Loading...

Roger Nicoll, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address600 16th Street
San Francisco CA 94158
Phone415-476-2018
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    2011 Excitatory Synapses and Brain Function GRC
    NIH/NIMH R13MH093928Jun 1, 2011 - Aug 31, 2015
    Role: Co-Principal Investigator
    Synaptic Glutamate Receptor Trafficking
    NIH/NIMH R01MH080379Jun 1, 2007 - Apr 30, 2017
    Role: Principal Investigator
    AMPA Receptor Subunits and Plasticity
    NIH/NIMH R01MH070957Mar 11, 2004 - Feb 29, 2020
    Role: Principal Investigator
    AMPA Receptor Subunits and Plasticity
    NIH/NIMH R56MH070957Mar 11, 2004 - Feb 28, 2015
    Role: Principal Investigator
    Synaptic signaling regulated by MALS family PDZ proteins
    NIH/NIMH R01MH070062Dec 1, 2003 - Nov 30, 2008
    Role: Principal Investigator
    ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELS
    NIH/NIMH P50MH063981Aug 15, 2001 - Jul 31, 2007
    Role: Principal Investigator
    SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    NIH/NIDA R01DA010268Dec 15, 1996 - Nov 30, 2002
    Role: Principal Investigator
    LONGTERM CHANGES IN THE MAMMALIAN BRAIN
    NIH/NIMH P50MH048200Sep 1, 1991 - Aug 31, 2002
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    CENTRAL SEROTONIN RECEPTORS: IONIC AND MOLECULAR MECHAN
    NIH/NINDS R01NS024205Dec 1, 1986 - Nov 30, 1994
    Role: Principal Investigator
    NEUROTRANSMITTER EFFECTS ON LOCAL NEURONAL CIRCUITS
    NIH/NIMH R01MH038256Dec 1, 1983 - Nov 30, 1986
    Role: Principal Investigator
    LOCAL NEURONAL CIRCUITS IN THE CENTRAL NERVOUS SYSTEM
    NIH/NIMH K05MH000437Jun 1, 1983 - May 31, 1998
    Role: Principal Investigator
    LOCAL NEURONAL CIRCUITS IN THE CNS
    NIH/NIMH K02MH000437Jun 1, 1983 - May 31, 1988
    Role: Principal Investigator
    Cellular and Molecular Substrates of Synaptic Plasticity
    NIH/NIMH R37MH038256Jan 1, 1983 - Feb 28, 2017
    Role: Principal Investigator
    Function and development in the synapse
    NIH P01NS016033Apr 1, 1980 - Jun 30, 2009
    Role: Co-Investigator
    Predoctoral Training in Neurobiology
    NIH/NIGMS T32GM007449Sep 1, 1977 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll R. The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. Nat Commun. 2018 May 25; 9(1):2069. PMID: 29802289.
      View in: PubMed
    2. Tao W, Díaz-Alonso J, Sheng N, Nicoll R. Postsynaptic d1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin. Proc Natl Acad Sci U S A. 2018 May 21. PMID: 29784783.
      View in: PubMed
    3. Nguyen QA, Nicoll R. The GABAA Receptor ß Subunit Is Required for Inhibitory Transmission. Neuron. 2018 Apr 20. PMID: 29706582.
      View in: PubMed
    4. Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll R. LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15):3948-3953. PMID: 29581259.
      View in: PubMed
    5. Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll R, Edwards RH. A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. Nat Commun. 2018 01 23; 9(1):330. PMID: 29362376.
      View in: PubMed
    6. Horn ME, Nicoll R. Somatostatin and parvalbumin inhibitory synapses onto hippocampal pyramidal neurons are regulated by distinct mechanisms. Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3):589-594. PMID: 29295931.
      View in: PubMed
    7. Ancona Esselmann SG, Díaz-Alonso J, Levy JM, Bemben MA, Nicoll R. Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2. Proc Natl Acad Sci U S A. 2017 Dec 12; 114(50):13266-13271. PMID: 29180434.
      View in: PubMed
    8. Lomash RM, Sheng N, Li Y, Nicoll R, Roche KW. Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1. J Biol Chem. 2017 09 15; 292(37):15369-15377. PMID: 28717010.
      View in: PubMed
    9. Díaz-Alonso J, Sun YJ, Granger AJ, Levy JM, Blankenship SM, Nicoll R. Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):7136-7141. PMID: 28630296.
      View in: PubMed
    10. Won S, Levy JM, Nicoll R, Roche KW. MAGUKs: multifaceted synaptic organizers. Curr Opin Neurobiol. 2017 04; 43:94-101. PMID: 28236779.
      View in: PubMed
    11. Sheng N, Shi YS, Nicoll R. Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1159-1164. PMID: 28100490.
      View in: PubMed
    12. Levy JM, Nicoll R. Membrane-associated guanylate kinase dynamics reveal regional and developmental specificity of synapse stability. J Physiol. 2017 Mar 01; 595(5):1699-1709. PMID: 27861918.
      View in: PubMed
    13. Nicoll R. A Brief History of Long-Term Potentiation. Neuron. 2017 Jan 18; 93(2):281-290. PMID: 28103477.
      View in: PubMed
    14. Nguyen QA, Horn ME, Nicoll R. Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses. Elife. 2016 11 02; 5. PMID: 27805570.
      View in: PubMed
    15. Sheng N, Yang J, Silm K, Edwards RH, Nicoll R. A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons. Neuropharmacology. 2017 Mar 15; 115:4-9. PMID: 27567940.
      View in: PubMed
    16. Won S, Incontro S, Nicoll R, Roche KW. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4736-44. PMID: 27457929.
      View in: PubMed
    17. Herring BE, Nicoll R. Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2264-9. PMID: 26858404; PMCID: PMC4776457.
    18. Herring BE, Nicoll R. Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking. Annu Rev Physiol. 2016; 78:351-65. PMID: 26863325.
      View in: PubMed
    19. Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll R. Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife. 2015 Dec 31; 4. PMID: 26720915; PMCID: PMC4749551.
    20. Chen X, Levy JM, Hou A, Winters C, Azzam R, Sousa AA, Leapman RD, Nicoll R, Reese TS. PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6983-92. PMID: 26604311; PMCID: PMC4687590.
    21. Levy JM, Chen X, Reese TS, Nicoll R. Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss. Neuron. 2015 Aug 05; 87(3):534-48. PMID: 26247861; PMCID: PMC4596923.
    22. Bemben MA, Shipman SL, Nicoll R, Roche KW. The cellular and molecular landscape of neuroligins. Trends Neurosci. 2015 Aug; 38(8):496-505. PMID: 26209464.
      View in: PubMed
    23. Herring BE, Silm K, Edwards RH, Nicoll R. Is Aspartate an Excitatory Neurotransmitter? J Neurosci. 2015 Jul 15; 35(28):10168-71. PMID: 26180193; PMCID: PMC4502257.
    24. Lovero KL, Fukata Y, Granger AJ, Fukata M, Nicoll R. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4129-37. PMID: 26178195; PMCID: PMC4522810.
    25. Bemben MA, Nguyen QA, Wang T, Li Y, Nicoll R, Roche KW. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2551-6. PMID: 25675530; PMCID: PMC4345621.
    26. Yamazaki M, Le Pichon CE, Jackson AC, Cerpas M, Sakimura K, Scearce-Levie K, Nicoll R. Relative contribution of TARPs ?-2 and ?-7 to cerebellar excitatory synaptic transmission and motor behavior. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):E371-9. PMID: 25583485; PMCID: PMC4313851.
    27. Incontro S, Asensio CS, Edwards RH, Nicoll R. Efficient, complete deletion of synaptic proteins using CRISPR. Neuron. 2014 Sep 03; 83(5):1051-7. PMID: 25155957; PMCID: PMC4195490.
    28. Granger AJ, Nicoll R. LTD expression is independent of glutamate receptor subtype. Front Synaptic Neurosci. 2014; 6:15. PMID: 25071549; PMCID: PMC4086023.
    29. Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll R, von Zastrow M. Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 2014 Apr 02; 82(1):55-62. PMID: 24698268; PMCID: PMC4029335.
    30. Fu Y, Tucciarone JM, Espinosa JS, Sheng N, Darcy DP, Nicoll R, Huang ZJ, Stryker MP. A cortical circuit for gain control by behavioral state. Cell. 2014 Mar 13; 156(6):1139-1152. PMID: 24630718; PMCID: PMC4041382.
    31. Bemben MA, Shipman SL, Hirai T, Herring BE, Li Y, Badger JD, Nicoll R, Diamond JS, Roche KW. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci. 2014 Jan; 17(1):56-64. PMID: 24336150; PMCID: PMC3943352.
    32. Granger AJ, Nicoll R. Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130136. PMID: 24298139; PMCID: PMC3843869.
    33. Huganir RL, Nicoll R. AMPARs and synaptic plasticity: the last 25 years. Neuron. 2013 Oct 30; 80(3):704-17. PMID: 24183021; PMCID: PMC4195488.
    34. Shipman SL, Herring BE, Suh YH, Roche KW, Nicoll R. Distance-dependent scaling of AMPARs is cell-autonomous and GluA2 dependent. J Neurosci. 2013 Aug 14; 33(33):13312-9. PMID: 23946389; PMCID: PMC3742921.
    35. Lovero KL, Blankenship SM, Shi Y, Nicoll R. SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. PLoS One. 2013; 8(6):e66171. PMID: 23785483; PMCID: PMC3681968.
    36. Lu W, Bushong EA, Shih TP, Ellisman MH, Nicoll R. The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function. Neuron. 2013 May 08; 78(3):433-9. PMID: 23664612; PMCID: PMC3666354.
    37. Herring BE, Shi Y, Suh YH, Zheng CY, Blankenship SM, Roche KW, Nicoll R. Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 2013 Mar 20; 77(6):1083-96. PMID: 23522044; PMCID: PMC3652566.
    38. Sanz-Clemente A, Gray JA, Ogilvie KA, Nicoll R, Roche KW. Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Cell Rep. 2013 Mar 28; 3(3):607-14. PMID: 23478024.
      View in: PubMed
    39. Nicoll R, Roche KW. Long-term potentiation: peeling the onion. Neuropharmacology. 2013 Nov; 74:18-22. PMID: 23439383; PMCID: PMC3718856.
    40. Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll R. LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature. 2013 Jan 24; 493(7433):495-500. PMID: 23235828; PMCID: PMC3998843.
    41. Shipman SL, Nicoll R. Dimerization of postsynaptic neuroligin drives synaptic assembly via transsynaptic clustering of neurexin. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19432-7. PMID: 23129658; PMCID: PMC3511127.
    42. Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll R, Roche KW. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19426-31. PMID: 23129617; PMCID: PMC3511152.
    43. Chen BS, Gray JA, Sanz-Clemente A, Wei Z, Thomas EV, Nicoll R, Roche KW. SAP102 mediates synaptic clearance of NMDA receptors. Cell Rep. 2012 Nov 29; 2(5):1120-8. PMID: 23103165; PMCID: PMC3513525.
    44. Shipman SL, Nicoll R. A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP. Neuron. 2012 Oct 18; 76(2):309-16. PMID: 23083734; PMCID: PMC3998838.
    45. Gray JA, Nicoll R. Thinking outside the synapse: glycine at extrasynaptic NMDA receptors. Cell. 2012 Aug 03; 150(3):455-6. PMID: 22863001.
      View in: PubMed
    46. Sanz-Clemente A, Nicoll R, Roche KW. Diversity in NMDA receptor composition: many regulators, many consequences. Neuroscientist. 2013 Feb; 19(1):62-75. PMID: 22343826.
      View in: PubMed
    47. Jackson AC, Nicoll R. Stargazing from a new vantage--TARP modulation of AMPA receptor pharmacology. J Physiol. 2011 Dec 15; 589(Pt 24):5909-10. PMID: 22174138; PMCID: PMC3286667.
    48. Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll R. Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron. 2011 Sep 22; 71(6):1085-101. PMID: 21943605; PMCID: PMC3183990.
    49. Granger AJ, Gray JA, Lu W, Nicoll R. Genetic analysis of neuronal ionotropic glutamate receptor subunits. J Physiol. 2011 Sep 01; 589(17):4095-101. PMID: 21768264; PMCID: PMC3180569.
    50. Jackson AC, Milstein AD, Soto D, Farrant M, Cull-Candy SG, Nicoll R. Probing TARP modulation of AMPA receptor conductance with polyamine toxins. J Neurosci. 2011 May 18; 31(20):7511-20. PMID: 21593335; PMCID: PMC3164836.
    51. Shipman SL, Schnell E, Hirai T, Chen BS, Roche KW, Nicoll R. Functional dependence of neuroligin on a new non-PDZ intracellular domain. Nat Neurosci. 2011 Jun; 14(6):718-26. PMID: 21532576; PMCID: PMC3171182.
    52. Jackson AC, Nicoll R. The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits. Neuron. 2011 Apr 28; 70(2):178-99. PMID: 21521608; PMCID: PMC3119519.
    53. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll R, Shah NM, Julius D, Basbaum AI. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77. PMID: 21451044; PMCID: PMC3087977.
    54. Jackson AC, Nicoll R. Stargazin (TARP gamma-2) is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells. J Neurosci. 2011 Mar 16; 31(11):3939-52. PMID: 21411637; PMCID: PMC3104604.
    55. Lu W, Isozaki K, Roche KW, Nicoll R. Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22266-71. PMID: 21135237; PMCID: PMC3009812.
    56. Goold CP, Nicoll R. Single-cell optogenetic excitation drives homeostatic synaptic depression. Neuron. 2010 Nov 04; 68(3):512-28. PMID: 21040851; PMCID: PMC3111089.
    57. Lu W, Gray JA, Granger AJ, During MJ, Nicoll R. Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit. J Neurophysiol. 2011 Feb; 105(2):923-8. PMID: 20980546; PMCID: PMC3059181.
    58. Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll R, Moriyama Y. Metabolic control of vesicular glutamate transport and release. Neuron. 2010 Oct 06; 68(1):99-112. PMID: 20920794; PMCID: PMC2978156.
    59. Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll R. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16315-9. PMID: 20805473; PMCID: PMC2941340.
    60. Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll R, Jentsch TJ. The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10232-7. PMID: 20534576; PMCID: PMC2890451.
    61. Howard MA, Elias GM, Elias LA, Swat W, Nicoll R. The role of SAP97 in synaptic glutamate receptor dynamics. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3805-10. PMID: 20133708; PMCID: PMC2840522.
    62. Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll R, Fukata M. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3799-804. PMID: 20133599; PMCID: PMC2840530.
    63. Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll R, Edwards RH. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010 Jan 14; 65(1):66-79. PMID: 20152114; PMCID: PMC3119527.
    64. Milstein AD, Nicoll R. TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11348-51. PMID: 19549880; PMCID: PMC2708767.
    65. Shi Y, Lu W, Milstein AD, Nicoll R. The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type. Neuron. 2009 Jun 11; 62(5):633-40. PMID: 19524523; PMCID: PMC3119531.
    66. Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll R. Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron. 2009 Apr 30; 62(2):254-68. PMID: 19409270; PMCID: PMC3632349.
    67. Jackson AC, Nicoll R. Neuroscience: AMPA receptors get 'pickled'. Nature. 2009 Apr 02; 458(7238):585-6. PMID: 19340072; PMCID: PMC2716117.
    68. Tzingounis AV, Nicoll R. Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19974-9. PMID: 19060215; PMCID: PMC2604953.
    69. Menuz K, Nicoll R. Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice. J Neurosci. 2008 Oct 15; 28(42):10599-603. PMID: 18923036; PMCID: PMC3164835.
    70. Kerchner GA, Nicoll R. Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neurosci. 2008 Nov; 9(11):813-25. PMID: 18854855; PMCID: PMC2819160.
    71. Menuz K, O'Brien JL, Karmizadegan S, Bredt DS, Nicoll R. TARP redundancy is critical for maintaining AMPA receptor function. J Neurosci. 2008 Aug 27; 28(35):8740-6. PMID: 18753375; PMCID: PMC3159041.
    72. Milstein AD, Nicoll R. Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits. Trends Pharmacol Sci. 2008 Jul; 29(7):333-9. PMID: 18514334; PMCID: PMC2819157.
    73. Menuz K, Kerchner GA, O'Brien JL, Nicoll R. Critical role for TARPs in early development despite broad functional redundancy. Neuropharmacology. 2009 Jan; 56(1):22-9. PMID: 18634809; PMCID: PMC3111090.
    74. Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll R, Julius D. Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci. 2008 Jul; 11(7):772-9. PMID: 18568022; PMCID: PMC3072296.
    75. Adesnik H, Li G, During MJ, Pleasure SJ, Nicoll R. NMDA receptors inhibit synapse unsilencing during brain development. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5597-602. PMID: 18375768; PMCID: PMC2291097.
    76. Li G, Adesnik H, Li J, Long J, Nicoll R, Rubenstein JL, Pleasure SJ. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci. 2008 Jan 30; 28(5):1085-98. PMID: 18234887; PMCID: PMC3072297.
    77. Panicker S, Brown K, Nicoll R. Synaptic AMPA receptor subunit trafficking is independent of the C terminus in the GluR2-lacking mouse. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1032-7. PMID: 18195349; PMCID: PMC2242677.
    78. Tomita S, Byrd RK, Rouach N, Bellone C, Venegas A, O'Brien JL, Kim KS, Olsen O, Nicoll R, Bredt DS. AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18784-8. PMID: 18000041; PMCID: PMC2141854.
    79. Menuz K, Stroud RM, Nicoll R, Hays FA. TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science. 2007 Nov 02; 318(5851):815-7. PMID: 17975069.
      View in: PubMed
    80. Milstein AD, Zhou W, Karimzadegan S, Bredt DS, Nicoll R. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron. 2007 Sep 20; 55(6):905-18. PMID: 17880894; PMCID: PMC3167227.
    81. Bellone C, Nicoll R. Rapid bidirectional switching of synaptic NMDA receptors. Neuron. 2007 Sep 06; 55(5):779-85. PMID: 17785184.
      View in: PubMed
    82. Kam K, Nicoll R. Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle. J Neurosci. 2007 Aug 22; 27(34):9192-200. PMID: 17715355.
      View in: PubMed
    83. Elias GM, Nicoll R. Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins. Trends Cell Biol. 2007 Jul; 17(7):343-52. PMID: 17644382.
      View in: PubMed
    84. Kato AS, Zhou W, Milstein AD, Knierman MD, Siuda ER, Dotzlaf JE, Yu H, Hale JE, Nisenbaum ES, Nicoll R, Bredt DS. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J Neurosci. 2007 May 02; 27(18):4969-77. PMID: 17475805.
      View in: PubMed
    85. Adesnik H, Nicoll R. Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation. J Neurosci. 2007 Apr 25; 27(17):4598-602. PMID: 17460072.
      View in: PubMed
    86. Tzingounis AV, Kobayashi M, Takamatsu K, Nicoll R. Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Neuron. 2007 Feb 15; 53(4):487-93. PMID: 17296551; PMCID: PMC1832111.
    87. Tzingounis AV, Nicoll R. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Neuron. 2006 Nov 09; 52(3):403-7. PMID: 17088207.
      View in: PubMed
    88. Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll R. Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron. 2006 Oct 19; 52(2):307-20. PMID: 17046693.
      View in: PubMed
    89. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll R, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science. 2006 Sep 22; 313(5794):1792-5. PMID: 16990550.
      View in: PubMed
    90. Tomita S, Shenoy A, Fukata Y, Nicoll R, Bredt DS. Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology. 2007 Jan; 52(1):87-91. PMID: 16919685.
      View in: PubMed
    91. Morishita W, Lu W, Smith GB, Nicoll R, Bear MF, Malenka RC. Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology. 2007 Jan; 52(1):71-6. PMID: 16899258.
      View in: PubMed
    92. Voglmaier SM, Kam K, Yang H, Fortin DL, Hua Z, Nicoll R, Edwards RH. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron. 2006 Jul 06; 51(1):71-84. PMID: 16815333.
      View in: PubMed
    93. Tomita S, Sekiguchi M, Wada K, Nicoll R, Bredt DS. Stargazin controls the pharmacology of AMPA receptor potentiators. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10064-7. PMID: 16785437; PMCID: PMC1502506.
    94. Nicoll R, Tomita S, Bredt DS. Auxiliary subunits assist AMPA-type glutamate receptors. Science. 2006 Mar 03; 311(5765):1253-6. PMID: 16513974.
      View in: PubMed
    95. Olsen O, Moore KA, Nicoll R, Bredt DS. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Curr Opin Cell Biol. 2006 Apr; 18(2):223-7. PMID: 16504495.
      View in: PubMed
    96. Adesnik H, Nicoll R, England PM. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron. 2005 Dec 22; 48(6):977-85. PMID: 16364901.
      View in: PubMed
    97. Nicoll R, Schmitz D. Synaptic plasticity at hippocampal mossy fibre synapses. Nat Rev Neurosci. 2005 Nov; 6(11):863-76. PMID: 16261180.
      View in: PubMed
    98. Rouach N, Byrd K, Petralia RS, Elias GM, Adesnik H, Tomita S, Karimzadegan S, Kealey C, Bredt DS, Nicoll R. TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nat Neurosci. 2005 Nov; 8(11):1525-33. PMID: 16222232.
      View in: PubMed
    99. Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll R, Bredt DS. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005 Sep 26; 170(7):1127-34. PMID: 16186258; PMCID: PMC2171538.
    100. Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll R, Bredt DS. Molecular constituents of neuronal AMPA receptors. J Cell Biol. 2005 May 09; 169(3):399-404. PMID: 15883194; PMCID: PMC2171936.
    101. Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll R, Bredt DS. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature. 2005 Jun 23; 435(7045):1052-8. PMID: 15858532.
      View in: PubMed
    102. Kato A, Rouach N, Nicoll R, Bredt DS. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5600-5. PMID: 15809437; PMCID: PMC556250.
    103. Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll R, McCormick JA, Wang J, Pearce D, Lang F. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 01; 565(Pt 2):381-90. PMID: 15774536; PMCID: PMC1464516.
    104. Vandenberghe W, Nicoll R, Bredt DS. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. J Neurosci. 2005 Feb 02; 25(5):1095-102. PMID: 15689545.
      View in: PubMed
    105. Tomita S, Stein V, Stocker TJ, Nicoll R, Bredt DS. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 2005 Jan 20; 45(2):269-77. PMID: 15664178.
      View in: PubMed
    106. Vandenberghe W, Nicoll R, Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):485-90. PMID: 15630087; PMCID: PMC544314.
    107. Fukata M, Fukata Y, Adesnik H, Nicoll R, Bredt DS. Identification of PSD-95 palmitoylating enzymes. Neuron. 2004 Dec 16; 44(6):987-96. PMID: 15603741.
      View in: PubMed
    108. Nicoll R, Alger BE. The brain's own marijuana. Sci Am. 2004 Dec; 291(6):68-75. PMID: 15597982.
      View in: PubMed
    109. Nicoll R. My close encounter with GABA(B) receptors. Biochem Pharmacol. 2004 Oct 15; 68(8):1667-74. PMID: 15451410.
      View in: PubMed
    110. Tzingounis AV, Nicoll R. Presynaptic NMDA receptors get into the act. Nat Neurosci. 2004 May; 7(5):419-20. PMID: 15114348.
      View in: PubMed
    111. Fremeau RT, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Chaudhry FA, Nicoll R, Edwards RH. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004 Jun 18; 304(5678):1815-9. PMID: 15118123.
      View in: PubMed
    112. Tomita S, Fukata M, Nicoll R, Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science. 2004 Mar 05; 303(5663):1508-11. PMID: 15001777.
      View in: PubMed
    113. Moore KA, Nicoll R, Schmitz D. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14397-402. PMID: 14608033; PMCID: PMC283603.
    114. Dakoji S, Tomita S, Karimzadegan S, Nicoll R, Bredt DS. Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases. Neuropharmacology. 2003 Nov; 45(6):849-56. PMID: 14529722.
      View in: PubMed
    115. Bredt DS, Nicoll R. AMPA receptor trafficking at excitatory synapses. Neuron. 2003 Oct 09; 40(2):361-79. PMID: 14556714.
      View in: PubMed
    116. Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll R. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Mol Pharmacol. 2003 Sep; 64(3):703-6. PMID: 12920207.
      View in: PubMed
    117. Schmitz D, Mellor J, Breustedt J, Nicoll R. Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci. 2003 Oct; 6(10):1058-63. PMID: 12947409.
      View in: PubMed
    118. Rouach N, Nicoll R. Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus. Eur J Neurosci. 2003 Aug; 18(4):1017-20. PMID: 12925027.
      View in: PubMed
    119. Stein V, House DR, Bredt DS, Nicoll R. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J Neurosci. 2003 Jul 02; 23(13):5503-6. PMID: 12843250.
      View in: PubMed
    120. Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll R, Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol. 2003 May 26; 161(4):805-16. PMID: 12771129; PMCID: PMC2199354.
    121. Nicoll R. Expression mechanisms underlying long-term potentiation: a postsynaptic view. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29; 358(1432):721-6. PMID: 12740118; PMCID: PMC1693172.
    122. Stein V, Nicoll R. GABA generates excitement. Neuron. 2003 Feb 06; 37(3):375-8. PMID: 12575946.
      View in: PubMed
    123. Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll R. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13902-7. PMID: 12359873; PMCID: PMC129795.
    124. Klöcker N, Bunn RC, Schnell E, Caruana G, Bernstein A, Nicoll R, Bredt DS. Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. Eur J Neurosci. 2002 Oct; 16(8):1517-22. PMID: 12405965.
      View in: PubMed
    125. Chetkovich DM, Chen L, Stocker TJ, Nicoll R, Bredt DS. Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. J Neurosci. 2002 Jul 15; 22(14):5791-6. PMID: 12122038.
      View in: PubMed
    126. Wilson RI, Nicoll R. Endocannabinoid signaling in the brain. Science. 2002 Apr 26; 296(5568):678-82. PMID: 11976437.
      View in: PubMed
    127. El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll R, Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 2002 Mar 22; 108(6):849-63. PMID: 11955437.
      View in: PubMed
    128. Mellor J, Nicoll R, Schmitz D. Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science. 2002 Jan 04; 295(5552):143-7. PMID: 11778053.
      View in: PubMed
    129. Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH. Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci. 2002 Jan 01; 22(1):62-72. PMID: 11756489.
      View in: PubMed
    130. Nicoll R. Recurrent excitation of secondary olfactory neurons: a possible mechanism for signal amplification. Science. 1971 Feb 26; 171(3973):824-6. PMID: 5541166.
      View in: PubMed
    131. Barker JL, Crayton JW, Nicoll R. Supraoptic neurosecretory cells: adrenergic and cholinergic sensitivity. Science. 1971 Jan 15; 171(3967):208-10. PMID: 4395231.
      View in: PubMed