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Alden Harken, MD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentSurgery
Address1411 East 31st Street
Oakland CA 94602
Phone510-437-4091
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    Collapse Research 
    Collapse Research Activities and Funding
    Overall Application: Trauma Primes Cells
    NIH/NIGMS P50GM049222Apr 1, 1993 - Aug 31, 2018
    Role: Co-Principal Investigator
    Mechanisms of Post-Injury Organ Failure
    NIH/NIGMS T32GM008315Jul 1, 1991 - Jun 30, 2021
    Role: Co-Principal Investigator
    CYTOKINE ENHANCEMENT OF POSTISCHEMIC CARDIAC FUNCTION
    NIH/NHLBI R01HL044186Jan 1, 1990 - Dec 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Harken A. The case of a chase for the kinase. J Thorac Cardiovasc Surg. 2018 Jan 31. PMID: 29455961.
      View in: PubMed
    2. Harken A. Surgery makes patients happy. J Thorac Cardiovasc Surg. 2018 Mar; 155(3):970-971. PMID: 29103819.
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    3. Harken A. Carpet-bombing the colon is bad. J Thorac Cardiovasc Surg. 2018 Feb; 155(2):659. PMID: 29102212.
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    4. Harken A. The Tin Man finally gets his heart. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):949-950. PMID: 28676182.
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    5. Harken A. The promise of placental power. J Thorac Cardiovasc Surg. 2017 Aug; 154(2):541-542. PMID: 28416332.
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    6. Harken A. It's not about eating. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):989. PMID: 28377121.
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    7. Harken A. Order out of chaos. J Thorac Cardiovasc Surg. 2017 May; 153(5):1085-1086. PMID: 28268007.
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    8. Harken A. Cardiomyocyte psychology. J Thorac Cardiovasc Surg. 2017 Mar; 153(3):596. PMID: 27665223.
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    9. Harken A. Macro or micro: The beat goes on. J Thorac Cardiovasc Surg. 2016 Sep; 152(3):932. PMID: 27318617.
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    10. Harken A. Aortic dissection and DNA repair. J Thorac Cardiovasc Surg. 2015 Nov; 150(5):1301-2. PMID: 26395046.
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    11. Chong V, Imhoff L, Harken A. Socioeconomic status and the assessment of operative risk. Surgery. 2015 Apr; 157(4):605-8. PMID: 25633737.
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    12. Harken A. To block or not to block? That is the question. J Thorac Cardiovasc Surg. 2015 Apr; 149(4):1040-1. PMID: 25659853.
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    13. Harken A. Cardiac cannibalism. J Thorac Cardiovasc Surg. 2014 Sep 28; 148(6):3178-3179. PMID: 25439482.
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    14. Harken A. Heart and soul. J Thorac Cardiovasc Surg. 2014 Nov; 148(5):2380. PMID: 25444201.
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    15. Green A, Markham S, Williams J, Graf J, Morgan A, Brooke M, Harken A. The ladies need more attention. Surgery. 2014 Sep; 156(3):517-8. PMID: 25175502.
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    16. Harken A. How much do we really know about statins and transplant vasculopathy? World J Surg. 2014 Sep; 38(9):2335-6. PMID: 24844656.
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    17. Upadhyaya P, Smith R, Swift UM, Warshaw AL, Harken A. Mentoring for global health missions. Surgery. 2013 Jun; 153(6):866-70. PMID: 23489941.
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    18. Harken A. Joseph Murray as mentor. J Craniofac Surg. 2013 Jan; 24(1):38-40. PMID: 23321868.
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    19. Palmer BJ, Parks NS, Harken A. Surgical trainees like to be trained. Surgery. 2012 Nov; 152(5):805-6. PMID: 23084409.
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    20. Yeung L, Miraflor E, Harken A. Confronting the chronically anticoagulated, acute care surgery patient as we evolve into the post-warfarin era. Surgery. 2013 Mar; 153(3):308-15. PMID: 23122931.
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    21. Zaydfudim V, Sarr MG, Harken A, Warshaw AL. Tumor vs neoplasm: it is not just semantics. Surgery. 2013 Apr; 153(4):603-4. PMID: 22910489.
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    22. Lin C, Sasaki T, Strumwasser A, Harken A. The case against BRCA 1 and 2 testing. Surgery. 2011 Jun; 149(6):731-4. PMID: 21621683.
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    23. Harken T, Harken A. Pregnancy is protective. Surgery. 2011 Feb; 149(2):163. PMID: 21238711.
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    24. Harken A. Edgar J. Poth memorial lecture: the future of general surgery is controlled by surgical megafauna. Am J Surg. 2010 Dec; 200(6):678-80. PMID: 21146001.
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    25. Restivo TE, Mace KA, Harken A, Young DM. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma. 2010 Aug; 69(2):392-8. PMID: 20699749.
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    26. Harken TR, Russell KW, Harken A, Russell RT. Surgical megafauna. Bull Am Coll Surg. 2010 Mar; 95(3):24-8. PMID: 21456404.
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    27. Wielgus J, Sarr MG, Warshaw AL, Harken A. Words, words, words. Surgery. 2010 Jan; 147(1):138-9. PMID: 20082799.
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    28. Bullard MK, Bir N, Kwan R, Cureton E, Knudson P, Harken A. Women rule. Surgery. 2010 Jan; 147(1):134-7. PMID: 20082798.
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    29. Cureton EL, Ereso AQ, Victorino GP, Curran B, Poole DP, Liao M, Harken A, Bhargava A. Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology. 2009 Dec; 150(12):5428-37. PMID: 19819946; PMCID: PMC2795720.
    30. Francis-Goforth KN, Harken A, Saba JD. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. PMID: 19703697; PMCID: PMC2827630.
    31. Palmer BJ, Stams V, Russell TR, Harken A, Britt LD. ACS promotes the six competencies of the accreditation council for graduate medical education. Bull Am Coll Surg. 2009 Jul; 94(7):16-22. PMID: 19718967.
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    32. Harken A. Commentary: Kubler-Ross 5 stages in the recognition of poor surgical resident performance. Surgery. 2009 Jun; 145(6):661-2. PMID: 19486770.
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    33. Cripps MW, Ereso AQ, Sadjadi J, Harken A, Victorino GP. The number of gunshot wounds does not predict injury severity and mortality. Am Surg. 2009 Jan; 75(1):44-7; discussion 48. PMID: 19213396.
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    34. Williams TM, Sadjadi J, Harken A, Victorino GP. The necessity to assess anticoagulation status in elderly injured patients. J Trauma. 2008 Oct; 65(4):772-6; discussion 776-7. PMID: 18849789.
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    35. Liu T, Harken A. Surgical education is safe. J Card Surg. 2008 Jan-Feb; 23(1):6-7. PMID: 18290879.
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    36. Williams TM, Harken A. Statins for surgical patients. Ann Surg. 2008 Jan; 247(1):30-7. PMID: 18156920.
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    37. Baldwin ZK, Spitzer AL, Ng VL, Harken A. Contemporary standards for the diagnosis and treatment of heparin-induced thrombocytopenia (HIT). Surgery. 2008 Mar; 143(3):305-12. PMID: 18291250.
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    38. Backster A, Teo A, Swift M, Polk HC, Harken A. Transforming the surgical "time-out" into a comprehensive "preparatory pause". J Card Surg. 2007 Sep-Oct; 22(5):410-6. PMID: 17803578.
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    39. Kumar AS, Shibru D, Bullard MK, Liu T, Harken A. Case-based multimedia program enhances the maturation of surgical residents regarding the concepts of professionalism. J Surg Educ. 2007 Jul-Aug; 64(4):194-8. PMID: 17706570.
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    40. Roland CL, Harken A, Sarr MG, Barnett CC. ICAM-1 expression determines malignant potential of cancer. Surgery. 2007 Jun; 141(6):705-7. PMID: 17560245.
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    41. Altpeter T, Luckhardt K, Lewis JN, Harken A, Polk HC. Expanded surgical time out: a key to real-time data collection and quality improvement. J Am Coll Surg. 2007 Apr; 204(4):527-32. PMID: 17382210.
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    42. Harken A. Surgical research promotes world peace. Ann Surg. 2007 Apr; 245(4):524-5. PMID: 17414598; PMCID: PMC1877046.
    43. Pavlic LK, Harken A, Sethna D. Transvenous cardioverter-defibrillator placement via a persistent left superior vena cava. J Card Surg. 2007 Mar-Apr; 22(2):152-3. PMID: 17338754.
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    44. Bullard MK, Swift M, Harken A. Genomics and the cardiac surgeon. J Card Surg. 2007 Jan-Feb; 22(1):83-6. PMID: 17239225.
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    45. Tendulkar AP, Harken A. Mechanics of the normal heart. J Card Surg. 2006 Nov-Dec; 21(6):615-20. PMID: 17073971.
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    46. Swift UM, Harken A. Da Vinci's problem. Surgery. 2006 Sep; 140(3):336-7. PMID: 16934590.
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    47. Wan JJ, Mortensen E, Knudson MM, Harken A. Blood doping in the surgical intensive care unit. Surgery. 2006 Jul; 140(1):6-8. PMID: 16857435.
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    48. Harken A. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg. 2006 Jul; 132(1):10-1. PMID: 16798295.
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    49. McGee GE, Warshaw AL, Harken A. Mississippi medical liability reform experience. Surgery. 2006 Apr; 139(4):462-5. PMID: 16627054.
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    50. Swift MB, Altman D, Allison G, Iton A, Kears D, Rose T, Harken A. Osler's advice to "shun politics" is outdated. Surgery. 2006 Apr; 139(4):466-8. PMID: 16627055.
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    51. Pal JD, Victorino GP, Twomey P, Liu TH, Bullard MK, Harken A. Admission serum lactate levels do not predict mortality in the acutely injured patient. J Trauma. 2006 Mar; 60(3):583-7; discussion 587-9. PMID: 16531858.
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    52. Moore EE, Moore FA, Harken A, Johnson JL, Ciesla D, Banerjee A. The two-event construct of postinjury multiple organ failure. Shock. 2005 Dec; 24 Suppl 1:71-4. PMID: 16374376.
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    53. Clarke JH, Cha JY, Walsh MD, Harken A, McCarter MD. Dendritic cells as therapeutic adjuncts in surgical disease. Surgery. 2005 Nov; 138(5):844-50. PMID: 16291384.
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    54. Tendulkar AP, Victorino GP, Chong TJ, Bullard MK, Liu TH, Harken A. Quantification of surgical resident stress "on call". J Am Coll Surg. 2005 Oct; 201(4):560-4. PMID: 16183494.
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    55. Clarke JH, Cha JY, Walsh MD, Gamboni-Robertson F, Banerjee A, Reznikov LL, Dinarello CA, Harken A, McCarter MD. Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. J Am Coll Surg. 2005 Sep; 201(3):418-25. PMID: 16125076.
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    56. Harken A. Hyperbolic hypotheses. Surgery. 2005 Sep; 138(3):404. PMID: 16213886.
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    57. Sahar DE, Yang GP, Longaker MT, Harken A. Surgical application of cDNA microarray technique. Surgery. 2005 Sep; 138(3):399-403. PMID: 16213884.
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    58. Ganim RB, Harken A. Invited commentary: Looking beyond bare survival. Surgery. 2005 Feb; 137(2):178-9. PMID: 15674198.
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    59. Neidlinger NA, Hirvela ER, Skinner RA, Larkin SK, Harken A, Kuypers FA. Postinjury serum secretory phospholipase A2 correlates with hypoxemia and clinical status at 72 hours. J Am Coll Surg. 2005 Feb; 200(2):173-8. PMID: 15664090.
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    60. Barry L, Blair PG, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Kirksey TD, Liscum KR, Morrison R, Sachdeva AK, Svahn DS, Russell TR, Dickey J, Ungerleider RM, Harken A. One year, and counting, after publication of our ACS "Code of Professional Conduct". J Am Coll Surg. 2004 Nov; 199(5):736-40. PMID: 15501114.
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    61. Harken A. Skateboards promote world peace. Surgery. 2004 May; 135(5):471-2. PMID: 15118581.
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    62. Barsness KA, Arcaroli J, Harken A, Abraham E, Banerjee A, Reznikov L, McIntyre RC. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol. 2004 Sep; 287(3):R592-9. PMID: 15072965.
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    63. McCarter MD, Clarke JH, Harken A. Lymphangiogenesis is pivotal to the trials of a successful cancer metastasis. Surgery. 2004 Feb; 135(2):121-4. PMID: 14739845.
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    64. Arya J, Cha JY, Banerjee A, Harken A. RNA silencing in surgical disease. Arch Surg. 2003 Oct; 138(10):1145-7; discussion 1148. PMID: 14557135.
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    65. Gruen RL, Arya J, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Friedman P, Kirksey TD, Kodner IJ, Lewis FR, Liscum KR, Organ CH, Rosenfeld JC, Russell TR, Sachdeva AK, Zook EG, Harken A. Professionalism in surgery. J Am Coll Surg. 2003 Oct; 197(4):605-8. PMID: 14522330.
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    66. Lyons WS, Calkins CM, Moore EE, Bensard DD, Partrick DA, McIntyre RC, Harken A. "Resistance" to the inflammatory response and multiple organ failure in children. J Trauma. 2003 Jul; 55(1):182-4; author reply 183-4. PMID: 12855904.
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    67. Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken A. Diagnostic implications of C-reactive protein. Arch Surg. 2003 Feb; 138(2):220-4. PMID: 12578424.
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    68. Calkins CM, Bensard DD, Moore EE, McIntyre RC, Silliman CC, Biffl W, Harken A, Partrick DA, Offner PJ. The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma. 2002 Dec; 53(6):1058-63. PMID: 12478028.
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    69. Raeburn CD, Zimmerman MA, Arya J, Banerjee A, Harken A. Stem cells and myocardial repair. J Am Coll Surg. 2002 Nov; 195(5):686-93. PMID: 12437260.
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    70. Arya J, Wolford H, Harken A. Evidence-based science: a worthwhile mode of surgical inquiry. Arch Surg. 2002 Nov; 137(11):1301-3. PMID: 12413324.
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    71. Sheppard oR, Moore EE, Ryder J, Harken A, Rezende-Neto JB, Banerjee A, Silliman CC. "Primed" human neutrophils on a standard peripheral blood smear. J Am Coll Surg. 2002 Nov; 195(5):731. PMID: 12437265.
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    72. Raeburn CD, Zimmerman MA, Arya J, Barsness K, Harken A. Ischemic preconditioning: fact or fantasy? J Card Surg. 2002 Nov-Dec; 17(6):536-42. PMID: 12643465.
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    73. Harken A. Invited commentary: how do we recruit bright and selflessly capable students into the gratifying profession of surgery? Surgery. 2002 Nov; 132(5):803-4. PMID: 12464863.
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    74. Zimmerman MA, Selzman CH, Reznikov LL, Miller SA, Raeburn CD, Emmick J, Meng X, Harken A. Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R505-12. PMID: 12121864.
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    75. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken A, Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R477-86. PMID: 12121861.
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    76. Selzman CH, Miller SA, Zimmerman MA, Gamboni-Robertson F, Harken A, Banerjee A. Monocyte chemotactic protein-1 directly induces human vascular smooth muscle proliferation. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1455-61. PMID: 12234797.
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    77. Meng X, Harken A. The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock. 2002 May; 17(5):345-53. PMID: 12022752.
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    78. Raeburn CD, Calkins CM, Zimmerman MA, Arya J, Barsness KA, Harken A. Toll-like receptors and surgical disease. Surgery. 2002 May; 131(5):477-83. PMID: 12019398.
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    79. Rabaglia JL, Gonzalez R, Moore EE, Harken A. Pooled human albumin primes neutrophils. J Card Surg. 2002 May-Jun; 17(3):209-13. PMID: 12489905.
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    80. Raeburn CD, Sheppard F, Barsness KA, Arya J, Harken A. Cytokines for surgeons. Am J Surg. 2002 Mar; 183(3):268-73. PMID: 11943124.
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    81. Selzman CH, Turner AS, Gaynor JS, Miller SA, Monnet E, Harken A. Inhibition of intimal hyperplasia using the selective estrogen receptor modulator raloxifene. Arch Surg. 2002 Mar; 137(3):333-6. PMID: 11888462.
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    82. Meldrum KK, Meldrum DR, Meng X, Ao L, Harken A. TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H540-6. PMID: 11788401.
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    83. Cothren C, Ferucci P, Harken A, Veve R, Finlayson CA, Johnson JL. Urachal carcinoma: key points for the general surgeon. Am Surg. 2002 Feb; 68(2):201-3. PMID: 11842971.
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    84. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken A, Meng X. Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock. 2002 Feb; 17(2):114-9. PMID: 11837786.
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