Angela Rivers, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address35 Medical Center Way, #903D
San Francisco CA 94143
Phone--
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Simons Rock College of Bard, Great Barrington, MABA1993Liberal Arts
    Meharry Medical College, Nashville, TNPhD1998Biomedical Science
    Stanford University, Stanford, CAMD2002Medicine
    University of South Florida, Tampa, FLResident2006Internal Medicine/Pediatrics
    University of Florida, Gainesville, FLAFellowship2010Pediatric Hematology/Oncology

    Collapse Overview 
    Collapse Overview
    Angela Rivers, PhD, MD is a Pediatric Hematologist/Oncologist. It is her career goal to work to improve the lives of both children and adults with sickle cell disease. She has been Principal Investigator for several high-profile studies and received extramural research funding from government agencies, pharmaceutical companies focused on sickle cell drug therapeutics, and the NIH/NHLBI (including K01, R03, and R01 grants). Dr. Rivers is currently the principal investigator of the Rivers Lab. Based in the Department of Pediatrics-Hematology, at UCSF Benioff Children's Hospital Oakland, Rivers Lab is the first to publish the novel discovery that there is a higher presence of red blood cells (RBC) containing mitochondria in sickle cell disease (SCD) mice and human patients compared to normal controls.

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Erythrocyte Mitochondrial Retention in Sickle Cell Disease
    NIH R01HL136622Jan 15, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Mitophagy as Potential Target in Sickle Cell Disease
    NIH R03HL135454Sep 15, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Development of AAV vectors for the phenotypic correction of sickle cell disease
    NIH K01HL103172Jul 1, 2010 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF. Blood Adv. 2023 08 08; 7(15):3891-3902. Ibanez V, Vaitkus K, Zhang X, Ramasamy J, Rivers AE, Saunthararajah Y, Molokie R, Lavelle D. PMID: 36884303; PMCID: PMC10405201.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Reticulocyte mitochondrial retention increases reactive oxygen species and oxygen consumption in mouse models of sickle cell disease and phlebotomy-induced anemia. Exp Hematol. 2023 06; 122:55-62. Gallivan A, Alejandro M, Kanu A, Zekaryas N, Horneman H, Hong LK, Vinchinsky E, Lavelle D, Diamond AM, Molokie RE, Ramasamy J, Rivers A. PMID: 36934777.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana. Pain Med. 2022 08 01; 23(8):1379-1386. Zempsky WT, Yanaros M, Sayeem M, Boruchov D, Piccone CM, Manwani D, Strunk C, Tartaglione I, Colombatti R, Akatue S, Oteng B, Owda A, Bamfo R, Wilson S, Rivers A, Farooq F, Urbonya R, Boatemaa GD, Rao S, Inusa B, Antwi-Boasiako C, Segbefia C, Sey F, Andemariam B, Asare EV, Campbell AD. PMID: 35166851.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research. J Racial Ethn Health Disparities. 2021 02; 8(1):99-106. Campbell AD, Colombatti R, Andemariam B, Strunk C, Tartaglione I, Piccone CM, Manwani D, Asare EV, Boruchov D, Farooq F, Urbonya R, Boatemaa GD, Perrotta S, Sainati L, Rivers A, Rao S, Zempsky W, Sey F, Segbefia C, Inusa B, Antwi-Boasiako C. PMID: 32418182; PMCID: PMC7669607.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis. Ann Hematol. 2020 Sep; 99(9):2073-2079. Antwi-Boasiako C, Andemariam B, Colombatti R, Asare EV, Strunk C, Piccone CM, Manwani D, Boruchov D, Farooq F, Urbonya R, Wilson S, Boatemaa GD, Perrotta S, Sainati L, Rivers A, Rao S, Zempsky W, Ekem I, Sey F, Segbefia C, Inusa B, Tartaglione I, Campbell AD. PMID: 32377816; PMCID: PMC7430152.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    6. A new target for fetal hemoglobin reactivation. Haematologica. 2019 12; 104(12):2325-2327. Rivers A, Molokie R, Lavelle D. PMID: 31787612; PMCID: PMC6959183.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons. Exp Hematol. 2018 11; 67:60-64.e2. Rivers A, Vaitkus K, Jagadeeswaran R, Ruiz MA, Ibanez V, Ciceri F, Cavalcanti F, Molokie RE, Saunthararajah Y, Engel JD, DeSimone J, Lavelle D. PMID: 30125603; PMCID: PMC8728698.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data. Am J Physiol Regul Integr Comp Physiol. 2018 10 01; 315(4):R840-R847. Rivers A, Jagadeeswaran R, Lavelle D. PMID: 30067082; PMCID: PMC6734057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Evolving treatment paradigms in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2017 12 08; 2017(1):440-446. Jagadeeswaran R, Rivers A. PMID: 29222291; PMCID: PMC6142561.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 2017 06; 50:46-52. Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A. PMID: 28238805; PMCID: PMC6263958.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    11. Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons. Blood. 2017 01 12; 129(2):260-263. Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. PMID: 27908882; PMCID: PMC5234223.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    12. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica. 2016 06; 101(6):688-97. Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D. PMID: 26858356; PMCID: PMC5013966.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    13. Adverse Reactions to Pneumococcal Vaccine in Pediatric and Adolescent Patients with Sickle Cell Disease. Pharmacotherapy. 2015 Jul; 35(7):696-700. Han J, Kemiki O, Hsu LL, Rivers AE. PMID: 26095207; PMCID: PMC5520624.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16; 126(3):386-96. Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. PMID: 26031919; PMCID: PMC4504950.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    15. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model. Exp Hematol. 2015 Jul; 43(7):546-53.e1-3. Rivers A, Vaitkus K, Ruiz MA, Ibanez V, Jagadeeswaran R, Kouznetsova T, DeSimone J, Lavelle D. PMID: 25931013; PMCID: PMC6325640.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    16. Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation. Epigenetics. 2015; 10(5):397-407. Ruiz MA, Rivers A, Ibanez V, Vaitkus K, Mahmud N, DeSimone J, Lavelle D. PMID: 25932923; PMCID: PMC4622718.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy. Immunol Cell Biol. 2014 Feb; 92(2):116-23. Pandya J, Ortiz L, Ling C, Rivers AE, Aslanidi G. PMID: 24217810.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    18. Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo. Cytotherapy. 2013 Aug; 15(8):986-98. Song L, Kauss MA, Kopin E, Chandra M, Ul-Hasan T, Miller E, Jayandharan GR, Rivers AE, Aslanidi GV, Ling C, Li B, Ma W, Li X, Andino LM, Zhong L, Tarantal AF, Yoder MC, Wong KK, Tan M, Chatterjee S, Srivastava A. PMID: 23830234; PMCID: PMC3711144.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    19. Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery. J Control Release. 2013 Oct 28; 171(2):184-92. Choe SW, Terman DS, Rivers AE, Rivera J, Lottenberg R, Sorg BS. PMID: 23871960; PMCID: PMC4162096.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold? PLoS One. 2013; 8(3):e59142. Aslanidi GV, Rivers AE, Ortiz L, Song L, Ling C, Govindasamy L, Van Vliet K, Tan M, Agbandje-McKenna M, Srivastava A. PMID: 23527116; PMCID: PMC3602601.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    21. High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine. 2012 Jun 06; 30(26):3908-17. Aslanidi GV, Rivers AE, Ortiz L, Govindasamy L, Ling C, Jayandharan GR, Zolotukhin S, Agbandje-McKenna M, Srivastava A. PMID: 22497875; PMCID: PMC3356484.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    22. Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses. Hum Gene Ther. 2010 Mar; 21(3):271-83. Jayandharan GR, Zhong L, Sack BK, Rivers AE, Li M, Li B, Herzog RW, Srivastava A. PMID: 19788390; PMCID: PMC2865358.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    23. Congenital cytopenias and bone marrow failure syndromes. Semin Perinatol. 2009 Feb; 33(1):20-8. Rivers A, Slayton WB. PMID: 19167578.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. J Pediatr Hematol Oncol. 2008 Sep; 30(9):708-11. Slayton WB, Patel M, Sola-Visner M, Harris N, Rivers A, Montgomery RR, Friedman KD. PMID: 18776767; PMCID: PMC5592795.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Optimization of recombinant adeno-associated viral vectors for human beta-globin gene transfer and transgene expression. Hum Gene Ther. 2008 Apr; 19(4):365-75. Maina N, Zhong L, Li X, Zhao W, Han Z, Bischof D, Aslanidi G, Zolotukhin S, Weigel-Van Aken KA, Rivers AE, Slayton WB, Yoder MC, Srivastava A. PMID: 18399730.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    Angela's Networks
    Concepts (165)
    Derived automatically from this person's publications.
    _
    Co-Authors (3)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _