Cheryl Stoddart, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-8149
EmailCheryl.Stoddart@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    Lebanon Valley College, Annville, PennsylvaniaBS05/1979Biology
    Cornell University, Ithaca, New YorkMS08/1983Virology
    Cornell University, Ithaca, New YorkPhD05/1989Virology
    Stanford University, Stanford, CaliforniaPostdoctoral06/1992Host-Parasite Interaction
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    My research has focused on the use of the SCID-hu Thy/Liv mouse model for preclinical evaluation of antiviral compounds and immunomodulating agents. The Thy/Liv model is constructed by implantation of organs supportive of human multilineage hematopoiesis and T-cell development (e.g., fetal liver and thymus) into the immunodeficient C.B-17 scid/scid mouse. Since 2000, I have been the Principal Investigator for a sole-sourced contract from NIH/NIAID, Tissue-Based Small Animal Model for HIV Drug Discovery funded to carry out these drug evaluations. The model has also been shown to be receptive to the surgical implantation of a number of other hematopoietic and nonhematopoietic human organ systems, including lymph node, small and large intestine, lung, skin, pituitary, ovary, and placenta. Mice with such implanted organs represent potential models that could be used to discover and evaluate stem cell populations normally resident within each of these organs.

    Collapse Research 
    Collapse Research Activities and Funding
    Single-chain antibodies to block HIV transcription and prevent reactivation from latently infected resting CD4+ T cells
    NIH R21AI156897Dec 1, 2020 - Nov 30, 2022
    Role: Principal Investigator
    Inhibition of heat shock protein 90 for sustained remission of HIV from persistent tissue reservoirs
    NIH R56AI147895Jul 10, 2020 - Jun 30, 2021
    Role: Principal Investigator
    IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"
    NIH 272201400002C-0-0-1Dec 6, 2013 - Dec 5, 2014
    Role: Principal Investigator
    Heat shock protein 90 and HIV persistence
    NIH R21AI108398May 17, 2013 - Apr 30, 2016
    Role: Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH N01AI70002-5-0-1Dec 6, 2006 - Dec 5, 2013
    Role: Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH/NIAID N01AI70002Dec 6, 2006
    Role: Co-Principal Investigator
    TISSUE-BASED SMALL ANIMAL MODEL FOR HIV DRUG DISCOVERY
    NIH/NIAID N01AI005418Aug 1, 2000 - Jul 31, 2007
    Role: Principal Investigator
    DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
    NIH N01AI000000Dec 31, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetically edited CD34+ cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells. Proc Natl Acad Sci U S A. 2021 May 18; 118(20). Morvan MG, Teque F, Ye L, Moreno ME, Wang J, VandenBerg S, Stoddart CA, Kan YW, Levy JA. PMID: 33975958.
      View in: PubMed   Mentions:    Fields:    
    2. Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection. Cell Rep. 2020 04 14; 31(2):107494. Cham LB, Torrez Dulgeroff LB, Tal MC, Adomati T, Li F, Bhat H, Huang A, Lang PA, Moreno ME, Rivera JM, Galkina SA, Kosikova G, Stoddart CA, McCune JM, Myers LM, Weissman IL, Lang KS, Hasenkrug KJ. PMID: 32294445.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    3. Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice. Viruses. 2019 03 13; 11(3). Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA. PMID: 30871222.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 02; 14(2):e1006856. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. PMID: 29470552.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    5. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 06; 66(6):427-446. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. PMID: 29462571.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Eradication of HIV from Tissue Reservoirs: Challenges for the Cure. AIDS Res Hum Retroviruses. 2018 01; 34(1):3-8. Rose R, Nolan DJ, Maidji E, Stoddart CA, Singer EJ, Lamers SL, McGrath MS. PMID: 28691499.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. PLoS Pathog. 2017 02; 13(2):e1006202. Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA. PMID: 28241080.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    8. HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer. J Virol. 2016 10 15; 90(20):8984-93. Rose R, Lamers SL, Nolan DJ, Maidji E, Faria NR, Pybus OG, Dollar JJ, Maruniak SA, McAvoy AC, Salemi M, Stoddart CA, Singer EJ, McGrath MS. PMID: 27466425.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    9. HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. J Virol. 2016 10 15; 90(20):8968-83. Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart CA, McGrath MS, Singer EJ. PMID: 27466426.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    10. Inhibition of Heat Shock Protein 90 Prevents HIV Rebound. J Biol Chem. 2016 May 06; 291(19):10332-46. Joshi P, Maidji E, Stoddart CA. PMID: 26957545.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment. Stem Cell Reports. 2016 Jan 12; 6(1):137-49. Ghosn EE, Waters J, Phillips M, Yamamoto R, Long BR, Yang Y, Gerstein R, Stoddart CA, Nakauchi H, Herzenberg LA. PMID: 26724903.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    12. The meningeal lymphatic system: a route for HIV brain migration? J Neurovirol. 2016 06; 22(3):275-81. Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS. PMID: 26572785.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    13. Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque. Antimicrob Agents Chemother. 2015 Jul; 59(7):4190-8. Stoddart CA, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA. PMID: 25941222.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice. Virology. 2014 Aug; 462-463:115-25. Stoddart CA, Galkina SA, Joshi P, Kosikova G, Long BR, Maidji E, Moreno ME, Rivera JM, Sanford UR, Sloan B, Cieplak W, Wrin T, Chan-Hui PY. PMID: 24971704.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology. 2013 Feb 05; 436(1):162-72. Joshi P, Sloan B, Torbett BE, Stoddart CA. PMID: 23200770.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection. J Virol. 2012 Dec; 86(23):12795-805. Maidji E, Kosikova G, Joshi P, Stoddart CA. PMID: 22973041.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice. Cytometry A. 2012 Aug; 81(8):646-8. Long BR, Stoddart CA. PMID: 22653780.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2012 Apr; 56(4):2162-5. Stoddart CA, Nault G, Galkina SA, Bousquet-Gagnon N, Bridon D, Quraishi O. PMID: 22252805.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice. J Virol. 2012 Mar; 86(6):3327-36. Long BR, Stoddart CA. PMID: 22238321.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    20. Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. Biologicals. 2012 Jan; 40(1):15-20. Vyas GN, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y. PMID: 22192456.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Potential role of heat shock protein 90 (Hsp90) in HIV uncoating. Retrovirology. 2011 Dec 1; 8(Suppl 2):p80. Pheroze Joshi, Cheryl A Stoddart. .
      View in: Publisher Site   Mentions:
    22. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8. Baum PD, Sullam PM, Stoddart CA, McCune JM. PMID: 21941165.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    23. Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R?(-/-) (NSG) BLT mice. Virology. 2011 Aug 15; 417(1):154-60. Stoddart CA, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, Sloan B, Joshi P, Long BR. PMID: 21684569.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    24. Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1. J Biol Chem. 2011 Jul 15; 286(28):24581-92. Joshi P, Stoddart CA. PMID: 21602280.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood. 2011 Feb 17; 117(7):2189-99. Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM. PMID: 21200021.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    26. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science. 2010 Dec 17; 330(6011):1695-9. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM. PMID: 21164017.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    27. How the immune system ‘Grows up’: evidence supporting the existence of a layered immune system. Journal of Reproductive Immunology. 2010 Aug 1; 86(1):21. J.E. Mold, S. Venkatasubrahmanyam, T.D. Burt, J. Rivera, S.A. Galkina, K. Weinberg, A. Butte, C.A. Stoddart, J.M. McCune. .
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    28. An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life. Antimicrobial Agents and Chemotherapy. 2010 Aug 1; 54(8):3535-3535. Dong Xie, Cheng Yao, Li Wang, Cheryl A. Stoddart, Roger G. Ptak, Wenjie Min, Jiahong Xu, Jiahai Xiao, Mingxian Huang, Bo Chen, Bin Liu, Xiaolin Li, He Jiang. .
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    29. IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog. 2010 Feb 19; 6(2):e1000766. Stoddart CA, Keir ME, McCune JM. PMID: 20174557.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    30. Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. J Biol Chem. 2008 Dec 05; 283(49):34045-52. Stoddart CA, Nault G, Galkina SA, Thibaudeau K, Bakis P, Bousquet-Gagnon N, Robitaille M, Bellomo M, Paradis V, Liscourt P, Lobach A, Rivard ME, Ptak RG, Mankowski MK, Bridon D, Quraishi O. PMID: 18809675.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS One. 2007 Nov 28; 2(11):e1251. Stoddart CA, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE. PMID: 18043758.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    32. Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PLoS One. 2007 Aug 01; 2(7):e655. Stoddart CA, Bales CA, Bare JC, Chkhenkeli G, Galkina SA, Kinkade AN, Moreno ME, Rivera JM, Ronquillo RE, Sloan B, Black PL. PMID: 17668043.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    33. Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum. J Nat Prod. 2007 Feb; 70(2):312-5. Chen JL, Kernan MR, Jolad SD, Stoddart CA, Bogan M, Cooper R. PMID: 17315968.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    34. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Journal of Clinical Investigation. 2006 Oct 2; 116(10):2643-2652. K. Red-Horse, J. Rivera, A. Schanz, Y. Zhou, V. Winn, M. Kapidzic, E. Maltepe, K. Okazaki, R. Kochman, K. C. Vo, L. Giudice, A. Erlebacher, J. M. McCune, C. A. Stoddart, S. J. Fisher. .
      View in: Publisher Site   Mentions:
    35. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. PMID: 16998586.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    36. Models of HIV-1 disease: A review of current status. Drug Discovery Today Disease Models. 2006 Mar 1; 3(1):113-119. Cheryl A. Stoddart, Richard A. Reyes. .
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    37. Suppression of lymphocyte egress in simian immunodeficiency virus-infected rhesus macaques. The FASEB Journal. 2006 Mar 1; 20(5):lb116-lb116. Richard A Reyes, Cheryl Stoddart. .
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    38. Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells. J Biol Chem. 2005 Dec 02; 280(48):40293-300. Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart CA, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA. PMID: 16199531.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    39. Coxsackievirus B4 infection of human fetal thymus cells. J Virol. 2004 Sep; 78(18):9854-61. Brilot F, Geenen V, Hober D, Stoddart CA. PMID: 15331720.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    40. Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7058-63. Sandberg JK, Stoddart CA, Brilot F, Jordan KA, Nixon DF. PMID: 15118099.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    41. Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J Immunol. 2003 Jul 15; 171(2):645-54. Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM. PMID: 12847229.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol. 2003 Feb; 77(3):2124-33. Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC. PMID: 12525647.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    43. Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. J Immunol. 2002 Sep 01; 169(5):2788-96. Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon DF, Stoddart CA, McCune JM. PMID: 12193754.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    44. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J Immunol. 2002 Jan 01; 168(1):325-31. Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM. PMID: 11751977.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Chapter 129 The SCID-hu Thy/Liv Mouse An Animal Model for HIV-1 Infection. Handbook of Animal Models of Infection. 1999 Jan 1; (Nature3631993):1069-1076. C.A. Stoddart. .
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