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Alden Harken, MD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentSurgery
Address1411 East 31st Street
Oakland CA 94602
Phone510-437-4091
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    Collapse Research 
    Collapse Research Activities and Funding
    Overall Application: Trauma Primes Cells
    NIH/NIGMS P50GM049222Apr 1, 1993 - Aug 31, 2018
    Role: Co-Principal Investigator
    Mechanisms of Post-Injury Organ Failure
    NIH/NIGMS T32GM008315Jul 1, 1991 - Jun 30, 2021
    Role: Co-Principal Investigator
    CYTOKINE ENHANCEMENT OF POSTISCHEMIC CARDIAC FUNCTION
    NIH/NHLBI R01HL044186Jan 1, 1990 - Dec 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harken AH. I got rhythm. J Thorac Cardiovasc Surg. 2018 Aug 11. PMID: 30177253.
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    2. Harken AH. The tranquil consciousness of effortless superiority. J Thorac Cardiovasc Surg. 2018 Jul 19. PMID: 30174125.
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    3. Macke RA, Ghanta R, Starnes S, Harken AH. So, you are looking for a job: Pearls for a successful first cardiothoracic job search. J Thorac Cardiovasc Surg. 2018 Jun 06. PMID: 30005888.
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    4. Harken AH. The case of a chase for the kinase. J Thorac Cardiovasc Surg. 2018 Jan 31. PMID: 29455961.
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    5. Harken AH. Surgery makes patients happy. J Thorac Cardiovasc Surg. 2018 Mar; 155(3):970-971. PMID: 29103819.
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    6. Harken AH. Carpet-bombing the colon is bad. J Thorac Cardiovasc Surg. 2018 Feb; 155(2):659. PMID: 29102212.
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    7. Harken AH. The Tin Man finally gets his heart. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):949-950. PMID: 28676182.
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    8. Harken AH. The promise of placental power. J Thorac Cardiovasc Surg. 2017 Aug; 154(2):541-542. PMID: 28416332.
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    9. Harken AH. It's not about eating. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):989. PMID: 28377121.
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    10. Harken AH. Order out of chaos. J Thorac Cardiovasc Surg. 2017 May; 153(5):1085-1086. PMID: 28268007.
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    11. Harken AH. Cardiomyocyte psychology. J Thorac Cardiovasc Surg. 2017 Mar; 153(3):596. PMID: 27665223.
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    12. Harken AH. Macro or micro: The beat goes on. J Thorac Cardiovasc Surg. 2016 Sep; 152(3):932. PMID: 27318617.
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    13. Harken AH. Aortic dissection and DNA repair. J Thorac Cardiovasc Surg. 2015 Nov; 150(5):1301-2. PMID: 26395046.
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    14. Chong V, Imhoff L, Harken A. Socioeconomic status and the assessment of operative risk. Surgery. 2015 Apr; 157(4):605-8. PMID: 25633737.
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    15. Harken AH. To block or not to block? That is the question. J Thorac Cardiovasc Surg. 2015 Apr; 149(4):1040-1. PMID: 25659853.
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    16. Harken AH. Cardiac cannibalism. J Thorac Cardiovasc Surg. 2014 Sep 28; 148(6):3178-3179. PMID: 25439482.
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    17. Harken AH. Heart and soul. J Thorac Cardiovasc Surg. 2014 Nov; 148(5):2380. PMID: 25444201.
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    18. Green A, Markham S, Williams J, Graf J, Morgan A, Brooke M, Harken AH. The ladies need more attention. Surgery. 2014 Sep; 156(3):517-8. PMID: 25175502.
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    19. Harken AH. How much do we really know about statins and transplant vasculopathy? World J Surg. 2014 Sep; 38(9):2335-6. PMID: 24844656.
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    20. Upadhyaya P, Smith R, Swift UM, Warshaw AL, Harken AH. Mentoring for global health missions. Surgery. 2013 Jun; 153(6):866-70. PMID: 23489941.
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    21. Harken AH. Joseph Murray as mentor. J Craniofac Surg. 2013 Jan; 24(1):38-40. PMID: 23321868.
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    22. Palmer BJ, Parks NS, Harken AH. Surgical trainees like to be trained. Surgery. 2012 Nov; 152(5):805-6. PMID: 23084409.
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    23. Yeung L, Miraflor E, Harken A. Confronting the chronically anticoagulated, acute care surgery patient as we evolve into the post-warfarin era. Surgery. 2013 Mar; 153(3):308-15. PMID: 23122931.
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    24. Zaydfudim V, Sarr MG, Harken AH, Warshaw AL. Tumor vs neoplasm: it is not just semantics. Surgery. 2013 Apr; 153(4):603-4. PMID: 22910489.
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    25. Lin C, Sasaki T, Strumwasser A, Harken A. The case against BRCA 1 and 2 testing. Surgery. 2011 Jun; 149(6):731-4. PMID: 21621683.
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    26. Harken T, Harken A. Pregnancy is protective. Surgery. 2011 Feb; 149(2):163. PMID: 21238711.
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    27. Harken AH. Edgar J. Poth memorial lecture: the future of general surgery is controlled by surgical megafauna. Am J Surg. 2010 Dec; 200(6):678-80. PMID: 21146001.
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    28. Restivo TE, Mace KA, Harken AH, Young DM. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma. 2010 Aug; 69(2):392-8. PMID: 20699749.
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    29. Harken TR, Russell KW, Harken A, Russell RT. Surgical megafauna. Bull Am Coll Surg. 2010 Mar; 95(3):24-8. PMID: 21456404.
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    30. Wielgus J, Sarr MG, Warshaw AL, Harken AH. Words, words, words. Surgery. 2010 Jan; 147(1):138-9. PMID: 20082799.
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    31. Bullard MK, Bir N, Kwan R, Cureton E, Knudson P, Harken A. Women rule. Surgery. 2010 Jan; 147(1):134-7. PMID: 20082798.
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    32. Cureton EL, Ereso AQ, Victorino GP, Curran B, Poole DP, Liao M, Harken AH, Bhargava A. Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology. 2009 Dec; 150(12):5428-37. PMID: 19819946; PMCID: PMC2795720.
    33. Francis-Goforth KN, Harken AH, Saba JD. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. PMID: 19703697; PMCID: PMC2827630.
    34. Palmer BJ, Stams V, Russell TR, Harken AH, Britt LD. ACS promotes the six competencies of the accreditation council for graduate medical education. Bull Am Coll Surg. 2009 Jul; 94(7):16-22. PMID: 19718967.
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    35. Harken AH. Commentary: Kubler-Ross 5 stages in the recognition of poor surgical resident performance. Surgery. 2009 Jun; 145(6):661-2. PMID: 19486770.
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    36. Cripps MW, Ereso AQ, Sadjadi J, Harken AH, Victorino GP. The number of gunshot wounds does not predict injury severity and mortality. Am Surg. 2009 Jan; 75(1):44-7; discussion 48. PMID: 19213396.
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    37. Williams TM, Sadjadi J, Harken AH, Victorino GP. The necessity to assess anticoagulation status in elderly injured patients. J Trauma. 2008 Oct; 65(4):772-6; discussion 776-7. PMID: 18849789.
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    38. Liu T, Harken AH. Surgical education is safe. J Card Surg. 2008 Jan-Feb; 23(1):6-7. PMID: 18290879.
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    39. Williams TM, Harken AH. Statins for surgical patients. Ann Surg. 2008 Jan; 247(1):30-7. PMID: 18156920.
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    40. Baldwin ZK, Spitzer AL, Ng VL, Harken AH. Contemporary standards for the diagnosis and treatment of heparin-induced thrombocytopenia (HIT). Surgery. 2008 Mar; 143(3):305-12. PMID: 18291250.
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    41. Backster A, Teo A, Swift M, Polk HC, Harken AH. Transforming the surgical "time-out" into a comprehensive "preparatory pause". J Card Surg. 2007 Sep-Oct; 22(5):410-6. PMID: 17803578.
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    42. Kumar AS, Shibru D, Bullard MK, Liu T, Harken AH. Case-based multimedia program enhances the maturation of surgical residents regarding the concepts of professionalism. J Surg Educ. 2007 Jul-Aug; 64(4):194-8. PMID: 17706570.
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    43. Roland CL, Harken AH, Sarr MG, Barnett CC. ICAM-1 expression determines malignant potential of cancer. Surgery. 2007 Jun; 141(6):705-7. PMID: 17560245.
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    44. Altpeter T, Luckhardt K, Lewis JN, Harken AH, Polk HC. Expanded surgical time out: a key to real-time data collection and quality improvement. J Am Coll Surg. 2007 Apr; 204(4):527-32. PMID: 17382210.
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    45. Harken AH. Surgical research promotes world peace. Ann Surg. 2007 Apr; 245(4):524-5. PMID: 17414598; PMCID: PMC1877046.
    46. Pavlic LK, Harken AH, Sethna D. Transvenous cardioverter-defibrillator placement via a persistent left superior vena cava. J Card Surg. 2007 Mar-Apr; 22(2):152-3. PMID: 17338754.
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    47. Bullard MK, Swift M, Harken A. Genomics and the cardiac surgeon. J Card Surg. 2007 Jan-Feb; 22(1):83-6. PMID: 17239225.
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    48. Tendulkar AP, Harken AH. Mechanics of the normal heart. J Card Surg. 2006 Nov-Dec; 21(6):615-20. PMID: 17073971.
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    49. Swift UM, Harken AH. Da Vinci's problem. Surgery. 2006 Sep; 140(3):336-7. PMID: 16934590.
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    50. Wan JJ, Mortensen E, Knudson MM, Harken AH. Blood doping in the surgical intensive care unit. Surgery. 2006 Jul; 140(1):6-8. PMID: 16857435.
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    51. Harken AH. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg. 2006 Jul; 132(1):10-1. PMID: 16798295.
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    52. McGee GE, Warshaw AL, Harken AH. Mississippi medical liability reform experience. Surgery. 2006 Apr; 139(4):462-5. PMID: 16627054.
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    53. Swift MB, Altman D, Allison G, Iton A, Kears D, Rose T, Harken AH. Osler's advice to "shun politics" is outdated. Surgery. 2006 Apr; 139(4):466-8. PMID: 16627055.
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    54. Pal JD, Victorino GP, Twomey P, Liu TH, Bullard MK, Harken AH. Admission serum lactate levels do not predict mortality in the acutely injured patient. J Trauma. 2006 Mar; 60(3):583-7; discussion 587-9. PMID: 16531858.
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    55. Moore EE, Moore FA, Harken AH, Johnson JL, Ciesla D, Banerjee A. The two-event construct of postinjury multiple organ failure. Shock. 2005 Dec; 24 Suppl 1:71-4. PMID: 16374376.
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    56. Clarke JH, Cha JY, Walsh MD, Harken AH, McCarter MD. Dendritic cells as therapeutic adjuncts in surgical disease. Surgery. 2005 Nov; 138(5):844-50. PMID: 16291384.
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    57. Tendulkar AP, Victorino GP, Chong TJ, Bullard MK, Liu TH, Harken AH. Quantification of surgical resident stress "on call". J Am Coll Surg. 2005 Oct; 201(4):560-4. PMID: 16183494.
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    58. Clarke JH, Cha JY, Walsh MD, Gamboni-Robertson F, Banerjee A, Reznikov LL, Dinarello CA, Harken AH, McCarter MD. Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. J Am Coll Surg. 2005 Sep; 201(3):418-25. PMID: 16125076.
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    59. Harken AH. Hyperbolic hypotheses. Surgery. 2005 Sep; 138(3):404. PMID: 16213886.
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    60. Sahar DE, Yang GP, Longaker MT, Harken AH. Surgical application of cDNA microarray technique. Surgery. 2005 Sep; 138(3):399-403. PMID: 16213884.
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    61. Ganim RB, Harken AH. Invited commentary: Looking beyond bare survival. Surgery. 2005 Feb; 137(2):178-9. PMID: 15674198.
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    62. Neidlinger NA, Hirvela ER, Skinner RA, Larkin SK, Harken AH, Kuypers FA. Postinjury serum secretory phospholipase A2 correlates with hypoxemia and clinical status at 72 hours. J Am Coll Surg. 2005 Feb; 200(2):173-8. PMID: 15664090.
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    63. Barry L, Blair PG, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Kirksey TD, Liscum KR, Morrison R, Sachdeva AK, Svahn DS, Russell TR, Dickey J, Ungerleider RM, Harken AH. One year, and counting, after publication of our ACS "Code of Professional Conduct". J Am Coll Surg. 2004 Nov; 199(5):736-40. PMID: 15501114.
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    64. Harken AH. Skateboards promote world peace. Surgery. 2004 May; 135(5):471-2. PMID: 15118581.
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    65. Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L, McIntyre RC. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol. 2004 Sep; 287(3):R592-9. PMID: 15072965.
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    66. McCarter MD, Clarke JH, Harken AH. Lymphangiogenesis is pivotal to the trials of a successful cancer metastasis. Surgery. 2004 Feb; 135(2):121-4. PMID: 14739845.
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    67. Arya J, Cha JY, Banerjee A, Harken AH. RNA silencing in surgical disease. Arch Surg. 2003 Oct; 138(10):1145-7; discussion 1148. PMID: 14557135.
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    68. Gruen RL, Arya J, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Friedman P, Kirksey TD, Kodner IJ, Lewis FR, Liscum KR, Organ CH, Rosenfeld JC, Russell TR, Sachdeva AK, Zook EG, Harken AH. Professionalism in surgery. J Am Coll Surg. 2003 Oct; 197(4):605-8. PMID: 14522330.
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    69. Lyons WS, Calkins CM, Moore EE, Bensard DD, Partrick DA, McIntyre RC, Harken AH. "Resistance" to the inflammatory response and multiple organ failure in children. J Trauma. 2003 Jul; 55(1):182-4; author reply 183-4. PMID: 12855904.
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    70. Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken AH. Diagnostic implications of C-reactive protein. Arch Surg. 2003 Feb; 138(2):220-4. PMID: 12578424.
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    71. Calkins CM, Bensard DD, Moore EE, McIntyre RC, Silliman CC, Biffl W, Harken AH, Partrick DA, Offner PJ. The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma. 2002 Dec; 53(6):1058-63. PMID: 12478028.
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    72. Raeburn CD, Zimmerman MA, Arya J, Banerjee A, Harken AH. Stem cells and myocardial repair. J Am Coll Surg. 2002 Nov; 195(5):686-93. PMID: 12437260.
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    73. Arya J, Wolford H, Harken AH. Evidence-based science: a worthwhile mode of surgical inquiry. Arch Surg. 2002 Nov; 137(11):1301-3. PMID: 12413324.
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    74. Sheppard oR, Moore EE, Ryder J, Harken AH, Rezende-Neto JB, Banerjee A, Silliman CC. "Primed" human neutrophils on a standard peripheral blood smear. J Am Coll Surg. 2002 Nov; 195(5):731. PMID: 12437265.
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    75. Raeburn CD, Zimmerman MA, Arya J, Barsness K, Harken AH. Ischemic preconditioning: fact or fantasy? J Card Surg. 2002 Nov-Dec; 17(6):536-42. PMID: 12643465.
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    76. Harken AH. Invited commentary: how do we recruit bright and selflessly capable students into the gratifying profession of surgery? Surgery. 2002 Nov; 132(5):803-4. PMID: 12464863.
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    77. Zimmerman MA, Selzman CH, Reznikov LL, Miller SA, Raeburn CD, Emmick J, Meng X, Harken AH. Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R505-12. PMID: 12121864.
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    78. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R477-86. PMID: 12121861.
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    79. Selzman CH, Miller SA, Zimmerman MA, Gamboni-Robertson F, Harken AH, Banerjee A. Monocyte chemotactic protein-1 directly induces human vascular smooth muscle proliferation. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1455-61. PMID: 12234797.
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    80. Meng X, Harken AH. The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock. 2002 May; 17(5):345-53. PMID: 12022752.
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    81. Raeburn CD, Calkins CM, Zimmerman MA, Arya J, Barsness KA, Harken AH. Toll-like receptors and surgical disease. Surgery. 2002 May; 131(5):477-83. PMID: 12019398.
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    82. Rabaglia JL, Gonzalez R, Moore EE, Harken AH. Pooled human albumin primes neutrophils. J Card Surg. 2002 May-Jun; 17(3):209-13. PMID: 12489905.
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    83. Raeburn CD, Sheppard F, Barsness KA, Arya J, Harken AH. Cytokines for surgeons. Am J Surg. 2002 Mar; 183(3):268-73. PMID: 11943124.
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    84. Selzman CH, Turner AS, Gaynor JS, Miller SA, Monnet E, Harken AH. Inhibition of intimal hyperplasia using the selective estrogen receptor modulator raloxifene. Arch Surg. 2002 Mar; 137(3):333-6. PMID: 11888462.
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    85. Meldrum KK, Meldrum DR, Meng X, Ao L, Harken AH. TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H540-6. PMID: 11788401.
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    86. Cothren C, Ferucci P, Harken AH, Veve R, Finlayson CA, Johnson JL. Urachal carcinoma: key points for the general surgeon. Am Surg. 2002 Feb; 68(2):201-3. PMID: 11842971.
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    87. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken AH, Meng X. Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock. 2002 Feb; 17(2):114-9. PMID: 11837786.
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