Dr. Yu's research program focuses on evaluating endotypes and subphenotypes of nutrition-related diseases, with the long-term goals of identifying earlier and subclinical indicators of pathogenesis to improve prevention efforts. Nutrition-related diseases of interest include metabolic abnormalities and diseases such as diabetes and infectious diseases. Key questions of interest are centered around three themes: 1) metabolic health and homeostasis; 2) novel biomarkers of nutrition-related diseases; and 3) diverse clinical manifestations of nutrition-related diseases. Her epidemiologic approach is centered around blood biomarkers, including high-resolution metabolomic data, in translational and precision health studies. Previous and future study populations of interest include people considered higher risk, particularly those residing in resource-limited environments or with medical conditions requiring blood transfusions, and blood donors.