I am a computational physician-scientist situated at the intersection of anesthesiology and genomics. A core and longstanding research focus of mine is investigating potential translations of CRISPR technology into medicine, as a direct agent, by leveraging individual genome level designs of CRISPR gRNAs against a patient's disease. To this end my work has shown the ability of CRISPR to enable the cancer-specific targeting and destruction of a patient derived glioblastoma multiforme (GBM) in a murine model, the ability to generate individual level CRISPR gRNA libraries in any CRISPR system, in any genome, and with an arbitrary level of specificity, and finally the ability to correct for off-target non-specificity effects in CRISPR libraries. An co-equal research focus I have relates to the role of non-coding genomics, specifically transposable elements, in the pathogenesis and disease maintenance of sepsis and critical illness. Transposable elements compose approximately 50% of the human genome and their importance in disease and aging is being increasingly appreciated. The role transposable elements play in disease states of extreme physiologic stress is of deep interest to me. My research is supported by public, private, and departmental grants.

I am a board-certified anesthesiologist in general practice in the UCSF operating rooms. I have an undergraduate degree in computational biology, a Ph.D in computer science/bioinformatics, and a medical degree all from Cornell University. I completed my residency in anesthesiology at UCSF as part of the AIRR Program (formally Research Scholars Program). I completed my postdoc jointly at UCSF and NCI/NIH.