Deepak Lamba, PhD

TitleAdjunct Instructor
SchoolUCSF School of Medicine
Address35 Medical Center Way
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of Mumbai, Mumbai, IndiaMBBS1999Medicine
    University of Illinois, Chicago, ILMS2003Bioengineering
    University of Washington, Seattle, WAPhD2007Neurobiology
    University of Washington , Seattle, WAPost-doc2010Stem Cells/Retina
    Collapse Awards and Honors
    ARVO2011ARVO-AFER/Merck Innovative Ophthalmology Research Award in Stem Cells-1st Place
    New York Academy of Sciences/AMED.2017Interstellar Initiative, New York Academy of Sciences/AMED. Top Team-Regenerative Medicine

    Collapse Overview 
    Collapse Overview
    My lab focuses on retinal repair and disease modeling for which I have gained relevant expertise by working with stem cell technologies for retinal repair for about 15 years. This has provided me with unique and extensive knowledge and skills to carry out the proposed work. We have developed in vitro methodologies for generating all the various retinal cell types, including retinal neurons and retinal pigment epithelium cells, from both human embryonic stem cells and human induced pluripotent stem cells. I was one of the first to publish directed retinal differentiation protocols in the US and the use of these cells for regenerative medicine. In October 2011, I established my own lab at the Buck Institute for Research on Aging, Novato, CA. The research is primarily focused on (1) exploring the potential and challenges in retinal repair and (2) using in vivo models and stem-cell based in vitro model systems to understand various retinal degenerations. In 2018, my lab moved to UCSF’s Institute of Regenerative Medicine and affiliated to the Department of Ophthalmology to more closely focus on novel stem cell-based retinal therapies and bringing them closer to the clinic.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhu J, Reynolds J, Garcia T, Cifuentes H, Chew S, Zeng X, Lamba D. Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacturing Practice-Manufactured Human Induced Pluripotent Stem Cell Line. Stem Cells Transl Med. 2018 Feb; 7(2):210-219. PMID: 29266841.
      View in: PubMed
    2. Chao JR, Lamba D, Klesert TR, Torre A, Hoshino A, Taylor RJ, Jayabalu A, Engel AL, Khuu TH, Wang RK, Neitz M, Neitz J, Reh TA. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017 May; 6(3):4. PMID: 28516002.
      View in: PubMed
    3. Zhu J, Cifuentes H, Reynolds J, Lamba D. Immunosuppression via Loss of IL2r? Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017 03 02; 20(3):374-384.e5. PMID: 28089909.
      View in: PubMed
    4. Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba D, Ramanathan A. A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep. 2016 Jul 01; 6:29025. PMID: 27364765; PMCID: PMC4929558.
    5. Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba D. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016 Jul 01; 353(6294):aaf3646. PMID: 27365452.
      View in: PubMed
    6. Garcia TY, Gutierrez M, Reynolds J, Lamba D. Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7480-8. PMID: 26595608.
      View in: PubMed
    7. Agrawal P, Reynolds J, Chew S, Lamba D, Hughes RE. DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells. J Biol Chem. 2014 Nov 14; 289(46):31818-26. PMID: 25258312; PMCID: PMC4231659.
    8. Mathieu J, Zhang Z, Nelson A, Lamba D, Reh TA, Ware C, Ruohola-Baker H. Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells. 2013 Sep; 31(9):1737-48. PMID: 23765801; PMCID: PMC3921075.
    9. Reynolds J, Lamba D. Human embryonic stem cell applications for retinal degenerations. Exp Eye Res. 2014 Jun; 123:151-60. PMID: 23880530.
      View in: PubMed
    10. La Torre A, Lamba D, Jayabalu A, Reh TA. Production and transplantation of retinal cells from human and mouse embryonic stem cells. Methods Mol Biol. 2012; 884:229-46. PMID: 22688710.
      View in: PubMed
    11. McUsic AC, Lamba D, Reh TA. Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012 Feb; 33(5):1396-405. PMID: 22115999; PMCID: PMC3249403.
    12. Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba D, Reh TA. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011; 6(8):e22817. PMID: 21829655; PMCID: PMC3149061.
    13. Lamba D, Reh TA. Microarray characterization of human embryonic stem cell--derived retinal cultures. Invest Ophthalmol Vis Sci. 2011 Jul 01; 52(7):4897-906. PMID: 21345990; PMCID: PMC3175935.
    14. Hayashi T, Lamba D, Slowik A, Reh TA, Bermingham-McDonogh O. A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn. 2010 Jul; 239(7):2034-40. PMID: 20549727; PMCID: PMC2933403.
    15. Brzezinski JA, Lamba D, Reh TA. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb; 137(4):619-29. PMID: 20110327; PMCID: PMC2827615.
    16. Lamba D, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010 Jan 20; 5(1):e8763. PMID: 20098701.
      View in: PubMed
    17. Reh TA, Lamba D, Gust J. Directing human embryonic stem cells to a retinal fate. Methods Mol Biol. 2010; 636:139-53. PMID: 20336521.
      View in: PubMed
    18. Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba D, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA. Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):359-69. PMID: 19341625; PMCID: PMC2719860.
    19. Lamba D, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009 Jan 09; 4(1):73-9. PMID: 19128794; PMCID: PMC2713676.
    20. Lamba D, Karl MO, Reh TA. Strategies for retinal repair: cell replacement and regeneration. Prog Brain Res. 2009; 175:23-31. PMID: 19660646.
      View in: PubMed
    21. Lamba D, Hayes S, Karl MO, Reh T. Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008 Oct; 237(10):3016-23. PMID: 18816825; PMCID: PMC2707830.
    22. Lamba D, Karl M, Reh T. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008 Jun 05; 2(6):538-49. PMID: 18522847; PMCID: PMC2692223.
    23. Lamba D, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12769-74. PMID: 16908856; PMCID: PMC1568922.
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