH. PMID: 2881781; PMCID: PMC1167397.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    117. Spatial programming of gene expression in early Drosophila embryogenesis. Annu Rev Cell Biol. 1986; 2:49-80. Scott MP, O'Farrell PH. PMID: 2881561.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    118. Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis. Mol Cell Biol. 1985 Dec; 5(12):3600-9. Kassis JA, Wong ML, O'Farrell PH. PMID: 3939321; PMCID: PMC369191.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    119. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985 Dec 19-1986 Jan 1; 318(6047):630-5. Desplan C, Theis J, O'Farrell PH. PMID: 4079979; PMCID: PMC2880619.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    120. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell. 1985 Nov; 43(1):59-69. DiNardo S, Kuner JM, Theis J, O'Farrell PH. PMID: 3935318; PMCID: PMC2879874.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    121. Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell. 1985 Aug; 42(1):309-16. Kuner JM, Nakanishi M, Ali Z, Drees B, Gustavson E, Theis J, Kauvar L, Kornberg T, O'Farrell PH. PMID: 2990728; PMCID: PMC2753415.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    122. Separation techniques based on the opposition of two counteracting forces to produce a dynamic equilibrium. Science. 1985 Mar 29; 227(4694):1586-9. O'farrell PH. PMID: 17795350; PMCID: PMC2896869.
      View in: PubMed   Mentions: 2     Fields:    
    123. Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein. Cold Spring Harb Symp Quant Biol. 1985; 50:235-42. O'Farrell PH, Desplan C, DiNardo S, Kassis JA, Kuner JM, Sher E, Theis J, Wright D. PMID: 3006988.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    124. The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells. Mol Cell Biol. 1983 Aug; 3(8):1460-7. Ivarie RD, Schacter BS, O'Farrell PH. PMID: 6621533; PMCID: PMC369992.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    125. A restriction map of the bacteriophage T4 genome. Mol Gen Genet. 1980; 179(2):421-435. O'Farrell PH, Kutter E, Nakanishi M. PMID: 6258018; PMCID: PMC2868831.
      View in: PubMed   Mentions: 131     Fields:    Translation:Cells
    126. The glucocorticoid domain of response: measurement of pleiotropic cellular responses by two-dimensional gel electrophoresis. Monogr Endocrinol. 1979; 12:189-201. O'Farrell PH, Ivarie RD. PMID: 226869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    127. Isolation and characterization of ColE1-derived plasmid copy-number mutant. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5869-73. Gelfand DH, Shepard HM, O'Farrell PH, Polisky B. PMID: 104293; PMCID: PMC393077.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    128. The suppression of defective translation by ppGpp and its role in the stringent response. Cell. 1978 Jul; 14(3):545-57. O'Farrell PH. PMID: 357011.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    129. The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins. Cell. 1978 Jan; 13(1):41-55. Ivarie RD, O'Farrell PH. PMID: 23216.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    130. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 1977 Dec; 12(4):1133-41. O'Farrell PZ, Goodman HM, O'Farrell PH. PMID: 23215.
      View in: PubMed   Mentions: 862     Fields:    
    131. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Cell. 1977 Mar; 10(3):381-91. Steinberg RA, O'Farrell PH, Friedrich U, Coffino P. PMID: 191196.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    132. Two-dimensional polyacrylamide gel electrophoretic fractionation. Methods Cell Biol. 1977; 16:407-20. O'Farrell PH, O'Farrell PZ. PMID: 196157.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    133. High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 1975 May 25; 250(10):4007-21. O'Farrell PH. PMID: 236308; PMCID: PMC2874754.
      View in: PubMed   Mentions: 4160     Fields:    Translation:Cells
    134. Estrogen binding in the uteri of mammals with delayed implantation. Endocrinology. 1971 Apr; 88(4):1104-6. O'Farrell PH, Daniel JC. PMID: 5542406.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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