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Girish Vyas, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentLaboratory Medicine
Address185 Berry St B N
San Francisco CA 94107
Phone415-353-9470
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    Collapse Biography 
    Collapse Education and Training
    University of BombayPh.D.1965Pathology, G.S. Medical College
    Royal College of PathologistsF.R.C.Path.2012Virology, Immunology, Transfusion Medicine
    Collapse Awards and Honors
    International Society of Blood Transfusion1969Jean Julliard Prize
    Pasteur Institute, Paris1980American Fulbright Visiting Scholar

    Collapse Overview 
    Collapse Overview
    Girish N. Vyas, Ph.D. (Univ. of Bombay, 1965), F.R.C.Path. (London, 2012), completed a postdoctoral fellowship at Case-WRU in Cleveland, Ohio in 1967. Then he joined UCSF School of Medicine as a Lecturer in Hematology and Immunology Unit of the Department of Medicine. He moved to Department of Laboratory Medicine as an Assistant Professor and served as Director of Blood Bank at UCSF Medical Center from 1969-89. During his sabbatical leave in 1972-73 he worked as a visiting scientist at Weizmann Institute in Israel and Walter and Eliza Hall Institute in Australia. In 1980 he got an American Fulbright Senior Scholar Award to work with Pierre Tiollais on molecular biology of HBV at the Pasteur Institute, Paris. During his four decades of faculty service at UCSF he trained 18 graduate and 46 postdoctoral scholars. His seminal contributions to our current knowledge about IgA deficiency and anaphylactic transfusion reactions, HBsAg structure, HBV vaccine and immune globulins in perinatal prevention of mother to child transmission of infection, screening and elimination of transfusion-transmitted HBV, HCV, HIV to enhance transfusion safety, and sustained commitment to immune prevention of HIV/AIDS. These contributions earned him the honor as a "Pioneer and Pathfinder in Transfusion Medicine" in 2008. He has edited 12 books and monographs and published 225 original papers. He has served on several committees of NAS-NRC, NIH, CDC, FDA, WHO, AABB, ASH, and UNDP and as the Editor-in-Chief of Biological. Currently he is an Emeritus Professor of Laboratory Medicine at UCSF and full-time CEO of TheraBiol, Inc., a start-up biotech company launched in 2012 for R&D of antibodies for prevention and treatment of persistent infections, HIV being the first target.


    Collapse Research 
    Collapse Research Activities and Funding
    IN VITRO INACTIVATION OF VIRUSES IN BLOOD COMPONENTS
    NIH/NHLBI R01HL053384Sep 30, 1994 - Aug 31, 2000
    Role: Principal Investigator
    REMOVAL/INACTIVATION OF VIRUSES IN BLOOD
    NIH/NHLBI R01HL041361Jul 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    DEVELOPMENT OF SCREENING TESTS FOR HTLV-III
    NIH/NHLBI N01HB067020Sep 30, 1986 - Sep 30, 1995
    Role: Principal Investigator
    EFFECTIVENESS OF HTLV-III ANTIBODY SCREENING
    NIH/NHLBI N01HB067024Sep 30, 1986 - Sep 30, 1995
    Role: Principal Investigator
    TRANSFUSION-RELATED VIRAL INFECTIONS AND IMMUNE RESPONSE
    NIH/NHLBI P01HL036589Jul 1, 1986 - Dec 31, 1991
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Stevens CE, Toy P, Kamili S, Taylor PE, Tong MJ, Xia GL, Vyas GN. Eradicating hepatitis B virus: The critical role of preventing perinatal transmission. Biologicals. 2017 Nov; 50:3-19. PMID: 28870397.
      View in: PubMed
    2. Busch MP, Vyas GN. Remembering James W. Mosley, MD (1929-2015), and his legacy in transfusion safety. Transfusion. 2016 Apr; 56(4):996-8. PMID: 27079314.
      View in: PubMed
    3. Killian MS, Vyas GN, Mehta R, Young K, Ebrahim O. Possible transmission of human immunodeficiency virus-1 infection from an elite controller to a patient who progressed to acquired immunodeficiency syndrome: a case report. J Med Case Rep. 2012 Sep 11; 6:291. PMID: 22967353; PMCID: PMC3469400.
    4. Pandey S, Vyas GN. Adverse effects of plasma transfusion. Transfusion. 2012 May; 52 Suppl 1:65S-79S. PMID: 22578374; PMCID: PMC3356109.
    5. Vyas GN, Grady GF. The life and legacy of Alfred M. Prince, M. D. (1928-2011). Biologicals. 2012 Jan; 40(1):1-2. PMID: 22408790.
      View in: PubMed
    6. Vyas GN, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y. Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. Biologicals. 2012 Jan; 40(1):15-20. PMID: 22192456.
      View in: PubMed
    7. Lai-Hipp C, Goldberg T, Scott E, Ziman A, Vyas G. Pooled peripheral blood mononuclear cells provide an optimized cellular substrate for human immunodeficiency virus Type 1 isolation during acute infection. Transfusion. 2011 Feb; 51(2):333-7. PMID: 20796251.
      View in: PubMed
    8. Vyas GN. Unconventional journals: research ramifications. Science. 2010 Apr 23; 328(5977):427. PMID: 20413475.
      View in: PubMed
    9. Dodd R, Kurt Roth W, Ashford P, Dax EM, Vyas G. Transfusion medicine and safety. Biologicals. 2009 Apr; 37(2):62-70. PMID: 19230706.
      View in: PubMed
    10. Stiehm ER, Keller MA, Vyas GN. Preparation and use of therapeutic antibodies primarily of human origin. Biologicals. 2008 Nov; 36(6):363-74. PMID: 18789721.
      View in: PubMed
    11. Vyas GN. Participating in the evolution of transfusion medicine from a dispensary into a discipline. Transfus Med Rev. 2008 Apr; 22(2):162-7. PMID: 18353255.
      View in: PubMed
    12. Leong M, Babbitt W, Vyas G. A hollow-fiber bioreactor for expanding HIV-1 in human lymphocytes used in preparing an inactivated vaccine candidate. Biologicals. 2007 Oct; 35(4):227-33. PMID: 17728144.
      View in: PubMed
    13. Grady GF, Vyas GN. Blood-transmitted prions and variant Creutzfeldt-Jakob disease. Biologicals. 2007 Apr; 35(2):75-7. PMID: 17317213.
      View in: PubMed
    14. Terrault NA, Vyas G. Hepatitis B immune globulin preparations and use in liver transplantation. Clin Liver Dis. 2003 Aug; 7(3):537-50. PMID: 14509525.
      View in: PubMed
    15. Blum HE, Vyas GN. Hepatitis B virus in non-hepatocytes. Lancet. 1983 Oct 15; 2(8355):920. PMID: 6137741.
      View in: PubMed
    16. Peterson DL, Roberts IM, Vyas GN. Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen. Proc Natl Acad Sci U S A. 1977 Apr; 74(4):1530-4. PMID: 266193; PMCID: PMC430823.
    17. Rao KR, Vyas GN. Biochemical characterization of hepatitis B surface antigen in relation to serologic activity. J Biol Stand. 1976; 4(4):295-304. PMID: 993216.
      View in: PubMed
    18. Roberts IM, Bernard CC, Vyas GN, Mackay IR. T-cell dependence of immune response to hepatitis B antigen in mice. Nature. 1975 Apr 17; 254(5501):606-7. PMID: 1079326.
      View in: PubMed
    19. Rao KR, Vyas GN. Hepatitis B surface antigen (HBs Ag): tryptophan content and biological activity. J Gen Virol. 1974 Sep; 24(3):571-3. PMID: 4427108.
      View in: PubMed
    20. Rao KR, Vyas GN. Structure and activity of hepatitis B antigen (HBAg). 2. Amino acid composition of an active subunit of HBAg. Microbios. 1974 May; 10(40):233-8. PMID: 4854427.
      View in: PubMed
    21. Rao KR, Vyas GN. Structure and activity of hepatitis B antigen (HBAg). 1. Studies on some conformational aspects and chemical modification of hepatitis B antigen. Microbios. 1974 Mar-Apr; 9(36):239-45. PMID: 4134655.
      View in: PubMed
    22. Rao KR, Vyas GN. Hepatitis B antigen activity in protein subunits produced by sonicaation. Nat New Biol. 1973 Feb 21; 241(112):240-1. PMID: 4512480.
      View in: PubMed
    23. Vyas GN, Rao KR, Ibrahim AB. Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds. Science. 1972 Dec 22; 178(4067):1300-1. PMID: 4118259.
      View in: PubMed
    24. Schuh V, Vyas GN, Fudenberg HH. Study of a French family with a new variant of blood group A: A lae . Am J Hum Genet. 1972 Jan; 24(1):11-7. PMID: 5012687; PMCID: PMC1762156.
    25. Faulk WP, Vyas GN, Phillips CA, Fudenberg HH, Chism K. Passive haemagglutination test for anti-rhinovirus antibodies. Nat New Biol. 1971 May 26; 231(21):101-4. PMID: 4325709.
      View in: PubMed
    26. Vyas GN, Levin AS, Fudenberg HH. Intrauterine isoimmunization caused by maternal IgA crossing the placenta. Nature. 1970 Jan 17; 225(5229):275-6. PMID: 5308068.
      View in: PubMed
    27. Vyas GN, Fudenberg HH. Am(1), the first genetic marker of human immunoglobulin A. Proc Natl Acad Sci U S A. 1969 Dec; 64(4):1211-6. PMID: 4195395; PMCID: PMC223270.
    28. Fudenberg HH, Gold ER, Vyas GN, Mackenzie MR. Human antibodies to human IgA globulins. Immunochemistry. 1968 Mar; 5(2):203-6. PMID: 4103908.
      View in: PubMed
    29. Vyas GN, Fudenberg HH, Pretty HM, Gold ER. A new rapid method for genetic typing of human immunoglobulins. J Immunol. 1968 Feb; 100(2):274-9. PMID: 4170633.
      View in: PubMed
    30. Sathe MS, Vyas GN, Bhatia HM, Purandare NM. Hemagglutinating substances in plant seeds. J Postgrad Med. 1967 Jan; 13(1):29-36. PMID: 6035742.
      View in: PubMed
    31. VYAS GN, SATHE MS, PURANDARE NM, SATOSKAR RS. RED CELL, PLASMA AND BLOOD VOLUME MEASURED BY RADIOCHROMIUM LABELLED CELLS AND HAEMATOCRIT IN INDIANS BELONGING TO LOW AND HIGH SOCIO-ECONOMIC GROUPS. Indian J Med Res. 1965 Feb; 53:122-39. PMID: 14276069.
      View in: PubMed
    32. VYAS GN, PANDIT HM, PURANDARE NM. Suppression of gene A in two cases of anti-H (Bombay bloods) in a family from South Canara. J Assoc Physicians India. 1962 Dec; 10:745-8. PMID: 13998077.
      View in: PubMed
    33. VYAS GN, BHATIA HM, SUKUMARAN PK, BALKRISHANAN V, SANGHVI LD. Study of blood groups, abnormal hemoglobins and other genetical characters in some tribes of Gujarat. Am J Phys Anthropol. 1962 Sep; 20:255-65. PMID: 13998076.
      View in: PubMed
    34. VYAS GN, BHATIA HM, BANKER DD, PURANDARE NM. Study of blood groups and other genetical characters in six Gujarati endogamous groups in Western India. Ann Hum Genet. 1958 May; 22(3):185-99. PMID: 13534204.
      View in: PubMed
    35. VYAS GN, SHAH NM. Chalkones from quinacetophenone monomethyl ether. Curr Sci. 1950 Oct; 19(10):318-9. PMID: 14792992.
      View in: PubMed
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