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Cheryl Stoddart, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8149
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    Collapse Overview
    My research has focused on the use of the SCID-hu Thy/Liv mouse model for preclinical evaluation of antiviral compounds and immunomodulating agents. The Thy/Liv model is constructed by implantation of organs supportive of human multilineage hematopoiesis and T-cell development (e.g., fetal liver and thymus) into the immunodeficient C.B-17 scid/scid mouse. Since 2000, I have been the Principal Investigator for a sole-sourced contract from NIH/NIAID, Tissue-Based Small Animal Model for HIV Drug Discovery funded to carry out these drug evaluations. The model has also been shown to be receptive to the surgical implantation of a number of other hematopoietic and nonhematopoietic human organ systems, including lymph node, small and large intestine, lung, skin, pituitary, ovary, and placenta. Mice with such implanted organs represent potential models that could be used to discover and evaluate stem cell populations normally resident within each of these organs.


    Collapse Research 
    Collapse Research Activities and Funding
    IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"
    NIH 272201400002C-0-0-1Dec 6, 2013 - Dec 5, 2014
    Role: Principal Investigator
    Heat shock protein 90 and HIV persistence
    NIH/NIAID R21AI108398May 17, 2013 - Apr 30, 2015
    Role: Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH/NIAID N01AI70002Dec 6, 2006 - Dec 5, 2013
    Role: Co-Principal Investigator
    Tissue Based Small Animal Model for HIV Drug Discovery
    NIH/NIAID N01AI70002-5-0-1Dec 6, 2006 - Dec 5, 2013
    Role: Principal Investigator
    DMID CLINICAL RESEARCH OPERATIONS AND MANAGEMENT SUPPORT
    NIH/NIAID N01AI000000Jul 1, 2003 - Jul 13, 2024
    Role: Co-Principal Investigator
    TISSUE-BASED SMALL ANIMAL MODEL FOR HIV DRUG DISCOVERY
    NIH/NIAID N01AI005418Aug 1, 2000 - Jul 31, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 Feb; 14(2):e1006856. PMID: 29470552.
      View in: PubMed
    2. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 Feb 01; 22155418756848. PMID: 29462571.
      View in: PubMed
    3. Rose R, Nolan DJ, Maidji E, Stoddart CA, Singer EJ, Lamers SL, McGrath MS. Eradication of HIV from Tissue Reservoirs: Challenges for the Cure. AIDS Res Hum Retroviruses. 2018 Jan; 34(1):3-8. PMID: 28691499.
      View in: PubMed
    4. Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. PLoS Pathog. 2017 Feb; 13(2):e1006202. PMID: 28241080.
      View in: PubMed
    5. Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart CA, McGrath MS, Singer EJ. HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. J Virol. 2016 10 15; 90(20):8968-83. PMID: 27466426.
      View in: PubMed
    6. Rose R, Lamers SL, Nolan DJ, Maidji E, Faria NR, Pybus OG, Dollar JJ, Maruniak SA, McAvoy AC, Salemi M, Stoddart CA, Singer EJ, McGrath MS. HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer. J Virol. 2016 10 15; 90(20):8984-93. PMID: 27466425.
      View in: PubMed
    7. Joshi P, Maidji E, Stoddart CA. Inhibition of Heat Shock Protein 90 Prevents HIV Rebound. J Biol Chem. 2016 May 06; 291(19):10332-46. PMID: 26957545; PMCID: PMC4858980.
    8. Ghosn EE, Waters J, Phillips M, Yamamoto R, Long BR, Yang Y, Gerstein R, Stoddart CA, Nakauchi H, Herzenberg LA. Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment. Stem Cell Reports. 2016 Jan 12; 6(1):137-49. PMID: 26724903; PMCID: PMC4720028.
    9. Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS. The meningeal lymphatic system: a route for HIV brain migration? J Neurovirol. 2016 06; 22(3):275-81. PMID: 26572785.
      View in: PubMed
    10. Stoddart CA, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA. Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque. Antimicrob Agents Chemother. 2015 Jul; 59(7):4190-8. PMID: 25941222; PMCID: PMC4468726.
    11. Stoddart CA, Galkina SA, Joshi P, Kosikova G, Long BR, Maidji E, Moreno ME, Rivera JM, Sanford UR, Sloan B, Cieplak W, Wrin T, Chan-Hui PY. Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice. Virology. 2014 Aug; 462-463:115-25. PMID: 24971704.
      View in: PubMed
    12. Joshi P, Sloan B, Torbett BE, Stoddart CA. Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology. 2013 Feb 05; 436(1):162-72. PMID: 23200770.
      View in: PubMed
    13. Maidji E, Kosikova G, Joshi P, Stoddart CA. Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection. J Virol. 2012 Dec; 86(23):12795-805. PMID: 22973041; PMCID: PMC3497636.
    14. Long BR, Stoddart CA. OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice. Cytometry A. 2012 Aug; 81(8):646-8. PMID: 22653780.
      View in: PubMed
    15. Stoddart CA, Nault G, Galkina SA, Bousquet-Gagnon N, Bridon D, Quraishi O. Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2012 Apr; 56(4):2162-5. PMID: 22252805; PMCID: PMC3318323.
    16. Long BR, Stoddart CA. Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice. J Virol. 2012 Mar; 86(6):3327-36. PMID: 22238321; PMCID: PMC3302309.
    17. Vyas GN, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y. Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. Biologicals. 2012 Jan; 40(1):15-20. PMID: 22192456.
      View in: PubMed
    18. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8. PMID: 21941165; PMCID: PMC3272328.
    19. Stoddart CA, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, Sloan B, Joshi P, Long BR. Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R?(-/-) (NSG) BLT mice. Virology. 2011 Aug 15; 417(1):154-60. PMID: 21684569; PMCID: PMC3152643.
    20. Joshi P, Stoddart CA. Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1. J Biol Chem. 2011 Jul 15; 286(28):24581-92. PMID: 21602280; PMCID: PMC3137033.
    21. Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM. HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood. 2011 Feb 17; 117(7):2189-99. PMID: 21200021; PMCID: PMC3062328.
    22. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaƫlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science. 2010 Dec 17; 330(6011):1695-9. PMID: 21164017; PMCID: PMC3276679.
    23. Stoddart CA, Keir ME, McCune JM. IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog. 2010 Feb 19; 6(2):e1000766. PMID: 20174557; PMCID: PMC2824759.
    24. Stoddart CA, Nault G, Galkina SA, Thibaudeau K, Bakis P, Bousquet-Gagnon N, Robitaille M, Bellomo M, Paradis V, Liscourt P, Lobach A, Rivard ME, Ptak RG, Mankowski MK, Bridon D, Quraishi O. Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. J Biol Chem. 2008 Dec 05; 283(49):34045-52. PMID: 18809675; PMCID: PMC2590714.
    25. Stoddart CA, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE. Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS One. 2007 Nov 28; 2(11):e1251. PMID: 18043758; PMCID: PMC2080775.
    26. Stoddart CA, Bales CA, Bare JC, Chkhenkeli G, Galkina SA, Kinkade AN, Moreno ME, Rivera JM, Ronquillo RE, Sloan B, Black PL. Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PLoS One. 2007 Aug 01; 2(7):e655. PMID: 17668043; PMCID: PMC1925140.
    27. Chen JL, Kernan MR, Jolad SD, Stoddart CA, Bogan M, Cooper R. Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum. J Nat Prod. 2007 Feb; 70(2):312-5. PMID: 17315968.
      View in: PubMed
    28. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. PMID: 16998586; PMCID: PMC1570373.
    29. Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart CA, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA. Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells. J Biol Chem. 2005 Dec 02; 280(48):40293-300. PMID: 16199531.
      View in: PubMed
    30. Brilot F, Geenen V, Hober D, Stoddart CA. Coxsackievirus B4 infection of human fetal thymus cells. J Virol. 2004 Sep; 78(18):9854-61. PMID: 15331720; PMCID: PMC514990.
    31. Sandberg JK, Stoddart CA, Brilot F, Jordan KA, Nixon DF. Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7058-63. PMID: 15118099; PMCID: PMC406465.
    32. Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM. Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J Immunol. 2003 Jul 15; 171(2):645-54. PMID: 12847229.
      View in: PubMed
    33. Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol. 2003 Feb; 77(3):2124-33. PMID: 12525647; PMCID: PMC140869.
    34. Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon DF, Stoddart CA, McCune JM. Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. J Immunol. 2002 Sep 01; 169(5):2788-96. PMID: 12193754.
      View in: PubMed
    35. Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J Immunol. 2002 Jan 01; 168(1):325-31. PMID: 11751977.
      View in: PubMed
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