Erica Hutchins, PhD

Title(s)Assistant Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSW, #740
San Francisco CA 94143
Phone--
ORCID ORCID Icon0000-0002-4316-0333 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA08/2022Diversity, Equity, and Inclusion Champion Training
    California Institute of Technology, Pasadena, CAPostdoctoral Training07/2022Developmental Biology
    University at Albany, State University of New York, Albany, NYPhD12/2013Biology

    Collapse Overview 
    Collapse Overview
    The Hutchins Lab seeks to map how post-transcriptional regulation controls developmental pluripotency and cell fate decisions in vivo, using vertebrate neural crest as a model.

    Neural crest cells are an essential stem cell population in the vertebrate embryo. During development, these cells must undergo coordinated induction, specification, and epithelial—mesenchymal transition (EMT) events to migrate and ultimately develop into a wide range of cell types that contribute to the adult organism.

    Dysregulated post-transcriptional regulatory linkages in neural crest can lead to congenital malformations and cancer in humans, and a thorough understanding of the mechanisms underlying these fundamental processes can provide new therapeutic targets for biomedical intervention.

    By leveraging systems-level approaches and cutting-edge developmental biology techniques to understand how neural crest cell state transitions are achieved post-transcriptionally to drive cell fate choices, we can begin to understand how these programs fail during development or may be hijacked during disease.

    The major research goals of our laboratory are:
    1) To identify the post-transcriptional regulatory linkages controlling neural crest fate decisions across developmental time and space
    2) To parse the intersection of intrinsic and extrinsic factors with post-transcriptional regulation during neural crest and nervous system development
    3) To leverage post-transcriptional regulatory linkages controlling EMT and migration in neural crest and neural crest-derived cancers

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. "Beyond transcription: How post-transcriptional mechanisms drive neural crest EMT". Genesis. 2023 Sep 21; e23553. Guzman-Espinoza M, Kim M, Ow C, Hutchins EJ. PMID: 37735882.
      View in: PubMed   Mentions:    Fields:    
    2. Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2212879119. Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME. PMID: 36508654; PMCID: PMC9907157.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    3. RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification. Elife. 2022 10 03; 11. Hutchins EJ, Gandhi S, Chacon J, Piacentino M, Bronner ME. PMID: 36189921; PMCID: PMC9529247.
      View in: PubMed   Mentions: 1     Fields:    
    4. Essential function and targets of BMP signaling during midbrain neural crest delamination. Dev Biol. 2021 09; 477:251-261. Piacentino ML, Hutchins EJ, Bronner ME. PMID: 34102166; PMCID: PMC8277753.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT. Front Physiol. 2021; 12:624037. Hutchins EJ, Piacentino ML, Bronner ME. PMID: 33613313; PMCID: PMC7886793.
      View in: PubMed   Mentions: 4  
    6. A Spectrum of Cell States During the Epithelial-to-Mesenchymal Transition. Methods Mol Biol. 2021; 2179:3-6. Hutchins EJ, Bronner ME. PMID: 32939707.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration. Elife. 2020 09 23; 9. Gandhi S, Hutchins EJ, Maruszko K, Park JH, Thomson M, Bronner ME. PMID: 32965216; PMCID: PMC7591248.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    8. Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT. Dev Biol. 2019 02 15; 446(2):151-158. Hutchins EJ, Bronner ME. PMID: 30579765; PMCID: PMC6368465.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    9. Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT. J Cell Biol. 2018 10 01; 217(10):3683-3697. Hutchins EJ, Bronner ME. PMID: 30026247; PMCID: PMC6168252.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    10. Migration and diversification of the vagal neural crest. Dev Biol. 2018 12 01; 444 Suppl 1:S98-S109. Hutchins EJ, Kunttas E, Piacentino ML, Howard AGA, Bronner ME, Uribe RA. PMID: 29981692; PMCID: PMC6320731.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    11. A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo. Biochem Biophys Res Commun. 2016 09 16; 478(2):772-6. Hutchins EJ, Belrose JL, Szaro BG. PMID: 27501755.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Phosphorylation of heterogeneous nuclear ribonucleoprotein K at an extracellular signal-regulated kinase phosphorylation site promotes neurofilament-medium protein expression and axon outgrowth in Xenopus. Neurosci Lett. 2015 Oct 21; 607:59-65. Hutchins EJ, Belrose JL, Szaro BG. PMID: 26409787.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. c-Jun N-terminal kinase phosphorylation of heterogeneous nuclear ribonucleoprotein K regulates vertebrate axon outgrowth via a posttranscriptional mechanism. J Neurosci. 2013 Sep 11; 33(37):14666-80. Hutchins EJ, Szaro BG. PMID: 24027268; PMCID: PMC6705169.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells