Judith Hellman, MD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address521 Parnassus Avenue, #4503
San Francisco CA 94117
Phone415-476-5950
ORCID ORCID Icon0000-0003-2278-6625 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia UniversityM.D.1989School of Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    My research program is focused on basic and translational research on sepsis and other forms of inflammation-driven acute organ failure ("Inflammatory Critical Illness"). Sepsis and multiple organ failure are leading causes of death in the Intensive Care Unit. These processes result from a complex inflammatory response that is initiated through the innate immune system by interactions between host cells and microbes or endogenous host factors that are released during injury or cell death. The family of Toll-like receptors (TLRs) recognize different microbial components and endogenous host factors, and are critical in initiating inflammatory responses to infection. The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure.

    Major Ongoing Projects:
    1. The role of cell-specific extracellular signal-regulated kinases (ERK1/2 and ERK5) in sepsis and inflammatory critical illness. We reported that extracellular signal-regulated kinase 5 (ERK5) mediates the TLR2-dependent activation of human endothelial cells and monocytes (Wilhelmsen et al, JBC 2012). Subsequently we found that ERK5 promotes endothelial activation by a broad range of microbial and host agonists, including LPS (TLR4), IL-1β (IL1R), and TNFα (TNFR) (Wilhelmsen et al, Science Signaling 2015). Furthermore, we observed that treatment with ERK5 inhibitor reduces inflammation, coagulopathy, and mortality in LPS-treated mice, but conversely increases mortality and bacteremia in a cecal ligation and puncture model of sepsis. Finally, we made the intriguing observation in vitro that ERK1/2 activation reduces endothelial inflammation induced by LPS and TNFα, in contrast to its role in promoting leukocyte inflammation. We are now further exploring these observations, testing the basic hypotheses that ERK1/2 and ERK5 regulate TLR-dependent and TLR-independent activation of endothelial inflammatory pathways and contribute to endothelial dysfunction in septic shock and organ failure.
    2. The immunomodulatory role of the endocannabinoid system in inflammatory activation of endothelial cells and leukocytes: We recently discovered that the endocannabinoid N-arachidonoyl dopamine (NADA) can negatively regulate endothelial cell activation by a variety of inflammatory agonists. We hypothesize that the endothelial endocannabinoid system may represent a novel regulatory system to therapeutically manipulate in order to ameliorate the manifestations of a variety of inflammatory disorders, including sepsis. We plan to pursue these studies further by identifying other endocannabinoids that regulate EC inflammation, and determining the mechanism by which NADA exerts its effects in ECs. We will also investigate the role of NADA, and the other components of the endocannabinoid system, in vivo using mouse models of infectious and non-infectious inflammation.
    3. The role of TLR2 in bacterial sepsis and organ injury: My lab has been investigating the bacterial lipoproteins in the context of sepsis for over a decade. In our early studies we found that bacterial lipoprotein TLR2 agonists are shed by bacteria into human serum in vitro and into the blood of septic mice and rats in vivo. We have characterized the effects of bacterial lipoproteins on monocytes, macrophages, and endothelial cells, and have done extensive work on the effects of TLR2 activation on coagulation and permeability in vitro and in vivo. We have recently found that TLR2 participates, in a complex fashion, in Staph aureus invasion of organs in a bacteremia model. We are continuing to explore TLR2 pathways in gram-positive and gram-negative sepsis. The goals are to further delineate the downstream pathways leading to coagulopathy and organ failure, and identify potential therapeutic targets to mitigate these deleterious outcomes without negatively impacting bacterial clearance.
    4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. We have found TLR2-dependent activation of endothelial inflammatory pathways, as well as pathways involved in coagulopathy and vascular leak in vitro and in vivo. Thus TLR2 pathways may be important in sepsis-induced coagulopathy and vascular leak. We have defined the roles of several MAPKs (p38, JNK, ERK1/2, ERK5) and of NF-κB in TLR2-dependent signaling to inflammation, and have newly identified ERK5 as a key mediator of TLR2-dependent signaling in endothelial cells and human monocytes. We are continuing to explore the role of these TLR2 signaling intermediaries in the development of coagulopathy and vascular leak in vitro.
    5. The effects of TLR2 activation on coagulation in vivo: We recently found that challenge with bacterial lipopeptides or Staph aureus bacteria TLR2-dependently modulates plasma levels of coagulation pathway factors and coagulation times, and that TLR2 activation increases fibrin deposition in the lungs of mice. We are exploring the mechanisms and functional consequences of these effects, and will expand studies to look at different aspects of coagulation in vivo.
    6. The role of microbial components and endothelial cells in sepsis-induced endothelial and organ dysfunction: We previously found that activation of TLR2 has physiological effects on the lung, including reduced blood arterial blood oxygenation and impaired lung vasoconstrictive responses to alveolar hypoxia. In the future we will further explore the functional significance of activation of TLR2 and other TLRs, in particular TLR4 and TLR9, in sepsis-induced organ failure.
    7. Cellular and molecular mechanisms of lung ischemia-reperfusion injury.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuro-immune mechanisms of minor cannabinoids in inflammatory and neuropathic pain
    NIH R01AT010757Sep 15, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Acyl-dopamines, the transient receptor potential vanilloid 1 (TRPV1) and the endocannabinoid systems in acute inflammation and sepsis
    NIH R01GM132379Sep 1, 2019 - Aug 31, 2020
    Role: Principal Investigator
    TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    NIH R01AI058106Dec 1, 2003 - May 31, 2012
    Role: Principal Investigator
    BACTERIAL SURFACE PROTEINS: POTENTIAL TARGETS FOR SEPSIS
    NIH K08AI001722Jun 1, 2000 - May 31, 2005
    Role: Principal Investigator
    Comprehensive Anesthesia Research Training
    NIH T32GM008440Jul 1, 1995 - Jun 30, 2022
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neonatal Cannabidiol Exposure Impairs Spatial Memory and Disrupts Neuronal Dendritic Morphology in Young Adult Rats. Cannabis Cannabinoid Res. 2024 Sep 10. Wadhwa M, Chinn GA, Sasaki Russell JM, Hellman J, Sall JW. PMID: 39253840.
      View in: PubMed   Mentions:    Fields:    
    2. Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo. Front Med (Lausanne). 2024; 11:1412891. Bokoch MP, Xu F, Govindaraju K, Lloyd E, Tsutsui K, Kothari RP, Adelmann D, Joffre J, Hellman J. PMID: 39021821; PMCID: PMC11252006.
      View in: PubMed   Mentions:
    3. Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s. J Nat Prod. 2024 04 26; 87(4):639-651. Roy P, Maturano J, Hasdemir H, Lopez A, Xu F, Hellman J, Tajkhorshid E, Sarlah D, Das A. PMID: 38477310; PMCID: PMC11061835.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Surviving Sepsis Campaign Research Priorities 2023. Crit Care Med. 2024 02 01; 52(2):268-296. De Backer D, Deutschman CS, Hellman J, Myatra SN, Ostermann M, Prescott HC, Talmor D, Antonelli M, Pontes Azevedo LC, Bauer SR, Kissoon N, Loeches IM, Nunnally M, Tissieres P, Vieillard-Baron A, Coopersmith CM, Surviving Sepsis Campaign Research Committee. PMID: 38240508.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. medRxiv. 2023 Nov 30. Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS. PMID: 38076828; PMCID: PMC10705660.
      View in: PubMed   Mentions:
    6. Abstract 14589: Impairment of Endothelial Function by Chronic Cannabis Use: An Interim Analysis of the CANDIDE Study. Circulation. 2023 Nov 7; 148(Suppl_1):a14589-a14589. Mohammadi ML, Navabzadeh NM, Han HD, Reagan RE, Naughton NJ, Zhou ZL, Almeida AR, Park PK, Uyemura UK, Goyal GN, Rao RP, Hellman HJ, Cheng CJ, Marcus MG, Springer SM. .
      View in: Publisher Site   Mentions:
    7. The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats. Cannabis Cannabinoid Res. 2024 Oct; 9(5):e1443-e1451. Soni I, Chinn GA, Halifax JC, Hellman J, Lynch KL, Sall JW. PMID: 37852006.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Chapter 2 The endocannabinoid system, immunomodulation, and LPS-induced inflammation. Neurobiology and Physiology of the Endocannabinoid System. 2023 Jan 1; 17-34. Lloyd LE, Nguyen NN, Hellman HJ. .
      View in: Publisher Site   Mentions:
    9. Reply to Khatun et al. Am J Respir Crit Care Med. 2022 Nov 01; 206(9):1179-1180. Joffre J, Matthay MA, Hellman J. PMID: 35839475; PMCID: PMC9704822.
      View in: PubMed   Mentions:    Fields:    
    10. Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels. Arterioscler Thromb Vasc Biol. 2022 11; 42(11):1333-1350. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML. PMID: 36288290; PMCID: PMC9625085.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    11. COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Am J Respir Crit Care Med. 2022 10 15; 206(8):961-972. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group. PMID: 35649173; PMCID: PMC9801996.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    12. Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive. Biochemistry. 2022 11 01; 61(21):2398-2408. Roy P, Dennis DG, Eschbach MD, Anand SD, Xu F, Maturano J, Hellman J, Sarlah D, Das A. PMID: 36223199; PMCID: PMC10337483.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    13. A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery. J Am Geriatr Soc. 2023 Jan; 71(1):227-234. Barreto Chang OL, Whitlock EL, Arias AD, Tsoy E, Allen IE, Hellman J, Bickler PE, Miller B, Possin KL. PMID: 36125032; PMCID: PMC9870968.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery. J Vis Exp. 2022 09 09; (187). Liao WI, Maruyama D, Kianian F, Tat C, Tian X, Hellman J, Dodd-O JM, Prakash A. PMID: 36155626; PMCID: PMC9752345.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. J Neuroinflammation. 2022 May 24; 19(1):118. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J. PMID: 35610647; PMCID: PMC9131699.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Triggering toxicity: How antibiotics can enhance the release of outer membrane vesicles from Escherichia coli during sepsis. The FASEB Journal. 2022 May 13; 36(S1). Michel ML, Konovalova KA, Hellman HJ, Gaborski GT. .
      View in: Publisher Site   Mentions:
    17. Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122]. Bone. 2022 May; 158:116325. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. PMID: 35241401.
      View in: PubMed   Mentions:    Fields:    
    18. Abstract 11496: Increased Pulmonary Microvascular Endothelial Permeability by E-Cigarette Aerosol: The Pathway from Lung to Peripheral Blood Vessels. Circulation. 2021 Nov 16; 144(Suppl_1):a11496-a11496. Mohammadi ML, Han HD, Fang FX, Xu XF, Derakhshandeh DR, Hellman HJ, Gotts GJ, Springer SM. .
      View in: Publisher Site   Mentions:
    19. Abstract 9929: Inhibition of Receptor for Advanced Glycation End Products (RAGE) Reduces E-Cigarette-Induced Increase in Endothelial Permeability. Circulation. 2021 Nov 16; 144(Suppl_1):a9929-a9929. Han HD, Xu XF, Derakhshandeh DR, Huang HA, Whitlatch WA, Keith KR, Hamburg HN, Ganz GP, Hellman HJ, Schick SS, Springer SM, Mohammadi ML. .
      View in: Publisher Site   Mentions:
    20. Isolation of Primary Mouse Lung Endothelial Cells. J Vis Exp. 2021 11 10; (177). Wong E, Nguyen N, Hellman J. PMID: 34842233; PMCID: PMC11101010.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Crit Care Explor. 2021 Sep; 3(9):e0511. Martin-Loeches I, Nunnally ME, Hellman J, Lat I, Martin GS, Jog S, Kesecioglu J, De Backer D, Coopersmith CM. PMID: 34514420; PMCID: PMC8425836.
      View in: PubMed   Mentions: 6  
    22. ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages. Bone. 2021 12; 153:116129. Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. PMID: 34311122; PMCID: PMC8803261.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Antioxid Redox Signal. 2021 11 20; 35(15):1291-1307. Joffre J, Hellman J. PMID: 33637016.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    24. The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness. Crit Care Med. 2021 04 01; 49(4):598-622. Coopersmith CM, Antonelli M, Bauer SR, Deutschman CS, Evans LE, Ferrer R, Hellman J, Jog S, Kesecioglu J, Kissoon N, Martin-Loeches I, Nunnally ME, Prescott HC, Rhodes A, Talmor D, Tissieres P, De Backer D. PMID: 33591008.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    25. Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 03 01; 49(3):e315-e326. Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. PMID: 33481407; PMCID: PMC7892263.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Shock. 2021 03 01; 55(3):349-356. Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J. PMID: 32826812; PMCID: PMC8139579.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. Int J Antimicrob Agents. 2020 Dec; 56(6):106163. Michel LV, Gallardo L, Konovalova A, Bauer M, Jackson N, Zavorin M, McNamara C, Pierce J, Cheng S, Snyder E, Hellman J, Pichichero ME. PMID: 32941946.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities. Crit Care Med. 2020 08; 48(8):1217-1232. Deutschman CS, Hellman J, Ferrer Roca R, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign. PMID: 32697495; PMCID: PMC7365680.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020 08 01; 202(3):361-370. Joffre J, Hellman J, Ince C, Ait-Oufella H. PMID: 32101446.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansAnimalsCells
    30. The surviving sepsis campaign: basic/translational science research priorities. Intensive Care Med Exp. 2020 Jul 17; 8(1):31. Deutschman CS, Hellman J, Roca RF, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign. PMID: 32676795; PMCID: PMC7365694.
      View in: PubMed   Mentions: 6  
    31. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 06 15; 204(12):3339-3350. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. PMID: 32385136; PMCID: PMC7276941.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Front Microbiol. 2019; 10:159. Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. PMID: 30891007; PMCID: PMC6413706.
      View in: PubMed   Mentions: 35  
    33. Premise for Standardized Sepsis Models. Shock. 2019 01; 51(1):4-9. Remick DG, Ayala A, Chaudry IH, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski MF. PMID: 29877959; PMCID: PMC6281773.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    34. Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Shock. 2019 01; 51(1):33-43. Hellman J, Bahrami S, Boros M, Chaudry IH, Fritsch G, Gozdzik W, Inoue S, Radermacher P, Singer M, Osuchowski MF, Huber-Lang M. PMID: 29923896.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    35. NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018 11 15; 3(22). Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. PMID: 30429363; PMCID: PMC6302947.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    36. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock. 2018 10; 50(4):377-380. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. PMID: 30106875; PMCID: PMC6133201.
      View in: PubMed   Mentions: 99     Fields:    Translation:Animals
    37. Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp. 2018 Aug 14; 6(1):26. Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. PMID: 30112605; PMCID: PMC6093828.
      View in: PubMed   Mentions: 42  
    38. Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock. Crit Care Med. 2018 08; 46(8):1334-1356. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. PMID: 29957716.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    39. Surviving sepsis campaign: research priorities for sepsis and septic shock. Intensive Care Med. 2018 Sep; 44(9):1400-1426. Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. PMID: 29971592; PMCID: PMC7095388.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    40. Detecting Released Peptidoglycan Associated Lipoprotein (Pal) from Escherichia coli. The FASEB Journal. 2018 Apr 1; 32:526.4-526.4. Snyder SE, Zavorin ZM, Farquaharson FK, Panullo PN, Pichichero PM, Hellman HJ, Michel ML. .
      View in: Publisher Site   Mentions:
    41. Probing the Two Orientations of Pal in Vesiculating E. coli. The FASEB Journal. 2018 Apr 1; 32:671.4-671.4. Pannullo PN, Zavorin ZM, D'Arcy DB, Farquharson FK, Kaur KR, Surendran SN, Pichichero PM, Hellman HJ, Michel ML. .
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    42. NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Front Immunol. 2017; 8:1337. Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A. PMID: 29163464; PMCID: PMC5671513.
      View in: PubMed   Mentions: 15     Fields:    
    43. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. PMID: 28701511; PMCID: PMC5544930.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    44. 20. Critical Care Medicine. 2016 Dec 1; 44(12):91. Lawton LS, Wilhelmsen WK, Xu XF, Tran TA, Wong WE, Hellman HJ. .
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    45. Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5. Guan Z, Hellman J, Schumacher M. PMID: 27781082; PMCID: PMC5054801.
      View in: PubMed   Mentions: 13     Fields:    
    46. Potentiation and tolerance of toll-like receptor priming in human endothelial cells. Transl Res. 2017 02; 180:53-67.e4. Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ. PMID: 27567430; PMCID: PMC5253081.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    47. Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. 2016 Mar 15; 44(3):647-658. Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G. PMID: 26944199; PMCID: PMC4794373.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    48. Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis. PLoS Pathog. 2015 Oct; 11(10):e1005088. Hellman J. PMID: 26425845; PMCID: PMC4591006.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    49. Vascular endothelial cell Toll-like receptor pathways in sepsis. Innate Immun. 2015 Nov; 21(8):827-46. Khakpour S, Wilhelmsen K, Hellman J. PMID: 26403174.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    50. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. PMID: 26196836; PMCID: PMC4537678.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    51. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25; 8(391):ra86. Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. PMID: 26307013; PMCID: PMC5734625.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    52. Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state. J Leukoc Biol. 2015 Dec; 98(6):983-94. Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM. PMID: 26216934.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    53. Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLoS One. 2015; 10(5):e0126906. Feng X, Maze M, Koch LG, Britton SL, Hellman J. PMID: 25978669; PMCID: PMC4433232.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    54. Dual orientation of the outer membrane lipoprotein Pal in Escherichia coli. Microbiology (Reading). 2015 Jun; 161(6):1251-9. Michel LV, Shaw J, MacPherson V, Barnard D, Bettinger J, D'Arcy B, Surendran N, Hellman J, Pichichero ME. PMID: 25808171; PMCID: PMC4635515.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    55. The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. J Biol Chem. 2014 May 09; 289(19):13079-100. Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J. PMID: 24644287; PMCID: PMC4036321.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    56. Quantitative in vitro assay to measure neutrophil adhesion to activated primary human microvascular endothelial cells under static conditions. J Vis Exp. 2013 Aug 23; (78):e50677. Wilhelmsen K, Farrar K, Hellman J. PMID: 23995778; PMCID: PMC3856291.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    57. Extracellular signal-regulated kinase 5, a central regulator of Toll-like receptor signaling in vivo and in vitro (P4193). The Journal of Immunology. 2013 May 1; 190(1_Supplement):112.30-112.30. Wilhelmsen WK, Xu XF, Tran TA, Hellman HJ. .
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    58. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Anesthesiology. 2012 Oct; 117(4):822-35. Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. PMID: 22890118; PMCID: PMC3477877.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    59. Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. J Immunol. 2012 Aug 15; 189(4):2017-22. Lin T, Sammy F, Yang H, Thundivalappil S, Hellman J, Tracey KJ, Warren HS. PMID: 22772444; PMCID: PMC3426910.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    60. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem. 2012 Aug 03; 287(32):26478-94. Wilhelmsen K, Mesa KR, Lucero J, Xu F, Hellman J. PMID: 22707717; PMCID: PMC3410990.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    61. Bacterial lipopeptides and heat-killed Staph aureus modulate lung vascular endothelial permeability via Toll-like receptor 2 (TLR2) (67.3). The Journal of Immunology. 2012 May 1; 188(1_Supplement):67.3-67.3. Hellman HJ, Wilhelmsen WK, Mesa MK, Xu XF. .
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    62. TLR4 and alveolar macrophages mediate lung ischemia reperfusion (IR) sterile inflammatory injury in a mouse model of ventilated lung ischemia (67.6). The Journal of Immunology. 2012 May 1; 188(1_Supplement):67.6-67.6. Prakash PA, Mesa MK, Hellman HJ. .
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    63. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012 Aug; 18(4):602-16. Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. PMID: 22186927; PMCID: PMC3444510.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    64. Toll-like Receptor 2 signaling in human endothelial cells (162.5). The Journal of Immunology. 2011 Apr 1; 186(1_Supplement):162.5-162.5. Wilhelmsen WK, Mesa MK, Hellman HJ. .
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    65. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011 Jan 15; 186(2):1119-30. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. PMID: 21169547; PMCID: PMC3482611.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    66. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. J Leukoc Biol. 2010 Oct; 88(4):605-7. Prakash A, Hellman J. PMID: 20884653.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    67. Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis. 2010 Jan 15; 201(2):223-32. Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM. PMID: 20001600; PMCID: PMC2798011.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    68. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. AIDS. 2008 Mar 12; 22(5):655-8. Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M. PMID: 18317010; PMCID: PMC2810187.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    69. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. PMID: 18055842.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    70. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol. 2007 Aug; 81(15):8180-91. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M. PMID: 17507480; PMCID: PMC1951290.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    71. Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Crit Care Med. 2007 Mar; 35(3):886-92. Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U. PMID: 17255871.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    72. MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol. 2007 Jan 15; 178(2):1164-71. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J. PMID: 17202381.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    73. Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis. Mol Med. 2006 Sep-Oct; 12(9-10):252-8. Valentine CH, Hellman J, Beasley-Topliffe LK, Bagchi A, Warren HS. PMID: 17225874; PMCID: PMC1770012.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    74. Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Crit Care Med. 2005 Mar; 33(3):598-604. Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U. PMID: 15753753.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    75. Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. J Infect Dis. 2005 Mar 15; 191(6):939-48. Liang MD, Bagchi A, Warren HS, Tehan MM, Trigilio JA, Beasley-Topliffe LK, Tesini BL, Lazzaroni JC, Fenton MJ, Hellman J. PMID: 15717270.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    76. Protective efficacy of CAP18106-138-immunoglobulin G in sepsis. J Infect Dis. 2003 Nov 01; 188(9):1382-93. Warren HS, Matyal R, Allaire JE, Yarmush D, Loiselle P, Hellman J, Paton BG, Fink MP. PMID: 14593598.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    77. Inhaled nitric oxide for ARDS: searching for a more focused use. Intensive Care Med. 2003 Oct; 29(10):1623-5. Bigatello LM, Hellman J. PMID: 14635625.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    78. Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. J Infect Dis. 2003 Jul 15; 188(2):286-9. Hellman J, Tehan MM, Warren HS. PMID: 12854085.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    79. Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. J Biol Chem. 2002 Apr 19; 277(16):14274-80. Hellman J, Roberts JD, Tehan MM, Allaire JE, Warren HS. PMID: 11830585.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    80. Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis. J Endotoxin Res. 2001; 7(1):69-72. Hellman J, Warren HS. PMID: 11521086.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    81. Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum. Infect Immun. 2000 May; 68(5):2566-72. Hellman J, Loiselle PM, Tehan MM, Allaire JE, Boyle LA, Kurnick JT, Andrews DM, Sik Kim K, Warren HS. PMID: 10768945; PMCID: PMC97460.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    82. Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5. J Infect Dis. 2000 Mar; 181(3):1034-43. Hellman J, Loiselle PM, Zanzot EM, Allaire JE, Tehan MM, Boyle LA, Kurnick JT, Warren HS. PMID: 10720528.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    83. Antibodies against bacterial membrane proteins. Innate Immunity. 1999 Aug 1; 5(4):213-215. Hellman HJ, Warren WH. .
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    84. Antiendotoxin strategies. Infect Dis Clin North Am. 1999 Jun; 13(2):371-86, ix. Hellman J, Warren HS. PMID: 10340172.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    85. Antiserum against Escherichia coli J5 contains antibodies reactive with outer membrane proteins of heterologous gram-negative bacteria. J Infect Dis. 1997 Nov; 176(5):1260-8. Hellman J, Zanzot EM, Loiselle PM, Amato SF, Black KM, Ge Y, Kurnick JT, Warren HS. PMID: 9359727.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    86. Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. J Biol Chem. 1988 Jan 25; 263(3):1182-7. Sen K, Hellman J, Nikaido H. PMID: 2447086.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
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