-
Coordinating transcription and replication to mitigate their conflicts in early Drosophila embryos. Cell Rep. 2022 10 18; 41(3):111507.
Cho CY, Kemp JP, Duronio RJ, O'Farrell PH. PMID: 36261005; PMCID: PMC9667882.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Mitigation of age-dependent accumulation of defective mitochondrial genomes. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2119009119.
Tsai PI, Korotkevich E, O'Farrell PH. PMID: 35881807; PMCID: PMC9351377.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila. Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2200780119.
Cho CY, Seller CA, O'Farrell PH. PMID: 35733247; PMCID: PMC9245680.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio. PLoS Biol. 2020 10; 18(10):e3000891.
Strong IJT, Lei X, Chen F, Yuan K, O'Farrell PH. PMID: 33090988; PMCID: PMC7608951.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations. Curr Biol. 2019 12 16; 29(24):4330-4336.e3.
Chiang AC, McCartney E, O'Farrell PH, Ma H. PMID: 31786061; PMCID: PMC6926476.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila. Genes Dev. 2019 04 01; 33(7-8):403-417.
Seller CA, Cho CY, O'Farrell PH. PMID: 30808658; PMCID: PMC6446540.
View in:
PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
-
Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 2018 05; 16(5):e2005687.
Seller CA, O'Farrell PH. PMID: 29746464; PMCID: PMC5963817.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research. Dis Model Mech. 2017 12 19; 10(12):1381-1389.
Duronio RJ, O'Farrell PH, Sluder G, Su TT. PMID: 29259023; PMCID: PMC5769611.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes. Curr Biol. 2017 Apr 03; 27(7):1033-1039.
Yu Z, O'Farrell PH, Yakubovich N, DeLuca SZ. PMID: 28318978; PMCID: PMC5391691.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
-
Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View. Trends Genet. 2016 08; 32(8):496-507.
Yuan K, Seller CA, Shermoen AW, O'Farrell PH. PMID: 27339317; PMCID: PMC4958567.
View in:
PubMed Mentions:
40 Fields:
Translation:
Animals
-
Selfish drive can trump function when animal mitochondrial genomes compete. Nat Genet. 2016 07; 48(7):798-802.
Ma H, O'Farrell PH. PMID: 27270106; PMCID: PMC4925267.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos. Genes Dev. 2016 Mar 01; 30(5):579-93.
Yuan K, O'Farrell PH. PMID: 26915820; PMCID: PMC4782051.
View in:
PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
-
Growing an Embryo from a Single Cell: A Hurdle in Animal Life. Cold Spring Harb Perspect Biol. 2015 Aug 07; 7(11).
O'Farrell PH. PMID: 26254311; PMCID: PMC4632664.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Selections that isolate recombinant mitochondrial genomes in animals. Elife. 2015 Aug 03; 4.
Ma H, O'Farrell PH. PMID: 26237110; PMCID: PMC4584245.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol. 2015 Mar 16; 25(6):811-816.
Yuan K, O'Farrell PH. PMID: 25754637; PMCID: PMC4412444.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014; 48:269-94.
Farrell JA, O'Farrell PH. PMID: 25195504; PMCID: PMC4484755.
View in:
PubMed Mentions:
103 Fields:
Translation:
Animals
-
Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7.
Ma H, Xu H, O'Farrell PH. PMID: 24614071; PMCID: PMC4091738.
View in:
PubMed Mentions:
57 Fields:
Translation:
Animals
-
Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3.
O'Farrell PH. PMID: 24568796.
View in:
PubMed Mentions: Fields:
-
Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5.
Yuan K, Shermoen AW, O'Farrell PH. PMID: 24556431; PMCID: PMC3977024.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
Farrell JA, O'Farrell PH. PMID: 23290551; PMCID: PMC4091758.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
Yuan K, Farrell JA, O'Farrell PH. PMID: 22965907; PMCID: PMC3444785.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 01; 26(7):714-25.
Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. PMID: 22431511; PMCID: PMC3323882.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
DeLuca SZ, O'Farrell PH. PMID: 22421049; PMCID: PMC3306594.
View in:
PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
-
Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
O'Farrell PH. PMID: 22084377; PMCID: PMC3203459.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 07; 20(23):2067-77.
Shermoen AW, McCleland ML, O'Farrell PH. PMID: 21074439; PMCID: PMC3108027.
View in:
PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
-
Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
Yakubovich N, Silva EA, O'Farrell PH. PMID: 20178753; PMCID: PMC2861863.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
O'Farrell PH. PMID: 20213891; PMCID: PMC2869091.
View in:
PubMed Mentions: Fields:
-
DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 05; 187(1):7-14.
McCleland ML, Shermoen AW, O'Farrell PH. PMID: 19786576; PMCID: PMC2762091.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
Dijkers PF, O'Farrell PH. PMID: 19625446; PMCID: PMC2743626.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 09; 184(5):639-46.
McCleland ML, Farrell JA, O'Farrell PH. PMID: 19273612; PMCID: PMC2686416.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. PMID: 19089394.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
O'Farrell PH. PMID: 19003855; PMCID: PMC2731566.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
Xu H, DeLuca SZ, O'Farrell PH. PMID: 18653897; PMCID: PMC2754248.
View in:
PubMed Mentions:
62 Fields:
Translation:
Animals
-
An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
Lee SJ, Feldman R, O'Farrell PH. PMID: 18653470; PMCID: PMC2555944.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41.
Hickson GR, O'Farrell PH. PMID: 18481976; PMCID: PMC2695931.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
-
RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54.
McCleland ML, O'Farrell PH. PMID: 18291653; PMCID: PMC2698964.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28; 180(2):285-94.
Hickson GR, O'Farrell PH. PMID: 18209105; PMCID: PMC2213597.
View in:
PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
-
Drosophila calcineurin promotes induction of innate immune responses. Curr Biol. 2007 Dec 04; 17(23):2087-93.
Dijkers PF, O'Farrell PH. PMID: 18060786; PMCID: PMC2180389.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006 Aug; 8(8):793-802.
Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, Andino R. PMID: 16862146; PMCID: PMC2731564.
View in:
PubMed Mentions:
196 Fields:
Translation:
AnimalsCells
-
Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006 Feb 21; 16(4):359-70.
Hickson GR, Echard A, O'Farrell PH. PMID: 16488869; PMCID: PMC1525334.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
-
Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006 Jan; 4(1):e4.
Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. PMID: 16336044; PMCID: PMC1310651.
View in:
PubMed Mentions:
120 Fields:
Translation:
Animals
-
Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol. 2004 Sep 21; 14(18):1685-93.
Echard A, Hickson GR, Foley E, O'Farrell PH. PMID: 15380073; PMCID: PMC2899696.
View in:
PubMed Mentions:
129 Fields:
Translation:
AnimalsCells
-
Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol. 2004 Aug; 2(8):E203.
Foley E, O'Farrell PH. PMID: 15221030; PMCID: PMC434151.
View in:
PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
-
Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol. 2004 Jan 06; 14(1):R35-45.
O'Farrell PH, Stumpff J, Su TT. PMID: 14711435; PMCID: PMC2712630.
View in:
PubMed Mentions:
100 Fields:
Translation:
Animals
-
Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 04; 4:9.
Hériché JK, Ang D, Bier E, O'Farrell PH. PMID: 12787468; PMCID: PMC161817.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol. 2003 Apr 15; 13(8):647-53.
Parry DH, Hickson GR, O'Farrell PH. PMID: 12699620; PMCID: PMC2749715.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
The degradation of two mitotic cyclins contributes to the timing of cytokinesis. Curr Biol. 2003 Mar 04; 13(5):373-83.
Echard A, O'Farrell PH. PMID: 12620185; PMCID: PMC2754242.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
-
Nitric oxide-induced suspended animation promotes survival during hypoxia. EMBO J. 2003 Feb 03; 22(3):580-7.
Teodoro RO, O'Farrell PH. PMID: 12554658; PMCID: PMC140754.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation. J Cell Sci. 2003 Jan 01; 116(Pt 1):137-43.
Vidwans SJ, Wong ML, O'Farrell PH. PMID: 12456723; PMCID: PMC2754245.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev. 2003 Jan 01; 17(1):115-25.
Foley E, O'Farrell PH. PMID: 12514104; PMCID: PMC195964.
View in:
PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
-
Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Curr Biol. 2002 May 14; 12(10):829-33.
Vidwans SJ, DiGregorio PJ, Shermoen AW, Foat B, Iwasa J, Yakubovich N, O'Farrell PH. PMID: 12015119; PMCID: PMC2754250.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 2001 Dec; 11(12):512-9.
O'Farrell PH. PMID: 11719058; PMCID: PMC2765372.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
-
Cell cycle roles for two 14-3-3 proteins during Drosophila development. J Cell Sci. 2001 Oct; 114(Pt 19):3445-54.
Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell PH, Purdy A. PMID: 11682604; PMCID: PMC2754241.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001 May 01; 11(9):671-83.
Parry DH, O'Farrell PH. PMID: 11369230; PMCID: PMC2875931.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
-
Conserved responses to oxygen deprivation. J Clin Invest. 2001 Mar; 107(6):671-4.
O'Farrell PH. PMID: 11254666; PMCID: PMC208955.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions. J Biol Chem. 2001 Jan 19; 276(3):1930-7.
DiGregorio PJ, Ubersax JA, O'Farrell PH. PMID: 11054409; PMCID: PMC2754243.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Genetics. 2000 May; 155(1):159-66.
Price D, Rabinovitch S, O'Farrell PH, Campbell SD. PMID: 10790391; PMCID: PMC1461082.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Comparative genomics of the eukaryotes. Science. 2000 Mar 24; 287(5461):2204-15.
Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S. PMID: 10731134; PMCID: PMC2754258.
View in:
PubMed Mentions:
502 Fields:
Translation:
HumansAnimalsCells
-
Mitotic regulators govern progress through steps in the centrosome duplication cycle. J Cell Biol. 1999 Dec 27; 147(7):1371-8.
Vidwans SJ, Wong ML, O'Farrell PH. PMID: 10613895; PMCID: PMC2174235.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol. 1999 Dec 02; 9(23):1392-402.
Foley E, O'Farrell PH, Sprenger F. PMID: 10607563; PMCID: PMC2754244.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei. Curr Biol. 1999 Nov 04; 9(21):1263-6.
Wilkie GS, Shermoen AW, O'Farrell PH, Davis I. PMID: 10556096; PMCID: PMC2754251.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Cytoskeleton: centrosom-in absentia. Curr Biol. 1999 Oct 21; 9(20):R764-6.
Vidwans SJ, O'Farrell PH. PMID: 10531022; PMCID: PMC2754240.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events. Curr Biol. 1999 Aug 26; 9(16):919-22.
Su TT, Campbell SD, O'Farrell PH. PMID: 10469601; PMCID: PMC2749710.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Cell. 1999 Jul 09; 98(1):105-14.
Wingrove JA, O'Farrell PH. PMID: 10412985; PMCID: PMC2754235.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
-
Size control: cell proliferation does not equal growth. Curr Biol. 1998 Sep 24; 8(19):R687-9.
Su TT, O'Farrell PH. PMID: 9768354; PMCID: PMC2754256.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 1998 May 15; 12(10):1495-503.
Su TT, Sprenger F, DiGregorio PJ, Campbell SD, O'Farrell PH. PMID: 9585509; PMCID: PMC316833.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
-
The cell cycle program in germ cells of the Drosophila embryo. Dev Biol. 1998 Apr 15; 196(2):160-70.
Su TT, Campbell SD, O'Farrell PH. PMID: 9576829.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998 Feb 12; 8(4):235-8.
Follette PJ, Duronio RJ, O'Farrell PH. PMID: 9501987; PMCID: PMC2754236.
View in:
PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
-
Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J Cell Biol. 1998 Feb 09; 140(3):451-60.
Su TT, O'Farrell PH. PMID: 9456309; PMCID: PMC2140170.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998 Jan; 18(1):141-51.
Duronio RJ, Bonnette PC, O'Farrell PH. PMID: 9418862; PMCID: PMC121467.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J Cell Biol. 1997 Oct 06; 139(1):13-21.
Su TT, O'Farrell PH. PMID: 9314525; PMCID: PMC2139827.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol. 1997 Jul 01; 7(7):488-99.
Sprenger F, Yakubovich N, O'Farrell PH. PMID: 9210381; PMCID: PMC2754254.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. Gene. 1997 Jun 19; 192(2):283-9.
Su TT, Yakubovich N, O'Farrell PH. PMID: 9224901; PMCID: PMC2753454.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Limb morphogenesis: connections between patterning and growth. Curr Biol. 1997 Mar 01; 7(3):R186-95.
Serrano N, O'Farrell PH. PMID: 9162486; PMCID: PMC2749718.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Connecting cell behavior to patterning: lessons from the cell cycle. Cell. 1997 Feb 07; 88(3):309-14.
Follette PJ, O'Farrell PH. PMID: 9039257; PMCID: PMC2754257.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Cdks and the Drosophila cell cycle. Curr Opin Genet Dev. 1997 Feb; 7(1):17-22.
Follette PJ, O'Farrell PH. PMID: 9024630; PMCID: PMC2753438.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
E2F-induced S phase requires cyclin E. Genes Dev. 1996 Oct 01; 10(19):2505-13.
Duronio RJ, Brook A, Dyson N, O'Farrell PH. PMID: 8843201.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
-
Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. Mol Biol Cell. 1996 Apr; 7(4):505-13.
Leclerc V, Tassan JP, O'Farrell PH, Nigg EA, Léopold P. PMID: 8730095; PMCID: PMC275905.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Drosophila MCM protein complexes. Mol Biol Cell. 1996 Feb; 7(2):319-29.
Su TT, Feger G, O'Farrell PH. PMID: 8688561; PMCID: PMC275882.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol Biol Cell. 1995 Oct; 6(10):1333-47.
Campbell SD, Sprenger F, Edgar BA, O'Farrell PH. PMID: 8573790; PMCID: PMC301291.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
-
A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev Biol. 1995 Aug; 170(2):726-9.
Davis I, Girdham CH, O'Farrell PH. PMID: 7649398.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 1995 Jul 15; 9(14):1709-15.
Treisman JE, Follette PJ, O'Farrell PH, Rubin GM. PMID: 7622035.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Qualifying for the license to replicate. Cell. 1995 Jun 16; 81(6):825-8.
Su TT, Follette PJ, O'Farrell PH. PMID: 7781058; PMCID: PMC2755094.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995 Jun 15; 9(12):1445-55.
Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. PMID: 7601349.
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PubMed Mentions:
111 Fields:
Translation:
AnimalsCells
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Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995 Jun 15; 9(12):1456-68.
Duronio RJ, O'Farrell PH. PMID: 7601350.
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PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
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Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development. 1994 Nov; 120(11):3131-43.
Edgar BA, Lehman DA, O'Farrell PH. PMID: 7720557; PMCID: PMC2753456.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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The making of a maggot: patterning the Drosophila embryonic epidermis. Curr Opin Genet Dev. 1994 Aug; 4(4):529-34.
DiNardo S, Heemskerk J, Dougan S, O'Farrell PH. PMID: 7950320; PMCID: PMC2873142.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev Biol. 1994 Jul; 164(1):328-31.
Vincent JP, Girdham CH, O'Farrell PH. PMID: 8026635.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994 Jun; 120(6):1503-15.
Duronio RJ, O'Farrell PH. PMID: 8050359; PMCID: PMC2753441.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Developmental biology. Unanimity waits in the wings. Nature. 1994 Mar 17; 368(6468):188-9.
O'Farrell PH. PMID: 8145815; PMCID: PMC2763625.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev. 1994 Feb 15; 8(4):440-52.
Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell PH. PMID: 7510257; PMCID: PMC6520052.
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PubMed Mentions:
126 Fields:
Translation:
AnimalsCells
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The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis. Methods Cell Biol. 1994; 44:533-43.
Girdham CH, O'Farrell PH. PMID: 7535883.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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A universal target sequence is bound in vitro by diverse homeodomains. Mech Dev. 1993 Sep; 43(1):57-70.
Kalionis B, O'Farrell PH. PMID: 7902124; PMCID: PMC2755072.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10.
Moazed D, O'Farrell PH. PMID: 1363229; PMCID: PMC2755082.
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PubMed Mentions:
51 Fields:
Translation:
Animals
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Developmental biology. Big genes and little genes and deadlines for transcription. Nature. 1992 Oct 01; 359(6394):366-7.
O'Farrell PH. PMID: 1406945; PMCID: PMC2754300.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Cell cycle control: many ways to skin a cat. Trends Cell Biol. 1992 Jun; 2(6):159-63.
O'Farrell PH. PMID: 14731984.
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PubMed Mentions:
10 Fields:
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The state of engrailed expression is not clonally transmitted during early Drosophila development. Cell. 1992 Mar 06; 68(5):923-31.
Vincent JP, O'Farrell PH. PMID: 1547492; PMCID: PMC2753444.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Progression of the cell cycle through mitosis leads to abortion of nascent transcripts. Cell. 1991 Oct 18; 67(2):303-10.
Shermoen AW, O'Farrell PH. PMID: 1680567; PMCID: PMC2755073.
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PubMed Mentions:
170 Fields:
Translation:
AnimalsCells
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An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell. 1991 Sep 20; 66(6):1207-16.
Léopold P, O'Farrell PH. PMID: 1833067; PMCID: PMC2753436.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature. 1991 Aug 01; 352(6334):404-10.
Heemskerk J, DiNardo S, Kostriken R, O'Farrell PH. PMID: 1861720; PMCID: PMC2755087.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Active repression of transcription by the engrailed homeodomain protein. EMBO J. 1991 Jun; 10(6):1427-33.
Jaynes JB, O'Farrell PH. PMID: 1673924; PMCID: PMC452804.
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PubMed Mentions:
72 Fields:
Translation:
AnimalsCells
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Exploring the role of Drosophila cyclin A in the regulation of S phase. Cold Spring Harb Symp Quant Biol. 1991; 56:465-75.
Lehner CF, Yakubovich N, O'Farrell PH. PMID: 1840259.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 1990 Nov; 9(11):3573-81.
Lehner CF, O'Farrell PH. PMID: 2120045; PMCID: PMC552108.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell. 1990 Aug 10; 62(3):469-80.
Edgar BA, O'Farrell PH. PMID: 2199063; PMCID: PMC2753418.
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PubMed Mentions:
150 Fields:
Translation:
AnimalsCells
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A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J. 1990 Aug; 9(8):2573-8.
Vincent JP, Kassis JA, O'Farrell PH. PMID: 1973384; PMCID: PMC552289.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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The roles of Drosophila cyclins A and B in mitotic control. Cell. 1990 May 04; 61(3):535-47.
Lehner CF, O'Farrell PH. PMID: 2139805; PMCID: PMC2753431.
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PubMed Mentions:
147 Fields:
Translation:
AnimalsCells
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Directing cell division during development. Science. 1989 Nov 03; 246(4930):635-40.
O'Farrell PH, Edgar BA, Lakich D, Lehner CF. PMID: 2683080.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol. 1989 Oct; 9(10):4304-11.
Kassis JA, Desplan C, Wright DK, O'Farrell PH. PMID: 2573829; PMCID: PMC362511.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Genetic control of cell division patterns in the Drosophila embryo. Cell. 1989 Apr 07; 57(1):177-87.
Edgar BA, O'Farrell PH. PMID: 2702688; PMCID: PMC2755076.
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PubMed Mentions:
172 Fields:
Translation:
AnimalsCells
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Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell. 1989 Mar 24; 56(6):957-68.
Lehner CF, O'Farrell PH. PMID: 2564316; PMCID: PMC2753420.
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PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature. 1988 Dec 22-29; 336(6201):744-9.
Jaynes JB, O'Farrell PH. PMID: 2905023; PMCID: PMC2868829.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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The sequence specificity of homeodomain-DNA interaction. Cell. 1988 Sep 23; 54(7):1081-90.
Desplan C, Theis J, O'Farrell PH. PMID: 3046753; PMCID: PMC2753412.
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PubMed Mentions:
166 Fields:
Translation:
AnimalsCells
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Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature. 1988 Apr 14; 332(6165):604-9.
DiNardo S, Sher E, Heemskerk-Jongens J, Kassis JA, O'Farrell PH. PMID: 3282172; PMCID: PMC2753417.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. Genes Dev. 1988 Mar; 2(3):350-60.
Carroll SB, DiNardo S, O'Farrell PH, White RA, Scott MP. PMID: 2897943.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1987 Dec; 1(10):1212-25.
DiNardo S, O'Farrell PH. PMID: 3123316.
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PubMed Mentions:
58 Fields:
Translation:
Animals
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Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J. 1986 Dec 20; 5(13):3583-9.
Kassis JA, Poole SJ, Wright DK, O'Farrell PH. PMID: 2881781; PMCID: PMC1167397.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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Spatial programming of gene expression in early Drosophila embryogenesis. Annu Rev Cell Biol. 1986; 2:49-80.
Scott MP, O'Farrell PH. PMID: 2881561.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis. Mol Cell Biol. 1985 Dec; 5(12):3600-9.
Kassis JA, Wong ML, O'Farrell PH. PMID: 3939321; PMCID: PMC369191.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985 Dec 19-1986 Jan 1; 318(6047):630-5.
Desplan C, Theis J, O'Farrell PH. PMID: 4079979; PMCID: PMC2880619.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell. 1985 Nov; 43(1):59-69.
DiNardo S, Kuner JM, Theis J, O'Farrell PH. PMID: 3935318; PMCID: PMC2879874.
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PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
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Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell. 1985 Aug; 42(1):309-16.
Kuner JM, Nakanishi M, Ali Z, Drees B, Gustavson E, Theis J, Kauvar L, Kornberg T, O'Farrell PH. PMID: 2990728; PMCID: PMC2753415.
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PubMed Mentions:
37 Fields:
Translation:
Animals
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Separation techniques based on the opposition of two counteracting forces to produce a dynamic equilibrium. Science. 1985 Mar 29; 227(4694):1586-9.
O'farrell PH. PMID: 17795350; PMCID: PMC2896869.
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PubMed Mentions:
2 Fields:
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Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein. Cold Spring Harb Symp Quant Biol. 1985; 50:235-42.
O'Farrell PH, Desplan C, DiNardo S, Kassis JA, Kuner JM, Sher E, Theis J, Wright D. PMID: 3006988.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells. Mol Cell Biol. 1983 Aug; 3(8):1460-7.
Ivarie RD, Schacter BS, O'Farrell PH. PMID: 6621533; PMCID: PMC369992.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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A restriction map of the bacteriophage T4 genome. Mol Gen Genet. 1980; 179(2):421-435.
O'Farrell PH, Kutter E, Nakanishi M. PMID: 6258018; PMCID: PMC2868831.
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PubMed Mentions:
131 Fields:
Translation:
Cells
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The glucocorticoid domain of response: measurement of pleiotropic cellular responses by two-dimensional gel electrophoresis. Monogr Endocrinol. 1979; 12:189-201.
O'Farrell PH, Ivarie RD. PMID: 226869.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Isolation and characterization of ColE1-derived plasmid copy-number mutant. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5869-73.
Gelfand DH, Shepard HM, O'Farrell PH, Polisky B. PMID: 104293; PMCID: PMC393077.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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The suppression of defective translation by ppGpp and its role in the stringent response. Cell. 1978 Jul; 14(3):545-57.
O'Farrell PH. PMID: 357011.
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PubMed Mentions:
78 Fields:
Translation:
Cells
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The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins. Cell. 1978 Jan; 13(1):41-55.
Ivarie RD, O'Farrell PH. PMID: 23216.
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PubMed Mentions:
41 Fields:
Translation:
Cells
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High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 1977 Dec; 12(4):1133-41.
O'Farrell PZ, Goodman HM, O'Farrell PH. PMID: 23215.
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PubMed Mentions:
865 Fields:
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Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Cell. 1977 Mar; 10(3):381-91.
Steinberg RA, O'Farrell PH, Friedrich U, Coffino P. PMID: 191196.
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PubMed Mentions:
39 Fields:
Translation:
Cells
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Two-dimensional polyacrylamide gel electrophoretic fractionation. Methods Cell Biol. 1977; 16:407-20.
O'Farrell PH, O'Farrell PZ. PMID: 196157.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 1975 May 25; 250(10):4007-21.
O'Farrell PH. PMID: 236308; PMCID: PMC2874754.
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PubMed Mentions:
4163 Fields:
Translation:
Cells
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Estrogen binding in the uteri of mammals with delayed implantation. Endocrinology. 1971 Apr; 88(4):1104-6.
O'Farrell PH, Daniel JC. PMID: 5542406.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells