Leanne Jones, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #1323
San Francisco CA 94143
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    Collapse Education and Training
    Washington and Lee University , Lexington, VABSBiology
    Harvard University, Cambridge, MAPhDMicrobiology and Molecular Genetics

    Collapse Overview 

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    Collapse Research Activities and Funding
    Lipid mediated regulation of stem cell behavior and tissue homeostasis
    NIH R01GM135767Jun 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    Molecular mechanisms of a multi-tissue innate immune response
    NIH R01GM131094Aug 1, 2019 - May 31, 2023
    Role: Principal Investigator
    Regulation of intestinal stem cell behavior by occluding junctions
    NIH R01DK105442Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    New tools for investigating mitochondrial dynamics in stem cells during aging
    NIH R21AG052732Aug 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Metabolic regulation of stem cell behavior and longevity
    NIH R01AG040288Apr 1, 2012 - Apr 30, 2019
    Role: Principal Investigator
    Characterization of Age-Related Changes in Stem Cell Behavior
    NIH R01AG028092Apr 1, 2006 - May 31, 2020
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging. Cold Spring Harb Perspect Biol. 2021 09 01; 13(9). Rando TA, Jones DL. PMID: 34187808; PMCID: PMC8411956.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    2. Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor. Stem Cell Reports. 2021 06 08; 16(6):1584-1597. Resnik-Docampo M, Cunningham KM, Ruvalcaba SM, Choi C, Sauer V, Jones DL. PMID: 33961791; PMCID: PMC8190597.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    3. Lipid Mediated Regulation of Adult Stem Cell Behavior. Front Cell Dev Biol. 2020; 8:115. Clémot M, Sênos Demarco R, Jones DL. PMID: 32185173; PMCID: PMC7058546.
      View in: PubMed   Mentions: 31  
    4. EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis. Cell Rep. 2020 01 28; 30(4):1101-1116.e5. Sênos Demarco R, Uyemura BS, Jones DL. PMID: 31995752; PMCID: PMC7357864.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    5. Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. Sci Rep. 2019 12 23; 9(1):19695. Sênos Demarco R, Jones DL. PMID: 31873089; PMCID: PMC6927965.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    6. DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. Cell Mol Gastroenterol Hepatol. 2020; 9(3):527-541. Lewis SK, Nachun D, Martin MG, Horvath S, Coppola G, Jones DL. PMID: 31805439; PMCID: PMC7044532.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    7. Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis. Nat Cell Biol. 2019 06; 21(6):710-720. Sênos Demarco R, Uyemura BS, D'Alterio C, Jones DL. PMID: 31160709.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    8. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. J Cell Biol. 2017 08 07; 216(8):2315-2327. Koehler CL, Perkins GA, Ellisman MH, Jones DL. PMID: 28663346; PMCID: PMC5551703.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    9. Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nat Cell Biol. 2017 Jan; 19(1):52-59. Resnik-Docampo M, Koehler CL, Clark RI, Schinaman JM, Sauer V, Wong DM, Lewis S, D'Alterio C, Walker DW, Jones DL. PMID: 27992405; PMCID: PMC6336109.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    10. Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO J. 2014 Dec 17; 33(24):2983-96. Loza-Coll MA, Southall TD, Sandall SL, Brand AH, Jones DL. PMID: 25433031; PMCID: PMC4282644.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    11. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Rep. 2014 May 08; 7(3):722-34. Voog J, Sandall SL, Hime GR, Resende LP, Loza-Coll M, Aslanian A, Yates JR, Hunter T, Fuller MT, Jones DL. PMID: 24794442; PMCID: PMC4128242.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    12. Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster. Cell Rep. 2014 May 08; 7(3):859-70. Landais S, D'Alterio C, Jones DL. PMID: 24746823; PMCID: PMC4048808.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Headcase promotes cell survival and niche maintenance in the Drosophila testis. PLoS One. 2013; 8(7):e68026. Resende LP, Boyle M, Tran D, Fellner T, Jones DL. PMID: 23874487; PMCID: PMC3706621.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature. 2012 May 23; 485(7400):605-10. Toledano H, D'Alterio C, Czech B, Levine E, Jones DL. PMID: 22660319; PMCID: PMC4829122.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    15. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011 Nov 02; 14(5):623-34. Rera M, Bahadorani S, Cho J, Koehler CL, Ulgherait M, Hur JH, Ansari WS, Lo T, Jones DL, Walker DW. PMID: 22055505; PMCID: PMC3238792.
      View in: PubMed   Mentions: 224     Fields:    Translation:AnimalsCells
    16. Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle. 2011 Aug 15; 10(16):2628-34. Wang L, McLeod CJ, Jones DL. PMID: 21814033; PMCID: PMC3219535.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. Emerging models and paradigms for stem cell ageing. Nat Cell Biol. 2011 May; 13(5):506-12. Jones DL, Rando TA. PMID: 21540846; PMCID: PMC3257978.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    18. Metabolic regulation of stem cell behavior and implications for aging. Cell Metab. 2010 Dec 01; 12(6):561-5. Jasper H, Jones DL. PMID: 21109189; PMCID: PMC3012644.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    19. Stem cell dynamics in response to nutrient availability. Curr Biol. 2010 Dec 07; 20(23):2100-5. McLeod CJ, Wang L, Wong C, Jones DL. PMID: 21055942; PMCID: PMC3005562.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    20. Dietary restriction enhances germline stem cell maintenance. Aging Cell. 2010 Oct; 9(5):916-8. Mair W, McLeod CJ, Wang L, Jones DL. PMID: 20569233; PMCID: PMC2944899.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    21. Stem cells and the niche: a dynamic duo. Cell Stem Cell. 2010 Feb 05; 6(2):103-15. Voog J, Jones DL. PMID: 20144784; PMCID: PMC3012646.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    22. Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature. 2008 Aug 28; 454(7208):1132-6. Voog J, D'Alterio C, Jones DL. PMID: 18641633; PMCID: PMC2599791.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    23. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol. 2008 Jan; 9(1):11-21. Jones DL, Wagers AJ. PMID: 18097443.
      View in: PubMed   Mentions: 294     Fields:    Translation:HumansAnimalsCells
    24. Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell. 2007 Oct 11; 1(4):470-8. Boyle M, Wong C, Rocha M, Jones DL. PMID: 18371382.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    25. Aging and the germ line: where mortality and immortality meet. Stem Cell Rev. 2007; 3(3):192-200. Jones DL. PMID: 17917132.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science. 2003 Sep 12; 301(5639):1547-50. Yamashita YM, Jones DL, Fuller MT. PMID: 12970569.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
    27. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science. 2001 Dec 21; 294(5551):2542-5. Kiger AA, Jones DL, Schulz C, Rogers MB, Fuller MT. PMID: 11752574.
      View in: PubMed   Mentions: 274     Fields:    Translation:AnimalsCells
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