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Neonatal Cannabidiol Exposure Impairs Spatial Memory and Disrupts Neuronal Dendritic Morphology in Young Adult Rats. Cannabis Cannabinoid Res. 2024 Sep 10.
Wadhwa M, Chinn GA, Sasaki Russell JM, Hellman J, Sall JW. PMID: 39253840.
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PubMed Mentions: Fields:
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Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo. Front Med (Lausanne). 2024; 11:1412891.
Bokoch MP, Xu F, Govindaraju K, Lloyd E, Tsutsui K, Kothari RP, Adelmann D, Joffre J, Hellman J. PMID: 39021821; PMCID: PMC11252006.
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Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s. J Nat Prod. 2024 04 26; 87(4):639-651.
Roy P, Maturano J, Hasdemir H, Lopez A, Xu F, Hellman J, Tajkhorshid E, Sarlah D, Das A. PMID: 38477310; PMCID: PMC11061835.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Surviving Sepsis Campaign Research Priorities 2023. Crit Care Med. 2024 02 01; 52(2):268-296.
De Backer D, Deutschman CS, Hellman J, Myatra SN, Ostermann M, Prescott HC, Talmor D, Antonelli M, Pontes Azevedo LC, Bauer SR, Kissoon N, Loeches IM, Nunnally M, Tissieres P, Vieillard-Baron A, Coopersmith CM, Surviving Sepsis Campaign Research Committee. PMID: 38240508.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. medRxiv. 2023 Nov 30.
Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS. PMID: 38076828; PMCID: PMC10705660.
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Abstract 14589: Impairment of Endothelial Function by Chronic Cannabis Use: An Interim Analysis of the CANDIDE Study. Circulation. 2023 Nov 7; 148(Suppl_1):a14589-a14589.
Mohammadi ML, Navabzadeh NM, Han HD, Reagan RE, Naughton NJ, Zhou ZL, Almeida AR, Park PK, Uyemura UK, Goyal GN, Rao RP, Hellman HJ, Cheng CJ, Marcus MG, Springer SM. .
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The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats. Cannabis Cannabinoid Res. 2024 Oct; 9(5):e1443-e1451.
Soni I, Chinn GA, Halifax JC, Hellman J, Lynch KL, Sall JW. PMID: 37852006.
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Animals
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Chapter 2 The endocannabinoid system, immunomodulation, and LPS-induced inflammation. Neurobiology and Physiology of the Endocannabinoid System. 2023 Jan 1; 17-34.
Lloyd LE, Nguyen NN, Hellman HJ. .
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Reply to Khatun et al. Am J Respir Crit Care Med. 2022 Nov 01; 206(9):1179-1180.
Joffre J, Matthay MA, Hellman J. PMID: 35839475; PMCID: PMC9704822.
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Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels. Arterioscler Thromb Vasc Biol. 2022 11; 42(11):1333-1350.
Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML. PMID: 36288290; PMCID: PMC9625085.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Am J Respir Crit Care Med. 2022 10 15; 206(8):961-972.
Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group. PMID: 35649173; PMCID: PMC9801996.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive. Biochemistry. 2022 11 01; 61(21):2398-2408.
Roy P, Dennis DG, Eschbach MD, Anand SD, Xu F, Maturano J, Hellman J, Sarlah D, Das A. PMID: 36223199; PMCID: PMC10337483.
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PubMed Mentions:
4 Fields:
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HumansAnimals
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PubMed Mentions:
5 Fields:
Translation:
Humans
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A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery. J Vis Exp. 2022 09 09; (187).
Liao WI, Maruyama D, Kianian F, Tat C, Tian X, Hellman J, Dodd-O JM, Prakash A. PMID: 36155626; PMCID: PMC9752345.
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PubMed Mentions: Fields:
Translation:
Animals
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N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. J Neuroinflammation. 2022 May 24; 19(1):118.
Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J. PMID: 35610647; PMCID: PMC9131699.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Triggering toxicity: How antibiotics can enhance the release of outer membrane vesicles from Escherichia coli during sepsis. The FASEB Journal. 2022 May 13; 36(S1).
Michel ML, Konovalova KA, Hellman HJ, Gaborski GT. .
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Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122]. Bone. 2022 May; 158:116325.
Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. PMID: 35241401.
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Abstract 11496: Increased Pulmonary Microvascular Endothelial Permeability by E-Cigarette Aerosol: The Pathway from Lung to Peripheral Blood Vessels. Circulation. 2021 Nov 16; 144(Suppl_1):a11496-a11496.
Mohammadi ML, Han HD, Fang FX, Xu XF, Derakhshandeh DR, Hellman HJ, Gotts GJ, Springer SM. .
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Abstract 9929: Inhibition of Receptor for Advanced Glycation End Products (RAGE) Reduces E-Cigarette-Induced Increase in Endothelial Permeability. Circulation. 2021 Nov 16; 144(Suppl_1):a9929-a9929.
Han HD, Xu XF, Derakhshandeh DR, Huang HA, Whitlatch WA, Keith KR, Hamburg HN, Ganz GP, Hellman HJ, Schick SS, Springer SM, Mohammadi ML. .
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Isolation of Primary Mouse Lung Endothelial Cells. J Vis Exp. 2021 11 10; (177).
Wong E, Nguyen N, Hellman J. PMID: 34842233; PMCID: PMC11101010.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Crit Care Explor. 2021 Sep; 3(9):e0511.
Martin-Loeches I, Nunnally ME, Hellman J, Lat I, Martin GS, Jog S, Kesecioglu J, De Backer D, Coopersmith CM. PMID: 34514420; PMCID: PMC8425836.
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PubMed Mentions:
6
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ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages. Bone. 2021 12; 153:116129.
Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC. PMID: 34311122; PMCID: PMC8803261.
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16 Fields:
Translation:
HumansCells
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Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Antioxid Redox Signal. 2021 11 20; 35(15):1291-1307.
Joffre J, Hellman J. PMID: 33637016.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness. Crit Care Med. 2021 04 01; 49(4):598-622.
Coopersmith CM, Antonelli M, Bauer SR, Deutschman CS, Evans LE, Ferrer R, Hellman J, Jog S, Kesecioglu J, Kissoon N, Martin-Loeches I, Nunnally ME, Prescott HC, Rhodes A, Talmor D, Tissieres P, De Backer D. PMID: 33591008.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 03 01; 49(3):e315-e326.
Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. PMID: 33481407; PMCID: PMC7892263.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Shock. 2021 03 01; 55(3):349-356.
Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J. PMID: 32826812; PMCID: PMC8139579.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. Int J Antimicrob Agents. 2020 Dec; 56(6):106163.
Michel LV, Gallardo L, Konovalova A, Bauer M, Jackson N, Zavorin M, McNamara C, Pierce J, Cheng S, Snyder E, Hellman J, Pichichero ME. PMID: 32941946.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities. Crit Care Med. 2020 08; 48(8):1217-1232.
Deutschman CS, Hellman J, Ferrer Roca R, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign. PMID: 32697495; PMCID: PMC7365680.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020 08 01; 202(3):361-370.
Joffre J, Hellman J, Ince C, Ait-Oufella H. PMID: 32101446.
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PubMed Mentions:
222 Fields:
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HumansAnimalsCells
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The surviving sepsis campaign: basic/translational science research priorities. Intensive Care Med Exp. 2020 Jul 17; 8(1):31.
Deutschman CS, Hellman J, Roca RF, De Backer D, Coopersmith CM, Research Committee of the Surviving Sepsis Campaign. PMID: 32676795; PMCID: PMC7365694.
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PubMed Mentions:
6
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Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 06 15; 204(12):3339-3350.
Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. PMID: 32385136; PMCID: PMC7276941.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Front Microbiol. 2019; 10:159.
Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. PMID: 30891007; PMCID: PMC6413706.
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PubMed Mentions:
35
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Premise for Standardized Sepsis Models. Shock. 2019 01; 51(1):4-9.
Remick DG, Ayala A, Chaudry IH, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski MF. PMID: 29877959; PMCID: PMC6281773.
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32 Fields:
Translation:
HumansAnimals
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Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Shock. 2019 01; 51(1):33-43.
Hellman J, Bahrami S, Boros M, Chaudry IH, Fritsch G, Gozdzik W, Inoue S, Radermacher P, Singer M, Osuchowski MF, Huber-Lang M. PMID: 29923896.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018 11 15; 3(22).
Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. PMID: 30429363; PMCID: PMC6302947.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock. 2018 10; 50(4):377-380.
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. PMID: 30106875; PMCID: PMC6133201.
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PubMed Mentions:
99 Fields:
Translation:
Animals
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Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp. 2018 Aug 14; 6(1):26.
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. PMID: 30112605; PMCID: PMC6093828.
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42
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Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock. Crit Care Med. 2018 08; 46(8):1334-1356.
Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. PMID: 29957716.
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PubMed Mentions:
48 Fields:
Translation:
Humans
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Surviving sepsis campaign: research priorities for sepsis and septic shock. Intensive Care Med. 2018 Sep; 44(9):1400-1426.
Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. PMID: 29971592; PMCID: PMC7095388.
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PubMed Mentions:
93 Fields:
Translation:
Humans
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Detecting Released Peptidoglycan Associated Lipoprotein (Pal) from Escherichia coli. The FASEB Journal. 2018 Apr 1; 32:526.4-526.4.
Snyder SE, Zavorin ZM, Farquaharson FK, Panullo PN, Pichichero PM, Hellman HJ, Michel ML. .
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Probing the Two Orientations of Pal in Vesiculating E. coli. The FASEB Journal. 2018 Apr 1; 32:671.4-671.4.
Pannullo PN, Zavorin ZM, D'Arcy DB, Farquharson FK, Kaur KR, Surendran SN, Pichichero PM, Hellman HJ, Michel ML. .
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NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice. Front Immunol. 2017; 8:1337.
Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A. PMID: 29163464; PMCID: PMC5671513.
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PubMed Mentions:
15 Fields:
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N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475.
Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. PMID: 28701511; PMCID: PMC5544930.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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20. Critical Care Medicine. 2016 Dec 1; 44(12):91.
Lawton LS, Wilhelmsen WK, Xu XF, Tran TA, Wong WE, Hellman HJ. .
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Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5.
Guan Z, Hellman J, Schumacher M. PMID: 27781082; PMCID: PMC5054801.
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PubMed Mentions:
13 Fields:
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Potentiation and tolerance of toll-like receptor priming in human endothelial cells. Transl Res. 2017 02; 180:53-67.e4.
Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ. PMID: 27567430; PMCID: PMC5253081.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. 2016 Mar 15; 44(3):647-658.
Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G. PMID: 26944199; PMCID: PMC4794373.
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PubMed Mentions:
201 Fields:
Translation:
AnimalsCells
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Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis. PLoS Pathog. 2015 Oct; 11(10):e1005088.
Hellman J. PMID: 26425845; PMCID: PMC4591006.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Vascular endothelial cell Toll-like receptor pathways in sepsis. Innate Immun. 2015 Nov; 21(8):827-46.
Khakpour S, Wilhelmsen K, Hellman J. PMID: 26403174.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9.
Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. PMID: 26196836; PMCID: PMC4537678.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25; 8(391):ra86.
Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. PMID: 26307013; PMCID: PMC5734625.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state. J Leukoc Biol. 2015 Dec; 98(6):983-94.
Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM. PMID: 26216934.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLoS One. 2015; 10(5):e0126906.
Feng X, Maze M, Koch LG, Britton SL, Hellman J. PMID: 25978669; PMCID: PMC4433232.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Dual orientation of the outer membrane lipoprotein Pal in Escherichia coli. Microbiology (Reading). 2015 Jun; 161(6):1251-9.
Michel LV, Shaw J, MacPherson V, Barnard D, Bettinger J, D'Arcy B, Surendran N, Hellman J, Pichichero ME. PMID: 25808171; PMCID: PMC4635515.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. J Biol Chem. 2014 May 09; 289(19):13079-100.
Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J. PMID: 24644287; PMCID: PMC4036321.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Quantitative in vitro assay to measure neutrophil adhesion to activated primary human microvascular endothelial cells under static conditions. J Vis Exp. 2013 Aug 23; (78):e50677.
Wilhelmsen K, Farrar K, Hellman J. PMID: 23995778; PMCID: PMC3856291.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Extracellular signal-regulated kinase 5, a central regulator of Toll-like receptor signaling in vivo and in vitro (P4193). The Journal of Immunology. 2013 May 1; 190(1_Supplement):112.30-112.30.
Wilhelmsen WK, Xu XF, Tran TA, Hellman HJ. .
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Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. Anesthesiology. 2012 Oct; 117(4):822-35.
Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J. PMID: 22890118; PMCID: PMC3477877.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. J Immunol. 2012 Aug 15; 189(4):2017-22.
Lin T, Sammy F, Yang H, Thundivalappil S, Hellman J, Tracey KJ, Warren HS. PMID: 22772444; PMCID: PMC3426910.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem. 2012 Aug 03; 287(32):26478-94.
Wilhelmsen K, Mesa KR, Lucero J, Xu F, Hellman J. PMID: 22707717; PMCID: PMC3410990.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Bacterial lipopeptides and heat-killed Staph aureus modulate lung vascular endothelial permeability via Toll-like receptor 2 (TLR2) (67.3). The Journal of Immunology. 2012 May 1; 188(1_Supplement):67.3-67.3.
Hellman HJ, Wilhelmsen WK, Mesa MK, Xu XF. .
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TLR4 and alveolar macrophages mediate lung ischemia reperfusion (IR) sterile inflammatory injury in a mouse model of ventilated lung ischemia (67.6). The Journal of Immunology. 2012 May 1; 188(1_Supplement):67.6-67.6.
Prakash PA, Mesa MK, Hellman HJ. .
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Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012 Aug; 18(4):602-16.
Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J. PMID: 22186927; PMCID: PMC3444510.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Toll-like Receptor 2 signaling in human endothelial cells (162.5). The Journal of Immunology. 2011 Apr 1; 186(1_Supplement):162.5-162.5.
Wilhelmsen WK, Mesa MK, Hellman HJ. .
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Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011 Jan 15; 186(2):1119-30.
Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J. PMID: 21169547; PMCID: PMC3482611.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge. J Leukoc Biol. 2010 Oct; 88(4):605-7.
Prakash A, Hellman J. PMID: 20884653.
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HumansAnimalsCells
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Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis. 2010 Jan 15; 201(2):223-32.
Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM. PMID: 20001600; PMCID: PMC2798011.
View in:
PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. AIDS. 2008 Mar 12; 22(5):655-8.
Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M. PMID: 18317010; PMCID: PMC2810187.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8.
Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. PMID: 18055842.
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11 Fields:
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AnimalsCells
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MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol. 2007 Aug; 81(15):8180-91.
Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M. PMID: 17507480; PMCID: PMC1951290.
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141 Fields:
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HumansAnimalsCells
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Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Crit Care Med. 2007 Mar; 35(3):886-92.
Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U. PMID: 17255871.
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36 Fields:
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AnimalsCells
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MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol. 2007 Jan 15; 178(2):1164-71.
Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J. PMID: 17202381.
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162 Fields:
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AnimalsCells
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Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis. Mol Med. 2006 Sep-Oct; 12(9-10):252-8.
Valentine CH, Hellman J, Beasley-Topliffe LK, Bagchi A, Warren HS. PMID: 17225874; PMCID: PMC1770012.
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5 Fields:
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HumansAnimals
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Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Crit Care Med. 2005 Mar; 33(3):598-604.
Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U. PMID: 15753753.
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29 Fields:
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AnimalsCells
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Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. J Infect Dis. 2005 Mar 15; 191(6):939-48.
Liang MD, Bagchi A, Warren HS, Tehan MM, Trigilio JA, Beasley-Topliffe LK, Tesini BL, Lazzaroni JC, Fenton MJ, Hellman J. PMID: 15717270.
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44 Fields:
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HumansAnimalsCells
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Protective efficacy of CAP18106-138-immunoglobulin G in sepsis. J Infect Dis. 2003 Nov 01; 188(9):1382-93.
Warren HS, Matyal R, Allaire JE, Yarmush D, Loiselle P, Hellman J, Paton BG, Fink MP. PMID: 14593598.
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3 Fields:
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AnimalsCells
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Inhaled nitric oxide for ARDS: searching for a more focused use. Intensive Care Med. 2003 Oct; 29(10):1623-5.
Bigatello LM, Hellman J. PMID: 14635625.
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Humans
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Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. J Infect Dis. 2003 Jul 15; 188(2):286-9.
Hellman J, Tehan MM, Warren HS. PMID: 12854085.
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9 Fields:
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Cells
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Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. J Biol Chem. 2002 Apr 19; 277(16):14274-80.
Hellman J, Roberts JD, Tehan MM, Allaire JE, Warren HS. PMID: 11830585.
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39 Fields:
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AnimalsCells
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Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis. J Endotoxin Res. 2001; 7(1):69-72.
Hellman J, Warren HS. PMID: 11521086.
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11 Fields:
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Animals
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Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum. Infect Immun. 2000 May; 68(5):2566-72.
Hellman J, Loiselle PM, Tehan MM, Allaire JE, Boyle LA, Kurnick JT, Andrews DM, Sik Kim K, Warren HS. PMID: 10768945; PMCID: PMC97460.
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22 Fields:
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HumansAnimalsCells
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Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5. J Infect Dis. 2000 Mar; 181(3):1034-43.
Hellman J, Loiselle PM, Zanzot EM, Allaire JE, Tehan MM, Boyle LA, Kurnick JT, Warren HS. PMID: 10720528.
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21 Fields:
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HumansAnimalsCells
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Antibodies against bacterial membrane proteins. Innate Immunity. 1999 Aug 1; 5(4):213-215.
Hellman HJ, Warren WH. .
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Antiendotoxin strategies. Infect Dis Clin North Am. 1999 Jun; 13(2):371-86, ix.
Hellman J, Warren HS. PMID: 10340172.
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4 Fields:
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HumansAnimals
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Antiserum against Escherichia coli J5 contains antibodies reactive with outer membrane proteins of heterologous gram-negative bacteria. J Infect Dis. 1997 Nov; 176(5):1260-8.
Hellman J, Zanzot EM, Loiselle PM, Amato SF, Black KM, Ge Y, Kurnick JT, Warren HS. PMID: 9359727.
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9 Fields:
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HumansAnimalsCells
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Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. J Biol Chem. 1988 Jan 25; 263(3):1182-7.
Sen K, Hellman J, Nikaido H. PMID: 2447086.
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55 Fields:
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Cells