Hailyn Nielsen, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #1201E
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of Iowa, Iowa City, IowaBS05/2005Microbiology
    Washington University in St. Louis, School of Medicine, St. Louis, MOPhD05/2015Molecular Microbiology and Microbial Pathogenesis
    Washington University in St. Louis, School of Medicine, St. Louis, MOMD05/2015
    University of California - San Francisco, San Francisco, CAResidency06/2018Internal Medicine
    University of California - San Francisco, San Francisco, CAFellowship05/2022Rheumatology
    Collapse Awards and Honors
    American Heart Association Midwest Affiliate2010  - 2011Predoctoral Fellowship
    Rheumatology Research Foundation2022  - 2025Scientist Development Award

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist in the UCSF Division of Rheumatology. I keep a general rheumatology clinic at the Parnassus campus where I treat patients with autoimmune diseases. Additionally, I carry out post-doctoral research in the laboratory of Dr. Julie Zikherman also in the Division of Rheumatology. Broadly, my research involves using mouse models of autoimmunity to dissect molecular mechanisms of immune tolerance.

    Collapse Research 
    Collapse Research Activities and Funding
    Control of T cell tolerance by the NR4A family of nuclear receptors
    Rheumatology Research Foundation Scientist Development AwardJul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular basis for potent B cell responses to antigen displayed on particles of viral size. Nat Immunol. 2023 Oct; 24(10):1762-1777. Brooks JF, Riggs J, Mueller JL, Mathenge R, Wholey WY, Meyer AR, Yoda ST, Vykunta VS, Nielsen HV, Cheng W, Zikherman J. PMID: 37653247; PMCID: PMC10950062.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    2. NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance. Immunol Rev. 2022 05; 307(1):116-133. Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J. PMID: 35174510.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    3. NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. JCI Insight. 2021 09 08; 6(17). Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J. PMID: 34343134; PMCID: PMC8492309.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiol Spectr. 2016 Feb; 4(1). O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ. PMID: 26999391; PMCID: PMC4887100.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    5. Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence. Infect Immun. 2013 Dec; 81(12):4525-33. Korte-Berwanger M, Sakinc T, Kline K, Nielsen HV, Hultgren S, Gatermann SG. PMID: 24082071; PMCID: PMC3837983.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    6. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol. 2013 Oct; 195(19):4484-95. Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. PMID: 23913319; PMCID: PMC3807452.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    7. Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infect Immun. 2013 May; 81(5):1606-17. Watson ME, Nielsen HV, Hultgren SJ, Caparon MG. PMID: 23460515; PMCID: PMC3648019.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    8. The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. mBio. 2012; 3(4):e00177-12. Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. PMID: 22829678; PMCID: PMC3419518.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    9. A reference map of the membrane proteome of Enterococcus faecalis. Proteomics. 2011 Oct; 11(19):3935-41. Maddalo G, Chovanec P, Stenberg-Bruzell F, Nielsen HV, Jensen-Seaman MI, Ilag LL, Kline KA, Daley DO. PMID: 21800426; PMCID: PMC3517079.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    10. Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun. 2010 May; 78(5):1943-51. Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ. PMID: 20176795; PMCID: PMC2863549.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    11. G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cell Microbiol. 2008 Dec; 10(12):2568-78. Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ. PMID: 18754853; PMCID: PMC3036167.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
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