Angela Rivers, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address35 Medical Center Way, #903D
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Erythrocyte Mitochondrial Retention in Sickle Cell Disease
    NIH R01HL136622Jan 15, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Mitophagy as Potential Target in Sickle Cell Disease
    NIH R03HL135454Sep 15, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Development of AAV vectors for the phenotypic correction of sickle cell disease
    NIH K01HL103172Jul 1, 2010 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reticulocyte mitochondrial retention increases reactive oxygen species and oxygen consumption in mouse models of sickle cell disease and phlebotomy-induced anemia. Exp Hematol. 2023 Mar 16. Gallivan A, Alejandro M, Kanu A, Zekaryas N, Horneman H, Hong LK, Vinchinsky E, Lavelle D, Diamond AM, Molokie RE, Ramasamy J, Rivers A. PMID: 36934777.
      View in: PubMed   Mentions:    Fields:    
    2. Combinatorial targeting of epigenome-modifying enzymes with small molecule drugs synergistically increases HbF. Blood Adv. 2023 Mar 08. Lavelle D, Ibanez V, Vaitkus K, Zhang X, Ramasamy J, Rivers AE, Saunthararajah Y, Molokie R. PMID: 36884303.
      View in: PubMed   Mentions:    Fields:    
    3. Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana. Pain Med. 2022 08 01; 23(8):1379-1386. Zempsky WT, Yanaros M, Sayeem M, Boruchov D, Piccone CM, Manwani D, Strunk C, Tartaglione I, Colombatti R, Akatue S, Oteng B, Owda A, Bamfo R, Wilson S, Rivers A, Farooq F, Urbonya R, Boatemaa GD, Rao S, Inusa B, Antwi-Boasiako C, Segbefia C, Sey F, Andemariam B, Asare EV, Campbell AD. PMID: 35166851.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research. J Racial Ethn Health Disparities. 2021 02; 8(1):99-106. Campbell AD, Colombatti R, Andemariam B, Strunk C, Tartaglione I, Piccone CM, Manwani D, Asare EV, Boruchov D, Farooq F, Urbonya R, Boatemaa GD, Perrotta S, Sainati L, Rivers A, Rao S, Zempsky W, Sey F, Segbefia C, Inusa B, Antwi-Boasiako C. PMID: 32418182; PMCID: PMC7669607.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    5. A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis. Ann Hematol. 2020 Sep; 99(9):2073-2079. Antwi-Boasiako C, Andemariam B, Colombatti R, Asare EV, Strunk C, Piccone CM, Manwani D, Boruchov D, Farooq F, Urbonya R, Wilson S, Boatemaa GD, Perrotta S, Sainati L, Rivers A, Rao S, Zempsky W, Ekem I, Sey F, Segbefia C, Inusa B, Tartaglione I, Campbell AD. PMID: 32377816; PMCID: PMC7430152.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    6. A new target for fetal hemoglobin reactivation. Haematologica. 2019 12; 104(12):2325-2327. Rivers A, Molokie R, Lavelle D. PMID: 31787612; PMCID: PMC6959183.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons. Exp Hematol. 2018 11; 67:60-64.e2. Rivers A, Vaitkus K, Jagadeeswaran R, Ruiz MA, Ibanez V, Ciceri F, Cavalcanti F, Molokie RE, Saunthararajah Y, Engel JD, DeSimone J, Lavelle D. PMID: 30125603; PMCID: PMC8728698.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data. Am J Physiol Regul Integr Comp Physiol. 2018 10 01; 315(4):R840-R847. Rivers A, Jagadeeswaran R, Lavelle D. PMID: 30067082; PMCID: PMC6734057.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 2017 06; 50:46-52. Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A. PMID: 28238805; PMCID: PMC6263958.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    10. Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons. Blood. 2017 01 12; 129(2):260-263. Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. PMID: 27908882; PMCID: PMC5234223.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    11. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica. 2016 06; 101(6):688-97. Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D. PMID: 26858356; PMCID: PMC5013966.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. Adverse Reactions to Pneumococcal Vaccine in Pediatric and Adolescent Patients with Sickle Cell Disease. Pharmacotherapy. 2015 Jul; 35(7):696-700. Han J, Kemiki O, Hsu LL, Rivers AE. PMID: 26095207; PMCID: PMC5520624.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16; 126(3):386-96. Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. PMID: 26031919; PMCID: PMC4504950.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    14. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model. Exp Hematol. 2015 Jul; 43(7):546-53.e1-3. Rivers A, Vaitkus K, Ruiz MA, Ibanez V, Jagadeeswaran R, Kouznetsova T, DeSimone J, Lavelle D. PMID: 25931013; PMCID: PMC6325640.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    15. Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation. Epigenetics. 2015; 10(5):397-407. Ruiz MA, Rivers A, Ibanez V, Vaitkus K, Mahmud N, DeSimone J, Lavelle D. PMID: 25932923; PMCID: PMC4622718.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy. Immunol Cell Biol. 2014 Feb; 92(2):116-23. Pandya J, Ortiz L, Ling C, Rivers AE, Aslanidi G. PMID: 24217810.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    17. Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo. Cytotherapy. 2013 Aug; 15(8):986-98. Song L, Kauss MA, Kopin E, Chandra M, Ul-Hasan T, Miller E, Jayandharan GR, Rivers AE, Aslanidi GV, Ling C, Li B, Ma W, Li X, Andino LM, Zhong L, Tarantal AF, Yoder MC, Wong KK, Tan M, Chatterjee S, Srivastava A. PMID: 23830234; PMCID: PMC3711144.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    18. Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery. J Control Release. 2013 Oct 28; 171(2):184-92. Choe SW, Terman DS, Rivers AE, Rivera J, Lottenberg R, Sorg BS. PMID: 23871960; PMCID: PMC4162096.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold? PLoS One. 2013; 8(3):e59142. Aslanidi GV, Rivers AE, Ortiz L, Song L, Ling C, Govindasamy L, Van Vliet K, Tan M, Agbandje-McKenna M, Srivastava A. PMID: 23527116; PMCID: PMC3602601.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    20. High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine. 2012 Jun 06; 30(26):3908-17. Aslanidi GV, Rivers AE, Ortiz L, Govindasamy L, Ling C, Jayandharan GR, Zolotukhin S, Agbandje-McKenna M, Srivastava A. PMID: 22497875; PMCID: PMC3356484.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    21. Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses. Hum Gene Ther. 2010 Mar; 21(3):271-83. Jayandharan GR, Zhong L, Sack BK, Rivers AE, Li M, Li B, Herzog RW, Srivastava A. PMID: 19788390; PMCID: PMC2865358.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    22. Congenital cytopenias and bone marrow failure syndromes. Semin Perinatol. 2009 Feb; 33(1):20-8. Rivers A, Slayton WB. PMID: 19167578.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. J Pediatr Hematol Oncol. 2008 Sep; 30(9):708-11. Slayton WB, Patel M, Sola-Visner M, Harris N, Rivers A, Montgomery RR, Friedman KD. PMID: 18776767; PMCID: PMC5592795.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Optimization of recombinant adeno-associated viral vectors for human beta-globin gene transfer and transgene expression. Hum Gene Ther. 2008 Apr; 19(4):365-75. Maina N, Zhong L, Li X, Zhao W, Han Z, Bischof D, Aslanidi G, Zolotukhin S, Weigel-Van Aken KA, Rivers AE, Slayton WB, Yoder MC, Srivastava A. PMID: 18399730.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
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