Carolyn Sangokoya, MD, PhD

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
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    Collapse Education and Training
    Stanford University, Palo Alto, CAAB2003Human Biology (conc: Molecular Genetics)
    Duke University School of Medicine, Durham, NCMD2012Medical Scientist Training Program (MSTP)
    Duke University , Durham, NCPhD2011Genetics and Genomics
    University of California, San FranciscoResidency2015Anatomic Pathology
    University of California, San FranciscoFellowship2015Gastrointestinal and Hepatobiliary Pathology
    University of California, San FranciscoFellowship2015Surgical Pathology
    University of California, San FranciscoFellowship2021Postdoctoral Fellow
    University of California, San Francisco2021Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    NIDDK/UCSF Liver Center2023  - 2025Pilot/Feasibility Award
    Burroughs Wellcome Fund2022  - 2027Career Award for Medical Scientists
    American Society for Clinical Investigation2022ASCI Young Physician Scientist Award
    UCSF School of Medicine2021  - 2024John A. Watson Faculty Scholar
    Gordon Research Conferences2022Session Chair, Travel Award “Post-Transcriptional Gene Regulation” (2022)
    UCSF2017Program for Breakthrough Biomedical Research Postdoc Independent Research Award
    UCSF2015  - 2016Eli and Edythe Broad Regeneration Medicine and Stem Cell Fellowship
    United States and Canadian Academy of Pathology2015Stowell Orbison (selected best pathology trainee abstracts)
    United States and Canadian Academy of Pathology2014Stowell Orbison (selected best pathology trainee abstracts)
    Duke University School of Medicine2012Dean’s Recognition Award, outstanding performance
    The Aspen Institute2007Aspen Health Forum Fellow

    Collapse Overview 
    Collapse Overview
    Carolyn Sangokoya, MD, PhD, is a physician-scientist, board-certified pathologist, and Assistant Professor in the Department of Pathology at University of California, San Francisco. Dr. Sangokoya's broader scientific mission is to discover and build molecular tools to re-engineer and re-wire cell fates for targeted plasticity and regenerative medicine. Dr. Sangokoya completed her medical and graduate training as part of the Medical Scientist Training Program at Duke University, where she discovered roles for microRNAs in oxidative stress and cellular iron homeostasis during her graduate studies with Jen-Tsan Ashley Chi in the Duke University Program in Genetics and Genomics. At UCSF, she completed her post-graduate training in Anatomic Pathology, Surgical Pathology, and Gastrointestinal/Hepatobiliary Pathology through the Department of Pathology Physician-Scientist Pathway, and postdoctoral studies in stem cell and regenerative biology with Robert Blelloch at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, where she defined an axis of post-transcriptional control, endocytosis, and signal transduction essential for multiple aspects of stem cell biology. Dr. Sangokoya is a recipient of the K08 Career Development Award from the NIH/NICHD to decipher post-transcriptional regulation of cell fate in early mammalian development, as well as a recipient of the Burroughs Wellcome Fund Career Award for Medical Scientists.

    Dr. Sangokoya’s clinical interests are primarily in human liver pathobiology and diagnostics for precision-based medicine and regenerative therapies focused on steatotic liver disease and metabolic dysfunction associated steatohepatitis (MASH, formerly NASH), a leading cause of chronic liver disease, cirrhosis, and transplantation. As a stem cell biologist, her basic science research interests are in dissecting the molecular networks that fine-tune the wiring and re-wiring of cell fates in mammalian stem cell-based models, leveraging genome engineering, quantitative cell biology, RNA sequencing, imaging, and cytometry at single-cell resolution.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH K08HD105017Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Mapping post-transcriptional RNA binding regulatory networks within embryonic stem cell fate transition
    NIH F32HD088051Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Measuring Endocytosis and Endosomal Uptake at Single Cell Resolution. Methods Mol Biol. 2022; 2490:57-67. Sangokoya C. PMID: 35486239.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20625-20635. Sangokoya C, Blelloch R. PMID: 32788350; PMCID: PMC7456128.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer Metab. 2013 Dec 23; 1(1):23. Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT. PMID: 24359630; PMCID: PMC4178214.
      View in: PubMed   Mentions: 104  
    4. Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin. PLoS Genet. 2013 Apr; 9(4):e1003408. Sangokoya C, Doss JF, Chi JT. PMID: 23593016; PMCID: PMC3616902.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    5. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood. 2010 Nov 18; 116(20):4338-48. Sangokoya C, Telen MJ, Chi JT. PMID: 20709907; PMCID: PMC2993631.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    6. Isolation and characterization of microRNAs of human mature erythrocytes. Methods Mol Biol. 2010; 667:193-203. Sangokoya C, LaMonte G, Chi JT. PMID: 20827535; PMCID: PMC4347925.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    7. Look to behavioral economics. Health Aff (Millwood). 2008 May-Jun; 27(3):896. Sangokoya C. PMID: 18474989.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. SNPkit: an efficient approach to systematic evaluation of candidate single nucleotide polymorphisms in public databases. Biotechniques. 2002 Oct; 33(4):822, 824-6, 828 passim. Hao K, Niu T, Sangokoya C, Li J, Xu X. PMID: 12398191.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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