Deepak Lamba, PhD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of Mumbai, Mumbai, IndiaMBBS1999Medicine
    University of Illinois, Chicago, ILMS2003Bioengineering
    University of Washington, Seattle, WAPhD2007Neurobiology
    University of Washington , Seattle, WAPost-doc2010Stem Cells/Retina
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    ARVO2011ARVO-AFER/Merck Innovative Ophthalmology Research Award in Stem Cells-1st Place
    New York Academy of Sciences/AMED.2017Interstellar Initiative, New York Academy of Sciences/AMED. Top Team-Regenerative Medicine

    Collapse Overview 
    Collapse Overview
    My lab focuses on retinal repair following inherited and age-associated degeneration and modeling disease-in-a-dish using stem cells technologies. I have been involved in this work since 2004 as a graduate student in Dr. Thomas Reh's lab. We have developed in vitro methodologies for generating all the various retinal cell types, including retinal neurons and retinal pigment epithelium cells, from both human and mouse embryonic stem cells and induced pluripotent stem cells. I was one of the first to publish directed retinal differentiation protocols in the US and the use of these cells for regenerative medicine. In October 2011, I established my own lab at the Buck Institute for Research on Aging, Novato, CA. The research is primarily focused on (1) exploring the potential and challenges in retinal repair and (2) using in vivo models and stem-cell based in vitro model systems to understand various retinal degenerations. In 2018, my lab moved to UCSF’s Department of Ophthalmology and housed at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research to focus on novel stem cell-based retinal therapies and bringing them closer to the clinic.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
    NIH R01EY032197Jan 1, 2021 - Nov 30, 2025
    Role: Principal Investigator
    Strategies for cone photoreceptor development and regenerative medicine
    NIH/NEI U24EY029891Sep 30, 2018 - Aug 31, 2023
    Role: Co-Investigator
    Targeting Inflammaging with Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF).
    NIH R56AG052989Jun 1, 2016 - May 31, 2017
    Role: Co-Principal Investigator
    Enhancing photoreceptor integration using microglia-derived secreted factors
    NIH R01EY025779Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation. eLife. 2024 Apr 25; 12. Kandoi KS, Martinez MC, Chen CK, Mehine MM, Reddy RL, Mansfield MB, Duncan DJ, Lamba LD. .
      View in: Publisher Site   Mentions:
    2. Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation. Elife. 2024 Apr 25; 12. Kandoi S, Martinez C, Chen KX, Mehine M, Reddy LVK, Mansfield BC, Duncan JL, Lamba DA. PMID: 38661530; PMCID: PMC11045220.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel. Stem Cell Reports. 2024 Mar 12; 19(3):331-342. Yu CT, Kandoi S, Periasamy R, Reddy LVK, Follett HM, Summerfelt P, Martinez C, Guillaume C, Bowie O, Connor TB, Lipinski DM, Allen KP, Merriman DK, Carroll J, Lamba DA. PMID: 38335965; PMCID: PMC10937153.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation. medRxiv. 2023 Nov 06. Kandoi S, Martinez C, Chen KX, Reddy LVK, Mehine M, Mansfield BC, Duncan JL, Lamba DA. PMID: 36909455; PMCID: PMC10002783.
      View in: PubMed   Mentions:
    5. Factors Affecting Stem Cell-Based Regenerative Approaches in Retinal Degeneration. Annu Rev Vis Sci. 2023 09 15; 9:155-175. Patel SH, Lamba DA. PMID: 37713278.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Advancements in pre-clinical development of gene editing-based therapies to treat inherited retinal diseases. Vision Res. 2023 08; 209:108257. Chirco KR, Martinez C, Lamba DA. PMID: 37210864; PMCID: PMC10524382.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. The importance of unambiguous cell origin determination in neuronal repopulation studies. iScience. 2023 Apr 21; 26(4):106361. Johnson TV, Calkins DJ, Fortune B, Goldberg JL, La Torre A, Lamba DA, Meyer JS, Reh TA, Wallace VA, Zack DJ, Baranov P. PMID: 37009209; PMCID: PMC10060674.
      View in: PubMed   Mentions: 2  
    8. Retinal Organoids: A Human Model System for Development, Diseases, and Therapies. Adv Exp Med Biol. 2023; 1415:549-554. Kandoi S, Lamba DA. PMID: 37440085.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Characterization of Retinal Development in 13-Lined Ground Squirrels. Transl Vis Sci Technol. 2022 11 01; 11(11):17. Kandoi S, Martinez C, Merriman DK, Lamba DA. PMID: 36409292; PMCID: PMC9695149.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids. Invest Ophthalmol Vis Sci. 2022 09 01; 63(10):12. Chew SH, Martinez C, Chirco KR, Kandoi S, Lamba DA. PMID: 36129723; PMCID: PMC9513742.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Biophysical, Molecular and Proteomic Profiling of Human Retinal Organoid-Derived Exosomes. Pharm Res. 2023 Apr; 40(4):801-816. Arthur P, Kandoi S, Sun L, Kalvala A, Kutlehria S, Bhattacharya S, Kulkarni T, Nimma R, Li Y, Lamba DA, Singh M. PMID: 36002615; PMCID: PMC10576571.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. An enhancer located in a Pde6c intron drives transient expression in the cone photoreceptors of developing mouse and human retinas. Dev Biol. 2022 08; 488:131-150. Bachu VS, Kandoi S, Park KU, Kaufman ML, Schwanke M, Lamba DA, Brzezinski JA. PMID: 35644251; PMCID: PMC10676565.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina. PLoS One. 2021; 16(10):e0258872. Kramer J, Neves J, Koniikusic M, Jasper H, Lamba DA. PMID: 34699550; PMCID: PMC8547621.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model. Stem Cell Reports. 2021 11 09; 16(11):2690-2702. Chirco KR, Chew S, Moore AT, Duncan JL, Lamba DA. PMID: 34653402; PMCID: PMC8580887.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice. Exp Gerontol. 2020 Feb 28; 134:110893. Neves J, Chirco KR, Cedron-Craft W, Chew S, Zhu J, Jasper H, Lamba DA. PMID: 32119994; PMCID: PMC7483617.
      View in: PubMed   Mentions: 6     Fields:    
    16. 1.05 Diseases and Repair Approaches in Vision. . 2020 Jan 1; 54-65. Lamba LD, Reh RT. .
      View in: Publisher Site   Mentions:
    17. Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species. Sci Rep. 2019 10 28; 9(1):15440. Meyer JG, Garcia TY, Schilling B, Gibson BW, Lamba DA. PMID: 31659173; PMCID: PMC6817852.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    18. Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation. Dev Biol. 2019 09 15; 453(2):155-167. Kaufman ML, Park KU, Goodson NB, Chew S, Bersie S, Jones KL, Lamba DA, Brzezinski JA. PMID: 31163126; PMCID: PMC7722777.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    19. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nat Metab. 2019 02; 1(2):276-290. Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H. PMID: 31489403; PMCID: PMC6727652.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    20. Immunological Considerations for Retinal Stem Cell Therapy. Adv Exp Med Biol. 2019; 1186:99-119. Kramer J, Chirco KR, Lamba DA. PMID: 31654387.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Small Molecule-Based Retinal Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Bio Protoc. 2018 Jun 20; 8(12). Zhu J, Lamba DA. PMID: 30009216; PMCID: PMC6039118.
      View in: PubMed   Mentions: 1  
    22. Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols. Cytotherapy. 2018 06; 20(6):861-872. Rao MS, Pei Y, Garcia TY, Chew S, Kasai T, Hisai T, Taniguchi H, Takebe T, Lamba DA, Zeng X. PMID: 29793831.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacturing Practice-Manufactured Human Induced Pluripotent Stem Cell Line. Stem Cells Transl Med. 2018 02; 7(2):210-219. Zhu J, Reynolds J, Garcia T, Cifuentes H, Chew S, Zeng X, Lamba DA. PMID: 29266841; PMCID: PMC5788871.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    24. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017 May; 6(3):4. Chao JR, Lamba DA, Klesert TR, Torre A, Hoshino A, Taylor RJ, Jayabalu A, Engel AL, Khuu TH, Wang RK, Neitz M, Neitz J, Reh TA. PMID: 28516002; PMCID: PMC5433804.
      View in: PubMed   Mentions: 40     Fields:    
    25. LB47 Making multiple therapeutic cell products from a cGMP-compliant iPSC line. Cytotherapy. 2017 May 1; 19(5):e22. Zeng ZX, Pei PY, Cifuentes CH, Garcia GT, Lamba LD, Rao RM. .
      View in: Publisher Site   Mentions:
    26. Modeling Neuroretinal Development and Disease in Stem Cells. Patient-Specific Stem Cells. 2017 Apr 7; 231-252. Lamba LD. .
      View in: Publisher Site   Mentions:
    27. CRISPR-Based Genome Engineering in Human Stem Cells. Patient-Specific Stem Cells. 2017 Apr 7; 87-100. Garcia GT, Lamba LD. .
      View in: Publisher Site   Mentions:
    28. Stem Cells for Parkinson’s Disease. Patient-Specific Stem Cells. 2017 Apr 7; 101-114. Lamba LD. .
      View in: Publisher Site   Mentions:
    29. Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 231-252. Lamba LD. .
      View in: Publisher Site   Mentions:
    30. Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 101-114. Lamba LD. .
      View in: Publisher Site   Mentions:
    31. Patient-Specific Stem Cells. Patient-Specific Stem Cells. 2017 Mar 9; 87-100. Garcia GT, Lamba LD. .
      View in: Publisher Site   Mentions:
    32. Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017 03 02; 20(3):374-384.e5. Zhu J, Cifuentes H, Reynolds J, Lamba DA. PMID: 28089909.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    33. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016 Jul 01; 353(6294):aaf3646. Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba DA. PMID: 27365452; PMCID: PMC5270511.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    34. A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep. 2016 07 01; 6:29025. Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba DA, Ramanathan A. PMID: 27364765; PMCID: PMC4929558.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7480-8. Garcia TY, Gutierrez M, Reynolds J, Lamba DA. PMID: 26595608.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    36. Restoring Vision: Where are We with Stem Cells?. Current Ophthalmology Reports. 2015 Sep 1; 3(3):192-199. Zhu ZJ, Lamba LD. .
      View in: Publisher Site   Mentions:
    37. Retinal Repair Using Stem Cells. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. 2015 Jan 1; 319-341. Gutierrez GM, Lamba LD. .
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    38. Directed Differentiation towards Human Neural Retinal Cells. Neural Stem Cell Assays. 2014 Dec 3; 119-127. Lamba LD. .
      View in: Publisher Site   Mentions:
    39. DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells. J Biol Chem. 2014 Nov 14; 289(46):31818-31826. Agrawal P, Reynolds J, Chew S, Lamba DA, Hughes RE. PMID: 25258312; PMCID: PMC4231659.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    40. Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells. 2013 Sep; 31(9):1737-48. Mathieu J, Zhang Z, Nelson A, Lamba DA, Reh TA, Ware C, Ruohola-Baker H. PMID: 23765801; PMCID: PMC3921075.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    41. An Update on Retinal Stem Cell Therapy. Current Ophthalmology Reports. 2013 Sep 1; 1(3):113-121. Chao CJ, Lamba LD. .
      View in: Publisher Site   Mentions:
    42. Human embryonic stem cell applications for retinal degenerations. Exp Eye Res. 2014 Jun; 123:151-60. Reynolds J, Lamba DA. PMID: 23880530.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. Production and transplantation of retinal cells from human and mouse embryonic stem cells. Methods Mol Biol. 2012; 884:229-46. La Torre A, Lamba DA, Jayabalu A, Reh TA. PMID: 22688710.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012 Feb; 33(5):1396-405. McUsic AC, Lamba DA, Reh TA. PMID: 22115999; PMCID: PMC3249403.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    45. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011; 6(8):e22817. Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba DA, Reh TA. PMID: 21829655; PMCID: PMC3149061.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    46. Microarray characterization of human embryonic stem cell--derived retinal cultures. Invest Ophthalmol Vis Sci. 2011 Jul 01; 52(7):4897-906. Lamba DA, Reh TA. PMID: 21345990; PMCID: PMC3175935.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    47. Chapter 24 Regenerative Medicine for Diseases of the Retina. Principles of Regenerative Medicine. 2011 Jan 1; 427-449. Lamba LD, Reh RT. .
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    48. A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn. 2010 Jul; 239(7):2034-40. Hayashi T, Lamba DA, Slowik A, Reh TA, Bermingham-McDonogh O. PMID: 20549727; PMCID: PMC2933403.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    49. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb; 137(4):619-29. Brzezinski JA, Lamba DA, Reh TA. PMID: 20110327; PMCID: PMC2827615.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    50. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010 Jan 20; 5(1):e8763. Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. PMID: 20098701; PMCID: PMC2808350.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCells
    51. Directing human embryonic stem cells to a retinal fate. Methods Mol Biol. 2010; 636:139-53. Reh TA, Lamba D, Gust J. PMID: 20336521.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    52. Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):359-69. Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA. PMID: 19341625; PMCID: PMC2719860.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    53. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009 Jan 09; 4(1):73-9. Lamba DA, Gust J, Reh TA. PMID: 19128794; PMCID: PMC2713676.
      View in: PubMed   Mentions: 278     Fields:    Translation:HumansAnimalsCells
    54. Strategies for retinal repair: cell replacement and regeneration. Prog Brain Res. 2009; 175:23-31. Lamba DA, Karl MO, Reh TA. PMID: 19660646.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    55. Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008 Oct; 237(10):3016-23. Lamba DA, Hayes S, Karl MO, Reh T. PMID: 18816825; PMCID: PMC2707830.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    56. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008 Jun 05; 2(6):538-49. Lamba D, Karl M, Reh T. PMID: 18522847; PMCID: PMC2692223.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    57. 23 Regenerative Medicine for Diseases of the Retina. Principles of Regenerative Medicine. 2008 Jan 1; 418-436. Lamba LD, Reh RT. .
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    58. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12769-74. Lamba DA, Karl MO, Ware CB, Reh TA. PMID: 16908856; PMCID: PMC1568922.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansAnimalsCells