Deepak Lamba, PhD
|
Title(s) | Associate Professor, Ophthalmology |
---|
School | School of Medicine |
---|
Phone | 415-502-4969 |
---|
vCard | Download vCard |
---|
|
|
Biography University of Mumbai, Mumbai, India | MBBS | 1999 | Medicine | University of Illinois, Chicago, IL | MS | 2003 | Bioengineering | University of Washington, Seattle, WA | PhD | 2007 | Neurobiology | University of Washington , Seattle, WA | Post-doc | 2010 | Stem Cells/Retina | University of California, San Francisco, CA | | 2018 | Diversity, Equity, and Inclusion Champion Training |
ARVO | 2011 | | ARVO-AFER/Merck Innovative Ophthalmology Research Award in Stem Cells-1st Place | New York Academy of Sciences/AMED. | 2017 | | Interstellar Initiative, New York Academy of Sciences/AMED. Top Team-Regenerative Medicine |
Overview My lab focuses on retinal repair following inherited and age-associated degeneration and modeling disease-in-a-dish using stem cells technologies. I have been involved in this work since 2004 as a graduate student in Dr. Thomas Reh's lab. We have developed in vitro methodologies for generating all the various retinal cell types, including retinal neurons and retinal pigment epithelium cells, from both human and mouse embryonic stem cells and induced pluripotent stem cells. I was one of the first to publish directed retinal differentiation protocols in the US and the use of these cells for regenerative medicine. In October 2011, I established my own lab at the Buck Institute for Research on Aging, Novato, CA. The research is primarily focused on (1) exploring the potential and challenges in retinal repair and (2) using in vivo models and stem-cell based in vitro model systems to understand various retinal degenerations. In 2018, my lab moved to UCSF’s Department of Ophthalmology and housed at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research to focus on novel stem cell-based retinal therapies and bringing them closer to the clinic.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
-
MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice. Exp Gerontol. 2020 Feb 28; 134:110893.
Neves J, Chirco KR, Cedron-Craft W, Chew S, Zhu J, Jasper H, Lamba DA. PMID: 32119994.
View in: PubMed Mentions: Fields:
-
1.05 Diseases and Repair Approaches in Vision. . 2020 Jan 1; 54-65.
Deepak A. Lamba, Thomas A. Reh. .
View in: Publisher Site Mentions:
-
Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species. Sci Rep. 2019 10 28; 9(1):15440.
Meyer JG, Garcia TY, Schilling B, Gibson BW, Lamba DA. PMID: 31659173.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
-
Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation. Dev Biol. 2019 09 15; 453(2):155-167.
Kaufman ML, Park KU, Goodson NB, Chew S, Bersie S, Jones KL, Lamba DA, Brzezinski JA. PMID: 31163126.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
-
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nat Metab. 2019 02; 1(2):276-290.
Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H. PMID: 31489403.
View in: PubMed Mentions:
-
Immunological Considerations for Retinal Stem Cell Therapy. Adv Exp Med Biol. 2019; 1186:99-119.
Kramer J, Chirco KR, Lamba DA. PMID: 31654387.
View in: PubMed Mentions: Fields: Translation: HumansCells
-
Small Molecule-Based Retinal Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Bio Protoc. 2018 Jun 20; 8(12).
Zhu J, Lamba DA. PMID: 30009216.
View in: PubMed Mentions:
-
Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols. Cytotherapy. 2018 06; 20(6):861-872.
Rao MS, Pei Y, Garcia TY, Chew S, Kasai T, Hisai T, Taniguchi H, Takebe T, Lamba DA, Zeng X. PMID: 29793831.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
-
Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacturing Practice-Manufactured Human Induced Pluripotent Stem Cell Line. Stem Cells Transl Med. 2018 02; 7(2):210-219.
Zhu J, Reynolds J, Garcia T, Cifuentes H, Chew S, Zeng X, Lamba DA. PMID: 29266841.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
-
Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017 May; 6(3):4.
Chao JR, Lamba DA, Klesert TR, Torre A, Hoshino A, Taylor RJ, Jayabalu A, Engel AL, Khuu TH, Wang RK, Neitz M, Neitz J, Reh TA. PMID: 28516002.
View in: PubMed Mentions:
-
LB47 Making multiple therapeutic cell products from a cGMP-compliant iPSC line. Cytotherapy. 2017 May 1; 19(5):e22.
Xianmin Zeng, Ying Pei, Helen Cifuentes, Thelma Garcia, Deepak Lamba, Mahendra Rao. .
View in: Publisher Site Mentions:
-
Modeling Neuroretinal Development and Disease in Stem Cells. Patient-Specific Stem Cells. 2017 Apr 7; 231-252.
Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
CRISPR-Based Genome Engineering in Human Stem Cells. Patient-Specific Stem Cells. 2017 Apr 7; 87-100.
Thelma Garcia, Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Stem Cells for Parkinson’s Disease. Patient-Specific Stem Cells. 2017 Apr 7; 101-114.
Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 101-114.
Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 87-100.
Thelma Garcia, Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 231-252.
Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Immunosuppression via Loss of IL2r? Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017 03 02; 20(3):374-384.e5.
Zhu J, Cifuentes H, Reynolds J, Lamba DA. PMID: 28089909.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
-
A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep. 2016 07 01; 6:29025.
Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba DA, Ramanathan A. PMID: 27364765.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
-
Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016 Jul 01; 353(6294):aaf3646.
Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba DA. PMID: 27365452.
View in: PubMed Mentions: 50 Fields: Translation: AnimalsCells
-
Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7480-8.
Garcia TY, Gutierrez M, Reynolds J, Lamba DA. PMID: 26595608.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
-
Restoring Vision: Where are We with Stem Cells?. Current Ophthalmology Reports. 2015 Sep 1; 3(3):192-199.
Jie Zhu, Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Retinal Repair Using Stem Cells. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. 2015 Jan 1; 319-341.
Mark Gutierrez, Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Directed Differentiation towards Human Neural Retinal Cells. Neural Stem Cell Assays. 2014 Dec 3; 119-127.
Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells. J Biol Chem. 2014 Nov 14; 289(46):31818-26.
PMID: 25258312.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
-
An Update on Retinal Stem Cell Therapy. Current Ophthalmology Reports. 2013 Sep 1; 1(3):113-121.
Jennifer R. Chao, Deepak A. Lamba. .
View in: Publisher Site Mentions:
-
Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells. 2013 Sep; 31(9):1737-48.
PMID: 23765801.
View in: PubMed Mentions: 41 Fields: Translation: HumansAnimalsCells
-
Human embryonic stem cell applications for retinal degenerations. Exp Eye Res. 2014 Jun; 123:151-60.
PMID: 23880530.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
-
Production and transplantation of retinal cells from human and mouse embryonic stem cells. Methods Mol Biol. 2012; 884:229-46.
PMID: 22688710.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
-
Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012 Feb; 33(5):1396-405.
PMID: 22115999.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
-
Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011; 6(8):e22817.
PMID: 21829655.
View in: PubMed Mentions: 53 Fields: Translation: AnimalsCells
-
Microarray characterization of human embryonic stem cell--derived retinal cultures. Invest Ophthalmol Vis Sci. 2011 Jul 01; 52(7):4897-906.
Lamba DA, Reh TA. PMID: 21345990.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
-
Chapter 24 Regenerative Medicine for Diseases of the Retina. Principles of Regenerative Medicine. 2011 Jan 1; 427-449.
Deepak A. Lamba, Thomas A. Reh. .
View in: Publisher Site Mentions:
-
A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn. 2010 Jul; 239(7):2034-40.
Hayashi T, Lamba DA, Slowik A, Reh TA, Bermingham-McDonogh O. PMID: 20549727.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
-
Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb; 137(4):619-29.
Brzezinski JA, Lamba DA, Reh TA. PMID: 20110327.
View in: PubMed Mentions: 44 Fields: Translation: HumansAnimalsCells
-
Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010 Jan 20; 5(1):e8763.
Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. PMID: 20098701.
View in: PubMed Mentions: 148 Fields: Translation: HumansCells
-
Directing human embryonic stem cells to a retinal fate. Methods Mol Biol. 2010; 636:139-53.
Reh TA, Lamba D, Gust J. PMID: 20336521.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
-
Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):359-69.
Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA. PMID: 19341625.
View in: PubMed Mentions: 71 Fields: Translation: HumansAnimalsCells
-
Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009 Jan 09; 4(1):73-9.
Lamba DA, Gust J, Reh TA. PMID: 19128794.
View in: PubMed Mentions: 210 Fields: Translation: HumansAnimalsCells
-
Strategies for retinal repair: cell replacement and regeneration. Prog Brain Res. 2009; 175:23-31.
Lamba DA, Karl MO, Reh TA. PMID: 19660646.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
-
Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008 Oct; 237(10):3016-23.
Lamba DA, Hayes S, Karl MO, Reh T. PMID: 18816825.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
-
Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008 Jun 05; 2(6):538-49.
Lamba D, Karl M, Reh T. PMID: 18522847.
View in: PubMed Mentions: 57 Fields: Translation: HumansAnimals
-
23 Regenerative Medicine for Diseases of the Retina. Principles of Regenerative Medicine. 2008 Jan 1; 418-436.
Deepak Lamba, Thomas A. Reh. .
View in: Publisher Site Mentions:
-
Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12769-74.
Lamba DA, Karl MO, Ware CB, Reh TA. PMID: 16908856.
View in: PubMed Mentions: 231 Fields: Translation: HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
---|
2006 | 1 | 2008 | 3 | 2009 | 3 | 2010 | 4 | 2011 | 4 | 2012 | 1 | 2013 | 3 | 2014 | 2 | 2015 | 3 | 2016 | 2 | 2017 | 10 | 2018 | 2 | 2019 | 4 | 2020 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
newest
oldest
line numbers
double spacing
all authors
publication IDs
|
Derived automatically from this person's publications.
_
People in Profiles who have published with this person.
_
People who share similar concepts with this person.
_
Search Department
_
|