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Girish Vyas, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address185 Berry St B N
San Francisco CA 94107
Phone415-353-9470
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    Collapse Biography 
    Collapse Education and Training
    University of BombayPh.D.1965Pathology, G.S. Medical College
    Royal College of PathologistsF.R.C.Path.2012Virology, Immunology, Transfusion Medicine
    Collapse Awards and Honors
    International Society of Blood Transfusion1969Jean Julliard Prize
    Pasteur Institute, Paris1980American Fulbright Visiting Scholar

    Collapse Overview 
    Collapse Overview
    Girish N. Vyas, Ph.D. (Univ. of Bombay, 1965), F.R.C.Path. (London, 2012), completed a postdoctoral fellowship at Case-WRU in Cleveland, Ohio in 1967. Then he joined UCSF School of Medicine as a Lecturer in Hematology and Immunology Unit of the Department of Medicine. He moved to Department of Laboratory Medicine as an Assistant Professor and served as Director of Blood Bank at UCSF Medical Center from 1969-89. During his sabbatical leave in 1972-73 he worked as a visiting scientist at Weizmann Institute in Israel and Walter and Eliza Hall Institute in Australia. In 1980 he got an American Fulbright Senior Scholar Award to work with Pierre Tiollais on molecular biology of HBV at the Pasteur Institute, Paris. During his four decades of faculty service at UCSF he trained 18 graduate and 46 postdoctoral scholars. His seminal contributions to our current knowledge about IgA deficiency and anaphylactic transfusion reactions, HBsAg structure, HBV vaccine and immune globulins in perinatal prevention of mother to child transmission of infection, screening and elimination of transfusion-transmitted HBV, HCV, HIV to enhance transfusion safety, and sustained commitment to immune prevention of HIV/AIDS. These contributions earned him the honor as a "Pioneer and Pathfinder in Transfusion Medicine" in 2008. He has edited 12 books and monographs and published 225 original papers. He has served on several committees of NAS-NRC, NIH, CDC, FDA, WHO, AABB, ASH, and UNDP and as the Editor-in-Chief of Biological. Currently he is an Emeritus Professor of Laboratory Medicine at UCSF and full-time CEO of TheraBiol, Inc., a start-up biotech company launched in 2012 for R&D of antibodies for prevention and treatment of persistent infections, HIV being the first target.


    Collapse Research 
    Collapse Research Activities and Funding
    IN VITRO INACTIVATION OF VIRUSES IN BLOOD COMPONENTS
    NIH/NHLBI R01HL053384Sep 30, 1994 - Aug 31, 2000
    Role: Principal Investigator
    REMOVAL/INACTIVATION OF VIRUSES IN BLOOD
    NIH/NHLBI R01HL041361Jul 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    DEVELOPMENT OF SCREENING TESTS FOR HTLV-III
    NIH/NHLBI N01HB067020Sep 30, 1986 - Sep 30, 1995
    Role: Principal Investigator
    EFFECTIVENESS OF HTLV-III ANTIBODY SCREENING
    NIH/NHLBI N01HB067024Sep 30, 1986 - Sep 30, 1995
    Role: Principal Investigator
    TRANSFUSION-RELATED VIRAL INFECTIONS AND IMMUNE RESPONSE
    NIH/NHLBI P01HL036589Jul 1, 1986 - Dec 31, 1991
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Busch MP, Vyas G. Remembering James W. Mosley, MD (1929-2015), and his legacy in transfusion safety. Transfusion. 2016 Apr; 56(4):996-8. PMID: 27079314.
      View in: PubMed
    2. Killian MS, Vyas G, Mehta R, Young K, Ebrahim O. Possible transmission of human immunodeficiency virus-1 infection from an elite controller to a patient who progressed to acquired immunodeficiency syndrome: a case report. J Med Case Rep. 2012; 6:291. PMID: 22967353; PMCID: PMC3469400.
      View in: PubMed, PubMed Central
    3. Pandey S, Vyas G. Adverse effects of plasma transfusion. Transfusion. 2012 May; 52 Suppl 1:65S-79S. PMID: 22578374; PMCID: PMC3356109.
      View in: PubMed, PubMed Central
    4. Vyas G, Grady GF. The life and legacy of Alfred M. Prince, M. D. (1928-2011). Biologicals. 2012 Jan; 40(1):1-2. PMID: 22408790.
      View in: PubMed
    5. Vyas G, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y. Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. Biologicals. 2012 Jan; 40(1):15-20. PMID: 22192456.
      View in: PubMed
    6. Lai-Hipp C, Goldberg T, Scott E, Ziman A, Vyas G. Pooled peripheral blood mononuclear cells provide an optimized cellular substrate for human immunodeficiency virus Type 1 isolation during acute infection. Transfusion. 2011 Feb; 51(2):333-7. PMID: 20796251.
      View in: PubMed
    7. Vyas G. Unconventional journals: research ramifications. Science. 2010 Apr 23; 328(5977):427. PMID: 20413475.
      View in: PubMed
    8. Dodd R, Kurt Roth W, Ashford P, Dax EM, Vyas G. Transfusion medicine and safety. Biologicals. 2009 Apr; 37(2):62-70. PMID: 19230706.
      View in: PubMed
    9. Stiehm ER, Keller MA, Vyas G. Preparation and use of therapeutic antibodies primarily of human origin. Biologicals. 2008 Nov; 36(6):363-74. PMID: 18789721.
      View in: PubMed
    10. Vyas G. Participating in the evolution of transfusion medicine from a dispensary into a discipline. Transfus Med Rev. 2008 Apr; 22(2):162-7. PMID: 18353255; PMCID: PMC2361154.
      View in: PubMed, PubMed Central
    11. Leong M, Babbitt W, Vyas G. A hollow-fiber bioreactor for expanding HIV-1 in human lymphocytes used in preparing an inactivated vaccine candidate. Biologicals. 2007 Oct; 35(4):227-33. PMID: 17728144.
      View in: PubMed
    12. Grady GF, Vyas G. Blood-transmitted prions and variant Creutzfeldt-Jakob disease. Biologicals. 2007 Apr; 35(2):75-7. PMID: 17317213.
      View in: PubMed
    13. Terrault NA, Vyas G. Hepatitis B immune globulin preparations and use in liver transplantation. Clin Liver Dis. 2003 Aug; 7(3):537-50. PMID: 14509525.
      View in: PubMed
    14. Vyas G. Human peripheral blood mononuclear cell substrate for propagating wild type HIV-1. Dev Biol (Basel). 2001; 106:345-56; discussion 356-7. PMID: 11761248.
      View in: PubMed
    15. Gandhi MJ, Yang GG, McMahon BJ, Vyas G. Hepatitis B virions isolated with antibodies to the pre-S1 domain reveal occult viremia by PCR in Alaska Native HBV carriers who have seroconverted. Transfusion. 2000 Aug; 40(8):910-6. PMID: 10960516.
      View in: PubMed
    16. Vyas G. Immunobiology of persistent blood-borne viral infections. Dev Biol (Basel). 2000; 102:9-17. PMID: 10794086.
      View in: PubMed
    17. Gandhi MJ, Boyd MR, Yi L, Yang GG, Vyas G. Properties of cyanovirin-N (CV-N): inactivation of HIV-1 by sessile cyanovirin-N (sCV-N). Dev Biol (Basel). 2000; 102:141-8. PMID: 10794101.
      View in: PubMed
    18. Murphy EL, Busch MP, Tong M, Cornett P, Vyas G. A prospective study of the risk of transfusion-acquired viral infections. Transfus Med. 1998 Sep; 8(3):173-8. PMID: 9800288.
      View in: PubMed
    19. Yang G, D'Souza MP, Vyas G. Neutralizing antibodies against HIV determined by amplification of viral long terminal repeat sequences from cells infected in vitro by nonneutralized virions. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1; 17(1):27-34. PMID: 9436755.
      View in: PubMed
    20. Dorenbaum A, Venkateswaran KS, Yang G, Comeau AM, Wara D, Vyas G. Transmission of HIV-1 in infants born to seropositive mothers: PCR-amplified proviral DNA detected by flow cytometric analysis of immunoreactive beads. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 May 1; 15(1):35-42. PMID: 9215652.
      View in: PubMed
    21. Gelb AB, Venkateswaran KS, Vyas G. Editorial summary of the Pre-symposium workshop on the Contemporary Assessment of Technologies. Biologicals. 1996 Sep; 24(3):177-86. PMID: 8978914.
      View in: PubMed
    22. Rawal BD, Vyas G. Magnesium-mediated reversal of the apparent virucidal effect of ascorbic acid or congo red reacted in vitro with the human immunodeficiency virus. Biologicals. 1996 Jun; 24(2):113-6. PMID: 8889057.
      View in: PubMed
    23. Yang G, Vyas G. Immunodiagnosis of viral hepatitides A to E and non-A to -E. Clin Diagn Lab Immunol. 1996 May; 3(3):247-56. PMID: 8705663; PMCID: PMC170322.
      View in: PubMed, PubMed Central
    24. Vyas G, Rawal BD. The risk of HIV transmission by screened blood. N Engl J Med. 1996 Apr 11; 334(15):992; author reply 993. PMID: 8596612.
      View in: PubMed
    25. Prati D, Brandwein H, Capelli C, Dzik WH, Masse M, Myllylä G, Stromberg RR, Takahashi T, Vyas G, Wenz B. Multicenter evaluation of the 3% paraformaldehyde method for white cell counting in leukocyte-reduced red blood cells. BEST (Biomedical Excellence for Safer Transfusion) Working Party of the International Society of Blood Transfusion. Vox Sang. 1996; 70(4):241-5. PMID: 9123935.
      View in: PubMed
    26. Yang G, Olson JC, Pu R, Vyas G. Flow cytometric detection of human immunodeficiency virus type 1 proviral DNA by the polymerase chain reaction incorporating digoxigenin- or fluorescein-labeled dUTP. Cytometry. 1995 Oct 1; 21(2):197-202. PMID: 8582240.
      View in: PubMed
    27. Vyas G. Inactivation and removal of blood-borne viruses. Transfusion. 1995 May; 35(5):367-70. PMID: 7740604.
      View in: PubMed
    28. Prati D, Rawal BD, Dang C, Capelli C, Vyas G. DNA enzyme immunoassay of the PCR-amplified HLA-DQ alpha gene for estimating residual leukocytes in filtered blood. Clin Diagn Lab Immunol. 1995 Mar; 2(2):182-5. PMID: 7697526; PMCID: PMC170124.
      View in: PubMed, PubMed Central
    29. Rawal BD, Bartolini F, Vyas G. In vitro inactivation of human immunodeficiency virus by ascorbic acid. Biologicals. 1995 Mar; 23(1):75-81. PMID: 7619441.
      View in: PubMed
    30. Vyas G, Yang G, Murphy EL. Transfusion-related transmissible diseases: detection by polymerase chain reaction-amplified genes of the microbial agents. Transfus Med Rev. 1994 Oct; 8(4):253-66. PMID: 7841669.
      View in: PubMed
    31. Sankary TM, Yang G, Romeo JM, Ulrich PP, Busch MP, Rawal BD, Vyas G. Rare detection of hepatitis B and hepatitis C virus genomes by polymerase chain reaction in seronegative donors with elevated alanine aminotransferase. Transfusion. 1994 Aug; 34(8):656-60. PMID: 8073480.
      View in: PubMed
    32. Yang G, Garhwal S, Olson JC, Vyas G. Flow cytometric immunodetection of human immunodeficiency virus type 1 proviral DNA by heminested PCR and digoxigenin-labeled probes. Clin Diagn Lab Immunol. 1994 Jan; 1(1):26-31. PMID: 7496917; PMCID: PMC368191.
      View in: PubMed, PubMed Central
    33. Gong J, Rawal BD, Högman CF, Vyas G, Nilsson B, Gustafsson I. Complement killing of Yersinia enterocolitica and retention of the bacteria by leucocyte removal filters. Vox Sang. 1994; 66(3):166-70. PMID: 8036784.
      View in: PubMed
    34. Babu PG, Rawal BD, Khayam-Bashi H, Vyas G. Detection of exceedingly low levels of HIV proviral DNA in multimillion peripheral blood mononuclear cells by PCR. PCR Methods Appl. 1993 Aug; 3(1):63-4. PMID: 8220187.
      View in: PubMed
    35. Rawal BD, Vyas G. Complement-mediated bactericidal action and the removal of Yersinia enterocolitica by white cell filters. Transfusion. 1993 Jun; 33(6):536. PMID: 8516801.
      View in: PubMed
    36. Vyas G. Molecular approaches to the detection of agents in persistent viral infections. Indian J Med Sci. 1993 Apr; 47(4):103-8. PMID: 7689072.
      View in: PubMed
    37. Yang G, Ulrich PP, Aiyer RA, Rawal BD, Vyas G. Detection of hepatitis B virus in plasma using flow cytometric analyses of polymerase chain reaction-amplified DNA incorporating digoxigenin-11-dUTP. Blood. 1993 Feb 15; 81(4):1083-8. PMID: 8427989.
      View in: PubMed
    38. Romeo JM, Ulrich PP, Busch MP, Vyas G. Analysis of hepatitis C virus RNA prevalence and surrogate markers of infection among seropositive voluntary blood donors. Hepatology. 1993 Feb; 17(2):188-95. PMID: 8381382.
      View in: PubMed
    39. Ulrich PP, Romeo JM, Daniel LJ, Vyas G. An improved method for the detection of hepatitis C virus RNA in plasma utilizing heminested primers and internal control RNA. PCR Methods Appl. 1993 Feb; 2(3):241-9. PMID: 7680265.
      View in: PubMed
    40. Eble BE, Busch MP, Khayam-Bashi H, Nason MA, Samson S, Vyas G. Resolution of infection status of human immunodeficiency virus (HIV)-seroindeterminate donors and high-risk seronegative individuals with polymerase chain reaction and virus culture: absence of persistent silent HIV type 1 infection in a high-prevalence area. Transfusion. 1992 Jul-Aug; 32(6):503-8. PMID: 1502702.
      View in: PubMed
    41. Romeo JM, Ulrich PP, Vyas G. Hepatitis C virus detection in blood donors. Transfusion. 1991 Oct; 31(8):780. PMID: 1656554.
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    42. Busch MP, Eble BE, Khayam-Bashi H, Heilbron D, Murphy EL, Kwok S, Sninsky J, Perkins HA, Vyas G. Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells. N Engl J Med. 1991 Jul 4; 325(1):1-5. PMID: 2046708.
      View in: PubMed
    43. Weintrub PS, Ulrich PP, Edwards JR, Boucher F, Levy JA, Cowan MJ, Vyas G. Use of polymerase chain reaction for the early detection of HIV infection in the infants of HIV-seropositive women. AIDS. 1991 Jul; 5(7):881-4. PMID: 1892594.
      View in: PubMed
    44. Lee HS, Ulrich PP, Vyas G. Mutations in the S-gene affecting the immunologic determinants of the envelope protein of hepatitis B virus. J Hepatol. 1991; 13 Suppl 4:S97-101. PMID: 1726591.
      View in: PubMed
    45. Rawal B, Yen TS, Vyas G, Busch M. Leukocyte filtration removes infectious particulate debris but not free virus derived from experimentally lysed HIV-infected cells. Vox Sang. 1991; 60(4):214-8. PMID: 1926828.
      View in: PubMed
    46. Rawal BD, Schwadron R, Busch MP, Endow R, Vyas G. Evaluation of leukocyte removal filters modelled by use of HIV-infected cells and DNA amplification. Blood. 1990 Nov 15; 76(10):2159-61. PMID: 2242434.
      View in: PubMed
    47. Ulrich PP, Romeo JM, Lane PK, Kelly I, Daniel LJ, Vyas G. Detection, semiquantitation, and genetic variation in hepatitis C virus sequences amplified from the plasma of blood donors with elevated alanine aminotransferase. J Clin Invest. 1990 Nov; 86(5):1609-14. PMID: 2173725; PMCID: PMC296910.
      View in: PubMed, PubMed Central
    48. Vyas G. [Effective use of hepatitis tests]. Taehan Kanho. 1990 Oct 31; 29(4):38-43. PMID: 2125092.
      View in: PubMed
    49. Rawal BD, Davis RE, Busch MP, Vyas G. Dual reduction in the immunologic and infectious complications of transfusion by filtration/removal of leukocytes from donor blood soon after collection. Transfus Med Rev. 1990 Oct; 4(4 Suppl 1):36-41. PMID: 2134639.
      View in: PubMed
    50. Ulrich PP, Bhat RA, Kelly I, Brunetto MR, Bonino F, Vyas G. A precore-defective mutant of hepatitis B virus associated with e antigen-negative chronic liver disease. J Med Virol. 1990 Oct; 32(2):109-18. PMID: 2280256.
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    51. Bhat RA, Ulrich PP, Vyas G. Molecular characterization of a new variant of hepatitis B virus in a persistently infected homosexual man. Hepatology. 1990 Feb; 11(2):271-6. PMID: 2307406.
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    52. Roy S, Morrow WJ, Christian C, Khayam-Bashi H, Busch MP, McCarthy R, Rodgers RP, Vyas G. Persistent immune complexes and abnormal CD4/CD8 ratios in HIV infection. J Acquir Immune Defic Syndr. 1990; 3(2):134-8. PMID: 1967308.
      View in: PubMed
    53. Lee HS, Sarosi I, Vyas G. Aflatoxin B1 formamidopyrimidine adducts in human hepatocarcinogenesis: a preliminary report. Gastroenterology. 1989 Nov; 97(5):1281-7. PMID: 2551766.
      View in: PubMed
    54. Edwards JR, Ulrich PP, Weintrub PS, Cowan MJ, Levy JA, Wara DW, Vyas G. Polymerase chain reaction compared with concurrent viral cultures for rapid identification of human immunodeficiency virus infection among high-risk infants and children. J Pediatr. 1989 Aug; 115(2):200-3. PMID: 2754549.
      View in: PubMed
    55. Ulrich PP, Bhat RA, Seto B, Mack D, Sninsky J, Vyas G. Enzymatic amplification of hepatitis B virus DNA in serum compared with infectivity testing in chimpanzees. J Infect Dis. 1989 Jul; 160(1):37-43. PMID: 2732516.
      View in: PubMed
    56. Rawal BD, Busch MP, Endow R, Garcia-de-Lomas J, Perkins HA, Schwadron R, Vyas G. Reduction of human immunodeficiency virus-infected cells from donor blood by leukocyte filtration. Transfusion. 1989 Jun; 29(5):460-2. PMID: 2734825.
      View in: PubMed
    57. Scillian JJ, McHugh TM, Busch MP, Tam M, Fulwyler MJ, Chien DY, Vyas G. Early detection of antibodies against rDNA-produced HIV proteins with a flow cytometric assay. Blood. 1989 May 15; 73(7):2041-8. PMID: 2540862.
      View in: PubMed
    58. Blum HE, Gerok W, Vyas G. The molecular biology of hepatitis B virus. Trends Genet. 1989 May; 5(5):154-8. PMID: 2547259.
      View in: PubMed
    59. Hwang LY, Beasley RP, Busch MP, Lane PK, Vyas G. Human immunodeficiency virus seroprevalence among blood product recipients in San Francisco before transfusion. Transfusion. 1989 Feb; 29(2):113-8. PMID: 2919421.
      View in: PubMed
    60. Lai ME, Farci P, Figus A, Balestrieri A, Arnone M, Vyas G. Hepatitis B virus DNA in the serum of Sardinian blood donors negative for the hepatitis B surface antigen. Blood. 1989 Jan; 73(1):17-9. PMID: 2910356.
      View in: PubMed
    61. Vyas G. Other virus infections in AIDS. IV. AIDS and hepatitis B virus infection. Immunol Ser. 1989; 44:564-7. PMID: 2489123.
      View in: PubMed
    62. Vyas G. Symposium on transfusion-associated infections and immune response. Transfus Med Rev. 1988 Dec; 2(4):193-5. PMID: 2980087.
      View in: PubMed
    63. Oexle K, Bhat RA, Vyas G. Biology of hepatitis delta virus. Transfus Med Rev. 1988 Dec; 2(4):221-3. PMID: 2980090.
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    64. Lee HS, Rajagopalan MS, Vyas G. A lack of direct role of hepatitis B virus in the activation of ras and c-myc oncogenes in human hepatocellular carcinogenesis. Hepatology. 1988 Sep-Oct; 8(5):1116-20. PMID: 2843452.
      View in: PubMed
    65. Calman AF, Busch MP, Vyas G, McHugh TM, Stites DP, Peterlin BM. Transcription and replication of human immunodeficiency virus-1 in B lymphocytes in vitro. AIDS. 1988 Jun; 2(3):185-93. PMID: 2840098.
      View in: PubMed
    66. Ulrich PP, Busch MP, el-Beik T, Shiota J, Vennari J, Shriver K, Vyas G. Assessment of human immunodeficiency virus expression in cocultures of peripheral blood mononuclear cells from healthy seropositive subjects. J Med Virol. 1988 May; 25(1):1-10. PMID: 3411308.
      View in: PubMed
    67. Gjerset GF, Vyas G, Bhat R, Operskalski EA. Phenotypes for group-specific component among patients exposed to human immunodeficiency virus by transfusions. J Infect Dis. 1988 Mar; 157(3):609-10. PMID: 3343536.
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    68. Lee HS, Vyas G. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-57. PMID: 3319367.
      View in: PubMed
    69. Busch MP, Rajagopalan MS, Gantz DM, Fu S, Steimer KS, Vyas G. In situ hybridization and immunocytochemistry for improved assessment of human immunodeficiency virus cultures. Am J Clin Pathol. 1987 Dec; 88(6):673-80. PMID: 3318386.
      View in: PubMed
    70. Stevens CE, Taylor PE, Tong MJ, Toy PT, Vyas G, Nair PV, Weissman JY, Krugman S. Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis B immune globulin in prevention of perinatal hepatitis B virus transmission. JAMA. 1987 May 15; 257(19):2612-6. PMID: 2952812.
      View in: PubMed
    71. Lee HS, Rajagopalan MS, Chien D, Cordell R, Perkins HA, Vyas G. Specificity of enzyme immunoassay for hepatitis B core antibody used in screening blood donors. Transfusion. 1987 Jan-Feb; 27(1):103-6. PMID: 3544369.
      View in: PubMed
    72. Rajagopalan MS, Busch MP, Blum HE, Vyas G. Interaction of aflatoxin and hepatitis B virus in the pathogenesis of hepatocellular carcinoma. Life Sci. 1986 Oct 6; 39(14):1287-90. PMID: 3020328.
      View in: PubMed
    73. Stevens CE, Taylor PE, Tong MJ, Toy PT, Vyas G. Yeast recombinant hepatitis B vaccine in perinatal hepatitis B virus transmission: a preliminary report. J Infect. 1986 Jul; 13 Suppl A:13. PMID: 2943810.
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    74. Vyas G. A brief overview of the new vaccines against hepatitis B virus infection: immunogenic gene products and peptide analogues of antigenic epitopes. Dev Biol Stand. 1986; 63:141-6. PMID: 2427376.
      View in: PubMed
    75. Stevens CE, Toy PT, Tong MJ, Taylor PE, Vyas G, Nair PV, Gudavalli M, Krugman S. Perinatal hepatitis B virus transmission in the United States. Prevention by passive-active immunization. JAMA. 1985 Mar 22-29; 253(12):1740-5. PMID: 3974052.
      View in: PubMed
    76. Blum HE, Figus A, Haase AT, Vyas G. Laboratory diagnosis of hepatitis B virus infection by nucleic acid hybridization analyses and immunohistologic detection of gene products. Dev Biol Stand. 1985; 59:125-39. PMID: 4007272.
      View in: PubMed
    77. Blum HE, Haase AT, Harris JD, Walker D, Vyas G. Asymmetric replication of hepatitis B virus DNA in human liver: demonstration of cytoplasmic minus-strand DNA by blot analyses and in situ hybridization. Virology. 1984 Nov; 139(1):87-96. PMID: 6495661.
      View in: PubMed
    78. Blum HE, Haase AT, Vyas G. Molecular pathogenesis of hepatitis B virus infection: simultaneous detection of viral DNA and antigens in paraffin-embedded liver sections. Lancet. 1984 Oct 6; 2(8406):771-5. PMID: 6148521.
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    79. Vyas G, Blum HE. Hepatitis B virus infection. Current concepts of chronicity and immunity. West J Med. 1984 May; 140(5):754-62. PMID: 6328774; PMCID: PMC1011082.
      View in: PubMed, PubMed Central
    80. Figus A, Blum HE, Vyas G, De Virgilis S, Cao A, Lippi M, Lai E, Balestrieri A. Hepatitis B viral nucleotide sequences in non-A, non-B or hepatitis B virus-related chronic liver disease. Hepatology. 1984 May-Jun; 4(3):364-8. PMID: 6327483.
      View in: PubMed
    81. Blum HE, Stowring L, Figus A, Montgomery CK, Haase AT, Vyas G. Detection of hepatitis B virus DNA in hepatocytes, bile duct epithelium, and vascular elements by in situ hybridization. Proc Natl Acad Sci U S A. 1983 Nov; 80(21):6685-8. PMID: 6579553; PMCID: PMC391235.
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    82. Blum HE, Vyas G. Hepatitis B virus in non-hepatocytes. Lancet. 1983 Oct 15; 2(8355):920. PMID: 6137741.
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    83. Ganem D, Vyas G. Laboratory diagnosis of viral hepatitis. Geriatrics. 1983 Mar; 38(3):97-103, 107-8. PMID: 6402417.
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    84. Vyas G, Bhatnagar PK, Blum HE, Expose J, Heldebrandt CM. Appraisal and prospects of a dimeric synthetic peptide coupled with tetanus toxoid for a bifunctional vaccine against hepatitis B virus infection. Dev Biol Stand. 1983; 54:93-102. PMID: 6197328.
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    85. Bhatnagar PK, Papas E, Blum HE, Milich DR, Nitecki D, Karels MJ, Vyas G. Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant. Proc Natl Acad Sci U S A. 1982 Jul; 79(14):4400-4. PMID: 6181506; PMCID: PMC346679.
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    86. Vyas G, Perkins HA. Non-B post-transfusion hepatitis associated with hepatitis B core antibodies in donor blood. N Engl J Med. 1982 Mar 25; 306(12):749-50. PMID: 6801510.
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    87. Blum HE, Vyas G. Non-A, non-B hepatitis: a contemporary assessment. Haematologia (Budap). 1982; 15(2):153-73. PMID: 6819208.
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    88. Milich DR, Gottfried TD, Vyas G. Characterization of the interaction between polymerized human albumin and hepatitis B surface antigen. Gastroenterology. 1981 Aug; 81(2):218-25. PMID: 6165643.
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    89. Tiollais P, Charnay P, Vyas G. Biology of hepatitis B virus. Science. 1981 Jul 24; 213(4506):406-11. PMID: 6264599.
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    90. Bréchot C, Hadchouel M, Scotto J, Fonck M, Potet F, Vyas G, Tiollais P. State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3906-10. PMID: 6267609; PMCID: PMC319682.
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    91. Chien MC, Tong MJ, Lo KJ, Lee JK, Milich DR, Vyas G, Murphy BL. Hepatitis B viral markers in patients with primary hepatocellular carcinoma in Taiwan. J Natl Cancer Inst. 1981 Mar; 66(3):475-9. PMID: 6162990.
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    92. Baxi AJ, Bhatia HM, Dutta RN, John TJ, Joshi SH, Kulkarni KV, Nayak NC, Pal SR, Vyas G. Comparative data on the detection of hepatitis-B surface antigen by six centres. Indian J Med Res. 1981 Feb; 73:255-7. PMID: 7239608.
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    93. Milich DR, Bhatnagar PK, Papas ED, Vyas G. Interactions between polymerized human albumin, hepatitis B surface antigen, and complement: II. Involvement of Clq in or near the hepatitis B surface antigen receptor for polyalbumin. J Med Virol. 1981; 7(3):193-204. PMID: 6270277.
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    94. Milich DR, Papas ED, Bhatnagar PK, Vyas G. Interactions between polymerized human albumin, hepatitis B surface antigen, and complement: I. Binding of polyalbumin to Clq. J Med Virol. 1981; 7(3):181-92. PMID: 6169799.
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    95. Milich DR, Vyas G, Holland PV, Couroucé-Pauty AM, Sampliner RE. Plasmapheresis of hepatitis B surface antigen carriers. Acta Haematol Pol. 1980 Apr-Jun; 11(2):73-8. PMID: 7424484.
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    96. Tong MJ, Weiner JM, Ashcavai MW, Vyas G. Evidence for clustering of hepatitis B virus infection in families of patients with primary hepatocellular carcinoma. Cancer. 1979 Dec; 44(6):2338-4. PMID: 228843.
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    97. Tong MJ, Weiner JM, Ashcavai MW, Redeker AG, Comparini S, Vyas G. A comparative study of hepatitis B viral markers in the family members of Asian and non-Asian patients with hepatitis B surface antigen-positive hepatocellular carcinoma and with chronic hepatitis B infection. J Infect Dis. 1979 Oct; 140(4):506-12. PMID: 229173.
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    98. Chien DY, Vyas G. Correlation of the hepatitis B surface and e antigens. N Engl J Med. 1978 Nov 30; 299(22):1253-4. PMID: 714087.
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    99. Grady GF, Lee VA, Prince AM, Gitnick GL, Fawaz KA, Vyas G, Levitt MD, Senior JR, Galambos JT, Bynum TE, Singleton JW, Clowdus BF, Akdamar K, Aach RD, Winkelman EI, Schiff GM, Hersh T. Hepatitis B immune globulin for accidental exposures among medical personnel: final report of a multicenter controlled trial. J Infect Dis. 1978 Nov; 138(5):625-38. PMID: 361899.
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    100. Prince AM, Szmuness W, Mann MK, Vyas G, Grady GF, Shapiro FL, Suki WN, Freidman EA, Avram MM, Stenzel KH. Hepatitis B immune globulin: final report of a controlled, multicenter trial of efficacy in prevention of dialysis-associated hepatitis. J Infect Dis. 1978 Feb; 137(2):131-44. PMID: 342639.
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    101. Tanno H, Fay O, Findor J, Igartua EB, Roncoroni M, Gerety RJ, Vyas G. The role of the hepatitis B virus infection in patients with chronic hepatitis in Argentina. J Med Virol. 1978; 3(2):119-23. PMID: 731225.
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    102. Vyas G, Peterson DL, Townsend RM, Damle SR, Magnius LO. Hepatitis B "e" antigen: an apparent association with lactate dehydrogenase isozyme-5. Science. 1977 Dec 9; 198(4321):1068-70. PMID: 73221.
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    103. Vyas G, Roberts IM. Radioimmunoassay of hepatitis B core antigen and antibody with autologous reagents. Vox Sang. 1977 Dec; 33(6):369-72. PMID: 930050.
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    104. Grady GF, Kaplan MM, Vyas G. Antibody to hepatitis B core antigen in chronic hepatitis and primary biliary cirrhosis: evaluation by a new autologous solid phase radioimmunoassay. Gastroenterology. 1977 Apr; 72(4 Pt 1):590-3. PMID: 838211.
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    105. Peterson DL, Roberts IM, Vyas G. Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen. Proc Natl Acad Sci U S A. 1977 Apr; 74(4):1530-4. PMID: 266193; PMCID: PMC430823.
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    106. Vyas G, Roberts I, Peterson DL, Holland PV. Nonspecific test reaction for antibodies to hepatitis B surface antigen in chronic HBAg carriers. J Lab Clin Med. 1977 Feb; 89(2):428-32. PMID: 833479.
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    107. Vyas G, Perkins HA. Letter: Anti-IgA in blood donors. Transfusion. 1976 May-Jun; 16(3):289-90. PMID: 1084605.
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    108. Rao KR, Vyas G. Biochemical characterization of hepatitis B surface antigen in relation to serologic activity. J Biol Stand. 1976; 4(4):295-304. PMID: 993216.
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    109. Prince AM, Szmuness W, Mann MK, Vyas G, Grady GF, Shapiro FL, Suki WN, Friedman EA, Stenzel KH. Hepatitis B "immune" globulin: effectiveness in prevention of dialysis-associated hepatitis. N Engl J Med. 1975 Nov 20; 293(21):1063-7. PMID: 1101066.
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    110. Vyas G, Roberts I, MacKay IR, Gust ID. Immunologic mechanisms in hepatitis B assayed by antigen-binding lymphocytes. Am J Med Sci. 1975 Sep-Oct; 270(2):241-6. PMID: 1235466.
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    111. Magnius L, Kaplan L, Vyas G, Perkins HA. A new virus specified determinant of hepatitis B surface antigen. Acta Pathol Microbiol Scand B. 1975 Jun; 83(3):295-7. PMID: 50717.
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    112. Vyas G, Perkins HA, Yang YM, Basantani GK. Healthy blood donors with selective absence of immunoglobulin A: prevention of anaphylactic transfusion reactions caused by antibodies to IgA. J Lab Clin Med. 1975 May; 85(5):838-42. PMID: 804531.
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    113. Roberts IM, Bernard CC, Vyas G, Mackay IR. T-cell dependence of immune response to hepatitis B antigen in mice. Nature. 1975 Apr 17; 254(5501):606-7. PMID: 1079326.
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    114. Vyas G, Basantani GK, Perkins HA. Letter: Hepatitis in selective IgA deficiency? Br Med J. 1975 Mar 29; 1(5960):736. PMID: 1125687; PMCID: PMC1672693.
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    115. Vyas G, Schmid R, Ibrahim AB, Rao KR. Specific immunotherapy proposed for hepatitis B virus infection. Dev Biol Stand. 1975; 30:350-6. PMID: 1204970.
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    116. Ibrahim AB, Vyas G, Perkins HA. Immune response to hepatitis B surface antigen. Infect Immun. 1975 Jan; 11(1):137-41. PMID: 1116872; PMCID: PMC415036.
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    117. Greeman RL, Robinson WS, Vyas G. A sensitive test for antibody against the hepatitis B core antigen (anti-HB-c). Vox Sang. 1975; 29(1):77-80. PMID: 1170690.
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    118. Rao KR, Vyas G. Hepatitis B surface antigen (HBs Ag): tryptophan content and biological activity. J Gen Virol. 1974 Sep; 24(3):571-3. PMID: 4427108.
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    119. Vyas G, Ibrahim AB, Rao KR, Schmid R. Tolerance to hepatitis B antigen: a hypothesis for its termination with 'immune-RNA'. Life Sci. 1974 Jul 15; 15(2):261-6. PMID: 4549917.
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    120. Ibrahim AB, Vyas G, Prince AM. Studies on delayed hypersensitivity to hepatitis B antigen in chimpanzees. Clin Exp Immunol. 1974 Jun; 17(2):311-8. PMID: 4466604; PMCID: PMC1554027.
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    121. Rao KR, Vyas G. Structure and activity of hepatitis B antigen (HBAg). 2. Amino acid composition of an active subunit of HBAg. Microbios. 1974 May; 10(40):233-8. PMID: 4854427.
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    122. Perkins HA, Perkins SL, Vyas G. Further evaluation of a latex agglutination test for detection of hepatitis B antigen. Transfusion. 1974 May-Jun; 14(3):287-90. PMID: 4835955.
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    123. Vyas G. Evidence against recessive inheritance of susceptibility to the chronic carrier state for hepatitis B antigen. Nature. 1974 Mar 8; 248(5444):159-60. PMID: 4818920.
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    124. Rao KR, Vyas G. Structure and activity of hepatitis B antigen (HBAg). 1. Studies on some conformational aspects and chemical modification of hepatitis B antigen. Microbios. 1974 Mar-Apr; 9(36):239-45. PMID: 4134655.
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    125. Szmuness W, Prince AM, Grady GF, Mann MK, Levine RW, Friedman EA, Jacobs MJ, Josephson A, Ribot S, Shapiro FL, Stenzel KH, Suki WN, Vyas G. Hepatitis B infection. A point-prevalence study in 15 US hemodialysis centers. JAMA. 1974 Feb 25; 227(8):901-6. PMID: 4405860.
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    126. Vyas G, Ibrahim AB, Rao KR, Likhite V. In vitro transfer of cell-mediated immunity to hepatitis B antigen with RNA. Nature. 1974 Feb 8; 247(5440):377-8. PMID: 4817858.
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    127. Berg JV, Berntsen KO, Björling H, Holmström B, Vyas G. Recovery of hepatitis B antibody from human plasma products separated by a modified Cohn fractionation. Vox Sang. 1974; 27(4):302-9. PMID: 4213354.
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    128. Vyas G, Adelberg SG, Perkins HA. Letter: Nonspecificity of hepatitis B antigen detected with iodine-125-labeled antibody. Science. 1973 Dec 28; 182(4119):1368-71. PMID: 4796789.
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    129. Ibrahim AB, Vyas G. A simple inexpensive method for demonstrating in vitro leukocyte migration. Vox Sang. 1973 Dec; 25(6):552-6. PMID: 4798392.
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    130. Rao KR, Vyas G. Hepatitis B antigen activity in protein subunits produced by sonicaation. Nat New Biol. 1973 Feb 21; 241(112):240-1. PMID: 4512480.
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    131. Vyas G, Rao KR, Ibrahim AB. Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds. Science. 1972 Dec 22; 178(4067):1300-1. PMID: 4118259.
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    132. Pai MK, Zipursky A, Vyas G. Antibodies to IGA in pregnancy and in recipient of Rh o (D) immune globulin (human). Transfusion. 1972 Nov-Dec; 12(6):394-9. PMID: 4629999.
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    133. Vyas G. Hepatitis B antigen and antibodies: detection by hemagglutination assay. Am J Med Technol. 1972 Sep; 38(9):366-9. PMID: 5078845.
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    134. Vyas G, Williams EW, Klaus GG, Bond HE. Hepatitis-associated Australia antigen. Protein, peptides and amine acid composition of purified antigen with its use in determining sensitivity of the hemagglutination test. J Immunol. 1972 Apr; 108(4):1114-8. PMID: 5023172.
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    135. Schuh V, Vyas G, Fudenberg HH. Study of a French family with a new variant of blood group A: A lae . Am J Hum Genet. 1972 Jan; 24(1):11-7. PMID: 5012687; PMCID: PMC1762156.
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    136. Shaffer WE, Vyas G, Shahed A, Chen E, Perkins HA. Comparison of counterelectrophoresis and hemagglutination inhibition tests for hepatitis-associated antigen. Vox Sang. 1972; 22(4):366-70. PMID: 5063092.
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    137. Faulk WP, Vyas G, Phillips CA, Fudenberg HH, Chism K. Passive haemagglutination test for anti-rhinovirus antibodies. Nat New Biol. 1971 May 26; 231(21):101-4. PMID: 4325709.
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    138. Leikola J, Fudenberg HH, Vyas G, Perkins HA. Isoantibodies to human IgM: serologic and immunochemical investigations. J Immunol. 1971 May; 106(5):1147-53. PMID: 4995748.
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    139. Leikola J, Vyas G. Human antibodies to ruminant IgM concealing the absence of IgA in man. J Lab Clin Med. 1971 Apr; 77(4):629-38. PMID: 4995123.
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    140. Vyas G, Shulman NR. Hemagglutination assay for antigen and antibody associated with viral hepatitis. Science. 1970 Oct 16; 170(3955):332-3. PMID: 4990052.
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    141. Vyas G, Levin AS, Fudenberg HH. Intrauterine isoimmunization caused by maternal IgA crossing the placenta. Nature. 1970 Jan 17; 225(5229):275-6. PMID: 5308068.
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    142. Vyas G, Fudenberg HH. Am(1), the first genetic marker of human immunoglobulin A. Proc Natl Acad Sci U S A. 1969 Dec; 64(4):1211-6. PMID: 4195395; PMCID: PMC223270.
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    143. Vyas G, Holmdahl L, Perkins HA, Fudenberg HH. Serologic specificity of hun anti-IgA and its significance in transfusion. Blood. 1969 Nov; 34(5):573-81. PMID: 4187517.
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    144. Vyas G, Fudenberg HH. Isoimmune anti-IgA causing anaphylactoid transfusion reactions. N Engl J Med. 1969 May 8; 280(19):1073-4. PMID: 4180711.
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    145. Vyas G, Fudenberg HH. Evolutionary dissociation of gamma G2 and Gm (n) antigens. Vox Sang. 1969 Mar; 16(3):233-6. PMID: 4180803.
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    146. Vyas G, Fudenberg HH, Sassetti RJ, Petz LD. Experimental study of aldomet-induced positive antiglobulin reaction. I. Br J Haematol. 1969 Jan-Feb; 16(1):137-43. PMID: 5795204.
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    147. Vyas G, Perkins HA, Fudenberg HH. Anaphylactoid transfusion reactions associated with anti-IgA. Lancet. 1968 Aug 10; 2(7563):312-5. PMID: 4173734.
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    148. Vyas G, Munver UL, Salgaonkar DS, Purandare NM. Human cadaver blood for transfusion. Transfusion. 1968 Jul-Aug; 8(4):250-3. PMID: 4970379.
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    149. Fudenberg HH, Gold ER, Vyas G, Mackenzie MR. Human antibodies to human IgA globulins. Immunochemistry. 1968 Mar; 5(2):203-6. PMID: 4103908.
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    150. Vyas G, Fudenberg HH, Pretty HM, Gold ER. A new rapid method for genetic typing of human immunoglobulins. J Immunol. 1968 Feb; 100(2):274-9. PMID: 4170633.
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    151. Vyas G, Fudenberg HH. Use of B. subtilis neutral proteinase in blood group serology. Vox Sang. 1968; 15(4):300-3. PMID: 4971759.
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    152. Sathe MS, Vyas G, Bhatia HM, Purandare NM. Hemagglutinating substances in plant seeds. J Postgrad Med. 1967 Jan; 13(1):29-36. PMID: 6035742.
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    153. VYAS GN, SATHE MS, PURANDARE NM, SATOSKAR RS. RED CELL, PLASMA AND BLOOD VOLUME MEASURED BY RADIOCHROMIUM LABELLED CELLS AND HAEMATOCRIT IN INDIANS BELONGING TO LOW AND HIGH SOCIO-ECONOMIC GROUPS. Indian J Med Res. 1965 Feb; 53:122-39. PMID: 14276069.
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    154. VYAS GN, PANDIT HM, PURANDARE NM. Suppression of gene A in two cases of anti-H (Bombay bloods) in a family from South Canara. J Assoc Physicians India. 1962 Dec; 10:745-8. PMID: 13998077.
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    155. VYAS GN, BHATIA HM, SUKUMARAN PK, BALKRISHANAN V, SANGHVI LD. Study of blood groups, abnormal hemoglobins and other genetical characters in some tribes of Gujarat. Am J Phys Anthropol. 1962 Sep; 20:255-65. PMID: 13998076.
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    156. HAKIM SA, VYAS GN, SANGHVI LD, BHATIA HM. Eleven cases of "Bombay" phenotype in six families: suppression of ABO antigen demonstrated in two families. Transfusion. 1961 Jul-Aug; 1:218-22. PMID: 13710639.
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    157. VYAS GN, BHATIA HM, SANGHVI LD. Three cases of weak B in an Indian family. Vox Sang. 1960 Sep; 5:509-16. PMID: 13782300.
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    158. VYAS GN, BHATIA HM, BANKER DD, PURANDARE NM. Study of blood groups and other genetical characters in six Gujarati endogamous groups in Western India. Ann Hum Genet. 1958 May; 22(3):185-99. PMID: 13534204.
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    159. VYAS GN, SHAH NM. Chalkones from quinacetophenone monomethyl ether. Curr Sci. 1950 Oct; 19(10):318-9. PMID: 14792992.
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