Deborah Dean, MD, MPH

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California Berkeley, Berkeley, CAB.S./B.A.1977Environmental Sciences/Philosophy
    Albert Einstein College of Medicine, The Bronx, NYMD1982Medicine
    University of California San Francisco School of Medicine, San Francisco, CAInternship & Residency1983Straight Internal Medicine
    University of California Berkeley School of Public Health, Berkeley, CAMPH1986Epidemiology & Biostatistics
    Stanford University School of Medicine, Palo Alto, CAPostdoctoral Fellow1991Microbial Pathogenesis
    Stanford University School of Medicine, Palo Alto, CAClinical Fellow1989Infectious Diseases

    Collapse Research 
    Collapse Research Activities and Funding
    Low-Cost Instrument-free Point-of-Care Test for Chlamydia and Gonorrhea
    NIH R44AI152737Apr 22, 2020 - Mar 31, 2023
    Role: Principal Investigator
    Natural History of C. trachomatis urogenital and rectal infections
    NIH R01AI151075Mar 20, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Prevalence, incidence and risk factors for urogenital and rectal C. trachomatis and N. gonorrhoeae infections and antibiotic resistance in Fiji
    UCSF Bixby Center for Reproductive Health No NumberJan 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    C. trachomatis within-host genomic diversity and transmission between female anatomic sites
    NIH/NIAID R21AI138079Feb 25, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Rapid Assays to Detect Neisseria gonorrhea Antibiotic Resistance
    Centers for Disease Control and Prevention (CDC) CDC 200-2017-96231Sep 30, 2017 - Sep 30, 2020
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-Care Diagnostic for Neisseria gonorrhoeae
    NIH/NIAID R44AI129031Jan 25, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Low-Cost, Instrument-free Point of Care (POC) Platform for Infectious Disease Diagnostics
    National Science Foundation IIP-1449079Jan 1, 2015 - Jul 30, 2016
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-care Platform for Multiplexed Chlamydia Diagnostics
    NIH/NIAID R44AI114068Jul 15, 2014 - Jun 30, 2020
    Role: Principal Investigator
    Low-Cost Instrument-free Point-of-care Platform for Multiplexed Chlamydia Diagnos
    NIH R41AI114068Jul 15, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    Evaluation of trachoma status post MDA and validation of tools for monitoring trachoma in South East Asia
    Centers for Disease Control and Prevention (CDC) CDC 000HCWHCSep 1, 2013 - Aug 30, 2023
    Role: Principal Investigator
    Multiplex diagnostic for biothreat C. psittaci & non-threat respiratory pathogens
    NIH R01AI098843Jun 6, 2012 - May 31, 2019
    Role: Principal Investigator
    A novel vaccine against vaginal Chlamydia trachomatis
    NIH R41AI096706Jun 5, 2012 - May 31, 2015
    Role: Co-Principal Investigator
    A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    NIH R43AI096768Jul 5, 2011 - Jun 30, 2013
    Role: Co-Principal Investigator
    The influence of negative regulators of inflammation on C. trachomatis infections
    NIH R56AI078419Sep 9, 2010 - Aug 31, 2012
    Role: Principal Investigator
    Genome sequencing and evolution of Chlamydophila and Chlamydia species of animal origin
    National Science Foundation 2009-65109-05760Sep 15, 2009 - Sep 14, 2016
    Role: Principal Investigator
    A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    NIH R44AI084206Jul 15, 2009 - Feb 29, 2016
    Role: Co-Principal Investigator
    A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    NIH R43AI084206Jul 15, 2009 - Mar 14, 2012
    Role: Principal Investigator
    Pathogenesis of persistent C. trachomatis STDs
    NIH R03TW007754Jan 1, 2008 - Dec 31, 2010
    Role: Principal Investigator
    C. trachomatis genomics, strain typing, and evolution
    NIH R01AI059647Apr 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    NIH R01EY012219May 1, 2000 - Apr 30, 2006
    Role: Principal Investigator
    Pathogenesis of Persistent Chlamydial STDs
    NIH R01AI039499Jun 1, 1997 - Dec 31, 2008
    Role: Principal Investigator
    CHLAMYDIA OCULAR INFECTIONS--MOLECULAR EPIDEMIOLOGY
    NIH K11EY000310Dec 1, 1990 - Nov 30, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function. mBio. 2021 05 11; 12(3). Bommana S, Somboonna N, Richards G, Tarazkar M, Dean D. PMID: 33975934.
      View in: PubMed   Mentions:    Fields:    
    2. Whole-Genome Enrichment and Sequencing of Chlamydia trachomatis Directly from Patient Clinical Vaginal and Rectal Swabs. mSphere. 2021 03 03; 6(2). Bowden KE, Joseph SJ, Cartee JC, Ziklo N, Danavall D, Raphael BH, Read TD, Dean D. PMID: 33658279.
      View in: PubMed   Mentions:    Fields:    
    3. Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant Staphylococcus aureus (MRSA). ACS Sens. 2021 03 26; 6(3):742-751. Choopara I, Suea-Ngam A, Teethaisong Y, Howes PD, Schmelcher M, Leelahavanichkul A, Thunyaharn S, Wongsawaeng D, deMello AJ, Dean D, Somboonna N. PMID: 33439634.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Rapid colorimetric loop-mediated isothermal amplification for hypersensitive point-of-care Staphylococcus aureus enterotoxin A gene detection in milk and pork products. Sci Rep. 2020 05 08; 10(1):7768. Srimongkol G, Ditmangklo B, Choopara I, Thaniyavarn J, Dean D, Kokpol S, Vilaivan T, Somboonna N. PMID: 32385390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji. PLoS Negl Trop Dis. 2020 01; 14(1):e0008022. Svigals V, Blair A, Muller S, Sahu Khan A, Faktaufon D, Kama M, Tamani T, Esfandiari L, O'Brien M, Dean D. PMID: 31971951.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    6. Reply to Rockey et al., "Genomics and Chlamydial Persistence In Vivo". mBio. 2019 12 17; 10(6). Dean D, Ziklo N, Somboonna N, Suh JH, Ferrin T. PMID: 31848290.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional aßßa Tetramer of the Tryptophan Synthase Operon. mBio. 2019 07 16; 10(4). Somboonna N, Ziklo N, Ferrin TE, Hyuk Suh J, Dean D. PMID: 31311884.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Stromal Fibroblasts Drive Host Inflammatory Responses That Are Dependent on Chlamydia trachomatis Strain Type and Likely Influence Disease Outcomes. mBio. 2019 03 19; 10(2). Jolly AL, Rau S, Chadha AK, Abdulraheem EA, Dean D. PMID: 30890604.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Rapid and sensitive detection of Chlamydia trachomatis sexually transmitted infections in resource-constrained settings in Thailand at the point-of-care. PLoS Negl Trop Dis. 2018 12; 12(12):e0006900. Somboonna N, Choopara I, Arunrut N, Sukhonpan K, Sayasathid J, Dean D, Kiatpathomchai W. PMID: 30571705.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Chlamydia trachomatis regulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets. Cell Microbiol. 2018 02; 20(2). Sharma M, Recuero-Checa MA, Fan FY, Dean D. PMID: 29117636.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Tet(C) Gene Transfer between Chlamydia suis Strains Occurs by Homologous Recombination after Co-infection: Implications for Spread of Tetracycline-Resistance among Chlamydiaceae. Front Microbiol. 2017; 8:156. Marti H, Kim H, Joseph SJ, Dojiri S, Read TD, Dean D. PMID: 28223970.
      View in: PubMed   Mentions:
    12. Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs). Sci Rep. 2016 Mar 18; 6:23148. Recuero-Checa MA, Sharma M, Lau C, Watkins PA, Gaydos CA, Dean D. PMID: 26988341.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Cell Rep. 2016 Jan 26; 14(3):611-620. Jolly AL, Luan CH, Dusel BE, Dunne SF, Winding M, Dixit VJ, Robins C, Saluk JL, Logan DJ, Carpenter AE, Sharma M, Dean D, Cohen AR, Gelfand VI. PMID: 26774481.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Comparative analysis of Chlamydia psittaci genomes reveals the recent emergence of a pathogenic lineage with a broad host range. mBio. 2013 Mar 26; 4(2). Read TD, Joseph SJ, Didelot X, Liang B, Patel L, Dean D. PMID: 23532978.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    15. Analyzing microsatellites using the QIAxcel system. Methods Mol Biol. 2013; 1006:223-43. Dean DA, Wadl PA, Hadziabdic D, Wang X, Trigiano RN. PMID: 23546795.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell Microbiol. 2013 May; 15(5):779-94. Wang A, Al-Kuhlani M, Johnston SC, Ojcius DM, Chou J, Dean D. PMID: 23163821.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    17. A multiplexed microfluidic PCR assay for sensitive and specific point-of-care detection of Chlamydia trachomatis. PLoS One. 2012; 7(12):e51685. Dean D, Turingan RS, Thomann HU, Zolotova A, Rothschild J, Joseph SJ, Read TD, Tan E, Selden RF. PMID: 23272140.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Eukaryotic protein recruitment into the Chlamydia inclusion: implications for survival and growth. PLoS One. 2012; 7(5):e36843. Soupene E, Rothschild J, Kuypers FA, Dean D. PMID: 22590624.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection. Biomaterials. 2012 Jul; 33(20):5166-74. Bhattarai SR, Yoo SY, Lee SW, Dean D. PMID: 22494890.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    20. Ten polymorphic microsatellite loci identified from a small insert genomic library for Peronospora tabacina. Mycologia. 2012 May-Jun; 104(3):633-40. Trigiano RN, Wadl PA, Dean D, Hadziabdic D, Scheffler BE, Runge F, Telle S, Thines M, Ristaino J, Spring O. PMID: 22241615.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. In vitro recombinants of antibiotic-resistant Chlamydia trachomatis strains have statistically more breakpoints than clinical recombinants for the same sequenced loci and exhibit selection at unexpected loci. J Bacteriol. 2012 Feb; 194(3):617-26. Srinivasan T, Bruno WJ, Wan R, Yen A, Duong J, Dean D. PMID: 22123249.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. mBio. 2011; 2(3):e00045-11. Somboonna N, Wan R, Ojcius DM, Pettengill MA, Joseph SJ, Chang A, Hsu R, Read TD, Dean D. PMID: 21540364.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    23. Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke. PLoS One. 2010 Jun 09; 5(6):e11026. Atik B, Johnston SC, Dean D. PMID: 20543948.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. Characterization of humoral immune responses to chlamydial HSP60, CPAF, and CT795 in inflammatory and severe trachoma. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5128-36. Skwor T, Kandel RP, Basravi S, Khan A, Sharma B, Dean D. PMID: 20463311.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    25. A systemic network for Chlamydia pneumoniae entry into human cells. J Bacteriol. 2010 Jun; 192(11):2809-15. Wang A, Johnston SC, Chou J, Dean D. PMID: 20233927.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Predicting phenotype and emerging strains among Chlamydia trachomatis infections. Emerg Infect Dis. 2009 Sep; 15(9):1385-94. Dean D, Bruno WJ, Wan R, Gomes JP, Devignot S, Mehari T, de Vries HJ, Morré SA, Myers G, Read TD, Spratt BG. PMID: 19788805.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    27. Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis. PLoS One. 2008; 3(10):e3600. Atik B, Skwor TA, Kandel RP, Sharma B, Adhikari HK, Steiner L, Erlich H, Dean D. PMID: 18974840.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e264. Skwor TA, Atik B, Kandel RP, Adhikari HK, Sharma B, Dean D. PMID: 18628987.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    29. Discovering and differentiating new and emerging clonal populations of Chlamydia trachomatis with a novel shotgun cell culture harvest assay. Emerg Infect Dis. 2008 Mar; 14(3):445-53. Somboonna N, Mead S, Liu J, Dean D. PMID: 18325260.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    30. Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control. PLoS Med. 2008 Jan 03; 5(1):e14. Dean D, Kandel RP, Adhikari HK, Hessel T. PMID: 18177205.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCellsPHPublic Health
    31. Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains. PLoS One. 2007 Sep 12; 2(9):e878. Nunes A, Gomes JP, Mead S, Florindo C, Correia H, Borrego MJ, Dean D. PMID: 17849007.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    32. Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots. Genome Res. 2007 Jan; 17(1):50-60. Gomes JP, Bruno WJ, Nunes A, Santos N, Florindo C, Borrego MJ, Dean D. PMID: 17090662.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
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