Deborah Dean, MD, MPH

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address5700 Martin Luther King Jr Way, #1415
Oakland CA 94609
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    Collapse Biography 
    Collapse Education and Training
    University of California Berkeley, Berkeley, CAB.S./B.A.1977Environmental Sciences/Philosophy
    Albert Einstein College of Medicine, The Bronx, NYMD1982Medicine
    University of California San Francisco School of Medicine, San Francisco, CAInternship & Residency1985Straight Internal Medicine
    University of California Berkeley School of Public Health, Berkeley, CAMPH1986Epidemiology & Biostatistics
    Stanford University School of Medicine, Palo Alto, CAPostdoctoral Fellow1991Microbial Pathogenesis
    Stanford University School of Medicine, Palo Alto, CAClinical Fellow1989Infectious Diseases
    University of California San Francisco School of Medicine, San Francisco, CA2021UCSF Diversity, Equity and Inclusion Champion
    University of California, San Francisco 2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    University of California Berkeley1985University of California Regents Scholar
    Stanford University School of Medicine1988McCormick Fund Award for Research Excellence
    Giannini Foundation, San Francisco, CA1989Giannini Foundation Fellowship
    National Institutes of Health1990Physician Scientist Award
    University of California San Francisco, School of Medicine1995Faculty Development Award
    World Health Organization, Geneva, Switzerland1999Member, Global Alliance to Eliminate Blinding Trachoma
    University of California Berkeley, School of Public Health2003Award for excellence in mentoring graduate students
    Apple Inc., Cupertino, CA2004Apple Cluster Workgroup for Bioinformatics Award
    Children's Hospital Oakland Research Institute2006Scientific Achievement Award for the most outstanding research
    United Nations2009United Nations Global Citizen Award
    NIH Minority Summer Student Research Program2016Outstanding Mentorship Award, 16 years of service
    University of California Berkeley, School of Public Health2018Influential Alumni Award for Significant Contributions in the Field of Public Health
    American Academy of Microbiology, Washington, D.C.2019Fellow, American Academy of Microbiology
    University of California San Francisco School of Medicine, Benioff Children's Hospitals2020Scientific Career Achievement Award
    Public Library of Science2023Award for service and commitment as an Editorial Board Member

    Collapse Overview 
    Collapse Overview
    Professor Dean’s research involves in vitro and bioinformatic approaches along with studies of human populations to address host-pathogen interactions, including bacterial genomics, host immune responses and microbiota/microbiome/metabolome associations with disease protection and pathogenesis related to the obligate intracellular bacterium Chlamydia trachomatis. Her group was the first to identify genomic recombination in this human pathogen. The Dean lab also studies the evolution of zoonotic chlamydial species. Professor Dean’s international research focusses on trachoma and sexually transmitted disease populations in Nepal, India, Ecuador, Thailand, Vietnam and Fiji. In addition, her group collaborates with Bay Area biotech start-ups to develop vaccines and rapid inexpensive point-of-care diagnostics for C. trachomatis and Neisseria gonorrhoeae for global deployment. She has a track record of 33 years of uninterrupted funding from the National Institutes of Health in addition to grants from the U.S. Centers for Disease Control, World Health Organization and the National Science Foundation. She has also mentored over 170 national and international undergraduate, graduate and medical students, and postdoctoral fellows who have gone on to university professorships and positions at institutes of health and centers for disease control throughout the world. Professor Dean remains an advocate for ocular and reproductive health among vulnerable and neglected populations worldwide.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of ocular microbiome, immune response and Chlamydiae on trachoma following MDA
    NIH/NIAID R01AI158527Jun 15, 2022 - Jun 30, 2027
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-Care Test for Chlamydia and Gonorrhea
    NIH R44AI152737Apr 22, 2020 - Mar 31, 2023
    Role: Principal Investigator
    Natural History of C. trachomatis urogenital and rectal infections
    NIH R01AI151075Mar 20, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Prevalence, incidence and risk factors for urogenital and rectal C. trachomatis and N. gonorrhoeae infections and antibiotic resistance in Fiji
    UCSF Bixby Center for Reproductive Health No NumberJan 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    C. trachomatis within-host genomic diversity and transmission between female anatomic sites
    NIH/NIAID R21AI138079Feb 25, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Rapid Assays to Detect Neisseria gonorrhea Antibiotic Resistance
    Centers for Disease Control and Prevention (CDC) CDC 200-2017-96231Sep 30, 2017 - Sep 30, 2020
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-Care Diagnostic for Neisseria gonorrhoeae
    NIH/NIAID R44AI129031Jan 25, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Low-Cost, Instrument-free Point of Care (POC) Platform for Infectious Disease Diagnostics
    National Science Foundation IIP-1449079Jan 1, 2015 - Jul 30, 2016
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-care Platform for Multiplexed Chlamydia Diagnostics
    NIH/NIAID R44AI114068Jul 15, 2014 - Jun 30, 2020
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-care Platform for Multiplexed Chlamydia Diagnos
    NIH R41AI114068Jul 15, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    Evaluation of trachoma status post MDA and validation of tools for monitoring trachoma in South East Asia
    Centers for Disease Control and Prevention (CDC) CDC 000HCWHCSep 1, 2013 - Aug 30, 2023
    Role: Principal Investigator
    Multiplex diagnostic for biothreat C. psittaci & non-threat respiratory pathogens
    NIH R01AI098843Jun 6, 2012 - May 31, 2019
    Role: Principal Investigator
    A novel vaccine against vaginal Chlamydia trachomatis
    NIH R41AI096706Jun 5, 2012 - May 31, 2015
    Role: Co-Principal Investigator
    A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    NIH R43AI096768Jul 5, 2011 - Jun 30, 2013
    Role: Co-Principal Investigator
    The influence of negative regulators of inflammation on C. trachomatis infections
    NIH R56AI078419Sep 9, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Genome sequencing and evolution of Chlamydophila and Chlamydia species of animal origin
    National Science Foundation 2009-65109-05760Sep 15, 2009 - Sep 14, 2016
    Role: Principal Investigator
    A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    NIH R44AI084206Jul 15, 2009 - Feb 29, 2016
    Role: Co-Principal Investigator
    A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    NIH R43AI084206Jul 15, 2009 - Mar 14, 2012
    Role: Principal Investigator
    Pathogenesis of persistent C. trachomatis STDs
    NIH R03TW007754Jan 1, 2008 - Dec 31, 2010
    Role: Principal Investigator
    C. trachomatis genomics, strain typing, and evolution
    NIH R01AI059647Apr 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    NIH R01EY012219May 1, 2000 - Apr 30, 2006
    Role: Principal Investigator
    Pathogenesis of Persistent Chlamydial STDs
    NIH R01AI039499Jun 1, 1997 - Dec 31, 2008
    Role: Principal Investigator
    CHLAMYDIA OCULAR INFECTIONS--MOLECULAR EPIDEMIOLOGY
    NIH K11EY000310Dec 1, 1990 - Nov 30, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chlamydia suis undergoes interclade recombination promoting Tet-island exchange. BMC Genomics. 2024 Jul 26; 25(1):724. Seth-Smith H, Bommana S, Dean D, Read TD, Marti H. PMID: 39060998; PMCID: PMC11282597.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Corrigendum: Patterns of within-host spread of Chlamydia trachomatis between vagina, endocervix and rectum revealed by comparative genomic analysis. Front Microbiol. 2024; 15:1441327. Joseph SJ, Bommana S, Ziklo N, Kama M, Dean D, Read TD. PMID: 38983628; PMCID: PMC11231733.
      View in: PubMed   Mentions:
    3. Unique microbial diversity, community composition, and networks among Pacific Islander endocervical and vaginal microbiomes with and without Chlamydia trachomatis infection in Fiji. mBio. 2024 Jan 16; 15(1):e0306323. Bommana S, Hu Y-J, Kama M, Wang R, Kodimerla R, Jijakli K, Read TD, Dean D. PMID: 38117091; PMCID: PMC10790706.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae. New Microbes New Infect. 2023 Sep; 54:101158. Greub G, Pillonel T, Bavoil PM, Borel N, Campbell LA, Dean D, Hefty S, Horn M, Morré SA, Ouellette SP, Pannekoek Y, Puolakkainen M, Timms P, Valdivia R, Vanrompay D. PMID: 37416863; PMCID: PMC10320375.
      View in: PubMed   Mentions: 2  
    5. Patterns of within-host spread of Chlamydia trachomatis between vagina, endocervix and rectum revealed by comparative genomic analysis. Front Microbiol. 2023; 14:1154664. Joseph SJ, Bommana S, Ziklo N, Kama M, Dean D, Read TD. PMID: 37056744; PMCID: PMC10086254.
      View in: PubMed   Mentions: 1  
    6. Chlamydial and gonorrheal neglected sexually transmitted diseases among Pacific Islanders of the Western Pacific Region-A narrative review and call to action. PLoS Negl Trop Dis. 2023 03; 17(3):e0011171. Auchus IC, Kama M, Bhuiyan RA, Brown J, Dean D. PMID: 36928890; PMCID: PMC10019716.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Patterns of within-host spread of Chlamydia trachomatis between vagina, endocervix and rectum revealed by comparative genomic analysis. bioRxiv. 2023 Jan 26. Joseph SJ, Bommana S, Ziklo N, Kama M, Dean D, Read TD. PMID: 36747780; PMCID: PMC9901013.
      View in: PubMed   Mentions:
    8. Multiplex recombinase polymerase amplification for high-risk and low-risk type HPV detection, as potential local use in single tube. Sci Rep. 2023 01 16; 13(1):829. Wongsamart R, Bhattarakasol P, Chaiwongkot A, Wongsawaeng D, Okada PA, Palaga T, Leelahavanichkul A, Khovidhunkit W, Dean D, Somboonna N. PMID: 36646782; PMCID: PMC9841928.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Metagenomic Shotgun Sequencing of Endocervical, Vaginal, and Rectal Samples among Fijian Women with and without Chlamydia trachomatis Reveals Disparate Microbial Populations and Function across Anatomic Sites: a Pilot Study. Microbiol Spectr. 2022 06 29; 10(3):e0010522. Bommana S, Richards G, Kama M, Kodimerla R, Jijakli K, Read TD, Dean D. PMID: 35579443; PMCID: PMC9241848.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. Generation of Tetracycline and Rifamycin Resistant Chlamydia Suis Recombinants. Front Microbiol. 2021; 12:630293. Marti H, Bommana S, Read TD, Pesch T, Prähauser B, Dean D, Borel N. PMID: 34276577; PMCID: PMC8278220.
      View in: PubMed   Mentions: 2  
    11. Development and Evaluation of a Point-of-Care Test in a Low-Resource Setting with High Rates of Chlamydia trachomatis Urogenital Infections in Fiji. J Clin Microbiol. 2021 06 18; 59(7):e0018221. Dean D, Swaminathan S, Kama M, Goemans S, Faktaufon D, Alnabelseya N, Spelke D, Kahrizi K, Black M, Mitra D. PMID: 33910964; PMCID: PMC8218753.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function. mBio. 2021 05 11; 12(3). Bommana S, Somboonna N, Richards G, Tarazkar M, Dean D. PMID: 33975934; PMCID: PMC8262981.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Whole-Genome Enrichment and Sequencing of Chlamydia trachomatis Directly from Patient Clinical Vaginal and Rectal Swabs. mSphere. 2021 03 03; 6(2). Bowden KE, Joseph SJ, Cartee JC, Ziklo N, Danavall D, Raphael BH, Read TD, Dean D. PMID: 33658279; PMCID: PMC8546720.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant Staphylococcus aureus (MRSA). ACS Sens. 2021 03 26; 6(3):742-751. Choopara I, Suea-Ngam A, Teethaisong Y, Howes PD, Schmelcher M, Leelahavanichkul A, Thunyaharn S, Wongsawaeng D, deMello AJ, Dean D, Somboonna N. PMID: 33439634.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Chlamydia trachomatis L2c Infection in a Porcine Model Produced Urogenital Pathology and Failed to Induce Protective Immune Responses Against Re-Infection. Front Immunol. 2020; 11:555305. De Clercq E, Van Gils M, Schautteet K, Devriendt B, Kiekens C, Chiers K, Van Den Broeck W, Cox E, Dean D, Vanrompay D. PMID: 33193323; PMCID: PMC7649141.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Rapid colorimetric loop-mediated isothermal amplification for hypersensitive point-of-care Staphylococcus aureus enterotoxin A gene detection in milk and pork products. Sci Rep. 2020 05 08; 10(1):7768. Srimongkol G, Ditmangklo B, Choopara I, Thaniyavarn J, Dean D, Kokpol S, Vilaivan T, Somboonna N. PMID: 32385390; PMCID: PMC7211006.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji. PLoS Negl Trop Dis. 2020 01; 14(1):e0008022. Svigals V, Blair A, Muller S, Sahu Khan A, Faktaufon D, Kama M, Tamani T, Esfandiari L, O'Brien M, Dean D. PMID: 31971951; PMCID: PMC6999915.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    18. Reply to Rockey et al., "Genomics and Chlamydial Persistence In Vivo". mBio. 2019 12 17; 10(6). Dean D, Ziklo N, Somboonna N, Suh JH, Ferrin T. PMID: 31848290; PMCID: PMC6918091.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    19. Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon. mBio. 2019 07 16; 10(4). Somboonna N, Ziklo N, Ferrin TE, Hyuk Suh J, Dean D. PMID: 31311884; PMCID: PMC6635532.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Stromal Fibroblasts Drive Host Inflammatory Responses That Are Dependent on Chlamydia trachomatis Strain Type and Likely Influence Disease Outcomes. mBio. 2019 03 19; 10(2). Jolly AL, Rau S, Chadha AK, Abdulraheem EA, Dean D. PMID: 30890604; PMCID: PMC6426598.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. The utility of serology for elimination surveillance of trachoma. Nat Commun. 2018 12 21; 9(1):5444. Pinsent A, Solomon AW, Bailey RL, Bid R, Cama A, Dean D, Goodhew B, Gwyn SE, Jack KR, Kandel RP, Kama M, Massae P, Macleod C, Mabey DCW, Migchelsen S, Müller A, Sandi F, Sokana O, Taoaba R, Tekeraoi R, Martin DL, White MT. PMID: 30575720; PMCID: PMC6303365.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCellsPHPublic Health
    22. Rapid and sensitive detection of Chlamydia trachomatis sexually transmitted infections in resource-constrained settings in Thailand at the point-of-care. PLoS Negl Trop Dis. 2018 12; 12(12):e0006900. Somboonna N, Choopara I, Arunrut N, Sukhonpan K, Sayasathid J, Dean D, Kiatpathomchai W. PMID: 30571705; PMCID: PMC6301561.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. Evaluating the Antibiotic Susceptibility of Chlamydia - New Approaches for in Vitro Assays. Front Microbiol. 2018; 9:1414. Marti H, Borel N, Dean D, Leonard CA. PMID: 30018602; PMCID: PMC6037721.
      View in: PubMed   Mentions: 5  
    24. Prevalence of Chlamydia trachomatis-Specific Antibodies before and after Mass Drug Administration for Trachoma in Community-Wide Surveys of Four Communities in Nepal. Am J Trop Med Hyg. 2018 01; 98(1):216-220. Gwyn SE, Xiang L, Kandel RP, Dean D, Gambhir M, Martin DL. PMID: 29141720; PMCID: PMC5928690.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    25. Chlamydia trachomatis regulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets. Cell Microbiol. 2018 02; 20(2). Sharma M, Recuero-Checa MA, Fan FY, Dean D. PMID: 29117636; PMCID: PMC5764794.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Chlamydia trachomatis Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides. Front Microbiol. 2017; 8:2195. Smelov V, Vrbanac A, van Ess EF, Noz MP, Wan R, Eklund C, Morgan T, Shrier LA, Sanders B, Dillner J, de Vries HJC, Morre SA, Dean D. PMID: 29180986; PMCID: PMC5693916.
      View in: PubMed   Mentions: 12  
    27. Correction: Comprehensive bioinformatics analysis of Mycoplasma pneumoniae genomes to investigate underlying population structure and type-specific determinants. PLoS One. 2017; 12(10):e0186030. Diaz MH, Desai HP, Morrison SS, Benitez AJ, Wolff BJ, Caravas J, Read TD, Dean D, Winchell JM. PMID: 28977025; PMCID: PMC5627953.
      View in: PubMed   Mentions: 1     Fields:    
    28. Rapid detection and strain typing of Chlamydia trachomatis using a highly multiplexed microfluidic PCR assay. PLoS One. 2017; 12(5):e0178653. Turingan RS, Kaplun L, Krautz-Peterson G, Norsworthy S, Zolotova A, Joseph SJ, Read TD, Dean D, Tan E, Selden RF. PMID: 28562672; PMCID: PMC5451082.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    29. Comprehensive bioinformatics analysis of Mycoplasma pneumoniae genomes to investigate underlying population structure and type-specific determinants. PLoS One. 2017; 12(4):e0174701. Diaz MH, Desai HP, Morrison SS, Benitez AJ, Wolff BJ, Caravas J, Read TD, Dean D, Winchell JM. PMID: 28410368; PMCID: PMC5391922.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    30. Tet(C) Gene Transfer between Chlamydia suis Strains Occurs by Homologous Recombination after Co-infection: Implications for Spread of Tetracycline-Resistance among Chlamydiaceae. Front Microbiol. 2017; 8:156. Marti H, Kim H, Joseph SJ, Dojiri S, Read TD, Dean D. PMID: 28223970; PMCID: PMC5293829.
      View in: PubMed   Mentions: 18  
    31. Dynamics of genome change among Legionella species. Sci Rep. 2016 09 16; 6:33442. Joseph SJ, Cox D, Wolff B, Morrison SS, Kozak-Muiznieks NA, Frace M, Didelot X, Castillo-Ramirez S, Winchell J, Read TD, Dean D. PMID: 27633769; PMCID: PMC5025774.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    32. Tetracycline Selective Pressure and Homologous Recombination Shape the Evolution of Chlamydia suis: A Recently Identified Zoonotic Pathogen. Genome Biol Evol. 2016 09 02; 8(8):2613-23. Joseph SJ, Marti H, Didelot X, Read TD, Dean D. PMID: 27576537; PMCID: PMC5010913.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    33. Lateral flow-based antibody testing for Chlamydia trachomatis. J Immunol Methods. 2016 08; 435:27-31. Gwyn S, Mitchell A, Dean D, Mkocha H, Handali S, Martin DL. PMID: 27208400.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs). Sci Rep. 2016 Mar 18; 6:23148. Recuero-Checa MA, Sharma M, Lau C, Watkins PA, Gaydos CA, Dean D. PMID: 26988341; PMCID: PMC4796813.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    35. A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Cell Rep. 2016 Jan 26; 14(3):611-620. Jolly AL, Luan CH, Dusel BE, Dunne SF, Winding M, Dixit VJ, Robins C, Saluk JL, Logan DJ, Carpenter AE, Sharma M, Dean D, Cohen AR, Gelfand VI. PMID: 26774481; PMCID: PMC4868501.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Chlamydiaceae Genomics Reveals Interspecies Admixture and the Recent Evolution of Chlamydia abortus Infecting Lower Mammalian Species and Humans. Genome Biol Evol. 2015 Oct 27; 7(11):3070-84. Joseph SJ, Marti H, Didelot X, Castillo-Ramirez S, Read TD, Dean D. PMID: 26507799; PMCID: PMC4994753.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance. PeerJ. 2015; 3:e806. Ezewudo MN, Joseph SJ, Castillo-Ramirez S, Dean D, Del Rio C, Didelot X, Dillon JA, Selden RF, Shafer WM, Turingan RS, Unemo M, Read TD. PMID: 25780762; PMCID: PMC4358642.
      View in: PubMed   Mentions: 48     Fields:    
    38. Novel Chlamydia trachomatis strains in heterosexual sex partners, Indianapolis, Indiana, USA. Emerg Infect Dis. 2014 Nov; 20(11):1841-7. Batteiger BE, Wan R, Williams JA, He L, Ma A, Fortenberry JD, Dean D. PMID: 25340463; PMCID: PMC4214310.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Direct amplification, sequencing and profiling of Chlamydia trachomatis strains in single and mixed infection clinical samples. PLoS One. 2014; 9(6):e99290. Joseph SJ, Li B, Ghonasgi T, Haase CP, Qin ZS, Dean D, Read TD. PMID: 24971628; PMCID: PMC4074039.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    40. TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans. PLoS One. 2014; 9(4):e93939. Al-Kuhlani M, Rothschild J, Rothchild J, Pal S, de la Maza LM, Ouburg S, Morré SA, Dean D, Ojcius DM. PMID: 24695582; PMCID: PMC3973638.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Zoonotic Chlamydiaceae species associated with trachoma, Nepal. Emerg Infect Dis. 2013 Dec; 19(12):1948-55. Dean D, Rothschild J, Ruettger A, Kandel RP, Sachse K. PMID: 24274654; PMCID: PMC3840858.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    42. Comparative analysis of Chlamydia psittaci genomes reveals the recent emergence of a pathogenic lineage with a broad host range. mBio. 2013 Mar 26; 4(2). Read TD, Joseph SJ, Didelot X, Liang B, Patel L, Dean D. PMID: 23532978; PMCID: PMC3622922.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    43. Analyzing microsatellites using the QIAxcel system. Methods Mol Biol. 2013; 1006:223-43. Dean DA, Wadl PA, Hadziabdic D, Wang X, Trigiano RN. PMID: 23546795.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    44. Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell Microbiol. 2013 May; 15(5):779-94. Wang A, Al-Kuhlani M, Johnston SC, Ojcius DM, Chou J, Dean D. PMID: 23163821; PMCID: PMC3593943.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    45. A multiplexed microfluidic PCR assay for sensitive and specific point-of-care detection of Chlamydia trachomatis. PLoS One. 2012; 7(12):e51685. Dean D, Turingan RS, Thomann HU, Zolotova A, Rothschild J, Joseph SJ, Read TD, Tan E, Selden RF. PMID: 23272140; PMCID: PMC3522697.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. Population genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure. Mol Biol Evol. 2012 Dec; 29(12):3933-46. Joseph SJ, Didelot X, Rothschild J, de Vries HJ, Morré SA, Read TD, Dean D. PMID: 22891032; PMCID: PMC3494276.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    47. Eukaryotic protein recruitment into the Chlamydia inclusion: implications for survival and growth. PLoS One. 2012; 7(5):e36843. Soupene E, Rothschild J, Kuypers FA, Dean D. PMID: 22590624; PMCID: PMC3348897.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    48. Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection. Biomaterials. 2012 Jul; 33(20):5166-74. Bhattarai SR, Yoo SY, Lee SW, Dean D. PMID: 22494890; PMCID: PMC3341514.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    49. Ten polymorphic microsatellite loci identified from a small insert genomic library for Peronospora tabacina. Mycologia. 2012 May-Jun; 104(3):633-40. Trigiano RN, Wadl PA, Dean D, Hadziabdic D, Scheffler BE, Runge F, Telle S, Thines M, Ristaino J, Spring O. PMID: 22241615.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    50. In vitro recombinants of antibiotic-resistant Chlamydia trachomatis strains have statistically more breakpoints than clinical recombinants for the same sequenced loci and exhibit selection at unexpected loci. J Bacteriol. 2012 Feb; 194(3):617-26. Srinivasan T, Bruno WJ, Wan R, Yen A, Duong J, Dean D. PMID: 22123249; PMCID: PMC3264063.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    51. Interplay of recombination and selection in the genomes of Chlamydia trachomatis. Biol Direct. 2011 May 26; 6:28. Joseph SJ, Didelot X, Gandhi K, Dean D, Read TD. PMID: 21615910; PMCID: PMC3126793.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    52. Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. mBio. 2011; 2(3):e00045-11. Somboonna N, Wan R, Ojcius DM, Pettengill MA, Joseph SJ, Chang A, Hsu R, Read TD, Dean D. PMID: 21540364; PMCID: PMC3088116.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    53. Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke. PLoS One. 2010 Jun 09; 5(6):e11026. Atik B, Johnston SC, Dean D. PMID: 20543948; PMCID: PMC2882946.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    54. Characterization of humoral immune responses to chlamydial HSP60, CPAF, and CT795 in inflammatory and severe trachoma. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5128-36. Skwor T, Kandel RP, Basravi S, Khan A, Sharma B, Dean D. PMID: 20463311; PMCID: PMC3066612.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. A systemic network for Chlamydia pneumoniae entry into human cells. J Bacteriol. 2010 Jun; 192(11):2809-15. Wang A, Johnston SC, Chou J, Dean D. PMID: 20233927; PMCID: PMC2876499.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    56. Predicting phenotype and emerging strains among Chlamydia trachomatis infections. Emerg Infect Dis. 2009 Sep; 15(9):1385-94. Dean D, Bruno WJ, Wan R, Gomes JP, Devignot S, Mehari T, de Vries HJ, Morré SA, Myers G, Read TD, Spratt BG. PMID: 19788805; PMCID: PMC2819883.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    57. Chlamydia trachomatis-infected patients display variable antibody profiles against the nine-member polymorphic membrane protein family. Infect Immun. 2009 Aug; 77(8):3218-26. Tan C, Hsia RC, Shou H, Haggerty CL, Ness RB, Gaydos CA, Dean D, Scurlock AM, Wilson DP, Bavoil PM. PMID: 19487469; PMCID: PMC2715660.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    58. Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis. PLoS One. 2008; 3(10):e3600. Atik B, Skwor TA, Kandel RP, Sharma B, Adhikari HK, Steiner L, Erlich H, Dean D. PMID: 18974840; PMCID: PMC2572999.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    59. Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e264. Skwor TA, Atik B, Kandel RP, Adhikari HK, Sharma B, Dean D. PMID: 18628987; PMCID: PMC2442224.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    60. Discovering and differentiating new and emerging clonal populations of Chlamydia trachomatis with a novel shotgun cell culture harvest assay. Emerg Infect Dis. 2008 Mar; 14(3):445-53. Somboonna N, Mead S, Liu J, Dean D. PMID: 18325260; PMCID: PMC2570839.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    61. Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control. PLoS Med. 2008 Jan 03; 5(1):e14. Dean D, Kandel RP, Adhikari HK, Hessel T. PMID: 18177205; PMCID: PMC2174965.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsPHPublic Health
    62. Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains. PLoS One. 2007 Sep 12; 2(9):e878. Nunes A, Gomes JP, Mead S, Florindo C, Correia H, Borrego MJ, Dean D. PMID: 17849007; PMCID: PMC1963315.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    63. Evaluating the "A" component of the SAFE strategy. Lancet Infect Dis. 2007 Jan; 7(1):2-3. Dean D, Atik B, Ton TK, Vu QL, Lagree S. PMID: 17182334.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    64. Genomic plasticity of the rrn-nqrF intergenic segment in the Chlamydiaceae. J Bacteriol. 2007 Mar; 189(5):2128-32. Liu Z, Rank R, Kaltenboeck B, Magnino S, Dean D, Burall L, Plaut RD, Read TD, Myers G, Bavoil PM. PMID: 17158668; PMCID: PMC1855709.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    65. Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots. Genome Res. 2007 Jan; 17(1):50-60. Gomes JP, Bruno WJ, Nunes A, Santos N, Florindo C, Borrego MJ, Dean D. PMID: 17090662; PMCID: PMC1716266.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    66. Impact of annual targeted treatment on infectious trachoma and susceptibility to reinfection. JAMA. 2006 Sep 27; 296(12):1488-97. Atik B, Thanh TT, Luong VQ, Lagree S, Dean D. PMID: 17003397.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    67. Population-based genetic epidemiologic analysis of Chlamydia trachomatis serotypes and lack of association between ompA polymorphisms and clinical phenotypes. Microbes Infect. 2006 Mar; 8(3):604-11. Millman K, Black CM, Stamm WE, Jones RB, Hook EW, Martin DH, Bolan G, Tavaré S, Dean D. PMID: 16527508.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    68. Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: evidence for serovar Da recombination and correlation with tissue tropism. J Bacteriol. 2006 Jan; 188(1):275-86. Gomes JP, Nunes A, Bruno WJ, Borrego MJ, Florindo C, Dean D. PMID: 16352844; PMCID: PMC1317584.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    69. Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2648-53. Johnston SC, Zhang H, Messina LM, Lawton MT, Dean D. PMID: 16210572.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis. Microbes Infect. 2006 Jan; 8(1):16-26. Gomes JP, Borrego MJ, Atik B, Santo I, Azevedo J, Brito de Sá A, Nogueira P, Dean D. PMID: 16289001.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    71. Immunoreactivity and differential developmental expression of known and putative Chlamydia trachomatis membrane proteins for biologically variant serovars representing distinct disease groups. Microbes Infect. 2005 Mar; 7(3):410-20. Gomes JP, Hsia RC, Mead S, Borrego MJ, Dean D. PMID: 15784185.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    72. Recombination in the genome of Chlamydia trachomatis involving the polymorphic membrane protein C gene relative to ompA and evidence for horizontal gene transfer. J Bacteriol. 2004 Jul; 186(13):4295-306. Gomes JP, Bruno WJ, Borrego MJ, Dean D. PMID: 15205432; PMCID: PMC421610.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    73. Risk factors for recurrence of postoperative trichiasis: implications for trachoma blindness prevention. Arch Ophthalmol. 2004 Apr; 122(4):511-6. Zhang H, Kandel RP, Sharma B, Dean D. PMID: 15078668.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    74. Population-based genetic and evolutionary analysis of Chlamydia trachomatis urogenital strain variation in the United States. J Bacteriol. 2004 Apr; 186(8):2457-65. Millman K, Black CM, Johnson RE, Stamm WE, Jones RB, Hook EW, Martin DH, Bolan G, Tavaré S, Dean D. PMID: 15060049; PMCID: PMC412158.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    75. Limitations of screening tests for the detection of Chlamydia trachomatis in asymptomatic adolescent and young adult women. Am J Obstet Gynecol. 2004 Mar; 190(3):654-62. Shrier LA, Dean D, Klein E, Harter K, Rice PA. PMID: 15041995.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    76. Modeling the economic net benefit of a potential vaccination program against ocular infection with Chlamydia trachomatis. Vaccine. 2004 Jan 26; 22(5-6):689-96. Frick KD, Colchero MA, Dean D. PMID: 14741161.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    77. Chlamydia pneumoniae and acute chest syndrome in patients with sickle cell disease. J Pediatr Hematol Oncol. 2003 Jan; 25(1):46-55. Dean D, Neumayr L, Kelly DM, Ballas SK, Kleman K, Robertson S, Iyer RV, Ware RE, Koshy M, Rackoff WR, Pegelow CH, Waldron P, Benjamin L, Vichinsky E, Acute Chest Syndrome Study Group. PMID: 12544773.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
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