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Cheryl Stoddart, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8149
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    My research has focused on the use of the SCID-hu Thy/Liv mouse model for preclinical evaluation of antiviral compounds and immunomodulating agents. The Thy/Liv model is constructed by implantation of organs supportive of human multilineage hematopoiesis and T-cell development (e.g., fetal liver and thymus) into the immunodeficient C.B-17 scid/scid mouse. Since 2000, I have been the Principal Investigator for a sole-sourced contract from NIH/NIAID, Tissue-Based Small Animal Model for HIV Drug Discovery funded to carry out these drug evaluations. The model has also been shown to be receptive to the surgical implantation of a number of other hematopoietic and nonhematopoietic human organ systems, including lymph node, small and large intestine, lung, skin, pituitary, ovary, and placenta. Mice with such implanted organs represent potential models that could be used to discover and evaluate stem cell populations normally resident within each of these organs.


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    Collapse Research Activities and Funding
    IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"
    NIH 272201400002C-0-0-1Dec 6, 2013 - Dec 5, 2014
    Role: Principal Investigator
    Heat shock protein 90 and HIV persistence
    NIH/NIAID R21AI108398May 17, 2013 - Apr 30, 2015
    Role: Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH/NIAID N01AI70002Dec 6, 2006 - Dec 5, 2013
    Role: Co-Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH/NIAID N01AI70002-5-0-1Dec 6, 2006 - Dec 5, 2013
    Role: Principal Investigator
    DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
    NIH/NIAID N01AI000000Jul 1, 2003 - Jan 5, 2024
    Role: Co-Principal Investigator
    TISSUE-BASED SMALL ANIMAL MODEL FOR HIV DRUG DISCOVERY
    NIH/NIAID N01AI005418Aug 1, 2000 - Jul 31, 2007
    Role: Principal Investigator

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    Collapse Global Health

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart C. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. PLoS Pathog. 2017 Feb; 13(2):e1006202. PMID: 28241080.
      View in: PubMed
    2. Rose R, Lamers SL, Nolan DJ, Maidji E, Faria NR, Pybus OG, Dollar JJ, Maruniak SA, McAvoy AC, Salemi M, Stoddart C, Singer EJ, McGrath MS. HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer. J Virol. 2016 Oct 15; 90(20):8984-93. PMID: 27466425.
      View in: PubMed
    3. Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart C, McGrath MS, Singer EJ. HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. J Virol. 2016 Oct 15; 90(20):8968-83. PMID: 27466426.
      View in: PubMed
    4. Joshi P, Maidji E, Stoddart C. Inhibition of Heat Shock Protein 90 Prevents HIV Rebound. J Biol Chem. 2016 May 6; 291(19):10332-46. PMID: 26957545.
      View in: PubMed
    5. Ghosn EE, Waters J, Phillips M, Yamamoto R, Long BR, Yang Y, Gerstein R, Stoddart C, Nakauchi H, Herzenberg LA. Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment. Stem Cell Reports. 2016 Jan 12; 6(1):137-49. PMID: 26724903.
      View in: PubMed
    6. Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart C, McGrath MS. The meningeal lymphatic system: a route for HIV brain migration? J Neurovirol. 2016 Jun; 22(3):275-81. PMID: 26572785.
      View in: PubMed
    7. Stoddart C, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA. Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque. Antimicrob Agents Chemother. 2015 Jul; 59(7):4190-8. PMID: 25941222; PMCID: PMC4468726.
    8. Laing ST, Griffey SM, Moreno ME, Stoddart C. CD8-positive lymphocytes in graft-versus-host disease of humanized NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ mice. J Comp Pathol. 2015 Feb-Apr; 152(2-3):238-42. PMID: 25670669.
      View in: PubMed
    9. Stoddart C, Galkina SA, Joshi P, Kosikova G, Long BR, Maidji E, Moreno ME, Rivera JM, Sanford UR, Sloan B, Cieplak W, Wrin T, Chan-Hui PY. Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice. Virology. 2014 Aug; 462-463:115-25. PMID: 24971704; PMCID: PMC4125441.
    10. Joshi P, Sloan B, Torbett BE, Stoddart C. Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology. 2013 Feb 5; 436(1):162-72. PMID: 23200770; PMCID: PMC3563299.
    11. Maidji E, Kosikova G, Joshi P, Stoddart C. Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection. J Virol. 2012 Dec; 86(23):12795-805. PMID: 22973041; PMCID: PMC3497636.
    12. Long BR, Stoddart C. OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice. Cytometry A. 2012 Aug; 81(8):646-8. PMID: 22653780.
      View in: PubMed
    13. Stoddart C, Nault G, Galkina SA, Bousquet-Gagnon N, Bridon D, Quraishi O. Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2012 Apr; 56(4):2162-5. PMID: 22252805; PMCID: PMC3318323.
    14. Long BR, Stoddart C. Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice. J Virol. 2012 Mar; 86(6):3327-36. PMID: 22238321; PMCID: PMC3302309.
    15. Vyas GN, Stoddart C, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y. Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. Biologicals. 2012 Jan; 40(1):15-20. PMID: 22192456.
      View in: PubMed
    16. Baum PD, Sullam PM, Stoddart C, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8. PMID: 21941165; PMCID: PMC3272328.
    17. Stoddart C, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, Sloan B, Joshi P, Long BR. Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R?(-/-) (NSG) BLT mice. Virology. 2011 Aug 15; 417(1):154-60. PMID: 21684569; PMCID: PMC3152643.
    18. Joshi P, Stoddart C. Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1. J Biol Chem. 2011 Jul 15; 286(28):24581-92. PMID: 21602280; PMCID: PMC3137033.
    19. Favre D, Stoddart C, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM. HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood. 2011 Feb 17; 117(7):2189-99. PMID: 21200021; PMCID: PMC3062328.
    20. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaƫlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart C, McCune JM. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science. 2010 Dec 17; 330(6011):1695-9. PMID: 21164017; PMCID: PMC3276679.
    21. Stoddart C, Keir ME, McCune JM. IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog. 2010 Feb; 6(2):e1000766. PMID: 20174557; PMCID: PMC2824759.
    22. Stoddart C, Nault G, Galkina SA, Thibaudeau K, Bakis P, Bousquet-Gagnon N, Robitaille M, Bellomo M, Paradis V, Liscourt P, Lobach A, Rivard ME, Ptak RG, Mankowski MK, Bridon D, Quraishi O. Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. J Biol Chem. 2008 Dec 5; 283(49):34045-52. PMID: 18809675; PMCID: PMC2590714.
    23. Stoddart C, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE. Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS One. 2007; 2(11):e1251. PMID: 18043758; PMCID: PMC2080775.
    24. Stoddart C, Bales CA, Bare JC, Chkhenkeli G, Galkina SA, Kinkade AN, Moreno ME, Rivera JM, Ronquillo RE, Sloan B, Black PL. Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PLoS One. 2007; 2(7):e655. PMID: 17668043; PMCID: PMC1925140.
    25. Chen JL, Kernan MR, Jolad SD, Stoddart C, Bogan M, Cooper R. Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum. J Nat Prod. 2007 Feb; 70(2):312-5. PMID: 17315968.
      View in: PubMed
    26. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart C, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. PMID: 16998586; PMCID: PMC1570373.
    27. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart C, Fisher SJ. Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Lymphat Res Biol. 2006; 4(4):229-42. PMID: 17394406.
      View in: PubMed
    28. Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart C, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA. Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells. J Biol Chem. 2005 Dec 2; 280(48):40293-300. PMID: 16199531.
      View in: PubMed
    29. Brilot F, Geenen V, Hober D, Stoddart C. Coxsackievirus B4 infection of human fetal thymus cells. J Virol. 2004 Sep; 78(18):9854-61. PMID: 15331720; PMCID: PMC514990.
    30. Sandberg JK, Stoddart C, Brilot F, Jordan KA, Nixon DF. Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A. 2004 May 4; 101(18):7058-63. PMID: 15118099; PMCID: PMC406465.
    31. Napolitano LA, Stoddart C, Hanley MB, Wieder E, McCune JM. Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J Immunol. 2003 Jul 15; 171(2):645-54. PMID: 12847229.
      View in: PubMed
    32. Stoddart C, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol. 2003 Feb; 77(3):2124-33. PMID: 12525647; PMCID: PMC140869.
    33. Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon DF, Stoddart C, McCune JM. Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. J Immunol. 2002 Sep 1; 169(5):2788-96. PMID: 12193754.
      View in: PubMed
    34. Keir ME, Stoddart C, Linquist-Stepps V, Moreno ME, McCune JM. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J Immunol. 2002 Jan 1; 168(1):325-31. PMID: 11751977.
      View in: PubMed
    35. Strizki JM, Xu S, Wagner NE, Wojcik L, Liu J, Hou Y, Endres M, Palani A, Shapiro S, Clader JW, Greenlee WJ, Tagat JR, McCombie S, Cox K, Fawzi AB, Chou CC, Pugliese-Sivo C, Davies L, Moreno ME, Ho DD, Trkola A, Stoddart C, Moore JP, Reyes GR, Baroudy BM. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12718-23. PMID: 11606733; PMCID: PMC60120.
    36. Stoddart C, Liegler TJ, Mammano F, Linquist-Stepps VD, Hayden MS, Deeks SG, Grant RM, Clavel F, McCune JM. Impaired replication of protease inhibitor-resistant HIV-1 in human thymus. Nat Med. 2001 Jun; 7(6):712-8. PMID: 11385509.
      View in: PubMed
    37. Gobbi A, Stoddart C, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P. Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1. J Virol. 2000 Sep; 74(18):8726-31. PMID: 10954574; PMCID: PMC116384.
    38. Stoddart C, Moreno ME, Linquist-Stepps VD, Bare C, Bogan MR, Gobbi A, Buckheit RW, Bedard J, Rando RF, McCune JM. Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2000 Mar; 44(3):783-6. PMID: 10681360; PMCID: PMC89768.
    39. Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med. 1999 Dec 20; 190(12):1857-68. PMID: 10601360; PMCID: PMC2195708.
    40. Berkowitz RD, van't Wout AB, Kootstra NA, Moreno ME, Linquist-Stepps VD, Bare C, Stoddart C, Schuitemaker H, McCune JM. R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus. J Virol. 1999 Sep; 73(9):7817-22. PMID: 10438873; PMCID: PMC104310.
    41. Gobbi A, Stoddart C, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM. Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. J Exp Med. 1999 Jun 21; 189(12):1953-60. PMID: 10377191; PMCID: PMC2192958.
    42. Berkowitz RD, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno ME, Gibson L, Wieder ED, Kosek J, Stoddart C, McCune JM. CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo. J Virol. 1998 Dec; 72(12):10108-17. PMID: 9811751; PMCID: PMC110545.
    43. Chen JL, Blanc P, Stoddart C, Bogan M, Rozhon EJ, Parkinson N, Ye Z, Cooper R, Balick M, Nanakorn W, Kernan MR. New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus. J Nat Prod. 1998 Oct; 61(10):1295-7. PMID: 9784173.
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    44. Stoddart C, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM. Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320. Antimicrob Agents Chemother. 1998 Aug; 42(8):2113-5. PMID: 9687417; PMCID: PMC105876.
    45. Kernan MR, Amarquaye A, Chen JL, Chan J, Sesin DF, Parkinson N, Ye Z, Barrett M, Bales C, Stoddart C, Sloan B, Blanc P, Limbach C, Mrisho S, Rozhon EJ. Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea. J Nat Prod. 1998 May; 61(5):564-70. PMID: 9599250.
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    46. Linquist V, Stoddart C, McCune JM. UV irradiation of polystyrene pipets releases PCR inhibitors. Biotechniques. 1998 Jan; 24(1):50-2. PMID: 9454951.
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    47. Kernan MR, Sendl A, Chen JL, Jolad SD, Blanc P, Murphy JT, Stoddart C, Nanakorn W, Balick MJ, Rozhon EJ. Two new lignans with activity against influenza virus from the medicinal plant Rhinacanthus nasutus. J Nat Prod. 1997 Jun; 60(6):635-7. PMID: 9214738.
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    48. Sendl A, Chen JL, Jolad SD, Stoddart C, Rozhon E, Kernan M, Nanakorn W, Balick M. Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus. J Nat Prod. 1996 Aug; 59(8):808-11. PMID: 8792629.
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    49. Cardin RD, Abenes GB, Stoddart C, Mocarski ES. Murine cytomegalovirus IE2, an activator of gene expression, is dispensable for growth and latency in mice. Virology. 1995 May 10; 209(1):236-41. PMID: 7747475.
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    50. Stoddart C, Cardin RD, Boname JM, Manning WC, Abenes GB, Mocarski ES. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J Virol. 1994 Oct; 68(10):6243-53. PMID: 8083964; PMCID: PMC237044.
    51. Ubillas R, Jolad SD, Bruening RC, Kernan MR, King SR, Sesin DF, Barrett M, Stoddart C, Flaster T, Kuo J, Ayala F, Meza E, CastaƱel M, McMeekin D, Rozhon E, Tempesta MS, Barnard D, Huffman J, Smee D, Sidwell R, Soike K, Brazier A, Safrin S, Orlando R, Kenny PT, Berova N, Nakanishi K. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine. 1994 Sep; 1(2):77-106. PMID: 23195881.
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    52. Manning WC, Stoddart C, Lagenaur LA, Abenes GB, Mocarski ES. Cytomegalovirus determinant of replication in salivary glands. J Virol. 1992 Jun; 66(6):3794-802. PMID: 1316482; PMCID: PMC241165.
    53. Stoddart C, Scott FW. Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence. J Virol. 1989 Jan; 63(1):436-40. PMID: 2521188; PMCID: PMC247703.
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