Deepak Lamba, PhD

Title(s)Associate Professor, Ophthalmology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of Mumbai, Mumbai, IndiaMBBS1999Medicine
    University of Illinois, Chicago, ILMS2003Bioengineering
    University of Washington, Seattle, WAPhD2007Neurobiology
    University of Washington , Seattle, WAPost-doc2010Stem Cells/Retina
    Collapse Awards and Honors
    ARVO2011ARVO-AFER/Merck Innovative Ophthalmology Research Award in Stem Cells-1st Place
    New York Academy of Sciences/AMED.2017Interstellar Initiative, New York Academy of Sciences/AMED. Top Team-Regenerative Medicine

    Collapse Overview 
    Collapse Overview
    My lab focuses on retinal repair following inherited and age-associated degeneration and modeling disease-in-a-dish using stem cells technologies. I have been involved in this work since 2004 as a graduate student in Dr. Thomas Reh's lab. We have developed in vitro methodologies for generating all the various retinal cell types, including retinal neurons and retinal pigment epithelium cells, from both human and mouse embryonic stem cells and induced pluripotent stem cells. I was one of the first to publish directed retinal differentiation protocols in the US and the use of these cells for regenerative medicine. In October 2011, I established my own lab at the Buck Institute for Research on Aging, Novato, CA. The research is primarily focused on (1) exploring the potential and challenges in retinal repair and (2) using in vivo models and stem-cell based in vitro model systems to understand various retinal degenerations. In 2018, my lab moved to UCSF’s Department of Ophthalmology and housed at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research to focus on novel stem cell-based retinal therapies and bringing them closer to the clinic.

    Collapse Research 
    Collapse Research Activities and Funding
    Strategies for cone photoreceptor development and regenerative medicine
    NIH/NEI U24EY029891Sep 30, 2018 - Aug 31, 2023
    Role: Co-Investigator
    Targeting Inflammaging with Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF).
    NIH/NIA R56AG052989Jun 1, 2016 - May 31, 2017
    Role: Co-Principal Investigator
    Enhancing photoreceptor integration using microglia-derived secreted factors
    NIH/NEI R01EY025779Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kaufman ML, Park KU, Goodson NB, Chew S, Bersie S, Jones KL, Lamba DA, Brzezinski JA. Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation. Dev Biol. 2019 Jun 01. PMID: 31163126.
      View in: PubMed
    2. Pedro Sousa-Victor, Joana Neves, Wendy Cedron-Craft, P. Britten Ventura, Chen-Yu Liao, Rebeccah R. Riley, Ilya Soifer, Nicholas van Bruggen, Ganesh A. Kolumam, Saul A. Villeda, Deepak A. Lamba, Heinrich Jasper.MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism. 2019; (1):276–290.
    3. Zhu J, Lamba DA. Small Molecule-Based Retinal Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Bio Protoc. 2018 Jun 20; 8(12). PMID: 30009216.
      View in: PubMed
    4. Rao MS, Pei Y, Garcia TY, Chew S, Kasai T, Hisai T, Taniguchi H, Takebe T, Lamba DA, Zeng X. Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols. Cytotherapy. 2018 Jun; 20(6):861-872. PMID: 29793831.
      View in: PubMed
    5. Zhu J, Reynolds J, Garcia T, Cifuentes H, Chew S, Zeng X, Lamba DA. Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacturing Practice-Manufactured Human Induced Pluripotent Stem Cell Line. Stem Cells Transl Med. 2018 Feb; 7(2):210-219. PMID: 29266841.
      View in: PubMed
    6. Chao JR, Lamba DA, Klesert TR, Torre A, Hoshino A, Taylor RJ, Jayabalu A, Engel AL, Khuu TH, Wang RK, Neitz M, Neitz J, Reh TA. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017 May; 6(3):4. PMID: 28516002.
      View in: PubMed
    7. Zhu J, Cifuentes H, Reynolds J, Lamba DA. Immunosuppression via Loss of IL2r? Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017 03 02; 20(3):374-384.e5. PMID: 28089909.
      View in: PubMed
    8. Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba DA. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016 Jul 01; 353(6294):aaf3646. PMID: 27365452.
      View in: PubMed
    9. Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba DA, Ramanathan A. A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep. 2016 07 01; 6:29025. PMID: 27364765.
      View in: PubMed
    10. Garcia TY, Gutierrez M, Reynolds J, Lamba DA. Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7480-8. PMID: 26595608.
      View in: PubMed
    11. Agrawal P, Reynolds J, Chew S, Lamba DA, Hughes RE. DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells. J Biol Chem. 2014 Nov 14; 289(46):31818-26. PMID: 25258312; PMCID: PMC4231659.
    12. Mathieu J, Zhang Z, Nelson A, Lamba DA, Reh TA, Ware C, Ruohola-Baker H. Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells. 2013 Sep; 31(9):1737-48. PMID: 23765801.
      View in: PubMed
    13. Reynolds J, Lamba DA. Human embryonic stem cell applications for retinal degenerations. Exp Eye Res. 2014 Jun; 123:151-60. PMID: 23880530.
      View in: PubMed
    14. La Torre A, Lamba DA, Jayabalu A, Reh TA. Production and transplantation of retinal cells from human and mouse embryonic stem cells. Methods Mol Biol. 2012; 884:229-46. PMID: 22688710.
      View in: PubMed
    15. McUsic AC, Lamba DA, Reh TA. Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012 Feb; 33(5):1396-405. PMID: 22115999.
      View in: PubMed
    16. Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba DA, Reh TA. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011; 6(8):e22817. PMID: 21829655.
      View in: PubMed
    17. Lamba DA, Reh TA. Microarray characterization of human embryonic stem cell--derived retinal cultures. Invest Ophthalmol Vis Sci. 2011 Jul 01; 52(7):4897-906. PMID: 21345990; PMCID: PMC3175935.
    18. Hayashi T, Lamba DA, Slowik A, Reh TA, Bermingham-McDonogh O. A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn. 2010 Jul; 239(7):2034-40. PMID: 20549727.
      View in: PubMed
    19. Brzezinski JA, Lamba DA, Reh TA. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb; 137(4):619-29. PMID: 20110327; PMCID: PMC2827615.
    20. Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010 Jan 20; 5(1):e8763. PMID: 20098701.
      View in: PubMed
    21. Reh TA, Lamba D, Gust J. Directing human embryonic stem cells to a retinal fate. Methods Mol Biol. 2010; 636:139-53. PMID: 20336521.
      View in: PubMed
    22. Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA. Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):359-69. PMID: 19341625; PMCID: PMC2719860.
    23. Lamba DA, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009 Jan 09; 4(1):73-9. PMID: 19128794.
      View in: PubMed
    24. Lamba DA, Karl MO, Reh TA. Strategies for retinal repair: cell replacement and regeneration. Prog Brain Res. 2009; 175:23-31. PMID: 19660646.
      View in: PubMed
    25. Lamba DA, Hayes S, Karl MO, Reh T. Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008 Oct; 237(10):3016-23. PMID: 18816825.
      View in: PubMed
    26. Lamba D, Karl M, Reh T. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008 Jun 05; 2(6):538-49. PMID: 18522847; PMCID: PMC2692223.
    27. Lamba DA, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12769-74. PMID: 16908856.
      View in: PubMed