Patrick O'Farrell, PhD

Address600 16th St
San Francisco CA 94158
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    Collapse Overview 
    Collapse Overview
    We are interested in the decoding of biological information to produce functional structures at the level of cells and organisms. We focus on the control of the cell cycle during development using Drosophila genetics, molecular biology and fancy microscopy. We are examining temporal coordination of early embryonic cell cycles with development. Having found that slowing early rapid cell cycles is due to prolongation of S phase, the period of DNA replication, we are studying this control. This prolongation of S phase is tightly integrated with a developmental program of chromatin changes that introduces epigenetic controls. Using GFP tagged proteins marking molecular hallmarks of these events, we are able to watch them occur in real time in embryos and to probe the processes that regulate their onset.

    A newer effort explores the genetics and biology of the mitochondria. Our principle interest is in a newly recognized mystery. The mitochondrial genome encodes functions that benefit the host rather than propagation and transmission of the mitochondrial genome. This would not be problem if evolution of this genome were based on the usual selection for fit organisms as Darwin suggests. However, we found that selection is based on the ability of genomes to compete for transmission from one generation to the next. This ought to select for selfish genes promoting genome success. To achieve the real outcome, the host manipulates the competition to favor genes to its benefit. We are trying to understand how this managed evolution is achieved.

    Collapse Research 
    Collapse Research Activities and Funding
    Host management of the mitochondrial genome
    NIH/NIGMS R01GM120005Sep 19, 2011 - Jun 30, 2020
    Role: Principal Investigator
    The genetic basis for tissue specific sensitivities to mitochondrial stress
    NIH/NIEHS R01ES020725Sep 19, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Nitric Oxide Signaling in Hypoxia and Immunity in Drosophila
    NIH/NIGMS R01GM086854Mar 1, 2000 - Jul 31, 2013
    Role: Principal Investigator
    Nitric Oxide and Responses to Hypoxia in Drosophila
    NIH/NIAID R01AI060102Mar 1, 2000 - Sep 29, 2008
    Role: Principal Investigator
    NIH/NIGMS R01GM060988Mar 1, 2000 - Apr 14, 2004
    Role: Principal Investigator
    Developmental Programs of Cell Cycle Control
    NIH/NIGMS R37GM037193Jul 1, 1986 - Jun 30, 2020
    Role: Principal Investigator
    Developmental Programs of Cell Cycle Control
    NIH/NIGMS R01GM037193Jul 1, 1986 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu Z, O'Farrell P, Yakubovich N, DeLuca SZ. The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes. Curr Biol. 2017 Apr 03; 27(7):1033-1039. PMID: 28318978.
      View in: PubMed
    2. Yuan K, Seller CA, Shermoen AW, O'Farrell P. Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View. Trends Genet. 2016 Aug; 32(8):496-507. PMID: 27339317; PMCID: PMC4958567 [Available on 08/01/17].
    3. Ma H, O'Farrell P. Selfish drive can trump function when animal mitochondrial genomes compete. Nat Genet. 2016 Jul; 48(7):798-802. PMID: 27270106; PMCID: PMC4925267 [Available on 12/06/16].
    4. Yuan K, O'Farrell P. TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos. Genes Dev. 2016 Mar 01; 30(5):579-93. PMID: 26915820; PMCID: PMC4782051.
    5. O'Farrell P. Growing an Embryo from a Single Cell: A Hurdle in Animal Life. Cold Spring Harb Perspect Biol. 2015 Aug 07; 7(11). PMID: 26254311.
      View in: PubMed
    6. Ma H, O'Farrell P. Selections that isolate recombinant mitochondrial genomes in animals. Elife. 2015 Aug 03; 4. PMID: 26237110; PMCID: PMC4584245.
    7. Yuan K, O'Farrell P. Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol. 2015 Mar 16; 25(6):811-6. PMID: 25754637; PMCID: PMC4412444.
    8. Farrell JA, O'Farrell P. From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014; 48:269-94. PMID: 25195504; PMCID: PMC4484755.
    9. Ma H, Xu H, O'Farrell P. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7. PMID: 24614071; PMCID: PMC4091738.
    10. O'Farrell P. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3. PMID: 24568796.
      View in: PubMed
    11. Yuan K, Shermoen AW, O'Farrell P. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5. PMID: 24556431; PMCID: PMC3977024.
    12. Yuan K, Farrell JA, O'Farrell P. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80. PMID: 22965907; PMCID: PMC3444785.
    13. Farrell JA, Shermoen AW, Yuan K, O'Farrell P. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 01; 26(7):714-25. PMID: 22431511; PMCID: PMC3323882.
    14. DeLuca SZ, O'Farrell P. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8. PMID: 22421049; PMCID: PMC3306594.
    15. O'Farrell P. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507. PMID: 22084377; PMCID: PMC3203459.
    16. Shermoen AW, McCleland ML, O'Farrell P. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 07; 20(23):2067-77. PMID: 21074439; PMCID: PMC3108027.
    17. Yakubovich N, Silva EA, O'Farrell P. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2. PMID: 20178753; PMCID: PMC2861863.
    18. O'Farrell P. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4. PMID: 20213891; PMCID: PMC2869091.
    19. McCleland ML, Shermoen AW, O'Farrell P. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 05; 187(1):7-14. PMID: 19786576; PMCID: PMC2762091.
    20. Dijkers PF, O'Farrell P. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90. PMID: 19625446; PMCID: PMC2743626.
    21. McCleland ML, Farrell JA, O'Farrell P. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 09; 184(5):639-46. PMID: 19273612; PMCID: PMC2686416.
    22. Stroschein-Stevenson SL, Foley E, O'Farrell P, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58. PMID: 19089394.
      View in: PubMed
    23. O'Farrell P. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52. PMID: 19003855; PMCID: PMC2731566.
    24. Xu H, DeLuca SZ, O'Farrell P. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7. PMID: 18653897; PMCID: PMC2754248.
    25. Lee SJ, Feldman R, O'Farrell P. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61. PMID: 18653470; PMCID: PMC2555944.
    26. Hickson GR, O'Farrell P. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41. PMID: 18481976; PMCID: PMC2695931.
    27. McCleland ML, O'Farrell P. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54. PMID: 18291653; PMCID: PMC2698964.
    28. Hickson GR, O'Farrell P. Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28; 180(2):285-94. PMID: 18209105; PMCID: PMC2213597.
    29. Dijkers PF, O'Farrell P. Drosophila calcineurin promotes induction of innate immune responses. Curr Biol. 2007 Dec 04; 17(23):2087-93. PMID: 18060786; PMCID: PMC2180389.
    30. Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell P, Andino R. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006 Aug; 8(8):793-802. PMID: 16862146; PMCID: PMC2731564.
    31. Hickson GR, Echard A, O'Farrell P. Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006 Feb 21; 16(4):359-70. PMID: 16488869; PMCID: PMC1525334.
    32. Stroschein-Stevenson SL, Foley E, O'Farrell P, Johnson AD. Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006 Jan; 4(1):e4. PMID: 16336044; PMCID: PMC1310651.
    33. Echard A, Hickson GR, Foley E, O'Farrell P. Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol. 2004 Sep 21; 14(18):1685-93. PMID: 15380073; PMCID: PMC2899696.
    34. Foley E, O'Farrell P. Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol. 2004 Aug; 2(8):E203. PMID: 15221030; PMCID: PMC434151.
    35. O'Farrell P, Stumpff J, Su TT. Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol. 2004 Jan 06; 14(1):R35-45. PMID: 14711435; PMCID: PMC2712630.
    36. Hériché JK, Ang D, Bier E, O'Farrell P. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 04; 4:9. PMID: 12787468; PMCID: PMC161817.
    37. Parry DH, Hickson GR, O'Farrell P. Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol. 2003 Apr 15; 13(8):647-53. PMID: 12699620; PMCID: PMC2749715.
    38. Echard A, O'Farrell P. The degradation of two mitotic cyclins contributes to the timing of cytokinesis. Curr Biol. 2003 Mar 04; 13(5):373-83. PMID: 12620185; PMCID: PMC2754242.
    39. Teodoro RO, O'Farrell P. Nitric oxide-induced suspended animation promotes survival during hypoxia. EMBO J. 2003 Feb 03; 22(3):580-7. PMID: 12554658; PMCID: PMC140754.
    40. Vidwans SJ, Wong ML, O'Farrell P. Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation. J Cell Sci. 2003 Jan 01; 116(Pt 1):137-43. PMID: 12456723; PMCID: PMC2754245.
    41. Foley E, O'Farrell P. Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev. 2003 Jan 01; 17(1):115-25. PMID: 12514104; PMCID: PMC195964.
    42. Vidwans SJ, DiGregorio PJ, Shermoen AW, Foat B, Iwasa J, Yakubovich N, O'Farrell P. Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Curr Biol. 2002 May 14; 12(10):829-33. PMID: 12015119; PMCID: PMC2754250.
    43. O'Farrell P. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 2001 Dec; 11(12):512-9. PMID: 11719058; PMCID: PMC2765372.
    44. Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell P, Purdy A. Cell cycle roles for two 14-3-3 proteins during Drosophila development. J Cell Sci. 2001 Oct; 114(Pt 19):3445-54. PMID: 11682604; PMCID: PMC2754241.
    45. Parry DH, O'Farrell P. The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001 May 01; 11(9):671-83. PMID: 11369230; PMCID: PMC2875931.
    46. O'Farrell P. Conserved responses to oxygen deprivation. J Clin Invest. 2001 Mar; 107(6):671-4. PMID: 11254666; PMCID: PMC208955.
    47. DiGregorio PJ, Ubersax JA, O'Farrell P. Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions. J Biol Chem. 2001 Jan 19; 276(3):1930-7. PMID: 11054409; PMCID: PMC2754243.
    48. Price D, Rabinovitch S, O'Farrell P, Campbell SD. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Genetics. 2000 May; 155(1):159-66. PMID: 10790391; PMCID: PMC1461082.
    49. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell P, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S. Comparative genomics of the eukaryotes. Science. 2000 Mar 24; 287(5461):2204-15. PMID: 10731134; PMCID: PMC2754258.
    50. Vidwans SJ, Wong ML, O'Farrell P. Mitotic regulators govern progress through steps in the centrosome duplication cycle. J Cell Biol. 1999 Dec 27; 147(7):1371-8. PMID: 10613895; PMCID: PMC2174235.
    51. Foley E, O'Farrell P, Sprenger F. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr Biol. 1999 Dec 02; 9(23):1392-402. PMID: 10607563; PMCID: PMC2754244.
    52. Wilkie GS, Shermoen AW, O'Farrell P, Davis I. Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei. Curr Biol. 1999 Nov 04; 9(21):1263-6. PMID: 10556096; PMCID: PMC2754251.
    53. Vidwans SJ, O'Farrell P. Cytoskeleton: centrosom-in absentia. Curr Biol. 1999 Oct 21; 9(20):R764-6. PMID: 10531022; PMCID: PMC2754240.
    54. Su TT, Campbell SD, O'Farrell P. Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events. Curr Biol. 1999 Aug 26; 9(16):919-22. PMID: 10469601; PMCID: PMC2749710.
    55. Wingrove JA, O'Farrell P. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila. Cell. 1999 Jul 09; 98(1):105-14. PMID: 10412985; PMCID: PMC2754235.
    56. Su TT, O'Farrell P. Size control: cell proliferation does not equal growth. Curr Biol. 1998 Sep 24; 8(19):R687-9. PMID: 9768354; PMCID: PMC2754256.
    57. Su TT, Sprenger F, DiGregorio PJ, Campbell SD, O'Farrell P. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 1998 May 15; 12(10):1495-503. PMID: 9585509; PMCID: PMC316833.
    58. Su TT, Campbell SD, O'Farrell P. The cell cycle program in germ cells of the Drosophila embryo. Dev Biol. 1998 Apr 15; 196(2):160-70. PMID: 9576829.
      View in: PubMed
    59. Follette PJ, Duronio RJ, O'Farrell P. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998 Feb 12; 8(4):235-8. PMID: 9501987; PMCID: PMC2754236.
    60. Su TT, O'Farrell P. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J Cell Biol. 1998 Feb 09; 140(3):451-60. PMID: 9456309; PMCID: PMC2140170.
    61. Duronio RJ, Bonnette PC, O'Farrell P. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998 Jan; 18(1):141-51. PMID: 9418862; PMCID: PMC121467.
    62. Su TT, O'Farrell P. Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J Cell Biol. 1997 Oct 06; 139(1):13-21. PMID: 9314525; PMCID: PMC2139827.
    63. Sprenger F, Yakubovich N, O'Farrell P. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr Biol. 1997 Jul 01; 7(7):488-99. PMID: 9210381; PMCID: PMC2754254.
    64. Su TT, Yakubovich N, O'Farrell P. Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. Gene. 1997 Jun 19; 192(2):283-9. PMID: 9224901; PMCID: PMC2753454.
    65. Serrano N, O'Farrell P. Limb morphogenesis: connections between patterning and growth. Curr Biol. 1997 Mar 01; 7(3):R186-95. PMID: 9162486; PMCID: PMC2749718.
    66. Follette PJ, O'Farrell P. Connecting cell behavior to patterning: lessons from the cell cycle. Cell. 1997 Feb 07; 88(3):309-14. PMID: 9039257; PMCID: PMC2754257.
    67. Follette PJ, O'Farrell P. Cdks and the Drosophila cell cycle. Curr Opin Genet Dev. 1997 Feb; 7(1):17-22. PMID: 9024630; PMCID: PMC2753438.
    68. Duronio RJ, Brook A, Dyson N, O'Farrell P. E2F-induced S phase requires cyclin E. Genes Dev. 1996 Oct 01; 10(19):2505-13. PMID: 8843201.
      View in: PubMed
    69. Leclerc V, Tassan JP, O'Farrell P, Nigg EA, Léopold P. Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II. Mol Biol Cell. 1996 Apr; 7(4):505-13. PMID: 8730095; PMCID: PMC275905.
    70. Su TT, Feger G, O'Farrell P. Drosophila MCM protein complexes. Mol Biol Cell. 1996 Feb; 7(2):319-29. PMID: 8688561; PMCID: PMC275882.
    71. O'Farrell P. Hydrophobic interaction chromatography. Methods Mol Biol. 1996; 59:151-5. PMID: 8798195.
      View in: PubMed
    72. Campbell SD, Sprenger F, Edgar BA, O'Farrell P. Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol Biol Cell. 1995 Oct; 6(10):1333-47. PMID: 8573790; PMCID: PMC301291.
    73. Davis I, Girdham CH, O'Farrell P. A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev Biol. 1995 Aug; 170(2):726-9. PMID: 7649398.
      View in: PubMed
    74. Treisman JE, Follette PJ, O'Farrell P, Rubin GM. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 1995 Jul 15; 9(14):1709-15. PMID: 7622035.
      View in: PubMed
    75. Su TT, Follette PJ, O'Farrell P. Qualifying for the license to replicate. Cell. 1995 Jun 16; 81(6):825-8. PMID: 7781058; PMCID: PMC2755094.
    76. Duronio RJ, O'Farrell P, Xie JE, Brook A, Dyson N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995 Jun 15; 9(12):1445-55. PMID: 7601349.
      View in: PubMed
    77. Duronio RJ, O'Farrell P. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995 Jun 15; 9(12):1456-68. PMID: 7601350.
      View in: PubMed
    78. Edgar BA, Lehman DA, O'Farrell P. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development. 1994 Nov; 120(11):3131-43. PMID: 7720557; PMCID: PMC2753456.
    79. DiNardo S, Heemskerk J, Dougan S, O'Farrell P. The making of a maggot: patterning the Drosophila embryonic epidermis. Curr Opin Genet Dev. 1994 Aug; 4(4):529-34. PMID: 7950320; PMCID: PMC2873142.
    80. Vincent JP, Girdham CH, O'Farrell P. A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev Biol. 1994 Jul; 164(1):328-31. PMID: 8026635.
      View in: PubMed
    81. Duronio RJ, O'Farrell P. Developmental control of a G1-S transcriptional program in Drosophila. Development. 1994 Jun; 120(6):1503-15. PMID: 8050359; PMCID: PMC2753441.
    82. O'Farrell P. Developmental biology. Unanimity waits in the wings. Nature. 1994 Mar 17; 368(6468):188-9. PMID: 8145815; PMCID: PMC2763625.
    83. Edgar BA, Sprenger F, Duronio RJ, Leopold P, O'Farrell P. Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev. 1994 Feb 15; 8(4):440-52. PMID: 7510257.
      View in: PubMed
    84. Girdham CH, O'Farrell P. The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis. Methods Cell Biol. 1994; 44:533-43. PMID: 7535883.
      View in: PubMed
    85. Kalionis B, O'Farrell P. A universal target sequence is bound in vitro by diverse homeodomains. Mech Dev. 1993 Sep; 43(1):57-70. PMID: 7902124; PMCID: PMC2755072.
    86. Moazed D, O'Farrell P. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10. PMID: 1363229; PMCID: PMC2755082.
    87. O'Farrell P. Developmental biology. Big genes and little genes and deadlines for transcription. Nature. 1992 Oct 01; 359(6394):366-7. PMID: 1406945; PMCID: PMC2754300.
    88. O'Farrell P. Cell cycle control: many ways to skin a cat. Trends Cell Biol. 1992 Jun; 2(6):159-63. PMID: 14731984.
      View in: PubMed
    89. Vincent JP, O'Farrell P. The state of engrailed expression is not clonally transmitted during early Drosophila development. Cell. 1992 Mar 06; 68(5):923-31. PMID: 1547492; PMCID: PMC2753444.
    90. Shermoen AW, O'Farrell P. Progression of the cell cycle through mitosis leads to abortion of nascent transcripts. Cell. 1991 Oct 18; 67(2):303-10. PMID: 1680567; PMCID: PMC2755073.
    91. Léopold P, O'Farrell P. An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell. 1991 Sep 20; 66(6):1207-16. PMID: 1833067; PMCID: PMC2753436.
    92. Heemskerk J, DiNardo S, Kostriken R, O'Farrell P. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature. 1991 Aug 01; 352(6334):404-10. PMID: 1861720; PMCID: PMC2755087.
    93. Jaynes JB, O'Farrell P. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 1991 Jun; 10(6):1427-33. PMID: 1673924; PMCID: PMC452804.
    94. Lehner CF, Yakubovich N, O'Farrell P. Exploring the role of Drosophila cyclin A in the regulation of S phase. Cold Spring Harb Symp Quant Biol. 1991; 56:465-75. PMID: 1840259.
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    95. O'Farrell P, Léopold P. A consensus of cyclin sequences reveals homology with the ras oncogene. Cold Spring Harb Symp Quant Biol. 1991; 56:83-92. PMID: 1840269.
      View in: PubMed
    96. Lehner CF, O'Farrell P. Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 1990 Nov; 9(11):3573-81. PMID: 2120045; PMCID: PMC552108.
    97. Edgar BA, O'Farrell P. The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell. 1990 Aug 10; 62(3):469-80. PMID: 2199063; PMCID: PMC2753418.
    98. Vincent JP, Kassis JA, O'Farrell P. A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J. 1990 Aug; 9(8):2573-8. PMID: 1973384; PMCID: PMC552289.
    99. Lehner CF, O'Farrell P. The roles of Drosophila cyclins A and B in mitotic control. Cell. 1990 May 04; 61(3):535-47. PMID: 2139805; PMCID: PMC2753431.
    100. O'Farrell P, Edgar BA, Lakich D, Lehner CF. Directing cell division during development. Science. 1989 Nov 03; 246(4930):635-40. PMID: 2683080.
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    101. Kassis JA, Desplan C, Wright DK, O'Farrell P. Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol. 1989 Oct; 9(10):4304-11. PMID: 2573829; PMCID: PMC362511.
    102. Edgar BA, O'Farrell P. Genetic control of cell division patterns in the Drosophila embryo. Cell. 1989 Apr 07; 57(1):177-87. PMID: 2702688; PMCID: PMC2755076.
    103. Lehner CF, O'Farrell P. Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell. 1989 Mar 24; 56(6):957-68. PMID: 2564316; PMCID: PMC2753420.
    104. Jaynes JB, O'Farrell P. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature. 1988 Dec 22-29; 336(6201):744-9. PMID: 2905023; PMCID: PMC2868829.
    105. Desplan C, Theis J, O'Farrell P. The sequence specificity of homeodomain-DNA interaction. Cell. 1988 Sep 23; 54(7):1081-90. PMID: 3046753; PMCID: PMC2753412.
    106. DiNardo S, Sher E, Heemskerk-Jongens J, Kassis JA, O'Farrell P. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature. 1988 Apr 14; 332(6165):604-9. PMID: 3282172; PMCID: PMC2753417.
    107. Carroll SB, DiNardo S, O'Farrell P, White RA, Scott MP. Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. Genes Dev. 1988 Mar; 2(3):350-60. PMID: 2897943.
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    108. DiNardo S, O'Farrell P. Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1987 Dec; 1(10):1212-25. PMID: 3123316.
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    109. Kassis JA, Poole SJ, Wright DK, O'Farrell P. Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J. 1986 Dec 20; 5(13):3583-9. PMID: 2881781; PMCID: PMC1167397.
    110. Scott MP, O'Farrell P. Spatial programming of gene expression in early Drosophila embryogenesis. Annu Rev Cell Biol. 1986; 2:49-80. PMID: 2881561.
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    111. Desplan C, Theis J, O'Farrell P. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985 Dec 19-1986 Jan 1; 318(6047):630-5. PMID: 4079979; PMCID: PMC2880619.
    112. Kassis JA, Wong ML, O'Farrell P. Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis. Mol Cell Biol. 1985 Dec; 5(12):3600-9. PMID: 3939321; PMCID: PMC369191.
    113. DiNardo S, Kuner JM, Theis J, O'Farrell P. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell. 1985 Nov; 43(1):59-69. PMID: 3935318; PMCID: PMC2879874.
    114. Kuner JM, Nakanishi M, Ali Z, Drees B, Gustavson E, Theis J, Kauvar L, Kornberg T, O'Farrell P. Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell. 1985 Aug; 42(1):309-16. PMID: 2990728; PMCID: PMC2753415.
    115. O'Farrell P, Desplan C, DiNardo S, Kassis JA, Kuner JM, Sher E, Theis J, Wright D. Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein. Cold Spring Harb Symp Quant Biol. 1985; 50:235-42. PMID: 3006988.
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    116. Kornberg T, Sidén I, O'Farrell P, Simon M. The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression. Cell. 1985 Jan; 40(1):45-53. PMID: 3917856.
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    117. Ivarie RD, Schacter BS, O'Farrell P. The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells. Mol Cell Biol. 1983 Aug; 3(8):1460-7. PMID: 6621533; PMCID: PMC369992.
    118. Jan LY, Barbel S, Timpe L, Laffer C, Salkoff L, O'Farrell P, Jan YN. Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:233-45. PMID: 6327158.
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    119. O'Farrell P, Ivarie RD. The glucocorticoid domain of response: measurement of pleiotropic cellular responses by two-dimensional gel electrophoresis. Monogr Endocrinol. 1979; 12:189-201. PMID: 226869.
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    120. Gelfand DH, Shepard HM, O'Farrell P, Polisky B. Isolation and characterization of ColE1-derived plasmid copy-number mutant. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5869-73. PMID: 104293; PMCID: PMC393077.
    121. O'Farrell P. The suppression of defective translation by ppGpp and its role in the stringent response. Cell. 1978 Jul; 14(3):545-57. PMID: 357011.
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    122. O'Farrell P, Polisky B, Gelfand DH. Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase. J Bacteriol. 1978 May; 134(2):645-54. PMID: 207672; PMCID: PMC222298.
    123. Ivarie RD, O'Farrell P. The glucocorticoid domain: steroid-mediated changes in the rate of synthesis of rat hepatoma proteins. Cell. 1978 Jan; 13(1):41-55. PMID: 23216.
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    124. O'Farrell PZ, Goodman HM, O'Farrell P. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 1977 Dec; 12(4):1133-41. PMID: 23215.
      View in: PubMed
    125. Steinberg RA, O'Farrell P, Friedrich U, Coffino P. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Cell. 1977 Mar; 10(3):381-91. PMID: 191196.
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    126. O'Farrell PH, O'Farrell P. Two-dimensional polyacrylamide gel electrophoretic fractionation. Methods Cell Biol. 1977; 16:407-20. PMID: 196157.
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    127. O'Farrell P. High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 1975 May 25; 250(10):4007-21. PMID: 236308; PMCID: PMC2874754.
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