Rachael Jackman, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
AddressVitalant Research Institute
270 Masonic Ave
San Francisco CA 94118
Phone415-923-5773
ORCID ORCID Icon0000-0001-8591-7819 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    The impact of illness and medical treatments on the alloantibody response to platelet transfusion
    NIH R01HL144501Jul 17, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Mechanisms regulating alloimmunization and tolerance with pathogen reduction and transfusion of allogeneic platelets
    NIH R01HL133024Jul 1, 2016 - Apr 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice. Front Immunol. 2023; 14:1281130. Tran JQ, Muench MO, Gaillard B, Darst O, Tomayko MM, Jackman RP. PMID: 38146372; PMCID: PMC10749330.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice. Front Immunol. 2023; 14:1281123. Jackman RP, Darst O, Gaillard B, Tran JQ, Tomayko MM, Muench MO. PMID: 38090570; PMCID: PMC10711281.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity. Adv Nutr. 2023 09; 14(5):1145-1158. Yu EA, Jackman RP, Glesby MJ, Narayan KV. PMID: 37302794; PMCID: PMC10256583.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasma. J Clin Invest. 2022 09 01; 132(17). Saá P, Fink RV, Bakkour S, Jin J, Simmons G, Muench MO, Dawar H, Di Germanio C, Hui AJ, Wright DJ, Krysztof DE, Kleinman SH, Cheung A, Nester T, Kessler DA, Townsend RL, Spencer BR, Kamel H, Vannoy JM, Dave H, Busch MP, Stramer SL, Stone M, Jackman RP, Norris PJ, NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P). PMID: 35834347; PMCID: PMC9435642.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice. Blood Adv. 2020 11 10; 4(21):5547-5561. Tran JQ, Muench MO, Jackman RP. PMID: 33166410; PMCID: PMC7656940.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress. Transfusion. 2021 02; 61(2):435-448. Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T. PMID: 33146433; PMCID: PMC7902376.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    7. Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice. PLoS One. 2020; 15(7):e0237106. Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO. PMID: 32735605; PMCID: PMC7394438.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    8. A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice. Vox Sang. 2020 Jul; 115(5):367-376. Jackman RP, Heitman JW, Muench MO. PMID: 32201962; PMCID: PMC7374020.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes. Transfusion. 2019 11; 59(11):3501-3510. Tran JQ, Muench MO, Heitman JW, Jackman RP. PMID: 31599981; PMCID: PMC7391079.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Lack of persistent microchimerism in contemporary transfused trauma patients. Transfusion. 2019 11; 59(11):3329-3336. Jackman RP, Utter GH, Lee TH, Montalvo L, Wen L, Chafets D, Rivers RM, Kopko PM, Norris PJ, Busch MP. PMID: 31518003; PMCID: PMC7408297.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations. Transplant Direct. 2019 Jun; 5(6):e460. Togarrati PP, Dinglasan N, Yee E, Heitman JW, Jackman RP, Geisberg M, Norris PJ, Bárcena A, Muench MO. PMID: 31321294; PMCID: PMC6553624.
      View in: PubMed   Mentions: 1  
    12. Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice. Vox Sang. 2019 Apr; 114(3):207-215. Tran JQ, Muench MO, Heitman JW, Jackman RP. PMID: 30734299; PMCID: PMC6465144.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis. Lupus Sci Med. 2018; 5(1):e000278. Jackman RP, Cruz GI, Nititham J, Triulzi DJ, Barcellos LF, Criswell LA, Norris PJ, Busch MP. PMID: 30305912; PMCID: PMC6173266.
      View in: PubMed   Mentions: 3     Fields:    
    14. Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood. Transfusion. 2017 02; 57(2):337-348. Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ. PMID: 27859333; PMCID: PMC5401816.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    15. C1q-binding anti-HLA antibodies do not predict platelet transfusion failure in Trial to Reduce Alloimmunization to Platelets study participants. Transfusion. 2016 06; 56(6):1442-50. Jackman RP, Lee JH, Pei R, Bolgiano D, Lebedeva M, Slichter SJ, Norris PJ. PMID: 27079754; PMCID: PMC6016838.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets. Transfusion. 2016 06; 56(6):1419-29. Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP. PMID: 27028210.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood. 2014 Jan 30; 123(5):687-96. Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ. PMID: 24335232; PMCID: PMC3907755.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    18. Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response. Transfusion. 2014 Mar; 54(3):672-80. Jackman RP, Deng X, Bolgiano D, Utter GH, Schechterly C, Lebedeva M, Operskalski E, Luban NL, Alter H, Busch MP, Slichter SJ, Norris PJ. PMID: 23808544; PMCID: PMC3825847.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    19. Immunomodulation in transfused trauma patients. Curr Opin Anaesthesiol. 2013 Apr; 26(2):196-203. Jackman RP. PMID: 23303513; PMCID: PMC3747969.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    20. Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice. Transfusion. 2013 Nov; 53(11):2697-709. Jackman RP, Muench MO, Heitman JW, Inglis HC, Law JP, Marschner S, Goodrich RP, Norris PJ. PMID: 23451715.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants. Blood. 2013 Apr 18; 121(16):3261-6; quiz 3299. Jackman RP, Deng X, Bolgiano D, Lebedeva M, Heitman JW, Busch MP, Slichter SJ, Norris PJ. PMID: 23393051; PMCID: PMC3630837.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Transfusion-associated microchimerism: the hybrid within. Transfus Med Rev. 2013 Jan; 27(1):10-20. Bloch EM, Jackman RP, Lee TH, Busch MP. PMID: 23102759; PMCID: PMC3518667.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    23. Distinct roles of trauma and transfusion in induction of immune modulation after injury. Transfusion. 2012 Dec; 52(12):2533-50. Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ. PMID: 22452342; PMCID: PMC3392528.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    24. Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma. Clin Vaccine Immunol. 2011 Feb; 18(2):318-26. Jackman RP, Utter GH, Heitman JW, Hirschkorn DF, Law JP, Gefter N, Busch MP, Norris PJ. PMID: 21159926; PMCID: PMC3067358.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    25. Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment. Transfusion. 2009 Dec; 49(12):2686-99. Jackman RP, Heitman JW, Marschner S, Goodrich RP, Norris PJ. PMID: 19682337; PMCID: PMC2865145.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. J Immunol. 2007 May 01; 178(9):5543-51. Jackman RP, Balamuth F, Bottomly K. PMID: 17442936.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte antigen variation. J Infect Dis. 2004 Mar 15; 189(6):1084-90. Louie LG, Hartogensis WE, Jackman RP, Schultz KA, Zijenah LS, Yiu CH, Nguyen VD, Sohsman MY, Katzenstein DK, Mason PR. PMID: 14999612.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
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